CN104666285B - The disposable quick-drying detergent for cleaning hand of sodium azulenesulfonate antiallergy - Google Patents
The disposable quick-drying detergent for cleaning hand of sodium azulenesulfonate antiallergy Download PDFInfo
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- CN104666285B CN104666285B CN201510050435.1A CN201510050435A CN104666285B CN 104666285 B CN104666285 B CN 104666285B CN 201510050435 A CN201510050435 A CN 201510050435A CN 104666285 B CN104666285 B CN 104666285B
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- hand
- skin
- antiallergy
- sodium azulenesulfonate
- sodium
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- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 title claims abstract description 18
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 14
- 238000001035 drying Methods 0.000 title claims abstract description 14
- 238000004140 cleaning Methods 0.000 title abstract description 5
- 239000003599 detergent Substances 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000004373 Pullulan Substances 0.000 claims description 7
- 229920001218 Pullulan Polymers 0.000 claims description 7
- 235000019423 pullulan Nutrition 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 6
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 5
- 235000019388 lanolin Nutrition 0.000 claims description 5
- 229920002643 polyglutamic acid Polymers 0.000 claims description 5
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 4
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 4
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 229960000458 allantoin Drugs 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 3
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 14
- 241000894006 Bacteria Species 0.000 abstract description 6
- 239000002904 solvent Substances 0.000 abstract description 6
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 5
- 244000052616 bacterial pathogen Species 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 241000588724 Escherichia coli Species 0.000 abstract description 3
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 3
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 238000005406 washing Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000037311 normal skin Effects 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 241000712461 unidentified influenza virus Species 0.000 abstract description 2
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 8
- 229920002125 Sokalan® Polymers 0.000 description 8
- 229960001631 carbomer Drugs 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229960003260 chlorhexidine Drugs 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- UMGXUWVIJIQANV-UHFFFAOYSA-M didecyl(dimethyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC UMGXUWVIJIQANV-UHFFFAOYSA-M 0.000 description 4
- -1 hydroxyl diphenyl ether Chemical compound 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000004006 olive oil Substances 0.000 description 4
- 235000008390 olive oil Nutrition 0.000 description 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 208000035473 Communicable disease Diseases 0.000 description 3
- 206010011409 Cross infection Diseases 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Natural products C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 2
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 2
- 241000709661 Enterovirus Species 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 241000220317 Rosa Species 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229940069521 aloe extract Drugs 0.000 description 2
- 229960002233 benzalkonium bromide Drugs 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 229940049638 carbomer homopolymer type c Drugs 0.000 description 2
- 229940043234 carbomer-940 Drugs 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 2
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 229960005150 glycerol Drugs 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 208000006400 Arbovirus Encephalitis Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010052369 Encephalitis lethargica Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010061182 Genitourinary tract infection Diseases 0.000 description 1
- 206010061192 Haemorrhagic fever Diseases 0.000 description 1
- 241000711549 Hepacivirus C Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000002979 Influenza in Birds Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241000702670 Rotavirus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- ITFDXZLLAMYMBM-UHFFFAOYSA-N [Br-].[NH4+].[NH4+].C(CCCCCCCCCCC)C(=CC)C.[Br-] Chemical compound [Br-].[NH4+].[NH4+].C(CCCCCCCCCCC)C(=CC)C.[Br-] ITFDXZLLAMYMBM-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000012876 acute enteritis Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 201000009361 ascariasis Diseases 0.000 description 1
- 206010064097 avian influenza Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 206010014881 enterobiasis Diseases 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 210000001145 finger joint Anatomy 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000009340 pathogen transmission Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000004441 taeniasis Diseases 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 201000002498 viral encephalitis Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Detergent Compositions (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
A kind of disposable quick-drying detergent for cleaning hand of sodium azulenesulfonate antiallergy, including：Antiseptic 0.1%~4.5%；Skin conditioner 0.1%~20%；Sodium azulenesulfonate 0.1%~3%；Auxiliary material 0.5%~15%；Solvent is surplus.The disposable quick-drying detergent for cleaning hand of sodium azulenesulfonate antiallergy of the present invention, gloss, Non-water washing as glittering and translucent, royal purple crystal, integrates antibacterial, environmental protection, skin care.The various viral germs that the present invention can be quickly and effectively killed in 1 minute between palm and webs are (avian influenza virus, B-mode, HCV, pathogenic entero becteria, Escherichia coli, staphylococcus aureus, saccharomytes etc.), both hands do not have bacteria breed in 4 hours after sterilization.More than 99% antibacterial effect, 1 2ml, hand will rapid-curing cutback in 1 minute 30 seconds.PH value of the present invention is nontoxic to normal skin non-stimulated close to acid-base scale of skin, safe and efficient.With beneficial to environmental protection, it is convenient for carrying, whenever and wherever possible all workable feature.
