CN111214549A - Nasal cavity nursing spray and preparation method thereof - Google Patents

Abstract

The invention provides a nasal cavity nursing spray which is prepared from the following raw materials in parts by weight: 6-8 parts of centipeda minima, 3-5 parts of eucalyptus leaf extract, 2-4 parts of bay leaf extract, 3-5 parts of sandalwood extract, 4-6 parts of magnolia flower, 8-12 parts of menthol, 5-7 parts of plant cellulose, 1-3 parts of radix scutellariae, 6-8 parts of radix sophorae flavescentis, 5-7 parts of agastache rugosus and 1-3 parts of isotonic regulator. The invention not only can inhibit bacteria and diminish inflammation, but also can keep the inner surface of the nasal cavity moist for a long time, is beneficial to human health, has simple preparation process, no pollution and energy conservation, and is suitable for industrial implementation.

Description

Nasal cavity nursing spray and preparation method thereof

Technical Field

The invention relates to the technical field of nasal cavity sprays, in particular to a nasal cavity nursing spray and a preparation method thereof.

Background

Rhinitis, an inflammatory disease of the nasal cavity, is inflammation of the mucous membrane of the nasal cavity caused by viruses, bacteria, allergens, various physicochemical factors and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of the nasal mucosa. Clinical symptoms include nasal obstruction, nasal discharge, hyposmia, headache, dizziness, etc. In addition, rhinitis, an inflammatory disease of the nasal cavity, refers to inflammation of the nasal mucosa and submucosal tissues, which is variously represented. Inflammation of nasal mucosa is generally caused by virus, bacteria, fungi, allergens, various physicochemical factors and systemic lesions. The rhinitis can be divided into a plurality of types according to different division angles, and from the pathological changes of nasal mucosa, the rhinitis comprises chronic simple rhinitis, chronic hypertrophic rhinitis, caseous rhinitis, atrophic rhinitis and the like, and from the aspects of urgency and slowness of onset and length of disease course, the rhinitis can be divided into acute rhinitis and chronic rhinitis. Allergic rhinitis (that is, allergic rhinitis) and rhinitis medicamentosa are the causes of the disease. However, whatever the cause of rhinitis, the main pathological changes are congestion, swelling and exudation of nasal mucosa; hyperplasia, atrophy, or necrosis, etc., wherein viral infection is the primary cause, and secondary bacterial infection is the basis of viral infection, and more than 100 viruses are known to cause the disease, the most common rhinovirus, coronavirus, coxsackie virus, and myxovirus and paramyxovirus, etc. Viral transmission is mainly from breathing to inhalation, and people usually use oral drugs or drug sprays to treat rhinitis, and also use nasal sprays to clean nasal cavities to relieve part of symptoms.

The existing nasal cavity spray is mainly used for sterilization and disinfection, and mainly comprises physiological saline, bactericides such as aspirin, ibuprofen, chlorpheniramine and other antibiotic medicines are added, although the nasal cavity cleaning solution can effectively kill most germs and has a certain sterilization and disinfection effect on nasal cavities, the side effect and the medication hazard degree to human bodies are increased by neglecting the use of medicines and antibiotic medicines for cleaning or sterilizing the nasal cavities, and most products in the market have single effect, the maintenance time for flushing the nasal cavities is short when the nasal cavities are used, some patients with dry, itchy and astringent nose often just spray the nasal cavities soon, the nose recovers the dry and itchy state again, and the use frequency of individual patients is increased due to the need of working or other aspects, so that inconvenience is brought to life, the nasal cavity bearing pressure is increased, and the nasal cavity patients can achieve the expected effect when the products are not used, have to be used continuously, which causes a lot of unnecessary troubles.

Disclosure of Invention

Aiming at the defects, the invention aims to provide a nasal cavity nursing spray and a preparation method thereof, which can inhibit bacteria and diminish inflammation, can keep the inner surface of a nasal cavity moist for a long time, are beneficial to human health, have simple preparation process, are free from pollution, save energy and are suitable for industrial implementation.

