CN107242983A - A kind of mouthwash of the flavones containing folium artemisiae argyi and preparation method thereof - Google Patents
A kind of mouthwash of the flavones containing folium artemisiae argyi and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention belongs to daily use chemicals nursing materials field, and in particular to a kind of mouthwash of flavones containing folium artemisiae argyi and preparation method thereof, the mouthwash is mainly made up of following component and its parts by weight：90 95 parts of 24 parts of folium artemisiae argyi flavones, 0.1 0.3 parts of danshensu, 0.1 0.3 parts of plant enzyme, 0.5 1 parts of antiseptic, 12 parts of APG, 0.05 0.1 parts of sodium carboxymethylcellulose, 0.4 0.6 parts of dipotassium glycyrrhizinate, 0.3 0.5 parts of vitamin C, 0.2 0.4 parts of sodium chloride and water, present component safety, the reasonable science of compatibility, with good antiphlogistic antibacterial effect, and it can effectively solve the oral problems such as halitosis, swelling and aching of gum and mucous membrane of mouth.
Description
Technical field
The invention belongs to daily use chemicals nursing materials field, and in particular to a kind of mouthwash of flavones containing folium artemisiae argyi and its preparation side
Method.
Background technology
With etiquette people live in it is more and more important, people except in dressing and words focus in addition to, note
The smell of meaning in the mouth is also the pith of self-image, and oral peculiar smell easily causes the displeased of talk in daily contacts
It hurry up, the reason for wherein oral peculiar smell causes includes 1, mouth disease；2nd, intestines problem；3rd, diet problem, but cause oral cavity different
Taste most common reason is oral bacteria, and oral bacteria can cause mouth disease, further causes oral peculiar smell, is formed
Vicious circle.
The means of conventional solution oral peculiar smell are to brush teeth, toothwash or periodically carry out teeth caring, but are worked outside
When, oral cavity cleaning is not appropriate for, therefore mouthwash contains and gargled as solving the conventional means of difficult situation, and does not injure gum,
But, dental surface dirt is cleared up because mouthwash can not carry out physical friction, therefore, modern many mouthwashes add dioxygens
The antimicrobial component such as water or chlorohexidene, but hydrogen peroxide easily injures tooth, chlorohexidene can raise blood pressure, and then increase heart
Disease, the probability of apoplexy.Therefore, the development trend that natural security elements are present mouthwashes is added.
Publication No. CN106491452A Chinese patent application discloses a kind of oral cavity nursing agent and preparation method thereof, by
Following mass fraction formula components composition：10-20 parts of Thymol, 14-16 parts of cinnamon oil, 6-8 parts of curcumin, menthol 7-9
Part, 3-5 parts of Tea Polyphenols, 6-8 parts of eucalyptus oil, 5-7 parts of Blumea oil, 3-7 parts of caryophyllus oil, 5-7 parts of creatine, 5-7 parts of Ilex Latifolia Thunb, Chinese ilex
Oily 6-10 parts, 2-3 parts of salt, the invention has the characteristics of composing wide antibacterial, efficiently quick effect, safety non-toxic, and it is fragrant to combine mouth
The advantage of the oral care products such as sugar, mouthwash, obviates the shortcoming of traditional oral care product, work well, it is easy to carry,
Using simple.But the invention mainly uses derived essential oil, with renal toxicity, it is not recommended that entrance application.
Publication No. CN105616324A Chinese patent application disclose a kind of mouthwash containing plant formula and its
Preparation method, mouthwash includes the active component, the flavor enhancement of 1-15 mass parts and 40-95 mass parts of 0.33-40 mass parts
Water, wherein, the active component includes propolis, the CPP of 0.01-5 mass parts, the 0.1-0.5 of 0.1-8 mass parts
The Folum Ilicis extracts of mass parts, the pepper extract of 0.01-5 mass parts, the garlic P.E of 0.01-0.3 mass parts,
Tea Polyphenols, the Flos Caryophylli extract of 0.05-5 mass parts of 0.05-5 mass parts, the invention reach nursing efficacy mainly for antibacterial,
The problems such as gingivitis fundamentally can not being solved.
