CN104095789A - Special Chinese honey locust liquid soap used in clinical laboratory and preparation method thereof - Google Patents
Special Chinese honey locust liquid soap used in clinical laboratory and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a special Chinese honey locust liquid soap used in a clinical laboratory and the preparation method thereof. The liquid soap comprises functional components, organic acid, a hard water resisting agent, a pure plant spice, a thickening agent and deionized water. The functional components are a Chinese honey locust extractive, a plant acid liquid and aloe-emodin; the organic acid adopts citric acid, Chinese honey locust has a bacterial inhibition effect, the saponin component contained in the Chinese honey locust can lower surface stress, the foaming is long lasting, the cleaning effect is good, the plant acid liquid is acidic, has a broad-spectrum bactericidal effect, and has a remarkable antiinflammation and antipruritic effects, and the citric acid is used for preparing a buffering solution, is taken as a builder, can improve the performance of washed products, and can improve the performance of a surface active agent. According the special Chinese honey locust liquid soap, the formula is reasonable, the preparation process is simple, the cost is low, the smell is fragrant, the sterilizing and disinfecting effects are obvious, a skin care effect is played, and the special Chinese honey locust liquid soap is specially provided for patients receiving examinations and staffs in the clinical laboratory, can eliminate influences from various germs and further improve the examining accuracy.
Description
Technical field
The present invention relates to medical nursing field, particularly relate to special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory and preparation method thereof.
Background technology
Medically needing that sufferer is extracted to specimen detects, could go out suffered from disease by Accurate Diagnosis, clinical laboratory is the bridge between clinical medicine and preclinical medicine, comprise clinical chemistry, clinical microbiology, clinical immunology, hematology, the subdiscipline such as osology and transfusion science, clinical laboratory bears and comprise ward every day, door emergency case, the task of the various human bodies of all kinds of health check-ups and scientific research and the detection of zoological specimens chemical examination, must ensure the accuracy of inspection, so inspection work should ensure to carry out under aseptic condition, to eliminate antibacterial, fungus, the impact of pathogenic microorganism.So the staff of clinical laboratory and the sufferer accepting inspection need to be cleaned and sterilize both hands.
At present, existing handwashing liquid does not possess good sterilizing effect, and the general method adopting is that both hands are immersed in disinfectant solution, and existing disinfectant solution is mainly ethanol, hydrogen peroxide, and iodine tincture, potassium permanganate, also has glutaraldehyde, povidone iodine etc.These disinfectant solution are mostly chemicals, have strong impulse, and life-time service can seriously stimulate medical personnel's skin, the people of some skin sensitivities, and both hands surface can become dry and crowfoot cracks, and dermatitis and eczema even can occur.And reusing of disinfectant solution developed immunity to drugs antibacterial etc., have a strong impact on Disinfection Effect, not only increase reviewer's work difficulty, also affect the result of inspection.For this reason, find a kind of wide spectrum that sterilizes, sterilizing ability is strong, speed of action is fast, good stability, zest are little, soluble in water, significant for the every inspection work of clinical laboratory to humans and animals safety and the handwashing liquid that can sterilize and can skin protection cheap and easy to get.
Summary of the invention
The technical problem that the present invention solves is: special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory and preparation method thereof is provided, and this handwashing liquid can be sterilized and can skin protection, and rationally, preparation technology is simple for formula, for checking system provides good environment, ensures the accuracy of assay.
Technical scheme of the present invention is: the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory, comprise functional components 24-40 part, organic acid 1-3 part, anti-hard water agent 0.1-0.2 part, thickening agent 0.15-0.35 part, pure plant perfume 0.2-0.5 part, deionized water 40-60 part, described functional components is Fructus Gleditsia extract, plant vinegar liquid, aloe-emodin.
Further, the weight portion of described functional components is respectively: Fructus Gleditsia extract 22-30 part, plant vinegar liquid 1.5-5.5 part, aloe-emodin 0.5-3.5 part.
Particularly, the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory, comprise 32 parts of functional components, 2 parts of organic acid, 0.15 part of anti-hard water agent, 0.25 part of thickening agent, 0.35 part of pure plant perfume, 50 parts of deionized waters, described functional components is Fructus Gleditsia extract, plant vinegar liquid, aloe-emodin.The weight portion of described functional components is respectively: 26 parts of Fructus Gleditsia extracts, 3.5 parts of plant vinegar liquids, 2.0 parts of aloe-emodins.
