CN110604759A - Rhinitis spray and preparation method thereof - Google Patents

Abstract

The invention relates to a rhinitis spray and a preparation method thereof. The rhinitis spray is prepared by combining daphne concentrate, peppermint oil, borneol and polysorbate-80, so that the medicaments exert respective effects and generate synergistic action mutually, and the sensitivity of a nasal cavity can be quickly and effectively reduced, and the symptoms of nasal obstruction, rhinocnesmus and the like can be relieved.

Description

Rhinitis spray and preparation method thereof

Technical Field

The invention relates to a rhinitis spray and a preparation method thereof.

Background

Rhinitis is acute or chronic inflammation of the nasal mucosa or submucosal tissue caused by viral infection, bacterial infection, irritation by irritants, etc., resulting in damage to the nasal mucosa or submucosal tissue. Rhinitis causes excessive mucus, often resulting in runny nose, nasal obstruction, etc. Sometimes complicated by sinusitis, nasal polyps; chronic nasal obstruction is often evident and can develop as a eustachian tube blockage. The result is hearing loss, which is particularly prevalent in children. There are many kinds of rhinitis symptoms, and the rhinitis symptoms are different according to the kinds of rhinitis. The patient often has symptoms of nasal obstruction, watery nasal discharge, nasal itching, throat discomfort, sneeze, cough and the like.

At present, the common medicines for treating rhinitis in western medicine are oral antihistamine medicines, glucocorticoid inhalation medicines and local antihistamine medicines, but the medicines treat symptoms and do not treat root causes, the problem cannot be solved fundamentally, and the medicines have great harm to the body after long-term administration. Traditional Chinese medicine takes conditioning as a main part and takes a method of dispelling wind, dispersing lung qi, tonifying qi and removing turbidity to condition rhinitis, but the formula is complex, the medicine tastes are many, and the cost is high.

Therefore, people have great demands on the rhinitis spray which is convenient to use, low in price and good in effect, and the inventor successfully develops the rhinitis spray through a large number of research experiments, thereby completing the invention.

Disclosure of Invention

The invention aims to provide a rhinitis spray with small side effect on a body, simple formula, low cost and good effect and a preparation method thereof.

The rhinitis spray is prepared by combining daphne concentrate, peppermint oil, borneol and polysorbate-80, so that the medicaments exert respective effects and generate synergistic action mutually, and the sensitivity of a nasal cavity can be quickly and effectively reduced, and the symptoms of nasal obstruction, rhinocnesmus and the like can be relieved.

The daphne odora is distributed in Heilongjiang, Jilin, inner Mongolia and other places, and has wide sources. The main effective component of the daphne odora is total flavonoids, and the content of the effective component can be improved to the maximum extent by adopting steam distillation and ethanol extraction.

The components of the rhinitis spray are summarized by the inventor through repeated groping, and the dosage of each component has better effect in the following weight.

100 g of daphne, 2 g of peppermint oil, 2 g of borneol and 8010 ml of polysorbate.

The specific preparation method comprises the following steps:

first, prepare material

a. Collecting fructus Daziziphi spinosae, removing impurities, cleaning, slightly drying in the air, cutting into segments, and drying

b. Peppermint oil: measuring by volume

c. Borneol: measuring by volume

d. Polysorbate-80: measuring by volume

II, preparation of

a. Preparing a daphne concentrate: extracting volatile oil from Dazixiang medicinal materials by a steam distillation method for later use; extracting the dregs of a decoction with 80% ethanol, filtering, and concentrating until the relative density is 1.00-1.02 to obtain a daphne aroma concentrated solution for later use;

b. preparing borneol solution: dissolving Borneolum in small amount of ethanol, adding polysorbate-80, mixing and stirring to obtain Borneolum solution;

c. adding the volatile oil, oleum Menthae Dementholatum and Borneolum Syntheticum solution into the concentrated solution of DAZIXIANG, and stirring;

d. standing for 24 hours, and filtering;

e. filling: and filling the filtered mixed solution to obtain the product.

Due to the adoption of the technical scheme, the invention has the beneficial effects that.

Dazixiang: has good anti-inflammatory and antibacterial effects, and can be used as anti-inflammatory agent. Contains multiple active components, contains farrerol with antibacterial activity against Staphylococcus aureus, and also has antibacterial and antifungal effects against syringic acid and vanillic acid, and also has antiseptic and antibacterial effects against anisic acid, and syringic acid with tranquilizing and local anesthetic effects.

Peppermint oil: is volatile aromatic oil obtained by steam distillation of fresh stems and leaves of herba Menthae, and is pungent, cool and nontoxic. The oleum Menthae Dementholatum has algefacient, analgesic, and antipruritic effects. The anti-irritation effect of menthol causes new secretion in nasal cavity, so that thick mucus is easy to be discharged, and the menthol has the effect of treating nasal obstruction.

