CN111657306A - Herbaceous plant silver ion composition and application thereof - Google Patents
Herbaceous plant silver ion composition and application thereof Download PDFInfo
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- CN111657306A CN111657306A CN202010568764.6A CN202010568764A CN111657306A CN 111657306 A CN111657306 A CN 111657306A CN 202010568764 A CN202010568764 A CN 202010568764A CN 111657306 A CN111657306 A CN 111657306A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention discloses a herbaceous plant silver ion composition and application thereof, which mainly comprises the following raw materials in percentage by weight: 0.15-0.5% of PEG-40 hydrogenated castor oil, 0.02-0.01% of essence, 0.5-1.0% of verbena extract, 0.5-1.0% of folium artemisiae argyi, 0.008-0.02% of silver, 2-4% of glycerol, 1-3% of butanediol, 0.27-0.63% of phenoxyethanol, 0.03-0.07% of caprylyl glycol, 0.04-0.1% of sodium citrate, 0.008-0.02% of silver sulfate, 0.16-0.4% of sodium dodecyl benzene sulfonate and 3.0-7.0% of pure water. The invention adopts a double sterilization mode, has the effects of eliminating bacterial pollution, removing heavy metal toxic substances and the like, and has stable and long-term antibacterial effect.
Description
Technical Field
The invention relates to the field of daily chemical articles, in particular to a herbaceous plant silver ion composition and application thereof.
Background
In daily life, silver is used as an antibacterial substance in daily chemical products, and the silver ion has a bactericidal effect so that the silver ion can kill organisms in vitro. Silver ions, as a new generation of natural antibacterial agents, have the following characteristics: broad-spectrum antibacterial sterilization and no drug resistance; the sterilization is strong, and a plurality of germs harmful to human bodies can be killed within a few minutes; the permeability is strong, the skin can be quickly infiltrated into the skin from pores for sterilization, and the skin has good sterilization effect on the infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria and fungi; and (3) healing promotion: improving the microbial environment of tissues around the wound, effectively activating and promoting the growth of tissue cells, accelerating the healing of the wound and reducing the generation of scars; the nano silver particles are produced by a patent technology, and a layer of protective film is arranged outside the nano silver particles and can be gradually released in a human body, so that the antibacterial effect is durable.
Herba Verbenae, also known as Longya Korea, herba Verbenae, and Verbenaceae, is cool in nature, slightly bitter in taste, and has effects of cooling blood, removing blood stasis, dredging channels, clearing heat, removing toxic substances, relieving itching, expelling parasites, and relieving flatulence. The verbena has good antibacterial and anti-inflammatory effects, and the water and alcohol extracts of the verbena have anti-inflammatory and analgesic effects.
Folium artemisiae argyi is bitter and pungent in taste, warm in nature and enters liver, spleen and kidney meridians, fragrant and warm in nature, and can rise and descend. Has the effects of warming channels, stopping bleeding, dispelling cold, relieving pain, reducing dampness and killing parasites. The folium artemisiae argyi fumigation can inhibit viruses and also can inactivate hepatitis B viruses, air parameters can reach normal after fumigation, and modern experimental studies prove that the folium artemisiae argyi has antibacterial and antiviral effects.
Although the existing silver ion-containing spray and gel contains silver ions as an antibacterial substance, the problems of relatively poor antibacterial effect, unstable antibacterial effect and short duration exist, so that a composition with good and stable antibacterial effect needs to be provided.
Disclosure of Invention
The invention aims to provide a herbaceous plant silver ion composition and application thereof, which have the effects of eliminating bacterial pollution and removing heavy metal toxic substances and the like through double sterilization and have stable and long-term antibacterial effect.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the herbal silver ion composition mainly comprises the following raw materials in percentage by weight: 0.15-0.5% of PEG-40 hydrogenated castor oil, 0.02-0.01% of essence, 0.5-1.0% of verbena extract, 0.5-1.0% of folium artemisiae argyi, 0.008-0.02% of silver, 2-4% of glycerol, 1-3% of butanediol, 0.27-0.63% of phenoxyethanol, 0.03-0.07% of caprylyl glycol, 0.04-0.1% of sodium citrate, 0.008-0.02% of silver sulfate, 0.16-0.4% of sodium dodecyl benzene sulfonate and 3.0-7.0% of pure water.
