CN106420938B - A kind of Chinese medicine composition and preparation method thereof for treating oral inflammation and pharyngitis - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating oral inflammation and pharyngitis Download PDFInfo
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- CN106420938B CN106420938B CN201611166098.3A CN201611166098A CN106420938B CN 106420938 B CN106420938 B CN 106420938B CN 201611166098 A CN201611166098 A CN 201611166098A CN 106420938 B CN106420938 B CN 106420938B
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- aqua aromatica
- pharyngitis
- aromatica
- aqua
- chinese medicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Abstract
The present invention relates to a kind of Chinese medicine compositions and preparation method thereof for treating oral inflammation and pharyngitis, it is made of cloves aqua aromatica, cortex cinnamomi aqua aromatica, lavender aqua aromatica, rosemary aqua aromatica etc., it with degerming, anti-inflammatory, eliminates bad breath, while can also play the role for the treatment of throat swelling and pain, pharyngitis.It is characterized in that the mass percentage of each ingredient are as follows: cloves aqua aromatica: 30%-70%, cortex cinnamomi aqua aromatica: 5%-50%, lavender aqua aromatica 0.1%-5%, rosemary aqua aromatica: 0.1%-5%.The dosage form being related to is spray, mouthwash, oral solution, lozenge and granule etc., preferably spray or mouthwash.Its spray is the preparation method comprises the following steps: cloves aqua aromatica, rosemary aqua aromatica, cortex cinnamomi aqua aromatica, lavender aqua aromatica are uniformly mixed.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition more particularly to a kind of Chinese medicine composition for treating oral inflammation and pharyngitis and
Preparation method.
Background technique
Since haze exists on a large scale Chinese, the patient for suffering from sphagitis is caused to increase year by year.Sphagitis is pharyngeal mucosa,
The inflammation of submucous tissue, as clinical frequently-occurring disease, oneself seriously threatens and influences the health of people.Sphagitis, be by
A kind of disease caused by bacterium can be divided into acute laryngopharyngitis and two kinds of pharyngo-laryngitis chronica.Acpuei pharyngitis symptom feature is pharyngeal red
Swollen, scorching hot pain has blocking to feel in larynx, and it is unfavorable to swallow pain, hoarseness, often there is a fever, aversion to cold, red tongue body, the mostly floating number of arteries and veins,
These are mostly be it is hot and suffocating due to having in patient, feel exopathogen again, attack within and outside caused by throat.Chronic pharyngitis is mainly divided following several
Class: one is chronic simple pharyngitis and chronic hypertrophic pharyngitis, and there are also atrophic or pharyngitis siccas.Symptom includes pharyngeal
Various senses of discomfort are had, are itched, burning heat sensation, hypodynia etc. since secretion irritates releasing stimulus cough, but also can cause
Tympanitis, nasosinusitis, laryngitis, tracheobronchitis and pneumonia, acute festering type pharyngitis even can complicated with acute when serious
Ephritis, rheumatic fever and septicemia etc..Cardinal symptom feature is foreign body in pharynx sense, itches and makees cough, no phlegm, sound or hoarse or change
It adjusts.Stomatitis is buccal, tongue side, palate, and ulcer occurs for gums etc., and surrounding redness is had a pain, and ulceration has erosion, seriously affects trouble
The quality of life of person.Therefore how obtaining one kind, effectively, conveniently rapidly the preparation for the treatment of pharyngitis and stomatitis is that we are present
There are the problem of.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicine compositions for treating oral inflammation and pharyngitis, it is by cloves fragrance
Water, cortex cinnamomi aqua aromatica, rosemary aqua aromatica, lavender aqua aromatica composition.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine composition for treating oral inflammation and pharyngitis, the component comprising following weight proportion: cloves aqua aromatica
30%-70%, cortex cinnamomi aqua aromatica 5%-50%, rosemary aqua aromatica 0.1%-5%, lavender aqua aromatica 0.1%-5%.
Percentage in the present invention refers both to mass percent.
