CN105797204A - Application of chlorogenic acid in preparing wound dressing - Google Patents
Application of chlorogenic acid in preparing wound dressing Download PDFInfo
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- CN105797204A CN105797204A CN201610248643.7A CN201610248643A CN105797204A CN 105797204 A CN105797204 A CN 105797204A CN 201610248643 A CN201610248643 A CN 201610248643A CN 105797204 A CN105797204 A CN 105797204A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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Abstract
The invention discloses the application of chlorogenic acid in preparing a wound dressing.The wound dressing is a composition of chlorogenic acid and a dressing, which can be a composition of chlorogenic acid and a dressing sold in the market or reported in literature, or a composition of chlorogenic acid and an in situ gel dressing, or a composition of chlorogenic acid and a film dressing, or a composition of chlorogenic acid and a sponge dressing.Experiments prove that chlorogenic acid can promote wound healing remarkably.
Description
Technical field
The present invention relates to medical field, particularly to the preparation method of a kind of wound dressing compositions.
Background technology
Wound is primarily referred to as mechanical factor and acts on body, causes the destruction organizing normal mechanism and thus causes dysfunction, including contusion injuries, incision, crush injury and burn etc..Repair in trauma not only includes the propagation of cell, differentiation and migration, also covers the formation of dissimilar cell, enzyme and structural protein etc., be one and relate to the multi-disciplinary research fields such as auxology, cytobiology, biomaterial, molecular biology and clinical medicine.
People cause the various damages of human body skin to be inevitable in daily life and work.Add up according to World Health Organization (WHO), the nineteen ninety whole world various wounds lethal number about 5,100,000 people, it is contemplated that the year two thousand twenty can increase to 8,400,000 people.Adding up according to health ministry, within 2005, wound is the 5th cause of the death in China city and rural area, accounts for the 6.17% of total death toll.Therefore, wound is the disease that a class is very important.Wound dressing is able to play temporary protection wound, prevents from polluting, promoting the medical material of healing, uses one of wound dressing effective means being by trauma care.Phase in the time immemorial, people once used the leaf of plant, animal skins, and even sandy soil, snow etc. cover the surface of human body wound, played hemostasis and the effect of protection injury, and this is the dressing of earliest form.In the traditional medicine of China, repair in trauma includes blood circulation promoting and blood stasis dispelling, snuggle up to pus puts on flesh, removing the necrotic tissue and promoting granulation method etc..The antibiotic that chemical preservative, disinfectant and 20th century that 19 century occurred occur, can make wound infection be effectively controlled.
Tradition repair in trauma less demanding, mainly wound surface can be suppressed immediately to worsen, then can repair wound.Along with the progress in epoch, patient is also more and more higher to the requirement of wound repair, not only to improve the speed of wound face healing, preventing from scar, also to reduce pain in agglutination, have no adverse reaction, not affect appearance etc. after healing.Wound dressing is able to play temporary protection wound, prevents from polluting, promoting the material of healing, uses one of wound dressing effective means being by trauma care.
Traditional dressing such as gauze, cotton pad etc. have certain water absorption, can protect wound surface; but in agglutination, it is easily generated tissue adhesion causes secondary injury; wound surface moist environment cannot be kept to cause healing delay, the invasion and attack of pathogen also cannot be stoped to be easily caused traumatic infection delayed healing process.The proposition theoretical along with wet union and development, wound dressing should be able to keep the moist environment of wound surface to write into the industry guide of the wound surface medical supplies that FDA (Food and Drug Adminstration) promulgates, becomes the starting point of development of new wound dressing for wet union.Desirable dressing is able to maintain that one moistening environment of wound surface, has good breathability, it is possible to promote cell proliferation, can discharge rapidly again the exudate of wound surface as the barrier stopping microorganism, simultaneously should be nontoxic, and no antigen is not likely to produce tissue adhesion.
