CN105853614A - Gynaecological capsule - Google Patents
Gynaecological capsule Download PDFInfo
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- CN105853614A CN105853614A CN201610162776.2A CN201610162776A CN105853614A CN 105853614 A CN105853614 A CN 105853614A CN 201610162776 A CN201610162776 A CN 201610162776A CN 105853614 A CN105853614 A CN 105853614A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention relates to a gynaecological capsule. The gynaecological capsule comprises 5 to 15 parts of saffron extract, 5 to 10 parts of propolis extract, 5 to 10 parts of lithospermum extract, 10 to 20 parts of a cucumber cell stock solution, 5 to 10 parts of chitosan, 3 to 5 parts of vitamin E, 80 to 120 parts of plant germ essential oil, 3 to 5 parts of betaine and 3 to 5 parts of soya bean lecithin. The capsule is prepared from saffron, propolis, lithospermum, cucumber, plant germs and other natural raw materials through superfine grinding, dynamic ultrasonic extraction, supercritical CO2 separation and extraction, macroporous resin column chromatography, separation via an acoustic film separator, etc. The capsule prepared in the invention can repair vagina mucosa, moisten and restore vaginal wall cells and recover elasticity of vagina, has bacteriostatic, bactericidal and antiviral effect and can be used for treating a variety of vaginal, uterine and pelvic inflammatory diseases; and through long-term usage of the capsule, fitness of the uterus and the ovary can be kept, and arrival of climacterium can be delayed.
Description
Technical field
The present invention relates to a kind of gynecological capsule, in particular to one contain Stigma Croci extract, propolis extract,
Radix Arnebiae extract, Fructus Cucumidis sativi cell stock solution, chitosan, vitamin E, plant embryo quintessence oil, glycine betaine and soybean lecithin
There is the gynecological's capsule repairing vaginal mucosa effect.
Background technology
The physiological structure feature of vagina determines its infection being highly susceptible to exogenous virus and pathogen bacteria, with
Be suffering from gynaecologic vaginal disease in various degree to a lot of women, as vulvitis, cervicitis, bacterial vaginosis and
Mycotic, trichomonas and nonspecific vaginitis etc..Nearly ten years gynaecologic vaginal disease have become as serious harm women be good for
The commonly encountered diseases of health and frequently-occurring disease, according to the relevent statistics, the patient's number suffering from gynaecologic vaginal disease the most in the world occupies women
More than the 40% of year population, women uses gynecologic medicine the most for each person every year more than 5-8 time, and affects women many
Among healthy gynecological diseases, the vagina caused because gynecological is unclean is again the one that women's diseases occurrence frequency is the highest
Disease, is also the first big disease of harm women's health, for relevant on this in recent years market female health, medicine of keeping a public place clean
Usage amount is also increasing year by year.
Gynaecologic vaginal disease is the vaginal cell mucosa that women is caused infection to cause by the factor such as exogenous virus, pathogen bacteria
Tissue-damaging disease, owing to vagina epithelial tissue cells is the cell that a class has secretion capacity, it has point
Secrete many merits such as self-cleaning thing, secretion estrogen, secretion endocrine hormone, secretory immune composition and secretion lubricating fluid
Can, but in the past while treating this type of disease, often due to the medicine used has certain zest, cause the moon
The destruction of road mucomembranous cell secretory function so that women occur too early dry and astringent, vaginal cell secretory function decline, sexual life
Difficulty, occurs menopause phenomenon too early.
