CN101502569A - Sanitary hydrojet for cleaning vagina and preparation method - Google Patents
Sanitary hydrojet for cleaning vagina and preparation method Download PDFInfo
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- CN101502569A CN101502569A CNA2009100107652A CN200910010765A CN101502569A CN 101502569 A CN101502569 A CN 101502569A CN A2009100107652 A CNA2009100107652 A CN A2009100107652A CN 200910010765 A CN200910010765 A CN 200910010765A CN 101502569 A CN101502569 A CN 101502569A
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- hydrojet
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Abstract
A vagina-cleaning sanitary spray liquid comprises vagina-cleaning spray liquid and a liquid spray bottle, and the vagina-cleaning spray liquid consists of the following pharmaceutical components by weight percentage: 0.146-0.15 wt percent of hexamethylene guanidine hydrochloride, 0.195-0.2 wt percent of glycerol, 0.097-0.1 wt percent of peony root extract, 0.029-0.03 wt percent of rosemary oil and 1.95-2.0 wt percent of diphenhydramine. The components are mixed and prepared into water solution, the vagina-cleaning spray liquid is filled in the liquid spray bottle, and a liquid spray head is sealed for preparing the vagina-cleaning sanitary spray liquid. The vagina-cleaning sanitary spray liquid can not only effectively kill bacteria and viruses of skin and mucous membrane parts of whole body, but also have better effect for killing adult male and female genital skin and mucous membrane infected bacteria, fungi and viruses, thereby having the effect of killing bacteria, fungi, gonorrhea coccus, human papilloma virus and HIV and being capable of effectively preventing female bacterial vaginosis, fungal vaginitis, male and female gonorrhea, genital warts, AIDS and so on.
Description
Technical field
The present invention relates to the medicine spray, particularly relate to a kind of pudendum that is used for and nurse, play the sanitary hydrojet for cleaning vagina and the preparation method of prevention and health care and sterilization, sterilization, antivirus action.
Background technology
Unavoidable contact antibacterial, fungus and virus in people's the routine work.When skin and secretion mucosa self-resistance are low, pathogenic microorganism can be taken advantage of a weak point, cause part or systemic infection disease, infringement people's body, and because the difference of the daily physiological hygiene protection of the special physiological position of women and male genitals and people, cause women's vulva and male external genital organs disease, sickness rate height and cure rate is low.JIEERYIN has become the leading clean cloudy medicament of control in recent years, this medicament has certain therapeutic effect to aerobic microbial vaginitis, because a large amount of antibiotic that use in ill back, people have been formed the dependency of medicament and the drug resistance of stubbornness, therefore pressing for development can nurse pudendum, plays the new product of prevention and health care and sterilization, sterilization, antivirus action.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of sanitary hydrojet for cleaning vagina and preparation method that can play prevention and health care and sterilization, sterilization, antivirus action to pudendum.
The technical scheme that adopts is:
A kind of sanitary hydrojet for cleaning vagina comprises clean cloudy hydrojet and hydrojet bottle.Described clean cloudy hydrojet is by following drug component and percentage by weight:
Polyhaxemethylenguanidine Hydrochloride 0.146-0.15wt%
Glycerol 0.195-0.2wt%
Radix Paeoniae Alba extract 0.097-0.1wt%
Rosemary ethereal oil 0.029-0.03wt%
Diphenhydramine 1.95-2.0wt%
The pure water surplus
Be hybridly prepared into clean cloudy hydrojet by above-mentioned component.In realizing production, can enlarge at double according to producing needs.
Pharmacology in the above-mentioned component:
Polyhaxemethylenguanidine Hydrochloride (Polyhexamethelenneguanidine Hydrochloride PHMG).PHMG is the wide spectrum disinfectant, characteristics are that sterilizing power is strong, effect fast, good stability, actual nontoxic level .0.3%PHMG effect 2min get final product 100% and kill escherichia coli, staphylococcus aureus, Candida albicans, Hemolytic streptococcus; 0.1%PHMG effect 5min can kill HIV (human immunodeficiency virus); 0.5%PHMG effect 1min can kill HIV (human immunodeficiency virus).The skin irritation test is 0 grade, and is non-stimulated.Acute toxicity test: 1%PHMG LD50 is greater than the nontoxic level in the true border of 5000mg/kgBW.The sterilization mechanism of PHMG: it belongs to polyguanidine family macromolecule polymer, in aqueous solution, can produce ionization, its hydrophilic group partly contains intensive electropositive, absorption is electronegative all kinds of bacterial virus usually, thereby antibacterial, virus breeding have been suppressed, add that the thin film of polymer formation has stopped up the ion channel of this part microorganism, make its rapid death by suffocation, reach best bactericidal effect.Studying data at home and abroad shows that PHMG is the desirable disinfectant of safe and effective kill bacteria, fungus, virus.