The content of the invention
In order to solve the deficiency of prior art presence, the invention provides a kind of mouthwash of flavones containing folium artemisiae argyi and its preparation
Method, the water constituent safety of gargling of the invention provided, has good prevention effect to oral bacteria, inflammation etc..
Technical solution of the present invention is as follows：
A kind of mouthwash of flavones containing folium artemisiae argyi, is mainly made up of following component and its parts by weight：2-4 parts of folium artemisiae argyi flavones, pellet
Join 0.1-0.3 parts of element, 0.1-0.3 parts of plant enzyme, 0.5-1 parts of antiseptic, 1-2 parts of APG, sodium carboxymethylcellulose
90-95 parts of 0.05-0.1 parts, 0.4-0.6 parts of dipotassium glycyrrhizinate, 0.3-0.5 parts of vitamin C, 0.2-0.4 parts of sodium chloride and water.
It is preferred that, the mouthwash of the flavones containing folium artemisiae argyi is made up of following component and its parts by weight：3 parts of folium artemisiae argyi flavones,
0.2 part of danshensu, 0.2 part of plant enzyme, 0.8 part of antiseptic, 1.5 parts of APG, 0.08 part of sodium carboxymethylcellulose, radix glycyrrhizae
92 parts of sour 0.5 part of dipotassium, 0.4 part of vitamin C, 0.3 part of sodium chloride and water.
APG (CAS:141464-42-8) be mouthwash of the present invention cleansing, excitant is small, easily biological drop
Solution.
Folium artemisiae argyi flavones：The Flavonoid substances in folium artemisiae argyi are extracted, with Green Tea Extract, protect enteron aisle smooth and antiallergy, suppression
Bacterium and antiviral effect, folium artemisiae argyi flavones is applied has good antibacterial and anti-inflammation functions in toothpaste.
The extracting method of folium artemisiae argyi flavones is：Fresh folium artemisiae argyi is taken, drying, crushing add the ethanol of 95% volume fraction, folium artemisiae argyi
It is 1g with ethanol material ratio:15ml, ultrasonic wave extraction 3h, takes filtrate decompression to concentrate, and freeze-drying is produced.
Danshensu：The water-soluble substances composition contained in the red sage root, with suppress platelet aggregation, anti-freezing, expansion coronary artery,
Improve the effect such as cardiac function, antiatherosclerosis, anti-oxidative damage and reducing blood lipid, the present invention is applied in mouthwash
It was found that danshensu is conducive to strengthening the antiinflammatory action of folium artemisiae argyi flavones in toothpaste, and be conducive to the pain of strong swelling and aching of gum,
With good analgesic activity.
Further, described plant enzyme is 1- by weight by papain, bromelain and kelp ferment
3：1-3：1 composition.
It is preferred that, described plant enzyme is by papain, bromelain and kelp ferment by weight being 2：2：1
Composition.
Papain, bromelain are conducive to the decomposition of protein substance in oral cavity, are conducive to breath freshening, and not
Oral mucosa can be caused to stimulate, the kelp ferment wherein in plant enzyme is conducive to the regeneration of Stomatocyte, to mucous membrane of mouth by
Damaging has good repair.
Further, described antiseptic by nisin, epsilon-polylysine hydrochloride and glycine by weight
2-4：1-3：1 composition.
It is preferred that, described antiseptic is by nisin, epsilon-polylysine hydrochloride and glycine by weight 3：
2：1 composition.Wherein nisin be it is a kind of it is efficient, nontoxic, safely, the bactericide that has no side effect；Epsilon-polylysine hydrochloric acid
Salt (CAS:28211-04-3) it is a kind of new type bactericide, glycine is matched somebody with somebody with nisin, epsilon-polylysine hydrochloride
5 uses can improve the bactericidal effect of toothpaste.
