CN113304205A - Preparation process of low-temperature long-acting disinfectant for wounds - Google Patents

Preparation process of low-temperature long-acting disinfectant for wounds Download PDF

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CN113304205A
CN113304205A CN202110466977.2A CN202110466977A CN113304205A CN 113304205 A CN113304205 A CN 113304205A CN 202110466977 A CN202110466977 A CN 202110466977A CN 113304205 A CN113304205 A CN 113304205A
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low
preparation process
temperature
parts
disinfectant
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徐莉英
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a preparation process of a low-temperature long-acting disinfectant for wounds, which belongs to the technical field of disinfectant, can improve the formula of the disinfectant, uses mild traditional Chinese medicine raw materials and has various chemical components for promoting blood circulation and removing blood stasis, clearing heat and releasing toxin, diminishing inflammation and relieving pain, can inhibit the growth of harmful bacteria around the wounds, kill most of the harmful bacteria, avoid wound infection, simultaneously realize pus discharge and granulation promotion, promote the healing of the wounds and shorten the healing time of the wounds, simultaneously, the doped low-temperature capsule can be lightly crushed when in use, can trigger the double actions of compression and refrigeration by absorbing the water contained in the disinfectant, on one hand, cover the wounds, reduce the loss of the disinfectant and simultaneously reduce the contact area with the outside, on the other hand, the low-temperature achieves the effect of slight anesthesia and reduces the pain brought by the disinfection of the wounds, and the volatilization of the disinfectant is reduced, and the long-acting disinfection effect is realized.

Description

Preparation process of low-temperature long-acting disinfectant for wounds
Technical Field
The invention relates to the technical field of disinfectant, in particular to a preparation process of a low-temperature long-acting disinfectant for wounds.
Background
The disinfectant is used for killing pathogenic microorganisms on a transmission medium, so that the requirement of harmlessness is met, the pathogenic microorganisms are killed out of a human body, the transmission path of infectious diseases is cut off, and the purpose of controlling the infectious diseases is achieved.
The disinfectant can be divided into a sterilizing agent, a high-efficiency disinfectant, a middle-efficiency disinfectant and a low-efficiency disinfectant according to the action level. The sterilizing agent can kill all microorganisms to meet the sterilizing requirement, and comprises formaldehyde, glutaraldehyde, ethylene oxide, peracetic acid, hydrogen peroxide, chlorine dioxide, chlorine, copper sulfate, quicklime, ethanol and the like.
The high-efficiency disinfectant can kill all bacteria propagules (including mycobacteria), viruses, fungi, spores thereof and the like, has a certain killing effect on bacterial spores, meets the requirement of high-level disinfection, and comprises chlorine-containing disinfectant, ozone, methyl hydantoin compounds, double-chain quaternary ammonium salt and the like. The intermediate disinfectant can only kill microbes such as mycobacteria, fungi, viruses, bacterial propagules and the like, meets the disinfection requirement and comprises iodine-containing disinfectant, alcohol disinfectant, phenol disinfectant and the like. The low-efficiency disinfectant can only kill bacteria propagules and lipophilic viruses to meet the requirements of the disinfectant, and comprises quaternary ammonium salt disinfectants such as benzalkonium bromide and the like, biguanide disinfectants such as chlorhexidine (chlorhexidine) and the like, metal ion disinfectants such as mercury, silver, copper and the like and Chinese herbal medicine disinfectants. The disinfectant is a preparation for killing pathogenic microorganisms on a transmission medium to ensure that the pathogenic microorganisms meet the harmless requirement, is different from antibiotics, and has the main function of killing the pathogenic microorganisms outside a human body in disease prevention, cutting off the transmission path of infectious diseases and achieving the purpose of controlling the infectious diseases.
Wounds can be defined as skin defects caused by mechanical, electrical, thermal, chemical, etc. factors or due to physiological allergies, wound infection remains a fearful and expensive complication, and therefore, reasonable and timely wound debridement and disinfection are of paramount importance. However, the wound disinfection solution on the market at present only has basic wound debridement or disinfection effects, is not accompanied by other effects, has short disinfection effect, and is easy to cause pain and secondary infection.