The medicine that gynaecologic vaginal disease is kept a public place clean, keeps healthy and prevented and treated in this area for gynaecologic vaginal at present is many, especially
It is that some Chinese and western medicine preparations also form the most original curative effect advantage in clinical practice, but due to gynaecologic vaginal disease
Sickness rate is high and pathomechanism is complex, more existing pharmaceutical preparatioies still can not fully meet in terms of curative effect clinical and
The needs in market, though some chemical drugs has antiinflammatory, antibacterial action, but do not account for alleviating vaginal mucosa cell thorn
The problem swashing property, thus it substantially has zest side effect to vaginal mucosa cell；Although some lotions and emulsion agent are clear
Clean vagina, but life-time service also can rinse out vaginal mucosa cell secreta in a large number, not only causes gynecological dry and astringent existing
As, simultaneously because the protection vagina losing mucosal secretions the most more easily causes bacterial infection and virus；It addition, at medicine
Dosage form aspect, in addition to lotion and emulsion agent, at present both at home and abroad to the drug main tablet to be had of gynaecologic vaginal disease treatment, hard
Capsule, suppository, tablet, hard capsule, suppository drug are impure higher, and vaginal mucosa emiocytosis function is broken by its impurity
Bad huge.
The present invention is compared with existing patented technology, and employing pure natural substance is raw material, nontoxic non-stimulated, has no side effect,
Can not only effectively repair vaginal mucosa, have antiinflammatory, antibiotic effect simultaneously, life-time service can maintain uterus, ovary,
Postpone involutional arrival.
Summary of the invention
One aspect of the present invention provides a kind of gynecological capsule, it is possible to effectively repair vaginal mucosa, moistens and repairs vaginal wall cell,
Recover vagina elastic, there is antiinflammatory, antibiotic effect, it is possible to for various vaginas, uterus, pelvic inflammation simultaneously.
Concrete, described gynecological capsule contains Stigma Croci extract 5-15 part, propolis extract 5-10 part, Radix Arnebiae (Radix Lithospermi) carry
Take thing 5-10 part, Fructus Cucumidis sativi cell stock solution 10-20 part, chitosan 5-10 part, vitamin E 3-5 part, plant embryo essence
Oil 80-120 part, glycine betaine 3-5 part and soybean lecithin 3-5 part.
In one specific embodiment of the present invention, described gynecological's capsule contains Stigma Croci extract 15 parts, propolis
Extract 10 parts, Radix Arnebiae extract 10 parts, Fructus Cucumidis sativi cell stock solution 20 parts, chitosan 10 parts, vitamin E 5 parts,
Plant embryo quintessence oil 120 parts, glycine betaine 5 parts and soybean lecithin 5 parts.
In one specific embodiment of the present invention, described gynecological's capsule contains Stigma Croci extract 5 parts, propolis
Extract 5 parts, Radix Arnebiae extract 5 parts, Fructus Cucumidis sativi cell stock solution 10 parts, chitosan 5 parts, vitamin E 3 parts, plant
Plumule quintessence oil 80 parts, glycine betaine 3 parts and soybean lecithin 3 parts.
In one specific embodiment of the present invention, described gynecological's capsule contains Stigma Croci extract 10 parts, propolis
Extract 8 parts, Radix Arnebiae extract 8 parts, Fructus Cucumidis sativi cell stock solution 15 parts, chitosan 6 parts, vitamin E 4 parts, plant
Plumule quintessence oil 100 parts, glycine betaine 4 parts and soybean lecithin 4 parts.
In a specific embodiment of the present invention, plant embryo quintessence oil is Semen Tritici aestivi germ oil.
Stigma Croci extract, propolis extract, Radix Arnebiae extract, Fructus Cucumidis sativi cell stock solution, chitosan, dimension life in the present invention
Element E and Semen Tritici aestivi germ oil, glycine betaine and soybean lecithin all can use commercially available prod, or use this area routine side
Prepared by formula.
One of the present invention preferred embodiment in, the preparation of Stigma Croci extract comprises the steps: Stigma Croci
Medical material carries out micronizing to particle diameter 80-120 μm, is placed in dynamic ultrasound extraction pot, adds the 70-80% of 5-10 times amount
Ethanol solution, at 50-80 DEG C extract 30～50min, filter, obtain extracting solution；By extracting solution, filter, concentrate,
By AB-8 macroporous adsorptive resins, use 20-30% ethanol elution 3-5 column volume, discard eluent, then use
70-80% ethanol elution, collects eluent, filters, and concentrates, and is dried, obtains Stigma Croci extract.