Preferably, the silver is elemental silver ions.
The herbal silver ion gel comprises the raw materials of the herbal silver ion composition as claimed in claim 1, and further comprises the following raw materials in percentage by weight: 0.1-0.2% of carbomer, 0.1-0.2% of triacetyl amine, 0.01-0.1% of PEG-75 shea butter glycerol and 0.0.15-0.5% of tremella polysaccharide.
Further, the triacetamide is diluted with water for use.
The preparation method of the herbal silver ion gel comprises the following steps:
a: the raw materials are divided into three phases A, B and C, wherein the phase A is pure water, carbomer and triacetyl amine; phase B is glycerol, butanediol, phenoxyethanol, caprylyl glycol, PEG-75 shea butter glyceride, Tremella polysaccharide, herba Verbenae extract, folium Artemisiae Argyi extract, PEG-40 hydrogenated castor oil, and essence; phase C is sodium citrate, sodium dodecyl benzene sulfonate, silver sulfate and pure water;
b: adding pure water into the phase A according to the amount, adding the pure water into an emulsifying pot, starting stirring, setting the speed of the emulsifying pot to be 35rmp/min, scattering carbomer powder into the center of a vortex according to the proportion, stirring for 1 hour, sampling to check whether the appearance is caked, adding TEA (TEA) if no caked, stirring and neutralizing to be in a completely transparent state, and keeping the time to be about 40-60 minutes;
c, adding the phase A after being treated, stirring and simultaneously opening vacuum defoamation (the vacuum pressure is-0.01-0.04), stirring for 30-50 minutes (after adding the phase A into the phase B, mixing and stirring, measuring the pH value, wherein the pH range is 6.5-7.5);
d: treating A, B phase, adding C phase (dispersing C phase with water for use), stirring for 30-40 min (after all raw materials are added, stirring thoroughly, measuring pH, and adjusting pH to 6-7); and simultaneously, after the phases of the step C and the step D are added, the vacuum defoaming is started in the whole process (after all the steps are finished, the viscosity needs to be measured, which is 1500-.
A herbal silver ion spray comprising the raw material of the herbal silver ion composition of claim 1, and further comprising the following raw materials in percentage by weight: 0.1-0.3% of PEG-75 shea butter glycerol, 0.1-0.3% of tremella polysaccharide, 0.1-0.3% of trehalose and 0.02-0.1% of sodium citrate.
The preparation method of the herbal silver ion spray comprises the following steps:
a: the raw materials are divided into three phases A, B and C, wherein the phase A is pure water, PEG-40 hydrogenated castor oil and essence; phase B is glycerol, butanediol, phenoxyethanol, caprylyl glycol, PEG-75 shea butter glyceride, Tremella polysaccharide, herba Verbenae extract, folium Artemisiae Argyi extract, sodium citrate, and trehalose; phase C is sodium citrate, sodium dodecyl benzene sulfonate, silver sulfate and pure water;
b: adding the phase A into pure water according to the amount, adding the pure water into an emulsifying pot, and starting stirring for about 40-60 minutes;
c: adding the phase B after the phase A is treated, and stirring for 30-50 minutes (measuring the PH value after the phase A is added with the phase B and stirring, and the PH range is 6.5-7.5);
d: treating A, B phase, adding C phase (dispersing C phase with water for use), and stirring for 30-40 min (after all materials are added, stirring thoroughly, measuring pH, and adjusting pH to 6-7).
Preferably, the essence treatment: mixing PEG-40 hydrogenated castor oil and essence at a ratio of 3-5:1, stirring, and dispersing for 10-15min until completely fused (properly slightly heated to 40 deg.C or below).
