CN103301254B - Antibacterial liquid used for nasopharyal meatus and preparation method thereof - Google Patents
Antibacterial liquid used for nasopharyal meatus and preparation method thereof Download PDFInfo
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to the technical field of antibacterial liquid, and in particular relates to an antibacterial liquid used for nasopharyal meatus and a preparation method thereof. The antibacterial liquid per liter is prepared from the following raw materials: 1.7 to 1.9g of dialkyl quaternary ammonium salt, 30 to 60ml of glycerinum, 0.1 to 1.3g of menthol, 0.9 to 3.0g of sodium chloride, 5 to 8g of extracts of traditional Chinese medicine, and the balance of purified water. The antibacterial liquid adopts a plurality of raw materials capable of clearing heat, dispelling wind, relieving sore throat, resisting inflammation, resisting bacteria and easing pain; all the raw materials supplement each other and develop the synergism to realize the characteristics of the best antibacterial performance, short treatment course and quick return of the antibacterial liquid. The biocompatibility of the antibacterial liquid meets the requirement of GB/T 16886.11-2011, and the microbiological indicator meets the requirement of GB15979-2002. The antibacterial liquid is applicable to control and nursing of nasal infection, oral infection, throat infection, various acute (chronic) rhinitis, pharyngitis, auditory meatus inflammation, dental ulcer, and skin and mucous membrane wound infection, and can be used for promoting the healing of the wound and reducing the postoperative infection.
Description
Technical field
The present invention relates to antimicrobial fluid technical field, be specifically related to a kind of nasopharynx tract antimicrobial fluid and preparation method thereof.
Background technology
Nasopharyngitis is a kind of common disease in people's daily life.The traditional method for the treatment of nasopharyngitis has medicinal preparation for oral administration, normal saline, nasal drop etc.Medicinal preparation for oral administration curative effect is of short duration slowly, need follow the doctor's advice; Normal saline nasal cavity cleaning need carry out under medical personnel instruct, and curative effect local; Nasal drop is breathed of short duration unobstructed, and life-time service can cause medicamentous rhinitis.
Application number is that the Chinese invention patent of 98114635.X describes a kind of preparation method of Chinese medicine drop for curing rhinitis for the treatment of rhinitis, sinusitis, and it is mixed by Fructus Xanthii, Flos Magnoliae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, borneol, Oleum menthae, Oleum sesami 10 taste Chinese crude drug tortures into drop.
But the Drug therapy fungistatic effect of above-mentioned treatment nasopharyngitis is poor, effectively can not treat nasopharyngitis.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of nasopharynx tract antimicrobial fluid of good antimicrobial effect is provided.
To achieve these goals, the present invention adopts following technical scheme: a kind of nasopharynx tract antimicrobial fluid, and often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.7-1.9g
Glycerol 30-60ml
Menthol 0.1-1.3g
Sodium chloride 0.9-3.0g
Chinese medicine extract 5-8g
Purified water surplus.
Preferably, often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.8-1.9g
Glycerol 40-50ml
Menthol 0.5-1.3g
Sodium chloride 2.0-3.0g
Chinese medicine extract 7-8g
Purified water surplus.
More preferred, often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.8g
Glycerol 40ml
Menthol 0.5g
Sodium chloride 2g
Chinese medicine extract 7g
Purified water surplus.
Preferably, described dialkyl quaternary ammonium salt is didecyl Dimethy ammonium chloride.Dialkyl quaternary ammonium salt molecular band positive charge, can together with bacterial adhesion, and the metabolism of interference antibacterial outer wall, causes bacteria cell wall metabolism disorder, thus cause bacterial death, reach antibacterial object.The chemical stability of the didecyl Dimethy ammonium chloride that the present invention is used is good, has the multiple performances such as softness, sterilization, sterilization, emulsifying.
Menthol described in the present invention is natural menthol, and the traditional Chinese medical science shows that Herba Menthae has dispelling wind, dispels the heat, wards off effect that is dirty, removing toxic substances, and menthol mainly plays and kills anti-inflammation, analgesic effect in the present invention.
In the present invention, sodium chloride plays the effect of sterilization, sterilization.
Glycerol of the present invention is as hygroscopic agent, viscosity modifier, solvent.
Be rich in multiple heat clearing away in Chinese medicine extract of the present invention, dispel the wind, sore-throat relieving, antiinflammatory, antibacterial, analgesic composition.
Preferably, described Chinese medicine extract is extracted by the raw material of following weight portion and forms:
Flos Magnoliae grass 10-30 part
Herba Centipedae 10-30 part
Herba Violae 10-30 part
Flos Lonicerae 10-30 part
Radix Isatidis 10-30 part.