The invention is realized by the following technical scheme:

a nasal care spray characterized by: the composition is characterized by comprising the following raw materials in parts by weight: 6-8 parts of centipeda minima, 3-5 parts of eucalyptus leaf extract, 2-4 parts of bay leaf extract, 3-5 parts of sandalwood extract, 4-6 parts of magnolia flower, 8-12 parts of menthol, 5-7 parts of plant cellulose, 1-3 parts of radix scutellariae, 6-8 parts of radix sophorae flavescentis, 5-7 parts of agastache rugosus and 1-3 parts of isotonic regulator.

As an improvement of the technical proposal, the plant cellulose is prepared by smashing wheat bran and inorganic acid into pulp to prepare α -cellulose, then processing the α -cellulose to partially depolymerize the cellulose, and then removing non-crystalline parts and purifying the α -cellulose.

As an improvement of the above technical scheme, the eucalyptus leaf extract, the laurel leaf extract and the sandalwood extract are water saturated solutions prepared by respectively extracting fresh eucalyptus leaves, laurel leaves and sandalwood leaves by a distillation extraction method.

As an improvement of the technical scheme, the preparation method of the nasal cavity care spray comprises the following steps:

step 1: mixing herba Centipedae, flos Magnoliae, Mentholum, plant cellulose, Scutellariae radix, radix Sophorae Flavescentis and herba Agastaches, pulverizing to 40-80 mesh, adding 8-12 times of 85% ethanol, soaking at 55-65 deg.C for 12-24 hr, filtering, and collecting filtrate; reflux-extracting the residue with 6-8 times of 95% ethanol at 65-85 deg.C for 5-7 hr, filtering, mixing filtrates, and concentrating under reduced pressure to 0.2-0.5g/ml to obtain solution A;

step 2: mixing the folium Eucalypti Globueli extractive solution, laurel leaf extractive solution and lignum Santali albi extractive solution at corresponding ratio, shaking at low frequency for 3-5 min, and filtering with filter to obtain solution B;

and step 3: mixing the obtained solution A and solution B, and oscillating at low frequency;

and 4, step 4: placing the isoosmotic adjusting agent into the mixed solution obtained in the step (3), and stirring the mixed solution for 3-5 minutes by using a magnetic stirrer;

and 5: carrying out electrode treatment on the mixed solution obtained in the step 4 every 3 minutes; the electrode treatment is to place the mixed reaction solution in a lower electrode medium of a plasma device with the voltage of 18kV, the current of 1.2mA and the gap of 3 mm;

step 6: and (5) sterilizing the solution obtained in the step (5), and sealing and preserving.

As an improvement of the technical proposal, the solution obtained is irradiated by an ultraviolet light source to kill the microorganisms in the solution.

The invention has the beneficial effects that:

according to the scheme, the type of a bactericide in the nasal spray is changed, the traditional aspirin, ibuprofen, chlorphenamine and other antibiotic medicines are replaced by natural bactericidal and anti-inflammatory substances in plants such as eucalyptus leaves, bay leaves, sandalwood and the like, side effects on a human body are reduced, medicine resistance cannot be generated by bacteria in nasal cavities, a special preparation process is adopted to change the molecular selective permeability of the medicines, so that the spray forms a moisturizing membrane on the inner wall of the nasal cavity, the durability of cleaning and moisturizing the nasal cavity is improved on the premise that nasal germs are eliminated, the nasal cavity is kept clean and moist for a long time, the expected effect of the product is improved, and the pressure of a patient who is troubled to use the nasal spray is relieved better. In addition, the centipeda minima can treat stuffy nose and obstruction, nasosinusitis and watery nasal discharge, the menthol is used as an irritant in medicine and acts on skin or mucous membrane to achieve the effects of cooling and relieving itching, the magnolia flower can treat acute and chronic rhinitis, allergic rhinitis, hypertrophic rhinitis, nasosinusitis, paranasal sinusitis and the like, and the centipeda minima has the advantages of outstanding curative effect, high cure rate, simplicity, low cost and easiness in clinical popularization by matching with other medicinal auxiliary materials.