Disclosure of Invention
1. Technical problem to be solved
Aiming at the problems in the prior art, the invention aims to provide a preparation process of a low-temperature long-acting disinfectant for wounds, which can improve the formula of the disinfectant, uses mild traditional Chinese medicine raw materials and has various chemical components for promoting blood circulation, removing blood stasis, clearing away heat and toxic materials, diminishing inflammation and relieving pain, can inhibit the growth of harmful bacteria around the wounds, kill most of the harmful bacteria, avoid wound infection, simultaneously realize pus discharge and granulation, promote wound healing and shorten the time of wound healing, simultaneously, the doped low-temperature capsule is lightly crushed when in use, can trigger double actions of compression and refrigeration by absorbing the water contained in the disinfectant, on one hand, cover the wounds, reduce the contact area with the outside while reducing the loss of the disinfectant, on the other hand, achieve the effect of slight anesthesia at low temperature and reduce the pain caused by wound disinfection, and the volatilization of the disinfectant is reduced, and the long-acting disinfection effect is realized.
2. Technical scheme
In order to solve the above problems, the present invention adopts the following technical solutions.
A preparation process of a low-temperature long-acting disinfectant for wounds comprises the following steps:
s1, cleaning 4-6 parts of scutellaria baicalensis, 3-5 parts of wild chrysanthemum, 8-10 parts of honeysuckle, 10-14 parts of angelica, 3-7 parts of fructus cnidii, 4-8 parts of humifuse euphorbia herb, 4-8 parts of saffron crocus and 5-7 parts of corydalis edulis according to parts by weight, crushing and grinding, treating by a 100-mesh and 200-mesh sieve, and mixing and stirring the raw materials uniformly to obtain mixed powder;
s2, uniformly stirring and mixing 10-15 parts of water and the mixed powder, decocting the mixture for 20-40min by slow fire, then continuously decocting for 20-30min when the water temperature is raised to 75-90 ℃, and continuously stirring the mixture during decoction;
s3, filtering after decoction, discarding filter residues, reserving filtrate, and decoloring the filtrate;
s4, adding 15-20 parts of medical alcohol, 1-10 parts of glycerol and 2-6 parts of dispersing agent into the decolored filtrate, and carrying out ultrasonic stirring and mixing while heating in a water bath to prepare a solution;
and S5, uniformly putting a proper amount of low-temperature capsules into the solution in an oxygen-free environment, and then sealing, packaging and warehousing.
Further, the water in step S2 is one of water for injection or sterile water.
Further, the medical alcohol concentration in step S4 is 80%, and the dispersant is one or more of sodium tetradecyl benzenesulfonate, polyethylene glycol, sodium dodecylbenzenesulfonate, and ammonium sulfate.
Further, the water bath heating temperature in the step S4 is 50-70 ℃.
Further, the number of the low-temperature capsules in the step S5 is 1/3 ml-5 ml.
Further, the low temperature capsule in step S5 includes an outer drum coating, the inner end of the outer drum coating is connected with a pair of symmetrically distributed shape control wires, the inner end of the shape control wires is connected with a matched shaping medium layer, the center of the inner end of the outer drum coating is also connected with a stretching middle layer, the center of the stretching middle layer is connected with a low temperature soluble tablet in an embedding manner, the inner end of the outer drum coating is also connected with a pair of trigger blocks corresponding to the low temperature soluble tablet, the trigger blocks are connected with the outer end of the shaping medium layer, the outer drum coating is supported by the shape control wires in a normal state and is in a drum coating, and is separated from the liquid component of the disinfectant, the shaping medium layer is brittle-cracked under artificial pressure, then the shape control wires force the outer drum coating to be flattened and compressed, on one hand, the increase of the contact area with the wound is realized, and on the other hand, the trigger blocks can be contacted with the low temperature soluble tablet after the shape control wires lose the blocking of the shaping medium layer, therefore, the water in the disinfectant is conveyed to the low-temperature dissolving piece, and the refrigeration action of the low-temperature dissolving piece is triggered.