Description
Technical Field
The invention relates to a hand cleaner. In particular to an antiallergic no-clean quick-drying hand cleaner containing sodium azulene sulfonate.
Background
The normal bacteria on the surface of the hand can not cause infection and illness under normal conditions, but the hand has a large range of motion and is often the part with the most bacteria, so the hand is very easy to be polluted by pathogenic microorganisms, and the hand is particularly suitable for medical institutions, banks, entertainment places, schools and offices, and public places such as homes, business trips, travels and the like. The diseases spread by hand are many and have wide range. The hand is an important medium for pathogen transmission in the infectious disease process, and the hand is also the most important transmission way in hospital infection, and domestic statistics shows that many infectious diseases are usually caused by hand transmission directly or indirectly, and are also usually transmitted by hands for people with low body resistance and the infection of normal flora of human body. Therefore, the daily hand disinfection is not a trivial matter, and is related to the health of people, the hand disinfection can protect people from infection, the hand disinfection of medical care personnel can prevent bacteria from invading the body of patients to reduce the occurrence of nosocomial infection, and the hand hygiene plays an important role in cross infection.
People often think of 'disease entering from the mouth' in life, but the disease is the chief culprit in some cases, and the disease serves as a transportation tool between germs and the mouth. The size is just the waste of the human body, containing various bacterial and parasitic eggs. Parasitic ova are most likely to enter the human body through the mouth by hand transmission, resulting in occurrence of ascariasis, enterobiasis, taeniasis, and the like. The occurrence and prevalence of some diseases such as bacillary dysentery, acute enteritis, acute gastritis, etc. are also closely related to the insanitation of the hands after defecation. Many infections are associated with hand hygiene. The enterovirus (EV71) is mainly transmitted through feces-mouth and/respiratory tract droplets, SARS is transmitted through respiratory tract and close contact, and human avian influenza is mainly transmitted through the ways of contacting diseased poultry and articles polluted by virus, including feces, feathers, respiratory tract secretion, viscera of poultry, eggs stained with poultry feces, blood and the like. (ii) a Other infectious diseases associated with hand hygiene are: typhoid, dysentery, cholera, hepatitis A, hemorrhagic fever, rotavirus diarrhea, epidemic encephalitis, various parasitic diseases, skin diseases, genitourinary tract infection, etc. Therefore, hand hygiene and disinfection is the simplest, most effective, most convenient, and most economical method of controlling infection.
Disclosure of Invention
The invention aims to solve the technical problem of providing the antiallergic no-clean quick-drying hand cleaner which is suitable for the medical staff or the outing business staff and the travelers to disinfect the hands when the hands are inconvenient to use water.
The technical scheme adopted by the invention is as follows: an antiallergic no-clean quick-drying hand cleaner containing sodium azulene sulfonate comprises: 0.1 to 4.5 percent of antibacterial agent; 0.1 to 20 percent of skin care agent; 0.1 to 3 percent of sodium azulene sulfonate; 0.5 to 15 percent of auxiliary material; the solvent is the rest.
The antibacterial agent is trichloro hydroxyl diphenyl ether or chlorhexidine or quaternary ammonium salt.
The chlorhexidine is chlorhexidine gluconate or chlorhexidine acetate.
The quaternary ammonium salt is benzalkonium chloride or benzalkonium bromide or didecyl dimethyl ammonium chloride or diethyienediammonium bromide or n-alkyl dimethyl benzyl ammonium chloride, or a mixture of didecyl dimethyl ammonium bromide and n-alkyl dimethyl benzyl ammonium chloride, wherein the content of the didecyl dimethyl ammonium bromide is 60%, and the content of the n-alkyl dimethyl benzyl ammonium chloride is 40%.
The skin care agent is one or more of vitamin E, glycerol, allantoin, lanolin, water-soluble lanolin, aloe extract and rose extract.
The solvent is one or more than two of ethanol, isopropanol and deionized water.
The auxiliary materials comprise a pH value regulator, a surfactant and a thickening agent.
The pH value regulator is citric acid or sodium bicarbonate or triethanolamine or sodium hydroxide.
The surfactant is one or more of PEG-7 olive oil ester, PEG-7 olive oil sodium carboxylate, castor oil polyoxyethylene ether and sodium lauroyl glutamate.
The thickening agent is carbomer, pullulan, polyglutamic acid or xanthan gum, or a mixture of pullulan and polyglutamic acid at any ratio, wherein carbomer comprises carbomer 940, carbomer 941, carbomer 2020 and the like.