Compared with the prior art, the invention has the following beneficial effects:
1. the silver ions, the verbena and the folium artemisiae argyi are combined, so that the double sterilization is realized, the effects of eliminating bacterial pollution, removing heavy metal toxic substances and the like are realized, and the silver ion-containing traditional Chinese medicine is mild and nontoxic;
2. by adjusting the pH value, the protective effect on silver ions is enhanced under the condition of not influencing the water solubility of the silver ions in an alkaline environment, so that the silver ions are not easily oxidized under the conditions of high temperature and oxygen, and the silver ions have stable and long-term antibacterial effect.
Detailed Description
The present invention is further illustrated by the following examples, which are provided for the purpose of illustration only and are not intended to limit the scope of the present invention.
Example 1
The herbal silver ion gel comprises the following raw materials in percentage by weight: 0.15-0.5% of PEG-40 hydrogenated castor oil, 0.02-0.01% of essence, 0.5-1.0% of verbena extract, 0.5-1.0% of folium artemisiae argyi, 0.008-0.02% of silver, 2-4% of glycerol, 1-3% of butanediol, 0.27-0.63% of phenoxyethanol, 0.03-0.07% of caprylyl glycol, 0.04-0.1% of sodium citrate, 0.008-0.02% of silver sulfate, 0.16-0.4% of sodium dodecyl benzene sulfonate, 3.0-7.0% of pure water, 0.1-0.2% of carbomer, 0.1-0.2% of triethylamine, 0.01-0.1% of PEG-75 shea butter glycerol alcohol and 0.0.15-0.5% of tremella polysaccharide.
The silver adopted is simple substance silver.
Before the use of the triethylamine, the triethylamine is dispersed for later use by water so as to enlarge the contact area of the triethylamine, buffer and dilute the quality and avoid incomplete stirring caused by overhigh quality.
Essence treatment: mixing PEG-40 hydrogenated castor oil and essence at a ratio of 3-5:1, stirring, and dispersing for 10-15min until completely fused (properly slightly heated to 40 deg.C or below).
The preparation process comprises the following steps:
a: the raw materials are divided into three phases A, B and C, wherein the phase A is pure water, carbomer and triacetyl amine; phase B is glycerol, butanediol, phenoxyethanol, caprylyl glycol, PEG-75 shea butter glyceride, Tremella polysaccharide, herba Verbenae extract, folium Artemisiae Argyi extract, PEG-40 hydrogenated castor oil, and essence; phase C is sodium citrate, sodium dodecyl benzene sulfonate, silver sulfate and pure water;
b: scattering pure water and carbomer powder into an emulsifying pot according to a certain proportion, starting stirring at the speed of 35rmp/min, stirring for 1 hour, sampling to check whether the appearance is caked, adding TEA if no caked, stirring for neutralization to a completely transparent state, wherein the pH value is 6.5-7.5, and the whole stirring time is 40-60 minutes;
c: adding the phase A after being treated, stirring and simultaneously opening vacuum defoamation (the vacuum pressure is-0.01-0.04), stirring for 30-50 minutes (after adding the phase A into the phase B, mixing and stirring, measuring the pH value, wherein the pH range is 6.5-7.5);
before the A, B phase is added into the C phase, the silver ion raw material in the C phase is weighed and then mixed with pure water, stirred and dispersed, and the mass concentration of the silver ions is buffered and diluted so as to be better blended into the paste.
D: treating A, B phase, adding into C phase, and stirring for 30-40 min (after all materials are added, stirring thoroughly, measuring pH, and the pH range is 6-7).
And simultaneously, after the phases of the step B and the step C are added, the vacuum defoaming is started in the whole process (after all the steps are finished, the viscosity needs to be measured, which is 1500-.
