CN108403909A - A kind of external application bacteriostatic agent, preparation method and its application - Google Patents
A kind of external application bacteriostatic agent, preparation method and its application Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Abstract
The invention discloses a kind of external application bacteriostatic agents, include following components by weight：2~10 parts of cortex phellodendri extract, 0.6~2 part of Folium Artemisiae Argyi extractive liquid, 0.6~2.5 part of Golden Larch Bark extracting solution, 0.2~1.5 part of Radix Sophorae Flavescentis extractive liquid, 0.1~1.2 part of Flos Carthami extract, 5~25 parts of extract solution from aloe, 1~4 part of campanulaceae extracting solution, 1~10 part of Chinese nutgall, 1~5 part of carbomer, 0.05~0.4 part of borneol, 2~10 parts of silver ion antimicrobial agent, 1~5 part of xanthans, 1.5~5 parts of glycerine, 40~150 parts of deionized water, 0.1~0.8 part of Phenoxyethanol.The invention also discloses the preparation method of the external application bacteriostatic agent and its applications on preparing vagina antibiosis antibacterial medicines.External application bacteriostatic agent of the present invention has antibacterial anti-inflammatory, contraception and improves vaginal dryness, bleeding.
Description
Technical field
The invention belongs to biological medicine sciemtifec and technical spheres, and in particular to the system of a kind of external application bacteriostatic agent and the external application bacteriostatic agent
Preparation Method and its application on preparing vagina antibacterial bacteriostatic drug.
Background technology
Gynaecological disease is that the gynecological clinics such as the common disease of women, such as vaginitis, cervicitis, pelvic infecton adnexitis are common
Disease, generally caused by cause pathogeny imcrobe infection.Such state of an illness is longer, and Relapse rate breaking-out, the state of an illness is more obstinate, seriously affects women
Physical and mental health and live and work.Due to various reasons, vagina can be by pathogenic bacterial infection or vagina part bacterium colony by women
Microenvironment stable state is broken, and leads to colporrhagia or various gynaecological diseases.In terms of Chinese medicine angle, the cause of disease disease of bacterial vaginosis BV
Machine is mostly because liver,spleen,kidney three is dirty and wind, cold, wet, hot heresy；The etiology and pathogenesis of trichomonas vaginitis is mainly because of damp-heat accumulation, worm
Caused by during erosion is cloudy；Monilial vaginitis etiology and pathogenesis mostly because it is wet it is turbid pent up, infect cult poison caused by；The cause of disease of senile vahinitis
Interpretation of the cause, onset and process of an illness main mechanism be the deficiency of liver-yin and kidney-yin, damp invasion of lower energizer, and mainly think in doctor trained in Western medicine by virus or germ infection caused by, vaginitis is given
Women's daily life causes to perplex, and may result in infertile, serious influence life and health.
Invention content
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide a kind of external application bacteriostatic agents, by outer
With the bacteriostatic agent, to treat vagina because of gynecological disease caused by various bacillary, fungoids and trichomonas infection.
The second object of the present invention is to provide a kind of preparation method of external application bacteriostatic agent, by the preparation method to prepare
External application bacteriostatic agent.
The third object of the present invention is to provide a kind of application of external application bacteriostatic agent on preparing vagina antibiosis antibacterial medicines.
An object of the present invention adopts the following technical scheme that realization：
A kind of external application bacteriostatic agent includes following components by weight：
2~10 parts of cortex phellodendri extract, 0.6~2 part of Folium Artemisiae Argyi extractive liquid, 0.6~2.5 part of Golden Larch Bark extracting solution, kuh-seng extraction
0.2~1.5 part of liquid, 0.1~1.2 part of Flos Carthami extract, 5~25 parts of extract solution from aloe, 1~4 part of campanulaceae extracting solution, Chinese gall carry
Take 1~10 part of liquid, 1~5 part of carbomer, 0.05~0.4 part of borneol, 2~10 parts of silver ion antimicrobial agent, 1~5 part of xanthans, sweet
1.5~5 parts of oil, 40~150 parts of deionized water, 0.1~0.8 part of Phenoxyethanol.
