CN106420938A - Traditional Chinese medicine composition for curing oral inflammation and pharyngitis and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for curing oral inflammation and pharyngitis and preparation method of traditional Chinese medicine composition Download PDFInfo
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- CN106420938A CN106420938A CN201611166098.3A CN201611166098A CN106420938A CN 106420938 A CN106420938 A CN 106420938A CN 201611166098 A CN201611166098 A CN 201611166098A CN 106420938 A CN106420938 A CN 106420938A
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- aromatic water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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Abstract
The invention relates to traditional Chinese medicine composition for curing oral inflammation and pharyngitis and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from aromatic water of clove, aromatic water of cinnamon, aromatic water of lavender, aromatic water of rosemary and the like, has the effects of removing bacteria, diminishing inflammation and removing ozostomia, and also plays roles in treating swollen sore throat and pharyngitis. The traditional Chinese medicine composition is characterized by be prepared from the following ingredients in percentage by mass: 30%-70% of aromatic water of clove, 5%-50% of aromatic water of cinnamon, 0.1%-5% of aromatic water of lavender and 0.1%-5% of aromatic water of rosemary. The related dosage form is a spray, a mouthwash, an oral liquid, buccal tablets and particles, preferably, the spray or the mouthwash. A preparation method of the spray comprises mixing of the aromatic water of clove, the aromatic water of cinnamon, the aromatic water of lavender and the aromatic water of rosemary evenly.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, more particularly, to a kind of Chinese medicine composition treating oral inflammation and pharyngitis and
Its preparation method.
Background technology
Because haze exists on a large scale in China, the patient suffering from pharyngolaryngitis is led to increase year by year.Pharyngolaryngitis are pharyngeal mucosas,
The inflammation of submucous tissue, as clinical frequently-occurring disease, oneself seriously threatens and has influence on the healthy of people.Pharyngolaryngitis, be by
A kind of bacterial disease, can be divided into acute pharyngolaryngitises and two kinds of chronic pharyngolaryngitiss.Acute pharyngitises symptom feature is pharyngeal red
Swollen, scorching hot pain, there is blocking sense in larynx, it is unfavorable to swallow pain, hoarseness, often have a heating, aversion to cold, red tongue, floating number more than arteries and veins,
These are mostly to be hot and suffocating due to having in patient, feel exopathogen again, attacks within and outside and causes in throat.Chronic pharyngitiss are mainly divided following several
Class:One is chronic simple pharyngitiss and chronic hypertrophic pharyngitiss, also atrophic or pharyngitis sicca.Symptom includes pharyngeal
It is painted with various senses of discomfort, itch, burning sensation, hypodynia etc., because secretions irritate releasing stimuluss cough, but also in causing
Otitis, sinusitis, laryngitis, tracheobronchitis and pneumonia, acute clothes property mouth, even can complicated with acute kidney when serious because of inflammation
Inflammation, rheumatic fever and septicemia etc..Cardinal symptom feature is foreign body in pharynx sense, itches and coughs, no expectorant, sound hoarse or modified tone.
Stomatitis are buccal, tongue side, palate, and gums etc. occurs ulcer, and surrounding redness is had a pain, and ulceration has erosion, has a strong impact on patient
Quality of life.Therefore how to obtain a kind of effective, convenient pharyngitis and the preparation of stomatitis of rapidly treating is that we deposit now
Problem.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating oral inflammation and pharyngitis, it is by Flos Caryophylli fragrance
Water, Cortex Cinnamomi Aromatic water, Herba Rosmarini Officinalis Aromatic water, lavandula angustifolia Aromatic water composition.
The present invention is achieved by the following technical solutions：
A kind of Chinese medicine composition treating oral inflammation and pharyngitis, comprises the component of following weight proportion：Flos Caryophylli Aromatic water
30%-70%, Cortex Cinnamomi Aromatic water 5%-50%, Herba Rosmarini Officinalis Aromatic water 0.1%-5%, lavandula angustifolia Aromatic water 0.1%-5%.
Percent in the present invention refers both to mass percent.
Flos Caryophylli Aromatic water adopts remaining distillate after extraction by steam distillation separation Flos Caryophylli volatile oil for Flos Caryophylli.
Cortex Cinnamomi Aromatic water adopts remaining distillate after extraction by steam distillation separation Cortex Cinnamomi volatile oil for Cortex Cinnamomi.
