CN101019948A - Acne treating compound Chinese medicine prepn - Google Patents
Acne treating compound Chinese medicine prepn Download PDFInfo
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- CN101019948A CN101019948A CNA2007100540989A CN200710054098A CN101019948A CN 101019948 A CN101019948 A CN 101019948A CN A2007100540989 A CNA2007100540989 A CN A2007100540989A CN 200710054098 A CN200710054098 A CN 200710054098A CN 101019948 A CN101019948 A CN 101019948A
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Abstract
The acne treating compound Chinese medicine preparation is prepared with ginseng, pearl powder, honeysuckle, dahurian angelica root, almond and other eight kinds of Chinese medicinal materials. The preparation process includes washing the medicine materials, crushing, decocting, filtering, centrifuging to obtain supernatant, concentrating, adding pearl powder, menthol, far infrared nanometer ceramic powder, etc, high temperature sterilizing, adding glycerin and ethanol. It has functions of resisting bacteria, relieving itch, reducing oil secretion, etc. and thus obvious acne treating effect and no side effect.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, relate to a kind of compound Chinese medicinal preparation for the treatment of acne.
Background technology
Facial acne is the modal pilosebaceous chronic inflammatory disease dermatosis of adolescence, claims again " acne ", and opinions vary to mechanism that acne form, still imperfectly understand so far, but with the human endocrine imbalance and outside infect relevant.The traditional Chinese medical science thinks, acne are that endogenous fire is flourishing, due to the stasis skin; Doctor trained in Western medicine thinks that then the adolescence acne send out because of androgen, and sebaceous gland is grown vigorous, and secretion increasing causes the sebum stasis of blood to be amassed in interior and form sebum thromboembolism-acne.The general NIP of acne, but when acne bacillus (Corynebactorium acne) growth is arranged in the hair follicle, just can produce molten esterase, make the sebum that accumulates in the acne decomposite free fatty, the hair follicle stimulating epidermis produces inflammatory reaction, makes face or chest the inflammatory pimple of many redness occur.Common ordinary acne (Acne Vulgaris) have blackhead, pus born of the same parents acne, skin sore and grain of rice sample cyst; just send out the stage in acne; if medical treatment or mishandling; regular meeting causes aleopation and forms scorching shape and invades profit; stay cicatrix or pigmentation so that harden gradually, canceration easily takes place in indivedual serious skins that also make.The method of treatment acne is a lot of both at home and abroad at present, as western medical treatment, medicine commonly used has erythromycin, chloromycetin etc., but these medicines easily cause toxic and side effects and anaphylaxis, treatment by Chinese herbs, common drug has pseudo-classic Margarita skin sore sheet, antiphlogistic forsythiae ball etc., but is being difficult to arrive satisfaction aspect cure rate, the therapeutic effect, in addition, though the cream of external frost can control inflammation, but hair follicle, glandular tube are stopped up more, cause vicious cycle, so curative effect is not good enough.
Summary of the invention
The purpose of this invention is to provide a kind of compound Chinese medicinal preparation for preparing the treatment acne simple, that therapeutic effect is good.
The present invention realizes above-mentioned purpose by the following technical solutions: a kind of compound Chinese medicinal preparation for the treatment of acne, mainly make by the raw material of following parts by weight:
Radix Ginseng 3～15 Margarita powder 0.1～5 Flos Lonicerae 5～20 Radixs Angelicae Dahuricae 3～15
Semen Armeniacae Amarum 4.5～25 Fructus Cnidiis 3～15 Herba Inulae 4.5～15 Radix Et Rhizoma Rhei 3～30
Radix Scutellariae 3～20 Radix Salviae Miltiorrhizaes 9～50 Fructus Bruceaes 0.5～25 Radix Sophorae Flavescentis 4.5～20
Flos Chrysanthemi Indici 9～15.