One of the present invention preferred embodiment in, the preparation of propolis extract comprises the steps: propolis low
Carry out micronizing under temperature and use supercritical CO to particle diameter 80-120 μm, the propolis powder of gained2Extraction, described supercritical CO2
The technical parameter of extraction is: extraction temperature is 15-25 DEG C, and extracting pressure is 15-25MPa, regulates CO2Flow velocity is
10-14L/h, keeps the pressure and temperature of extraction kettle, extracts 1.5-2.5h, obtains propolis extract.
One of the present invention preferred embodiment in, the preparation of Radix Arnebiae extract comprises the steps: Radix Arnebiae (Radix Lithospermi) medical material
Middle addition accounts for extracts in the ethanol solution of the 85% of gross weight 8-15 times amount 2-3 time, each 2-3 hour, filters, merging
Filtrate, reclaims ethanol, and the extractum that relative density is 1.15-1.25 when concentrating the filtrate to 60 DEG C dry, pulverize,
Obtain Radix Arnebiae extract.
One of the present invention preferred embodiment in, the preparation method of Fructus Cucumidis sativi cell stock solution includes slightly cutting fresh cucumber
Water heavy with 0.2～0.3 times afterwards mixes, and ultrasonic cell-break machine put into by mixed liquor, is broken into cell serosity, cell
Serosity, after centrifuge processes, is taken supernatant and is separated by Acoustic membrane separator, obtain molecular weight and be less than
The Fructus Cucumidis sativi cell stock solution of 6000D.
Another aspect of the present invention, be to provide a kind of described in there is the preparation of the gynecological's capsule repairing vaginal mucosa effect
Method, comprises the steps:
(1) Stigma Croci extract, propolis extract, Radix Arnebiae extract, Fructus Cucumidis sativi cell stock solution are prepared respectively；
(2) various raw material is taken according to formula: Stigma Croci extract 5-15 part, propolis extract 5-10 part, Radix Arnebiae (Radix Lithospermi) are extracted
Thing 5-10 part, Fructus Cucumidis sativi cell stock solution 10-20 part, chitosan 5-10 part, vitamin E 3-5 part, plant embryo quintessence oil
80-120 part, glycine betaine 3-5 part and soybean lecithin 3-5 part；
(3), after plant embryo quintessence oil being heated to 50-60 DEG C, Stigma Croci extract, propolis extract, Radix Arnebiae (Radix Lithospermi) are extracted
Thing, Fructus Cucumidis sativi cell stock solution, chitosan, vitamin E, glycine betaine and soybean lecithin are dissolved in plant embryo quintessence oil, mixed
Close in proportion liquid is placed in high speed centrifuge under low temperature (4 DEG C) and carry out high speed frozen centrifugation, centrifugation time 15 minutes, rotating speed
3500rpm, discards residue, retains supernatant；Supernatant is separated by Acoustic membrane separator, obtains molecular weight less than 10000D
Separation liquid；Finally separation liquid is made soft capsule according to this area usual manner, capsule every capacity 0.50ml, i.e.
Obtain finished product；Also can directly by above-mentioned separation liquid directly as external medicinal liquid.
Capsule of the present invention result through clinical usage shows, has the advantage that
One, capsule of the present invention is prone to by mucocutaneous absorption, without chemical synthetic drug and anaphylactogen material, right
Vaginal mucosa cell nonirritant, does not the most produce side effect effect, to human body to the metabolic capacity of vaginal mucosa cell tissue
Nontoxic, there is no any side effect yet.
Two, capsule of the present invention is used alone as gynecological's product of keeping a public place clean, have removing vagina abnormal flavour and antibacterial, sterilization,
The effect of antiviral, has treatment cervical erosion, vaginitis, the effect of pelvic inflammatory disease.
Three, capsule of the present invention has reparation vaginal mucosa and promotes the secretory function of vaginal mucosa cell, simultaneously for woman
In section vagina patient because of use that chemical drugs or other therapeutic pharmaceuticals occur dry and astringent, discomfort, juice under
Fall person has elimination and the function recovered.
