CN108743788A - A kind of Chinese medicine composition that treating fibroid, ovarian cyst and pelvic infecton, medicine pad and underpants - Google Patents
A kind of Chinese medicine composition that treating fibroid, ovarian cyst and pelvic infecton, medicine pad and underpants Download PDFInfo
- Publication number
- CN108743788A CN108743788A CN201810663975.0A CN201810663975A CN108743788A CN 108743788 A CN108743788 A CN 108743788A CN 201810663975 A CN201810663975 A CN 201810663975A CN 108743788 A CN108743788 A CN 108743788A
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- chinese medicine
- parts
- treatment
- health
- pad
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Abstract
Description
技术领域technical field
本发明涉及医药技术领域，具体是一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药组合物、药垫及内裤。The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition, a medicine pad and underwear for treating uterine fibroids, ovarian cysts and pelvic inflammatory disease.
背景技术Background technique
当今社会，随着生活节奏加快，工作压力变大，越来越多的女性朋友受到妇科疾病的困扰，其中子宫肌瘤、卵巢囊肿和盆腔炎等妇科疾病的发病率明显上升，并呈现年轻化趋势，成为威胁女性健康的杀手。In today's society, with the accelerated pace of life and increased work pressure, more and more female friends are troubled by gynecological diseases. Among them, the incidence of gynecological diseases such as uterine fibroids, ovarian cysts and pelvic inflammatory disease has increased significantly, and it is becoming younger trend, becoming a killer that threatens women's health.
目前，治疗子宫肌瘤、卵巢囊肿和盆腔炎的方法主要有药物治疗、手术治疗等多种方式，临床治疗研究显示，手术治疗患者风险大，承受的痛苦多，而药物治疗目前还没有非常有效的药物，因此疗效不大。因此，通过临床研究出一种治疗见效快、无反复的治疗子宫肌瘤、卵巢囊肿和盆腔炎的药物，同时突破传统常规用药方法，配合更加有利于药效直达患处的治疗方法，具有重要的意义。At present, the methods of treating uterine fibroids, ovarian cysts and pelvic inflammatory disease mainly include drug therapy, surgical treatment and other methods. Clinical treatment research shows that surgical treatment is risky and suffers a lot of pain, while drug treatment is not very effective yet. drugs, and therefore have little effect. Therefore, through clinical research, it is important to develop a drug for the treatment of uterine fibroids, ovarian cysts, and pelvic inflammatory disease that has a quick effect and no recurrence, and at the same time breaks through the traditional conventional medication method, and cooperates with a treatment method that is more conducive to the direct effect of the drug on the affected area. significance.
发明内容Contents of the invention
为克服以上技术问题，本发明提供了一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药组合物，本发明所述中药组合物治疗见效快，无反复。In order to overcome the above technical problems, the present invention provides a traditional Chinese medicine composition for treating uterine fibroids, ovarian cysts and pelvic inflammatory disease. The traditional Chinese medicine composition of the present invention has quick therapeutic effect and no recurrence.
为实现上述目的，本发明采用如下技术方案：To achieve the above object, the present invention adopts the following technical solutions:
一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药组合物，包括以下重量份的中药组分：艾叶10-15份、透骨草10-15份、当归10-15份、连翘10-15 份、赤白芍各10-15份、皂刺10-15份、内金12-17份、败酱草10-15份、元胡10-15份、炒香附10-15份、浙贝10-15份、炮山甲5-8份、丹参27-32 份。A traditional Chinese medicine composition for treating uterine fibroids, ovarian cysts and pelvic inflammatory disease, comprising the following traditional Chinese medicine components in parts by weight: 10-15 parts of Artemisia argyi, 10-15 parts of Speranthema sinensis, 10-15 parts of angelica, 10-10 parts of forsythia 15 parts, 10-15 parts of Radix Paeoniae Alba, 10-15 parts of Soapthorn, 12-17 parts of Neijin, 10-15 parts of Patrinia, 10-15 parts of Yuanhu, 10-15 parts of fried incense, Zhejiang 10-15 parts of shellfish, 5-8 parts of Paoshanjia, 27-32 parts of Salvia miltiorrhiza.
作为优选，所述的治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药组合物包括以下重量份的中药组分：艾叶12份、透骨草12份、当归12份、连翘12份、赤白芍各12份、皂刺12份、内金15份、败酱草12份、元胡12份、炒香附 12份、浙贝12份、炮山甲6份、丹参30份。As a preference, the traditional Chinese medicine composition for treating uterine fibroids, ovarian cysts and pelvic inflammatory disease includes the following Chinese medicine components in parts by weight: 12 parts of Folium Artemisiae Argyi, 12 parts of Sperancae, 12 parts of Angelica sinensis, 12 parts of Forsythia, Chibai 12 parts of peony, 12 parts of saponins, 15 parts of Neijin, 12 parts of Patrinia, 12 parts of Yuanhu, 12 parts of fried incense, 12 parts of Zhebei, 6 parts of Paoshanjia, and 30 parts of Danshen.
本发明的目的之二是提供一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药保健护垫，所述保健护垫可以固定在内裤裤裆处，可以自加热，实现中药熏蒸效果，药效可直接作用于病患的会阴部，药物有效成分通过气味分泌直达患处迅速起效，药物见效快，使用方便；而且本发明所述保健护垫具有抗菌的作用，可有效避免使用时人体分泌物导致细菌滋生，而引起的二次感染。The second object of the present invention is to provide a traditional Chinese medicine health care pad for the treatment of uterine fibroids, ovarian cysts and pelvic inflammatory disease. It directly acts on the perineum of the patient, and the active ingredients of the medicine directly reach the affected area through the secretion of odor and take effect quickly. Bacteria grow and cause secondary infection.
为实现上述目的，本发明采用如下技术方案：To achieve the above object, the present invention adopts the following technical solutions:
一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药保健护垫，所述中药保健垫从上到下依次由抗菌吸附层、中药药包层和自发热层组成，所述中药药包层内装有上述的中药组合物的提取物；所述抗菌吸附层包括上层的纳米银纤维和活性炭纤维抗菌纺织布，和下层的活性炭吸附层。A traditional Chinese medicine health care pad for treating uterine fibroids, ovarian cysts and pelvic inflammatory disease. There is the extract of the above-mentioned traditional Chinese medicine composition; the antibacterial adsorption layer includes the upper layer of nano-silver fiber and activated carbon fiber antibacterial textile cloth, and the lower layer of activated carbon adsorption layer.