After situ-gel refers to that macromolecular material is administered with solution or semi-solid state, (temperature of agents area, pH value, ionic species and the change such as concentration, illuminance) is stimulated to respond to external world at medicine-feeding part, there is the reversible transition of dispersity or conformation, form semi-solid or solid preparation.Wherein, the physiological compatibility of the responsive to temperature type gel so that variations in temperature to be responded is best.Responsive to temperature type gel preparation (room temperature) before storage and administration exists with liquid or semisolid form, make gel solution condense because temperature raises (body temperature) after topical, form the gel with good adhesiveness and sustained release performance.Prepare the advantages such as relatively simple, physiological compatibility good, dosage is easily controllable and adhesiveness is good owing to responsive to temperature type gel has production, be widely used to novel eye, nose, rectum and injection delivery systems in recent years.
Chlorogenic acid is widely distributed in plant, all have from high dicotyledon to pteridophyta, it is primarily present in Caprifoliaceae Lonicera, Compositae artemisia and Eucommiaceae Cortex Eucommiae platymiscium, the plant that content is higher mainly has Semen Helianthi, cacao bean, coffee bean, Fructus Hippophae and Chinese traditional herbs, such as Flos Lonicerae, the Cortex Eucommiae.Chlorogenic acid chemistry is called 3-O-coffee phthalein quinic acid, and the dissolubility in water is 4%, is soluble in ethanol, acetone, is slightly soluble in ethyl acetate, is insoluble in the lipophylic organic solvents such as chloroform, ether, benzene, is flaxen solid.Have now been found that chlorogenic acid has antibacterial, antiviral, hepatic cholagogic, antitumor, blood pressure lowering, blood fat reducing isoreactivity.
Summary of the invention
The inventors discovered that chlorogenic acid can be remarkably reinforced repair in trauma.Therefore the invention discloses chlorogenic acid application in preparing wound dressing.
Chlorogenic acid of the present invention, its molecular characterization is:
Chlorogenic acid is widely present in each kind of plant, including some Chinese medicine, vegetable, fruit etc..Chlorogenic acid is can be obtained by by conventional extracts active ingredients technology.Purer chlorogenic acid can be obtained after extraction process is optimized, can be used for being processed further of medicine, as prepared into the compositions of various dosage form.A lot of disclosed documents have reported how to extract from plant and have obtained chlorogenic acid, and are purified.The chlorogenic acid raw material that purity is higher it has been commercially available in market.
In the present invention, wound dressing is the compositions of chlorogenic acid and dressing.Dressing does not limit, and is selected from the casting product of market sale, it is possible to selected from the casting product of bibliographical information, it is preferable that from situ-gel dressing, film dressing, sponge dressing, more preferably situ-gel dressing.Therefore, the compositions of Content of Chlorogenic Acid of the present invention and dressing is selected from the compositions of chlorogenic acid and market sale dressing or the compositions of bibliographical information dressing, chlorogenic acid and the compositions of the compositions of situ-gel dressing, chlorogenic acid and film dressing, chlorogenic acid and sponge dressing, it preferably is selected from chlorogenic acid and the compositions of the compositions of the compositions of situ-gel dressing, chlorogenic acid and film dressing, chlorogenic acid and sponge dressing, more preferably from the compositions of chlorogenic acid and situ-gel dressing.
When the compositions that the wound dressing in the present invention is chlorogenic acid and situ-gel dressing, chlorogenic acid solubilized or be suspended in situ-gel dressing.The material of situ-gel dressing is selected from one or more in thermosensitive in situ gel material, pH sensitive in situ gels research material, ionic strength sensitive type situ-gel material；That is, can be alone in these situ-gel dressing wound dressings in the present invention, can also share, preferably by above-mentioned three kinds of situ-gel materials, including thermosensitive in situ gel material, pH sensitive in situ gels research material, ionic strength sensitive type situ-gel material, bi-material therein is respectively combined application or three kinds of material combination application simultaneously.
