CN108042422A - A kind of antibacterial mouthwash of composite Chinese herbal and preparation method thereof - Google Patents
A kind of antibacterial mouthwash of composite Chinese herbal and preparation method thereof Download PDFInfo
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- CN108042422A CN108042422A CN201711420342.9A CN201711420342A CN108042422A CN 108042422 A CN108042422 A CN 108042422A CN 201711420342 A CN201711420342 A CN 201711420342A CN 108042422 A CN108042422 A CN 108042422A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses antibacterial mouthwashes of a kind of composite Chinese herbal and preparation method thereof, belong to rinse product field, and in particular to a kind of antibacterial mouthwash of composite Chinese herbal and preparation method thereof.The antibacterial mouthrinse components mass percentage of composite Chinese herbal in the present invention is:0.1 ~ 0.5 part of wormwood extract;0.1 ~ 0.5 part of Chloranthus glaber;99.7% 5 ~ 15 parts of absolute ethyl alcohol;5 ~ 10 parts of glycerine;1.2 parts of K12+DGL;0.04 part of EDTA disodiums;0.01 ~ 0.05 part of ascorbic acid;Essence(Peppermint)0.01 ~ 0.05 part;Deionized water adds to 100 parts.Using wormwood to inhibition and the lethal effect of a variety of viruses and bacterium in the present invention, Chloranthus glaber achievees the purpose that the quick bacterium removed in oral cavity with clearing heat and detoxicating, swelling and pain relieving, antibacterial anti-inflammatory and other effects, cleans to the region that toothbrush can not clean, it is safe and free of toxic and side effects with antibacterial and deodorization functions.The gargle of the present invention is kept a public place clean with oral cavity, inhibits the function of harmful microorganism and deodorization.Gargle formulation optimization, easily prepares, and cost is relatively low.
Description
Technical field
The invention belongs to daily necessities fields, are related to a kind of mouthwash and preparation method thereof, have more particularly to one kind and kill
Bacterium cleans antibacterial mouthwash of composite Chinese herbal of two-in-one effect and preparation method thereof.
Background technology
Oral health is closely bound up with health, and mouth disease is mostly all related with bacterium, such as saprodontia and canker sore.
Saprodontia is bacteriosis, and due to oral cavity ecological disturbance, normal bacteria becomes conditioned pathogen and causes.It can be with secondary dental pulp
Scorching and periapical inflammation or even alveolar bone and inflammation of jaws etc. can be caused, cause the whole destructions for suffering from tooth;The scabies secondary infection of saprodontia can
To form lesion, bacteriotoxin borrows blood circulation to be expanded to whole body, induces systemic disease.Canker sore is a kind of more typical
Transmucosal disease, be mostly that bacterium or virus infection cause, incidence is high and easily recurs, and when morbidity has severe pain to feel,
Influence feed and speak, brought to patient huge painful and inconvenient, particularly meet acid, into, peppery food when the pain increased.
Routine, which is brushed teeth, is merely able to the bacterial plaque for removing facing part, substantially incompetent for the bacterial plaque of removing oral soft tissue surfaces
For power.And mouthwash can deep each position of human mouth, be a kind of auxiliary well between gingival edge and teeth space including the difficult contact of toothbrush
Help control bacterial plaque measure.Mouthwash is easy to carry using simple, is the old man of loss of tooth, the child that will not be brushed teeth and not
The optimal selection for the dental patient's oral hygiene guarantee brushed teeth can be endured.Meanwhile mouthwash also has very big social effect, it
It can make people's oral cavity fresh and cool after use, increase confidence, show glamour.
Antibacterial mouthwash currently on the market adds in the ingredients such as metronidazole or hydrogen peroxide mostly, but is gargled using metronidazole
Water changes there are the sense of taste can generate facing decalcification with adverse reactions, hydrogen peroxide long-time services such as oral mucosa shouting pain, Nausea and vomitings
With the side effects such as black hairy tongue.
Wormwood is the conventional foodstuff in China, and green grass or young crops group, Chinese mugwort Ci are made by raw material of wormwood, and A sweety scent assails the nostrils for smell, is day
So green and healthy traditional characteristics snack, it is from ancient times deep to be doted on by people.The pharmacological research of modern medicine shows that wormwood is a kind of
The drug of broad-spectrum antibacterial antiviral, it has significant inhibition and lethal effect to a variety of viruses and bacterium.Chloranthus glaber has clear
Thermal detoxification, swelling and pain relieving, antibacterial anti-inflammatory and other effects have been used for resisting bleeding gums in toothpaste, repair canker sore, improve tooth
Gum swells and ache, the effect of Eradicates removing abnormal flavor in oral cavity, while plays an important role of the problems such as preventing gingivitis, periodontitis, gingival atrophy..Oral cavity
In bacterium environment it is complicated, select wormwood and the compound wide-spectrum bactericide as among mouthwash of Herba Pileae Scriptae extract, Ke Yiyou
The harmful bacteria in oral cavity is killed on effect ground, prevents bleeding gums, periodontitis, gingival atrophy etc..
