CN106822392A - A kind of safflower vaginal plugging medicine and its tamping and preparation method - Google Patents
A kind of safflower vaginal plugging medicine and its tamping and preparation method Download PDFInfo
- Publication number
- CN106822392A CN106822392A CN201710048242.1A CN201710048242A CN106822392A CN 106822392 A CN106822392 A CN 106822392A CN 201710048242 A CN201710048242 A CN 201710048242A CN 106822392 A CN106822392 A CN 106822392A
- Authority
- CN
- China
- Prior art keywords
- safflower
- medicine
- tamping
- vaginal plugging
- shitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of safflower intravaginal drug and its tamping and preparation method, is related to intravaginal drug field.Intravaginal drug mainly includes safflower, shitosan, three kinds of compositions of chitosan oligosaccharide, and used as tamping, it also includes the sterilization sliver as intravaginal drug carrier.Wherein, the preparation of intravaginal drug includes extracting in safflower containing including the extract solution of crocetin, safranal, crocin and Picrocrocin composition；Shitosan, chitosan oligosaccharide are added in extract solution and are well mixed, and stirred to thick, obtain vaginal plugging medicine；The preparation of intravaginal drug tamping also includes immersing vaginal plugging medicine on the sliver sterilized, and the space of sliver is full of vaginal plugging agent；The sliver for immersing vaginal plugging medicine is aseptically carried out into anti-oxidation packaging, absence of vagina tamping is obtained.The vaginal plugging agent good antimicrobial effect of the application, improvement colpitis, and do not result in reverse infection.
Description
Technical field
The present invention relates to a kind of medicine and its tamping, more particularly to a kind of safflower intravaginal drug and its tamping.
Technical background
Bacterial vaginosis, beads coccus vaginal disease, trichomonas vaginal disease, cervical erosion are common multiple gynaecology
Disease.It is mostly antibiotics in the medicament for being used in treatment chronic cervicitis, the medicine of colpitis at present, it is long
Time, using can not only cause certain injury to body, while body can produce drug resistance, influences the performance and treatment of drug effect
Effect.
Traditional gynaecology's product is mainly washing lotion, tablet, suppository, gel, effervescent tablet, it is difficult to when effectively achieving sterilization
Between, sterilized position, commonly using antibiotic, lotion, suppository, gel, destroy the pH value of vagina, change the weak acid of vagina
Environment, moreover it is possible to bring the bacterium of introitus into vagina depths, causes reverse infection, triggers gynaecological imflammation.
The content of the invention
For the drug effect for solving prior art presence is not good, gynaecology's product therapeutic effect is poor or produces the technology of reverse infection to ask
Topic, the present invention provides a kind of good drug efficacy, and the good vaginal plugging medicine of therapeutic effect and vaginal plugging agent.
In order to realize the purpose of the present invention, first aspect present invention provides a kind of safflower vaginal plugging medicine, and it has
Safflower, shitosan, chitosan oligosaccharide composition.
Wherein, the safflower, shitosan, chitosan oligosaccharide parts by weights meter, its ratio are 0.8-1.2: 6-8: 1-3.
Preferably, the safflower, shitosan, chitosan oligosaccharide parts by weights meter, its ratio are 0.9-1.1: 6.5-7.5:
1.5-2.5。
It is further preferred that the safflower, shitosan, chitosan oligosaccharide parts by weights meter, its ratio is 1: 7: 3.
Wherein, the active ingredient of the safflower is crocetin, safranal, crocin and Picrocrocin.
To realize the purpose of the present invention, second aspect present invention provides a kind of preparation side of safflower vaginal plugging medicine
Method, comprise the following steps：
Containing in extraction safflower includes the extraction of crocetin, safranal, crocin and Picrocrocin composition
Liquid；
Shitosan, chitosan oligosaccharide are added in extract solution and are well mixed, and stirred to thick, obtain vaginal plugging medicine
Thing.
Wherein, it is described extraction safflower in containing include crocetin, safranal, crocin and Picrocrocin into
Point extract solution be to carry out normal temperature extraction by the way that safflower is put into distilled water, through multiple times of filtration after, what is be mixed to get is multiple
After filtrate, crocus sativus are obtained.