Cloves aqua aromatica is cloves using distillate remaining after extraction by steam distillation separation volatile clove oil.
Cortex cinnamomi aqua aromatica is cortex cinnamomi using distillate remaining after extraction by steam distillation separation Cortex Cinnamomi volatile oil.
Rosemary aqua aromatica is rosemary using distillation remaining after extraction by steam distillation separation rosemary volatile oil
Liquid.
Lavender aqua aromatica is lavender using distillation remaining after extraction by steam distillation separation lavenderessential oil
Liquid.
The dosage form of Chinese medicine composition of the present invention can be it is in the prior art any, such as spray, mouthwash, mouth
Take liquid etc..
Wherein spray and mouthwash preparation process are as follows: by cloves aqua aromatica 30%-70%, cortex cinnamomi aqua aromatica 5%-
50%, lavender aqua aromatica 0.1%-5%, rosemary aqua aromatica 0.1%-5% are mixed and were both obtained.
Cloves aqua aromatica in the present invention, which has, controls stomach cold pain swollen, hiccup, vomiting and diarrhoea, numbness pain, colic, halitosis, the function of toothache
Effect.Rosemary aqua aromatica in the present invention has affection of exogenous wind-heat；Headache and hot eyes；Pharyngalgia；It has a toothache；The effect of skin wind-heat.Cortex cinnamomi
Aqua aromatica has antibacterial, anti-inflammatory, fragrant stomach invigorating, wind dispelling and other effects.There is lavender aqua aromatica anti-inflammatory, antipyretic, antibacterial, reinforcement to exempt from
The effect of epidemic disease function.
Cloves, cortex cinnamomi are often used as treatment pharyngitis with the volatile oil that it is extracted at present, and simultaneously by extraction by steam distillation
Distillate after separation volatile oil is usually discarded, the reasonable utilization being deficient in resources, so that natural resources of Chinese medicinal materials wastes significantly.And mesh
Preceding more literature research discovery cloves aqua aromatica, cortex cinnamomi aqua aromatica have the function of it is stronger sterilize, be anti-inflammatory, and since its is certain
The saturated solution of soluble small molecular, therefore there is more preferable action speed and lower irritation, and make surfactant
Dosage is less, can greatly save the cost of product.Therefore from the angle of resources effective utilization, this patent is with cloves, meat
Osmanthus, rosemary, lavender separate the distillate after volatile oil by steam distillation as main raw material, have safety,
Efficiently, the features such as environmentally friendly, at low cost.
Detailed description of the invention
Fig. 1 is the bacterium colony figure after the first pipe physiological saline inoculated and cultured, and wherein a is that traditional mouthwash the first pipe of experimental group is raw
Bacterium colony figure after managing salt water inoculated and cultured, b are the inoculation of mouthwash experimental group the first pipe physiological saline made from the embodiment of the present invention 1
Bacterium colony figure after culture.
Fig. 2 is the bacterium colony figure after the second pipe physiological saline inoculated and cultured, and wherein a is that traditional mouthwash the second pipe of experimental group is raw
Bacterium colony figure after managing salt water inoculated and cultured, b are the inoculation of mouthwash experimental group the second pipe physiological saline made from the embodiment of the present invention 1
Bacterium colony figure after culture.
Specific embodiment
Embodiment 1: prepare mouthwash preparation process: by cloves aqua aromatica: 50%, cortex cinnamomi aqua aromatica: 40%, rosemary is fragrant
Perfume: 5%, lavender aqua aromatica: 5% is uniformly mixed.
