CN111184757A - Plant folium artemisiae argyi extract and silver ion compound bactericide and preparation method thereof - Google Patents
Plant folium artemisiae argyi extract and silver ion compound bactericide and preparation method thereof Download PDFInfo
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- CN111184757A CN111184757A CN202010203317.0A CN202010203317A CN111184757A CN 111184757 A CN111184757 A CN 111184757A CN 202010203317 A CN202010203317 A CN 202010203317A CN 111184757 A CN111184757 A CN 111184757A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N27/00—Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Abstract
The plant folium artemisiae argyi extract and silver ion compound bactericide is mainly prepared from nano silver ions, folium artemisiae argyi flavone, myricetin, selenium, wormwood alcohol, sabinene, menthene, vitamin E and the like, utilizes the synergistic effect of mineral nano silver, the plant folium artemisiae argyi extract and other substances, solves the defects of the traditional sterilization, exerts the adsorption performance of the nano silver ions, the exchange performance of organic negative oxygen ions and the micromolecule performance of active folium artemisiae argyi, and leads the product to add plant activity by combining the silver ions and the active micromolecules of the folium artemisiae argyi, organic mineral water and mineral water active trace elements, makes up the defects of the similar mineral water, improves the added value of the cost performance of the product, shows the scientificity of the product and the gold content of the core technology, has the effect of physical therapy and has wider practicability; the compound physical and chemical reaction ensures that the product micromolecules are more full and abundant in liquid state, and realizes perfect fusion of organic and inorganic; the product has more excellent and stable performance and antibacterial performance.
Description
The technical field is as follows:
the invention discloses a plant folium artemisiae argyi extract and silver ion compound bactericide, and further provides a preparation method of the bactericide, which is applied to daily washing and nursing, public environment cleaning, sterilization and disinfection, article disinfection, disease prevention and sanitary nursing, and belongs to the technical field of disinfection and sterilization sanitary products.
Background
The wormwood is a composite plant (namely artemisia argyi) and the artemisia argyi is a very important traditional Chinese medicine and is commonly called king of hundred grass. The "days of materia Medica" records: the folium artemisiae argyi has faint scent, leaves are pungent and warm in taste, can be used for removing diseases and diseases, dispelling cold and relieving pain, and is mild and dredging collaterals, and also has the effects of removing toxicity and removing dirt, and warming and activating qi and blood; the components and the pharmacology of the folium artemisiae argyi are as follows: the main components of the folium Artemisiae Argyi oil are folium Artemisiae Argyi alcohol and artemisinin, and the medicinal value and the special effects of physical therapy of resisting virus, resisting oxidation, resisting allergy, resisting blood coagulation, enhancing immunity, and delaying skin aging.
The invention content is as follows:
the invention aims to provide a plant folium artemisiae argyi extract and silver ion compound bactericide which contains various superimposed effects and actions, has a remarkable pharmacological action of antibacterial activity, overcomes the defects of single substance and the like in the sterilization process, provides an optimal solution, and increases the practicability and the physical therapy action of products.
The invention also provides a preparation method of the plant folium artemisiae argyi extract and silver ion compound bactericide, which is suitable for standardized and specialized production of products.
The plant folium artemisiae argyi extract and silver ion compound bactericide is characterized by being mainly prepared from the following raw materials in parts by weight:
15-27% nano silver ion: 23-24 parts of folium artemisiae argyi flavone: 0.02-0.03 parts of myricetin: 0.03-0.05 part, selenium: 0.02-0.04 parts of absinthin: 0.01-0.02 parts of sabinene: 0.02-0.05 parts of menthene: 0.01-0.02 parts of vitamin E: 0.1-0.2 parts of mineral water: 72-74 parts.
The preparation method of the plant folium artemisiae argyi extract and silver ion compound bactericide comprises the following steps:
weighing the raw materials in proportion; heating mineral water at 100 deg.c, adding nano silver ion, stirring to melt and materialize completely, adding other material in certain proportion, physical and chemical reaction for 10-15 min, pouring into container, and naturally standing for 30 min to obtain the stock solution of the present invention.
