CN103251516A - Preparation method of skin-care disinfecting and sterilizing hand sanitizer - Google Patents
Preparation method of skin-care disinfecting and sterilizing hand sanitizer Download PDFInfo
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- CN103251516A CN103251516A CN2013101774683A CN201310177468A CN103251516A CN 103251516 A CN103251516 A CN 103251516A CN 2013101774683 A CN2013101774683 A CN 2013101774683A CN 201310177468 A CN201310177468 A CN 201310177468A CN 103251516 A CN103251516 A CN 103251516A
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Abstract
The invention relates to a preparation method of a skin-care disinfecting and sterilizing hand santilizer. The method comprises the following steps of: mixing and cold stirring 8-12% of polydatin and 75-90% of deionized water for 1 hour, heating to normal temperature, adding 3-8% of sodium copper chlorophyllin and 1-3% of glycerol, heating to 40 DEG C, stirring for 1 hour, cooling to normal temperature, adding essence, adjusting pH to 7.5-8.0 with citric acid, and stirring uniformly to obtain a product. The hand sanitizer developed according to the invention is clear, transparent, and fragrant in smell. The pH is 6-8, which is closest to a skin environment. The adopted decontaminating and sterilizing component has little harm to skin, and the natural sodium copper chlorophyllin and glycerol can repair damaged skin and moisturize skin, so that skin is well protected. The product is a good choice of protecting hand skin for medical workers who often wash hands with the water sanitizer, and is also suitable for being used for washing hand by bank note counting workers, hygiene and epidemic prevention workers and hotel attendants.
Description
Technical field
The present invention relates to a kind of handwashing liquid, especially relate to a kind of handwashing liquid with natural skin care disinfection.
Background technology
People's hand-washing article in the past mainly is soap, fancy soap etc., easy landing when they use, and chance water logging, high temperature can soften again and expend naturally, especially easily are infected with on hand dirt, antibacterial, become the secondary pollution source.Along with the transformation of growth in the living standard and consumption idea, handwashing liquid becomes the succedaneum of traditional hand-washing article gradually, and oneself is widely used in various places such as hospital, hotel, food and drink, family at present.The contact surface of handwashing liquid and hands generally is the bottle pump head, and is easy to clean, avoided cross infection.By the squash type amount of getting, only need one press nozzle gently, liquid just flows into the palm of the hand, and consumption is by own grasp, and it is all very convenient to deposit use.
Nowadays, along with the maturation of handwashing liquid production technology and popularizing of market, the special-purpose handwashing liquid with various special efficacies has also constantly come out.As the heavy duty detergent handwashing liquid, except paint handwashing liquid, anhydrous washing hand liquid, disinfection handwashing liquid etc.Wherein, the disinfection handwashing liquid is a class of occupancy volume maximum in the special-purpose handwashing liquid in market.
It is reported, the disinfection handwashing liquid that generally uses on the present market, the effect aspect disinfection is more satisfactory.But considering not good enoughly aspect the nursing of hand skin, the component of disinfection is bigger to the zest of skin, life-time service cause easily the hand skin drying, coarse, religion is split and peel.
Handwashing liquid diverse in function on the market, cleaning, degerming, virus killing, skin protection, but need a kind of compound handwashing liquid to solve these defect problems, we have developed skin-protection type disinfection handwashing liquid, to remedy this kind deficiency of this series products.The skin-protection type disinfection handwashing liquid of this research development, changed the method for in the past adding special disinfectant, and adopt existing dirt-removing power to have the natural plant extracts of bactericidal effect composite, reduced that skin is produced composition and the effective skin protection of content that stimulates, to reduce the infringement to skin to greatest extent.
Summary of the invention
The present invention is more sufficient above-mentioned deficiency, provides a kind of stain removal bactericidal ability by force, skin not to be caused the skin-protection type disinfection handwashing liquid of stimulation and injury.
A kind of preparation method of skin-protection type disinfection handwashing liquid, be with
Polydatin 8-12% and deionized water 75-90% mix cold stirring 1 hour, rise to room temperature, add sodium copper chlorophllin 3-8%, glycerol 1-3% again and are warming up to 40 ℃, stirred 1 hour, and be down to room temperature, adding essence is an amount of, an amount of Fructus Citri Limoniae acid for adjusting pH to 7.5～8.0 stir, and namely get product.
The percentage ratio of all components that relate among the present invention is weight percentage.