Furthermore, the trigger block comprises a force transmission block, a water absorption end and a plurality of water guide fibers, the force transmission block is connected between the shaping medium layer and the outer drum coating, the water absorption end is connected to one end, close to the shaping medium layer, of the force transmission block in an embedded mode, the water guide fibers are evenly connected to the water absorption end, the water guide fibers penetrate through the outer drum coating and extend to the outer side, the water guide fibers can convey water in the disinfectant to the water absorption end, the shaping medium layer is isolated and blocked in a normal state, and the water absorption end can be in contact with the low-temperature soluble piece under the action of compression only under the condition of crushing, so that the dissolving and refrigerating of the low-temperature soluble piece are achieved.
Furthermore, the outer drum coating is made of a flexible film material, the shape control wire is made of an elastic material and elastically deforms in the direction away from the low-temperature soluble tablet, the shape control wire firstly forces the outer drum coating to bulge under the supporting action of the shaping medium layer, and the shape control wire recovers the shape after the shaping medium layer is cracked, so that the outer drum coating is driven to be paved and compressed.
Furthermore, the stretching middle layer is made of elastic materials and is of a net structure, the low-temperature soluble piece is made of saltpeter, the stretching middle layer can meet the requirement for flattening and compressing the outer drum coating, the low-temperature soluble piece is always kept at the central position and is combined with the trigger block, meanwhile, after the stretching middle layer is stretched, the mesh can accommodate the cracked setting medium layer, the outer drum coating can be guaranteed to be fully flattened, and the trigger block can be smoothly contacted with the low-temperature soluble piece.
Furthermore, the force transfer block is made of a hard material with hardness higher than that of the shaping medium layer, the shaping medium layer is made of a brittle heat conduction material, after the low-temperature capsule is slightly pressed, the force transfer block transfers the pressure to the shaping medium layer, and the shaping medium layer can be broken and does not support the shape of an outer drum coating, so that two actions of leveling and refrigeration are triggered.
3. Advantageous effects
Compared with the prior art, the invention has the advantages that:
(1) the scheme can be improved by a disinfectant formula, mild traditional Chinese medicine raw materials are adopted, the disinfectant has various chemical components for promoting blood circulation to remove blood stasis, clearing heat and detoxifying, diminishing inflammation and relieving pain, the growth of harmful bacteria around a wound can be inhibited, most of the harmful bacteria are killed, pus discharge and granulation can be realized while wound infection is avoided, the healing of the wound is promoted, the time for wound healing is shortened, and meanwhile, the doped low-temperature capsule is lightly crushed when in use, so that the double actions of compression and refrigeration can be triggered by absorbing the moisture contained in the disinfectant, on one hand, the wound is covered, the contact area with the outside is reduced while the loss of the disinfectant is reduced, on the other hand, the effect of slight anesthesia is achieved at low temperature, the pain caused by disinfection at the wound is reduced, the volatilization of the disinfectant is reduced, and the long-acting disinfection effect is realized.
(2) The low-temperature capsule comprises an outer drum coating, wherein the inner end of the outer drum coating is connected with a pair of symmetrically distributed shape control wires, the inner end of each shape control wire is connected with a matched shaping interlayer, the center of the inner end of the outer drum coating is also connected with a stretching middle layer, the center of the stretching middle layer is connected with a low-temperature dissolving tablet in an embedding manner, the inner end of the outer drum coating is also connected with a pair of trigger blocks corresponding to the low-temperature dissolving tablets, the trigger blocks are connected with the outer end of the shaping interlayer, the outer drum coating is supported by the shape control wires to be in a drum coating in a normal state and is separated from the liquid components of disinfectant, the shaping interlayer can be cracked under artificial pressure, then the shape control wires force the outer drum coating to be flattened and compressed, on one hand, the contact area with a wound is increased, and isolation protection is realized, on the other hand, the trigger blocks can be contacted with the low-temperature dissolving tablets after the blockage of the shaping interlayer is lost, so that the moisture in the disinfectant is conveyed to the low-temperature dissolving tablets, further triggering the refrigeration action of the low-temperature melting piece.