Further, the selected raw material of described Fructus Gleditsia extract is Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, and its ratio is 2: 4: 1.The pod of Gleditsia officinalis, seed, scolus etc. all can be used as medicine, they not only have antibacterial action, and its Saponin containing can reduce surface tension, and in its solution solution, the surface of each bubble all can be surrounded by Saponin and form a thin film, and foam does not go out lastingly, be applicable to very much preparing handwashing liquid.
Further, described plant vinegar liquid is one or more mixture in Bamboo vinegar solution, wood vinegar and CAOSU liquid.Bamboo vinegar solution, wood vinegar and CAOSU liquid are acidity, there is broad-spectrum bactericidal action, under high concentration, there is stronger sterilization, antibacterial function, under low concentration, can suppress the breeding of miscellaneous bacteria, have fungi-proofing, effect of insect protected, can be used for the treatment of dermatitis, beriberi, pruritus disease, remarkable to itch stopping and diminish inflammation effect.
Preferably, described organic acid is citric acid.Citric acid can be in order to prepare buffer solution on chemical technology, adopt citric acid or citric acid salt to make builder, can improve the performance of cleaning product, precipitate metal ion rapidly, prevent that pollutant are re-attached on fabric, make dirt and ash disperse and suspend, improve the performance of surfactant, it is a kind of good intercalating agent, citric acid belongs to the one of fruit acid, Main Function is to accelerate cutin to upgrade, be usually used in emulsion, cream, shampoo, whitening articles for use, aging resistance articles for use, Acne etc., the renewal of cutin contribute to skin in melanic peeling off, the contraction of pore, the dissolving of blackhead etc.
Described Fructus Gleditsia extract, its preparation method is: take in proportion Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, Fructus Gleditsia fruit and Fructus Gleditsia acupuncture are ground into coarse powder, be placed in boiler together with Folium Gleditsiae, add water to and exceed medical material upper surface 5-8cm, big fire is boiled to boiling, changing slow fire boiling extracts 2-3 time, each 1-2 hour that extracts, impurity, merging filtrate are removed in hyperfiltration, be evaporated to the extractum that relative density is 0.85-0.96, except color, obtain water white transparency extractum with activated carbon adsorption, be Fructus Gleditsia extract.
The special Fructus Gleditsia handwashing liquid of described a kind of clinical laboratory, its preparation method is: the deionized water that adds formula ratio in container, temperature is controlled at 22-28 DEG C, add successively again functional components, organic acid, anti-hard water agent, pure plant perfume, limit edged stirs, mixing speed is controlled at 30-50r/min, finally add thickening agent, described thickening agent is preferably Sodium Alginate, after stirring, still aging at 16-30 DEG C of temperature, after froth breaking to be de-gassed, carry out subpackage, the special Fructus Gleditsia handwashing liquid of Ji get clinical laboratory with handwashing liquid filling machine.