Further, by weight include following components：
3~5 parts of cortex phellodendri extract, 0.9~1.5 part of Folium Artemisiae Argyi extractive liquid, 0.8~2 part of Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid
0.5~1.2 part, 0.2~0.8 part of Flos Carthami extract, 8~18 parts of extract solution from aloe, 1.5~2.5 parts of campanulaceae extracting solution, Chinese gall
It is 3~8 parts of extracting solution, 2~4 parts of carbomer, 0.08~0.2 part of borneol, 5~8 parts of silver ion antimicrobial agent, 2~4 parts of xanthans, sweet
2.5~4 parts of oil, 50~100 parts of deionized water, 0.2~0.6 part of Phenoxyethanol.
Further, by weight include following components：
3 parts of cortex phellodendri extract, 1.2 parts of Folium Artemisiae Argyi extractive liquid, 1.2 parts of Golden Larch Bark extracting solution, 0.8 part of Radix Sophorae Flavescentis extractive liquid, safflower
0.4 part of extracting solution, 10.1 parts of extract solution from aloe, 1.8 parts of campanulaceae extracting solution, 5 parts of Chinese nutgall, 2.4 parts of carbomer, borneol
0.1 part, 7 parts of silver ion antimicrobial agent, 3 parts of xanthans, 3.6 parts of glycerine, 60 parts of deionized water, 0.4 part of Phenoxyethanol.
Further, the silver ion antimicrobial agent is at least one in silver nitrate, albumen silver, agysical and flamazine
Kind.
Further, the cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, safflower extraction
Liquid, extract solution from aloe, campanulaceae extracting solution and Chinese nutgall be the Cortex Phellodendris of corresponding parts by weight, folium artemisiae argyi, Golden Larch Bark, kuh-seng,
Safflower, aloe, campanulaceae and Chinese gall it is extracted after obtained extracting solution.
The second object of the present invention adopts the following technical scheme that realization：
A kind of preparation method of external application bacteriostatic agent, includes the following steps：
Prepare first material component：Deionized water, carbomer, xanthans and glycerine are placed in emulsification pot, stirred and evenly mixed
And 80~90 DEG C are warming up to, material is completely dissolved, and first material component is made；
Prepare second material component：First material component is cooled to 45~55 DEG C, and Cortex Phellodendri is added into first material component
Extracting solution, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, campanulaceae extracting solution and Chinese gall extraction
Liquid, constant temperature stir and evenly mix, and second material component is made；
Prepare external application bacteriostatic agent：Second material component is cooled to 20~40 DEG C, and aloe is added into second material component and carries
It takes liquid, silver ion antimicrobial agent, borneol and Phenoxyethanol, constant temperature to stir evenly, external application bacteriostatic agent is made.
Further, the cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, campanulaceae extracting solution and Chinese gall carry
Liquid is taken to obtain corresponding extracting solution by water extraction, the mass ratio of raw material and water is 1 in water extraction:2.5~10, water temperature raising
Degree is 80~90 DEG C, and water carries the time as 2.5~4h；
The Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract and extract solution from aloe are all made of 30~60% ethanol solution extraction, former
The mass ratio of material and ethanol solution is 1:5~12, Extracting temperature is 40~60 DEG C, and extraction time is 8~16h, obtained second
Alcohol extract is concentrated into and the weights such as raw material.
Further, the mass ratio of raw material and water is 1 in water extraction:5, water temperature raising degree be 85 DEG C, water carry the time be 3h,
Raw material shreds in advance；
Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract and extract solution from aloe are all made of 45% ethanol solution refluxing extraction, and raw material is pre-
It first shreds, the mass ratio of raw material and ethanol solution is 1:8, Extracting temperature is 50 DEG C, extraction time 10h.
Further, in preparing first material composition step, emulsify pot temperature be 85 DEG C, speed of agitator be 400~
600r/min stirs 15~30min.