The plant folium artemisiae argyi extract and silver ion compound bactericide can be mixed with a pharmaceutically acceptable carrier or excipient to form a medicinal preparation, and the preparation comprises external preparations such as a spray, an aerosol, a cream, an ointment, a gel, a sterilized wet tissue, a sterilized cotton stick, sterilized gauze, a band-aid and the like.
[ DOSAGE ADMINISTRATION ] can be sprayed or applied topically.
[ APPLICATION RANGE ] the in vitro disinfection and killing of various bacteria and viruses.
The formula solution is as follows:
in the pharmacological aspect, the folium artemisiae argyi contains various active molecules, and can be used for clearing away heat and toxic materials, warming channels and expelling cold, dredging collaterals and relieving pain, regulating qi and blood, relaxing muscles and tendons and removing diseases, inhibiting bacteria and stopping bleeding, resisting anaphylaxis and the like. The folium Artemisiae Argyi flavone has antiviral, antifungal, and air purifying effects. The anti-oxidation effect of the argyi leaf alcohol can eliminate free radicals, and sabinene and menthene in the argyi leaf have good regulating effect on central nervous system and respiratory system; selenium has the special effects of whitening skin, removing acne and delaying skin aging. Vitamin E has good antioxidant activity.
The biological chemical components and pharmacological action of the folium artemisiae argyi: the folium artemisiae argyi is an indispensable traditional Chinese medicine variety and has obvious curative effect and application, the biochemical components comprise volatile oil, oleum artemisiae argyi, caryophyllene oxide and borneol, the folium artemisiae argyi flavone is a main biochemical component in the folium artemisiae argyi, the content is about 13.42 percent,
because the flavonoids compounds are widely existed in plants, the mugwort incense is volatilized after the flavonoids compounds are contacted with air, and the practicability of the product is improved.
Ag2+ is a boundary acid, forms hydride more readily than Ag +, Ag (OH)2Therefore, the solution containing Ag2+ is weakly acidic, but its hydroxide solubility is high (the solubility is equivalent to that of sodium carbonate), so that when the plant folium Artemisiae Argyi small molecular extract is added, Ag (OH) is not generated2Precipitate, and can react with organic reagent and inorganic reagent. The reaction with mineral water is very vigorous. The alkali metal which reacts with hydrogen at about 100 to 500 ℃ is the only alkali metal which can form a stable oxide without decomposition, and the electrolysis energy is 5. 3p2 microelectronic volts, chemically bonded to oxygen, nitrogen, sulfur, selenium, alcohols, sodium, etc., are the only ones that react with nitrogen to lithium oxide (Li 3N).
As is known, nano silver ion is a sterilization and disinfection preparation, belongs to the class of non-antibiotics, is one of trace elements which must be taken in by human bodies and can be used for treating diseases by being taken as a medicine, and has the following antibacterial mechanism effects:
(1) interfere the synthesis of cell walls, the constituent part of the bacterial cell walls is peptidoglycan which mainly inhibits the cross-linking of polysaccharide chains and peptides, thereby leading the integrity of the cell walls to be lost, losing the protection effect on osmotic pressure, damaging thalli and dying,
(2) the cell membrane can be damaged and is an important part of bacterial cell propagation, so that the damage of cells, such as cell damage, can cause the death of bacteria.
(3) Inhibiting protein synthesis, altering protein synthesis process, and killing bacteria
(4) Silver ion is one of ions with the strongest sterilizing capability and belongs to colorless ions, and the nano silver ion is an inorganic antibacterial agent, and negative oxygen ions in water are materialized in the dissolving process of the silver ion, and when oxygen is converted into thalli, the bacteria are killed.
(5) The bactericidal mechanism of silver ions, silver ions (Ag +) contact with bacteria, causing the destruction of bacterial proteins. Causing bacterial death, the contact principle is based on charge adsorption, since the cell membrane carries a negative charge and the silver ions (Ag +) carry a positive charge, as a result of which the silver ions penetrate the cell membrane into the bacterial core, killing the sulfhydryl groups of the proteins inside the bacteria.