The compound Chinese medicinal preparation of treatment acne is preferably mainly made by the raw material of following parts by weight:
Radix Ginseng 5～10 Margarita powder 0.2～2 Flos Lonicerae 5～15 Radixs Angelicae Dahuricae 3～10
Semen Armeniacae Amarum 5～20 Fructus Cnidiis 3～10 Herba Inulae 5～10 Radix Et Rhizoma Rhei 5～20
Radix Scutellariae 5～15 Radix Salviae Miltiorrhizaes 10～30 Fructus Bruceaes 5～25 Radix Sophorae Flavescentiss 5～15
Flos Chrysanthemi Indici 10～15.
The compound Chinese medicinal preparation of treatment acne also comprises the raw material of following parts by weight: new azone 0.25～2 Flos Rosae Rugosae essence 0.5～2 Semen phaseoli radiati polypeptide 1～3 far infrared nano-ceramic powder 0.01～2 Mentholum 0.02～5.
The preparation method of the compound Chinese medicinal preparation of treatment acne may further comprise the steps:
(1), get Radix Ginseng, Flos Lonicerae, the Radix Angelicae Dahuricae, Semen Armeniacae Amarum, Fructus Cnidii, Herba Inulae, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Salviae Miltiorrhizae, Fructus Bruceae, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici and clean, pulverize, add the water boil of 6～8 times of weight, decocted 1～3 hour, get filtrate;
(2), the filtering residue decocting that adds 4～6 times of weight again boils 40min～1 hour, gets filtrate;
(3), merge twice filtrate, centrifugal behind the fine straining, leave standstill 30min～1 hour, extract supernatant, being concentrated into relative density is 1.10～1.25 (80 ℃);
(4), add Margarita powder, Mentholum, far infrared nano-ceramic powder, Semen phaseoli radiati polypeptide, new azone, allotment adds Flos Rosae Rugosae essence, adding distil water is made the medicinal liquid that relative density is 1.05～1.15 (80 ℃), flash-sterilization;
(5), add the ethanol account for the glycerol of medicinal liquid weight 40～60% and to account for medicinal liquid weight 40～60% and promptly make compound Chinese medicinal preparation.
Above-mentioned compound Chinese medicinal preparation according to the state of an illness or patient's acceptance difference, can be various clinical suitable dosage forms such as liniment, gel, membrane, liniment, lotion.
Compound preparation of the present invention has anti-bacterial, anti-itching, reduces fat secretion various skin acnes, suppresses effects such as follicular keratosis, and treatment is imitated significantly, and the cure rate height has no side effect, and drug dose is little, short treating period, economy.Radix Ginseng in the raw material of compound preparation is suitable for QI invigorating, adds excitometabolic, immunologic function, health invigorating; Margarita powder has multiple efficacies such as heat-clearing and toxic substances removing, skin maintenance, convergence granulation promoting; The Flos Lonicerae sweet in the mouth, cold in nature, have the effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens, be usually used in treating various carbuncle sore tumefacting virus etc. clinically; The Radix Angelicae Dahuricae has the hot pruritus of dispeling the wind, detumescence and apocenosis effect; Semen Armeniacae Amarum property of medicine hardship, tepor, loosening bowel to relieve constipation; The hot warm cold expelling of Fructus Cnidii, dispelling the damp pathogen with bitter and warm drugs, warm in nature supporing yang, solely go into kidney channel; Herba Inulae hardship, suffering, salty, temperature is returned lung, large intestine channel, treats pyogenic infections from tumour or sore outward; That Radix Et Rhizoma Rhei rushes down is scorchingly hot, removing mass stagnates, clots absorbing blood, the traditional Chinese