Further, in preparing second material composition step, first material component is cooled to 50 DEG C, and speed of agitator is
180~250r/min, mixing time are 40~80min.
Further, in preparing external application bacteriostatic agent step, second material component is cooled to 25 DEG C, speed of agitator 120
~150r/min, mixing time are 60~180min.
The third object of the present invention adopts the following technical scheme that realization：
A kind of application of external application bacteriostatic agent on preparing vagina antibiosis antibacterial medicines.
Compared with prior art, the beneficial effects of the present invention are：
(1) a kind of external application bacteriostatic agent of the present invention has antibacterial and bacteriostasis to vagina, the external application bacteriostatic agent have efficiently,
The antibacterial effect of wide spectrum is a kind of nontoxic, tasteless and nonirritant, pollution-free, safe green bactericide product.The external application bacteriostatic agent
It is covered in vagina and cervical surface forms physics and chemical double barrier, protect female sex organs.This product pH value and vaginal pH
It is close, the normal colony balance of vagina and acid-base balance will not be destroyed, there is lubrication and nourishing effect, the dry of vagina can be improved
Puckery situation safeguards the favorable elasticity of vaginal wall.The present invention other than antibacterial and bacteriostasis, also has after testing and destroys spermatozoon activity
Effect to reach good contraceptive effect.Meanwhile external application bacteriostatic agent of the present invention also has conditioning vaginal wall, improves vagina
Dry and astringent, bleeding safeguards the favorable elasticity of vaginal wall, plays the role of lubrication and nourishes vagina.
(2) a kind of preparation method of external application bacteriostatic agent of the present invention has by the external application bacteriostatic agent that the preparation method is prepared
Standby above-mentioned antibacterial bacteriostatic, the dry and astringent situation for improving vagina, destruction spermatozoon activity and other effects.
(3) application of a kind of external application bacteriostatic agent of the present invention on preparing vagina antibiosis antibacterial medicines includes being somebody's turn to do by preparing
The vagina antibiosis antibacterial medicines of external application bacteriostatic agent active constituent, finally obtain it is a kind of with good antibacterial bacteriostatic, improve vagina
The gynecology externally used pharmaceutical of dry and astringent situation, destruction spermatozoon activity and other effects.
Specific implementation mode
In the following, in conjunction with specific implementation mode, the present invention is described further, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
1~5 illustrates a kind of concrete component of external application bacteriostatic agent of the present invention by the following examples.As shown in table 1, it is real
The concrete component list of example 1~5 and comparative example 1~5 is applied, wherein " " indicate to be free of the component.Cortex phellodendri extract, Chinese mugwort in table 1
Leaf extract, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, extract solution from aloe, campanulaceae extracting solution and Chinese gall extraction
Liquid be the Cortex Phellodendri that weight is corresponded in table, folium artemisiae argyi, Golden Larch Bark, kuh-seng, safflower, aloe, campanulaceae and Chinese gall it is extracted after
The extracting solution arrived.
The concrete component of 1 Examples 1 to 5 of table and the bacteriostatic agent corresponding to comparative example 1~5
In above-mentioned table 1, silver ion antimicrobial agent used in embodiment 1 is silver nitrate, and silver ion used in embodiment 2 is anti-
Microbial inoculum is agysical, and silver ion antimicrobial agent used in embodiment 3 is the mixture of 2Kg silver nitrates and 5Kg albumen silver composition, real
Apply the mixture that silver ion antimicrobial agent used in example 4 is 4Kg silver nitrates and 4Kg flamazines composition, it is used in embodiment 5
Silver ion antimicrobial agent be 2Kg albumen silver.Silver ion antimicrobial agent used in comparative example 1, comparative example 4 and comparative example 5 is 2Kg nitre
The mixture of sour silver and 5Kg albumen silver composition, silver ion antimicrobial agent used in comparative example 3 is 10Kg silver nitrates and 10Kg albumen
The mixture of silver composition.
Below by the preparation process of external application bacteriostatic agent in specific preparation method elaboration embodiment of the present invention 1-5 totally 5.