The invention has the positive effects that:
by utilizing the synergistic effect of the mineral nano silver, the plant folium artemisiae argyi extract and other substances, the defects of traditional sterilization are overcome, the adsorption performance of nano silver ions, the negative oxygen ion exchange performance of organic mineral water and the micromolecule performance of active folium artemisiae argyi are exerted, the plant activity of the product is increased by combining the silver ions, the active micromolecule of the folium artemisiae argyi, the organic mineral water and the active trace elements of the mineral water, the defects of similar products are overcome, the added value of the cost performance of the product is improved, the scientificity of the product and the gold content of a core technology are shown, the physiotherapy effect is realized, and the practicability is wider; the compound physical and chemical reaction ensures that the product micromolecules are more full and abundant in liquid state, and realizes perfect fusion of organic and inorganic; the product has more excellent and stable performance and antibacterial performance.
Detailed Description
The present invention is further illustrated by the following examples, which do not limit the present invention in any way, and any modifications or changes that can be easily made by a person skilled in the art to the present invention will fall within the scope of the claims of the present invention without departing from the technical solution of the present invention.
Example 1
Weighing 23 g of nano silver ions with the concentration of 27% (mg/kg), 0.02 g of folium artemisiae argyi flavone, 0.03 g of myricetin, 0.02 g of selenium, 0.01g of wormwood alcohol, 0.02 g of sabinene, 0.01g of menthene, 0.1 g of vitamin E and 72 g of mineral water;
heating mineral water at 100 deg.c, adding nano silver ion, stirring to melt and materialize completely, adding other material in certain proportion, physical and chemical reaction for 10-15 min, pouring into container, and naturally standing for 30 min to obtain the stock solution of the present invention.
Example 2
Weighing 24 g of nano silver ions with the concentration of 15% (mg/kg), 0.03 g of folium artemisiae argyi flavone, 0.04 g of myricetin, 0.03 g of selenium, 0.02 g of wormwood alcohol, 0.03 g of sabinene, 0.02 g of menthene, 0.2 g of vitamin E and 74 g of mineral water;
heating mineral water at 100 deg.c, adding nano silver ion, stirring to melt and materialize completely, adding other material in certain proportion, physical and chemical reaction for 10-15 min, pouring into container, and naturally standing for 30 min to obtain the stock solution of the present invention.
Example 3
Weighing 23 g of nano silver ions with the concentration of 27% (mg/kg), 0.02 g of folium artemisiae argyi flavone, 0.03 g of myricetin, 0.02 g of selenium, 0.01g of wormwood alcohol, 0.02 g of sabinene, 0.01g of menthene, 0.1 g of vitamin E and 72 g of mineral water;
heating mineral water at 100 deg.c, adding nano silver ion, stirring to melt and materialize completely, adding other material in certain proportion for 10-15 min, pouring into container, and naturally standing for 30 min to obtain the stock solution.
Example 4
The stock solution prepared in the embodiment 1-3 and a pharmaceutically acceptable carrier or excipient are used for forming a pharmaceutical preparation, and the preparation comprises external preparations such as spray, aerosol, cream, ointment, gel, sterilized wet tissue, sterilized cotton stick, sterilized gauze and band-aid.
The positive factors and effects are shown by the following test examples:
first, PH value detection
Mineral water was added to 1.0g (to an accurate amount of 0.01g) of each of the preparations of examples 1 to 3, the mixture was melted and subjected to a physicochemical reaction for 15 minutes to a volume of 10mL, and the results of the measurement showed that example 1 had a pH of 8.03, example 2 had a pH of 8.35, and example 3 had a pH of 8.09.
The total free alkali in the sample is detected according to the specification of Q/2623.1-2003, and the experimental result shows that the alcoholic lysate of 3 examples can not lead the phenolphthalein indicator to develop pink, thereby proving that no free caustic alkali is detected in the alcoholic lysate, and proving that the sample has good safety and no irritation to the skin.