N- lauryl glucoside base lauramides(DGL)It is the starch based surfactants prepared using starch as raw material,
Have the characteristics that nontoxic, pollution-free, biological degradability is good, performance is mild, irritation is low.Lauryl sodium sulfate(K12)Belong to cloudy
Ionic surface active agent, it is soluble easily in water, it is good to answer compatibility with anion, nonionic, has and good emulsify, foams, permeate, go
Dirty and dispersion performance.Two kinds of surfactant compounds, which are added in mouthwash, can improve its cleaning effect to oral cavity.
The content of the invention
To solve the above-mentioned problems, the present invention provides a kind of antibacterial mouthwash of composite Chinese herbal and preparation method thereof, this hair
Bright mouthwash preparation method is simple, has cleaning, antibiotic and sterilizing, fresh breath, prevention mouth disease and other effects.
Technical solution provided by the invention is:A kind of antibacterial mouthwash of composite Chinese herbal is included in parts by weight as following
Ingredient:
Wormwood extract, 0.05 ~ 0.25 part;
Chloranthus glaber, 0.05 ~ 0.25 part;
Absolute ethyl alcohol, 15 parts;
Glycerine, 5 ~ 10 parts;
K12+DGL, 1 ~ 1.4 part;
EDTA- disodiums, 0.02 ~ 0.04 part;
Ascorbic acid, 0.01 ~ 0.05 part;
Essence(Peppermint), 0.01 ~ 0.05 part;
Deionized water adds to 100 parts.
Further, the antibacterial mouthwash of a kind of composite Chinese herbal, in parts by weight including following ingredients:
Wormwood extract, 0.1 ~ 0.2 part;
Chloranthus glaber, 0.1 ~ 0.2 part;
Absolute ethyl alcohol, 15 parts;
Glycerine, 6 ~ 9 parts;
K12+DGL, 1.1 ~ 1.3 parts;
EDTA- disodiums, 0.02 ~ 0.04 part;
Ascorbic acid, 0.02 ~ 0.04 part;
Essence(Peppermint), 0.02 ~ 0.04 part;
Deionized water adds to 100 parts.
Further, the antibacterial mouthwash of a kind of composite Chinese herbal, in parts by weight including following ingredients:
Wormwood extract, 0.15 part;
Chloranthus glaber, 0.1 5 parts;
Absolute ethyl alcohol, 15 parts;
Glycerine, 8 parts;
K12+DGL, 1.2 parts;
EDTA- disodiums, 0.03 part;
Ascorbic acid, 0.03 part;
Essence(Peppermint), 0.03 part;
Deionized water adds to 100 parts.
A kind of preparation method of the antibacterial mouthwash of composite Chinese herbal, the preparation method of the Chinese medicine mouth wash is including following
Step:
(1)Wormwood drying shreds, and carries out ultrasonic wave extraction by the use of ethyl alcohol as solvent, carries out suction filtration operation after extraction, obtain wormwood
Ethanol extract steams a large amount of ethyl alcohol using Rotary Evaporators, obtains wormwood extract(Medicinal extract);
(2)Take 0.05 ~ 0.25 part of wormwood extract respectively by weight;0.05 ~ 0.25 part of Chloranthus glaber;15 parts of absolute ethyl alcohol;Glycerine 5
~ 10 parts;1.2 parts of K12+DGL;0.04 part of EDTA- disodiums;0.01 ~ 0.05 part of ascorbic acid;Essence(Peppermint) 0.01~
0.05 part;Deionized water adds to 100 parts.It is stirred until homogeneous, obtains the antibacterial mouthwash of composite Chinese herbal.
A kind of preparation method of the antibacterial mouthwash of composite Chinese herbal, step(1)It is middle to shred wormwood drying, use second
Feed liquid solid-to-liquid ratio is 1g when alcohol is as solvent progress ultrasonic wave extraction:12mL, the ultrasonic extraction time be 3h, rotating evaporation temperature
It it is 45 DEG C, evaporation time is 3h.
A kind of preparation method of the antibacterial mouthwash of composite Chinese herbal, speed of agitator is 100r-200r in step,
Middle wormwood extract, Herba Pileae Scriptae extract and Mint Essence are dissolved in absolute ethyl alcohol, and other compositions are dissolved in deionized water.
Beneficial effects of the present invention:The antibacterial mouthwash of composite Chinese herbal of the present invention adds wormwood extract and Chloranthus glaber carries
Object is taken to have apparent inhibition killing effect to oral bacteria.