Example 2
The herbal silver ion spray comprises the following raw materials in percentage by weight: 0.15-0.5% of PEG-40 hydrogenated castor oil, 0.02-0.01% of essence, 0.5-1.0% of verbena extract, 0.5-1.0% of folium artemisiae argyi, 0.008-0.02% of silver, 2-4% of glycerol, 1-3% of butanediol, 0.27-0.63% of phenoxyethanol, 0.03-0.07% of caprylyl glycol, 0.04-0.1% of sodium citrate, 0.008-0.02% of silver sulfate, 0.16-0.4% of sodium dodecyl benzene sulfonate, 3.0-7.0% of pure water, 0.1-0.3% of PEG-75 shea butter glycerol alcohol, 0.1-0.3% of tremella polysaccharide, 0.1-0.3% of trehalose and 0.02-0.1% of sodium citrate.
The silver adopted is simple substance silver.
The preparation process comprises the following steps:
a: the raw materials are divided into three phases A, B and C, wherein the phase A is pure water, PEG-40 hydrogenated castor oil and essence; phase B is glycerol, butanediol, phenoxyethanol, caprylyl glycol, PEG-75 shea butter glyceride, Tremella polysaccharide, herba Verbenae extract, folium Artemisiae Argyi extract, sodium citrate, and trehalose; phase C is sodium citrate, sodium dodecyl benzene sulfonate, silver sulfate and pure water;
b: adding PEG-40 hydrogenated castor oil and essence into an emulsifying pot at a ratio of 3-5:1, mixing, stirring, and dispersing for 10-15min (proper slight heating does not exceed 40 deg.C) until completely fused, adding pure water, stirring and dispersing for 40 min at normal temperature;
c: adding the phase B after the phase A is treated, and stirring for 30-50 minutes (measuring the PH value after the phase A is added with the phase B and stirring, and the PH range is 6.5-7.5);
before the A, B phase is added into the C phase, the silver ion raw material in the C phase is weighed and then mixed with pure water, stirred and dispersed, and the mass concentration of the silver ions is buffered and diluted so as to be better blended into the paste.
D: treating A, B phase, adding into C phase, and stirring for 30-40 min (after all materials are added, stirring thoroughly, measuring pH, and the pH range is 6-7).
Firstly, the following data table is obtained by detecting a herbaceous plant silver ion gel stock solution through a comparison experiment:
1. neutralizer identification test, test strain: escherichia coli and Candida albicans
Grouping: a, staining a bacteria sample plus 5ml of PBS;
b, staining a bacteria sample and 5ml of neutralizing agent;
c, staining the bacteria and adding 5ml of neutralizing agent;
d, taking a sample, 5MI neutralizer and an infectious bacterium pair photo;
e, staining the picture with 5ml of PBS;
f, PBS of the same batch;
g, neutralizing agent in the same batch;
h, the same batch of culture medium.
TABLE 1
Note: error rates between groups of lessons 3, 4 and 5 of 1.3 replicates were 7.31%, 6.79% and 7.21%, respectively.
And (4) experimental conclusion: the test result shows that the measured neutralizer is qualified.
TABLE 2
Note: error rates between groups of lessons 3, 4 and 5 of 1.3 replicates were 6.48%, 6.86% and 3.97%, respectively.
And (4) experimental conclusion: the test result shows that the measured neutralizer is qualified.
2. The sterilization performance is as follows:
(1) sample action concentration and time: the sample stock solution is applied for 2 min.
(2) Sample action concentration and time: the sample stock solution is applied for 5 min.
(3) Sample action concentration and time: the sample stock solution is applied for 10 min.
(4) Sample action concentration and time: the sample stock solution is applied for 20 min.
3. And (4) conclusion:
(1) and (3) identification test of a neutralizer: PBS solution containing 3% Tween-80, 0.5% sodium thiosulfate, 0.5% L-histidine, 0.5% peptone, 0.85% sodium chloride, 1.43% lecithin and 0.1% cysteine can effectively neutralize stock solution, and neutralizing agent and neutralization product have no adverse effect on Escherichia coli and Candida albicans;
(2) and (3) testing the sterilization performance: the sample stock solution has the action time of 2min, 5min, 10min and 20min respectively, has the sterilization rate of more than 90 percent on escherichia coli (ATCC 25922), staphylococcus aureus (ATCC 6538) and candida albicans (ATCC 10231), conforms to the standard value (the sterilization rate is more than or equal to 90 percent) specified in GB 15979 and 2002 appendix C3, and has the sterilization effect on the tested strain.
