CN103445983B - Novel biological sterilizing liquid soap - Google Patents
Novel biological sterilizing liquid soap Download PDFInfo
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- CN103445983B CN103445983B CN201310242677.1A CN201310242677A CN103445983B CN 103445983 B CN103445983 B CN 103445983B CN 201310242677 A CN201310242677 A CN 201310242677A CN 103445983 B CN103445983 B CN 103445983B
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- Prior art keywords
- polylysine
- epsilon
- liquid soap
- surfactant
- glycerol
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- 239000007788 liquid Substances 0.000 title abstract description 21
- 230000001954 sterilising effect Effects 0.000 title abstract description 14
- 239000000344 soap Substances 0.000 title abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- 108010039918 Polylysine Proteins 0.000 claims abstract description 16
- 241000894006 Bacteria Species 0.000 claims abstract description 10
- 239000004166 Lanolin Substances 0.000 claims abstract description 7
- 229940039717 lanolin Drugs 0.000 claims abstract description 7
- 235000019388 lanolin Nutrition 0.000 claims abstract description 7
- 239000004094 surface-active agent Substances 0.000 claims abstract description 6
- -1 dimethylamine amine Chemical class 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 8
- 230000002147 killing effect Effects 0.000 claims description 7
- 244000005700 microbiome Species 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 241000192125 Firmicutes Species 0.000 claims description 5
- 150000002596 lactones Chemical class 0.000 claims description 4
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 239000003002 pH adjusting agent Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 3
- 235000011152 sodium sulphate Nutrition 0.000 claims description 3
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 claims description 2
- 239000003206 sterilizing agent Substances 0.000 abstract description 4
- 241000193830 Bacillus <bacterium> Species 0.000 abstract description 2
- 241000233866 Fungi Species 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 231100000344 non-irritating Toxicity 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 13
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 6
- 230000003115 biocidal effect Effects 0.000 description 5
- 241000228245 Aspergillus niger Species 0.000 description 3
- 239000004155 Chlorine dioxide Substances 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 235000019398 chlorine dioxide Nutrition 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 238000007046 ethoxylation reaction Methods 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003559 chemosterilizing effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a liquid soap comprising a novel biological sterilizing agent epsilon-polylysine. The biological sterilizing agent epsilon-polylysine in the liquid soap has broad spectrum bacteriostatic action, and can restrain and kill gram-negative bacterium, gram-positive bacterium, fungus and heat resisting bacillus. The novel biological sterilizing liquid soap comprises a surfactant, a biological sterilizing agent, glycerol, acetylated lanolin and an additive, and is safe and reliable and nonirritating.
Description
Technical field
The invention belongs to field of hygiene products, relate to a kind of handwashing liquid containing novel biological bactericide epsilon-polylysine.
Background technology
People are in daily routines, and hands constantly contacts various things.And in these things, mostly containing a large amount of microorganisms, be wherein no lack of containing many pathogenic bacterium.Simultaneously along with the development of market economy, the social communication of people is also increasing.Many source of disease bacterium can be infected by the contact of hands.
At present, handwashing liquid as a kind of daily articles for washing receive by increasing consumer, and entered into huge numbers of families, can effectively avoid the advantage of cross-contamination also to become the first-selection of public place articles for washing because handwashing liquid in use has simultaneously.But different places is different to the function of handwashing liquid and the requirement of character.On market, current majority is the handwashing liquid of simple function, and can only remove spot, to microorganism without killing action, or killing action is very little, can not adapt to the requirement in more and more extensively market.Market also occurs some have the handwashing liquid of disinfecting and sterilizing functions.Mainly with the addition of some chemosterilants, make handwashing liquid have certain bactericidal effect.A kind of disinfection hand cleanser containing chlorine dioxide of patent of invention as Authorization Notice No. CN 101766543B, its antibacterial is chlorine dioxide.Although chlorine dioxide bactericidal effect is good, have intense stimulus, mainly cause eye and respiratory tract after contact, sucking high concentration can there is pulmonary edema, can be lethal.Patent CN 101475879B sterilizing skin-protective hand cleanser take parachlorometaxylenol as antibacterial, has zest and the stronger shortcoming of toxicity equally.In order to overcome the shortcoming of chemical bactericide, patent CN 101966134B sterilizing skin-protective hand cleanser and preparation method thereof discloses in one the handwashing liquid adopting Nipagin ester as antibacterial, but Nipagin ester dissolubility in water is extremely low, product homogeneity and poor stability.Patent of invention CN 102600053B Chinese medicinal herb-inorganic antibacterial agent composite sterilization hand sanitizer and preparation adopt Folium Artemisiae Argyi, Herba Artemisiae Annuae, Radix Scutellariae, Pericarpium Granati, Radix Glycyrrhizae water extract be composite Chinese herbal antibacterial, be equipped with inorganic antiseptic nano phase ag_2 o to use, but make complicated, antimicrbial power is low, in order to prevent putrid and deterioratedly also needing autoclaving.So market is starved of a kind of dirt-removing power good, sterilizing power is strong, safe and reliable handwashing liquid.