Present invention also offers the preparation method of the mouthwash of the flavones containing folium artemisiae argyi, step is：By APG, carboxylic
Sodium carboxymethylcellulose pyce, dipotassium glycyrrhizinate, danshensu, sodium chloride are put into water and are completely dissolved, and are warming up to 50-60 DEG C, stir 15-
20min, mixing speed is 100-150r/min, is then cooled to 35-45 DEG C, adds vitamin C, folium artemisiae argyi flavones, plant enzyme
And antiseptic, stir, be down to room temperature, produce.
The impaired medicine of auxiliary treatment oral mucosa is being prepared the invention also discloses the mouthwash of the flavones containing folium artemisiae argyi
In application.
Present component safety, the reasonable science of compatibility, the folium artemisiae argyi flavones contained, danshensu and plant enzyme compatibility are using having
Beneficial to the anti-inflammatory analgesic of mouth disease, and it can effectively solve the oral problems such as halitosis, swelling and aching of gum and mucous membrane of mouth.
Compared with prior art, the present invention has advantages below：(1) it is safe, present component belong to safety into
Point, burden will not be produced to internal organ by swallowing；(2) antimicrobial form：The mouthwash for the folium artemisiae argyi flavones that the present invention is provided has to oral bacteria
There are good bactericidal properties, prevent and treat the generation of carious tooth；(3) anti-inflammatory：The present invention can effectively prevent and treat oral inflammation.
Embodiment
By following examples, the present invention is further illustrated, those skilled in the art is more understood skill of the present invention
Art scheme.Present component belongs to conventional products, and wherein (specification is 20 to papain:1), (specification is bromelain
20:1) with kelp ferment (product：Kelp ferment powder) it is purchased from Xi'an Si Nuote Bioisystech Co., Ltd.
A kind of mouthwash of the flavones containing folium artemisiae argyi of embodiment 1
The mouthwash of the described flavones containing folium artemisiae argyi, is made up of following component and its parts by weight：3 parts of folium artemisiae argyi flavones, danshensu
0.2 part, 0.2 part of plant enzyme, 0.8 part of antiseptic, 1.5 parts of APG, 0.08 part of sodium carboxymethylcellulose, dipotassium glycyrrhizinate
92 parts of 0.5 part, 0.4 part of vitamin C, 0.3 part of sodium chloride and water；
Described plant enzyme is 2 by weight by papain, bromelain and kelp ferment：2：1 composition；
Described antiseptic is by nisin, epsilon-polylysine hydrochloride and glycine by weight 3：2：1 composition；
The extracting method of described folium artemisiae argyi flavones is：Fresh folium artemisiae argyi is taken, drying, crushing add the second of 95% volume fraction
Alcohol, folium artemisiae argyi is 1g with ethanol material ratio:15ml, ultrasonic wave extraction 3h, takes filtrate decompression to concentrate, and freeze-drying is produced.
The preparation method of the mouthwash of the described flavones containing folium artemisiae argyi, step is：By APG, sodium carboxymethylcellulose,
Dipotassium glycyrrhizinate, danshensu, sodium chloride are put into water and are completely dissolved, and are warming up to 55 DEG C, stir 18min, mixing speed is 130r/
Min, is then cooled to 40 DEG C, adds vitamin C, folium artemisiae argyi flavones, plant enzyme and antiseptic, stirs, be down to room temperature, i.e.,
.
A kind of mouthwash of the flavones containing folium artemisiae argyi of embodiment 2
The mouthwash of the described flavones containing folium artemisiae argyi, is made up of following component and its parts by weight：2 parts of folium artemisiae argyi flavones, danshensu
0.3 part, 0.3 part of plant enzyme, 0.5 part of antiseptic, 1 part of APG, 0.05 part of sodium carboxymethylcellulose, dipotassium glycyrrhizinate
90 parts of 0.6 part, 0.5 part of vitamin C, 0.4 part of sodium chloride and water；
Described plant enzyme is 1 by weight by papain, bromelain and kelp ferment：3：1 composition；
Described antiseptic is by nisin, epsilon-polylysine hydrochloride and glycine by weight 2：3：1 composition；
The extracting method of described folium artemisiae argyi flavones is similar to Example 1.