Secondly, the following data table is obtained by detecting the herbaceous plant silver ion spraying stock solution through a comparison experiment:
1. neutralizer identification test, test strain: escherichia coli and Candida albicans
Grouping: a, staining a bacteria sample plus 5ml of PBS;
b, staining a bacteria sample and 5ml of neutralizing agent;
c, staining the bacteria and adding 5ml of neutralizing agent;
d, taking a sample, 5MI neutralizer and an infectious bacterium pair photo;
e, staining the picture with 5ml of PBS; (ii) a
F, PBS of the same batch;
g, neutralizing agent in the same batch;
h, the same batch of culture medium.
TABLE 1
Note: error rates between groups of lessons 3, 4 and 5 of 1.3 replicates were 8.94%, 8.02% and 4.39%, respectively.
And (4) experimental conclusion: the test result shows that the measured neutralizer is qualified.
TABLE 2
Note: error rates between groups of lessons 3, 4 and 5 of the 1.3 replicates were 6.67%, 10.10% and 5.69%, respectively.
And (4) experimental conclusion: the test result shows that the measured neutralizer is qualified.
2. The sterilization performance is as follows:
(1) sample action concentration and time: the sample stock solution is applied for 2 min.
(3) Sample action concentration and time: the sample stock solution is applied for 5 min.
(3) Sample action concentration and time: the sample stock solution is applied for 10 min.
(4) Sample action concentration and time: the sample stock solution is applied for 20 min.
3. And (4) conclusion:
(1) and (3) identification test of a neutralizer: PBS solution containing 3% Tween-80, 0.5% sodium thiosulfate, 0.5% L-histidine, 0.5% peptone, 0.85% sodium chloride, 1.43% lecithin and 0.1% cysteine can effectively neutralize stock solution, and neutralizing agent and neutralization product have no adverse effect on Escherichia coli and Candida albicans;
(2) and (3) testing the sterilization performance: the sample stock solution has the action time of 2min, 5min, 10min and 20min respectively, has the sterilization rate of more than 90 percent on escherichia coli (ATCC 25922), staphylococcus aureus (ATCC 6538) and candida albicans (ATCC 10231), conforms to the standard value (the sterilization rate is more than or equal to 90 percent) specified in GB 15979 and 2002 appendix C3, and has the sterilization effect on the tested strain.
According to the embodiment of the invention, the verbena, the folium artemisiae argyi and the silver ions are combined, so that the dual sterilization is realized, the effects of eliminating bacterial pollution, removing heavy metal toxic substances and the like can be realized, and the effects of mildness and no toxicity are realized; the pH value is adjusted by using the neutralizing agent, and the protective effect on silver ions is enhanced under the condition of not influencing the water solubility of the silver ions in an alkaline environment, so that the silver ions are not easily oxidized under the conditions of high temperature and oxygen, and the silver ions have stable and long-term antibacterial effect.
The above examples only show two embodiments of the present invention, and the description thereof is specific and detailed, and therefore should not be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the spirit of the present invention, and these changes and modifications are all within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. The herbal silver ion composition is characterized by mainly comprising the following raw materials in percentage by weight: 0.15-0.5% of PEG-40 hydrogenated castor oil, 0.02-0.01% of essence, 0.5-1.0% of verbena extract, 0.5-1.0% of folium artemisiae argyi, 0.008-0.02% of silver, 2-4% of glycerol, 1-3% of butanediol, 0.27-0.63% of phenoxyethanol, 0.03-0.07% of caprylyl glycol, 0.04-0.1% of sodium citrate, 0.008-0.02% of silver sulfate, 0.16-0.4% of sodium dodecyl benzene sulfonate and 3.0-7.0% of pure water.