Embodiment 1
Prepare extracting solution：Cortex Phellodendri, folium artemisiae argyi, Golden Larch Bark, campanulaceae and Chinese gall in Example 1 respectively, first segment growth
It spends (or width) and is less than 1cm, then five kinds of groups are placed in five different tanks, be 1 according to the mass ratio of raw material and water:
2.5 addition pure water, are heated to 80 DEG C and maintain 4h, and cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extraction is made in strainer filtering
Liquid, campanulaceae extracting solution and Chinese nutgall.Kuh-seng, safflower in Example 1 and aloe, chopping to average grain diameter are 7mm,
It is 1 according to the mass ratio of raw material and ethanol solution:The ethanol solution of 5 additions 30% carries out refluxing extraction, Extracting temperature 40
DEG C, extraction time 8h, obtained ethanol extract is concentrated into and the weights such as raw material, obtained kuh-seng extraction by Rotary Evaporators
Liquid, Flos Carthami extract and extract solution from aloe.
Prepare first material component：Deionized water, carbomer, xanthans and glycerine in embodiment 1 is placed in emulsification pot
In, heating emulsification pot is warming up to 80 DEG C, meanwhile, 30min is stirred with the rotating speed of 400r/min, material is completely dissolved at this time, is made
First material component.
Prepare second material component：First material component is naturally cooling to 45 DEG C, system is added into first material component
Cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, the campanulaceae extracting solution and five got ready
Gall nut extracting solution, under 45 DEG C of constant temperatures, 180r/min stirs 80min, and second material component is made.
Prepare external application bacteriostatic agent：It waits for that second material component is naturally cooling to 20 DEG C, is added and prepares into second material component
Good extract solution from aloe and silver ion antimicrobial agent, borneol and Phenoxyethanol in embodiment 1,150r/min is stirred under the conditions of 20 DEG C
180min is mixed, external application bacteriostatic agent is made.
Embodiment 2
Prepare extracting solution：Cortex Phellodendri, folium artemisiae argyi, Golden Larch Bark, campanulaceae and Chinese gall in Example 2 respectively, first segment growth
It spends (or width) and is less than 1cm, then five kinds of groups are placed in five different tanks, be 1 according to the mass ratio of raw material and water:
4 addition pure water, are heated to 90 DEG C and maintain 3h, and cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extraction is made in strainer filtering
Liquid, campanulaceae extracting solution and Chinese nutgall.Kuh-seng, safflower in Example 2 and aloe, chopping to average grain diameter are 7mm,
It is 1 according to the mass ratio of raw material and ethanol solution:The ethanol solution of 12 additions 40% carries out refluxing extraction, Extracting temperature 40
DEG C, extraction time 16h, obtained ethanol extract is concentrated into and the weights such as raw material, obtained kuh-seng extraction by Rotary Evaporators
Liquid, Flos Carthami extract and extract solution from aloe.
Prepare first material component：Deionized water, carbomer, xanthans and glycerine in embodiment 2 is placed in emulsification pot
In, heating emulsification pot is warming up to 85 DEG C, meanwhile, 25min is stirred with the rotating speed of 400r/min, material is completely dissolved at this time, is made
First material component.
Prepare second material component：First material component is naturally cooling to 50 DEG C, system is added into first material component
Cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, the campanulaceae extracting solution and five got ready
Gall nut extracting solution, under 50 DEG C of constant temperatures, 200r/min stirs 60min, and second material component is made.
Prepare external application bacteriostatic agent：It waits for that second material component is naturally cooling to 25 DEG C, is added and prepares into second material component
Good extract solution from aloe and silver ion antimicrobial agent, borneol and Phenoxyethanol in embodiment 2,120r/min is stirred under the conditions of 25 DEG C
120min is mixed, external application bacteriostatic agent is made.