The preparation method of the mouthwash of the described flavones containing folium artemisiae argyi is similar to Example 1.
A kind of mouthwash of the flavones containing folium artemisiae argyi of embodiment 3
The mouthwash of the described flavones containing folium artemisiae argyi, is made up of following component and its parts by weight：4 parts of folium artemisiae argyi flavones, danshensu
0.1 part, 0.1 part of plant enzyme, 1 part of antiseptic, 2 parts of APG, 0.1 part of sodium carboxymethylcellulose, dipotassium glycyrrhizinate 0.4
Part, 0.3 part of vitamin C, 0.2 part of sodium chloride and 95 parts of water；
Described plant enzyme is 3 by weight by papain, bromelain and kelp ferment：1：1 composition；
Described antiseptic is by nisin, epsilon-polylysine hydrochloride and glycine by weight 4：1：1 composition；
The extracting method of described folium artemisiae argyi flavones is similar to Example 1.
The preparation method of the mouthwash of the described flavones containing folium artemisiae argyi is similar to Example 1.
A kind of mouthwash of the flavones containing folium artemisiae argyi of comparative example 1
The mouthwash of the described flavones containing folium artemisiae argyi, is made up of following component and its parts by weight：3.2 parts of folium artemisiae argyi flavones, plant
0.2 part of ferment, 0.8 part of antiseptic, 1.5 parts of APG, 0.08 part of sodium carboxymethylcellulose, 0.5 part of dipotassium glycyrrhizinate, dimension life
92 parts of plain C0.4 parts, 0.3 part of sodium chloride and water；
Described plant enzyme is 2 by weight by papain, bromelain and kelp ferment：2：1 composition；
Described antiseptic is by nisin, epsilon-polylysine hydrochloride and glycine by weight 3：2：1 composition；
The extracting method of described folium artemisiae argyi flavones is similar to Example 1.
The preparation method of the mouthwash of the described flavones containing folium artemisiae argyi is similar to Example 1.
Difference with embodiment 1 is, without danshensu, to increase the content of folium artemisiae argyi flavones.
A kind of mouthwash of the flavones containing folium artemisiae argyi of comparative example 2
The mouthwash of the described flavones containing folium artemisiae argyi, is made up of following component and its parts by weight：3 parts of folium artemisiae argyi flavones, danshensu
0.2 part, 0.2 part of plant enzyme, 0.8 part of antiseptic, 1.5 parts of APG, 0.08 part of sodium carboxymethylcellulose, dipotassium glycyrrhizinate
92 parts of 0.5 part, 0.4 part of vitamin C, 0.3 part of sodium chloride and water；
Described plant enzyme is 2 by weight by papain, bromelain：2 compositions；
Described antiseptic is by nisin, epsilon-polylysine hydrochloride and glycine by weight 3：2：1 composition；
The extracting method of described folium artemisiae argyi flavones is similar to Example 1.
The preparation method of the mouthwash of the described flavones containing folium artemisiae argyi is similar to Example 1.
Difference with embodiment 1 is without kelp ferment in plant enzyme.
A kind of mouthwash of the flavones containing folium artemisiae argyi of comparative example 3
The mouthwash of the described flavones containing folium artemisiae argyi, is made up of following component and its parts by weight：3 parts of folium artemisiae argyi flavones, danshensu
0.2 part, 0.2 part of plant enzyme, 0.8 part of antiseptic, 1.5 parts of APG, 0.08 part of sodium carboxymethylcellulose, dipotassium glycyrrhizinate
92 parts of 0.5 part, 0.4 part of vitamin C, 0.3 part of sodium chloride and water；
Described plant enzyme is 2 by weight by papain, bromelain and kelp ferment：2：1 composition；
Described antiseptic is by nisin and epsilon-polylysine hydrochloride by weight 3：2 compositions；
The extracting method of described folium artemisiae argyi flavones is similar to Example 1.
