CN110946816A - Natural herbal ulcer-removing oral and oral cavity spray - Google Patents

Abstract

The invention relates to a natural herbal stomatocace-removing oral cavity spray, which comprises the active ingredients of witch hazel leachate, folium artemisiae argyi extract, poria cocos extract, isatis root extract, honeysuckle extract, ginseng stem cell extract, compound lysozyme, natural citric acid and the like, and is prepared by extracting and compounding through a special process. The invention aims to provide the natural herbal oral spray which is extracted from pure natural herbs and is not added with any chemical component, and particularly, high-tech natural sterilization and disinfection components such as ginseng stem cell extract, compound lysozyme and the like are added, so that the damaged oral mucosa can be effectively moistened and repaired, the effects of relieving and healing the oral ulcer are obvious, and the effect of freshening breath is achieved by clearing oral bacteria.

Description

Natural herbal ulcer-removing oral and oral cavity spray

The invention relates to a natural herbal mouth and mouth spray for removing ulcer, which is prepared from hamamelis virginiana leachate, folium artemisiae argyi extract, poria cocos extract, radix isatidis extract, honeysuckle extract, water lily stem cell extract, ginseng stem cell extract, chitosan, compound lysozyme, natural citric acid and the like through a special process. The invention aims to provide the natural herbal oral spray which is extracted from pure natural herbs and is not added with any chemical component, and particularly, high-tech natural sterilization and disinfection components such as ginseng stem cell extract, compound lysozyme and the like are added, so that the damaged oral mucosa can be effectively moistened and repaired, the effects of relieving and healing the oral ulcer are obvious, and the effect of freshening breath is achieved while oral bacteria are removed.

Background art oral health status is a mirror reflecting quality of life health, and oral health has become one of the standards for human health. Canker sores are the most common diseases in oral mucosal diseases, with a 5-25% incidence, and the causes may be local trauma, mental stress, food, drugs, hormonal level changes and vitamin or trace element deficiencies, and bacteria in the oral cavity play an important role in their development. Clinically, the treatment method mainly adopts symptomatic treatment and local application, has certain curative effect on treating the dental ulcer, but has the defects of inconvenient use, easy saliva washout of the medicine, slow medicine effect and the like, so that the treatment effect is influenced. Many other oral diseases, such as halitosis and pharyngolaryngitis, are also caused by oral bacteria. Modern medicine believes that oral diseases cause septicemia, diabetes, heart disease, etc. Therefore, killing pathogenic bacteria in the oral cavity is the key to preventing and treating oral diseases. Traditionally, antibiotics and bacteriostats are usually adopted to kill pathogenic bacteria in the oral cavity, and a spray is usually adopted for administration, but most of the existing sprays contain alcohol, so that the applicable groups of patients with oral diseases are limited, and some patients are allergic to alcohol; alcohol has side effects on the development of the nervous system of a pregnant fetus and an infant; and meanwhile, inconvenience is brought to the patient needing to drive the vehicle. Meanwhile, the spray containing the antibiotics and the bacteriostatic agent cannot be used for a long time, on one hand, bacteria can generate drug resistance, so that the sterilization effect of the antibiotics and the bacteriostatic agent is gradually reduced, and the curative effect is influenced; on the other hand, antibiotics and bacteriostats can destroy the ecological balance of intestinal flora and cause side effects such as gastrointestinal discomfort, so that an oral spray product which can be used for preventing oral diseases for a long time or cleaning the oral cavity daily and refreshing breath is lacked in the market. Aiming at the problems, the invention adopts the witch hazel leaching solution as the solvent, all antibacterial components are from natural herbaceous biological extracts, and the witch hazel washing liquid has the advantages of water solubility, easy volatilization, no washing, and three-in-one functions of washing, degerming and nursing. The cleaning and sterilizing liquid can furthest reduce the stimulation of the components to the skin of the organism and the damage to the physiological environment, has quick response, eliminates ulcer, relieves pain, promotes tissue regeneration and heals sore, and simultaneously adds the moisturizing component to play a role in nutrition and nursing oral mucosa. And has the characteristics of heat clearing and detoxifying, good stability, no environmental pollution, high safety performance and the like.

The key point of the invention is that proper components are selected, a plurality of natural herbal essences are used, the synergistic effect of the ginseng stem cell extract and the compound lysozyme is matched, so that the effect of each effective component is strongest, and finally the natural herbal ulcer-removing oral cavity and stomatal cavity spraying agent is prepared by compatibility.

