CN104435605A - Preparation method of Chinese herbal medicine skin disinfectant - Google Patents
Preparation method of Chinese herbal medicine skin disinfectant Download PDFInfo
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- CN104435605A CN104435605A CN201410700241.7A CN201410700241A CN104435605A CN 104435605 A CN104435605 A CN 104435605A CN 201410700241 A CN201410700241 A CN 201410700241A CN 104435605 A CN104435605 A CN 104435605A
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- 241000411851 herbal medicine Species 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000000645 desinfectant Substances 0.000 title abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000000706 filtrate Substances 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229930006000 Sucrose Natural products 0.000 claims abstract description 15
- 239000005720 sucrose Substances 0.000 claims abstract description 15
- 241001116389 Aloe Species 0.000 claims abstract description 14
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 14
- -1 palmitic acid sucrose ester Chemical class 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 240000002234 Allium sativum Species 0.000 claims abstract description 5
- 235000004611 garlic Nutrition 0.000 claims abstract description 5
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 29
- 230000002421 anti-septic effect Effects 0.000 claims description 22
- 244000178870 Lavandula angustifolia Species 0.000 claims description 13
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 13
- 241000628997 Flos Species 0.000 claims description 12
- 238000004821 distillation Methods 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 239000000052 vinegar Substances 0.000 claims description 5
- 235000021419 vinegar Nutrition 0.000 claims description 5
- 230000035613 defoliation Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 12
- 238000001914 filtration Methods 0.000 abstract description 6
- 238000000227 grinding Methods 0.000 abstract description 6
- 206010040880 Skin irritation Diseases 0.000 abstract description 3
- 230000036556 skin irritation Effects 0.000 abstract description 3
- 231100000475 skin irritation Toxicity 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 4
- 244000124209 Crocus sativus Species 0.000 abstract 2
- 235000015655 Crocus sativus Nutrition 0.000 abstract 2
- 239000012153 distilled water Substances 0.000 abstract 2
- 235000013974 saffron Nutrition 0.000 abstract 2
- 239000004248 saffron Substances 0.000 abstract 2
- 238000005303 weighing Methods 0.000 abstract 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000013717 Houttuynia Nutrition 0.000 abstract 1
- 240000000691 Houttuynia cordata Species 0.000 abstract 1
- 235000021314 Palmitic acid Nutrition 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000013011 mating Effects 0.000 abstract 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 abstract 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 29
- 230000001954 sterilising effect Effects 0.000 description 14
- 230000000844 anti-bacterial effect Effects 0.000 description 13
- 241000894006 Bacteria Species 0.000 description 10
- 210000004247 hand Anatomy 0.000 description 9
- 239000000344 soap Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 206010011409 Cross infection Diseases 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- 230000003559 chemosterilizing effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000003206 sterilizing agent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 208000035742 Air-borne transmission Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000193755 Bacillus cereus Species 0.000 description 1
- 241000194107 Bacillus megaterium Species 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 241001312524 Streptococcus viridans Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000005557 airborne transmission Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical class OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000009365 direct transmission Effects 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000009349 indirect transmission Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 150000003463 sulfur Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention provides a preparation method of a Chinese herbal medicine skin disinfectant. The method comprises the following steps: weighing 15 parts of scutellarta root, 15 parts of honeysuckle, 8 parts of aloe, 4 parts of saffron, and 6 parts of saffron, adding distilled water with the amount being 6 to 8 times of that of the crude drugs to boil the crude drugs for 20 to 30min, filtering, adding distilled water with the amount being 5 to 6 times of that of the crude drugs to boil the crude drugs for 15 to 20 min again, filtering, combining filtrate, adding activated carbon to perform decoloration and filtering, concentrating the filtrate to be 0.8 times of the original volume of the filtrate, filtering, then weighing 15 parts of cordate houttuynia, and 8 parts of garlic, adding 60 to 70 percent ethyl alcohol, performing grinding and filtering, adding the filtrate, 2 parts of hibitane, 2 parts of glycerin, and 7 parts of palmitic acid sucrose ester into the concentrated solution, stirring and dissolving, and then obtaining the skin disinfectant. The Chinese herbal medicine skin disinfectant prepared through the method does not have pungent smell, is low in toxicity, can not cause skin irritation, and improves the sterilization and disinfection effects through the mating reaction between Chinese herbal medicine and hibitane.