The measurement of oral bacteria clearance rate
Every bit test person is first gargled with clear water after just feeding when test, method: clear water being contained in mouth, is agitated
Two cheeks and lip contact clear water can sufficiently with tooth, gum in oral cavity, and each portion in oral cavity is repeatedly rinsed using waterpower
Position, thus dispose as far as possible the alveole ditch for remaining in tooth, diastema, gum, lip buccal groove etc. swill and
Soft dirt.The first pipe is first spat into containing 1min is gargled with 20mL physiological saline.It is spaced 1min, it is real with traditional mouthwash and the present invention respectively
Mouthwash made from example 1 is applied, the mouthwash in aforementioned manners containing about 10mL gargles 1min, then is contained with 20ml physiological saline and gargled
1min spits into the second pipe, and two pipe samples stand 10min, takes its appropriate dilution inoculation plate respectively, pours into ordinary nutrient agar
And mix, in 37 DEG C of incubation 48h, both observations fungistatic effect.
Experimental result: after the mouthwash made from the embodiment 1, culture medium clump count is considerably less than tradition and gargles
Water illustrates that mouthwash fungistatic effect produced by the present invention is more preferable.
Embodiment 2: pharyngitis is sprayed preparation process: by cloves aqua aromatica: 49.9%, cortex cinnamomi aqua aromatica: 49.9%, rosemary
Aqua aromatica: 0.1%, lavender aqua aromatica: 0.1% is uniformly mixed.
The local stimulation test of the present invention for treating anxious principal characteristic pharyngitis spray: 2.5kg healthy rabbits 3 are selected, throat
Apply pharyngitis spray in position.Disposable large dosage is sprayed on oral cavity and bottleneck throat, observes and records for 24 hours, local anti-after 72h
Answer phenomenon.The result shows that: medication is showed no rubescent, dermexanthesis, bubble etc. for 24 hours, after 72h and locally irritates phenomenon, illustrates that this preparation does not have
There is Acute irritation test；In addition it respectively takes the daily oral cavity of 3 rabbit and throat to spray 3 times, is observed after continuous spray 14d, still not
Hair is shown in that rubescent, dermexanthesis, bubble etc. locally irritate phenomenon.Illustrate that said preparation irritates reaction without chronic cumulative bad.
Minimum bacteriostatic activity concentration experiment (MIC) measurement
Measurement pharyngitis spray is to staphylococcus aureus, staphylococcus epidermis, staphylococcus albus, beta hemolysis respectively
Property streptococcus, streptococcus pneumonia, Klebsiella Pneumoniae, escherichia coli, pseudomonas aeruginosa, Candida albicans MIC
Using the spraying MIC of equivalent Dilution pharyngitis.It is 10 by bacterium diluted concentration11~1012Bacterium (the spore of cfu/L
Son) suspension.1 column hole is added in 200 μ L meat soups (nutrient broth or serum broth) and does blank control, by 100 μ L meat soup (nutrient meats
Soup or serum broth) and 100 μ L pharyngitis be added to the 2nd column by spraying, the meat soup (nutrient broth or serum broth) of 100 μ L is added
To 3~11 column.After the pharyngitis of the 2nd column is spraying and meat soup (nutrient broth or serum broth) carries out mixing piping and druming, its gained is taken
100 μ L of suspension is added to the 3rd hole, then takes the 3rd column sky 100 μ L of mixed liquor to be added the 4th and arranges hole, is successively diluted to the by this method
11 column remove the 100 μ L of suspension that takes out in the 11st column, both the pharyngitis of concentration a series of is sprayed culture solution.By 100 μ L
1011~1012The bacterium of cfu/L or fungi (spore) suspension are added to 2~11 each holes of column, then plus 100 μ L culture solutions to 4 holes
For control group, the 12nd column add the 10 of 200 μ L11~1012The bacterium of cfu/L or fungi (spore) suspension, are set as negative control group.
The 20 μ l of resazurin solution of 0.25g/L is added into all holes, respectively cultivates its Micro-Organism Culture Dish for 24 hours at 37 DEG C, fungi
48~72h is cultivated at 28 DEG C, observation is as a result, determine minimal inhibitory concentration.