Glycerol is humidizer
Radix Paeoniae Alba extract Paronia pall Extract
The source: this product is the dry root from ranunculaceae plant Radix Paeoniae (paeoBia lactiflora Pall), extracts with new and high technology is refining.Its English Paeoniflorin by name;
Molecular formula: C2 3H28011; Molecular weight: 480.45.
Character: there is strong Radix Paeoniae abnormal smells from the patient at pale brown toner end.
Product specification: contain active ingredient paeoniflorin 10%-50%HPLC and detect.
Effect and purposes: paeoniflorin has nourishing blood for regulating menstruation, astringing YIN to stop sweating, suppressing the hyperactive liver analgesic function.Be used for diseases such as dysmenorrhea, amenorrhea, pain in chest and hypochondrium, stomachache, limb pain twin, headache are dizzy, haematemesis.
Rosemary ethereal oil, the essential oil that from natural flower of Herba Rosmarini Officinalis, extracts, its fragrance is suitable, clinical practice cephalocathartic relieving fatigue, diuresis helps gets rid of moisture retention symptom in the female menstrual period, and the menstrual cramps of releiving changes very few through blood flow, for the natural antibacterial agent that skin is itched, can eliminate skin turgor and edema.
Benzene ditch Lamine, but have another name called that quick, Diphenhydramine of that monarch of benzene.White crystalline powder, odorless, bitter in the mouth, very easily water-soluble.Clinical practice: Mucocutaneous allergy, as urticaria, vasodilation, allergic rhinitis, pruritus ani, pruritus vulvae, contact dermatitis and other skin pruritus.
Described clean cloudy hydrojet of the present invention is filled in the described hydrojet bottle of moulding system, and seals up jet head and make sanitary hydrojet for cleaning vagina.
The present invention is except that effective to whole skin mucosal sites kill bacteria virus, better to adult's male and female pudendum skin, mucosal infections antibacterial, fungus, viral killing effect, antibacterial, fungus, micrococcus gonococcus, human papillomavirus, HIV (human immunodeficiency virus) are had killing action, can effectively prevent bacterial vaginitis, colpitis mycotica, men and women's gonorrhea, condyloma acuminatum, acquired immune deficiency syndrome (AIDS) of women etc.
The preparation method of sanitary hydrojet for cleaning vagina comprises the steps:
Step 1
Prepare clean cloudy hydrojet, take by weighing Polyhaxemethylenguanidine Hydrochloride, glycerol, Radix Paeoniae Alba extract, rosemary ethereal oil and diphenhydramine and pure water is mixed into aqueous solution by clean cloudy hydrojet component;
Step 2
In moulding system hydrojet bottle, and encapsulation goes up jet head with the clean cloudy hydrojet fill of preparation, sanitary hydrojet for cleaning vagina of the present invention.
The present invention detects through disease prevention and control center, Liaoning Province, and it is as follows that it detects conclusion:
Detect conclusion:
1. microorganism detection
Test repeats 3 times, and test temperature is 20 ℃ ± 1 ℃.When sanitary hydrojet for cleaning vagina content is stock solution, contain 3.0g/L lecithin, volume fraction is the nertralizer of the 0.03mol/LPBS of 3% Tween 80, effectively in the neutralization solution and thalline remained on surface disinfectant to the effect of test organisms, and nertralizer and neutralized reaction product thereof have no adverse effects to test organisms and culture medium.
The microorganism of sanitary hydrojet for cleaning vagina (total number of bacterial colonies, coliform, fungus colony sum, pathogenic suppuration bacterium) detects the regulation that meets State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB 15979-2002.
2. staphylococcus aureus bacteriostatic test (suspension method)
According to State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002, test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Sanitary hydrojet for cleaning vagina (effective ingredient Chinese herbal medicine etc.) concentration is stock solution, and be 2mim action time, is 100% to the average bacteriostasis rate of staphylococcus aureus.Has strong bacteriostasis.