Herba Rosmarini Officinalis Aromatic water adopts remaining distillation after extraction by steam distillation separation Herba Rosmarini Officinalis volatile oil for Herba Rosmarini Officinalis
Liquid.
Lavandula angustifolia Aromatic water adopts remaining distillation after extraction by steam distillation separation lavenderessential oil for lavandula angustifolia
Liquid.
The dosage form of Chinese medicine composition of the present invention can be of the prior art any one, such as spray, collutory, mouth
Take liquid etc..
Wherein spray and collutory preparation technology are as follows：By Flos Caryophylli Aromatic water 30%-70%, Cortex Cinnamomi Aromatic water 5%-
50%th, lavandula angustifolia Aromatic water 0.1%-5%, Herba Rosmarini Officinalis Aromatic water 0.1%-5%, mixes and both obtained.
Flos Caryophylli Aromatic water in the present invention has controls cold syndrome of the stomach pain with distension, singultuss, vomiting and diarrhoea, arthralgia pain, colic, halitosis, the work(of toothache
Effect.Herba Rosmarini Officinalis Aromatic water in the present invention has affection due to external wind and heat；Hot eyes of having a headache；Pharyngalgia；Have a toothache；Effect of skin wind heat.Cortex Cinnamomi
Aromatic water has the effects such as antibacterial, antiinflammatory, fragrant stomach invigorating, wind dispelling.Lavandula angustifolia Aromatic water have antiinflammatory, antipyretic, antibacterial, strengthen exempt from
Epidemic disease function acts on.
Flos Caryophylli, Cortex Cinnamomi commonly use the volatile oil of its extraction as treatment pharyngitis at present, and pass through extraction by steam distillation simultaneously
Separate volatile oil after distillate be usually discarded, be deficient in resources reasonable using so that natural resources of Chinese medicinal materials wastes significantly.And mesh
Front more literature research finds that Flos Caryophylli Aromatic water, Cortex Cinnamomi Aromatic water have the effect of stronger sterilization, antiinflammatory, and because it is some
The saturated solution of soluble small molecular, therefore has more preferable onset speed and lower zest, and makes surfactant
Consumption is less, can greatly save the cost of product.Therefore from the angle of resources effective utilization, this patent is with Flos Caryophylli, meat
Osmanthus, Herba Rosmarini Officinalis, distillate after steam distillation separation volatile oil for the lavandula angustifolia as main raw material, have safety,
Efficiently, the features such as environmental protection, low cost.
Brief description
Fig. 1 is the bacterium colony figure after first pipe normal saline inoculated and cultured, and wherein a is traditional collutory experimental group first pipe life
Bacterium colony figure after reason saline inoculated and cultured, b is the collutory experimental group first pipe normal saline inoculation that the embodiment of the present invention 1 is obtained
Bacterium colony figure after culture.
Fig. 2 is the bacterium colony figure after second pipe normal saline inoculated and cultured, and wherein a is traditional collutory experimental group second pipe life
Bacterium colony figure after reason saline inoculated and cultured, b is the collutory experimental group second pipe normal saline inoculation that the embodiment of the present invention 1 is obtained
Bacterium colony figure after culture.
Specific embodiment
Embodiment 1：Prepare collutory preparation technology：By Flos Caryophylli Aromatic water：50%th, Cortex Cinnamomi Aromatic water：40%th, Herba Rosmarini Officinalis virtue
Perfume：5%th, lavandula angustifolia Aromatic water：5% mix homogeneously.
Oral cavity bacterium clearance rate measures
During test, every bit test person, all after just taking food, is first gargled with clear water, method:Clear water is contained in mouth, agitates
Two cheeks and lip, are made clear water can fully be contacted with tooth, gingiva in oral cavity, and repeatedly rinse each portion of oral cavity using waterpower
Position, thus dispose as far as possible the food debriss remaining in the alveole ditch of tooth, diastema, gingiva, lip buccal groove etc. and
Soft dirt.First with 20mL normal saline rinsing the mouth 1min, spit into first pipe.Interval 1min, uses traditional collutory and the present invention real respectively
Apply the mouthwash that example 1 is obtained, 1min gargled by the collutory containing about 10mL in aforementioned manners, then with 20ml normal saline rinsing the mouth
1min, spits into second pipe, two pipe sample standing 10min, takes its suitable diluent to inoculate plate respectively, pours into ordinary nutrient agar
And mix, in 37 DEG C of incubation 48h, observe the two fungistatic effect.