作为优选，所述抗菌吸附层的下表面和中药药包层的上表面上分别设置有相互配合的粘扣，所述自发热层的上、下表面上均设置有粘胶，所述粘胶上设置有保护贴纸。As a preference, the lower surface of the antibacterial adsorption layer and the upper surface of the traditional Chinese medicine coating are respectively provided with adhesive buttons that cooperate with each other, and viscose is provided on the upper and lower surfaces of the self-heating layer, and the viscose There is a protective sticker on it.
作为优选，所述自发热层包括不透气外袋和装在外袋内的无纺布内袋，所述无纺布内袋内装有铁粉，所述无纺布内袋的上、下表面上均设置有粘胶，所述粘胶上设置有保护贴纸。Preferably, the self-heating layer includes an air-tight outer bag and a non-woven inner bag contained in the outer bag, iron powder is housed in the non-woven inner bag, and the upper and lower surfaces of the non-woven inner bag are both Adhesive is provided, and a protective sticker is provided on the adhesive.
作为优选，所述中药药包层包括用于封装中药的药包，所述药包上表面上密布设置有透气孔，所述药包下表面上设置有导热片，所述药包一侧开口，其开口处设置有粘扣。Preferably, the traditional Chinese medicine coating includes a drug bag for encapsulating traditional Chinese medicine, the upper surface of the drug bag is densely covered with air holes, the lower surface of the drug bag is provided with a heat conduction sheet, and one side of the drug bag is opened. , the opening is provided with a Velcro.
作为优选，所述中药组合物的提取物由以下方法制备：按要求称取各药材放入发酵罐内，加入发酵菌剂和水，混合均匀，于35℃条件下发酵72h，将发酵物打碎，加入到CO2超临界萃取器中，乙醇作为夹带剂，夹带剂占总萃取溶剂的体积百分比为4％，萃取压力20MPa，温度60℃，CO2流量2ml/g药材·min，萃取时间180min，得超临界萃取物，备用；萃取后的残渣混中加入60％乙醇，投入微波萃取装置中进行微波萃取，萃取3次，每次15分钟，合并萃取液，浓缩，加到D101大孔吸附树脂柱上，60％乙醇洗脱，收集5倍量柱体积洗脱液，减压回收乙醇，浓缩并干燥成粉末，得中药组合物的提取物。As a preference, the extract of the traditional Chinese medicine composition is prepared by the following method: Weigh each medicinal material as required and put it into a fermenter, add fermentation bacteria and water, mix evenly, ferment at 35°C for 72 hours, and beat the fermented product crushed, added to CO2 supercritical extractor, ethanol as entrainer, entrainer accounted for 4% volume percent of the total extraction solvent, extraction pressure 20MPa, temperature 60 ° C, CO2 flow rate 2ml/g medicinal material min, extraction time 180min, Obtain the supercritical extract and set it aside; add 60% ethanol to the extracted residue, put it into a microwave extraction device for microwave extraction, extract 3 times, each time for 15 minutes, combine the extracts, concentrate, and add to D101 macroporous adsorption resin On the column, elute with 60% ethanol, collect 5 times the column volume eluate, recover the ethanol under reduced pressure, concentrate and dry into powder to obtain the extract of the traditional Chinese medicine composition.
本发明的目的之三是提供一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的保健内裤，所述保健内裤的裤裆处设置有上述的保健护垫，中药熏蒸效果，药效可直接作用于病患的会阴处，药物见效快，使用方便，所述保健内裤还有按摩功能和磁疗功能，而且对肚脐和后腰处的穴位起到中药保健，辅助治疗的效果。The third object of the present invention is to provide a kind of health-care underpants for the treatment of uterine fibroids, ovarian cysts and pelvic inflammatory disease. In the perineum of the patient, the medicine takes effect quickly and is easy to use. The health-care underpants also have a massage function and a magnetic therapy function, and have the effects of traditional Chinese medicine health care and auxiliary treatment on the acupuncture points at the navel and the lower back.
为实现上述目的，本发明采用如下技术方案：To achieve the above object, the present invention adopts the following technical solutions:
一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的保健内裤，包括内裤体、裆体和弹性裤腰，所述弹性裤腰靠近肚脐和后腰处的内表面上设置有夹层，所述夹层上设置有磁石按摩颗粒和透气孔，所述夹层内放置有中药垫，所述中药垫包括通过粘胶粘合在一起的中药药包层和自发热层；所述裆体的内表面上可拆卸的设置有权利要求3-7任一所述的中药保健护垫；所述弹性裤腰的内表面上对应穴位处设置有弹性按摩凸起，所述按摩凸起内部中空，其内填充有磁石颗粒、电气石颗粒和中药颗粒，所述按摩凸起上密布设置有透气孔。A health-care underpants for the treatment of uterine fibroids, ovarian cysts and pelvic inflammatory disease, comprising a panty body, a crotch body and an elastic waistband, the inner surface of the elastic waistband near the navel and the back waist is provided with a sandwich layer, and the sandwich layer is provided with Magnet massage particles and air holes, a Chinese medicine pad is placed in the interlayer, and the Chinese medicine pad includes a Chinese medicine coating and a self-heating layer bonded together by glue; the detachable setting on the inner surface of the crotch There is the traditional Chinese medicine health care pad described in any one of claims 3-7; elastic massage protrusions are arranged on the corresponding acupuncture points on the inner surface of the elastic trouser waist, and the interior of the massage protrusions is hollow, filled with magnet particles, electric stone particles and traditional Chinese medicine particles, and the massage protrusions are densely covered with ventilation holes.
作为优选，所述内裤体上密布设置有透气孔，所述内裤体选用远红外纤维、负离子纤维和胶原蛋白粘胶纤维纺织布料。As a preference, the underpants body is densely covered with ventilation holes, and the underpants body is made of far-infrared fibers, negative ion fibers and collagen viscose fiber woven fabrics.