When thermosensitive in situ gel material refers on or below a certain temperature, in easy fluent solution or dispersion liquid, when material temperature reach under this temperature or on after, in the gel state of difficulty flowing.When pH sensitive in situ gels research material refers on or below a certain pH (or acidity) value, in easy fluent solution or dispersion liquid, when material pH reach under this pH value or on after, in the gel state of difficulty flowing.The character that ionic strength sensitive type situ-gel material refers to material is relevant with environment ionic strength, and the change of ionic strength directly affects material viscosity in the solution, namely forms the degree of gel.Ion is generally Na+、K+、Ca2+、Zn2+。
Thermosensitive in situ gel material in the present invention is selected from poloxamer188 (Poloxamer407, P407), methylcellulose, hypromellose, chitosan derivatives, polylactic acid-polyethylene glycol block copolymer, polylactic-co-glycolic acid-polyethyleneglycol block copolymer, second hydroxy ethyl cellulose, polycaprolactone polyethyleneglycol block copolymer, poly-N-isopropyl acrylamide, it preferably is selected from poloxamer188, methylcellulose, polylactic acid-polyethylene glycol block copolymer, polylactic-co-glycolic acid-polyethyleneglycol block copolymer, polycaprolactone-polyethylene glycol block copolymer, poly-N-isopropyl acrylamide, more preferably from poloxamer188, methylcellulose.
PH sensitive in situ gels research material in the present invention is selected from CAP (CAP), HP-55 (HPMCP), carbomer, chitosan, it is preferable that from CAP, carbomer.Ionic strength sensitive type situ-gel material in the present invention is selected from alginate, gellan gum.
When the compositions that the wound dressing in the present invention is chlorogenic acid and film dressing, chlorogenic acid may be homogenously dispersed in film dressing.The material of the film dressing in the present invention is not particularly limited, as long as chlorogenic acid can be held and to be attached on wound surface just passable, according to practical situation, it may be preferable to self-induced transparency, translucent material, facilitates look at wound healing situation after a procedure.nullThe material of film dressing is selected from chitosan、Gelatin、Hydroxypropyl methyl cellulose、Ethyl cellulose、Casein、Polyacrylic resin、Methacrylic acid copolymer、Methylcellulose、Zein、Carbomer、Lac、Cellulose acetate-phthalate、POLY-karaya、Poloxamer、Pentaerythritol phthalate、Hydrogenated wood rosin glycerol ester、Alginic acid、Propylene glycol alginate、Sodium alginate、Calcium alginate、Potassium alginate、Ammonium alginate、Hydroxypropylmethyl cellulose phthalate、Hydroxypropyl cellulose、Xanthan gum、Agar、Celluloid、Polyethylene Glycol、Polyvinyl alcohol、Polyvinyl alcohol carboxylic butyraldehyde、Polyethylene carboxylic butyraldehyde diethylamine acetate、Polypropylene、Polyisobutylene、Polystyrene、Polrvinyl chloride、Polyamide、Polyvidone、PVP-VA64、Polyvinyl acetate、Polyvinyl acetate phthalate、Ethylene-vinyl acetate copolymer、Dextrin、Cellulose acetate、One cellulose acetate、Cellulose diacetate、Triafol T、Cellulose acetate dibutylamino-hydrox-ypropyl ether，It preferably is selected from chitosan、Gelatin、Sodium carboxymethyl cellulose、Polyvinyl alcohol、Carbomer、Poloxamer、Sodium alginate、Calcium alginate、Hydroxypropyl methyl cellulose，More preferably from chitosan、Gelatin、Sodium carboxymethyl cellulose、Polyvinyl alcohol，Most preferably from chitosan、Calcium alginate.
When the compositions that the wound dressing in the present invention is chlorogenic acid and sponge dressing, chlorogenic acid may be homogenously dispersed in sponge dressing.The material of the sponge dressing in the present invention is not particularly limited, as long as chlorogenic acid can be held and to be attached on wound surface just passable.The material of sponge dressing is selected from sodium alginate, chitosan, gelatin, collagen protein, it is preferable that from sodium alginate, chitosan.