Specific embodiment
Embodiment 1
A kind of antibacterial mouthwash of composite Chinese herbal, is prepared by the following each component of weight in the present embodiment:Wormwood extract
0. 05g;Chloranthus glaber 0.05g;Absolute ethyl alcohol 15g;Glycerine 5g;K12+DGL 1g;EDTA- disodiums 0.02g;Ascorbic acid
0.01g;Essence(Peppermint) 0.01g;Deionized water adds to 100g.
A kind of preparation method of the antibacterial mouthwash of composite Chinese herbal, rapid including following steps described in the present embodiment:
(1)Wormwood drying, which shreds, weighs, by 1g:The solid-to-liquid ratio of 12ml adds in absolute ethyl alcohol, after ultrasonic extraction 3h, carries out suction filtration behaviour
Obtain wormwood ethanol extract.A large amount of ethyl alcohol are steamed at 45 DEG C using Rotary Evaporators, obtain wormwood extract(Medicinal extract);
(2)Wormwood extract, Herba Pileae Scriptae extract and Mint Essence are dissolved in absolute ethyl alcohol by formula, other compositions are dissolved in
It goes.In ionized water, it is the antibacterial mouthwash of composite Chinese herbal to be mixing uniformly to form clear solution.
Embodiment 2
A kind of antibacterial mouthwash of composite Chinese herbal, is prepared by the following each component of weight in the present embodiment:Wormwood extract
0.15g;Chloranthus glaber 0.15g;Absolute ethyl alcohol 15g;Glycerine 10g;K12+DGL 1.1g;EDTA- disodiums 0.03g;Ascorbic acid
0.03g;Essence(Peppermint) 0.03g;Deionized water adds to 100g.
A kind of preparation method of the antibacterial mouthwash of composite Chinese herbal, rapid including following steps described in the present embodiment:
(1)Wormwood drying, which shreds, weighs, by 1g:The solid-to-liquid ratio of 12ml adds in absolute ethyl alcohol, after ultrasonic extraction 3h, carries out suction filtration behaviour
Obtain wormwood ethanol extract.A large amount of ethyl alcohol are steamed at 45 DEG C using Rotary Evaporators, obtain wormwood extract(Medicinal extract);
(2)Wormwood extract, Herba Pileae Scriptae extract and Mint Essence are dissolved in absolute ethyl alcohol by formula, other compositions are dissolved in
In ionized water, it is the antibacterial mouthwash of composite Chinese herbal to be mixing uniformly to form clear solution.
Embodiment 3
A kind of antibacterial mouthwash of composite Chinese herbal, is prepared by the following each component of weight in the present embodiment:Wormwood extract
0. 15;Chloranthus glaber 0.15g;Absolute ethyl alcohol 15g;Glycerine 10g;K12+DGL 1.1g;EDTA- disodiums 0.03g;Ascorbic acid
0.03g;Essence(Peppermint) 0.03g;Deionized water adds to 100g.
A kind of preparation method of the antibacterial mouthwash of composite Chinese herbal, rapid including following steps described in the present embodiment:
(1)Wormwood drying, which shreds, weighs, by 1g:The solid-to-liquid ratio of 12ml adds in absolute ethyl alcohol, after ultrasonic extraction 3h, carries out suction filtration behaviour
Obtain wormwood ethanol extract.A large amount of ethyl alcohol are steamed at 45 DEG C using Rotary Evaporators, obtain wormwood extract(Medicinal extract);
(2)Wormwood extract, Herba Pileae Scriptae extract and Mint Essence are dissolved in absolute ethyl alcohol by formula, other compositions are dissolved in
In ionized water, it is the antibacterial mouthwash of composite Chinese herbal to be mixing uniformly to form clear solution.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed
With it can be applied to various suitable the field of the invention completely, can be easily real for those skilled in the art
Now other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is not limited to
Specific details and shown here as the embodiment with description.
Claims (6)
1. a kind of antibacterial mouthwash of composite Chinese herbal, it is characterised in that include such as following compositions in parts by weight:
Wormwood extract, 0.05 ~ 0.25 part;
Chloranthus glaber, 0.05 ~ 0.25 part;
Absolute ethyl alcohol, 15 parts;
Glycerine, 5 ~ 10 parts;
K12+DGL, 1 ~ 1.4 part;
EDTA- disodiums, 0.02 ~ 0.04 part;
Ascorbic acid, 0.01 ~ 0.05 part;
Essence(Peppermint), 0.01 ~ 0.05 part;
Deionized water adds to 100 parts.