Detailed Description

Example 1:

a nasal care spray characterized by: the composition is characterized by comprising the following raw materials in parts by weight: 7 parts of centipeda minima, 4 parts of eucalyptus leaf extract, 3 parts of bay leaf extract, 4 parts of sandalwood extract, 5 parts of magnolia flower, 10 parts of menthol, 6 parts of plant cellulose, 2 parts of radix scutellariae, 7 parts of radix sophorae flavescentis, 6 parts of agastache rugosus and 2 parts of an isoosmotic adjusting agent.

wherein the plant cellulose is prepared by mashing wheat bran and inorganic acid into slurry to obtain α -cellulose, treating to partially depolymerize cellulose, removing non-crystalline part, and purifying.

The Eucalyptus leaf extractive solution, the laurel leaf extractive solution and the sandalwood extractive solution are water saturated solutions prepared by respectively extracting fresh Eucalyptus leaf, laurel leaf and sandalwood leaf by a distillation extraction method.

Specifically, the preparation method of the nasal cavity care spray comprises the following steps:

step 1: mixing herba Centipedae, flos Magnoliae, Mentholum, plant cellulose, Scutellariae radix, radix Sophorae Flavescentis and herba Agastaches, pulverizing to 40-80 mesh, adding 8-12 times of 85% ethanol, soaking at 55-65 deg.C for 12-24 hr, filtering, and collecting filtrate; reflux-extracting the residue with 6-8 times of 95% ethanol at 65-85 deg.C for 5-7 hr, filtering, mixing filtrates, and concentrating under reduced pressure to 0.2-0.5g/ml to obtain solution A;

step 2: mixing the folium Eucalypti Globueli extractive solution, laurel leaf extractive solution and lignum Santali albi extractive solution at corresponding ratio, shaking at low frequency for 3-5 min, and filtering with filter to obtain solution B;

and step 3: mixing the obtained solution A and solution B, and oscillating at low frequency;

and 4, step 4: placing the isoosmotic adjusting agent into the mixed solution obtained in the step (3), and stirring the mixed solution for 3-5 minutes by using a magnetic stirrer;

and 5: carrying out electrode treatment on the mixed solution obtained in the step 4 every 3 minutes; the electrode treatment is to place the mixed reaction solution in a lower electrode medium of a plasma device with the voltage of 18kV, the current of 1.2mA and the gap of 3 mm;

step 6: and (5) sterilizing the solution obtained in the step (5), and sealing and preserving.

Finally, the solution is irradiated by an ultraviolet light source, and the microorganisms in the solution are killed.

According to the scheme, the type of a bactericide in the nasal spray is changed, the traditional aspirin, ibuprofen, chlorphenamine and other antibiotic medicines are replaced by natural bactericidal and anti-inflammatory substances in plants such as eucalyptus leaves, bay leaves, sandalwood and the like, side effects on a human body are reduced, medicine resistance cannot be generated by bacteria in nasal cavities, a special preparation process is adopted to change the molecular selective permeability of the medicines, so that the spray forms a moisturizing membrane on the inner wall of the nasal cavity, the durability of cleaning and moisturizing the nasal cavity is improved on the premise that nasal germs are eliminated, the nasal cavity is kept clean and moist for a long time, the expected effect of the product is improved, and the pressure of a patient who is troubled to use the nasal spray is relieved better. In addition, the centipeda minima can treat stuffy nose and obstruction, nasosinusitis and watery nasal discharge, the menthol is used as an irritant in medicine and acts on skin or mucous membrane to achieve the effects of cooling and relieving itching, the magnolia flower can treat acute and chronic rhinitis, allergic rhinitis, hypertrophic rhinitis, nasosinusitis, paranasal sinusitis and the like, and the centipeda minima has the advantages of outstanding curative effect, high cure rate, simplicity, low cost and easiness in clinical popularization by matching with other medicinal auxiliary materials.

Example 2:

a nasal care spray characterized by: the composition is characterized by comprising the following raw materials in parts by weight: 7 parts of centipeda minima, 4 parts of eucalyptus leaf extract, 3 parts of bay leaf extract, 4 parts of sandalwood extract, 5 parts of magnolia flower, 6 parts of plant cellulose, 2 parts of radix scutellariae, 7 parts of radix sophorae flavescentis, 6 parts of wrinkled gianthyssop herb and 2 parts of isotonic regulator.

wherein the plant cellulose is prepared by mashing wheat bran and inorganic acid into slurry to obtain α -cellulose, treating to partially depolymerize cellulose, removing non-crystalline part, and purifying.