Wherein, the normal temperature extraction is ultrasonic separation.
Wherein, the supersonic frequency of the ultrasonic separation is 25-60kHz, and power density is 2.0-3.0W/cm3；Medicinal material is molten
Liquor ratio takes 1: 10-1: 16；Extraction time is 20-30min；Solvent temperature is 20-50 DEG C.
To realize the purpose of the present invention, third aspect present invention provides a kind of safflower intravaginal drug tamping, and it is by the
On the one hand the vaginal plugging medicine described in and the aseptic cotton composition as pharmaceutical carrier.
To realize the purpose of the present invention, fourth aspect present invention provides a kind of preparation side of safflower intravaginal drug tamping
Method, including：
It is crocetin, safranal, crocin and Picrocrocin composition to contain active ingredient in extraction safflower
Extract solution；
Shitosan, chitosan oligosaccharide are added in extract solution and are well mixed, and stirred to thick, obtain vaginal plugging medicine
Thing；
On the sliver that vaginal plugging medicine immersion has been sterilized, the space of sliver is set to be full of vaginal plugging agent；
The sliver for immersing vaginal plugging medicine is aseptically carried out into anti-oxidation packaging, absence of vagina tamping is obtained.
Wherein, the safflower, shitosan, chitosan oligosaccharide parts by weights meter, its ratio are 0.8-1.2: 6-8: 1-3.
Preferably, the safflower, shitosan, chitosan oligosaccharide parts by weights meter, its ratio are 0.9-1.1: 6.5-7.5:
1.5-2.5。
It is further preferred that the safflower, shitosan, chitosan oligosaccharide parts by weights meter, its ratio is 1: 7: 3.
Wherein, it is described extraction safflower in containing include crocetin, safranal, crocin and Picrocrocin into
Point extract solution be to carry out normal temperature extraction by the way that safflower is put into distilled water, through multiple times of filtration after, what is be mixed to get is multiple
Filtrate obtains.
Wherein, it is described extraction safflower in containing include crocetin, safranal, crocin and Picrocrocin into
The extract solution for dividing can also be obtained after ultrasonic separation treatment.
Wherein, the supersonic frequency that obtains of the ultrasonic separation treatment is 25-60kHz, and power density is 2.0-3.0W/cm3；
Medicinal material solution ratio takes 1: 10-16；Extraction time is 20-30min；Solvent temperature is 20-50 DEG C.
To realize the purpose of the present invention, fifth aspect present invention provides a kind of safflower vagina medicine by described in the third aspect
Thing tamping is applied to the antibacterial purposes of vagina.
To realize the purpose of the present invention, sixth aspect present invention provides a kind of safflower vagina medicine by described in the third aspect
Thing tamping is applied to the purposes of menstruation regulating.
To realize the purpose of the present invention, seventh aspect present invention provides the safflower vagina described in a kind of just third aspect
Medicine tamping is applied to suppress the purposes of tumour cell
It (is that crocetin and two molecule gentiobioses are combined into that the main component of safflower crude drug has crocin
Ester), and containing crocetin dinethyl ester, Picrocrocin, (the predominantly safranal of volatile oil 0.4~1.3%.Safranal system
Picrocrocin hydrolysis generation.Crocin and Picrocrocin may be combined into protocrocin and be stored in crude drug, and
Containing abundant vitamin B2.) bulb contain glucose, amino acid, saponin.
The extract of safflower can suppress the growth of human tumor cells.Wherein the composition with stronger active anticancer is
Crocetin, safranal, crocin and Picrocrocin etc..To blood cell, papillary carcinoma, pinacocyte knurl and soft tissue
Sarcoma etc. is with stronger inhibitory action.Its anticancer mechanism is to suppress DNA and the RNA synthesis of cancer cell, suppresses cell protein and swashs
The activity of enzyme and the expression of proto-oncogene, the formation of tumour is suppressed from molecular level.In addition, safflower has menstruation regulating, work
Blood, dissolving stasis, analgesic, for removing heat from the liver, blood stasis stasis, irregular menstruation, prolonged lochia, traumatic injury, interior external hemorrhage, lung
Inflammation, physical decline, the first body-building efficacy of training.