Flos Magnoliae grass has and dispels the wind, and sensible effect, for controlling headache, nasal sinusitis, has a stuffy nose obstructed, toothache.
Herba Centipedae has dispersing wind-cold, clearing the nasal passage, cough-relieving, effect of removing toxic substances, and recording Herba Centipedae in " four tones of standard Chinese pronunciation book on Chinese herbal medicine " can stuffy nose relieving gas, and sharp nine orifices, tells wind-phlegm.
Herba Violae mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Cure mainly that sore throat swells and ache, jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.
Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating, for carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease is generated heat.
Radix Isatidis has effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving.
More preferred, described Chinese medicine extract is extracted by the raw material of following weight portion and forms:
Flos Magnoliae grass 10-20 part
Herba Centipedae 20-30 part
Herba Violae 20-30 part
Flos Lonicerae 10-20 part
Radix Isatidis 10-20 part.
Or described Chinese medicine extract is extracted by the raw material of following weight portion and forms:
Flos Magnoliae grass 20-30 part
Herba Centipedae 10-20 part
Herba Violae 10-20 part
Flos Lonicerae 20-30 part
Radix Isatidis 20-30 part.
Another object of the present invention is to provide a kind of preparation method of nasopharynx tract antimicrobial fluid, and it comprises following preparation process:
The preparation of steps A, Chinese medicine extract: the Flos Magnoliae of above-mentioned formula ratio grass, Herba Centipedae, Herba Violae, Flos Lonicerae, Radix Isatidis are added purified water and refine, crosses leaching filtrate, concentrated, dry, obtain Chinese medicine extract;
Step B, weighing: weigh the dialkyl quaternary ammonium salt of above-mentioned formula ratio, glycerol, menthol, sodium chloride and Chinese medicine extract;
Step C, preparation: load weighted for step B dialkyl quaternary ammonium salt, glycerol, menthol, sodium chloride and Chinese medicine extract are put into container, adds purified water and be settled to 1L;
Step D, filtration: the solution stirring prepared by step C, to evenly, obtains nasopharynx tract antimicrobial fluid after filtration;
Step e, subpackage, ethylene oxide sterilizing.
Preferably, in described steps A the addition of purified water be Flos Magnoliae grass, Herba Centipedae, Herba Violae, Flos Lonicerae, Radix Isatidis cumulative volume 10-15 doubly, the temperature of refinement is 95-98 DEG C, and the time of refinement is 2-4h.
Compared with prior art, beneficial effect is in the present invention:
(1) the present invention adopt dialkyl quaternary ammonium salt, glycerol, menthol, sodium chloride and Chinese medicine extract to be multiplely rich in heat clearing away, dispel the wind, sore-throat relieving, antiinflammatory, antibacterial, analgesia function produce nasopharynx tract antimicrobial fluid, each raw material complements each other, play the synergism between raw material, make to invention achieves heat-clearing and toxic substances removing, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, evacuation of pus granulation promoting, a surname's clearing the nasal passage, pain relieving, hemostasis, antipruritic effect, good effect is served to the treatment of nasopharyngitis.
(2) nasopharynx tract antimicrobial fluid biocompatibility of the present invention meets GB/T 16886.11-2011 requirement, and antimicrobial fluid microbiological indicator meets GB 15979-2002 requirement.
(3) the present invention is applicable to the infection of nasal cavity, oral cavity, throat, the control of various acute and chronic rhinitis, allergic rhinitis, pharyngitis, auditory meatus inflammation, oral ulcer, skin, mucosa traumatic infection and nursing, promotes the healing of wound surface, reduces postoperative infection.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
embodiment 1.
A kind of nasopharynx tract antimicrobial fluid, often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.7g, glycerol 30ml, menthol 0.1g, sodium chloride 0.9g, Chinese medicine extract 5g, purified water surplus.Described dialkyl quaternary ammonium salt is didecyl Dimethy ammonium chloride.Described Chinese medicine extract is extracted by the raw material of following weight portion and forms: Flos Magnoliae grass 10 parts, Herba Centipedae 20 parts, Herba Violae 20 parts, Flos Lonicerae 10 parts, Radix Isatidis 10 parts.