The Eucalyptus leaf extractive solution, the laurel leaf extractive solution and the sandalwood extractive solution are water saturated solutions prepared by respectively extracting fresh Eucalyptus leaf, laurel leaf and sandalwood leaf by a distillation extraction method.

Specifically, the preparation method of the nasal cavity care spray comprises the following steps:

step 1: mixing herba Centipedae, flos Magnoliae, plant cellulose, Scutellariae radix, radix Sophorae Flavescentis and herba Agastaches, pulverizing to 40-80 mesh, adding 8-12 times of 85% ethanol, soaking at 55-65 deg.C for 12-24 hr, filtering, and collecting filtrate; reflux-extracting the residue with 6-8 times of 95% ethanol at 65-85 deg.C for 5-7 hr, filtering, mixing filtrates, and concentrating under reduced pressure to 0.2-0.5g/ml to obtain solution A;

step 2: mixing the folium Eucalypti Globueli extractive solution, laurel leaf extractive solution and lignum Santali albi extractive solution at corresponding ratio, shaking at low frequency for 3-5 min, and filtering with filter to obtain solution B;

and step 3: mixing the obtained solution A and solution B, and oscillating at low frequency;

and 4, step 4: placing the isoosmotic adjusting agent into the mixed solution obtained in the step (3), and stirring the mixed solution for 3-5 minutes by using a magnetic stirrer;

and 5: carrying out electrode treatment on the mixed solution obtained in the step 4 every 3 minutes; the electrode treatment is to place the mixed reaction solution in a lower electrode medium of a plasma device with the voltage of 18kV, the current of 1.2mA and the gap of 3 mm;

step 6: and (5) sterilizing the solution obtained in the step (5), and sealing and preserving.

Finally, the solution is irradiated by an ultraviolet light source, and the microorganisms in the solution are killed.

According to the scheme, the type of a bactericide in the nasal spray is changed, the traditional aspirin, ibuprofen, chlorphenamine and other antibiotic medicines are replaced by natural bactericidal and anti-inflammatory substances in plants such as eucalyptus leaves, bay leaves, sandalwood and the like, side effects on a human body are reduced, medicine resistance cannot be generated by bacteria in nasal cavities, a special preparation process is adopted to change the molecular selective permeability of the medicines, so that the spray forms a moisturizing membrane on the inner wall of the nasal cavity, the durability of cleaning and moisturizing the nasal cavity is improved on the premise that nasal germs are eliminated, the nasal cavity is kept clean and moist for a long time, the expected effect of the product is improved, and the pressure of a patient who is troubled to use the nasal spray is relieved better.

Example 3:

a nasal care spray characterized by: the composition is characterized by comprising the following raw materials in parts by weight: 4 parts of eucalyptus leaf extract, 3 parts of laurel leaf extract, 4 parts of sandalwood extract, 5 parts of magnolia flower, 10 parts of menthol, 6 parts of plant cellulose, 2 parts of radix scutellariae, 7 parts of radix sophorae flavescentis, 6 parts of agastache rugosus and 2 parts of an isoosmotic adjusting agent.

wherein the plant cellulose is prepared by mashing wheat bran and inorganic acid into slurry to obtain α -cellulose, treating to partially depolymerize cellulose, removing non-crystalline part, and purifying.

The Eucalyptus leaf extractive solution, the laurel leaf extractive solution and the sandalwood extractive solution are water saturated solutions prepared by respectively extracting fresh Eucalyptus leaf, laurel leaf and sandalwood leaf by a distillation extraction method.