Embodiment 3
Prepare extracting solution：Cortex Phellodendri, folium artemisiae argyi, Golden Larch Bark, campanulaceae and Chinese gall in Example 3 respectively, first segment growth
It spends (or width) and is less than 1cm, then five kinds of groups are placed in five different tanks, be 1 according to the mass ratio of raw material and water:
5 addition pure water, are heated to 85 DEG C and maintain 3h, and cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extraction is made in strainer filtering
Liquid, campanulaceae extracting solution and Chinese nutgall.Kuh-seng, safflower in Example 3 and aloe, chopping to average grain diameter are 7mm,
It is 1 according to the mass ratio of raw material and ethanol solution:The ethanol solution of 8 additions 45% carries out refluxing extraction, Extracting temperature 50
DEG C, extraction time 10h, obtained ethanol extract is concentrated into and the weights such as raw material, obtained kuh-seng extraction by Rotary Evaporators
Liquid, Flos Carthami extract and extract solution from aloe.
Prepare first material component：Deionized water, carbomer, xanthans and glycerine in embodiment 3 is placed in emulsification pot
In, heating emulsification pot is warming up to 85 DEG C, meanwhile, 20min is stirred with the rotating speed of 500r/min, material is completely dissolved at this time, is made
First material component.
Prepare second material component：First material component is naturally cooling to 50 DEG C, system is added into first material component
Cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, the campanulaceae extracting solution and five got ready
Gall nut extracting solution, under 50 DEG C of constant temperatures, 200r/min stirs 60min, and second material component is made.
Prepare external application bacteriostatic agent：It waits for that second material component is naturally cooling to 25 DEG C, is added and prepares into second material component
Good extract solution from aloe and silver ion antimicrobial agent, borneol and Phenoxyethanol in embodiment 3,120r/min is stirred under the conditions of 25 DEG C
120min is mixed, external application bacteriostatic agent is made.
Embodiment 4
Prepare extracting solution：Cortex Phellodendri, folium artemisiae argyi, Golden Larch Bark, campanulaceae and Chinese gall in Example 4 respectively, first segment growth
It spends (or width) and is less than 1cm, then five kinds of groups are placed in five different tanks, be 1 according to the mass ratio of raw material and water:
10 addition pure water, are heated to 850 DEG C and maintain 3.5h, strainer filtering is made cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark and carries
Take liquid, campanulaceae extracting solution and Chinese nutgall.Kuh-seng, safflower in Example 4 and aloe, chopping to average grain diameter are
7mm is 1 according to the mass ratio of raw material and ethanol solution:The ethanol solution of 9 additions 60% carries out refluxing extraction, Extracting temperature
It it is 60 DEG C, extraction time 12h, obtained ethanol extract is concentrated into and the weights such as raw material, obtained kuh-seng by Rotary Evaporators
Extracting solution, Flos Carthami extract and extract solution from aloe.
Prepare first material component：Deionized water, carbomer, xanthans and glycerine in embodiment 4 is placed in emulsification pot
In, heating emulsification pot is warming up to 85 DEG C, meanwhile, 20min is stirred with the rotating speed of 600r/min, material is completely dissolved at this time, is made
First material component.
Prepare second material component：First material component is naturally cooling to 50 DEG C, system is added into first material component
Cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, the campanulaceae extracting solution and five got ready
Gall nut extracting solution, under 50 DEG C of constant temperatures, 200r/min stirs 60min, and second material component is made.
Prepare external application bacteriostatic agent：It waits for that second material component is naturally cooling to 30 DEG C, is added and prepares into second material component
Good extract solution from aloe and silver ion antimicrobial agent, borneol and Phenoxyethanol in embodiment 4,120r/min is stirred under the conditions of 30 DEG C
120min is mixed, external application bacteriostatic agent is made.
Embodiment 5
Prepare extracting solution：Cortex Phellodendri, folium artemisiae argyi, Golden Larch Bark, campanulaceae and Chinese gall in Example 5 respectively, first segment growth
It spends (or width) and is less than 1cm, then five kinds of groups are placed in five different tanks, be 1 according to the mass ratio of raw material and water:
8 addition pure water, are heated to 90 DEG C and maintain 2.5h, and cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extraction is made in strainer filtering
Liquid, campanulaceae extracting solution and Chinese nutgall.Kuh-seng, safflower in Example 5 and aloe, chopping to average grain diameter are 7mm,
It is 1 according to the mass ratio of raw material and ethanol solution:The ethanol solution of 12 additions 50% carries out refluxing extraction, Extracting temperature 60
DEG C, extraction time 14h, obtained ethanol extract is concentrated into and the weights such as raw material, obtained kuh-seng extraction by Rotary Evaporators
Liquid, Flos Carthami extract and extract solution from aloe.