medical science is used rhubarb treatment lung abscess, nasal abscess, carbuncle always, modern pharmacology studies have shown that, Radix Et Rhizoma Rhei has antibacterial action to most gram-positive bacteriums, and its antibacterial activity composition aloe-emodin, emodin and chrysophanic acid are to breathing, nucleic acid and proteinic synthetic the have obvious suppression effect of mushroom in culture medium; Radix Scutellariae nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication, but the heat of lung heat clearing stomach confirm that through pharmacology test Radix Scutellariae has wider antimicrobial spectrum, and staphylococcus aureus, bacillus pyocyaneus, streptococcus etc. are all had inhibitory action, the skin pathogenicity fungus is also had suppress to render a service; Radix Salviae Miltiorrhizae has blood circulation promoting and blood stasis dispelling, the effect of regulating QI to relieve pain; The Fructus Bruceae bitter cold is apt to control toxic-heat and blood stasis, and the external phagedenoma is removed wart; Radix Sophorae Flavescentis has clearing away heat-fire, the effect of detoxifcation dampness; The Flos Chrysanthemi Indici heat-clearing and toxic substances removing, detumescence all has inhibitory action to staphylococcus aureus, streptococcus, bacillus pyocyaneus, influenza virus etc.Above-mentioned raw materials is through organic assembling and dialectical compatibility, has heat clearing away, detoxifies, invigorates blood circulation, the itching relieving effect, thereby reach the purpose of curing acne.The new azone of auxiliary material is efficient skin penetration enhancer, and extremely strong transdermal effect is just arranged under low concentration, can help the skin absorbs medicinal liquid, and is non-stimulated to skin, do not have irritated reaction, nontoxic; Semen phaseoli radiati polypeptide can remove impression, makes skin whitening bright and clean, recovers elasticity; It is about 300 nanometers that far infrared nano-ceramic powder is selected fineness for use, transmitting power is 90% far infrared nano-ceramic powder, far infrared nano-ceramic powder can be launched 4～14 microns of the human body beneficial long far infrareies, improves histiocytic microcirculation and metabolism, promotes skin health; In addition, be added with glycerol, Mentholum in the middle of the preparation, glycerol is not volatile, mix arbitrarily with water, ethanol, skin is had the effect of preserving moisture, moistening and prolonging local drug effect, and Oleum menthae has the effect of refreshing and detoxicating, skin protection, and they help the performance of the physiological function of skin; Existing therapeutical effect has the effect of protection skin again, than simple application ethanol, has reduced the drying of skin, nervous sense, and zest is little, and the patient is easy to accept, and has a extensive future.
The specific embodiment
Embodiment, the compound Chinese medicinal preparation of treatment acne mainly selects for use the raw material of parts by weight in the following table to make respectively:
| Embodiment | 1 | ?2 | ?3 | ?4 | ?5 | ?6 | ?7 | ?8 | ?9 |
| Radix Ginseng | 3 | ?10 | ?15 | ?8 | ?12 | ?14 | ?6 | ?9 | ?11 |
| Margarita powder | 2 | ?0.2 | ?0.3 | ?5 | ?0.1 | ?3 | ?4 | ?0.9 | ?1 |
| Flos Lonicerae | 15 | ?12 | ?5 | ?18 | ?20 | ?10 | ?16 | ?12 | ?8 |
| The Radix Angelicae Dahuricae | 8 | ?3 | ?12 | ?9 | ?13 | ?15 | ?10 | ?6 | ?5 |
| Semen Armeniacae Amarum | 4.5 | ?12 | ?18 | ?8 | ?10 | ?5 | ?20 | ?22 | ?25 |
| Fructus Cnidii | 8 | ?3 | ?10 | ?6 | ?15 | ?12 | ?8 | ?4 | ?11 |
| Herba Inulae | 5 | ?10 | ?4.5 | ?9 | ?12 | ?8 | ?13 | ?6 | ?15 |