Beneficial effect of the present invention is:
Selected Fructus Gleditsia is the natural material of medicine food, health product, cosmetics and articles for washing, the pod of Gleditsia officinalis, seed, scolus etc. all can be used as medicine, Fructus Gleditsia has inhibitory action to some Gram-negative enteral pathogenic bacterium, its water logging agent also has inhibitory action to some dermatophytes, and trichophyton, star-shaped nocardia are had to inhibitory action.Its saponin component containing can reduce surface tension, when its solution (1: 10000) jolting, in solution, the surface of each bubble all can be surrounded by Saponin and form a thin film, foam does not go out lastingly, our ancestors bring into use Fructus Gleditsia hair washing very early, cleaning effect is fine, with it prepare handwashing liquid without add foaming agent;
Selected described Bamboo vinegar solution, wood vinegar and CAOSU liquid are acidity, there is broad-spectrum bactericidal action, under high concentration, there is stronger sterilization, antibacterial function, under low concentration, can suppress the breeding of miscellaneous bacteria, have fungi-proofing, effect of insect protected, can be used for the treatment of dermatitis, beriberi, pruritus disease, remarkable to itch stopping and diminish inflammation effect;
Selected citric acid can be in order to prepare buffer solution on chemical technology, adopt citric acid or citric acid salt to make builder, can improve the performance of cleaning product, precipitate metal ion rapidly, prevent that pollutant are re-attached on fabric, make dirt and ash disperse and suspend, improve the performance of surfactant, it is a kind of good intercalating agent, citric acid belongs to the one of fruit acid, Main Function is to accelerate cutin to upgrade, be usually used in emulsion, cream, shampoo, whitening articles for use, aging resistance articles for use, Acne etc., the renewal of cutin contribute to skin in melanic peeling off, the contraction of pore, the dissolving of blackhead etc.,
Selected aloe-emodin is the antibiotic effective ingredient of Radix Et Rhizoma Rhei, it is the chemical substance of a kind of orange acicular crystal (toluene) or khaki crystalline powder, from Aloe, extract, there is anti-tumor activity, antibacterial activity and immunosuppressive action, discharge function, be now widely used as medicine, cosmetic material;
Handwashing liquid of the present invention combines above-mentioned functions composition and organic acid, anti-hard water agent, pure plant perfume, thickening agent, deionized water with rational proportioning; not only can sterilizing; eliminate such as staphylococcus aureus of a series of antibacterial and pathogen; escherichia coli; Salmonella typhi; Pseudomonas aeruginosa; proteus vulgaris etc.; to eliminate the impact on check accuracy test, and abnormal smells from the patient fragrance, skin care effect there is; protection both hands; raw material is easy to get, and preparation technology is simple, makes popularization.
Detailed description of the invention
Below in conjunction with specific embodiment and bacteriostatic test, the present invention is described in more detail.
Embodiment 1:
Formula: the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory, comprises 24 parts of functional components, 1 part of organic acid, 0.1 part of anti-hard water agent, 0.15 part of thickening agent, 0.2 part of pure plant perfume, 40 parts of deionized waters.The weight portion of described functional components is respectively: 22 parts of Fructus Gleditsia extracts, 1.5 parts of plant vinegar liquids, 0.5 part of aloe-emodin; The selected raw material of described Fructus Gleditsia extract is Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, and its ratio is 2: 4: 1; Described plant vinegar liquid is one or more mixture in Bamboo vinegar solution, wood vinegar and CAOSU liquid, and described organic acid is citric acid.
Preparation technology:
First, prepare Fructus Gleditsia extract: take in proportion Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, Fructus Gleditsia fruit and Fructus Gleditsia acupuncture are ground into coarse powder, be placed in boiler together with Folium Gleditsiae, add water to and exceed medical material upper surface 5cm, big fire is boiled to boiling, changing slow fire boiling extracts 2 times, each extraction 1 hour, impurity, merging filtrate are removed in hyperfiltration, be evaporated to relative density and be 0.85 extractum, except color, obtain water white transparency extractum with activated carbon adsorption, be Fructus Gleditsia extract.
Secondly, preparation Fructus Gleditsia handwashing liquid: add the deionized water of formula ratio in container, temperature is controlled at 22 DEG C, add successively again functional components, organic acid, anti-hard water agent, pure plant perfume, limit edged stirs, and mixing speed is controlled at 30r/min, finally adds thickening agent, described thickening agent is preferably Sodium Alginate, after stirring, still aging at 16 DEG C of temperature, after froth breaking to be de-gassed, carry out subpackage, the special Fructus Gleditsia handwashing liquid of Ji get clinical laboratory with handwashing liquid filling machine.
Embodiment 2:
Formula:
The special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory, comprises 32 parts of functional components, 2 parts of organic acid, 0.15 part of anti-hard water agent, 0.25 part of thickening agent, 0.35 part of pure plant perfume, 50 parts of deionized waters.The weight portion of described functional components is respectively: 26 parts of Fructus Gleditsia extracts, 3.5 parts of plant vinegar liquids, 2.0 parts of aloe-emodins; The selected raw material of described Fructus Gleditsia extract is Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, and its ratio is 2: 4: 1; Described plant vinegar liquid is one or more mixture in Bamboo vinegar solution, wood vinegar and CAOSU liquid, and described organic acid is citric acid.