Four, medicine Trauma skin of the present invention such as scalds, comedo, flat especially, wound etc. also has and preferably treats work
With.
Five, the statutory regulations of external preparation for skin drug standard requirement, this product during medicine of the present invention meets China national pharmacopeia
Administering mode be vagina administration, quantity is generally first use one, as treatment gynaecologic vaginal disease time every day
Use one, until rehabilitation；Within when using as gynaecologic vaginal health care 3 to 5 days, use once, there is the merit of yin nourishing
Effect, can play moist vaginal mucosal tissue cell, increase vaginal lubrication sense, eliminate the effects such as dry and astringent phenomenon；As gynecological
Use of keeping a public place clean uses 2-3 time for one week, can pre-bacteriological protection, viral infection, and can play antibacterial, sterilize, keep vagina
Interior environment cleaning health etc. act on.
Six, for suffering from the patient of serious gynaecologic vaginal disease when using medicine of the present invention, suitable escalated dose uses
Treatment time can be shortened.
Seven, to the middle-aged and elderly people person that occurs vaginal dryness, use one can increase lubrication sense before sexual life, improve sexual life
Quality of life.
Detailed description of the invention
The present invention can be conducted further description by the following examples, but, the scope of the present invention is not limited to
Following embodiment.One of skill in the art, can it can be appreciated that on the premise of without departing substantially from the spirit and scope of the present invention
So that the present invention is carried out various change and modification.The present invention to test used in material and test method carry out one
As property and/or concrete description.Although being that this area is public by realizing many materials that the object of the invention used and operational approach
Know, but the present invention still makees the most detailed description at this.
The present invention is further illustrated by concrete example, it should be understood, however, that, these examples are only used for more detailed
Carefully specifically describe and be used, and be not to be construed as limiting in any form the present invention.
The present invention to test used in material and test method carry out generality and/or concrete description.Although it is
Realize many materials that the object of the invention used and operational approach is to it is known in the art that but the present invention still makees at this
Describe in detail as far as possible.It will be apparent to those skilled in the art that hereinafter, if not specified, material therefor of the present invention
It is well known in the art with operational approach.
Embodiment 1: prepare capsule as follows:
(1) Stigma Croci extract, propolis extract, Radix Arnebiae extract, Fructus Cucumidis sativi cell stock solution are prepared respectively；
The preparation of Stigma Croci extract comprises the steps: to carry out Stigma Croci medical material micronizing to particle diameter 80-120 μm,
Be placed in dynamic ultrasound extraction pot, add the ethanol solution of 70-80% of 5-10 times amount, extract at 50-80 DEG C 30～
50min, filters, obtains extracting solution；By extracting solution, filter, concentrate, by AB-8 macroporous adsorptive resins, use 20-30%
Ethanol elution 3-5 column volume, discards eluent, then uses 70-80% ethanol elution, collects eluent, filters, dense
Contracting, is dried, obtains Stigma Croci extract；
The preparation of propolis extract comprises the steps: to carry out propolis at low temperatures micronizing to particle diameter 80-120 μm,
The propolis powder of gained uses supercritical CO2Extraction, described supercritical CO2The technical parameter of extraction is: extraction temperature is
15-25 DEG C, extracting pressure is 15-25MPa, regulates CO2Flow velocity is 10-14L/h, keeps pressure and the temperature of extraction kettle
Degree, extracts 1.5-2.5h, obtains propolis extract.
The preparation of Radix Arnebiae extract comprises the steps: the second that will add account for gross weight 8-15 times amount 85% in Radix Arnebiae (Radix Lithospermi) medical material
Alcoholic solution extracts 2-3 time, each 2-3 hour, filter, merging filtrate, reclaim ethanol, concentrate the filtrate to 60 DEG C
Time the extractum that relative density is 1.15-1.25, dry, pulverize, obtain Radix Arnebiae extract.
The preparation method of Fructus Cucumidis sativi cell stock solution includes that fresh cucumber is slightly cut the rear water heavy with 0.2～0.3 times to be mixed, mixed liquor
Putting into ultrasonic cell-break machine, be broken into cell serosity, cell serosity, after centrifuge processes, takes supernatant
Liquid is separated by Acoustic membrane separator again, obtains the molecular weight Fructus Cucumidis sativi cell stock solution less than 6000D.