Experimental result：Through, after the mouthwash that embodiment 1 is obtained, its culture medium clump count is considerably less than tradition and gargles
Water, illustrates that the collutory fungistatic effect that the present invention is obtained is more preferable.
Embodiment 2：Pharyngitis spraying preparation technology：By Flos Caryophylli Aromatic water：49.9%th, Cortex Cinnamomi Aromatic water：49.9%th, Herba Rosmarini Officinalis
Aromatic water：0.1%th, lavandula angustifolia Aromatic water：0.1% mix homogeneously.
The local stimulation test for the treatment of urgency principal characteristic pharyngitis spray of the present invention:Select 2.5kg healthy rabbits 3, throat
Pharyngitis spray is applied at position.Disposably heavy dose is sprayed on oral cavity and bottleneck throat, observes and record 24h, the reaction of local after 72h
Phenomenon.Result shows:Medication 24h, is showed no rubescent, dermexanthesis, blister etc. local and irritates phenomenon, illustrate that this preparation does not have after 72h
Acute irritation test；In addition respectively take the daily oral cavity of 3 rabbit and throat to spray 3 times, observe after continuous spray 14d, still all do not send out
See that the rubescent, local such as dermexanthesis, blister irritates phenomenon.Illustrate that the no chronic cumulative bad of said preparation irritates reaction.
Minimum bacteriostatic activity concentration experiment (MIC) measures
Measure pharyngitis spray respectively to staphylococcus aureuses, staphylococcus epidermidiss, Staphylococcus albus, beta hemolysis
Property streptococcus, streptococcus pneumoniae, Klebsiella Pneumoniae, escherichia coli, Pseudomonas aeruginosa, the MIC of Candida albicans
MIC using the spraying of equivalent Dilution pharyngitis.Antibacterial diluted concentration is 1011～1012Bacterium (the spore of cfu/L
Son) suspension.200 μ L meat soups (nutrient broth or serum broth) are added 1 row hole to do blank, by 100 μ L meat soup (nutrient meat
Soup or serum broth) and the spraying of 100 μ L pharyngitis be added to the 2nd row, the meat soup (nutrient broth or serum broth) of 100 μ L is added
To 3～11 row.The pharyngitis spraying of the 2nd row and meat soup (nutrient broth or serum broth) are carried out, after mixing piping and druming, taking its gained
Suspension 100 μ L is added to the 3rd hole, then takes the empty mixed liquor 100 μ L of the 3rd row to add the 4th row hole, is diluted to the successively by this method
11 row, by the 11st arrange in take out suspension 100 μ L go, both a series of concentration pharyngitis spray culture fluid.By 100 μ L
1011～1012The antibacterial of cfu/L or funguses (spore) suspension are added to 2～11 each holes of row, then plus 100 μ L culture fluid to 4 holes
For matched group, the 10 of the 12nd row plus 200 μ L11～1012The antibacterial of cfu/L or funguses (spore) suspension, are set to negative control group.
Add the resazurin solution 20 μ l of 0.25g/L to all in the holes, respectively its Micro-Organism Culture Dish is cultivated at 37 DEG C 24h, funguses
Cultivate 48～72h, observed result at 28 DEG C, determine minimal inhibitory concentration.
The minimum bacteriostatic activity concentration to various antibacterials for the table 1 pharyngitis of the present invention spraying
| Strain | MIC |
| Staphylococcus aureuses | 64 |
| Staphylococcus epidermidiss | 32 |
| Staphylococcus albus | 32 |
| Beta hemolytic streptococcuss | 128 |
| Streptococcus pneumoniae | 64 |
| Klebsiella Pneumoniae | 128 |
| Escherichia coli | 32 |
| Pseudomonas aeruginosa | 64 |
| Candida albicans | 128 |
Result shows, pharyngitis spray all has preferable killing action to the common strain of acute/chronic pharyngitis.
Claims (9)
1. a kind of Chinese medicine composition treating oral inflammation and pharyngitis it is characterised in that：It is by Flos Caryophylli Aromatic water, Cortex Cinnamomi fragrance
Water, Herba Rosmarini Officinalis Aromatic water, lavandula angustifolia Aromatic water form.