Product of the shitosan (chitosan) by chitin (Chitin) after deacetylated, also known as chitosan, chemistry
Entitled Chitosan (1-4) -2- amino-B-D glucose.Natural polymer, its have biological functionality and compatibility,
Blood compatibility, security, microbic resolvability etc..In addition shitosan can suppress the growth of some fungies, bacterium and virus
Breeding；In serum, the degradable absorption of shitosan, it also has the effect for promoting blood clotting, therefore is filled out as vagina
Suppository can effectively suppress the growth and breeding of fungi, bacterium and virus, promote blood clotting.
Chitosan oligosaccharide is made up of shitosan depolymerization, is chitin, the upgrading products of shitosan product, can not with shitosan
The superiority of analogy.Chitosan oligosaccharide can be directly dissolved in water, and water solubility is more than 99%, and human absorptivity 99.88%, and it exempts from wound
Infected by bacterium, but also wound healing can be promoted with penetration air and moisture, when chitosan oligosaccharide concentration is 2% to golden yellow
The bacteriostasis rate of color staphylococcus and EHEC is 100%.The antibacterial activity of shitosan is slightly better than chitosan oligosaccharide.But shitosan
Biological absorption only has 1~5%, and chitosan oligosaccharide absorptivity is almost close to 100%.Chitosan oligosaccharide molecular weight is low, good water solubility, function
The advantage such as effect is big, be easily absorbed by the body, bioactivity is high.
Therefore safflower, shitosan and chitosan oligosaccharide are mixed the application the fungistatic effect of obtained vaginal plugging agent
Good, improvement colpitis, and do not result in reverse infection.
Specific embodiment
In order to be more clearly understood that the above objects, features and advantages of the present invention, with reference to specific embodiment
The present invention is further described in detail.
Many concrete details are elaborated in the following description in order to fully understand the present invention, but, the present invention is also
Can be different from other modes described here using other to implement, therefore, the present invention is not limited to following public specific
The limitation of embodiment.
The preparation of the vaginal plugging medicine of embodiment 1
The safflower clear water that will be gathered uses super ripple separation and Extraction at normal temperatures after cleaning, and obtains crocus sativus, its
In, the operating condition of super ripple separation and Extraction is that supersonic frequency is 25kHz-60kHz；Power density is 2.0-3.0W/cm3；Medicinal material
Solution ratio takes 1: 10-16；Extraction time is 20-30min；Solvent temperature is 20-50 DEG C.
Then shitosan, chitosan oligosaccharide are added in crocus sativus and mix to thick, obtain vaginal plugging medicine
Thing.
Wherein, the safflower, shitosan, chitosan oligosaccharide parts by weights meter, its ratio are 1: 7: 3.
It should be noted that the weight of shitosan can be selected from any proportioning in the range of 0.8-1.2, for example
0.9、0.95、1.0、1.04、1.06、1.1、1.13、1.16、1.19；The weight of chitosan oligosaccharide can be selected from the range of 6-8
Any proportioning, such as 6.2,6.4,6.7,6.9,7.1,7.5,7.9；The weight of safflower can be selected from the range of 1-3
Any proportioning, such as 1.2,1.4,1.6,1.9,2.3,2.6,2.9.
The preparation of the intravaginal drug tamping of embodiment 2
Sliver is carried out disinfection after treatment, vaginal plugging medicine obtained in embodiment 2 is immersed in sterilization sliver, make the moon
The space of road sliver is full of vaginal plugging medicine, finally aseptically carries out anti-oxidation packaging, makes to be soaked with medicine filling medicine
The sliver of thing is stored in inert gas, wherein inert gas can be nitrogen, or other can be as anti-oxidation gas
The inert gas of body.