A preparation method for nasopharynx tract antimicrobial fluid, it comprises following preparation process:
The preparation of steps A, Chinese medicine extract: the Flos Magnoliae of above-mentioned formula ratio grass, Herba Centipedae, Herba Violae, Flos Lonicerae, Radix Isatidis are added purified water and refine, the addition of purified water be Flos Magnoliae grass, Herba Centipedae, Herba Violae, Flos Lonicerae, 10 times of Radix Isatidis cumulative volume, the temperature of refining is 95 DEG C, the time of refining is 2h, cross leaching filtrate, concentrated, dry, obtain Chinese medicine extract;
Step B, weighing: weigh the dialkyl quaternary ammonium salt of above-mentioned formula ratio, glycerol, menthol, sodium chloride and Chinese medicine extract;
Step C, preparation: load weighted for step B dialkyl quaternary ammonium salt, glycerol, menthol, sodium chloride and Chinese medicine extract are put into container, adds purified water and be settled to 1L;
Step D, filtration: the solution stirring prepared by step C, to evenly, obtains nasopharynx tract antimicrobial fluid after filtration;
Step e, subpackage, ethylene oxide sterilizing.
embodiment 2.
A kind of nasopharynx tract antimicrobial fluid, often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.8g, glycerol 40ml, menthol 0.5g, sodium chloride 2g, Chinese medicine extract 7g, purified water surplus.Described dialkyl quaternary ammonium salt is didecyl Dimethy ammonium chloride.Described Chinese medicine extract is extracted by the raw material of following weight portion and forms: Flos Magnoliae grass 20 parts, Herba Centipedae 30 parts, Herba Violae 30 parts, Flos Lonicerae 20 parts, Radix Isatidis 20 parts.
A preparation method for nasopharynx tract antimicrobial fluid, it comprises following preparation process:
The preparation of steps A, Chinese medicine extract: the Flos Magnoliae of above-mentioned formula ratio grass, Herba Centipedae, Herba Violae, Flos Lonicerae, Radix Isatidis are added purified water and refine, the addition of purified water be Flos Magnoliae grass, Herba Centipedae, Herba Violae, Flos Lonicerae, 13 times of Radix Isatidis cumulative volume, the temperature of refining is 96 DEG C, the time of refining is 3h, cross leaching filtrate, concentrated, dry, obtain Chinese medicine extract;
Step B, weighing: weigh the dialkyl quaternary ammonium salt of above-mentioned formula ratio, glycerol, menthol, sodium chloride and Chinese medicine extract;
Step C, preparation: load weighted for step B dialkyl quaternary ammonium salt, glycerol, menthol, sodium chloride and Chinese medicine extract are put into container, adds purified water and be settled to 1L;
Step D, filtration: the solution stirring prepared by step C, to evenly, obtains nasopharynx tract antimicrobial fluid after filtration;
Step e, subpackage, ethylene oxide sterilizing.
embodiment 3.
A kind of nasopharynx tract antimicrobial fluid, often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.9g, glycerol 60ml, menthol 1.3g, sodium chloride 3.0g, Chinese medicine extract 8g, purified water surplus.Described dialkyl quaternary ammonium salt is didecyl Dimethy ammonium chloride.Described Chinese medicine extract is extracted by the raw material of following weight portion and forms: Flos Magnoliae grass 20 parts, Herba Centipedae 10 parts, Herba Violae 10 parts, Flos Lonicerae 20 parts, Radix Isatidis 20 parts.
A preparation method for nasopharynx tract antimicrobial fluid, it comprises following preparation process:
The preparation of steps A, Chinese medicine extract: the Flos Magnoliae of above-mentioned formula ratio grass, Herba Centipedae, Herba Violae, Flos Lonicerae, Radix Isatidis are added purified water and refine, the addition of purified water be Flos Magnoliae grass, Herba Centipedae, Herba Violae, Flos Lonicerae, 15 times of Radix Isatidis cumulative volume, the temperature of refining is 98 DEG C, the time of refining is 4h, cross leaching filtrate, concentrated, dry, obtain Chinese medicine extract;
Step B, weighing: weigh the dialkyl quaternary ammonium salt of above-mentioned formula ratio, glycerol, menthol, sodium chloride and Chinese medicine extract;
Step C, preparation: load weighted for step B dialkyl quaternary ammonium salt, glycerol, menthol, sodium chloride and Chinese medicine extract are put into container, adds purified water and be settled to 1L;
Step D, filtration: the solution stirring prepared by step C, to evenly, obtains nasopharynx tract antimicrobial fluid after filtration;
Step e, subpackage, ethylene oxide sterilizing.
embodiment 4.