作为优选，所述夹层内放置的中药垫内装有上述的中药组合物的提取物。As a preference, the Chinese medicine pad placed in the interlayer is filled with the extract of the above-mentioned Chinese medicine composition.
有益效果Beneficial effect
(1)本发明所述的治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药组合物，用于治疗子宫肌瘤、卵巢囊肿和盆腔炎，治疗见效快，无反复，而且所用中药原料来源丰富易得，成本低廉。(1) The Chinese medicine composition for the treatment of hysteromyoma, ovarian cyst and pelvic inflammatory disease according to the present invention is used for the treatment of hysteromyoma, ovarian cyst and pelvic inflammatory disease, and the treatment is effective quickly without repetition, and the source of Chinese medicine raw materials used is abundant and easy Yep, it's cheap.
(2)本发明所述的治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药保健护垫，可以固定在内裤裤裆处，可以自加热，实现中药熏蒸效果，药效可直接作用于病患的会阴部，药物有效成分通过气味分泌直达患处宫迅速起效，药物见效快，使用方便，避免了长期口服用药导致患者肝脏、肾脏、肠胃损害的弊端，坚持使用可达到直接彻底杀灭病菌的作用；而且本发明所述保健护垫具有抗菌的作用，可有效避免使用时人体分泌物导致细菌滋生而引起的二次感染。(2) The traditional Chinese medicine health care pad for the treatment of uterine fibroids, ovarian cysts and pelvic inflammatory disease according to the present invention can be fixed at the crotch of the underwear, can be self-heated, and realizes the fumigation effect of traditional Chinese medicine, and the drug effect can directly act on the meeting of the patient. In the genitals, the active ingredients of the drug directly reach the affected part of the uterus through the secretion of odor and take effect quickly. The drug takes effect quickly and is easy to use, avoiding the disadvantages of liver, kidney, and gastrointestinal damage caused by long-term oral medication. Persistent use can directly and completely kill germs; Moreover, the health care pad of the present invention has an antibacterial effect, which can effectively avoid secondary infection caused by bacterial growth caused by human body secretions during use.
(3)本发明所述的治疗子宫肌瘤、卵巢囊肿和盆腔炎的保健内裤，裤裆处设置有上述的保健护垫，中药熏蒸效果，药物见效快，使用方便，所述保健内裤还有按摩功能和磁疗功能，同时也通过生物磁促进女性的血液循环，有利于保养女性生殖器官，而且对肚脐和后腰处的穴位起到中药保健、辅助治疗的效果。(3) The health-care underpants for the treatment of uterine fibroids, ovarian cysts and pelvic inflammatory disease according to the present invention, the crotch place is provided with the above-mentioned health-care pads, the fumigation effect of traditional Chinese medicine, the medicine takes effect quickly, and is easy to use. The health-care underwear also has massage Function and magnetic therapy function, and at the same time promote the blood circulation of women through biomagnetism, which is beneficial to the maintenance of female reproductive organs, and has the effect of traditional Chinese medicine health care and auxiliary treatment on the acupuncture points at the navel and lower back.
附图说明Description of drawings
图1为发明实施例3保健内裤的结构示意图。Fig. 1 is the structural representation of health-care underpants of embodiment 3 of the invention.
图2为发明实施例2保健护垫的结构示意图。Fig. 2 is a schematic structural view of a health care pad according to Embodiment 2 of the invention.
图中：1:内裤体 2:裆体 3:裤腰 4：抗菌吸附层 5:中药药包层 6：自发热层 7：透气孔 8：中药保健垫 9:弹性按摩凸起 10:夹层。In the figure: 1: underwear body 2: crotch body 3: trouser waist 4: antibacterial adsorption layer 5: traditional Chinese medicine coating 6: self-heating layer 7: ventilation holes 8: traditional Chinese medicine health care pad 9: elastic massage protrusions 10: interlayer.
具体实施方式Detailed ways
下面结合实施例，并结合附图对本发明的技术方案做进一步具体说明。The technical solution of the present invention will be further specifically described below in conjunction with the embodiments and the accompanying drawings.
实施例1Example 1
一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药组合物，包括以下重量份的中药组分：艾叶12份、透骨草12份、当归12份、连翘12份、赤白芍各 12份、皂刺12份、内金15份、败酱草12份、元胡12份、炒香附12份、浙贝12份、炮山甲6份、丹参30份。A traditional Chinese medicine composition for treating uterine fibroids, ovarian cysts and pelvic inflammatory disease, comprising the following traditional Chinese medicine components in parts by weight: 12 parts of Artemisia argyi leaves, 12 parts of Speranthema japonicus, 12 parts of Angelica sinensis, 12 parts of forsythia, 12 parts of Radix Paeoniae Rubra each 12 parts, 12 parts of saponins, 15 parts of Neijin, 12 parts of Patrinia, 12 parts of Yuanhu, 12 parts of fried incense, 12 parts of Zhebei, 6 parts of Paoshanjia, and 30 parts of Danshen.
药物使用方法：内服每日2次，水煎服，一日一剂，分早晚两次服用， 30日为一个疗程，连续三个疗程效果佳。无禁忌，保存于阴凉干燥处。Drug usage method: oral administration twice a day, decoction in water, one dose a day, twice in the morning and evening, 30 days as a course of treatment, three consecutive courses of treatment are effective. No contraindications, keep in a cool dry place.
实施例2Example 2
如图1所示，一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药保健护垫，所述中药保健垫从上到下依次由抗菌吸附层4、中药药包层5和自发热层6 组成，所述中药药包层5内装有实施例1所述的中药组合物的提取物；所述抗菌吸附层4包括上层的纳米银纤维和活性炭纤维抗菌纺织布，和下层的活性炭吸附层。所述中药保健垫可以固定在内裤裤裆处，可以自加热，实现中药熏蒸效果，药效可直接作用于病患的会阴处，药物见效快，使用方便，避免了长期口服用药导致患者肝脏、肾脏、肠胃损害的弊端，坚持使用可达到直接彻底杀灭病菌的作用。As shown in Figure 1, a kind of Chinese medicine health care pad for the treatment of uterine fibroids, ovarian cysts and pelvic inflammatory disease, said Chinese medicine health care pad is successively composed of antibacterial adsorption layer 4, Chinese medicine drug coating layer 5 and self-heating layer 6 from top to bottom Composition, the extract of the traditional Chinese medicine composition described in embodiment 1 is housed in the described Chinese medicine coating layer 5; The antibacterial adsorption layer 4 includes the upper layer of nano-silver fiber and activated carbon fiber antibacterial textile cloth, and the lower layer of activated carbon adsorption layer. The traditional Chinese medicine health care pad can be fixed at the crotch of the underwear, and can be self-heated to achieve the fumigation effect of traditional Chinese medicine. The medicine effect can directly act on the perineum of the patient. 1. Disadvantages of gastrointestinal damage, insisting on using it can achieve the effect of directly and completely killing germs.