2. The herbal silver ion composition of claim 1, wherein the silver is elemental silver ion.
3. The herbal silver ion gel is characterized by comprising the raw materials of the herbal silver ion composition according to claim 1, and further comprising the following raw materials in percentage by weight: 0.1-0.2% of carbomer, 0.1-0.2% of triacetyl amine, 0.01-0.1% of PEG-75 shea butter glycerol and 0.0.15-0.5% of tremella polysaccharide.
4. The herbal silver ion gel according to claim 3, wherein the triacetamide is diluted with water.
5. The herbaceous plant silver ion gel according to claim 4, characterized in that the preparation method comprises the following steps:
a: the raw materials are divided into three phases A, B and C, wherein the phase A is pure water, carbomer and triacetyl amine; phase B is glycerol, butanediol, phenoxyethanol, caprylyl glycol, PEG-75 shea butter glyceride, Tremella polysaccharide, herba Verbenae extract, folium Artemisiae Argyi extract, PEG-40 hydrogenated castor oil, and essence; phase C is sodium citrate, sodium dodecyl benzene sulfonate, silver sulfate and pure water;
b: adding pure water into the phase A according to the amount, adding the pure water into an emulsifying pot, starting stirring, setting the speed of the emulsifying pot to be 35rmp/min, scattering carbomer powder into the center of a vortex according to the proportion, stirring for 1 hour, sampling to check whether the appearance is caked, adding TEA (TEA) if no caked, stirring and neutralizing to be in a completely transparent state, and keeping the time to be about 40-60 minutes;
c, adding the phase A after being treated, stirring and simultaneously opening vacuum defoamation (the vacuum pressure is-0.01-0.04), stirring for 30-50 minutes (after adding the phase A into the phase B, mixing and stirring, measuring the pH value, wherein the pH range is 6.5-7.5);
d: treating A, B phase, adding C phase (dispersing C phase with water for use), stirring for 30-40 min (after all raw materials are added, stirring thoroughly, measuring pH, and adjusting pH to 6-7); and simultaneously, after the phases of the step C and the step D are added, the vacuum defoaming is started in the whole process (after all the steps are finished, the viscosity needs to be measured, which is 1500-.
6. The herbal silver ion spray is characterized by comprising the raw materials of the herbal silver ion composition according to claim 1, and further comprising the following raw materials in percentage by weight: 0.1-0.3% of PEG-75 shea butter glycerol, 0.1-0.3% of tremella polysaccharide, 0.1-0.3% of trehalose and 0.02-0.1% of sodium citrate.
7. The herbal silver ion spray according to claim 6, characterized in that the preparation method comprises the following steps:
a: the raw materials are divided into three phases A, B and C, wherein the phase A is pure water, PEG-40 hydrogenated castor oil and essence; phase B is glycerol, butanediol, phenoxyethanol, caprylyl glycol, PEG-75 shea butter glyceride, Tremella polysaccharide, herba Verbenae extract, folium Artemisiae Argyi extract, sodium citrate, and trehalose; phase C is sodium citrate, sodium dodecyl benzene sulfonate, silver sulfate and pure water;
b: adding the phase A into pure water according to the amount, adding the pure water into an emulsifying pot, and starting stirring for about 40-60 minutes;
c: adding the phase B after the phase A is treated, and stirring for 30-50 minutes (measuring the PH value after the phase A is added with the phase B and stirring, and the PH range is 6.5-7.5);
d: treating A, B phase, adding C phase (dispersing C phase with water for use), and stirring for 30-40 min (after all materials are added, stirring thoroughly, measuring pH, and adjusting pH to 6-7).
8. The process according to claim 5 or claim 7, wherein the perfume treatment: mixing PEG-40 hydrogenated castor oil and essence at a ratio of 3-5:1, stirring, and dispersing for 10-15min until completely fused (properly slightly heated to 40 deg.C or below).
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