The preparation method of the mouthwash of the described flavones containing folium artemisiae argyi is similar to Example 1.
Difference with embodiment 1 is without glycine in antiseptic.
Test example 1, anti-inflammatory experiment
Subjects：The mouthwash of the flavones containing folium artemisiae argyi made from embodiment 1-3 and comparative example 1-3；
Test method：60 Kunming mouses, male and female half and half, 25-30 grams of body weight is randomly divided into 6 groups, every group 10 by body weight
Only, it is anesthetized with ether, 20 μ l dimethylbenzene are uniformly applied to after mouse right ear, 30min, smears and gargle in mouse right ear inflammation part
Once, continuous 6 times, left ear does not make any processing, after 4 hours by water 0.5ml, 10min, puts to death mouse, ears are cut immediately, uses
8mm card punch takes same area auricle, weighs, and calculates swelling and swelling rate；Swelling=auris dextra piece weight-left auricle weight, swells
Swollen rate=swelling/left auricle weight, averages, the results are shown in Table 1.
The influence of the mouthwash paraxylene induced mice auricle edema of table 1
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Swelling (mg) | 5.45 | 5.71 | 5.76 | 6.15 | 6.10 | 6.26 |
| Swelling rate (%) | 70.25 | 72.66 | 72.95 | 76.82 | 76.62 | 77.01 |
From table 1 it follows that 1-3 of the embodiment of the present invention has significant difference, explanation compared with comparative example 1-3 antiphlogistic effects
Mouthwash of the present invention has good anti-inflammatory effects.
Test example 2, bacteriostatic experiment
Subjects：The mouthwash and negative controls for the flavones containing folium artemisiae argyi that embodiment 1-3 is prepared with comparative example 3 be
The physiological saline of 0.9% mass fraction；
Test bacterium：Candida albicans, Streptococcus sanguis, streptococcus mutans and actinomyces viscosus；
Test method：Take 0.2ml mouthwashes instill 10ml volumes culture medium (surface area is 10cm2, 3% tryptose is big
The solid agar that beans meat soup is mixed with agar) center, Candida albicans, Streptococcus sanguis, streptococcus mutans are inoculated with respectively and are glued
Actinomyces, are placed in 37 DEG C of constant temperature incubators 24 hours, and media surface forms circular antibacterial circle, and diameter is determined respectively and is come
Antibacterial ability is evaluated, is specifically shown in Table 2.
The antibacterial loop diameter size (unit of table 2：mm)
| Group | Candida albicans | Streptococcus sanguis | Streptococcus mutans | Actinomyces viscosus |
| Embodiment 1 | 10.26 | 21.03 | 30.42 | 26.35 |
| Embodiment 2 | 9.63 | 19.56 | 28.93 | 24.45 |
| Embodiment 3 | 9.25 | 18.99 | 27.95 | 23.87 |
| Comparative example 3 | 6.51 | 15.63 | 24.39 | 20.35 |
| Negative control | 0 | 0 | 0 | 0 |
From Table 2, it can be seen that negative control physiological saline does not produce any antibacterial circle, and embodiment 1-3 and comparative example 3
Obvious antibacterial circle is generated, mouthwash has more preferable antibacterial compared with comparative example 3 wherein made from 1-3 of the embodiment of the present invention
Effect, the fungistatic effect of embodiment 1 preferably, can carious tooth effectively caused by distortion preventing streptococcus.
Test example 3, analgesic experiment
Subjects：The mouthwash and negative controls of embodiment -3 and the flavones containing folium artemisiae argyi made from comparative example 1 are 0.9%
The physiological saline of mass fraction；
Mouse hot-plate pain model：Body weight 22g or so female mice is placed on hot plate pain threshold detector, qualification mouse is screened
100 (licking metapedes time ＜ 5s or ＞ 30s to throw aside, to prevent foot from scalding, should also set deadline, generally 60s), with small
The incubation period that mouse adds metapedes reaction is pain indicator, takes 40 female mices, is divided into 4 groups, 10/group, i.e. embodiment 1-3 with it is right
1 group of ratio.