而且本发明所述保健护垫具有抗菌的作用，银纤维和活性炭纤维具有抗菌消炎防过敏的功能，有效的阻断细菌的侵袭和病毒的传播，活性炭吸附层具有吸附除湿的功能，可以起到吸附人体分泌物，抗菌除臭，防止细菌感染和防止分泌物污染中药包的作用，可有效避免使用时人体分泌物导致细菌滋生，而引起的二次感染。And the health-care pad of the present invention has antibacterial effect, and silver fiber and activated carbon fiber have the function of antibacterial, anti-inflammatory and antiallergic, effectively block the invasion of bacteria and the propagation of virus, and the activated carbon adsorption layer has the function of adsorption and dehumidification, which can play Adsorbing human secretions, antibacterial and deodorizing, preventing bacterial infection and preventing secretions from contaminating traditional Chinese medicine bags can effectively avoid secondary infections caused by human secretions that cause bacterial growth during use.
作为优选，所述抗菌吸附层4的下表面和中药药包层5的上表面上分别设置有相互配合的粘扣，抗菌吸附层4方便拆洗，所述自发热层6的上、下表面上均设置有粘胶，所述粘胶上设置有保护贴纸，自发热层6可以方便的与药药包层5粘贴在一起，使用方便，而且还能方便地粘在内裤上，方便替换。As preferably, the lower surface of the antibacterial adsorption layer 4 and the upper surface of the traditional Chinese medicine coating 5 are respectively provided with hook and loop buttons that cooperate with each other, the antibacterial adsorption layer 4 is convenient to remove and wash, and the upper and lower surfaces of the self-heating layer 6 All are provided with viscose, and the viscose is provided with protective stickers, and the self-heating layer 6 can be easily pasted together with the medicine coating layer 5, which is convenient to use, and can also be easily pasted on the underwear for easy replacement.
作为优选，所述自发热层6包括不透气外袋和装在外袋内的无纺布内袋，所述无纺布内袋内装有铁粉，所述无纺布内袋的上、下表面上均设置有粘胶，所述粘胶上设置有保护贴纸，使用时，先撕开外袋，使空气通过无纺布内袋与铁粉接触，然后氧化发热，粘胶的设计方便固定使用。As preferably, the self-heating layer 6 includes an air-tight outer bag and a non-woven inner bag contained in the outer bag, iron powder is housed in the non-woven inner bag, and the upper and lower surfaces of the non-woven inner bag All are equipped with viscose, and the viscose is provided with a protective sticker. When using, first tear the outer bag, let the air pass through the non-woven inner bag to contact the iron powder, and then oxidize and generate heat. The viscose design is convenient for fixed use.
作为优选，所述中药药包层5包括用于封装中药的药包，所述药包上表面上密布设置有透气孔，可以使中药更加容易穿透药包，所述药包下表面上设置有导热片，导热效果更佳，可以实现快速导热，有利于中药药效发挥，所述药包一侧开口，其开口处设置有粘扣，可以方便地替换其内的中药。As a preference, the traditional Chinese medicine coating 5 includes a drug bag for encapsulating traditional Chinese medicine, the upper surface of the drug bag is densely covered with air holes, which can make it easier for the Chinese medicine to penetrate the drug bag, and the lower surface of the drug bag is provided with There is a heat conduction sheet, which has a better heat conduction effect, can realize rapid heat conduction, and is conducive to the efficacy of traditional Chinese medicine. The medicine bag is opened on one side, and the opening is provided with a sticky button, which can easily replace the traditional Chinese medicine in it.
作为优选，所述中药组合物的提取物由以下方法制备：按要求称取各药材放入发酵罐内，加入发酵菌剂和水，混合均匀，于35℃条件下发酵72h，将发酵物打碎，加入到CO2超临界萃取器中，乙醇作为夹带剂，夹带剂占总萃取溶剂的体积百分比为4％，萃取压力20MPa，温度60℃，CO2流量2ml/g药材·min，萃取时间180min，得超临界萃取物，备用；萃取后的残渣混中加入60％乙醇，投入微波萃取装置中进行微波萃取，萃取3次，每次15分钟，合并萃取液，浓缩，加到D101大孔吸附树脂柱上，60％乙醇洗脱，收集5倍量柱体积洗脱液，减压回收乙醇，浓缩并干燥成粉末，得中药组合物的提取物。通过微生物发酵，不但去除原药的毒副作用，而且使药材内的有效成分更加容易提取，CO2超临界萃取和微波萃取相结合，有效提高药材内有效成分的提取率。As a preference, the extract of the traditional Chinese medicine composition is prepared by the following method: Weigh each medicinal material as required and put it into a fermenter, add fermentation bacteria and water, mix evenly, ferment at 35°C for 72 hours, and beat the fermented product crushed, added to CO2 supercritical extractor, ethanol as entrainer, entrainer accounted for 4% volume percent of the total extraction solvent, extraction pressure 20MPa, temperature 60 ° C, CO2 flow rate 2ml/g medicinal material min, extraction time 180min, Obtain the supercritical extract and set it aside; add 60% ethanol to the extracted residue, put it into a microwave extraction device for microwave extraction, extract 3 times, each time for 15 minutes, combine the extracts, concentrate, and add to D101 macroporous adsorption resin On the column, elute with 60% ethanol, collect 5 times the column volume eluate, recover the ethanol under reduced pressure, concentrate and dry into powder to obtain the extract of the traditional Chinese medicine composition. Through microbial fermentation, it not only removes the toxic and side effects of the original medicine, but also makes it easier to extract the active ingredients in the medicinal materials. The combination of CO2 supercritical extraction and microwave extraction can effectively improve the extraction rate of active ingredients in the medicinal materials.