In the present invention, polydatin, namely 3,4,5-resveratrol-3-O-β-D glucoside, for the diphenylethylene compounds polydatin distributes in plant extensively, content is higher, has at least found polydatin at present surplus 70 in the kind of plant.Have multiple biological activitys such as antibacterium, antifungal virus killing.The present invention substitutes common disinfection component with the polydatin of natural extract, and not only effect is obvious, and chafe not, pure natural components.Add some cationic and anionic surfactants as antibacterial in the general disinfection hand cleanser, dirt-removing power is very strong, but its degreasing power is also very strong, and the skin surface oily components is reduced.Too much also can destroy nature moisturizing factor in the skin that aminoacid and low molecular weight protein form, cause moisture-keeping functions to descend, the protein distortion causes physiologically active to hinder, show as skin stop split, dry, coarse.Through experimental study, the polydatin component ratio is 8-12%, and the present invention selects for use 10% to be the best composition ratio.
In the present invention, be raw material with the South America Herbia Wedeliae, extract the natural chlorophyll copper sodium in the Herbia Wedeliae, make and have antibacterial, skin moistening effect.So both can solve the problem that the South America Herbia Wedeliae spreads unchecked everywhere, can benefit the people with it as the raw material of producing handwashing liquid again simultaneously.After deliberation, the sodium copper chlorophllin component ratio is 3-8%, and the present invention selects 6% ratio for use.
Polydatin and natural chlorophyll copper sodium all have bactericidal, and chafe not moistens the effect of skin protection.
The method for preparing ingredients thereof of selecting for use of the present invention is, polydatin 10% and deionized water 80% mix cold stirring 1 hour, rise to room temperature, add sodium copper chlorophllin 6% again, glycerol 3% is warming up to 40 ℃, stirred 1 hour, and be down to room temperature, adding essence is an amount of, an amount of Fructus Citri Limoniae acid for adjusting pH to 7.5～8.0 stir, and namely get product.
The handwashing liquid of the present invention's development, clear, fragrant odour.The pH value is 6-8, near the skin environment.Selected decontamination, bactericidal component are minimum to skin damage, and natural polydatin, sodium copper chlorophllin, glycerol more can in time be repaired and decreased skin and skin is preserved moisture, and skin is well protected.The medical worker that this product often uses handwashing liquid to wash one's hands to need is the fine selection of a protection hand skin, also is applicable to the usefulness that the counting personnel of bank, health and epidemic prevention personnel, hotel service personal wash one's hands simultaneously.
Embodiment 1
Producing of sodium copper chlorophllin: take by weighing 10 g after the leaf pretreatment is handled and add 95% ethanol, heating in water bath 50 min, decompress filter by the solid-liquid ratio of 1 ︰ 20, filtrate is regulated pH to 12 ~ 13 with NaOH, keeps 1 h with 70 ℃ of heating in water bath, concentrates, with petroleum ether extraction 2 times, HCl regulates pH=2.Add CuSO4,70 ℃ of water bath with thermostatic control 60 min, centrifugal, washing.
The preparation of handwashing liquid: polydatin 10g and deionized water 80g mix cold stirring 1 hour, rise to room temperature, add sodium copper chlorophllin 6g, glycerol 3g again and be warming up to 40 ℃, stirred 1 hour, be down to room temperature, it is an amount of to add essence, and an amount of Fructus Citri Limoniae acid for adjusting pH to 7.5～8.0 stir, and namely get product.Sterilizing rate 99%.
Embodiment 2
Producing of sodium copper chlorophllin: take by weighing 10 g after the leaf pretreatment is handled and add 95% ethanol, heating in water bath 50 min, decompress filter by the solid-liquid ratio of 1 ︰ 20, filtrate is regulated pH to 12 ~ 13 with NaOH, keeps 1 h with 70 ℃ of heating in water bath, concentrates, with petroleum ether extraction 2 times, HCl regulates pH=2.Add CuSO4,70 ℃ of water bath with thermostatic control 60 min, centrifugal, washing.
The preparation of handwashing liquid: polydatin 8g and deionized water 82g mix cold stirring 1 hour, rise to room temperature, add sodium copper chlorophllin 6g, glycerol 3g again and be warming up to 40 ℃, stirred 1 hour, be down to room temperature, it is an amount of to add essence, and an amount of Fructus Citri Limoniae acid for adjusting pH to 7.5～8.0 stir, and namely get product.Sterilizing rate 88%.
Embodiment 3
Producing of sodium copper chlorophllin: take by weighing 10 g after the leaf pretreatment is handled and add 95% ethanol, heating in water bath 50 min, decompress filter by the solid-liquid ratio of 1 ︰ 20, filtrate is regulated pH to 12 ~ 13 with NaOH, keeps 1 h with 70 ℃ of heating in water bath, concentrates, with petroleum ether extraction 2 times, HCl regulates pH=2.Add CuSO4,70 ℃ of water bath with thermostatic control 60 min, centrifugal, washing.