(3) The trigger block comprises a force transmission block, a water absorption end and a plurality of water guide fibers, the force transmission block is connected between the shaping medium layer and the outer drum coating, the water absorption end is connected to one end, close to the shaping medium layer, of the force transmission block in an embedded mode, the water guide fibers are evenly connected to the water absorption end, the water guide fibers penetrate through the outer drum coating and extend to the outer side, the water guide fibers can convey water in disinfectant to the water absorption medium layer, the shaping medium layer is isolated and blocked in a normal state, the water absorption end can be in contact with the low-temperature solvent under the action of compression only under the condition of crushing, and therefore the dissolving refrigeration of the low-temperature solvent is achieved.
(4) The outer drum coating is made of flexible film material, the shape control wire is made of elastic material and deforms elastically in the direction far away from the low-temperature soluble tablet, the shape control wire forces the outer drum coating to bulge under the supporting action of the setting medium layer, and the shape control wire recovers the shape after the setting medium layer is cracked, so that the outer drum coating is driven to be spread and compressed.
(5) The stretching middle layer is made of elastic materials and is of a net structure, the low-temperature soluble piece is made of saltpeter, the stretching middle layer can meet the requirement for flattening compression of the outer drum coating, the low-temperature soluble piece is always kept in the central position and is combined with the trigger block, meanwhile, after the stretching middle layer is stretched, the mesh can contain the cracked setting medium layer, the outer drum coating can be fully flattened, and the trigger block can smoothly contact with the low-temperature soluble piece.
(6) The force transfer block is made of a hard material with hardness higher than that of the shaping medium layer, the shaping medium layer is made of a brittle heat conduction material, after the low-temperature capsule is slightly pressed, the force transfer block transfers the pressure to the shaping medium layer, and the shaping medium layer can be broken and does not support the shape of an outer drum coating, so that two actions of paving and refrigerating are triggered.
Drawings
FIG. 1 is a schematic flow diagram of the present invention;
FIG. 2 is a schematic structural view of the low-temperature capsule of the present invention in a normal state;
FIG. 3 is a schematic view of the structure at A in FIG. 2;
FIG. 4 is a schematic structural view of a tensile middle layer of the present invention;
FIG. 5 is a schematic view of the structure of the low-temperature capsule of the present invention in a crushed state.
The reference numbers in the figures illustrate:
1 outer drum coating, 2 shape control wires, 3 shaping interlayer, 4 stretching middle layer, 5 low temperature dissolving sheet, 6 trigger block, 61 force transmission block, 62 water absorption end and 63 water guide fiber.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top/bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "sleeved/connected," "connected," and the like are to be construed broadly, e.g., "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1:
referring to fig. 1, a process for preparing a low-temperature long-acting disinfectant for wounds includes the following steps:
s1, cleaning 4 parts of scutellaria baicalensis, 3 parts of wild chrysanthemum, 8 parts of honeysuckle, 10 parts of angelica sinensis, 3 parts of fructus cnidii, 4 parts of humifuse euphorbia herb, 4 parts of saffron crocus and 5 parts of corydalis edulis according to parts by weight, crushing and grinding, then carrying out 100-mesh sieve treatment, and mixing and stirring the raw materials uniformly to obtain mixed powder;
s2, uniformly stirring and mixing 10 parts of water and the mixed powder, decocting the mixture for 20min by slow fire, then heating the water to 75 ℃, continuing to decoct for 20min, and continuously stirring the decoction;
s3, filtering after decoction, discarding filter residues, reserving filtrate, and decoloring the filtrate;
s4, adding 15 parts of medical alcohol, 1 part of glycerol and 2 parts of dispersing agent into the decolored filtrate, and carrying out ultrasonic stirring and mixing while heating in a water bath to prepare a solution;
and S5, uniformly putting a proper amount of low-temperature capsules into the solution in an oxygen-free environment, and then sealing, packaging and warehousing.