The preparation method of the compositions of chlorogenic acid and situ-gel dressing is referred to pertinent literature and professional technique.Usually, the material of situ-gel dressing is placed in suitable quantity of water or aqueous solution, fully swelling, it is subsequently adding chlorogenic acid, fully dispersed or dissolving, subpackage.As required, situ-gel dressing can add antioxidant, wetting agent, permeation enhancers.
The preparation method of the compositions of chlorogenic acid and film dressing is referred to pertinent literature and professional technique.Usually, the material of film dressing is placed in appropriate solvent, fully swelling.Solvent is selected from water, aqueous solution, ethanol, isopropanol, acetone.Adding chlorogenic acid in above-mentioned material swelling solution, paving is to the platform scribbling oleaginous base, and after naturally drying, according to dosage dicing is standby.Oleaginous base is selected from paraffin, white beeswax, Cera Flava, vaseline, mineral oil.Platform is selected from glass plate, metallic plate, plastic plate.As required, film dressing can add antioxidant, wetting agent, permeation enhancers, plasticizer.Particularly plasticizer, can strengthen the pliability of multifunctional membrane, not easy fracture, breakage.
The preparation method of the compositions of chlorogenic acid and sponge dressing is referred to pertinent literature and professional technique.Usually, the material of sponge dressing is placed in appropriate solvent, fully swelling.Solvent is selected from water, aqueous solution, ethanol, isopropanol, acetone.Above-mentioned material swelling solution adds chlorogenic acid, goes to lyophilization in mould, package spare.As required, sponge dressing can add antioxidant, wetting agent, permeation enhancers, plasticizer.Particularly plasticizer, can strengthen the pliability of sponge, not easy fracture, breakage.
Accompanying drawing explanation
Fig. 1. the compositions Room temperature Mobil state of chlorogenic acid and situ-gel dressing
Fig. 2. the compositions of chlorogenic acid and situ-gel dressing is the gel state of 37 DEG C
Fig. 3. the compositions outward appearance photo of chlorogenic acid and film dressing
Fig. 4. the compositions outward appearance photo of chlorogenic acid and sponge dressing
Fig. 5. the compositions wound healing promoting experiment of chlorogenic acid and situ-gel dressing. administration group and blank dressing group, administration group and blank group carry out the paired t inspection of bilateral, at the 2nd, 4,6,8,10 days, wound area all had significant difference (p < 0.05).
Fig. 6. the compositions bacteriostatic test photo .A. chlorogenic acid of chlorogenic acid and film dressing and the compositions of situ-gel dressing；B. the antibacterial frost of Bang Erkang.
Fig. 7. the outward appearance photo that the compositions treatment of chlorogenic acid and sponge dressing is scalded
Fig. 8. the pathological photograph of the compositions treatment burn of chlorogenic acid and sponge dressing
Detailed description of the invention
The compositions of embodiment 1. chlorogenic acid and gauze
Take 2g chlorogenic acid to be dissolved in 20mL ethanol, be placed in porcelain dish, put into 10 pieces of 20 × 30cm2Double-deck hospital gauze soak, take out rear-mounted dry, obtain the compositions of chlorogenic acid and gauze.
The compositions of embodiment 2. chlorogenic acid and situ-gel dressing
Take appropriate poloxamer188 and PLURONICS F87, the 0.1g gellan gum 50mL that adds water makes it fully be swelled into homogeneous solution (A liquid)；Weigh 0.5g chitosan to be dissolved in 25mL2% acetic acid；Take 2g chlorogenic acid and be dissolved in 5mL ethanol, add (B liquid) in above-mentioned chitosan solution；A liquid and B liquid are mixed, finally adds distilled water to 100mL, the compositions of the chlorogenic acid obtained and situ-gel dressing.In flow regime (Fig. 1) under said composition room temperature, 37 DEG C place 10min gel state (Fig. 2).
The compositions of embodiment 3. chlorogenic acid and film dressing
2g chlorogenic acid is dissolved in the 100mL 2% acetum containing 2% chitosan, adds 2mL PEG400 and 10mL20mg/mLHPMCK4MSolution, pours natural drying in mould into, obtains the compositions of chlorogenic acid and film dressing.Said composition flat appearance, pliability is good, not easy fracture (Fig. 3).