The spraying minimum bacteriostatic activity concentration to various bacteriums of the pharyngitis of the present invention of table 1
| Strain | MIC |
| Staphylococcus aureus | 64 |
| Staphylococcus epidermis | 32 |
| Staphylococcus albus | 32 |
| Beta hemolytic streptococcus | 128 |
| Streptococcus pneumonia | 64 |
| Klebsiella Pneumoniae | 128 |
| Escherichia coli | 32 |
| Pseudomonas aeruginosa | 64 |
| Candida albicans | 128 |
The result shows that pharyngitis spray has preferable killing effect to the common strain of acute/chronic pharyngitis.
Claims (7)
1. a kind of Chinese medicine composition for treating oral inflammation and pharyngitis, it is characterised in that: by cloves aqua aromatica, cortex cinnamomi aqua aromatica,
Rosemary aqua aromatica, lavender aqua aromatica form, and specific weight proportion is one of (1) or (2):
(1) cloves aqua aromatica: 50%, cortex cinnamomi aqua aromatica: 40%, rosemary aqua aromatica: 5%, lavender aqua aromatica: 5%；
(2) cloves aqua aromatica: 49.9%, cortex cinnamomi aqua aromatica: 49.9%, rosemary aqua aromatica: 0.1%, lavender aqua aromatica:
0.1%.
2. a kind of Chinese medicine composition for treating oral inflammation and pharyngitis according to claim 1, it is characterized in that: cloves fragrance
Water is distillate remaining after separating volatile clove oil using extraction by steam distillation.
3. a kind of Chinese medicine composition for treating oral inflammation and pharyngitis according to claim 1, it is characterized in that: cortex cinnamomi fragrance
Water is distillate remaining after separating Cortex Cinnamomi volatile oil using extraction by steam distillation.
4. a kind of Chinese medicine composition for treating oral inflammation and pharyngitis according to claim 1, it is characterized in that: rosemary virtue
Perfume is distillate remaining after separating rosemary volatile oil using extraction by steam distillation.
5. a kind of Chinese medicine composition for treating oral inflammation and pharyngitis according to claim 1, it is characterized in that: lavender virtue
Perfume is distillate remaining after separating lavenderessential oil using extraction by steam distillation.
6. a kind of Chinese medicine composition for treating oral inflammation and pharyngitis according to claim 1, it is characterised in that: described group
The dosage form for closing object is spray or mouthwash.
7. a kind of Chinese medicine composition for treating oral inflammation and pharyngitis according to claim 6, it is characterised in that: the spray
The preparation process of mist agent or mouthwash is to mix cloves aqua aromatica, cortex cinnamomi aqua aromatica, lavender aqua aromatica, rosemary aqua aromatica
It closes.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611166098.3A CN106420938B (en) | 2016-12-16 | 2016-12-16 | A kind of Chinese medicine composition and preparation method thereof for treating oral inflammation and pharyngitis |
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|---|---|---|---|
| CN201611166098.3A CN106420938B (en) | 2016-12-16 | 2016-12-16 | A kind of Chinese medicine composition and preparation method thereof for treating oral inflammation and pharyngitis |
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| CN106420938B true CN106420938B (en) | 2019-11-12 |
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| CN112516227A (en) * | 2020-11-27 | 2021-03-19 | 南方医科大学 | Compound essential oil for enhancing immunity and application thereof |
| CN114432201B (en) * | 2022-02-21 | 2023-08-15 | 罗定市亿绿实业投资有限公司 | Ramulus Cinnamomi mouthwash raw material composition and application thereof |
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| Title |
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| 如烟整理的我家16种纯露功效大总结大家可以借鉴;xiaomeidanmo;《http://club.1688.com/article/58505809.htm》;20150418;第1-2页，尤其是第2页紫丁香纯露部分 * |
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Effective date of registration: 20221226 Address after: Building 2, No. 168, Huangqin Road, Zhihe street, Pengzhou, Chengdu, Sichuan 610000 Patentee after: Sichuan Tianfu fragrant health Technology Research Institute Co.,Ltd. Address before: 330004 No. 1088, Meiling Avenue, Wanli District, Nanchang City, Jiangxi Province Patentee before: JIANGXI University OF TRADITIONAL CHINESE MEDICINE |
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