A kind of nasopharynx tract antimicrobial fluid, often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.9g, glycerol 50ml, menthol 1.1g, sodium chloride 2.5g, Chinese medicine extract 7g, purified water surplus.Described dialkyl quaternary ammonium salt is didecyl Dimethy ammonium chloride.Described Chinese medicine extract is extracted by the raw material of following weight portion and forms: Flos Magnoliae grass 30 parts, Herba Centipedae 20 parts, Herba Violae 20 parts, Flos Lonicerae 30 parts, Radix Isatidis 30 parts.
A preparation method for nasopharynx tract antimicrobial fluid, it comprises following preparation process:
The preparation of steps A, Chinese medicine extract: the Flos Magnoliae of above-mentioned formula ratio grass, Herba Centipedae, Herba Violae, Flos Lonicerae, Radix Isatidis are added purified water and refine, the addition of purified water be Flos Magnoliae grass, Herba Centipedae, Herba Violae, Flos Lonicerae, 12 times of Radix Isatidis cumulative volume, the temperature of refining is 97 DEG C, the time of refining is 4h, cross leaching filtrate, concentrated, dry, obtain Chinese medicine extract;
Step B, weighing: weigh the dialkyl quaternary ammonium salt of above-mentioned formula ratio, glycerol, menthol, sodium chloride and Chinese medicine extract;
Step C, preparation: load weighted for step B dialkyl quaternary ammonium salt, glycerol, menthol, sodium chloride and Chinese medicine extract are put into container, adds purified water and be settled to 1L;
Step D, filtration: the solution stirring prepared by step C, to evenly, obtains nasopharynx tract antimicrobial fluid after filtration;
Step e, subpackage, ethylene oxide sterilizing.
Dongguan hospital department of otorhinolaryngology, applies drop of the present invention treatment rhinitis, in 400 patients for the treatment of, male patient 240 example, female patient 160 example, the age, from 10 years old to 72 years old, carries out follow-up investigation to this 400 routine patient, cure 340 examples, cure rate reaches 85%, and the continuous drop 3-4 days of patient with slight symptoms takes effect, and within one week, takes a turn for the better, recovery from illness in 20 days, the recovery from illness in 30 days of the continuous drop of patient with severe symptoms.
Case 1.
Zeng, female 26 years old, suffers from chronic rhinitis, there are nasal obstruction, headache, dizziness, suppurating property nasal mucus, every 3-5 minute takes out and groans nose once, has had a strong impact on its work and has chosen spouse, through repeatedly treating all to no effect, the drop of the embodiment of the present invention 1 is adopted to drip 10 days (every day puts 3 times, and each 3-5 that drips drips), various transference cure, recovery from illness, follows up a case by regular visits to 2 years without recurrence.
Case 2.
Xue, man, 15 years old, have a headache without olfactory sensation, hypomnesis, suppurating property nasal mucus, had a strong impact on school grade, within 3 days, headache syndromes disappears completely, and nasal cavity is unobstructed, (every day puts 3 times to adopt the drop of the embodiment of the present invention 2 to drip 8 days, each 3-5 that drips drips) afterwards without purulence nasal mucus, have olfactory sensation, after again drop within 5 days, (every day puts 2 times, each 3-5 that drips drips) drug withdrawal, without recurrence in 2 years.
Case 3.
Lee, female, 45 years old, suffers from nasopharyngitis 6 years, and nasopharynx is dry uncomfortable, has the not easily expectoration of thickness sample secretions, and time serious, meeting hoarseness, pharyngalgia, headache, dizziness, check visible mucosa chronic congestion, and hypertrophy is plump, coated with secretions or dry crusts.Repeatedly treat to lose and be clearly better, drip 2 weeks rear (every day puts 3 times, and each 3-5 that drips drips) with the drop that the embodiment of the present invention 3 is obtained, symptom alleviates greatly, and (every day puts 2 times, drips a 3-5 at every turn and drips) recovery from illness in 10 days is dripped in continuation, nothing recurrence in 2 years.
Case 4.
Zhang, man 72 years old, suffer from chronic rhinitis, sinusitis 17 years, once did puncture antral drainage, nearly 2 years recurrent exerbation again, severe headache, suppurating property nasal mucus, frowziness.Check find bilateral nasal decongestion, swelling, in nodositas, nasal cavity has purulent secretion, adopts the drop of the embodiment of the present invention 4 to drip 10 days (every day puts 3 times, and each 3-5 that drips drips), recovery from illness, so far no recurrence.
Finally should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention; but not limiting the scope of the invention; although done to explain to the present invention with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify to technical scheme of the present invention or equivalent replacement, and not depart from essence and the scope of technical solution of the present invention.