Prepare first material component：Deionized water, carbomer, xanthans and glycerine in embodiment 5 is placed in emulsification pot
In, heating emulsification pot is warming up to 90 DEG C, meanwhile, 15min is stirred with the rotating speed of 400r/min, material is completely dissolved at this time, is made
First material component.
Prepare second material component：First material component is naturally cooling to 50 DEG C, system is added into first material component
Cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, the campanulaceae extracting solution and five got ready
Gall nut extracting solution, under 50 DEG C of constant temperatures, 200r/min stirs 60min, and second material component is made.
Prepare external application bacteriostatic agent：It waits for that second material component is naturally cooling to 40 DEG C, is added and prepares into second material component
Good extract solution from aloe and silver ion antimicrobial agent, borneol and Phenoxyethanol in embodiment 5,150r/min is stirred under the conditions of 40 DEG C
60min is mixed, external application bacteriostatic agent is made.
Comparative example 1
The preparation method of external application bacteriostatic agent in comparative example 1 is identical as the preparation method of embodiment 3, only difference is that：
External application bacteriostatic agent in comparative example 1 does not contain safflower extract.
Comparative example 2
The preparation method of external application bacteriostatic agent in comparative example 2 is identical as the preparation method of embodiment 3, only difference is that：
Difference in the dosage of folium artemisiae argyi and Golden Larch Bark, while the external application bacteriostatic agent in comparative example 2 does not contain silver ion antimicrobial agent.
Comparative example 3
The preparation method of external application bacteriostatic agent in comparative example 3 is identical as the preparation method of embodiment 3, only difference is that：
Cortex Phellodendri, folium artemisiae argyi, kuh-seng, aloe, campanulaceae root, Chinese gall and silver ion antimicrobial agent dosage on difference, while comparative example 3
Phenoxyethanol is not contained in external application bacteriostatic agent.
Comparative example 4
The distinctive points of the preparation method and the preparation method of embodiment 3 of external application bacteriostatic agent in comparative example 4 are：Comparative example
Cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, extract solution from aloe, campanulaceae in 4
Extracting solution and Chinese nutgall are made by water extraction.Wherein, the mass ratio of raw material and pure water is 1:5, water temperature raising
Degree is 85 DEG C, and water carries the time as 3h.
Comparative example 5
The distinctive points of the preparation method and the preparation method of embodiment 3 of external application bacteriostatic agent in comparative example 5 are：Comparative example
Cortex phellodendri extract, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, extract solution from aloe, campanulaceae in 5
Extracting solution and Chinese nutgall carry out refluxing extraction by 45% ethanol solution.Wherein, the matter of raw material and ethanol solution
The ratio between amount is 1:8, refluxing extraction temperature is 50 DEG C, reflux extracting time 10h.
Biocidal property is tested：
Root it is documented that, cause the pathogen of the gynecological diseases such as vaginitis, cervical erosion mainly to have：Candida albicans,
Staphylococcus aureus, trichomonad and gonococcus, according to GB15979-2002《Disposable Sanitary Accessory sanitary standard》It carries out
Quantitative disinfecting test, test result are shown in Table 2-5.
Bactericidal effect of the table 2 to Candida albicans
Bactericidal effect of the table 3 to staphylococcus aureus
Insecticidal effect of the table 4 to trichomonad
Bactericidal effect of the table 5 to gonococcus
By the test result of table 2-5 it is found that the external application bacteriostatic agent of 1-5 preparations of the embodiment of the present invention is to Candida albicans, gold
Staphylococcus aureus, trichomonad and gonococcus have good restraining and sterilizing bacteria effect, especially 3 corresponding bacteriostatic agent of embodiment,
It is antibacterial to kill an innings best results.Compared to embodiment 1-5, the restraining and sterilizing bacteria effect of comparative example 1-5 is poor, is unable to reach effective suppression
Bacterium is sterilized.