Description
Technical field
The present invention relates to disinfection technology field, particularly a kind of preparation method of Chinese herbal medicine skin antiseptic.
Background technology
Skin parasitic various microorganism, comprise various bacterial propagule, fungus, pathogenic bacteria etc., especially hand skin, because the chance of its contact article is more, the kind of contaminating microorganisms and quantity are also maximum, particularly the germ contamination of medical personnel's hand is even more serious, if sterilization thoroughly will not give oneself, patient and household bring disease risk, massive epidemiology survey data shows, the normally direct or indirect transmission by hand of hospital infection, this approach has more danger than air-borne transmission, therefore wash one's hands in institute to have become and reduce the most feasible most important measure of hospital infection.Investigation finds the general hand strap bacterium of medical personnel 104, suction sputum hand strap bacterium 108, hand strap of changing dressings bacterium 108 ~ 9, end bedpan hand strap bacterium 1010 ~ 11.Hands before and after making the rounds of the wards to doctor collective is monitored, and finds that the hands microbiological contamination of doctor is serious, minimum 10.8 cfu/cm2 of bacteria containing amount, the most nearly 68.2 cfu/cm2.General nursery work, as fought for patient's rapid pulse, assisting patients changes position, for patient makes the bed, operator on hand polluted bacteria number is 103 ~ 105 cfu/ handss, and defensive position of changing dressings polluted bacteria number can reach 10 cfu/ handss.Before carrying out operation, medical personnel's hand amount of bacteria mean height of nearly 50% goes out 9.5 times of standard, and content of molds reaches as high as 1 009 cfu/cm2.When being busy with one's work, hand antibacterial is multiplied, and itself and hand Carriage are under normal circumstances compared, average bacterium amount exceeds 1 times, and soprano can reach 5 600 cfu/cm2.By checking the finger of 100 nurses, detect 6 kinds, antibacterial altogether, wherein staphylococcus aureus accounts for 36%, and staphylococcus epidermidis accounts for 40%, and proteus mirabilis accounts for 8%, and Streptococcus viridans and bacillus megaterium account for 4% respectively, and Bacillus cereus accounts for 8%.Main based on staphylococcus aureus and staphylococcus epidermidis, account for 76% of sum.Obviously, the hands contact patient body of medical personnel, Excreta, articles for use are more, and content of molds and strain are also more, and all carry disease germs in any position of hands.Sterilization treatment cannot be carried out after hand contamination antibacterial, effective sterilizing methods can not be used for skin, and flora is attached to skin itself and makes a farfetched comparison and to be more difficult to remove and kill on lifeless object, therefore, concerning medical personnel, regular washing one's hands is the important means preventing foreign bacteria field planting and propagation.Effectively can reduce NIR.
Traditional hand skin sterilization has two kinds of methods: soap flowing is washed one's hands and chemosterilant sterilization.Soap sterilization is widely used, but the part that comes with some shortcomings, as more weak in boric acid class disinfectant soap disinfection force, to virus, parasite weak effect; Phenols disinfectant soap is comparatively strong to skin irritation, and to skin sensitivity and littlely have the people of wound not too applicable, and the effect of killing fungus is poor; Sulfur class disinfectant soap shortcoming suppresses sebum secretion effect comparatively strong, uses rear skin may become drier.What chemosterilant was conventional has hibitane, iodine, ethanol, glutaraldehyde etc., and they have respective pluses and minuses respectively, can not disinfection comprehensively and effectively.And these disinfectant liquid for skin are mostly synthetics, as Iodic agent, alcohol disinfectant etc., the general poor stability of these materials, large to human body zest, life-time service has certain potential hazard to human body.
One section of publication number is the preparation method disclosing a kind of composite type medical disinfectant in the patent document of CN1182533, it is by glutaraldehyde, Radix Glycyrrhizae derivant, non-ionic surface active agent, essence, deionized water forms, this disinfectant can be directly used in the washing of various trauma patient, sterilization, simultaneously to the sterilization of medical worker's operation consent, the sterilization of various medical apparatus and instruments, the sterilization of hygienic article all has function and the cleaning function of very strong killing pathogenic bacteria, simultaneously main is have promotion wound, the effect of healing, this disinfectant chemical stabilization, safety is high, without any side effects to human body skin.Glutaraldehyde is wherein the colourless transparent oil liquid with penetrating odor, is dissolved in hot water, has strong impulse effect to eyes, skin and mucosa, although bactericidal effect is good, is not suitable for skin degerming.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of Chinese herbal medicine skin antiseptic, this skin antiseptic effectively sterilize comprehensively, while stain removal bactericidal, little to skin irritation, use rear skin moist, be also applicable to skin sensitivity and littlely have wound people to use.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions.