This handwashing liquid adopts the epsilon-polylysine of fermentable production as antibacterial, the advantages such as it has safety non-toxic, good water solubility, heat stability is high, antimicrobial spectrum is wide.Epsilon-polylysine (ε-poly-lysine) is a kind of aminoacid homopolymer with broad spectrum antibiotic activity, there is good sterilizing ability and heat stability, in neutrality and acid range, fungistatic effect is good, has remarkable inhibitory action to various gram-positive bacterium, gram negative bacteria and heat-resistant bacillus, mycete, virus etc.Again because of the homopolymer that epsilon-polylysine is made up of lysine, can be used as food additive application, even if accidentally eat by mistake, also there is no toxic and side effects.
Summary of the invention
The object of this invention is to provide a kind of has a broad antifungal spectrum containing epsilon-polylysine, sterilizing power by force, new bio disinfection hand cleanser safely and efficiently.
The mass percent of each component of new bio disinfection hand cleanser is: glycerol 1 ~ 5, acetylated lanolin 1 ~ 3, surfactant 8 ~ 30, epsilon-polylysine 0.05 ~ 0.5, pH adjusting agent 0 ~ 3, essence 0.1 ~ 0.3, and all the other are deionized water.Due to containing biofungicide epsilon-polylysine, thus all there is killing action to gram positive bacteria, gram negative bacteria, eukaryotic microorganisms and virus, simultaneously to no skin irritation, safe and reliable.Surfactant is one or more mixing in sodium lauryl sulphate, ammonium lauryl sulfate, polyoxyethylenated alcohol sodium sulfate, AESA, cocoamidopropyl dimethylamine amine second lactone, ethoxylation cocoamidopropyl dimethyl quaternary ammonium salt, strong detergency.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1:
By each constituent content of handwashing liquid weight percent meter:
Glycerol, acetylated lanolin, cocoamidopropyl dimethylamine amine second lactone, ethoxylation cocoamidopropyl dimethyl quaternary ammonium salt is added in deionized water; be heated to 55 ~ 60 DEG C; stir; be cooled to room temperature; adjust PH to 5.5 ~ 6.5 with citric acid, then add biofungicide epsilon-polylysine, essence, stir; degassed, subpackage.
Table 1 biological antibiotic handwashing liquid (5% diluent) 1 minute bactericidal effect
| Strain | Escherichia coli | Staphylococcus aureus | Saccharomyces cerevisiae | Aspergillus niger |
| Sterilizing rate (%) | 100 | 100 | 99.98 | 99.92 |
All have good killing action to gram positive bacteria, gram negative bacteria, eukaryotic microorganisms, sterilizing rate is all more than 99.9%.
Embodiment 2:
By each constituent content of handwashing liquid mass percent:
Glycerol, acetylated lanolin, cocoamidopropyl dimethylamine amine second lactone, polyoxyethylenated alcohol sodium sulfate is added in deionized water; be heated to 55 ~ 60 DEG C; stir; be cooled to room temperature; adjust pH to 5.5 ~ 6.5 with hydrochloric acid, then add biofungicide epsilon-polylysine, essence, stir; degassed, subpackage.
Table 2 biological antibiotic handwashing liquid (5% diluent) 1 minute bactericidal effect
| Strain | Escherichia coli | Staphylococcus aureus | Saccharomyces cerevisiae | Aspergillus niger |
| Sterilizing rate (%) | 100 | 99.97 | 99.93 | 99.82 |
All have good killing action to gram positive bacteria, gram negative bacteria, eukaryotic microorganisms, sterilizing rate is all more than 99.8%.