Test method：Mouthwash 0.5ml, 10min are smeared in the boiling hot foot position of mouse once, 6 times a day, continuous 2 days, are surveyed
Determine to add the sufficient time after last medicine in 60min, in 120min, it is specific as shown in table 3.
The mouse of table 3 licks sufficient reaction time (unit：min)
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Negative control |
| In 60min | 6.3 | 7.9 | 8.2 | 10.6 | 13.2 |
| In 120min | 13.0 | 14.2 | 14.6 | 19.5 | 26.3 |
From table 3 it is observed that after mouse smears mouthwash 1h and 2h, mouthwash made from 1-3 of the embodiment of the present invention
Mouse adds the sufficient time and is significantly less than comparative example 3 after smearing, illustrates that mouthwash of the present invention can reduce mouse and add the sufficient time, further
Illustrate that the folium artemisiae argyi flavones contained in present component is used with good analgesic activity with the active component compatibility in danshensu.
Test example 4, effect test
4.1 prevent and treat halitosis experiment
Subjects：The mouthwash of the flavones containing folium artemisiae argyi made from embodiment 1-3.
Experiment：Each 18 people of men and women, with halitosis caused by oral inflammation.
Test method：It is randomly divided into 3 groups, every group of 12 people, every group uses a kind of mouthwash, and 1h is used after meal, every time containing gargling
30s, is tested after one month, and concrete outcome is shown in Table 4.
Index：Using 6 grades of intensity representations, (0 grade：Odorless；1 grade：It is micro- to there is foul smell to feel (instrument detection)；2 grades：Slightly
The sensation (detected by scent) of stink；3 grades：Stink is obvious；4 grades：Foul smell is stronger；5 grades：Fetor), the change that removes a bad smell is maximum
With two minimum people, the average value of remaining 10 people is taken.
The anti-halitosis result of table 4
| Grade | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Before use | 3.5 | 3.4 | 3.7 |
| After use | 0.9 | 1.3 | 1.4 |
As can be known from Table 4, mouthwash made from embodiment 1-3 disclosed by the invention can effectively solve problem of bad breath.
4.2 swelling and aching of gum, oral mucosa are damaged
Subjects：Each 60 people of 15-35 Sui men and women, is randomly divided into 3 groups, every group of 40 people, and every group uses a kind of mouthwash, meal
1h is used afterwards, every time containing 45s is gargled, is tested after 3 months, concrete outcome is shown in Table 5.
Wherein, 20 patients are swelling and aching of gum (course of disease be 3 months, harmless nerve), 20 patients be mucous membrane of mouth by
Damage (course of disease is 3 months, harmless nerve)；
Therapeutic effect is：Cure, it is effective, invalid.Obtained therapeutic effect is as shown in table 5.
The prevention effect of mouthwash prepared by the embodiment 1-3 of table 5 to mouth disease
As can be seen from Table 5 the mouthwash that provides of the present invention continuously using 3 months to swelling and aching of gum and mucous membrane of mouth by
Damaging has good prevention effect, in addition, the production technique is simple, low in raw material price, and and generally, it is easy to purchase, and
And effect significantly, had in market in the future certain economy, practicality, society it is perspective.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (8)
1. the mouthwash of a kind of flavones containing folium artemisiae argyi, it is characterised in that be mainly made up of following component and its parts by weight：Folium artemisiae argyi flavones
2-4 parts, 0.1-0.3 parts of danshensu, 0.1-0.3 parts of plant enzyme, 0.5-1 parts of antiseptic, 1-2 parts of APG, carboxymethyl it is fine
Plain 0.05-0.1 parts of the sodium of dimension, 0.4-0.6 parts of dipotassium glycyrrhizinate, 0.3-0.5 parts of vitamin C, 0.2-0.4 parts of sodium chloride and water 90-
95 parts.