2. a kind of antibacterial mouthwash of composite Chinese herbal according to claim 1, it is characterised in that:Under including in parts by weight
The ingredient stated:
Wormwood extract, 0.1 ~ 0.2 part;
Chloranthus glaber, 0.1 ~ 0.2 part;
Absolute ethyl alcohol, 15 parts;
Glycerine, 6 ~ 9 parts;
K12+DGL, 1.1 ~ 1.3 parts;
EDTA- disodiums, 0.02 ~ 0.04 part;
Ascorbic acid, 0.02 ~ 0.04 part;
Essence(Peppermint), 0.02 ~ 0.04 part;
Deionized water adds to 100 parts.
3. a kind of antibacterial mouthwash of composite Chinese herbal according to claim 2, it is characterised in that:During described one kind is compound
The antibacterial mouthwash of herbal medicine, in parts by weight including following ingredients:
Wormwood extract, 0.15 part;
Chloranthus glaber, 0.1 5 parts;
Absolute ethyl alcohol, 15 parts;
Glycerine, 8 parts;
K12+DGL, 1.2 parts;
EDTA- disodiums, 0.03 part;
Ascorbic acid, 0.03 part;
Essence(Peppermint), 0.03 part;
Deionized water adds to 100 parts.
4. a kind of preparation method of the antibacterial mouthwash of composite Chinese herbal according to claim 1, it is characterised in that:Described
The preparation method of Chinese medicine mouth wash comprises the following steps:
(1)Wormwood drying shreds, and carries out ultrasonic wave extraction by the use of ethyl alcohol as solvent, carries out suction filtration operation after extraction, obtain wormwood
Ethanol extract steams a large amount of ethyl alcohol using Rotary Evaporators, obtains wormwood extract;
(2)Take 0.05 ~ 0.25 part of wormwood extract respectively by weight;0.05 ~ 0.25 part of Chloranthus glaber;15 parts of absolute ethyl alcohol;Glycerine 5
~ 10 parts;1.2 parts of K12+DGL;0.04 part of EDTA- disodiums;0.01 ~ 0.05 part of ascorbic acid;Essence(Peppermint) 0.01~
0.05 part;Deionized water adds to 100 parts;It is stirred until homogeneous, obtains the antibacterial mouthwash of composite Chinese herbal.
5. a kind of preparation method of the antibacterial mouthwash of composite Chinese herbal according to claim 4, it is characterised in that:Step
(1)It is middle by wormwood drying shred, by the use of ethyl alcohol as solvent progress ultrasonic wave extraction when feed liquid solid-to-liquid ratio be 1g:12mL, ultrasound
Extraction time is 3h, and rotating evaporation temperature is 45 DEG C, and evaporation time is 3h.
6. a kind of preparation method of the antibacterial mouthwash of composite Chinese herbal according to claim 4, it is characterised in that:Described
A kind of preparation method of the antibacterial mouthwash of composite Chinese herbal, speed of agitator is 100r-200r in step, wherein wormwood extract,
Herba Pileae Scriptae extract is dissolved in Mint Essence in absolute ethyl alcohol, and other compositions are dissolved in deionized water.
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CN201711420342.9A CN108042422A (en) | 2017-12-25 | 2017-12-25 | A kind of antibacterial mouthwash of composite Chinese herbal and preparation method thereof |
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CN201711420342.9A CN108042422A (en) | 2017-12-25 | 2017-12-25 | A kind of antibacterial mouthwash of composite Chinese herbal and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111690480A (en) * | 2020-06-23 | 2020-09-22 | 刘晓彤 | Anti-inflammation and sterilization traditional Chinese medicine toothbrush cleaning sheet |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1076356A (en) * | 1993-02-12 | 1993-09-22 | 江西黎明制药厂 | A kind of health care collutory and method for making thereof |
CN1119541A (en) * | 1995-04-25 | 1996-04-03 | 卢建中 | Gargle made of sarcandra glabra |
CN107242983A (en) * | 2017-06-15 | 2017-10-13 | 广州暨南生物医药研究开发基地有限公司 | A kind of mouthwash of the flavones containing folium artemisiae argyi and preparation method thereof |
-
2017
- 2017-12-25 CN CN201711420342.9A patent/CN108042422A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1076356A (en) * | 1993-02-12 | 1993-09-22 | 江西黎明制药厂 | A kind of health care collutory and method for making thereof |
CN1119541A (en) * | 1995-04-25 | 1996-04-03 | 卢建中 | Gargle made of sarcandra glabra |
CN107242983A (en) * | 2017-06-15 | 2017-10-13 | 广州暨南生物医药研究开发基地有限公司 | A kind of mouthwash of the flavones containing folium artemisiae argyi and preparation method thereof |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111690480A (en) * | 2020-06-23 | 2020-09-22 | 刘晓彤 | Anti-inflammation and sterilization traditional Chinese medicine toothbrush cleaning sheet |
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Application publication date: 20180518 |