Embodiment 3:
By each constituent content of handwashing liquid mass percent:
Glycerol, acetylated lanolin, ethoxylation cocoamidopropyl dimethyl quaternary ammonium salt, AESA is added in deionized water; sodium lauryl sulphate; be heated to 55 ~ 60 DEG C; stir, be cooled to room temperature, adjust pH to 5.5 ~ 6.5 with hydrochloric acid; then biofungicide epsilon-polylysine, essence is added; stir, degassed, subpackage.
Table 3 biological antibiotic handwashing liquid (5% diluent) 1 minute bactericidal effect
| Strain | Escherichia coli | Staphylococcus aureus | Saccharomyces cerevisiae | Aspergillus niger |
| Sterilizing rate (%) | 100 | 99.98 | 99.96 | 99.85 |
Average bactericidal rate reaches more than 99.8%, all has good killing action to gram positive bacteria, gram negative bacteria, eukaryotic microorganisms.
More than show and describe ultimate principle of the present invention, principal character.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; do not departing under the spirit and scope of the present invention prerequisite; the present invention also has various changes and modifications, and these changes and improvements fall in the claimed scope of the invention.
Claims (2)
1. a disinfection hand cleanser, is characterized in that, containing biofungicide epsilon-polylysine, all having killing action to gram positive bacteria, gram negative bacteria, eukaryotic microorganisms and virus; The mass percent of each component is: glycerol 1 ~ 5%, acetylated lanolin 1 ~ 3%, surfactant 8 ~ 30%, epsilon-polylysine 0.05 ~ 0.5%, pH adjusting agent 0 ~ 3%, essence 0.1 ~ 0.3%, and all the other are deionized water; Described surfactant is one or more mixing in sodium lauryl sulphate, ammonium lauryl sulfate, polyoxyethylenated alcohol sodium sulfate, AESA, cocoamidopropyl dimethylamine amine second lactone.
2. the preparation method of disinfection hand cleanser according to claim 1 is: in deionized water, add glycerol, acetylated lanolin, surfactant; be heated to 55 ~ 60 DEG C; stir; be cooled to room temperature; adjust pH to 5.5 ~ 6.5 with pH adjusting agent citric acid or hydrochloric acid, then add biofungicide epsilon-polylysine, essence, stir; degassed, subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310242677.1A CN103445983B (en) | 2013-06-19 | 2013-06-19 | Novel biological sterilizing liquid soap |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310242677.1A CN103445983B (en) | 2013-06-19 | 2013-06-19 | Novel biological sterilizing liquid soap |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103445983A CN103445983A (en) | 2013-12-18 |
| CN103445983B true CN103445983B (en) | 2015-06-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310242677.1A Expired - Fee Related CN103445983B (en) | 2013-06-19 | 2013-06-19 | Novel biological sterilizing liquid soap |
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| Country | Link |
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| CN (1) | CN103445983B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105543256A (en) * | 2016-01-12 | 2016-05-04 | 天津科技大学 | Lyase of bacteriophage and sterilization application |
| CN106265098A (en) * | 2016-09-18 | 2017-01-04 | 天津北洋百川生物技术有限公司 | A kind of perfume patch of health environment-friendly and preparation method thereof |
| CN107308034A (en) * | 2017-05-26 | 2017-11-03 | 安徽肤彩生物科技有限公司 | A kind of special hand cleanser of women and infants |
| CN108567587A (en) * | 2018-07-15 | 2018-09-25 | 胡南南 | A kind of nursing thimerosal |
| CN112245327B (en) * | 2020-11-27 | 2021-06-22 | 苏州承芃和医药科技有限公司 | Antibacterial composition, mouthwash and preparation method of mouthwash |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222346A (en) * | 1998-01-09 | 1999-07-14 | 陈又红 | Antiseptic disinfecting skin care hand-washing liquid |
| CN102973440A (en) * | 2011-09-05 | 2013-03-20 | 付淑珍 | Antimicrobial and disinfectant hand sanitizer and preparation method thereof |
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- 2013-06-19 CN CN201310242677.1A patent/CN103445983B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN103445983A (en) | 2013-12-18 |
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Granted publication date: 20150617 |