Test example 1
It is control 1 with the conventional extracting method that decocts, and blank negative control is set, the present invention is respectively adopted and implements 1 and in fact
Apply example 2 and control 1 obtain safflower extract solution be applied to Cervical Cancer HeLa Cells, using 48h after, using mtt assay
Determine growth inhibition ratio, flow cytometer and In situ terminal labeling technology for detection cell cycle, the protein kinase C of Hela cells
(protein kinase C, PKC) determination of activity, so as to compare three kinds of pharmacodynamics differences of extract solution.Result shows that two kinds carry
Taking liquid can suppress the growth of Hela cells, and can significantly reduce S phase cells, restrained effectively protein kinase C
The increase of (protein kinase C, PKC) activity, its inhibition level is respectively 45%, 60% and 66%, it is seen then that the present invention
The antitumor pharmacodynamics that the normal temperature extraction ultrasonic technology of use to safflower extract the safranine flower extract of acquisition is excellent
In routinely decoction extracting method, and use ultrasonic wave extraction better.
Test example 2
1st, patient data
According to the bacterial vaginitis volunteer 200 that clinical symptoms and a full set of inspection of leukorrhea are made a definite diagnosis.
2nd, treatment method
Volunteer is divided into 2 groups, every group of 100 people.First group of (experimental group) volunteer is every night clear with warm water
After washing vagina, intravaginal drug tamping prepared by Example 2 is inside vagina；Second group (control group) uses common vagina medicine
Thing, is used according to an instruction.Every group, continuously using first time check is carried out after two weeks, is checked for the second time after five weeks.Treatment
Period has no adverse reaction.
3rd, efficacy assessment standard
It is effective：Vulva is without itch or burning heat sensation；Leukorrhea has and measures normal, transparent free from extraneous odour once in a while；
Effectively：Vulva is without itch or burning heat sensation；Leukorrhea amount is reduced, and leukorrhea is faint yellow, free from extraneous odour；
It is invalid：Pruritus vulvue, or have burning heat sensation；Leukorrhea amount is more, and leukorrhea is grey or celadon, sticky, there is peculiar smell.
4th, result
Experimental group, effective 46, effective 54, invalid 0, total effective rate 100%；Effective 3 of control group, effective 21
Example, invalid 76, total effective rate 24%.Therefore, the intravaginal drug tamping effect that the present invention is provided is better than commercially available the moon
Tract drug, it is seen that the antibacterial action effect is significant of intravaginal drug tamping of the invention, and without recurrence.
The preferred embodiments of the present invention are the foregoing is only, is not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.It is all within the spirit and principles in the present invention, made any repair
Change, equivalent, improvement etc., should be included in protection scope of the present invention etc.
Claims (10)
1. a kind of safflower vaginal plugging medicine, it is characterised in that it has safflower, shitosan, chitosan oligosaccharide composition.
2. vaginal plugging medicine as claimed in claim 1, it is characterised in that the safflower, shitosan, chitosan oligosaccharide are by weight
Divide meter, its ratio is 0.8-1.2：6-8：1-3.
3. medicine as claimed in claim 2, it is characterised in that the safflower, shitosan, chitosan oligosaccharide by weight, its
Ratio is 0.9-1.1：6.5-7.5：1.5-2.5.
4. the medicine as described in claim 1-3 any one, it is characterised in that the active ingredient of the safflower is safflower
Acid, safranal, crocin and Picrocrocin.
5. a kind of preparation method of vaginal plugging medicine, it is characterised in that comprise the following steps：
Containing in extraction safflower includes the extract solution of crocetin, safranal, crocin and Picrocrocin composition；
Shitosan, chitosan oligosaccharide are added in extract solution and are well mixed, and stirred to thick, obtain vaginal plugging medicine.
6. a kind of safflower intravaginal drug tamping, it is characterised in that including vaginal plugging medicine and work described in claim 1
It is the aseptic cotton of pharmaceutical carrier.
7. a kind of preparation method of safflower intravaginal drug tamping, it is characterised in that including：
Containing in extraction safflower includes the extract solution of crocetin, safranal, crocin and Picrocrocin composition；
Shitosan, chitosan oligosaccharide are added in extract solution and are well mixed, and stirred to thick, obtain vaginal plugging medicine；
On the sliver that vaginal plugging medicine immersion has been sterilized, the space of sliver is set to be full of vaginal plugging agent；
The sliver for immersing vaginal plugging medicine is aseptically carried out into anti-oxidation packaging, absence of vagina tamping is obtained.
8. a kind of intravaginal drug tamping by described in claim 6 is applied to the antibacterial purposes of vagina.