Contraception experiment：
Male rabbit 200 and the female rabbit 100 for taking fecundity correspond to 10 female rabbit by every 20 male rabbit and carry out
Random grouping, and label A groups (corresponding embodiment 1), B groups (corresponding embodiment 2), C groups (corresponding embodiment 3), D groups are (corresponding real
Apply example 4), E groups (corresponding embodiment 5), F groups (corresponding comparative example 1), H groups (corresponding comparative example 2), G groups (corresponding comparative example 3), H
Group (corresponding comparative example 4) and I groups (corresponding comparative example 5).Every preceding 24 hours intramuscular injection oestradiol benzoate of doe heat mating
0.1mg promotes the sexual maturity, and 10 kinds of external application bacteriostatic agents prepared by Example 1-5 and comparative example 1-5 carry out contraception experiment.By external application when experiment
Bacteriostatic agent is pushed by blunt nosed syringe in doe vagina, after 10min, by 1：2 mate doe with male rabbit, mate 30 days
After dissect doe, observe and count stillborn foetus, the results are shown in Table 6.
The contraception test result of table 6
As seen from the results in Table 6, the external application bacteriostatic agent that prepared by embodiment 1-5 is applied to doe, without stillborn foetus after mating 30 days,
Show that the external application bacteriostatic agent of embodiment 1-5 preparations can be effectively prevented from doe and become pregnant, there is good contraceptive effect.Compared to
Comparative example 1-5 has part doe to become pregnant successfully and (observes stillborn foetus), and contraceptive effect is poor.
Improve vaginal dryness, bleeding experiment：
Random 100 clinical manifestations of storage be vaginal dryness, easy bleeding female volunteers, give embodiment 1-5 and right
External application bacteriostatic agent treatment in ratio 1-5.Specific therapy is as follows：No one is each once by removing needle applicator daily morning and evening
External application bacteriostatic agent 2ml is injected, two courses for the treatment of (course for the treatment of is one month) is treated and counts vaginal dryness, bleeding afterwards.As a result
It is shown in Table 7.
Table 7 improve vaginal dryness, bleeding test result
By the result of table 7 as it can be seen that external application bacteriostatic agent of the present invention can improve well vaginal dryness, bleeding symptom, and
The less effective of external application bacteriostatic agent prepared by comparative example 1-5 to the symptom of improvement vaginal dryness, bleeding.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of external application bacteriostatic agent, which is characterized in that include following components by weight：
2~10 parts of cortex phellodendri extract, 0.6~2 part of Folium Artemisiae Argyi extractive liquid, 0.6~2.5 part of Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid 0.2
~1.5 parts, 0.1~1.2 part of Flos Carthami extract, 5~25 parts of extract solution from aloe, 1~4 part of campanulaceae extracting solution, Chinese nutgall 1
~10 parts, 1~5 part of carbomer, 0.05~0.4 part of borneol, 2~10 parts of silver ion antimicrobial agent, 1~5 part of xanthans, glycerine 1.5
~5 parts, 40~150 parts of deionized water, 0.1~0.8 part of Phenoxyethanol.
2. external application bacteriostatic agent as described in claim 1, which is characterized in that include following components by weight：
3~5 parts of cortex phellodendri extract, 0.9~1.5 part of Folium Artemisiae Argyi extractive liquid, 0.8~2 part of Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid 0.5
~1.2 parts, 0.2~0.8 part of Flos Carthami extract, 8~18 parts of extract solution from aloe, 1.5~2.5 parts of campanulaceae extracting solution, Chinese gall carry
Take 3~8 parts of liquid, 2~4 parts of carbomer, 0.08~0.2 part of borneol, 5~8 parts of silver ion antimicrobial agent, 2~4 parts of xanthans, glycerine
2.5~4 parts, 50~100 parts of deionized water, 0.2~0.6 part of Phenoxyethanol.