本发明治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药保健护垫的用法：将药垫贴于内裤上会阴部相对应的位置，中药和自发热层每日更换一次，抗菌吸附层每日拆洗替换，10日为一个疗程，连续三个疗程效果佳。无禁忌，保存于阴凉干燥处。The usage of the traditional Chinese medicine health care pad for the treatment of uterine fibroids, ovarian cysts and pelvic inflammatory disease of the present invention: paste the medicine pad on the corresponding position of the perineum on the underwear, replace the traditional Chinese medicine and the self-heating layer once a day, and remove and wash the antibacterial adsorption layer every day Replacement, 10 days is a course of treatment, and the effect of three consecutive courses of treatment is good. No contraindications, keep in a cool dry place.
实施例3Example 3
如图2所示，一种治疗子宫肌瘤、卵巢囊肿和盆腔炎的保健内裤，包括内裤体1、裆体2和弹性裤腰3，所述弹性裤腰3靠近肚脐和后腰处的内表面上设置有夹层，所述夹层上设置有磁石按摩颗粒和透气孔，所述夹层内放置有中药垫，所述中药垫包括通过粘胶粘合在一起的中药药包层和自发热层，可以对肚脐和后腰处的穴位起到中药保健的效果；所述裆体2的内表面上可拆卸的设置有权利要求3-7任一所述的中药保健护垫；所述弹性裤腰3的内表面上对应穴位处设置有弹性按摩凸起，可以对穴位起到按摩保健的作用，所述按摩凸起内部中空，其内填充有磁石颗粒、电气石颗粒和中药颗粒，所述按摩凸起上密布设置有透气孔，可起到磁疗的效果，电气石能够永久的产生微电流，能起到促使血液循环、顺畅的作用，另外电气石还能释放负离子，这些负离子能够调节人体离子平，所述按摩凸起上密布设置有透气孔，可以使中药药效通过透气孔作用到穴位，保健效果更佳。As shown in Figure 2, a kind of health-care underpants for treating uterine fibroids, ovarian cysts and pelvic inflammatory disease comprises underwear body 1, crotch body 2 and elastic trousers waist 3, and described elastic trousers waist 3 is on the inner surface near navel and back waist An interlayer is provided, and the interlayer is provided with magnet massage particles and ventilation holes, and a traditional Chinese medicine pad is placed in the interlayer, and the traditional Chinese medicine pad includes a traditional Chinese medicine cladding and a self-heating layer bonded together by glue, which can The acupuncture points at the navel and the back waist play the effect of traditional Chinese medicine health care; the inner surface of the crotch body 2 is detachably provided with the Chinese medicine health care pad described in any one of claims 3-7; the inner part of the elastic trouser waist 3 Elastic massage protrusions are arranged on the corresponding acupuncture points on the surface, which can play the role of massage and health care for the acupuncture points. The interior of the massage protrusions is hollow and filled with magnetite particles, tourmaline particles and traditional Chinese medicine particles. Densely covered with air holes, can play a magnetic therapy effect, tourmaline can permanently generate micro-current, can play a role in promoting blood circulation, smooth, in addition tourmaline can also release negative ions, these negative ions can adjust the body's ion level, Air holes are densely arranged on the massage protrusions, so that the medicinal effect of traditional Chinese medicine can be applied to acupuncture points through the air holes, and the health care effect is better.
作为优选，所述内裤体1上密布设置有透气孔7，舒适透气，穿着更佳舒适，所述内裤体1选用远红外纤维、负离子纤维和胶原蛋白粘胶纤维纺织布料，远红外纤维可以产生三效抗菌远红外光波，促进人体局部微循环、抑菌，负离子纤维具有杀菌的功能，胶原蛋白粘胶纤维舒适亲肤，使内裤体具有抑菌保健作用。As a preference, the underpants body 1 is densely covered with air holes 7, comfortable and breathable, and more comfortable to wear. The underpants body 1 is made of far-infrared fibers, anion fibers and collagen viscose fiber textile fabrics, and the far-infrared fibers can produce The three-effect antibacterial far-infrared light wave can promote the local microcirculation of the human body and inhibit bacteria. The negative ion fiber has the function of sterilization. The collagen viscose fiber is comfortable and skin-friendly, so that the underwear body has the effect of antibacterial and health care.
作为优选，所述夹层内放置的中药垫内装有上述的中药组合物的提取物。As a preference, the Chinese medicine pad placed in the interlayer is filled with the extract of the above-mentioned Chinese medicine composition.
本发明治疗子宫肌瘤、卵巢囊肿和盆腔炎的中药保健内裤的用法：日常贴身穿着，每日更换一次，10日为一个疗程，连续三个疗程效果佳。无禁忌，保存于阴凉干燥处。The usage of the traditional Chinese medicine health-care underpants for treating uterine fibroids, ovarian cysts and pelvic inflammatory disease of the present invention is as follows: daily close fitting, replaced once a day, 10 days is a course of treatment, and the effect of three consecutive courses of treatment is good. No contraindications, keep in a cool dry place.