A preparation method for Chinese herbal medicine skin antiseptic, prepares: (1) takes Radix Scutellariae 15 parts, Herba Houttuyniae 15 parts, Flos Lonicerae 15 parts, 8 parts, Bulbus Allii, Aloe 8 parts, lavandula angustifolia 4 parts, Stigma Croci 6 parts, hibitane 2 parts, glycerol 2 parts, Palmic acid sucrose ester 7 parts in the steps below;
(2) ethanol Herba Houttuyniae weighed up in step (1), Bulbus Allii being added appropriate 60%-70% fully grinds, and filter, filtrate is for subsequent use;
(3) Radix Scutellariae weighed up in step (1), Flos Lonicerae, Aloe, lavandula angustifolia, Stigma Croci are added the distillation decocting in water 20-30min of 6-8 times amount, filter, medicinal residues add 5-6 times amount distillation decocting in water 15-20min again, filter, merge filtrate, add active carbon, stir decolouring;
(4) the filtrate heating after decolouring is concentrated into 0.8 times of original volume, cooling, then adds the filtrate in hibitane, glycerol, Palmic acid sucrose ester and the step (2) weighed up in step (1), stirs and makes it fully dissolve to obtain skin antiseptic.
Described Bulbus Allii is only head purple garlic.
Described Herba Houttuyniae is fresh defoliation Herba Houttuyniae.
Further, in Bulbus Allii and Herba Houttuyniae process of lapping, 1-2 part white vinegar is added.
Further, be that concentrated solution in step (4) is cooled to 35-45 DEG C.
Further, be that the ethanol Herba Houttuyniae weighed up, Bulbus Allii being added the 60%-70% of 1-2 times amount fully grinds.
Beneficial effect:
1, the skin antiseptic good anti-bacterial effect adopting the inventive method to prepare, preparation method is simple, the present invention adopt have sterilization Chinese herbal medicine and hibitane compatibility as disinfectant, the disinfectant decreasing chemical composition must use, extracts of Chinese herbal medicine gentleness does not stimulate, and share with hibitane compatibility, bactericidal effect is good, and antibacterial range is wide.Have effect of moisturizing and anti-inflammation containing Aloe in the present invention, contribute to the healing of skin wound, lavandula angustifolia extracting solution has cleaning skin, anti-inflammatory efficacy simultaneously, can prevention infection and inflammation effect; , light anaesthesia can also be played and do in order to detumescence pain; Palmic acid sucrose ester in the present invention can promote the dissolubility of medicinal herb components and hibitane and improve the effect of bactericidal effect, is be made up of sucrose and oils and fats, tasteless, nontoxic, and energy biodegradation, not chafe, do not pollute the environment.Adopt Bulbus Allii and Herba Houttuyniae to add the filtrate of ethanol grinding, without the need to other composition heating extraction, well maintain the effectiveness of its sterilization component.
2, the present invention adopts only head purple garlic, containing more sterilization component, bactericidal effect is good, and the present invention has collaborative effect in the bactericidal action adding white vinegar and Bulbus Allii, strengthens bactericidal effect, add in the process of lapping of Bulbus Allii and Herba Houttuyniae, a small amount of ethanol and white vinegar can react production ethyl acetate, have fragranced, can increase the fragrance of disinfectant solution like this, there is the effect covering the garlicky and Herba Houttuyniae fishy smell of Bulbus Allii, without the need to adding essence.Adopt the Herba Houttuyniae grinding of defoliation, lapping liquid can use after filtering, without the need to decolouring.
Bulbus Allii and Herba Houttuyniae is adopted to add the filtrate of ethanol grinding, without the need to other composition heating extraction, well maintain the effectiveness of its sterilization component, after being cooled to 35-45 DEG C after extracts of Chinese herbal medicine is concentrated, add other compositions, particularly can increase the dissolubility of hibitane, ensure bactericidal effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described.