The sodium azulene sulfonate antiallergic no-clean quick-drying hand cleaner disclosed by the invention is glittering and translucent, has a crystal-like luster like blue and violet, is free from water washing, and integrates antibacterial, environment-friendly and skin-care functions. Not only can solve the problem of alcohol allergy of part of people existing in the products sold on the market, but also has the characteristics of quick action and convenient use. The working time can be saved, the benefit can be improved, and the user can be effectively protected. Is particularly suitable for medical staff, business personnel and tourists to carry out the sanitary disinfection of hands when the water is inconvenient to use.
The invention can quickly and effectively kill various virus and germs (avian influenza virus, hepatitis B virus, hepatitis C virus, intestinal pathogenic bacteria, escherichia coli, staphylococcus aureus, pathogenic yeast and the like) between palms and finger joints within 1 minute, and bacteria can not be bred in 4 hours after the hands are disinfected. More than 99 percent of antibacterial effect, 2ml for 1 time, and the hand can be quickly dried within 30 seconds to 1 minute. The product has pH value close to skin pH value, and has no toxicity or irritation to normal skin, good safety and high efficiency. The portable multifunctional health care pillow has the characteristics of being beneficial to environmental protection, convenient to carry and capable of being used at any time and any place; has no irritation and residue, and is suitable for public places such as medical institutions, banks, catering industry, entertainment places, schools, offices and the like, and is used in home, business and travel.
Detailed Description
The sodium azulene sulfonate antiallergic no-clean quick-drying hand cleaner of the invention is explained in detail by the following examples.
The invention relates to an antiallergic no-clean quick-drying hand cleaner of sodium azulene sulfonate, which comprises the following components: 0.1 to 4.5 percent of antibacterial agent; 0.1 to 20 percent of skin care agent; 0.1 to 3 percent of sodium azulene sulfonate; 0.5 to 15 percent of auxiliary material; the solvent is the rest. Wherein,
the antibacterial agent is trichloro hydroxyl diphenyl ether or chlorhexidine or quaternary ammonium salt.
The chlorhexidine is chlorhexidine gluconate or chlorhexidine acetate.
The quaternary ammonium salt is benzalkonium chloride or benzalkonium bromide or didecyl dimethyl ammonium chloride or bis (dodecyl dimethyl) ethylene diammonium bromide or n-alkyl dimethyl benzyl ammonium chloride, or a mixture of didecyl dimethyl ammonium bromide and n-alkyl dimethyl benzyl ammonium chloride, wherein the content of the didecyl dimethyl ammonium bromide is 60%, and the content of the n-alkyl dimethyl benzyl ammonium chloride is 40%.
The skin care agent is one or more of vitamin E, glycerol, allantoin, lanolin, water-soluble lanolin, aloe extract and rose extract.
The solvent is one or more than two of ethanol, isopropanol and deionized water.
The auxiliary materials comprise a pH value regulator, a surfactant and a thickening agent.
The pH value regulator is citric acid or sodium bicarbonate or triethanolamine or sodium hydroxide.
The surfactant is one or more of PEG-7 olive oil ester, PEG-7 olive oil sodium carboxylate, castor oil polyoxyethylene ether and sodium lauroyl glutamate.
The thickening agent is carbomer, pullulan, polyglutamic acid or xanthan gum, or a mixture of pullulan and polyglutamic acid at any ratio, wherein carbomer comprises carbomer 940, carbomer 941, carbomer 2020 and the like.
The sodium azulene sulfonate antiallergic no-clean quick-drying hand cleaner is aqueous or gelatinous liquid, and can also be extruded into foam through special packaging. Not only can quickly sterilize and protect hand skin from stimulation, but also can effectively relieve the sensitive symptoms of ethanol and isopropanol. The application method comprises directly applying or squeezing foam, kneading to dryness, and washing with water to achieve antibacterial and hand cleaning effects.
Examples are given below:
example 1
Example 2
Example 3
Example 4
Example 5
Example 6
Example 7
Example 8
Example 9
Example 10
Example 11
Example 12
Example 13
Example 14
Example 15
Example 16
Example 17
Example 18
Example 19
Example 20
Example 21
Example 22
Preparation of the above examples:
firstly, adding thickening agents such as carbomer, xanthan gum or pullulan and the like into hot water with the temperature of more than 65 ℃ under high-speed stirring to fully break up the carbomer, xanthan gum or pullulan and the like, then adding sodium azulene sulfonate and a solvent, and stirring uniformly; adding alcoholic solution of trichloro-hydroxy diphenyl ether or chlorhexidine acetate, stirring to obtain uniform liquid, adding other adjuvants such as pH regulator, cooling to room temperature, testing, and packaging.