实施例4Example 4
一.本发明实施例1抗炎、体外抗菌实验One. Anti-inflammation and in vitro antibacterial experiment of embodiment 1 of the present invention
1.抗炎试验：将60只ICR品系小鼠随机分为2组：对照组、受试组，每组30只，用二甲苯涂于各组小鼠右耳前后两面，每鼠0.03mL，致炎30min 后，对对照组小鼠右耳前后两面涂生理盐水，对受试组小鼠右耳前后两面涂抹本发明实施例1所述中药组合物的药粉(将中药组合物粉碎后的粉末)调成的糊状物，30min后断颈处死小鼠，用6mm直径打孔器分别在小鼠左右两耳同一部位打下圆耳片，于精密扭力天平称量，每鼠右耳片重量减去左耳片重量即为炎症组织肿胀度，比较受试组和对照组肿胀度差异，并对实验数据进行检验处理，结果见表1：1. Anti-inflammatory test: 60 ICR strain mice were randomly divided into 2 groups: the control group and the test group, 30 in each group, and xylene was applied to the front and back sides of the right ear of the mice in each group, 0.03mL per mouse, After causing inflammation for 30min, apply physiological saline to the front and rear sides of the right ear of the mice of the control group, and smear the medicated powder of the Chinese medicine composition described in Example 1 of the present invention to the front and back sides of the right ear of the mice of the test group (the powder after the Chinese medicine composition is pulverized) ), the mice were killed by neck breaking after 30 minutes, and round ear pieces were respectively punched on the same part of the left and right ears of the mouse with a 6mm diameter puncher, weighed on a precision torque balance, and the weight of the right ear piece of each mouse decreased The weight of the left ear piece is the degree of swelling of the inflammatory tissue. The difference in swelling between the test group and the control group was compared, and the experimental data was tested and processed. The results are shown in Table 1:
表1.小鼠炎症组织肿胀度Table 1. Swelling degree of inflammatory tissue in mice
从表1可以看出，受试组小鼠炎症组织肿胀度与对照组相比具有显著性差异，说明本发明实施例1中药组合物有抗炎作用。It can be seen from Table 1 that the degree of swelling of the inflammatory tissue of the mice in the test group is significantly different from that in the control group, indicating that the traditional Chinese medicine composition of Example 1 of the present invention has an anti-inflammatory effect.
2.体外抗菌试验：2. In vitro antibacterial test:
试验菌株：金黄色葡萄球菌(ATCC25923)、大肠杆菌(441490)、乙型溶血性链球菌(32210)、白色念珠菌(98100)、铜绿假单胞菌(ATCC27853)、新型隐球菌(ATCC32264).Test strains: Staphylococcus aureus (ATCC25923), Escherichia coli (441490), beta-hemolytic streptococcus (32210), Candida albicans (98100), Pseudomonas aeruginosa (ATCC27853), Cryptococcus neoformans (ATCC32264).
实验方法：取金黄色葡萄球菌(ATCC25923)、大肠杆菌(441490)、乙型溶血性链球菌(32210)、白色念珠菌(98100)、铜绿假单胞菌(ATCC27853)、新型隐球菌(ATCC32264)少许，分别接种于培养基中，37℃培养18h,将培养基做10-3稀释，将实施例1作为受试药，采用二倍稀释法测定其最低抑菌和最低杀菌浓度，实验结果如表2、表3所示。Experimental method: take Staphylococcus aureus (ATCC25923), Escherichia coli (441490), beta-hemolytic streptococcus (32210), Candida albicans (98100), Pseudomonas aeruginosa (ATCC27853), Cryptococcus neoformans (ATCC32264) A small amount was inoculated in the culture medium respectively, cultivated at 37°C for 18h, and diluted the culture medium by 10 −3 . Using Example 1 as the test drug, the minimum inhibitory and minimum bactericidal concentrations were measured by the double dilution method. The experimental results are as follows: Shown in Table 2 and Table 3.
表2.最低抑菌浓度结果Table 2. Minimum Inhibitory Concentration Results
表3.最低杀菌浓度结果Table 3. Minimum Bactericidal Concentration Results
体外抑菌试验显示，本发明实施例1所述中药组合物对妇科生殖系统炎症等常见致病菌有抑菌杀菌作用。Antibacterial tests in vitro show that the traditional Chinese medicine composition described in Example 1 of the present invention has antibacterial and bactericidal effects on common pathogenic bacteria such as gynecological reproductive system inflammation.
二.本发明实施例2体外抗菌试验Two. In vitro antibacterial test of embodiment 2 of the present invention
采用一定的培养基对新近分离的细菌或霉菌进行培养，观察本发明实施例2的体外抑菌作用。A certain culture medium was used to cultivate newly isolated bacteria or molds, and the in vitro antibacterial effect of Example 2 of the present invention was observed.
试验菌株：金黄色葡萄球菌(ATCC25923)、大肠杆菌(441490)、乙型溶血性链球菌(32210)、白色念珠菌(98100)。Test strains: Staphylococcus aureus (ATCC25923), Escherichia coli (441490), beta-hemolytic streptococcus (32210), Candida albicans (98100).
实验方法：取金黄色葡萄球菌(ATCC25923)、大肠杆菌(441490)、乙型溶血性链球菌(32210)菌株、白色念珠菌菌株少许，分别接种于培养基中，37℃培养18h。将上述培养基加去离子水10-3稀释，然后将培养基均匀涂覆于实施例2所述护垫的抗菌吸附层上，12h后用显微镜观察细菌滋生情况，观察结果显示，细菌数量明显减少，试验证明本发明实施例2所述护垫的抗菌吸附层对细菌具有有效地抑制作用。而且，经观察抗菌吸附层下面的中药包中药包上没有出现细菌滋生，说明抗菌吸附层可有效的阻断细菌的侵袭和病毒的传播，防止细菌感染和防止分泌物污染中药包。Experimental method: take Staphylococcus aureus (ATCC25923), Escherichia coli (441490), beta-hemolytic streptococcus (32210) strains, and Candida albicans strains, inoculate them in culture medium respectively, and incubate at 37°C for 18 hours. Dilute the above-mentioned culture medium with deionized water 10 −3 , then evenly coat the culture medium on the antibacterial adsorption layer of the pad described in Example 2, and observe the growth of bacteria with a microscope after 12 hours. The observation results show that the number of bacteria is significantly The test proves that the antibacterial adsorption layer of the pad described in Example 2 of the present invention has an effective inhibitory effect on bacteria. Moreover, it was observed that no bacterial growth occurred on the traditional Chinese medicine package under the antibacterial adsorption layer, indicating that the antibacterial adsorption layer can effectively block the invasion of bacteria and the spread of viruses, prevent bacterial infection and prevent secretions from polluting the traditional Chinese medicine package.