Embodiment 1
A preparation method for Chinese herbal medicine skin antiseptic, prepares: (1) takes Radix Scutellariae 15 parts, Herba Houttuyniae 15 parts, Flos Lonicerae 15 parts, 8 parts, Bulbus Allii, Aloe 8 parts, lavandula angustifolia 4 parts, Stigma Croci 6 parts, hibitane 2 parts, glycerol 2 parts, Palmic acid sucrose ester 7 parts in the steps below;
(2) ethanol Herba Houttuyniae weighed up in step (1), Bulbus Allii being added appropriate 60% fully grinds, and filter, filtrate is for subsequent use;
(3) Radix Scutellariae weighed up in step (1), Flos Lonicerae, Aloe, lavandula angustifolia, Stigma Croci are added the distillation decocting in water 20min of 6 times amount, filter, medicinal residues add 5-6 times amount distillation decocting in water 15min again, filter, merge filtrate, add active carbon, stir decolouring;
(4) the filtrate heating after decolouring is concentrated into 0.8 times of original volume, cooling, then adds the filtrate in hibitane, glycerol, Palmic acid sucrose ester and the step (2) weighed up in step (1), stirs and makes it fully dissolve to obtain skin antiseptic.
Embodiment 2
A preparation method for Chinese herbal medicine skin antiseptic, prepares: (1) takes Radix Scutellariae 15 parts, Herba Houttuyniae 15 parts, Flos Lonicerae 15 parts, 8 parts, Bulbus Allii, Aloe 8 parts, lavandula angustifolia 4 parts, Stigma Croci 6 parts, hibitane 2 parts, glycerol 2 parts, Palmic acid sucrose ester 7 parts in the steps below;
(2) ethanol Herba Houttuyniae weighed up in step (1), Bulbus Allii being added appropriate 65% fully grinds, and filter, filtrate is for subsequent use;
(3) Radix Scutellariae weighed up in step (1), Flos Lonicerae, Aloe, lavandula angustifolia, Stigma Croci are added the distillation decocting in water 25min of 7 times amount, filter, medicinal residues add 5-6 times amount distillation decocting in water 17min again, filter, merge filtrate, add active carbon, stir decolouring;
(4) the filtrate heating after decolouring is concentrated into 0.8 times of original volume, cooling, then adds the filtrate in hibitane, glycerol, Palmic acid sucrose ester and the step (2) weighed up in step (1), stirs and makes it fully dissolve to obtain skin antiseptic.
Described Bulbus Allii is only head purple garlic.Described Herba Houttuyniae is fresh defoliation Herba Houttuyniae.
Embodiment 3
A preparation method for Chinese herbal medicine skin antiseptic, prepares: (1) takes Radix Scutellariae 15 parts, Herba Houttuyniae 15 parts, Flos Lonicerae 15 parts, 8 parts, Bulbus Allii, Aloe 8 parts, lavandula angustifolia 4 parts, Stigma Croci 6 parts, hibitane 2 parts, glycerol 2 parts, Palmic acid sucrose ester 7 parts in the steps below;
(2) ethanol Herba Houttuyniae weighed up in step (1), Bulbus Allii being added appropriate 70% fully grinds, and filter, filtrate is for subsequent use;
(3) Radix Scutellariae weighed up in step (1), Flos Lonicerae, Aloe, lavandula angustifolia, Stigma Croci are added the distillation decocting in water 30min of 8 times amount, filter, medicinal residues add 5-6 times amount distillation decocting in water 20min again, filter, merge filtrate, add active carbon, stir decolouring;
(4) the filtrate heating after decolouring is concentrated into 0.8 times of original volume, cooling, then adds the filtrate in hibitane, glycerol, Palmic acid sucrose ester and the step (2) weighed up in step (1), stirs and makes it fully dissolve to obtain skin antiseptic.Wherein in Bulbus Allii and Herba Houttuyniae process of lapping, add 1-2 part white vinegar.