Effect detection
Disinfection effect detection
According to the national index requirements of disinfection products, the sodium azulene sulfonate antiallergic no-clean quick-drying hand cleaner is tested by professional authoritative test institutions, and the sterilization effect detection of escherichia coli and staphylococcus aureus is carried out, and the detection results show that the sterilization rate reaches over 99 percent, and the microbial indexes are as follows:
skin irritation test
The product of the patent is tested according to the disinfection technical specification of the Ministry of public health of the people's republic of China (2002 edition) and the experimental technical specification of toxicology of disinfection products, and the result shows that: the stock solution is used for carrying out a plurality of times of complete skin irritation tests on the rabbits, the average value of the total integral is 0.09, the skin irritation index is 0-0.5, and the irritation strength is nonirritating.
Field test
330 healthy volunteers with half proportion of male and female and age between 18 and 55 are selected, the hand cleaning effect use test is carried out on the products of all the embodiments according to the requirements of the disinfection technical specification (2002 edition), the total number of natural bacteria colonies on hands before and after use is detected, the sterilization effect of the hand cleaner is compared, and the results are as follows:
the sodium azulene sulfonate antiallergic no-clean quick-drying hand cleaner is completely suitable for public places such as medical institutions, banks, catering industry, entertainment places, schools, offices and the like, and is used in households, business trips and travels.
Claims (1)
1. The sodium azulene sulfonate antiallergic no-clean quick-drying hand cleaner is characterized by comprising the following components: 1% of allantoin, 4.5% of chlorhexidine acetate, 3% of wool grease, 2% of vitamin E, 0.2% of sodium azulene sulfonate, 15% of sodium lauroyl glutamate, 0.5% of pullulan, 0.5% of polyglutamic acid and the balance of water.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510050435.1A CN104666285B (en) | 2015-01-30 | 2015-01-30 | The disposable quick-drying detergent for cleaning hand of sodium azulenesulfonate antiallergy |
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| CN201510050435.1A CN104666285B (en) | 2015-01-30 | 2015-01-30 | The disposable quick-drying detergent for cleaning hand of sodium azulenesulfonate antiallergy |
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| CN104666285A CN104666285A (en) | 2015-06-03 |
| CN104666285B true CN104666285B (en) | 2017-08-22 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2017240068B2 (en) | 2016-03-31 | 2022-12-15 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
| JP2019510036A (en) * | 2016-03-31 | 2019-04-11 | ゴジョ・インダストリーズ・インコーポレイテッド | A detergent composition comprising probiotic / prebiotic active ingredients |
| EP3544575A1 (en) | 2016-11-23 | 2019-10-02 | GOJO Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| CN111518637B (en) * | 2020-03-18 | 2021-07-20 | 威莱(广州)日用品有限公司 | Strong-effect sterilization long-acting bacteriostatic washing fragrance retaining bead and preparation method thereof |
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| US6383997B1 (en) * | 2001-07-02 | 2002-05-07 | Dragoco Gerberding & Co. Ag | High lathering antibacterial formulation |
| JP2006512304A (en) * | 2002-05-20 | 2006-04-13 | ウィリアム， オー． クリング， | Skin cleansing composition and method of use |
| CN100389106C (en) * | 2005-01-10 | 2008-05-21 | 天津市顶硕科贸有限公司 | Process for synthesizing stable sodium azulene sulfonate |
| US9381150B2 (en) * | 2008-03-07 | 2016-07-05 | Kimberly-Clark Worldwide, Inc. | Alcohol antimicrobial skin sanitizing compositions including cationic compatible thickeners |
| CN101766552B (en) * | 2010-01-20 | 2011-12-07 | 浙江焜之琳生物医药科技股份有限公司 | Washing-free antibacterial hand sanitizer and preparation method thereof |
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Effective date of registration: 20160222 Address after: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Applicant after: Tianjin top pharmaceutical technology Co., Ltd. Address before: 300380 Tianjin city Xiqing District Zhangjiawo Industrial Zone Fengze Road No. 6 Applicant before: Tianjin Jing Shuo Science and Trade Co., Ltd. |
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Address after: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Applicant after: Tianjin top pharmaceutical Limited by Share Ltd Address before: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Applicant before: Tianjin top pharmaceutical technology Co., Ltd. |
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Denomination of invention: Sodium azulene sulfonate antiallergic wash free hand cleaner Effective date of registration: 20210318 Granted publication date: 20170822 Pledgee: Business Department of Bank of Tianjin Co.,Ltd. Pledgor: Tianjin top pharmaceutical Limited by Share Ltd. Registration number: Y2021120000008 |
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