The water in step S2 is one of water for injection or sterile water.
In step S4, the medical alcohol concentration is 80%, and the dispersant is one or more of sodium tetradecyl benzenesulfonate, polyethylene glycol, sodium dodecyl benzenesulfonate, and ammonium sulfate.
The water bath heating temperature in step S4 is 50-70 ℃.
The number of the low-temperature capsules in the step S5 is 1/3 ml-5 ml.
Referring to fig. 2, the low temperature capsule in step S5 includes an outer drum coating 1, the inner end of the outer drum coating 1 is connected with a pair of symmetrically distributed shape control wires 2, the inner end of the shape control wires 2 is connected with a matching shaping medium layer 3, the center of the inner end of the outer drum coating 1 is also connected with a stretching middle layer 4, the center of the stretching middle layer 4 is connected with a low temperature soluble tablet 5 in an embedding manner, the inner end of the outer drum coating 1 is also connected with a pair of trigger blocks 6 corresponding to the low temperature soluble tablet 5, and the trigger blocks 6 are connected with the outer end of the shaping medium layer 3, the outer drum coating 1 is supported by the shape control wires 2 in a normal state and is in a drum, and is separated from the disinfectant liquid component, the shaping medium layer 3 is brittle under artificial pressure, then the shape control wires 2 force the outer drum coating 1 to be spread and compressed, on one hand, the increase of the contact area with the wound and further isolation protection is realized, on the other hand, the trigger blocks 6 can be in contact with the low temperature soluble tablet 5 after the shaping medium layer 3 is lost, therefore, the water in the disinfectant is conveyed to the low-temperature dissolving piece 5, and the refrigeration action of the low-temperature dissolving piece 5 is triggered.
Referring to fig. 4, the trigger block 6 includes a force transfer block 61, a water absorbing end 62 and a plurality of water guiding fibers 63, the water absorbing end 62 and the water guiding fibers 63 are made of water absorbing materials, the force transfer block 61 is connected between the shaping interlayer 3 and the outer drum coating 1, the water absorbing end 62 is connected to one end of the force transfer block 61 close to the shaping interlayer 3 in an embedded manner, the water guiding fibers 63 are uniformly connected to the water absorbing end 62, the water guiding fibers 63 penetrate through the outer drum coating 1 and extend to the outside, the water guiding fibers 63 can convey water in the disinfectant to the water absorbing end 62, but the shaping interlayer 3 is isolated and blocked in a normal state, and the water absorbing end 62 can be in contact with the low temperature soluble tablet 5 under the action of compression only under the condition of crushing, so as to achieve the dissolution and refrigeration of the low temperature soluble tablet 5.
The outer drum coating 1 is made of flexible film materials, the shape control wire 2 is made of elastic materials, the shape control wire 2 is elastically deformed in the direction far away from the low-temperature soluble tablet 5, the shape control wire 2 firstly forces the outer drum coating 1 to bulge under the supporting action of the shaping medium layer 3, and the shape control wire 2 recovers the shape after the shaping medium layer 3 is cracked, so that the outer drum coating 1 is driven to be flattened and compressed.
Referring to fig. 5, the stretching middle layer 4 is made of an elastic material to form a net structure, the low-temperature soluble piece 5 is made of saltpeter, the stretching middle layer 4 can meet the requirement of flattening and compressing the outer drum coating 1, the low-temperature soluble piece 5 is always kept at the central position to be combined with the trigger block 6, meanwhile, after stretching, meshes can accommodate the fractured shaping medium layer 3, the outer drum coating 1 can be fully flattened, and the trigger block 6 can be smoothly contacted with the low-temperature soluble piece 5.