Claims (8)
1. a nasopharynx tract antimicrobial fluid, is characterized in that: often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.7-1.9g
Glycerol 30-60ml
Menthol 0.1-1.3g
Sodium chloride 0.9-3.0g
Chinese medicine extract 5-8g
Purified water surplus,
Described Chinese medicine extract is extracted by the raw material of following weight portion and forms:
Flos Magnoliae 10-30 part
Herba Centipedae 10-30 part
Herba Violae 10-30 part
Flos Lonicerae 10-30 part
Radix Isatidis 10-30 part.
2. a kind of nasopharynx tract antimicrobial fluid according to claim 1, is characterized in that: often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.8-1.9g
Glycerol 40-50ml
Menthol 0.5-1.3g
Sodium chloride 2.0-3.0g
Chinese medicine extract 7-8g
Purified water surplus.
3. a kind of nasopharynx tract antimicrobial fluid according to claim 1, is characterized in that: often liter of antimicrobial fluid is made up of following raw material:
Dialkyl quaternary ammonium salt 1.8g
Glycerol 40ml
Menthol 0.5g
Sodium chloride 2g
Chinese medicine extract 7g
Purified water surplus.
4. a kind of nasopharynx tract antimicrobial fluid according to claim 1, is characterized in that: described dialkyl quaternary ammonium salt is didecyl Dimethy ammonium chloride.
5. a kind of nasopharynx tract antimicrobial fluid according to claim 1, is characterized in that: described Chinese medicine extract is extracted by the raw material of following weight portion and forms:
Flos Magnoliae 10-20 part
Herba Centipedae 20-30 part
Herba Violae 20-30 part
Flos Lonicerae 10-20 part
Radix Isatidis 10-20 part.
6. a kind of nasopharynx tract antimicrobial fluid according to claim 1, is characterized in that: described Chinese medicine extract is extracted by the raw material of following weight portion and forms:
Flos Magnoliae 20-30 part
Herba Centipedae 10-20 part
Herba Violae 10-20 part
Flos Lonicerae 20-30 part
Radix Isatidis 20-30 part.
7. the preparation method of a kind of nasopharynx tract antimicrobial fluid according to claim 1, is characterized in that: it comprises following preparation process:
The preparation of steps A, Chinese medicine extract: the Flos Magnoliae of above-mentioned formula ratio, Herba Centipedae, Herba Violae, Flos Lonicerae, Radix Isatidis are added purified water and refine, crosses leaching filtrate, concentrated, dry, obtain Chinese medicine extract;
Step B, weighing: weigh the dialkyl quaternary ammonium salt of above-mentioned formula ratio, glycerol, menthol, sodium chloride and Chinese medicine extract;
Step C, preparation: load weighted for step B dialkyl quaternary ammonium salt, glycerol, menthol, sodium chloride and Chinese medicine extract are put into container, adds purified water and be settled to 1L;
Step D, filtration: the solution stirring prepared by step C, to evenly, is filtered;
Step e, subpackage, ethylene oxide sterilizing, obtains nasopharynx tract antimicrobial fluid.
8. the preparation method of a kind of nasopharynx tract antimicrobial fluid according to claim 7, it is characterized in that: in described steps A the addition of purified water be Flos Magnoliae, Herba Centipedae, Herba Violae, Flos Lonicerae, Radix Isatidis cumulative volume 10-15 doubly, the temperature of refining is 95-98 DEG C, and the time of refinement is 2-4h.
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| CN108567947A (en) * | 2018-08-01 | 2018-09-25 | 赵敏 | The nasal cavity cleaning liquid being applicable in after swimming |
| CN110054993B (en) * | 2019-04-04 | 2021-02-26 | 筑迹(深圳)创新健康科技有限公司 | Long-life organic silicon polymer antibacterial liquid, preparation method thereof and preparation method of antibacterial coating |
| CN116747253A (en) * | 2023-06-28 | 2023-09-15 | 河北康灵医药科技有限公司 | Skin mucosa antibacterial lotion for ear, nose and throat and preparation method thereof |
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Application publication date: 20130918 Assignee: GUANGXI DAQING BIOLOGICAL SCIENCE & TECHNOLOGY CO.,LTD. Assignor: GUANGXI XINYE BIOLOGICAL TECHNOLOGY Co.,Ltd. Contract record no.: X2023980043782 Denomination of invention: An antibacterial solution for the nasopharynx cavity and its preparation method Granted publication date: 20150225 License type: Common License Record date: 20231018 |