3. Candida albicans bacteriostatic test (suspension method)
According to State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002, test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Sanitary hydrojet for cleaning vagina (effective ingredient Chinese herbal medicine etc.) concentration is stock solution, and be 2min action time, is 100% to the oidiomycetic average bacteriostasis rate of white.Has strong bacteriostasis.
Sanitary hydrojet for cleaning vagina is tested skin irritation
Exempt from as animal subject its method during test in vain with big ear:
24h removes the hair of rabbit back both sides skin before the test, and the unhairing scope is 3 * 3cm
2, the left side is contrast (blank), the right is the trial zone, gets next day to be tried thing and be cut into 2.5 * 2.5cm
2Size contains the about 0.5ml of wet tissue liquid and directly sticks on trial zone skin, covers with two-layer gauze and the non-stimulated plastic foil of one deck then, and reuse nonirritant adhesive plaster is fixed, sealing 4h.Check that in 1h, the 24h, the 48h that remove after being tried thing the rabbit skin reacts, and the record result, the second portion sterile products inspection technology standard invading the exterior 2-11 that presses " disinfection technology standard " (2002) carries out skin irritation reaction scoring.
Result of the test shows:
The rabbit skin is no abnormal in test, and skin irritation reaction top average (stimulation index) is 0, and the result shows that being tried thing belongs to nonirritant to rabbit skin irritant test.
The specific embodiment
Raw material
Adopt the grand hydrojet bottle that rises the production of plastics package factory in Zhengzhou City, Henan.
The Polyhaxemethylenguanidine Hydrochloride that adopts the big gram of Qingdao gram biochemical technology company limited to produce.
The Radix Paeoniae extracting solution that adopts Shanghai Xiang Hui bio tech ltd to produce.
Adopt the rosemary ethereal oil of the rich trade Co., Ltd of Guangzhou Australia supply.
The diphenhydramine that adopts Liaoyuan enlightening health Pharmaceutical Co., Ltd to produce.
The spraying bottle can packing machine that adopts the rich plant equipment company limited of Shanghai Jim to produce.
Embodiment one
1, the clean cloudy hydrojet of preparation 10000g
Take by weighing:
Polyhaxemethylenguanidine Hydrochloride 15g
Glycerol 20g
Radix Paeoniae Alba extract 10g
Rosemary ethereal oil 3g
Diphenhydramine 200g
Pure water 9752g
Be mixed with hydrochloric polyhexamethylene guanidine 0.15wt%, glycerol 0.2wt%, Radix Paeoniae Alba extract 0.1wt%, rosemary ethereal oil 0.03wt%, the clean cloudy hydrojet of diphenhydramine 2.0wt%.
2, adopt the spraying bottle can packing machine, with clean cloudy hydrojet fill in moulding system hydrojet bottle.
3, through the hydrojet bottle capping of the clean cloudy hydrojet of fill, and hand over quality inspection, quality inspection comprises sense organ requirement, physical and chemical index, microbiological indicator, fungistatic effect and sanitary toxicology.
Sense organ requires to meet table 1 regulation
The requirement of table 1 sense organ
Project | Requirement |
Color and luster | Colourless |
Abnormal smells from the patient | Tasteless |
Character | Liquid |
Impurity | No meat is obeyed visible impurity and foreign body |
Physical and chemical index should meet table 2 regulation
Table 2 physical and chemical index
Project | Index |
Active substance content | 0.146—0.15% |
PH value | 5.5-6.5 |
Microbiological indicator should meet table 3 regulation
Table 3 microbiological indicator
Detect index | Standard value | Measured value |
Total number of bacterial colonies<cfu/ml) | ≤200 | 0 |
Tool bacterium bacterium Lip river sum (cfu/ml) | ≤100 | 0 |
Coliform | Must not detect | Do not detect |
Candida albicans | Must not detect | Do not detect |
Bacillus pyocyaneus | Must not detect | Do not detect |
Hemolytic streptococcus | Must not detect | Do not detect |
Bactericidal effect should meet table 4 regulation
Table 4 bactericidal effect
Project | Time | Sterilizing rate |
Candida albicans | 2min | 100% sterilization |
Staphylococcus aureus | 2min | 100% sterilization |
Sanitary toxicology should meet table 5 regulation
Table 5 sanitary toxicology
Project | Stimulation index | Index |
A skin irritation test | 0 | Non-stimulated |
4, coding
5, packing is divided intermediate package and big packing, intermediate package, and the cover box is adorned 20 bottles of finished products; Big packing places big carton with intermediate package, should meet the corrugated case standard, is marked with name of product, factory's name, factory site, lot number, net content, date of manufacture, shelf-life, and with description.It is a collection of to produce having a daily output of of ad eundem, Packing Sound product with same materials, therefrom randomly draws 24 bottles and stays and do sample survey.