2. the mouthwash of the flavones as claimed in claim 1 containing folium artemisiae argyi, it is characterised in that by following component and its parts by weight group
Into：3 parts of folium artemisiae argyi flavones, 0.2 part of danshensu, 0.2 part of plant enzyme, 0.8 part of antiseptic, 1.5 parts of APG, carboxymethyl cellulose
92 parts of plain 0.08 part of sodium, 0.5 part of dipotassium glycyrrhizinate, 0.4 part of vitamin C, 0.3 part of sodium chloride and water.
3. the mouthwash of the flavones as claimed in claim 1 or 2 containing folium artemisiae argyi, it is characterised in that described plant enzyme is by pawpaw
Protease, bromelain and kelp ferment are 1-3 by weight：1-3：1 composition.
4. the mouthwash of the flavones as claimed in claim 3 containing folium artemisiae argyi, it is characterised in that described plant enzyme is by Papain
Enzyme, bromelain and kelp ferment are 2 by weight：2：1 composition.
5. the mouthwash of the flavones as claimed in claim 1 or 2 containing folium artemisiae argyi, it is characterised in that described antiseptic is by lactic acid chain
Coccus element, epsilon-polylysine hydrochloride and glycine are by weight 2-4：1-3：1 composition.
6. the mouthwash of the flavones as claimed in claim 5 containing folium artemisiae argyi, it is characterised in that described antiseptic is by streptococcus lactis
Element, epsilon-polylysine hydrochloride and glycine are by weight 3：2：1 composition.
7. the preparation method of the mouthwash of the flavones containing folium artemisiae argyi as described in claim any one of 1-6, it is characterised in that step
For：APG, sodium carboxymethylcellulose, dipotassium glycyrrhizinate, danshensu, sodium chloride are put into water and is completely dissolved, is warming up to
50-60 DEG C, 15-20min is stirred, mixing speed is 100-150r/min, be then cooled to 35-45 DEG C, add vitamin C, Chinese mugwort
Leaf flavones, plant enzyme and antiseptic, stir, and are down to room temperature, produce.
8. the mouthwash of the flavones containing folium artemisiae argyi as described in claim any one of 1-7 is preparing the impaired medicine of auxiliary treatment oral mucosa
Application in thing.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108042422A (en) * | 2017-12-25 | 2018-05-18 | 南昌航空大学 | A kind of antibacterial mouthwash of composite Chinese herbal and preparation method thereof |
| CN114557932A (en) * | 2022-03-03 | 2022-05-31 | 李时珍医药集团有限公司 | Toothpaste containing folium artemisiae argyi and rosemary leaf extracts and preparation method thereof |
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| CN102293725A (en) * | 2011-08-19 | 2011-12-28 | 哈尔滨医科大学 | Manufacture process for gargle used for oral cavity cleanness |
| CN102579313A (en) * | 2012-03-28 | 2012-07-18 | 罗妃 | External liquid preparation capable of preventing secondary chromatosis from happening after skin trauma operations |
| CN105326656A (en) * | 2015-10-29 | 2016-02-17 | 山东省药学科学院 | Oral antibacterial composition containing nisin and polylysine and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293725A (en) * | 2011-08-19 | 2011-12-28 | 哈尔滨医科大学 | Manufacture process for gargle used for oral cavity cleanness |
| CN102579313A (en) * | 2012-03-28 | 2012-07-18 | 罗妃 | External liquid preparation capable of preventing secondary chromatosis from happening after skin trauma operations |
| CN105326656A (en) * | 2015-10-29 | 2016-02-17 | 山东省药学科学院 | Oral antibacterial composition containing nisin and polylysine and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042422A (en) * | 2017-12-25 | 2018-05-18 | 南昌航空大学 | A kind of antibacterial mouthwash of composite Chinese herbal and preparation method thereof |
| CN114557932A (en) * | 2022-03-03 | 2022-05-31 | 李时珍医药集团有限公司 | Toothpaste containing folium artemisiae argyi and rosemary leaf extracts and preparation method thereof |
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| CN107242983B (en) | 2020-04-10 |
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