| Radix Et Rhizoma Rhei | 10 | ?20 | ?5 | ?12 | ?15 | ?3 | ?18 | ?8 | ?16 |
| Radix Scutellariae | 20 | ?10 | ?15 | ?3 | ?12 | ?5 | ?18 | ?8 | ?9 |
| Radix Salviae Miltiorrhizae | 15 | ?9 | ?30 | ?20 | ?10 | ?40 | ?50 | ?15 | ?25 |
| Fructus Bruceae | 0.5 | ?15 | ?10 | ?25 | ?2 | ?5 | ?20 | ?18 | ?8 |
| Radix Sophorae Flavescentis | 4.5 | ?10 | ?20 | ?15 | ?8 | ?5 | ?18 | ?12 | ?13 |
| Flos Chrysanthemi Indici | 15 | ?9 | ?10 | ?12 | ?15 | ?11 | ?10 | ?14 | ?12 |
| Mentholum | ?0.02 | ?3 | ?5 | ?0.1 | ?1 | ?4 | ?0.5 | ||
| Semen phaseoli radiati polypeptide | ?3 | ?1.5 | ?2 | ?2.5 | ?1 | ?3 | ?2 | ||
| New azone | ?1.5 | ?2 | ?0.5 | ?0.25 | ?1.8 | ?0.4 | ?0.7 | ||
| Ceramics | ?0.01 | ?2 | ?0.1 | ?0.5 | ?1 | ?1.5 | ?0.8 | ||
| Essence | ?0.7 | ?1 | ?1.5 | ?2 | ?0.8 | ?0.5 | ?1.2 |
The preparation of the compound Chinese medicinal preparation of treatment acne: get Radix Ginseng, Flos Lonicerae, the Radix Angelicae Dahuricae, Semen Armeniacae Amarum, Fructus Cnidii, Herba Inulae, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Salviae Miltiorrhizae, Fructus Bruceae, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici cleans, pulverize, the water boil that adds 6 times of weight, decocted 1 hour, get filtrate, the decocting that filtering residue adds 6 times of weight again boiled 40min hour, get filtrate, merge filtrate twice, centrifugal behind the fine straining, leave standstill 30min, extract supernatant, being concentrated into relative density is 1.20 (80 ℃), add Margarita powder again, Mentholum, far infrared nano-ceramic powder, Semen phaseoli radiati polypeptide, new azone, allotment adds essence, and adding distil water is made the medicinal liquid that relative density is 1.10 (80 ℃), flash-sterilization, add the glycerol that accounts for medicinal liquid weight 20% again, account for the ethanol of medicinal liquid weight 30%, make Traditional Chinese medicine liniment.
The clinical weight grade scale of acne:
The main skin lesion of I level (slightly) is acne, sends out in face.
The main skin lesion of II level (moderate) is acne, and a certain amount of pimple is arranged and shallowly mainly occur in face at the property pustule, occurs in cervical region, chest and back on a small quantity.
The main skin lesion of III level (severe) at property inflammatory pimple and pustule, betides face, cervical region, chest and back for deeply.
The present invention tests patient's totally 35 examples, wherein male 14 examples, women 21 examples; At 15～36 years old age, the course of disease is the shortest 1 month, and is the longest 4 years, and the skin lesion degree reaches 8 examples of III level, 17 examples of II level, 10 examples of I level.
Inclusion criteria: have typical clinical manifestation, meet the diagnostic criteria of above-mentioned acne vulgaris, do not do any Drug therapy in January, do not have the other diseases of merging.
Rejecting standard: to this product allergy sufferers; Prolonged application corticosteroid hormone person.
Medication and observational technique: dip in cotton swab and to get the compound recipe liniment for preparing, evenly be applied to the affected part, area is slightly larger than skin lesion, early, middle and late each once, but serious symptom every day four times increase once one month course of treatment just before going to bed.
The method of scoring: with clinical manifestation inflammation pimple, pus kitchen by there not being-0 fen, light-1 minute, in-2 minutes, heavy-3 minutes, adding up after the scoring both be clinical score, treatment back therapeutic index=(score one treatment back score before the treatment)/preceding score of treatment * 100%.