(2) various raw material is taken according to formula: Stigma Croci extract 15 parts, propolis extract 10 parts, Radix Arnebiae extract 10
Part, Fructus Cucumidis sativi cell stock solution 20 parts, chitosan 10 parts, vitamin E 5 parts, Semen Tritici aestivi germ oil 120 parts, glycine betaine 5
Part and soybean lecithin 5 parts；
(3), after plant embryo quintessence oil being heated to 50-60 DEG C, Stigma Croci extract, propolis extract, Radix Arnebiae (Radix Lithospermi) are extracted
Thing, Fructus Cucumidis sativi cell stock solution, chitosan, vitamin E, glycine betaine and soybean lecithin are dissolved in Semen Tritici aestivi germ oil, mixing
Proportion liquid carries out high speed frozen centrifugation, centrifugation time 15 minutes, rotating speed in being placed in high speed centrifuge under low temperature (4 DEG C)
3500rpm, discards residue, retains supernatant；Supernatant is separated by Acoustic membrane separator, obtains molecular weight and is less than
The separation liquid of 10000D；Finally separation liquid is made soft capsule, capsule every capacity according to this area usual manner
0.50ml, gets product.
Embodiment 2:
Composition of raw materials: Stigma Croci extract 5 parts, propolis extract 5 parts, Radix Arnebiae extract 5 parts, Fructus Cucumidis sativi cell stock solution
10 parts, chitosan 5 parts, vitamin E 3 parts, Semen Tritici aestivi germ oil 80 parts, glycine betaine 3 parts and soybean lecithin 3 parts；
Other are with embodiment 1.
Embodiment 3:
Composition of raw materials: Stigma Croci extract 10 parts, propolis extract 8 parts, Radix Arnebiae extract 8 parts, Fructus Cucumidis sativi cell stock solution
15 parts, chitosan 6 parts, vitamin E 4 parts, Semen Tritici aestivi germ oil 100 parts, glycine betaine 4 parts and soybean lecithin 4 parts；
Other are with embodiment 1.
Comparative example 1:
Composition of raw materials: propolis extract 10 parts, Radix Arnebiae extract 10 parts, Fructus Cucumidis sativi cell stock solution 20 parts, chitosan 10
Part, vitamin E 5 parts, Semen Tritici aestivi germ oil 120 parts, glycine betaine 5 parts and soybean lecithin 5 parts；Other are with embodiment 1.
Comparative example 2:
Composition of raw materials: Stigma Croci extract 15 parts, propolis extract 10 parts, Radix Arnebiae extract 10 parts, chitosan 10
Part, vitamin E 5 parts, Semen Tritici aestivi germ oil 120 parts, glycine betaine 5 parts and soybean lecithin 5 parts；Other are with embodiment 1.
Comparative example 3:
Composition of raw materials: Stigma Croci extract 15 parts, propolis extract 10 parts, Radix Arnebiae extract 10 parts, Fructus Cucumidis sativi cell are former
Liquid 20 parts, vitamin E 5 parts, Semen Tritici aestivi germ oil 120 parts, glycine betaine 5 parts and soybean lecithin 5 parts；Other are with real
Execute example 1.
Comparative example 4:
Composition of raw materials: Stigma Croci extract 15 parts, propolis extract 10 parts, Radix Arnebiae extract 10 parts, Fructus Cucumidis sativi cell are former
Liquid 20 parts, chitosan 10 parts, vitamin E 5 parts, soybean oil 120 parts, glycine betaine 5 parts and soybean lecithin 5 parts；
Other are with embodiment 1.
Comparative example 5:
Composition of raw materials: Stigma Croci extract 15 parts, propolis extract 10 parts, Radix Arnebiae extract 10 parts, Fructus Cucumidis sativi cell are former
Liquid 20 parts, chitosan 10 parts, vitamin E 5 parts, Semen Tritici aestivi germ oil 120 parts, glycine betaine 5 parts；Other are with implementing
Example 1.