The force transfer block 61 is made of a hard material with hardness higher than that of the shaping interlayer 3, the shaping interlayer 3 is made of a brittle heat conduction material, after the low-temperature capsule is slightly pressed, the force transfer block 61 transfers the pressure to the shaping interlayer 3, the shaping interlayer 3 can be broken and does not support the shape of the outer drum coating 1, and the two actions of leveling and refrigeration are triggered.
Example 2:
a preparation process of a low-temperature long-acting disinfectant for wounds comprises the following steps:
s1, cleaning 5 parts of scutellaria baicalensis, 4 parts of wild chrysanthemum, 9 parts of honeysuckle, 12 parts of angelica, 5 parts of fructus cnidii, 6 parts of humifuse euphorbia herb, 6 parts of saffron crocus and 6 parts of corydalis edulis according to parts by weight, crushing and grinding, then carrying out 150-mesh sieve treatment, and mixing and stirring the raw materials uniformly to obtain mixed powder;
s2, uniformly stirring and mixing 12 parts of water and the mixed powder, decocting the mixture for 30min by slow fire, then heating the water to 80 ℃, continuing to decoct for 25min, and continuously stirring the decoction;
s3, filtering after decoction, discarding filter residues, reserving filtrate, and decoloring the filtrate;
s4, adding 18 parts of medical alcohol, 5 parts of glycerol and 4 parts of dispersing agent into the decolored filtrate, and carrying out ultrasonic stirring and mixing while heating in a water bath to prepare a solution;
and S5, uniformly putting a proper amount of low-temperature capsules into the solution in an oxygen-free environment, and then sealing, packaging and warehousing.
The remainder was in accordance with example 1.
Example 3:
a preparation process of a low-temperature long-acting disinfectant for wounds comprises the following steps:
s1, cleaning 6 parts of scutellaria baicalensis, 5 parts of wild chrysanthemum, 10 parts of honeysuckle, 14 parts of angelica sinensis, 7 parts of fructus cnidii, 8 parts of humifuse euphorbia herb, 8 parts of saffron crocus and 7 parts of corydalis edulis according to parts by weight, crushing and grinding, then carrying out 200-mesh sieve treatment, and mixing and stirring the raw materials uniformly to obtain mixed powder;
s2, uniformly stirring and mixing 15 parts of water and the mixed powder, decocting the mixture for 40min by slow fire, then continuing to decoct for 30min when the water temperature is raised to 90 ℃, and continuously stirring the decoction;
s3, filtering after decoction, discarding filter residues, reserving filtrate, and decoloring the filtrate;
s4, adding 20 parts of medical alcohol, 10 parts of glycerol and 6 parts of dispersing agent into the decolored filtrate, and carrying out ultrasonic stirring and mixing while heating in a water bath to prepare a solution;
and S5, uniformly putting a proper amount of low-temperature capsules into the solution in an oxygen-free environment, and then sealing, packaging and warehousing.
The remainder was in accordance with example 1.
The invention can improve the disinfectant formula, uses mild traditional Chinese medicine raw materials, has various chemical components for promoting blood circulation, removing blood stasis, clearing heat, detoxifying, diminishing inflammation and relieving pain, can inhibit the growth of harmful bacteria around a wound, kill most harmful bacteria, avoid wound infection, simultaneously realize pus discharge and granulation, promote the healing of the wound and shorten the healing time of the wound, simultaneously, the doped low-temperature capsule is only slightly crushed when in use, and can cover the wound by absorbing the water contained in the disinfectant to trigger the double actions of compression and refrigeration, thereby reducing the contact area with the outside while reducing the loss of the disinfectant, on the other hand, the low temperature can achieve the effect of slight anesthesia, reduce the pain feeling brought by the disinfection of the wound, reduce the volatilization of the disinfectant and realize the effect of long-acting disinfection.
The above are merely preferred embodiments of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.