Efficacy determination adopts following standard:
The recovery from illness symptom disappears therapeutic index 〉=95% substantially;
The produce effects symptom is clearly better, therapeutic index 60～95%;
Effectively symptom takes a turn for the better, therapeutic index 20～60%;
Invalid therapeutic index＜20%
Clinical effectiveness sees the following form:
| The sick kind | The example number | Recovery from illness | Produce effects | Effectively | Invalid |
| Slightly | 10 | ?9 | ?1 | ||
| Moderate | 17 | ?10 | ?6 | ?1 | |
| Severe | 8 | ?2 | ?3 | ?1 | 2 |
As can be known from the above table, medicine total effective rate of the present invention is 94.3%, and cure rate is 60%, and treatment is imitated significantly, and the cure rate height has no side effect, and drug dose is little, short treating period, economy.
Claims (4)
1, a kind of compound Chinese medicinal preparation for the treatment of acne is characterized in that, is mainly made by the raw material of following parts by weight:
Radix Ginseng 3～15 Margarita powder 0.1～5 Flos Lonicerae 5～20 Radixs Angelicae Dahuricae 3～15
Semen Armeniacae Amarum 4.5～25 Fructus Cnidiis 3～15 Herba Inulae 4.5～15 Radix Et Rhizoma Rhei 3～30
Radix Scutellariae 3～20 Radix Salviae Miltiorrhizaes 9～50 Fructus Bruceaes 0.5～25 Radix Sophorae Flavescentis 4.5～20
Flos Chrysanthemi Indici 9～15.
2, the compound Chinese medicinal preparation of treatment acne as claimed in claim 1 is characterized in that, is mainly made by the raw material of following parts by weight:
Radix Ginseng 5～10 Margarita powder 0.2～2 Flos Lonicerae 5～15 Radixs Angelicae Dahuricae 3～10
Semen Armeniacae Amarum 5～20 Fructus Cnidiis 3～10 Herba Inulae 5～10 Radix Et Rhizoma Rhei 5～20
Radix Scutellariae 5～15 Radix Salviae Miltiorrhizaes 10～30 Fructus Bruceaes 5～25 Radix Sophorae Flavescentiss 5～15
Flos Chrysanthemi Indici 10～15.
3, treat the compound Chinese medicinal preparation of acne as claimed in claim 1 or 2, it is characterized in that, also comprise the raw material of following parts by weight:
New azone 0.25～2 Flos Rosae Rugosae essence 0.5～2 Semen phaseoli radiati polypeptide 1～3
Far infrared nano-ceramic powder 0.01～2 Mentholum 0.02～5.
4, the preparation method of the compound Chinese medicinal preparation of treatment acne is characterized in that, may further comprise the steps:
(1), get Radix Ginseng, Flos Lonicerae, the Radix Angelicae Dahuricae, Semen Armeniacae Amarum, Fructus Cnidii, Herba Inulae, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Salviae Miltiorrhizae, Fructus Bruceae, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici and clean, pulverize, add the water boil of 6～8 times of weight, decocted 1～3 hour, get filtrate;
(2), the filtering residue decocting that adds 4～6 times of weight again boils 40min～1 hour, gets filtrate;
(3), merge twice filtrate, centrifugal behind the fine straining, leave standstill 30min～1 hour, extract supernatant, being concentrated into relative density is 1.10～1.25 (80 ℃);
(4), add Margarita powder, Mentholum, far infrared nano-ceramic powder, Semen phaseoli radiati polypeptide, new azone, allotment adds Flos Rosae Rugosae essence, adding distil water is made the medicinal liquid that relative density is 1.05～1.15 (80 ℃), flash-sterilization;
(5), add the ethanol account for the glycerol of medicinal liquid weight 40～60% and to account for medicinal liquid weight 40～60% and promptly make compound Chinese medicinal preparation.