The impact of embodiment 4 xylol of the present invention induced mice ear swelling
The white mice depilatory taking 60 body weight 25g ± 2g sloughs back wool, clear water clearing skin surface, and rest 24h,
It is uniformly divided into 6 groups at random, blank group, positive controls, embodiment 1 group and comparative example 1-3 group, administration group
Every day dermal application equivalent medicinal liquid, blank group smears the Semen Tritici aestivi germ oil of equivalent, and positive controls smears JIEERYIN
Washing liquid once a day, successive administration 3 days.After last is administered, 60min, each treated animal dimethylbenzene 50ul are applied to a mice left side
Auricle two sides causes inflammation, cuts ears after causing scorching 30min, and hammer takes ears same area auricle, weighs, and calculates swelling suppression
Rate:
Swelling=cause inflammation sheet heavy-non-induced inflammation of picking up the ears is picked up the ears tablet weight
Inhibitory rate of intumesce=(blank group swelling-administration group swelling)/matched group swelling
The impact of table 1 xylol induced mice ear swelling
The data of table 1 show, medicine of the present invention has significant antiinflammatory action, and each component is the most collaborative；Contrast
After example 1-3 eliminates Stigma Croci extract, Fructus Cucumidis sativi cell stock solution and chitosan respectively, antiphlogistic effects is remarkably decreased.
Embodiment 5 present invention is to experimental animal Tests For Irritating Effects
Experimental animal: SD rat, female, regular grade, 30, body weight 230 grams-250 grams, random point 5 groups, the present invention is real
Execute example 1-3 group and comparative example 4-5 group, often group 6.
Test method: respectively medicinal liquid prepared by embodiment 1-3 and comparative example 4-5 is put animal intravaginal, contact 4 with vaginal mucosa
Hour.Put to death animal in 24 hours, take out topical vaginal tissue, observe with or without congested, edema phenomenon.Result of the test is shown in
Table 2.
Table 2 present invention is to experimental animal Tests For Irritating Effects
| Erythema | Edema | |
| Embodiment 1 | Have no | Have no |
| Embodiment 2 | Have no | Have no |
| Embodiment 3 | Have no | Have no |
| Comparative example 4 | Have no | Slight edema |
| Comparative example 5 | Slight erythema | Have no |
The result of table 2 shows, the present invention is non-stimulated to vaginal mucosa, and replaces Semen Tritici aestivi germ oil and deletion with soybean oil
After soybean lecithin, vaginal mucosa can be produced and stimulate.
Claims (7)
1. gynecological's capsule, containing Stigma Croci extract 5-15 part, propolis extract 5-10 part, Radix Arnebiae extract
5-10 part, Fructus Cucumidis sativi cell stock solution 10-20 part, chitosan 5-10 part, vitamin E 3-5 part, plant embryo quintessence oil 80-120
Part, glycine betaine 3-5 part and soybean lecithin 3-5 part.
2. the gynecological's capsule described in claim 1, wherein plant embryo quintessence oil is Semen Tritici aestivi germ oil.
3. the gynecological's capsule described in claim 1, containing Stigma Croci extract 15 parts, propolis extract 10 parts, purple
Grass extract 10 parts, Fructus Cucumidis sativi cell stock solution 20 parts, chitosan 10 parts, vitamin E 5 parts, plant embryo quintessence oil 120
Part, glycine betaine 5 parts and soybean lecithin 5 parts.
4. the gynecological's capsule described in claim 1, containing Stigma Croci extract 5 parts, propolis extract 5 parts, Radix Arnebiae (Radix Lithospermi)
Extract 5 parts, Fructus Cucumidis sativi cell stock solution 10 parts, chitosan 5 parts, vitamin E 3 parts, plant embryo quintessence oil 80 parts,
Glycine betaine 3 parts and soybean lecithin 3 parts.