The compositions of embodiment 4. chlorogenic acid and sponge dressing
40mL2% sodium alginate is slowly added to the 40mL2% chitosan mix homogeneously in stirring, add 10mL glyceryl triacetate as plasticizer, add the 5mL alcoholic solution containing 1g chlorogenic acid, stir, it is sub-packed in mould lyophilizing, obtains the compositions of chlorogenic acid and film dressing.Said composition is loose porous, can absorb a large amount of blood (Fig. 4).
The short wound healing test of the compositions of experimental example 1. chlorogenic acid and situ-gel dressing
Test drug: the chlorogenic acid prepared by embodiment 2 and the compositions of situ-gel dressing.
Rat dorsum skin shears is cut the subcircular wound surface of about 1.5cm diameter, measures every rat wound area, be randomly divided into blank group, blank dressing group and administration group.Blank group, without any process, covers with gauze.Blank dressing group is coated with blank dressing at wound, becomes after gel until solution, is coated with gauze and fixes.Blank dressing is prepared according to embodiment 1, but is not added with chlorogenic acid.Administration group is coated with chlorogenic acid and the compositions of situ-gel dressing at wound, becomes after gel until solution, is coated with gauze and fixes.Within 4,10,14,21,35 days, measure the wound area that do not heal upon administration, calculate healing area.It is plotted against time with Rat Wound Healing rate (area/rat that do not heal starts wound area), obtains Rat Wound Healing curve (Fig. 5).Result shows that administration group entirety healing trend is better than blank dressing group and blank group.
The compositions extracorporeal bacteria inhibitor test of experimental example 2. chlorogenic acid and film dressing
Test drug: the chlorogenic acid prepared by embodiment 3 and the compositions of film dressing.
Golden staphylococci liquid is cultivated: takes 5ml culture medium to sterilizing test tubes, draws 10 μ L bacterium solution and add in test tube, 37 DEG C, overnight incubation in 200rpm shaking table.
Cultivating the preparation of gold glucose coccus Nutrient agar: 4g Carnis Bovis seu Bubali cream adds water 1000ml, tepor is dissolved, and is made into meat extract；10g peptone and 5g sodium chloride add in meat extract, adjust pH to 7.5, boil, and add 17.5g agar, heating for dissolving；120 DEG C of autoclaving agar solutions, culture dish 20min.The agar solution of subpackage sterilizing in super-clean bench, after letting cool, seals and is inverted into 4 DEG C of Refrigerator stores.
Bacteriostatic test: take 0.1mL gold glucose coccus drop and be added in flat board, uniform by aseptic triangle rod coating, cover ware lid, dry 5min, the compositions of chlorogenic acid and film dressing is affixed on and hits exactly containing bacterio-agar surface by aseptic nipper, is inverted and is put in 37 DEG C of constant temperature CO2Incubator, cultivates 24h, measures inhibition zone size after taking out.Result shows that In Vitro Bacteriostasis (4.2cm) effect of the compositions of chlorogenic acid and film dressing is better than listing the antibacterial frost of Bang Erkang (3.7cm) (Fig. 6).
The compositions of experimental example 3. chlorogenic acid and sponge dressing is for the experiment of Burns in Rats wound healing
Test drug: the chlorogenic acid prepared by embodiment 4 and the compositions of sponge dressing.
Rat dorsum skin unhairing, water-bath 90 DEG C manufactures the subcircular burn wound of about about 1.5cm diameter at back.Measure every rat wound area, be randomly divided into blank group and administration group.Within 2nd day, when there is more transudate, administration group is coated with the compositions of chlorogenic acid and sponge dressing, and fixes with gauze.Result shows that blank group rat spends acute infection period death owing to failing, all death in 5 days, and administration group rat is spending actute infection after date, wound surface recovers gradually, basic recovery normal (Fig. 7) in 8 days, pathological section displays that epithelial cell proliferation and normal skin restore (Fig. 8).
Claims (10)
1. chlorogenic acid application in preparing wound dressing.