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| CN200710054098A CN100574778C (en) | 2007-03-23 | 2007-03-23 | The compound Chinese medicinal preparation of treatment acne |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101890117A (en) * | 2010-07-19 | 2010-11-24 | 伍平 | Traditional Chinese medicinal composition for treating acnes |
| CN103463202A (en) * | 2013-09-18 | 2013-12-25 | 吴秋业 | Oral traditional Chinese medicine preparation for treating acne and production process of oral traditional Chinese medicine preparation for treating acne |
| CN103989890A (en) * | 2014-05-18 | 2014-08-20 | 洛阳市安普生物科技有限公司 | Anti-fungus cream externally applied to skin |
| CN104771461A (en) * | 2015-03-16 | 2015-07-15 | 曾玉莹 | Traditional Chinese medicine spraying agent for treating acne and preparation method thereof |
| CN105012688A (en) * | 2015-06-30 | 2015-11-04 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine ointment used for treating keratosis pilaris, and preparation method thereof |
| CN105168360A (en) * | 2015-08-28 | 2015-12-23 | 吉林大学 | Compound plant extract liniment for treating acne and preparation method of compound plant extract liniment |
| CN105232589A (en) * | 2015-08-12 | 2016-01-13 | 万太保 | Compound acne treatment mixture and preparation method thereof |
| CN105362480A (en) * | 2014-08-12 | 2016-03-02 | 柯宏 | External application traditional Chinese medicine composition for acne prevention and treatment |
| CN106110064A (en) * | 2016-07-21 | 2016-11-16 | 魏晓兵 | A kind of anti acne of traditional Chinese medicine for external application |
| CN106880681A (en) * | 2017-03-18 | 2017-06-23 | 泰兴市丽姿生物制品有限公司 | A kind of removing acne and freckle beauty treatment Essence |
| CN109394861A (en) * | 2018-12-06 | 2019-03-01 | 广州市诺兰精细化工有限公司 | A kind of Chinese medicine face cream and preparation method improving skin acne inflammation |
| CN113384625A (en) * | 2021-07-20 | 2021-09-14 | 江清侠 | A Chinese medicinal composition for treating acne, and its preparation method |
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2007
- 2007-03-23 CN CN200710054098A patent/CN100574778C/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101890117A (en) * | 2010-07-19 | 2010-11-24 | 伍平 | Traditional Chinese medicinal composition for treating acnes |
| CN103463202A (en) * | 2013-09-18 | 2013-12-25 | 吴秋业 | Oral traditional Chinese medicine preparation for treating acne and production process of oral traditional Chinese medicine preparation for treating acne |
| CN103989890A (en) * | 2014-05-18 | 2014-08-20 | 洛阳市安普生物科技有限公司 | Anti-fungus cream externally applied to skin |
| CN105362480A (en) * | 2014-08-12 | 2016-03-02 | 柯宏 | External application traditional Chinese medicine composition for acne prevention and treatment |
| CN104771461A (en) * | 2015-03-16 | 2015-07-15 | 曾玉莹 | Traditional Chinese medicine spraying agent for treating acne and preparation method thereof |
| CN105012688A (en) * | 2015-06-30 | 2015-11-04 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine ointment used for treating keratosis pilaris, and preparation method thereof |
| CN105232589A (en) * | 2015-08-12 | 2016-01-13 | 万太保 | Compound acne treatment mixture and preparation method thereof |
| CN105168360A (en) * | 2015-08-28 | 2015-12-23 | 吉林大学 | Compound plant extract liniment for treating acne and preparation method of compound plant extract liniment |
| CN106110064A (en) * | 2016-07-21 | 2016-11-16 | 魏晓兵 | A kind of anti acne of traditional Chinese medicine for external application |
| CN106880681A (en) * | 2017-03-18 | 2017-06-23 | 泰兴市丽姿生物制品有限公司 | A kind of removing acne and freckle beauty treatment Essence |
| CN109394861A (en) * | 2018-12-06 | 2019-03-01 | 广州市诺兰精细化工有限公司 | A kind of Chinese medicine face cream and preparation method improving skin acne inflammation |
| CN113384625A (en) * | 2021-07-20 | 2021-09-14 | 江清侠 | A Chinese medicinal composition for treating acne, and its preparation method |
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| Publication number | Publication date |
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| CN100574778C (en) | 2009-12-30 |
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