The preparation of handwashing liquid: polydatin 12g and deionized water 81g mix cold stirring 1 hour, rise to room temperature, add sodium copper chlorophllin 6g, glycerol 3g again and be warming up to 40 ℃, stirred 1 hour, be down to room temperature, it is an amount of to add essence, and an amount of Fructus Citri Limoniae acid for adjusting pH to 7.5～8.0 stir, and namely get product.Sterilizing rate 98%.
Embodiment 4
Producing of sodium copper chlorophllin: take by weighing 10 g after the leaf pretreatment is handled and add 95% ethanol, heating in water bath 50 min, decompress filter by the solid-liquid ratio of 1 ︰ 20, filtrate is regulated pH to 12 ~ 13 with NaOH, keeps 1 h with 70 ℃ of heating in water bath, concentrates, with petroleum ether extraction 2 times, HCl regulates pH=2.Add CuSO4,70 ℃ of water bath with thermostatic control 60 min, centrifugal, washing.
The preparation of handwashing liquid: polydatin 10g and deionized water 83g mix cold stirring 1 hour, rise to room temperature, add sodium copper chlorophllin 3g, glycerol 3g again and be warming up to 40 ℃, stirred 1 hour, be down to room temperature, it is an amount of to add essence, and an amount of Fructus Citri Limoniae acid for adjusting pH to 7.5～8.0 stir, and namely get product.The product that obtains is smooth to the touch, and moisturizing effect is good.
Embodiment 5
Producing of sodium copper chlorophllin: take by weighing 10 g after the leaf pretreatment is handled and add 95% ethanol, heating in water bath 50 min, decompress filter by the solid-liquid ratio of 1 ︰ 20, filtrate is regulated pH to 12 ~ 13 with NaOH, keeps 1 h with 70 ℃ of heating in water bath, concentrates, with petroleum ether extraction 2 times, HCl regulates pH=2.Add CuSO4,70 ℃ of water bath with thermostatic control 60 min, centrifugal, washing.
The preparation of handwashing liquid: polydatin 10g and deionized water 78g mix cold stirring 1 hour, rise to room temperature, add sodium copper chlorophllin 8g, glycerol 3g again and be warming up to 40 ℃, stirred 1 hour, be down to room temperature, it is an amount of to add essence, and an amount of Fructus Citri Limoniae acid for adjusting pH to 7.5～8.0 stir, and namely get product.The product that obtains is smooth to the touch, and moisturizing effect is good.
The test of embodiment 1 recruitment evaluation
Bactericidal effect
Adopt staphylococcus aureus A T CC 65 38, escherichia coli 80 99, Mycobacterium chelonei abscess subspecies A T CC 93 32 6
, strain preparation bacteria suspension such as Candida albicans AT CC 102 31, carry out the bactericidal assay operation by Ministry of Health of the People's Republic of China's " disinfection technology standard ".Result of the test shows, this handwashing liquid stock solution in 1 minute to the killing rate of staphylococcus aureus, escherichia coli, Testudinis branch bar, the swollen subspecies of bacterial ooze, Candida albicans etc. more than 99 %.Suspension is quantitatively killed logarithm value all 〉=8.00; Carrier quantitation is killed logarithm value all 〉=5.00, illustrates that this handwashing liquid meets the requirement of disinfection fully.
The toxicity test
Select the healthy mice of body weight 20-25g, male and female half and half are divided into 2 times ~ 3 times and give the handwashing liquid stock solution that accumulated dose is 10g/kg in 24 h, adopt administration by gavage, are inserted into the white mouse gastric with syringe and inject.Observed seven days continuously, abnormal symptom is not seen in none death of white mice.Result of the test shows, handwashing liquid stock solution to the LD50 of male and female white mice all greater than 10g/kg, the nontoxic level in true border.
The skin irritation test
Select 3 intact healthy rabbits of 2kg left and right sides skin, remove with the hair of depilatory with tame rabbit back spinal column both sides, must not injured skin.The unhairing scope, left and right each about 3 cm x, 3 c m.Pick handwashing liquid stock solution with cotton swab and smear on the unhairing intact skin of rabbit one side, use the residual handwashing liquid of warm water flush away behind 4 h.Rabbit opposite side skin of unhairing is smeared once as blank every day, smears 14 d continuously.Smearing back 24 h observed results at every turn.Test shows, 3 rabbit skin of back none produce redness, inflammation, phenomenon, experimental group and matched group indifference such as fester.Prove that this handwashing liquid is to the skin nonirritant.