Preparation technology:
First, prepare Fructus Gleditsia extract: take in proportion Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, Fructus Gleditsia fruit and Fructus Gleditsia acupuncture are ground into coarse powder, be placed in boiler together with Folium Gleditsiae, add water to and exceed medical material upper surface 6.5cm, big fire is boiled to boiling, changing slow fire boiling extracts 2 times, each extraction 1.5 hours, impurity, merging filtrate are removed in hyperfiltration, be evaporated to relative density and be 0.905 extractum, except color, obtain water white transparency extractum with activated carbon adsorption, be Fructus Gleditsia extract.
Secondly, preparation Fructus Gleditsia handwashing liquid: add the deionized water of formula ratio in container, temperature is controlled at 25 DEG C, add successively again functional components, organic acid, anti-hard water agent, pure plant perfume, limit edged stirs, and mixing speed is controlled at 40r/min, finally adds thickening agent, described thickening agent is preferably Sodium Alginate, after stirring, still aging at 23 DEG C of temperature, after froth breaking to be de-gassed, carry out subpackage, the special Fructus Gleditsia handwashing liquid of Ji get clinical laboratory with handwashing liquid filling machine.
Embodiment 3:
Formula:
The special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory, comprises 40 parts of functional components, 3 parts of organic acid, 0.2 part of anti-hard water agent, 0.35 part of thickening agent, 0.5 part of pure plant perfume, 60 parts of deionized waters.The weight portion of described functional components is respectively: 30 parts of Fructus Gleditsia extracts, 5.5 parts of plant vinegar liquids, 3.5 parts of aloe-emodins; The selected raw material of described Fructus Gleditsia extract is Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, and its ratio is 2: 4: 1; Described plant vinegar liquid is one or more mixture in Bamboo vinegar solution, wood vinegar and CAOSU liquid, and described organic acid is citric acid.
Preparation technology:
First, prepare Fructus Gleditsia extract: take in proportion Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, Fructus Gleditsia fruit and Fructus Gleditsia acupuncture are ground into coarse powder, be placed in boiler together with Folium Gleditsiae, add water to and exceed medical material upper surface 8cm, big fire is boiled to boiling, changing slow fire boiling extracts 3 times, each extraction 2 hours, impurity, merging filtrate are removed in hyperfiltration, be evaporated to relative density and be 0.96 extractum, except color, obtain water white transparency extractum with activated carbon adsorption, be Fructus Gleditsia extract.
Secondly, preparation Fructus Gleditsia handwashing liquid: add the deionized water of formula ratio in container, temperature is controlled at 28 DEG C, add successively again functional components, organic acid, anti-hard water agent, pure plant perfume, limit edged stirs, and mixing speed is controlled at 50r/min, finally adds thickening agent, described thickening agent is preferably Sodium Alginate, after stirring, still aging at 30 DEG C of temperature, after froth breaking to be de-gassed, carry out subpackage, the special Fructus Gleditsia handwashing liquid of Ji get clinical laboratory with handwashing liquid filling machine.
Bacteriostatic test
1. grouping: the random selection check staff of section and sufferer 200 examples that accept inspection, be divided at random 5 groups, every group of 40 people, 1,2,3 groups is test group, 4,5 groups is matched group, 1,2,3 groups of handwashing liquid that use respectively embodiment 1, embodiment 2, embodiment 3 to prepare, 4 groups use common anti-bacterial hand lotion, and 5 groups use tap water.
2. using method: first rinse both hands with tap water, 1, take handwashing liquid prepared by the present embodiment 1, embodiment 2, embodiment 3 for 2,3 groups, take common anti-bacterial hand lotion in right amount in both hands for the 4th group, evenly wash by rubbing with the hands in hand, especially between finger tip and finger, keep the time of contact of 20 seconds, after washing, rinse out foam with tap water again, natural drying, the 5th group is only rinsed with tap water.
3. antibacterial test: according to Disease Control and Prevention Center (CDC), the method for testing in People's Republic of China's hand disinfection technical specification 2002 that infection control tissue proposes.At 37 DEG C of temperature, test organisms is dust Xi Shi escherichia coli, staphylococcus aureus, bacillus pyocyaneus, and each test organisms content is 107/ml, and be 1 minute time of contact.Requirement by detecting: the minimum microorganism (killing rate > 99.9%) of killing 3 logarithms.Every results averaged.