5. the gynecological's capsule described in claim 1, containing Stigma Croci extract 10 parts, propolis extract 8 parts, purple
Grass extract 8 parts, Fructus Cucumidis sativi cell stock solution 15 parts, chitosan 6 parts, vitamin E 4 parts, plant embryo quintessence oil 100 parts,
Glycine betaine 4 parts and soybean lecithin 4 parts.
6. the preparation method of the gynecological's capsule described in any one of claim 1-5: comprise the steps: that (1) is according to joining
Side takes various raw material；(2) after plant embryo quintessence oil being heated to 50-60 DEG C, by Stigma Croci extract, propolis extract,
Radix Arnebiae extract, Fructus Cucumidis sativi cell stock solution, chitosan, vitamin E, glycine betaine and soybean lecithin are dissolved in plant embryo essence
In oil, mix liquid carries out high speed frozen centrifugation, centrifugation time 15 points in being placed in high speed centrifuge under low temperature (4 DEG C)
Clock, rotating speed 3500rpm, discard residue, retain supernatant；Supernatant is separated by Acoustic membrane separator, obtains molecular weight little
Separation liquid in 10000D；Finally separation liquid is made soft capsule, capsule every capacity according to this area usual manner
0.50ml, gets product.
7. the application in preparing medicine of the gynecological's capsule described in any one of claim 1-5, it is characterised in that be used for making
Standby treatment cervical erosion, vaginitis, the medicine of pelvic inflammatory disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610162776.2A CN105853614A (en) | 2016-03-21 | 2016-03-21 | Gynaecological capsule |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610162776.2A CN105853614A (en) | 2016-03-21 | 2016-03-21 | Gynaecological capsule |
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| Publication Number | Publication Date |
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| CN105853614A true CN105853614A (en) | 2016-08-17 |
Family
ID=56625318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610162776.2A Pending CN105853614A (en) | 2016-03-21 | 2016-03-21 | Gynaecological capsule |
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| CN (1) | CN105853614A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822392A (en) * | 2017-01-20 | 2017-06-13 | 成都信息工程大学 | A kind of safflower vaginal plugging medicine and its tamping and preparation method |
| CN107456509A (en) * | 2017-08-30 | 2017-12-12 | 海南鸿昇生物药械有限公司 | A kind of external application biological agent and preparation method for vagina prevention, health care and treatment gynaecology genital inflammation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600378A (en) * | 2004-10-15 | 2005-03-30 | 凌沛学 | Lubricant for human body containing extract product form soybean and hyaluronic acid and preparation method |
| CN101095895A (en) * | 2007-07-06 | 2008-01-02 | 韦建学 | Externally-used medicament for the sanitation and health-care of female vagina and for treating gynecology vagina diseases and method for making the same |
| CN103041111A (en) * | 2012-12-20 | 2013-04-17 | 李建萍 | Gynaecological perineum care solution and preparation method thereof |
-
2016
- 2016-03-21 CN CN201610162776.2A patent/CN105853614A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600378A (en) * | 2004-10-15 | 2005-03-30 | 凌沛学 | Lubricant for human body containing extract product form soybean and hyaluronic acid and preparation method |
| CN101095895A (en) * | 2007-07-06 | 2008-01-02 | 韦建学 | Externally-used medicament for the sanitation and health-care of female vagina and for treating gynecology vagina diseases and method for making the same |
| CN103041111A (en) * | 2012-12-20 | 2013-04-17 | 李建萍 | Gynaecological perineum care solution and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 邓历萍等: "壳聚糖宫颈抗菌膜C型治疗宫颈上皮内瘤样变的临床观察", 《中国当代医药》 * |
| 邱立军等: "甜菜碱杀灭微生物效果及毒性的试验观察", 《中国消毒学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822392A (en) * | 2017-01-20 | 2017-06-13 | 成都信息工程大学 | A kind of safflower vaginal plugging medicine and its tamping and preparation method |
| CN107456509A (en) * | 2017-08-30 | 2017-12-12 | 海南鸿昇生物药械有限公司 | A kind of external application biological agent and preparation method for vagina prevention, health care and treatment gynaecology genital inflammation |
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