The formula selected by the invention is as follows (components and weight percentage): 2.0-5.0% of ginseng stem cell extract; 2.0-5.0 of folium artemisiae argyi extract; poria extract 7.0-8.0 wt%; 2.0-5.0 parts of water lily stem cell extract; 5.0-7.0 parts of isatis root extract; 2.0-3.0 parts of honeysuckle extract; 1.0-3.0 of compound lysozyme; the natural citric acid adjusted the pH to 6.8 and the witch hazel permeate was added to 100.

Hamamelis mollis extract can be used as antioxidant; can activate cell aromatase and cathepsin to improve local estrogen level of cortex, enhance skin cell metabolism, has antiaging effect, and can maintain skin elasticity and remove wrinkle; has antiinflammatory, antiallergic, soothing and astringent effects; and simultaneously has good water holding capacity.

The folium Artemisiae Argyi extract has broad-spectrum antibacterial property, and can be used as antiseptic and antibacterial agent for cosmetics and oral hygiene products; the inhibition of nuclear factor receptor activation by the artemisia leaf extract indicates that the artemisia leaf extract can be used as a cosmetic anti-inflammatory agent; the extract can be used as antioxidant, antiwrinkle agent, antiallergic agent, pilatory, and humectant. The volatile oil has mild irritation to skin, and can cause fever and flush.

The radix Isatidis extract has effects of clearing away heat and toxic materials, cooling blood, etc., and the water extract has inhibitory effect on Bacillus subtilis, Staphylococcus aureus, Auricularia, Escherichia coli, Salmonella typhi, Bacillus paratyphi, dysentery (Shigella, Freund's) bacillus, and enteronitis bacillus.

The honeysuckle extract is known as a good medicine for clearing heat and removing toxicity from old times, has sweet and cold nature and aromatic qi, clears heat without hurting the stomach, can eliminate pathogenic factors by penetrating the aromatic qi, can disperse wind and heat, can also clear and remove blood toxin, is used for various heat diseases, such as fever, eruption, macula, heat toxin sore and carbuncle, sore throat and other symptoms, and has obvious effect.

The Poria extract has proliferation promoting effect on integrin which can reflect fibroblast proliferation and intercellular and fibrin adhesion, and can reduce diameter and volume of collagen wrapped by fibroblast, thereby having contraction effect, and can be used for skin tightening and fine line cosmetics; has antibacterial property, and has good inhibitory effect on various bacteria and fungi; it also has anti-inflammatory and moisture keeping effects.

The ginseng stem cell extract can inhibit the decomposition of collagen, promote the synthesis of collagen, repair skin cells damaged by ultraviolet rays and regenerate the damaged cells; help to form new keratin cells, make aged stratum corneum shed, activate new skin keratinocyte; proliferating to form fibroblast for maintaining skin elasticity, and making skin elastic; inhibiting the formation of active oxygen, eliminating the active oxygen and delaying the natural aging of skin cells; it has effects in dilating skin capillary, supplementing nutrition, regulating water and oil balance, keeping moisture, resisting wrinkle, inhibiting melanin formation, and whitening and smoothing skin.

The compound lysozyme is a part of an in vivo immune system and can effectively kill gram-positive bacteria. The complex lysozyme binds to the bacterial surface, reducing the negative charge and assisting phagocytosis of the bacteria. The complex lysozyme attacks the peptidoglycan, a component of the bacterial cell wall, hydrolyzing the glycosidic bond linking the fourth carbon atom of N-acetylmuramic acid and N-acetylglucosamine. Complex lysozyme binds to peptidoglycan molecules through the "groove" between its two domains; the substrate then forms a transition state conformation in the enzyme. The complex lysozyme binds to the dextranase according to the Phillips mechanism. The complex lysozyme then twisted the fourth sugar on the dextran hexaose into a half-chair conformation. In this distorted state (higher energy), the glycosidic bond is easily broken. Thereby achieving the sterilization effect.

The natural citric acid is extracted from fruits such as lemon, orange, pineapple and the like, belongs to one of fruit acids, and mainly has the effect of accelerating cutin renewal. It is often used in lotion, cream, shampoo, whitening product, anti-aging product, and acne product. The pH regulator used as skin refreshing liquid instead of chemical strong acid can play a good role in cutin renewal, and is helpful for stripping melanin in skin, shrinking pores, dissolving blackheads and the like.