Secondly, according to the regulations of the Ministry of public health of the people's republic of China, 3 cases of implementation are carried out to test the bacteriostatic activity of escherichia coli (ATCC25922), staphylococcus aureus (ATCC 6538) and candida albicans (ATCC 10231). The invention tests the bacteriostatic activity (see table 1)
Table 1:
the experimental results show that the active argy wormwood leaf silver ions in the 3 groups of examples can achieve 99.98% of inhibition rate on escherichia coli (ATCC25922), 99.98% of inhibition rate on staphylococcus aureus (ATCC 6538), 99.98% of inhibition rate on candida albicans (ATCC10231), and strong antibacterial activity due to the synergy of the medicines.
Acne removal and whitening performance detection
Thirdly, through the experimental determination of tyrosinase in the embodiments 1 to 3: the inhibition rate of the embodiment 1 to the tyrosinase is 4.33 percent; the inhibition rate of the example 2 on the tyrosinase is 4.38%; example 3 showed 4.17% inhibition of tyrosinase.
The conclusion is that the high-activity argy wormwood leaf has good inhibition rate and is proved to have super-strong disinfection and sterilization effect.
Fourthly, the activity detection of the anti-influenza virus (FM1) of the invention
The influenza virus A mouse lung adapted strain (FM1) is adopted to carry out drug antiviral activity detection, MDCK cells are infected by the influenza virus, the cytopathic effect of the drug on the virus is observed, the drug antiviral effective rate is calculated, and the neuraminidase activity is measured. The experimental results are shown in table 2;
table 2:
the experimental results show that the inhibition rate of 3 groups of implementation cases on various germs can reach 99.98 percent, and the antiviral and physiotherapy effect is obvious.
And (4) conclusion:
according to the invention, the silver ion element of the active argy wormwood leaf is nontoxic and tasteless in physicochemical reaction, particularly, the liquid body is vaporific and volatilizes without smell in the using process, and the light fragrance of a proper amount of argy wormwood is added into the silver ion preparation, so that the added value and the practicability of the silver ion spray are improved, and the application scene is more perfect in the using and volatilizing process.
The total free flow alkali detection in the sample is carried out according to the regulation of Q/T2623.1-2003, and the experimental result shows that the ethanol lysate of 3 examples can not develop pink color by using the dare indicator, the ethanol lysate of the 3 examples has no free dorsal base detection, and the sample has good safety and no irritation to the skin.
Fifthly, the window inhibition activity detection of the invention
The antibacterial activity of Escherichia coli (ATCC25922), Staphylococcus aureus (ATCC 6538) and Candida albicans (ATCC10231) was tested in 3 cases according to the Disinfection technical Specification (2002 edition) of the Ministry of public health of the people's republic of China. See table 3 for the results of the test:
table 3:
detecting items
Bacterial colony total number, fungal colony total number, coliform group, staphylococcus aureus, pseudomonas aeruginosa, hemolytic streptococcus, neutralizer identification test and sterilization performance
1, microorganism index detection, wherein the detection results of the items detected by the sample, such as coliform bacteria, pseudomonas aeruginosa, staphylococcus aureus, hemolytic streptococcus, total bacterial colonies and total fungal colonies, meet the requirements of GB 15979-.
2. The neutralizer identification test shows that the 'active folium artemisiae argyi silver ion antibacterial spray' can be effectively neutralized by a PBS solution containing 3% of tween-80.0.5% of sodium thiosulfate, 0.5% of L-histidine, 0.5% of protein, 0.85% of sodium chloride, 1.43% of lecithin and 0.1% of cysteine, and the neutralizer and a neutralization product have no adverse effect on escherichia coli and candida albicans.
Detection conclusion
3. The bactericidal performance Test shows that the sample stock solution has the action time of 2min, 5min, 10min and 20min respectively, the bactericidal rate to Test Conclusion | bacillus coli (ATCC25922), staphylococcus aureus (ATCC 6538) and candida albicans (ATCC10231) is more than 99.98 percent, the standard value (the bactericidal rate is more than 90 percent) specified in GB 15979 and 2002 appendix C3 is met, and the bactericidal effect to the tested strain is realized.