Specifically, the preparation method of the nasal cavity care spray comprises the following steps:

step 1: mixing flos Magnoliae, Mentholum, plant cellulose, Scutellariae radix, radix Sophorae Flavescentis, and herba Agastaches, pulverizing to 40-80 mesh, adding 8-12 times of 85% ethanol, soaking at 55-65 deg.C for 12-24 hr, filtering, and collecting filtrate; reflux-extracting the residue with 6-8 times of 95% ethanol at 65-85 deg.C for 5-7 hr, filtering, mixing filtrates, and concentrating under reduced pressure to 0.2-0.5g/ml to obtain solution A;

step 2: mixing the folium Eucalypti Globueli extractive solution, laurel leaf extractive solution and lignum Santali albi extractive solution at corresponding ratio, shaking at low frequency for 3-5 min, and filtering with filter to obtain solution B;

and step 3: mixing the obtained solution A and solution B, and oscillating at low frequency;

and 4, step 4: placing the isoosmotic adjusting agent into the mixed solution obtained in the step (3), and stirring the mixed solution for 3-5 minutes by using a magnetic stirrer;

and 5: carrying out electrode treatment on the mixed solution obtained in the step 4 every 3 minutes; the electrode treatment is to place the mixed reaction solution in a lower electrode medium of a plasma device with the voltage of 18kV, the current of 1.2mA and the gap of 3 mm;

step 6: and (5) sterilizing the solution obtained in the step (5), and sealing and preserving.

Finally, the solution is irradiated by an ultraviolet light source, and the microorganisms in the solution are killed.

According to the scheme, the type of a bactericide in the nasal spray is changed, the traditional aspirin, ibuprofen, chlorphenamine and other antibiotic medicines are replaced by natural bactericidal and anti-inflammatory substances in plants such as eucalyptus leaves, bay leaves, sandalwood and the like, side effects on a human body are reduced, medicine resistance cannot be generated by bacteria in nasal cavities, a special preparation process is adopted to change the molecular selective permeability of the medicines, so that the spray forms a moisturizing membrane on the inner wall of the nasal cavity, the durability of cleaning and moisturizing the nasal cavity is improved on the premise that nasal germs are eliminated, the nasal cavity is kept clean and moist for a long time, the expected effect of the product is improved, and the pressure of a patient who is troubled to use the nasal spray is relieved better.

Example 4:

a nasal care spray characterized by: the composition is characterized by comprising the following raw materials in parts by weight: 7 parts of centipeda minima, 4 parts of eucalyptus leaf extract, 3 parts of bay leaf extract, 4 parts of sandalwood extract, 5 parts of magnolia flower, 10 parts of menthol, 6 parts of plant cellulose, 2 parts of radix scutellariae, 7 parts of radix sophorae flavescentis, 6 parts of agastache rugosus and 2 parts of an isoosmotic adjusting agent.

wherein the plant cellulose is prepared by mashing wheat bran and inorganic acid into slurry to obtain α -cellulose, treating to partially depolymerize cellulose, removing non-crystalline part, and purifying.

The Eucalyptus leaf extractive solution, the laurel leaf extractive solution and the sandalwood extractive solution are water saturated solutions prepared by respectively extracting fresh Eucalyptus leaf, laurel leaf and sandalwood leaf by a distillation extraction method.

Specifically, the preparation method of the nasal cavity care spray comprises the following steps:

step 1: mixing herba Centipedae, flos Magnoliae, Mentholum, plant cellulose, Scutellariae radix, radix Sophorae Flavescentis and herba Agastaches, pulverizing to 40-80 mesh, adding 8-12 times of 85% ethanol, soaking at 55-65 deg.C for 12-24 hr, filtering, and collecting filtrate; reflux-extracting the residue with 6-8 times of 95% ethanol at 65-85 deg.C for 5-7 hr, filtering, mixing filtrates, and concentrating under reduced pressure to 0.2-0.5g/ml to obtain solution A;

step 2: mixing the folium Eucalypti Globueli extractive solution, laurel leaf extractive solution and lignum Santali albi extractive solution at corresponding ratio, shaking at low frequency for 3-5 min, and filtering with filter to obtain solution B;

and step 3: mixing the obtained solution A and solution B, and oscillating at low frequency;

and 4, step 4: placing the isoosmotic adjusting agent into the mixed solution obtained in the step (3), and stirring the mixed solution for 3-5 minutes by using a magnetic stirrer;

and 5: and (4) sterilizing the solution obtained in the step (4), and sealing and preserving.