2. wound dressing as claimed in claim 1, is the compositions of chlorogenic acid and dressing.
3. wound dressing as claimed in claim 2, selected from the compositions of chlorogenic acid and market sale dressing or the compositions of bibliographical information dressing, chlorogenic acid and the compositions of the compositions of situ-gel dressing, chlorogenic acid and film dressing, chlorogenic acid and sponge dressing.
4. wound dressing as claimed in claim 2, is chlorogenic acid and the compositions of situ-gel dressing.
5. wound dressing as claimed in claim 4, wherein the material of situ-gel dressing is selected from one or more in thermosensitive in situ gel material, pH sensitive in situ gels research material, ionic strength sensitive type situ-gel material.
6. wound dressing as claimed in claim 5, wherein thermosensitive in situ gel material is selected from poloxamer188, methylcellulose, hypromellose, chitosan derivatives, polylactic acid-polyethylene glycol block copolymer, polylactic-co-glycolic acid-polyethyleneglycol block copolymer, second hydroxy ethyl cellulose, polycaprolactone polyethyleneglycol block copolymer, poly-N-isopropyl acrylamide.
7. wound dressing as claimed in claim 5, wherein pH sensitive in situ gels research material is selected from CAP, HP-55, carbomer, chitosan.
8. wound dressing as claimed in claim 5, wherein ionic strength sensitive type situ-gel material is selected from alginate, gellan gum.
9. wound dressing as claimed in claim 2, it is the compositions of chlorogenic acid and film dressing, and the material of film dressing is selected from chitosan, gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol, carbomer, poloxamer, sodium alginate, calcium alginate, hydroxypropyl methyl cellulose.
10. wound dressing as claimed in claim 2, is the compositions of chlorogenic acid and sponge dressing, and the material of sponge dressing is selected from sodium alginate, chitosan, gelatin, collagen protein.
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| CN201610248643.7A CN105797204A (en) | 2016-04-21 | 2016-04-21 | Application of chlorogenic acid in preparing wound dressing |
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| CN201610248643.7A CN105797204A (en) | 2016-04-21 | 2016-04-21 | Application of chlorogenic acid in preparing wound dressing |
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Cited By (5)
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| CN106832343A (en) * | 2016-12-30 | 2017-06-13 | 大连工业大学 | The preparation method of the gelation fishskin gelatin high based on oxidation polyphenol substance |
| CN109137264A (en) * | 2018-07-07 | 2019-01-04 | 东莞市联洲知识产权运营管理有限公司 | A method of antibacterial medical dressing is prepared using electrostatic spinning |
| CN111686292A (en) * | 2020-06-10 | 2020-09-22 | 深圳大学 | Nano-silver chlorogenic acid composite dressing as well as preparation method and application thereof |
| CN112791229A (en) * | 2021-01-25 | 2021-05-14 | 吉林大学 | A medical dressing containing chlorogenic acid and paeoniflorin and hyaluronic acid hydrogel |
| CN113476611A (en) * | 2021-08-19 | 2021-10-08 | 四川九章生物科技有限公司 | A composition with skin repairing effect |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106832343A (en) * | 2016-12-30 | 2017-06-13 | 大连工业大学 | The preparation method of the gelation fishskin gelatin high based on oxidation polyphenol substance |
| CN109137264A (en) * | 2018-07-07 | 2019-01-04 | 东莞市联洲知识产权运营管理有限公司 | A method of antibacterial medical dressing is prepared using electrostatic spinning |
| CN111686292A (en) * | 2020-06-10 | 2020-09-22 | 深圳大学 | Nano-silver chlorogenic acid composite dressing as well as preparation method and application thereof |
| CN112791229A (en) * | 2021-01-25 | 2021-05-14 | 吉林大学 | A medical dressing containing chlorogenic acid and paeoniflorin and hyaluronic acid hydrogel |
| CN113476611A (en) * | 2021-08-19 | 2021-10-08 | 四川九章生物科技有限公司 | A composition with skin repairing effect |
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