3. external application bacteriostatic agent as described in claim 1, which is characterized in that include following components by weight：
3 parts of cortex phellodendri extract, 1.2 parts of Folium Artemisiae Argyi extractive liquid, 1.2 parts of Golden Larch Bark extracting solution, 0.8 part of Radix Sophorae Flavescentis extractive liquid, safflower extraction
0.4 part of liquid, 10.1 parts of extract solution from aloe, 1.8 parts of campanulaceae extracting solution, 5 parts of Chinese nutgall, 2.4 parts of carbomer, borneol 0.1
Part, 7 parts of silver ion antimicrobial agent, 3 parts of xanthans, 3.6 parts of glycerine, 60 parts of deionized water, 0.4 part of Phenoxyethanol.
4. a kind of preparation method of external application bacteriostatic agent as described in any one of claims 1-3, which is characterized in that including following step
Suddenly：
Prepare first material component：Deionized water, carbomer, xanthans and glycerine are placed in emulsification pot, stirs and evenly mixs and rises
To 80~90 DEG C, material is completely dissolved temperature, and first material component is made；
Prepare second material component：First material component is cooled to 45~55 DEG C, and Cortex Phellodendri extraction is added into first material component
Liquid, Folium Artemisiae Argyi extractive liquid, Golden Larch Bark extracting solution, Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract, campanulaceae extracting solution and Chinese nutgall, it is permanent
Temperature stirs and evenly mixs, and second material component is made；
Prepare external application bacteriostatic agent：Second material component is cooled to 20~40 DEG C, into second material component be added extract solution from aloe,
Silver ion antimicrobial agent, borneol and Phenoxyethanol, constant temperature stir evenly, and external application bacteriostatic agent is made.
5. the preparation method of external application bacteriostatic agent as claimed in claim 4, which is characterized in that the cortex phellodendri extract, folium artemisiae argyi carry
Liquid, Golden Larch Bark extracting solution, campanulaceae extracting solution and Chinese nutgall is taken to obtain corresponding extracting solution, water extraction by water extraction
The mass ratio of middle raw material and water is 1:2.5~10, water temperature raising degree is 80~90 DEG C, and water carries the time as 2.5~4h；
The Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract and extract solution from aloe be all made of 30~60% ethanol solution extraction, raw material with
The mass ratio of ethanol solution is 1:5~12, Extracting temperature is 40~60 DEG C, and extraction time is 8~16h, and obtained ethyl alcohol carries
Liquid is taken to be concentrated into and the weights such as raw material.
6. the preparation method of external application bacteriostatic agent as claimed in claim 5, which is characterized in that the quality of raw material and water in water extraction
The ratio between be 1:5, water temperature raising degree is 85 DEG C, and water carries the time as 3h, and raw material shreds in advance；
Radix Sophorae Flavescentis extractive liquid, Flos Carthami extract and extract solution from aloe are all made of 45% ethanol solution refluxing extraction, and raw material is cut in advance
Broken, the mass ratio of raw material and ethanol solution is 1:8, Extracting temperature is 50 DEG C, extraction time 10h.
7. the preparation method of external application bacteriostatic agent as claimed in claim 4, which is characterized in that preparing first material composition step
In, the temperature for emulsifying pot is 85 DEG C, and speed of agitator is 400~600r/min, stirs 15~30min.
8. the preparation method of external application bacteriostatic agent as claimed in claim 4, which is characterized in that preparing second material composition step
In, first material component is cooled to 50 DEG C, and speed of agitator is 180~250r/min, and mixing time is 40~80min.
9. the preparation method of external application bacteriostatic agent as claimed in claim 4, which is characterized in that preparing external application bacteriostatic agent step
In, second material component is cooled to 25 DEG C, and speed of agitator is 120~150r/min, and mixing time is 60~180min.
10. a kind of application of external application bacteriostatic agent on preparing vagina antibiosis antibacterial medicines.
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