Disinfection Effect
Randomly draw 20 medical care personnel, be divided into two groups, every group ten, use the test that carries out disinfection of common anion and cation disinfection hand cleanser and natural plant composition handwashing liquid of the present invention respectively, result of the test, the zwitterion disinfection hand cleanser detects on hand and deposits viable count is 11 cfu/cm2, and natural handwashing liquid of the present invention detects on hand and deposits viable count is 9 cfu/cm2.Disinfection Effect is obvious.
Claims (2)
1. skin-protection type disinfection handwashing liquid preparation method, it is characterized in that it being to stir 1 hour under polydatin 8-12% and the deionized water 75-90% mixing back condition of ice bath, rise to room temperature, add sodium copper chlorophllin 3-8%, glycerol 1-3% again and be warming up to 40 ℃, stirred 1 hour, and be down to room temperature, add essence, and Fructus Citri Limoniae acid for adjusting pH to 7.5～8.0 stir, and namely get product.
2. skin-protection type disinfection handwashing liquid preparation method according to claim 1 is characterized in that described polydatin content is 10%.
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| CN201310177468.3A CN103251516B (en) | 2013-05-15 | 2013-05-15 | Preparation method of skin-care disinfecting and sterilizing hand sanitizer |
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| CN201310177468.3A CN103251516B (en) | 2013-05-15 | 2013-05-15 | Preparation method of skin-care disinfecting and sterilizing hand sanitizer |
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| CN103251516B CN103251516B (en) | 2014-08-06 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622741A (en) * | 2015-01-14 | 2015-05-20 | 杨祝华 | Skin caring and moisturizing hand cleaner |
| CN105503970A (en) * | 2015-11-27 | 2016-04-20 | 淮阴工学院 | Polydatin ester derivative, preparation method and application thereof |
| CN109833218A (en) * | 2019-04-18 | 2019-06-04 | 北京林业大学 | A kind of polydatin multiple-effect whitening mask and preparation method thereof |
| US10456343B2 (en) | 2017-01-26 | 2019-10-29 | L'oreal | Microemulsion compositions comprising polydatin and method of use |
| CN113520940A (en) * | 2021-07-07 | 2021-10-22 | 苏州麻朵纺织科技有限公司 | Natural plant-extracted disinfection type hand sanitizer with natural antibacterial and antiviral functions |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559031A (en) * | 2008-04-14 | 2009-10-21 | 北京健健康康生物技术有限公司 | Skin-building toilet water rich in sodium copper chlorophyllin and preparation method thereof |
| CN102805831A (en) * | 2012-08-16 | 2012-12-05 | 王爱 | Medical disinfectant and preparing method thereof |
-
2013
- 2013-05-15 CN CN201310177468.3A patent/CN103251516B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559031A (en) * | 2008-04-14 | 2009-10-21 | 北京健健康康生物技术有限公司 | Skin-building toilet water rich in sodium copper chlorophyllin and preparation method thereof |
| CN102805831A (en) * | 2012-08-16 | 2012-12-05 | 王爱 | Medical disinfectant and preparing method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 周卫花等: "南美蟛蜞菊洗手液的研制", 《广东化工》, vol. 37, no. 212, 31 December 2010 (2010-12-31), pages 40 - 47 * |
| 张喜云: "虎杖的化学成分、药理作用与提取分离", 《天津药学》, vol. 11, no. 3, 31 August 1999 (1999-08-31), pages 13 - 14 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622741A (en) * | 2015-01-14 | 2015-05-20 | 杨祝华 | Skin caring and moisturizing hand cleaner |
| CN105503970A (en) * | 2015-11-27 | 2016-04-20 | 淮阴工学院 | Polydatin ester derivative, preparation method and application thereof |
| CN105503970B (en) * | 2015-11-27 | 2018-07-13 | 淮阴工学院 | A kind of polydatin ester derivative and its preparation method and application |
| US10456343B2 (en) | 2017-01-26 | 2019-10-29 | L'oreal | Microemulsion compositions comprising polydatin and method of use |
| CN109833218A (en) * | 2019-04-18 | 2019-06-04 | 北京林业大学 | A kind of polydatin multiple-effect whitening mask and preparation method thereof |
| CN113520940A (en) * | 2021-07-07 | 2021-10-22 | 苏州麻朵纺织科技有限公司 | Natural plant-extracted disinfection type hand sanitizer with natural antibacterial and antiviral functions |
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| CN103251516B (en) | 2014-08-06 |
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