三.临床试验3. Clinical trials
1.子宫肌瘤治疗临床试验1. Clinical trials on the treatment of uterine fibroids
设6组治疗组，每组病患50例，每组从治疗之日起10天为一个疗程，三个疗程为观察期，观察期到后在医进行B超检查，判断疗效。治疗组1，服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用；治疗组2使用实施例2所述中药护垫，将护垫贴于内裤上会阴部相对应的位置，每日更换一次；治疗组3使用实施例3所述内裤，每日替换一次；治疗组4服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用，同时配合使用实施例2所述中药护垫，将护垫贴于内裤上会阴部相对应的位置，每日更换一次；治疗组5服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用，同时配合使用实施例3所述内裤，每日替换一次；治疗组6采用常规治疗药，按成药说明坚持用药。There are 6 treatment groups, 50 patients in each group, 10 days from the day of treatment for each group as a course of treatment, and three courses of treatment as an observation period. After the observation period, B-ultrasound examination will be performed in the hospital to judge the curative effect. Treatment group 1 took the traditional Chinese medicine described in Example 1, twice a day, decocted in water, one dose a day, and took it twice in the morning and evening; Treatment group 2 used the traditional Chinese medicine pad described in Example 2, and stuck the pad on the The position corresponding to the perineum on the underpants was replaced once a day; the treatment group 3 used the underpants described in Example 3 and was replaced once a day; the treatment group 4 took the traditional Chinese medicine described in Example 1, twice a day, decocted in water, One dose a day, take it twice in the morning and evening, and use the traditional Chinese medicine pad described in Example 2 at the same time, stick the pad on the corresponding position of the perineum on the underwear, and replace it once a day; Said traditional Chinese medicine, 2 times a day, decocted in water, one dose a day, take twice in the morning and evening, and use the underpants described in Example 3 at the same time, replace once a day; treatment group 6 adopts conventional therapeutic medicine, adhere to the instructions of the patented medicine medication.
疗效判定标准：①痊愈：肌瘤消失，子宫内恢复正常，其他临床症状彻底消失；②显效：肌瘤明显变小，其他临床症状明显好转；③有效：肌瘤变小，其他临床症状有好转；④无效：治疗前后症状无改变。Criteria for judging curative effect: ①Healed: fibroids disappear, the uterus returns to normal, and other clinical symptoms completely disappear; ②Significantly effective: Fibroids become smaller and other clinical symptoms are obviously improved; ③Effective: Fibroids become smaller and other clinical symptoms improve ; ④ invalid: no change in symptoms before and after treatment.
具体疗效见表4所示。The specific curative effect is shown in Table 4.
表4.疗效对比Table 4. Comparison of efficacy
由表4数据可以看出，与对照组相比，本发明三个实施例的疗效都有较大进步，其中治疗组1与对比组相比，治疗效果显著改观，疗效明显，说明本发明所述中药组合物对子宫肌瘤具有较好的疗效。治疗组2、3与治疗组1 相比，疗效有了进一步的提升，说明本发明所述的中药熏蒸法，药物直接作用于会阴部，药物有效成分通过气味分泌直达患处迅速起效，与传统的口服疗法相比，具有见效快、直达患处的药量多的优点。治疗组3的药效又有进一步提升，说明药物熏蒸疗法和经脉穴位磁疗按摩相结合，可以达到更好的治疗效果。治疗组4和5说明本发明药物口服再配合药物熏蒸可达到最佳的疗效。As can be seen from the data in Table 4, compared with the matched group, the curative effects of the three embodiments of the present invention all have greater progress, wherein the treatment group 1 is compared with the contrast group, the therapeutic effect is significantly improved, and the curative effect is obvious, illustrating that the present invention The traditional Chinese medicine composition has a good curative effect on uterine fibroids. Compared with treatment group 1, treatment groups 2 and 3 have a further improvement in curative effect, indicating that the traditional Chinese medicine fumigation method of the present invention directly acts on the perineum, and the active ingredients of the medicine directly reach the affected part through odor secretion and take effect quickly, which is different from the traditional method. Compared with traditional oral therapy, it has the advantages of quick effect and large amount of medicine directly reaching the affected area. The efficacy of treatment group 3 has been further improved, indicating that the combination of drug fumigation therapy and meridian acupoint magnetic therapy massage can achieve better therapeutic effect. Treatment groups 4 and 5 illustrate that the medicine of the present invention can achieve the best curative effect when it is taken orally and combined with medicine fumigation.
在治疗前后患者体重、心率、血压均未见明显改变。治疗组在整个治疗过程中未发现过敏等明显的不良事件，治疗组痊愈患者随访6个月无一例复发。由此说明本发明治疗盆腔炎疗效确切，安全性高，复发率低，可作为子宫肌瘤首选的治疗药物。There was no significant change in the patient's body weight, heart rate, and blood pressure before and after treatment. In the treatment group, no obvious adverse events such as allergies were found during the whole treatment process, and there was no case of recurrence in the 6-month follow-up of the cured patients in the treatment group. This shows that the present invention has definite curative effect for treating pelvic inflammatory disease, high safety and low recurrence rate, and can be used as the first-selected therapeutic drug for uterine fibroids.
2.盆腔炎治疗临床试验2. Clinical trials on the treatment of pelvic inflammatory disease
设6组治疗组，每组病患50例，每组从治疗之日起10天为一个疗程，三个疗程为观察期，观察期到后在医进行妇科检查，判断疗效。治疗组1，服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用；治疗组2使用实施例2所述中药护垫，将护垫贴于内裤上会阴部相对应的位置，每日更换一次；治疗组3使用实施例3所述内裤，每日替换一次；治疗组4服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用，同时配合使用实施例2所述中药护垫，将护垫贴于内裤上会阴部相对应的位置，每日更换一次；治疗组5服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用，同时配合使用实施例3所述内裤，每日替换一次；治疗组6采用常规治疗药，按成药说明坚持用药。There are 6 treatment groups, 50 patients in each group, 10 days from the day of treatment for each group as a course of treatment, and three courses of treatment as the observation period, after the observation period, a gynecological examination will be carried out in the doctor to judge the curative effect. Treatment group 1 took the traditional Chinese medicine described in Example 1, twice a day, decocted in water, one dose a day, and took it twice in the morning and evening; Treatment group 2 used the traditional Chinese medicine pad described in Example 2, and stuck the pad on the The position corresponding to the perineum on the underpants was replaced once a day; the treatment group 3 used the underpants described in Example 3 and was replaced once a day; the treatment group 4 took the traditional Chinese medicine described in Example 1, twice a day, decocted in water, One dose a day, take it twice in the morning and evening, and use the traditional Chinese medicine pad described in Example 2 at the same time, stick the pad on the corresponding position of the perineum on the underwear, and replace it once a day; Said traditional Chinese medicine, 2 times a day, decocted in water, one dose a day, take twice in the morning and evening, and use the underpants described in Example 3 at the same time, replace once a day; treatment group 6 adopts conventional therapeutic medicine, adhere to the instructions of the patented medicine medication.