Finally, the solution is irradiated by an ultraviolet light source, and the microorganisms in the solution are killed.

The spray prepared in the above example was tested using the following method: opening the dust cover, slightly lifting the head, extending the spray head into one side of the nostril for spraying for 2 times, and inhaling the nursing liquid into the body by inhaling the nasal cavity simultaneously during spraying so as to swallow the nursing liquid; changing the nostril at the other side, and repeating the above application method.

Group of	Time to onset (average)	Smooth duration (average)
			Example 1	At once	Half a day
Example 2	3min	2.2h
			Example 3	3.5min	2.5h
Example 4	5min	30min

In addition, the comparison and the content show that the special preparation process adopted by the invention (wherein the electrode induction treatment is taken as a core technical point, the treatment greatly enhances the molecule selective permeability of the components of the essence with different compositions, so that the components of the essence of the spray are mutually fused and permeated), the components of the essence extracting solution of the spray are easier to permeate into the skin tissues of the nasal cavity, the durability of cleaning and moistening the nasal cavity is improved on the premise that the nasal cavity is cleared of germs of the product, the nasal cavity is kept clean and moist for a long time, the expected effect of the product is improved, the trouble pressure of using the nasal cavity spray by a patient is better relieved, and no side effect is caused.

Claims (5)

1. A nasal care spray characterized by: the composition is characterized by comprising the following raw materials in parts by weight: 6-8 parts of centipeda minima, 3-5 parts of eucalyptus leaf extract, 2-4 parts of bay leaf extract, 3-5 parts of sandalwood extract, 4-6 parts of magnolia flower, 8-12 parts of menthol, 5-7 parts of plant cellulose, 1-3 parts of radix scutellariae, 6-8 parts of radix sophorae flavescentis, 5-7 parts of agastache rugosus and 1-3 parts of isotonic regulator.

2. the nasal cavity care spray according to claim 1, wherein the plant cellulose is prepared by pulping wheat bran and a mineral acid to α -cellulose, partially depolymerizing the cellulose by treatment, removing non-crystalline parts, and purifying.

3. The nasal care spray according to claim 1, characterized in that: the Eucalyptus leaf extractive solution, the laurel leaf extractive solution and the sandalwood extractive solution are water saturated solutions prepared by respectively extracting fresh Eucalyptus leaf, laurel leaf and sandalwood leaf by a distillation extraction method.

4. A method of preparing a nasal care spray according to claims 1-3, characterized in that: the preparation method comprises the following steps:

step 1: mixing herba Centipedae, flos Magnoliae, Mentholum, plant cellulose, Scutellariae radix, radix Sophorae Flavescentis and herba Agastaches, pulverizing to 40-80 mesh, adding 8-12 times of 85% ethanol, soaking at 55-65 deg.C for 12-24 hr, filtering, and collecting filtrate; reflux-extracting the residue with 6-8 times of 95% ethanol at 65-85 deg.C for 5-7 hr, filtering, mixing filtrates, and concentrating under reduced pressure to 0.2-0.5g/ml to obtain solution A;

step 2: mixing the folium Eucalypti Globueli extractive solution, laurel leaf extractive solution and lignum Santali albi extractive solution at corresponding ratio, shaking at low frequency for 3-5 min, and filtering with filter to obtain solution B;

and step 3: mixing the obtained solution A and solution B, and oscillating at low frequency;

and 4, step 4: placing the isoosmotic adjusting agent into the mixed solution obtained in the step (3), and stirring the mixed solution for 3-5 minutes by using a magnetic stirrer;

and 5: carrying out electrode treatment on the mixed solution obtained in the step 4 every 3 minutes; the electrode treatment is to place the mixed reaction solution in a lower electrode medium of a plasma device with the voltage of 18kV, the current of 1.2mA and the gap of 3 mm;

step 6: and (5) sterilizing the solution obtained in the step (5), and sealing and preserving.

5. The nasal care spray according to claim 4, wherein: irradiating the obtained solution with ultraviolet light source to kill microorganisms in the solution.