9. a kind of intravaginal drug tamping by described in claim 6 is applied to the purposes of menstruation regulating.
10. a kind of vaginal plugging medicine or vaginal plugging agent by described in claim 1 or 6 is applied to suppress the use of tumour cell
On the way.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710048242.1A CN106822392A (en) | 2017-01-20 | 2017-01-20 | A kind of safflower vaginal plugging medicine and its tamping and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710048242.1A CN106822392A (en) | 2017-01-20 | 2017-01-20 | A kind of safflower vaginal plugging medicine and its tamping and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106822392A true CN106822392A (en) | 2017-06-13 |
Family
ID=59119471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710048242.1A Pending CN106822392A (en) | 2017-01-20 | 2017-01-20 | A kind of safflower vaginal plugging medicine and its tamping and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106822392A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2249611Y (en) * | 1995-01-20 | 1997-03-19 | 王保安 | Chinese medicine cotton suppository |
| CN103908479A (en) * | 2014-04-29 | 2014-07-09 | 安徽徽科生物工程技术有限公司 | Medical hydrogel for treating gynecological diseases or skin diseases and application of medical hydrogel |
| CN105853614A (en) * | 2016-03-21 | 2016-08-17 | 西藏靓帝生物科技有限公司 | Gynaecological capsule |
-
2017
- 2017-01-20 CN CN201710048242.1A patent/CN106822392A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2249611Y (en) * | 1995-01-20 | 1997-03-19 | 王保安 | Chinese medicine cotton suppository |
| CN103908479A (en) * | 2014-04-29 | 2014-07-09 | 安徽徽科生物工程技术有限公司 | Medical hydrogel for treating gynecological diseases or skin diseases and application of medical hydrogel |
| CN105853614A (en) * | 2016-03-21 | 2016-08-17 | 西藏靓帝生物科技有限公司 | Gynaecological capsule |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Pangestuti et al. | Biological activities of carrageenan | |
| CN103083713B (en) | A kind of aseptic polymerization wound-surface cover dressing | |
| CN103316033B (en) | Gel and use thereof | |
| CN104257639B (en) | A kind of liniment for Wound treating and preparation method thereof | |
| CN110248651A (en) | Composition comprising sulfated polysaccharide | |
| CN103301502A (en) | Gynecological medical gel dressing and preparation method thereof | |
| CN105031708B (en) | A kind of wound rapid hemostasis powder and preparation method thereof | |
| CN105797204A (en) | Application of chlorogenic acid in preparing wound dressing | |
| CN106063798B (en) | Oral ulcer treatment patch film and preparation method thereof | |
| CN110269835A (en) | A kind of antibacterial prosthetic gel of carbomer gynaecology and preparation method thereof | |
| CN107184911A (en) | One kind is used to prevent cervical carcinoma and treatment papillomavirus（HPV）Infection and the product and preparation method of colpitis | |
| CN100502894C (en) | Method for preparing medicine of effective parts extracted from myrobalan for treating diseases infected by bacteria or virus | |
| CN104069124B (en) | Compositions and preparation for gynecological infection | |
| CN103301065A (en) | Nasal spray of seaweed extract and preparation method of nasal spray | |
| CN107812179A (en) | A kind of application of reduced glutathione in preparing treatment wound and smearing medicament | |
| CN106822392A (en) | A kind of safflower vaginal plugging medicine and its tamping and preparation method | |
| CN100360141C (en) | Calf-blood deprotein extract gel | |
| CN111905058A (en) | Pharmaceutical composition for skin mucosa nursing and wound repair and preparation method thereof | |
| CN103816110A (en) | Preparation method of drug transdermal absorbent promoting fracture healing | |
| CN107595819A (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| CN107115377A (en) | A kind of kuh-seng medicinal liquor and preparation method thereof | |
| CN103381196A (en) | Composition used for treating cervical erosion and application thereof | |
| CN102949712A (en) | Chinese and western composite medicine for treating neoplastic diseases | |
| CN112472772A (en) | Antibacterial gel and preparation method thereof | |
| CN106474137A (en) | One kind is containing chlorophyllous film for treating oral ulcer and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170613 |
|
| RJ01 | Rejection of invention patent application after publication |