Embodiment 4
A preparation method for Chinese herbal medicine skin antiseptic, prepares: (1) takes Radix Scutellariae 15 parts, Herba Houttuyniae 15 parts, Flos Lonicerae 15 parts, 8 parts, Bulbus Allii, Aloe 8 parts, lavandula angustifolia 4 parts, Stigma Croci 6 parts, hibitane 2 parts, glycerol 2 parts, Palmic acid sucrose ester 7 parts in the steps below;
(2) ethanol Herba Houttuyniae weighed up in step (1), Bulbus Allii being added appropriate 65% fully grinds, and filter, filtrate is for subsequent use;
(3) Radix Scutellariae weighed up in step (1), Flos Lonicerae, Aloe, lavandula angustifolia, Stigma Croci are added the distillation decocting in water 25min of 7 times amount, filter, medicinal residues add 5-6 times amount distillation decocting in water 16min again, filter, merge filtrate, add active carbon, stir decolouring;
(4) the filtrate heating after decolouring is concentrated into 0.8 times of original volume, cooling, then adds the filtrate in hibitane, glycerol, Palmic acid sucrose ester and the step (2) weighed up in step (1), stirs and makes it fully dissolve to obtain skin antiseptic.That concentrated solution in step (4) is cooled to 35-45 DEG C.Further, be add the ethanol grinding of 65% of 1-2 times amount as well by when the Herba Houttuyniae weighed up, Bulbus Allii grinding.
Claims (6)
1. a preparation method for Chinese herbal medicine skin antiseptic, is characterized in that: prepare in the steps below: (1) takes Radix Scutellariae 15 parts, Herba Houttuyniae 15 parts, Flos Lonicerae 15 parts, 8 parts, Bulbus Allii, Aloe 8 parts, lavandula angustifolia 4 parts, Stigma Croci 6 parts, hibitane 2 parts, glycerol 2 parts, Palmic acid sucrose ester 7 parts;
(2) ethanol Herba Houttuyniae weighed up in step (1), Bulbus Allii being added appropriate 60%-70% fully grinds, and filter, filtrate is for subsequent use;
(3) Radix Scutellariae weighed up in step (1), Flos Lonicerae, Aloe, lavandula angustifolia, Stigma Croci are added the distillation decocting in water 20-30min of 6-8 times amount, filter, medicinal residues add 5-6 times amount distillation decocting in water 15-20min again, filter, merge filtrate, add active carbon, stir decolouring;
(4) the filtrate heating after decolouring is concentrated into 0.8 times of original volume, cooling, then adds the filtrate in hibitane, glycerol, Palmic acid sucrose ester and the step (2) weighed up in step (1), stirs and makes it fully dissolve to obtain skin antiseptic.
2. the preparation method of a kind of Chinese herbal medicine skin antiseptic according to claim 1, is characterized in that: described Bulbus Allii is only head purple garlic.
3. the preparation method of a kind of Chinese herbal medicine skin antiseptic according to claim 1, is characterized in that: described Herba Houttuyniae is fresh defoliation Herba Houttuyniae.
4. the preparation method of a kind of Chinese herbal medicine skin antiseptic according to claim 1, is characterized in that: in Bulbus Allii and Herba Houttuyniae process of lapping, add 1-2 part white vinegar.
5. the preparation method of a kind of Chinese herbal medicine skin antiseptic according to claim 1, is characterized in that: be that concentrated solution in step (4) is cooled to 35-45 DEG C.
6. the preparation method of a kind of Chinese herbal medicine skin antiseptic according to claim 1, is characterized in that: be that the ethanol Herba Houttuyniae weighed up, Bulbus Allii being added the 60%-70% of 1-2 times amount fully grinds.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108553571A (en) * | 2018-06-19 | 2018-09-21 | 山东柯尔杰卫生科技有限公司 | One kind is based on pure plant extraction type skin antiseptic and preparation method thereof |
| CN109125180A (en) * | 2018-10-15 | 2019-01-04 | 山东麦德森医疗科技有限公司 | A kind of preparation and its detection test method of Traditional Chinese medicinal hand lotion |
| CN113304205A (en) * | 2021-04-28 | 2021-08-27 | 徐莉英 | Preparation process of low-temperature long-acting disinfectant for wounds |
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| CN108553571A (en) * | 2018-06-19 | 2018-09-21 | 山东柯尔杰卫生科技有限公司 | One kind is based on pure plant extraction type skin antiseptic and preparation method thereof |
| CN109125180A (en) * | 2018-10-15 | 2019-01-04 | 山东麦德森医疗科技有限公司 | A kind of preparation and its detection test method of Traditional Chinese medicinal hand lotion |
| CN113304205A (en) * | 2021-04-28 | 2021-08-27 | 徐莉英 | Preparation process of low-temperature long-acting disinfectant for wounds |
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