2. a kind of Chinese medicine composition treating oral inflammation and pharyngitis according to claim 1, it is characterized by：Comprise following
The component of weight proportion：Flos Caryophylli Aromatic water：30%-70%, Cortex Cinnamomi Aromatic water：5%-50%, Herba Rosmarini Officinalis Aromatic water：0.1%-
5%th, lavandula angustifolia Aromatic water 0.1%-5%.
3. a kind of Chinese medicine composition treating oral inflammation and pharyngitis according to claim 1, it is characterized by：Flos Caryophylli fragrance
Water is using remaining distillate after extraction by steam distillation separation Flos Caryophylli volatile oil.
4. a kind of Chinese medicine composition treating oral inflammation and pharyngitis according to claim 1, it is characterized by：Cortex Cinnamomi fragrance
Water is using remaining distillate after extraction by steam distillation separation Cortex Cinnamomi volatile oil.
5. a kind of Chinese medicine composition treating oral inflammation and pharyngitis according to claim 1, it is characterized by：Herba Rosmarini Officinalis virtue
Perfume is using remaining distillate after extraction by steam distillation separation Herba Rosmarini Officinalis volatile oil.
6. a kind of Chinese medicine composition treating oral inflammation and pharyngitis according to claim 1, it is characterized by：Lavandula angustifolia virtue
Perfume is using remaining distillate after extraction by steam distillation separation lavenderessential oil.
7. a kind of Chinese medicine composition treating oral inflammation and pharyngitis according to claim 1 it is characterised in that：Described medicine
Compositions are spray, collutory, oral liquid, and are not limited to above form of medication.
8. a kind of Chinese medicine composition treating oral inflammation and pharyngitis according to claim 2 it is characterised in that：Described group
Compound is spray, collutory.
9. a kind of Chinese medicine composition treating oral inflammation and pharyngitis according to claim 2 it is characterised in that：Described spray
Mist agent and collutory preparation technology are as follows：Flos Caryophylli Aromatic water：30%-70%, Cortex Cinnamomi Aromatic water：5%-50%, lavandula angustifolia fragrance
Water 0.1%-5%, Herba Rosmarini Officinalis Aromatic water：0.1%-5% mixes and both obtained.
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| CN201611166098.3A CN106420938B (en) | 2016-12-16 | 2016-12-16 | A kind of Chinese medicine composition and preparation method thereof for treating oral inflammation and pharyngitis |
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| CN201611166098.3A CN106420938B (en) | 2016-12-16 | 2016-12-16 | A kind of Chinese medicine composition and preparation method thereof for treating oral inflammation and pharyngitis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516227A (en) * | 2020-11-27 | 2021-03-19 | 南方医科大学 | Compound essential oil for enhancing immunity and application thereof |
| CN114432201A (en) * | 2022-02-21 | 2022-05-06 | 清远中大创新药物研究中心 | Cassia twig mouthwash raw material composition and application thereof |
-
2016
- 2016-12-16 CN CN201611166098.3A patent/CN106420938B/en active Active
Non-Patent Citations (4)
| Title |
|---|
| （法）范思提等: "《薰衣草的妙用》", 30 November 2013, 上海科学技术出版社 * |
| XIAOMEIDANMO: "如烟整理的我家16种纯露功效大总结 大家可以借鉴", 《HTTP://CLUB.1688.COM/ARTICLE/58505809.HTM》 * |
| 朵琳出版部: "《四季泡澡方》", 31 May 2009, 河南科学技术出版社 * |
| 简芝妍: "《天然香草健康疗法》", 31 May 2005, 河南科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112516227A (en) * | 2020-11-27 | 2021-03-19 | 南方医科大学 | Compound essential oil for enhancing immunity and application thereof |
| CN114432201A (en) * | 2022-02-21 | 2022-05-06 | 清远中大创新药物研究中心 | Cassia twig mouthwash raw material composition and application thereof |
| CN114432201B (en) * | 2022-02-21 | 2023-08-15 | 罗定市亿绿实业投资有限公司 | Ramulus Cinnamomi mouthwash raw material composition and application thereof |
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Effective date of registration: 20221226 Address after: Building 2, No. 168, Huangqin Road, Zhihe street, Pengzhou, Chengdu, Sichuan 610000 Patentee after: Sichuan Tianfu fragrant health Technology Research Institute Co.,Ltd. Address before: 330004 No. 1088, Meiling Avenue, Wanli District, Nanchang City, Jiangxi Province Patentee before: JIANGXI University OF TRADITIONAL CHINESE MEDICINE |