6, warehouse-in, finished product warehouse-in is stored, and must not contact or near goods moist, that be corrosive or be easy to become damp, must not put together with deleterious chemicals and harmful substance.
Embodiment two
The clean cloudy hydrojet of preparation 10000ml
Take by weighing:
Polyhaxemethylenguanidine Hydrochloride 15g
Glycerol 20g
Radix Paeoniae Alba extract 10g
Rosemary ethereal oil 3g
Diphenhydramine 200g
Place mixer, add pure water to 10000ml, be mixed with hydrochloric polyhexamethylene guanidine 0.146wt%, glycerol 0.195wt%, Radix Paeoniae Alba extract 0.097wt%, rosemary ethereal oil 0.029wt%, the clean cloudy hydrojet of diphenhydramine 1.95wt%, clean cloudy hydrojet fill of the present invention in the hydrojet bottle of the system of moulding, and is sealed up jet head and made sanitary hydrojet for cleaning vagina.
Preparation method is identical with embodiment one.
Claims (2)
1, a kind of sanitary hydrojet for cleaning vagina comprises clean cloudy hydrojet and hydrojet bottle, it is characterized in that described clean cloudy hydrojet is by following drug component and percentage by weight:
Polyhaxemethylenguanidine Hydrochloride 0.146-0.15wt%,
Glycerol 0.195-0.2wt%,
Radix Paeoniae Alba extract 0.097-0.1wt%,
Rosemary ethereal oil 0.029-0.03wt%,
Diphenhydramine 1.95-2.0wt%,
Be hybridly prepared into aqueous solution by above-mentioned component and get clean cloudy hydrojet of the present invention.
2, the preparation method of a kind of sanitary hydrojet for cleaning vagina according to claim 1, its feature comprises the steps:
Step 1
Prepare clean cloudy hydrojet, take by weighing Polyhaxemethylenguanidine Hydrochloride, glycerol, Radix Paeoniae Alba extract, rosemary ethereal oil and diphenhydramine and pure water is mixed into aqueous solution by clean cloudy hydrojet component;
Step 2
In moulding system hydrojet bottle, and encapsulation goes up jet head with the clean cloudy hydrojet fill of preparation, sanitary hydrojet for cleaning vagina of the present invention.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNA2009100107652A CN101502569A (en) | 2009-03-20 | 2009-03-20 | Sanitary hydrojet for cleaning vagina and preparation method |
Applications Claiming Priority (1)
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CNA2009100107652A CN101502569A (en) | 2009-03-20 | 2009-03-20 | Sanitary hydrojet for cleaning vagina and preparation method |
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Publication Number | Publication Date |
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CN101502569A true CN101502569A (en) | 2009-08-12 |
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Application Number | Title | Priority Date | Filing Date |
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CNA2009100107652A Pending CN101502569A (en) | 2009-03-20 | 2009-03-20 | Sanitary hydrojet for cleaning vagina and preparation method |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106214926A (en) * | 2016-07-29 | 2016-12-14 | 腾科宝迪(厦门)生物科技有限公司 | A kind of nasal spray and preparation method thereof |
CN111939172A (en) * | 2020-03-06 | 2020-11-17 | 吉林云飞医药有限公司 | Disinfectant for women and preparation method thereof |
-
2009
- 2009-03-20 CN CNA2009100107652A patent/CN101502569A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106214926A (en) * | 2016-07-29 | 2016-12-14 | 腾科宝迪(厦门)生物科技有限公司 | A kind of nasal spray and preparation method thereof |
CN111939172A (en) * | 2020-03-06 | 2020-11-17 | 吉林云飞医药有限公司 | Disinfectant for women and preparation method thereof |
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Application publication date: 20090812 |