Claims (10)

1. A preparation process of a low-temperature long-acting disinfectant for wounds is characterized by comprising the following steps: the method comprises the following steps:
s1, cleaning 4-6 parts of scutellaria baicalensis, 3-5 parts of wild chrysanthemum, 8-10 parts of honeysuckle, 10-14 parts of angelica, 3-7 parts of fructus cnidii, 4-8 parts of humifuse euphorbia herb, 4-8 parts of saffron crocus and 5-7 parts of corydalis edulis according to parts by weight, crushing and grinding, treating by a 100-mesh and 200-mesh sieve, and mixing and stirring the raw materials uniformly to obtain mixed powder;
s2, uniformly stirring and mixing 10-15 parts of water and the mixed powder, decocting the mixture for 20-40min by slow fire, then continuously decocting for 20-30min when the water temperature is raised to 75-90 ℃, and continuously stirring the mixture during decoction;
s3, filtering after decoction, discarding filter residues, reserving filtrate, and decoloring the filtrate;
s4, adding 15-20 parts of medical alcohol, 1-10 parts of glycerol and 2-6 parts of dispersing agent into the decolored filtrate, and carrying out ultrasonic stirring and mixing while heating in a water bath to prepare a solution;
and S5, uniformly putting a proper amount of low-temperature capsules into the solution in an oxygen-free environment, and then sealing, packaging and warehousing.
2. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 1, wherein the preparation process comprises the following steps: the water in the step S2 is one of water for injection or sterile water.
3. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 1, wherein the preparation process comprises the following steps: the medical alcohol concentration in the step S4 is 80%, and the dispersing agent is one or more of sodium tetradecyl benzene sulfonate, polyethylene glycol, sodium dodecyl benzene sulfonate and ammonium sulfate.
4. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 1, wherein the preparation process comprises the following steps: the water bath heating temperature in the step S4 is 50-70 ℃.
5. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 1, wherein the preparation process comprises the following steps: the number of the low-temperature capsules in the step S5 is 1/3 ml-5 ml.
6. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 1, wherein the preparation process comprises the following steps: the low-temperature capsule in the step S5 comprises an outer drum coating (1), wherein the inner end of the outer drum coating (1) is connected with a pair of symmetrically distributed shape control wires (2), the inner end of each shape control wire (2) is connected with a matched shaping interlayer (3), the center of the inner end of the outer drum coating (1) is also connected with a stretching middle layer (4), the center of the stretching middle layer (4) is connected with a low-temperature dissolving piece (5) in an embedded manner, the inner end of the outer drum coating (1) is also connected with a pair of trigger blocks (6) corresponding to the low-temperature dissolving piece (5), and the trigger blocks (6) are connected with the outer end of the shaping interlayer (3).
7. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 6, wherein the preparation process comprises the following steps: the trigger block (6) comprises a force transmission block (61), a water absorption end (62) and a plurality of water guide fibers (63), the force transmission block (61) is connected between the shaping interlayer (3) and the outer drum coating (1), the water absorption end (62) is connected to one end, close to the shaping interlayer (3), of the force transmission block (61) in an embedded mode, the water guide fibers (63) are evenly connected to the water absorption end (62), and the water guide fibers (63) penetrate through the outer drum coating (1) and extend to the outer side.
8. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 6, wherein the preparation process comprises the following steps: the outer drum coating (1) is made of a flexible film-shaped material, the shape control wires (2) are made of an elastic material, and the shape control wires (2) elastically deform in the direction away from the low-temperature dissolving sheet (5).
9. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 6, wherein the preparation process comprises the following steps: the stretching middle layer (4) is made of an elastic material and is of a net structure, and the low-temperature dissolving sheet (5) is made of saltpeter.
10. The preparation process of the low-temperature long-acting disinfectant for wounds according to claim 7, wherein the preparation process comprises the following steps: the force transfer block (61) is made of a hard material with hardness higher than that of the shape-stabilized dielectric layer (3), and the shape-stabilized dielectric layer (3) is made of a brittle heat conduction material.
CN202110466977.2A 2021-04-28 2021-04-28 Preparation process of low-temperature long-acting disinfectant for wounds Withdrawn CN113304205A (en)

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