具体疗效见表5所示。The specific curative effect is shown in Table 5.
表5.疗效对比Table 5. Comparison of efficacy
由表5数据可以看出，本发明所述中药组合物、护垫和内裤对盆腔炎具有较好的疗效。治疗组4和5说明本发明药物口服再配合药物熏蒸可达到最佳的疗效。在治疗前后患者体重、心率、血压均未见明显改变。治疗组在整个治疗过程中未发现过敏等明显的不良事件，治疗组痊愈患者随访6个月无一例复发。由此说明本发明治疗盆腔炎疗效确切，安全性高，复发率低，可作为盆腔炎首选的治疗药物。As can be seen from the data in Table 5, the traditional Chinese medicine composition, panty liner and underpants of the present invention have a better curative effect on pelvic inflammatory disease. Treatment groups 4 and 5 illustrate that the medicine of the present invention can achieve the best curative effect when it is taken orally and combined with medicine fumigation. There was no significant change in the patient's body weight, heart rate, and blood pressure before and after treatment. In the treatment group, no obvious adverse events such as allergies were found during the whole treatment process, and there was no case of recurrence in the 6-month follow-up of the cured patients in the treatment group. This shows that the present invention has definite curative effect for treating pelvic inflammatory disease, high safety and low recurrence rate, and can be used as the first-selected therapeutic drug for pelvic inflammatory disease.
3.卵巢囊肿治疗临床试验3. Clinical trials on the treatment of ovarian cysts
设6组治疗组，每组病患50例，每组从治疗之日起10天为一个疗程，三个疗程为观察期，观察期到后在医进行B超检查，判断疗效。治疗组1，服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用；治疗组2使用实施例2所述中药护垫，将护垫贴于内裤上会阴部相对应的位置，每日更换一次；治疗组3使用实施例3所述内裤，每日替换一次；治疗组4服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用，同时配合使用实施例2所述中药护垫，将护垫贴于内裤上会阴部相对应的位置，每日更换一次；治疗组5服用实施例1所述中药，每日2次，水煎服，一日一剂，分早晚两次服用，同时配合使用实施例3所述内裤，每日替换一次；治疗组6采用常规治疗药，按成药说明坚持用药。There are 6 treatment groups, 50 patients in each group, 10 days from the day of treatment for each group as a course of treatment, and three courses of treatment as an observation period. After the observation period, B-ultrasound examination will be performed in the hospital to judge the curative effect. Treatment group 1 took the traditional Chinese medicine described in Example 1, twice a day, decocted in water, one dose a day, and took it twice in the morning and evening; Treatment group 2 used the traditional Chinese medicine pad described in Example 2, and stuck the pad on the The position corresponding to the perineum on the underpants was replaced once a day; the treatment group 3 used the underpants described in Example 3 and was replaced once a day; the treatment group 4 took the traditional Chinese medicine described in Example 1, twice a day, decocted in water, One dose a day, take it twice in the morning and evening, and use the traditional Chinese medicine pad described in Example 2 at the same time, stick the pad on the corresponding position of the perineum on the underwear, and replace it once a day; Said traditional Chinese medicine, 2 times a day, decocted in water, one dose a day, take twice in the morning and evening, and use the underpants described in Example 3 at the same time, replace once a day; treatment group 6 adopts conventional therapeutic medicine, adhere to the instructions of the patented medicine Medication.
疗效评价标准：1)治愈：治疗后所有症状全部消失，经B超检查后发现卵巢内囊肿完全消失；2)显效：治疗后症状均明显好转，经B超检查后发现卵巢内囊肿体积减少60％以上；3)有效：治疗后症状好转，B超显示囊肿体积减少20％～60％；4)无效：治疗后症状未见改善。Efficacy evaluation criteria: 1) Cured: all symptoms disappeared after treatment, and intra-ovarian cysts were found to disappear completely after B-ultrasound examination; 2) Significant effect: After treatment, the symptoms were significantly improved, and the volume of intra-ovarian cysts was found to be reduced by 60% after B-ultrasound examination % or more; 3) effective: the symptoms improved after treatment, and B-ultrasound showed that the volume of the cyst decreased by 20% to 60%; 4) invalid: the symptoms did not improve after treatment.
具体疗效见表6所示。The specific curative effect is shown in Table 6.
表6.疗效对比Table 6. Comparison of efficacy
由表6数据可以看出，本发明所述中药组合物、护垫和内裤对卵巢内囊肿都具有较好的疗效。治疗组4和5说明本发明药物口服再配合药物熏蒸可达到最佳的疗效。在治疗前后体重、心率、血压均未见明显改变。治疗组在整个治疗过程中未发现过敏等明显的不良事件，治疗组痊愈患者随访6个月无一例复发。由此说明本发明治疗卵巢囊肿疗效确切，安全性高，复发率低，可作为卵巢囊肿首选的治疗药物。As can be seen from the data in Table 6, the traditional Chinese medicine composition, panty liner and underpants of the present invention all have good curative effects on ovarian cysts. Treatment groups 4 and 5 illustrate that the medicine of the present invention can achieve the best curative effect when it is taken orally and combined with medicine fumigation. There was no significant change in body weight, heart rate, and blood pressure before and after treatment. In the treatment group, no obvious adverse events such as allergies were found during the whole treatment process, and there was no case of recurrence in the 6-month follow-up of the cured patients in the treatment group. This shows that the present invention has definite curative effect for treating ovarian cysts, high safety and low recurrence rate, and can be used as the first-selected treatment drug for ovarian cysts.
Claims (10)
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