Borneol: dredging orifices, dispelling stagnated fire, removing nebula, improving eyesight, relieving swelling and pain, inhibiting bacteria, and relieving inflammation. It is indicated for wind stroke, vomiting, coma due to febrile disease, epilepsy due to convulsion, phlegm-phlegm, qi block, deafness, sore throat, aphtha, otitis media, carbuncle, swelling, hemorrhoid, nebula, and enterobiasis. It is used to treat chronic tracheitis, infantile burn, chronic rhinitis, and suppurative otitis media.

Polysorbate-80: is oleate and nonionic surfactant, has strong hydrophilicity and has emulsification effect.

The four raw materials supplement each other, so that the anti-inflammatory and itching relieving effects are enhanced, and the defect of single raw material effect is avoided. The formula is simple and easy to implement, and the rhinitis conditioning effect is good.

The formula combination of the invention is novel and unique, the scientific basis is original, and the anti-inflammation and itching-relieving effects of the functional components are effectively improved. The innovation of the formula combination is not reported in China. Through the combination and advanced process of the raw materials. According to a specific proportion, volatile oil is extracted from the daphne odora so as to improve the content of active ingredients and enhance the efficacy of the product. Has no adverse side effect and low cost, and is suitable for children and pregnant women.

Detailed Description

The present invention will be described in further detail with reference to examples, and the starting materials used in the present invention are commercially available unless otherwise specified.

Example 1:

taking 100kg of rhinitis spray product as an example, the raw materials are prepared according to the following weight: 100Kg of daphne, 2Kg of peppermint oil, 2Kg of borneol and 8010 ml of polysorbate-oil.

The preparation method of the rhinitis spray comprises the following steps:

a. preparing a daphne concentrate: extracting volatile oil from Dazixiang medicinal materials by steam distillation for later use; collecting the distilled water solution in another container. Extracting the residue with 8 times of 80% ethanol for 2 times, each for 2 hr, filtering, mixing filtrates, recovering ethanol from the filtrate, mixing with the above water solution, and concentrating to relative density of 1.01 to obtain Dazixiang concentrated solution 100 kg;

b. preparing borneol solution: dissolving Borneolum in appropriate amount of ethanol, adding polysorbate-80, mixing and stirring to obtain Borneolum solution;

c. adding the volatile oil, oleum Menthae Dementholatum and Borneolum Syntheticum solution into the Dazixiang concentrated solution, and stirring;

d. standing for 24 hours, and filtering;

e. filling: and filling the filtered mixed solution to obtain the product.

The above-mentioned examples were subjected to clinical trial in recent years, and 100 cases were counted, wherein 45 cases were male, 55 cases were female, 10 cases aged 1-20 years, 55 cases aged 21-40 years, and 35 cases aged 40 years or more.

The medicine is applied to all cases to quickly improve nasal obstruction, nasal itching, no sneezing and nasal discharge reduction. Can achieve good curative effect after long-term use.

Case 1:

what the patient has: female, rhinitis attack, the main symptoms are nose itch, nasal discharge with multiple paroxysms, nasal obstruction. The spray can be used for 2-3 times a day, the effect is improved after 7 days, the disease is cured in two weeks, and then the disease does not relapse.

Case 2:

the patient has a certain position: the spray is used for relieving pain for three times, and is taken 3 to 4 times daily. The disease is cured in two weeks, and no relapse is seen.

Case 3:

patient has a certain: the male can be cured 3-4 times a day in three weeks after being sneezed and nasal discharge for more than years, and the male can not relapse.

The foregoing is merely a preferred embodiment of the invention, which is intended to be illustrative and not limiting. It will be understood by those skilled in the art that various changes, modifications and equivalents may be made therein without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (3)

1. The rhinitis spray is prepared by combining daphne seed concentrated solution, peppermint oil, borneol and polysorbate-80.

2. The rhinitis spray according to claim 1, which is prepared from the following materials in parts by weight:

100 g of daphne, 2 g of peppermint oil, 2 g of borneol and 8010 ml of polysorbate-8010 ml are prepared.

3. The process for preparing a rhinitis spray according to claim 1, wherein:

a. preparing a daphne concentrate: extracting volatile oil from Dazixiang medicinal materials by a steam distillation method for later use; extracting the dregs of a decoction with 80% ethanol, filtering, and concentrating until the relative density is 1.00-1.02 to obtain a daphne aroma concentrated solution for later use;

b. preparing borneol solution: dissolving Borneolum in small amount of ethanol, adding polysorbate-80, mixing and stirring to obtain Borneolum solution;

c. adding the volatile oil, oleum Menthae Dementholatum and Borneolum Syntheticum solution into the concentrated solution of DAZIXIANG, and stirring;

d. standing for 24 hours, and filtering;

e. filling: and filling the filtered mixed solution to obtain the product.