The preparation method of the product of the invention comprises the following steps:

(1) preparing an oil phase component: respectively preparing folium Artemisiae Argyi extract, Poria extract, radix Isatidis extract, chitosan, and flos Lonicerae extract at a certain proportion, and mixing;

(2) preparing an aqueous phase component: adding the water lily stem cell extract and the ginseng stem cell extract into the witch hazel soaking solution in proportion, dissolving and stirring;

(3) heating the water phase component to 40 ℃, slowly adding the oil phase component, and emulsifying uniformly;

(4) cooling the components to 25 ℃, slowly adding the composite lysozyme, and uniformly stirring;

(5) using natural citric acid as an acid-base regulator, regulating the pH value of the solution to 6.0, and enabling the witch hazel to be soaked in the solution to be 100;

(6) randomly performing spot inspection, subpackaging into spray bottles after the inspection is qualified, labeling and sealing.

The invention has the following advantages:

(1) the ginseng stem cells, the compound lysozyme and the natural plant essence have synergistic effect, so that the effect of each effective component is strongest;

(2) the antibacterial and disinfection effect is obvious, and the bactericidal and bacteriostatic agent has the functions of killing and inhibiting bacteria, fungi and viruses;

(3) effectively eliminating bad breath and preventing infection;

(4) the oral cavity mask is safe, non-toxic, non-irritant, non-corrosive, non-destructive to oral mucosa and non-polluting to the environment;

(5) low use concentration, good stability, simple process and low cost.

The present invention will be described in further detail with reference to the following examples:

the configuration was carried out according to the data (in% by weight) listed in the following table and the procedure described therein:

the formula I is as follows:

2.0-5.0% of ginseng stem cell extract; 2.0-5.0 of folium artemisiae argyi extract; poria extract 7.0-8.0 wt%; 2.0-5.0 parts of water lily stem cell extract; 5.0-7.0 parts of isatis root extract; 2.0-3.0 parts of honeysuckle extract; 1.0-3.0 of compound lysozyme; the natural citric acid adjusted the pH to 6.8 and the witch hazel permeate was added to 100.

And a second formula:

3.0-5.0% of ginseng stem cell extract; 4.0-5.0 of folium artemisiae argyi extract; 7.5-8.0 of tuckahoe extract; 3.0-5.0 parts of water lily stem cell extract; 6.0-7.0 parts of isatis root extract; 2.5-3.0 parts of honeysuckle extract; 2.0-3.0 of compound lysozyme; the natural citric acid adjusted the pH to 6.8 and the witch hazel permeate was added to 100.

And the formula III:

2.0-4.0% of ginseng stem cell extract; 2.0-3.0 of folium artemisiae argyi extract; 7.5-8.0 of tuckahoe extract; 2.0-4.0 parts of water lily stem cell extract; 5.0-6.0 parts of isatis root extract; 2.0-2.8 of honeysuckle extract; 1.0-2.0 of compound lysozyme; the natural citric acid adjusted the pH to 6.8 and the witch hazel permeate was added to 100.

The applicant states that the present invention is illustrated by the above examples of the process of the present invention, but the present invention is not limited to the above process steps, i.e. it is not meant that the present invention must rely on the above process steps to be carried out. It will be apparent to those skilled in the art that any modification of the present invention, equivalent substitutions of selected materials and additions of auxiliary components, selection of specific modes and the like, which are within the scope and disclosure of the present invention, are contemplated by the present invention.

Claims (2)

1. A natural herbal ulcer-removing oral cavity and oral cavity cleaning spray is characterized by comprising the following components in percentage by weight: 2.0-5.0% of ginseng stem cell extract; 2.0-5.0 of folium artemisiae argyi extract; poria extract 7.0-8.0 wt%; 2.0-5.0 parts of water lily stem cell extract; 5.0-7.0 parts of isatis root extract; 2.0-3.0 parts of honeysuckle extract; 1.0-3.0 of compound lysozyme; the natural citric acid adjusted the pH to 6.8 and the witch hazel permeate was added to 100.

2. A method of preparing the natural herbal ulcer healing oral spray of claim 1, comprising the steps of:

(1) preparing an oil phase component: respectively preparing folium Artemisiae Argyi extract, Poria extract, radix Isatidis extract, chitosan, and flos Lonicerae extract at a certain proportion, and mixing;

(2) preparing an aqueous phase component: adding the water lily stem cell extract and the ginseng stem cell extract into the witch hazel soaking solution in proportion, dissolving and stirring;

(3) heating the water phase component to 40 ℃, slowly adding the oil phase component, and emulsifying uniformly;

(4) cooling the components to 25 ℃, slowly adding the composite lysozyme, and uniformly stirring;

(5) using natural citric acid as an acid-base regulator, regulating the pH value of the solution to 6.0, and enabling the witch hazel to be soaked in the solution to be 100;

(6) randomly performing spot inspection, subpackaging into spray bottles after the inspection is qualified, labeling and sealing.