4. test bit statistics:
Table 1 is to killing bacteria logarithm value
| Killing bacteria logarithm | 1 group | 2 groups | 3 groups | 4 groups | 5 groups |
| Dust Xi Shi escherichia coli | 9 | 8 | 9 | 3 | 0 |
| Staphylococcus aureus | 8 | 9 | 7 | 2 | 0 |
| Bacillus pyocyaneus | 7 | 8 | 9 | 2 | 0 |
Table 2 hand natural bacteria average kill ratio (%)
| Average kill ratio | 1 group | 2 groups | 3 groups | 4 groups | 5 groups |
| 30min | 98.0％ | 97.5％ | 99.8％ | 84.1％ | 0 |
| 90min | 95.3％ | 94.2％ | 95.7％ | 57.2％ | 0 |
| 180min | 92.1％ | 91.6％ | 89.3％ | 32.3％ | 0 |
5. experimental result: as can be seen from the table, handwashing liquid provided by the invention, after 180min, still has good bacterial inactivation rate; Conventional products in matched group 4, its bacteriostasis property is relatively low, and along with the prolongation of time, its fungistatic effect declines very fast.So handwashing liquid of the present invention has the effect of Quick disinfection, and the sterilization persistent period is longer.
Claims (7)
1. the special Fructus Gleditsia handwashing liquid of clinical laboratory, it is characterized in that comprising functional components 24-40 part, organic acid 1-3 part, anti-hard water agent 0.1-0.2 part, thickening agent 0.15-0.35 part, pure plant perfume 0.2-0.5 part, deionized water 40-60 part, described functional components is Fructus Gleditsia extract, plant vinegar liquid, aloe-emodin.
2. the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory as claimed in claim 1, is characterized in that the weight portion of described functional components is respectively: Fructus Gleditsia extract 22-30 part, plant vinegar liquid 1.5-5.5 part, aloe-emodin 0.5-3.5 part.
3. the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory as claimed in claim 2, is characterized in that the described selected raw material of Fructus Gleditsia extract is Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture, and its ratio is 2: 4: 1.
4. the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory as claimed in claim 2, is characterized in that described plant vinegar liquid is one or more mixture in Bamboo vinegar solution, wood vinegar and CAOSU liquid.
5. the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory as claimed in claim 1, is characterized in that described organic acid is citric acid.
6. the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory as claimed in claim 1 or 2, the preparation method that it is characterized in that described Fructus Gleditsia extract is: take Fructus Gleditsia fruit, Folium Gleditsiae, Fructus Gleditsia acupuncture in described ratio, be placed in together boiler, add water to and exceed medical material upper surface 5-8cm, heating decocts extracts 2-3 time, each 1-2 hour that extracts, filter, merging filtrate, with activated carbon adsorption except color, concentrating under reduced pressure obtains extractum, is Fructus Gleditsia extract.
7. the preparation method of the special Fructus Gleditsia handwashing liquid of a kind of clinical laboratory as claimed in claim 1 or 2, it is characterized in that comprising the following steps: the deionized water that adds formula ratio in container, temperature is controlled at 22-28 DEG C, add successively again functional components, organic acid, anti-hard water agent, pure plant perfume, limit edged stirs, and mixing speed is controlled at 30-50r/min, finally adds thickening agent, after stirring, still aging at 16-30 DEG C of temperature; After froth breaking to be de-gassed, the special Fructus Gleditsia handwashing liquid of Ji get clinical laboratory.
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| CN105534748A (en) * | 2015-12-29 | 2016-05-04 | 辛集市远翔环保能源科技有限公司 | Hand sanitizer |
| CN110327837A (en) * | 2019-07-10 | 2019-10-15 | 黄伟玲 | A kind of aroma type shower cream system of processing and processing method and aroma type shower cream |
| CN115400042A (en) * | 2022-09-13 | 2022-11-29 | 广州德谷个人护理用品有限公司 | Gleditsia sinensis composition and application thereof |
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Cited By (4)
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| CN105534748A (en) * | 2015-12-29 | 2016-05-04 | 辛集市远翔环保能源科技有限公司 | Hand sanitizer |
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Application publication date: 20141015 |