4. The culture medium comprises nutrient agar and Sa's lipid
The method comprises the following steps:
1. the detection basis is GB 15979-2002 appendix B of hygienic Standard for Disposable sanitary products.
2. The detection conditions comprise that the ambient temperature is 23.2 ℃ and the relative humidity is 53 percent.
See table 4 for results;
table 4:
note that the negative controls all grew aseptically
Sixthly, conclusion:
the detection results of the items detected by the sample, such as coliform bacteria, pseudomonas aeruginosa, staphylococcus aureus, hemolytic streptococcus, total bacterial colonies and total fungal colonies, meet the requirements of GB 15979-.
The combined formula solves the problem of singleness of other products, and the compound physical and chemical reactions lead the small molecules of the products to be in liquid state and to be more full and rich, thereby realizing perfect integration of organic and inorganic. The product has more excellent and stable performance and antibacterial performance. The acid resistance, the alkali resistance and the chlorine resistance are better, the material can be mixed with solutions such as sodium chloride and calcium chloride, the safety and the environmental protection conform to the RoHS/REACH European Union environmental protection test, and the material is suitable for being widely applied in the range of PH value.
See table 5 for technical wood indices;
table 5:
Claims (3)
1. the plant folium artemisiae argyi extract and silver ion compound bactericide is characterized by being mainly prepared from the following raw materials in parts by weight:
15-27% nano silver ion: 23-24 parts of,
Folium artemisiae argyi flavone: 0.02 to 0.03 portion,
Myricetin: 0.03 to 0.05 portion of,
Selenium: 0.02 to 0.04 part by weight,
Absinthol: 0.01 to 0.02 part,
Sabinene: 0.02 to 0.05 portion,
Menthene: 0.01 to 0.02 part,
Vitamin E: 0.1 to 0.2 part,
Mineral water: 72-74 parts.
2. The preparation method of the plant artemisia leaf extract and silver ion compound bactericide as claimed in claim 1, comprising the following steps:
weighing the raw materials in proportion; heating mineral water at 100 deg.c, adding nano silver ion, stirring to melt and materialize completely, adding other material in certain proportion for 10-15 min, pouring into container, and naturally standing for 30 min for physical and chemical reaction.
3. The plant artemisia leaf extract and silver ion compound bactericide as claimed in claim 1, which can be mixed with a pharmaceutically acceptable carrier or excipient to form a pharmaceutical preparation, wherein the preparation comprises a spray, an aerosol, a cream, an ointment, a gel, a sterilized wet tissue, a sterilized cotton stick, a sterilized gauze and a wound plaster for external use.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111657306A (en) * | 2020-06-19 | 2020-09-15 | 广东一芙化妆品有限公司 | Herbaceous plant silver ion composition and application thereof |
| CN112274462A (en) * | 2020-09-17 | 2021-01-29 | 浙江森马服饰股份有限公司 | Composite bacteriostatic agent with bacteriostatic and epidermal moisturizing effects and preparation and application thereof |
| CN112471174A (en) * | 2020-12-01 | 2021-03-12 | 徐州医科大学 | Nano-silver/domiphen bromide composite antibacterial agent and preparation method and application thereof |
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| CN111657306A (en) * | 2020-06-19 | 2020-09-15 | 广东一芙化妆品有限公司 | Herbaceous plant silver ion composition and application thereof |
| CN112274462A (en) * | 2020-09-17 | 2021-01-29 | 浙江森马服饰股份有限公司 | Composite bacteriostatic agent with bacteriostatic and epidermal moisturizing effects and preparation and application thereof |
| CN112471174A (en) * | 2020-12-01 | 2021-03-12 | 徐州医科大学 | Nano-silver/domiphen bromide composite antibacterial agent and preparation method and application thereof |
| CN112471174B (en) * | 2020-12-01 | 2021-06-04 | 徐州医科大学 | Nano-silver/domiphen bromide composite antibacterial agent and preparation method and application thereof |
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Application publication date: 20200522 |