CN107242983B - Mouth wash containing folium artemisiae argyi flavone and preparation method thereof - Google Patents
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention belongs to the field of daily chemical nursing products, and particularly relates to a mouthwash containing folium artemisiae argyi flavone and a preparation method thereof, wherein the mouthwash mainly comprises the following components in parts by weight: 2-4 parts of folium artemisiae argyi flavone, 0.1-0.3 part of danshensu, 0.1-0.3 part of plant enzyme, 0.5-1 part of antibacterial agent, 1-2 parts of alkyl glycoside, 0.05-0.1 part of sodium carboxymethylcellulose, 0.4-0.6 part of dipotassium glycyrrhizinate, 0.3-0.5 part of vitamin C, 0.2-0.4 part of sodium chloride and 90-95 parts of water.
Description
Technical Field
The invention belongs to the field of daily chemical nursing products, and particularly relates to a mouthwash containing folium artemisiae argyi flavone and a preparation method thereof.
Background
As social etiquette is more and more important in people's life, people pay attention to smell in the mouth as an important part of self-image besides making up and speaking, and bad breath easily causes unpleasant talk in daily communication, wherein the causes of bad breath include 1, oral diseases; 2. intestinal diseases; 3. dietary problems, however, the most common cause of oral malodour is oral bacteria, and oral bacteria can cause oral disease and further oral malodour, forming a vicious circle.
The common means for solving the peculiar smell of the oral cavity is tooth brushing, tooth washing or regular tooth health care, but in the external work, the oral cavity cleaning is not suitable, so that the gargle is a common means for solving the embarrassment situation and does not hurt the gum, but because the gargle can not carry out physical friction to clean dirt on the surface of the tooth, hydrogen peroxide or antibacterial components such as chlorhexidine are added into a lot of modern gargles, but the hydrogen peroxide easily damages the tooth, the chlorhexidine can increase the blood pressure, and further the probability of heart disease and stroke is increased. Therefore, the addition of natural safe ingredients is the development trend of the existing mouthwash.
The Chinese patent application with the publication number of CN106491452A discloses an oral care agent and a preparation method thereof, and the oral care agent comprises the following formula components in parts by mass: 10-20 parts of thymol, 14-16 parts of cinnamon oil, 6-8 parts of curcumin, 7-9 parts of menthol, 3-5 parts of tea polyphenol, 6-8 parts of eucalyptus oil, 5-7 parts of blumea oil, 3-7 parts of clove oil, 5-7 parts of creatine, 5-7 parts of broadleaf holly leaf, 6-10 parts of wintergreen oil and 2-3 parts of salt. However, the invention mainly uses essential oil components, has nephrotoxicity and is not recommended for oral application.
Chinese patent application publication No. CN105616324A discloses a mouthwash containing a plant formulation and a preparation method thereof, the mouthwash comprising 0.33-40 parts by mass of an active ingredient, 1-15 parts by mass of a flavoring agent, and 40-95 parts by mass of water, wherein the active ingredient comprises 0.1-8 parts by mass of propolis, 0.01-5 parts by mass of casein phosphopeptide, 0.1-0.5 parts by mass of broadleaf holly leaf extract, 0.01-5 parts by mass of zanthoxylum bungeanum extract, 0.01-0.3 parts by mass of garlic extract, 0.05-5 parts by mass of tea polyphenol, and 0.05-5 parts by mass of clove extract.
Disclosure of Invention
In order to solve the defects in the prior art, the invention provides the mouthwash containing the folium artemisiae argyi flavone and the preparation method thereof.
The technical scheme of the invention is as follows:
a mouth wash containing folium artemisiae argyi flavone mainly comprises the following components in parts by weight: 2-4 parts of folium artemisiae argyi flavone, 0.1-0.3 part of danshensu, 0.1-0.3 part of plant enzyme, 0.5-1 part of antibacterial agent, 1-2 parts of alkyl glycoside, 0.05-0.1 part of sodium carboxymethyl cellulose, 0.4-0.6 part of dipotassium glycyrrhizinate, 0.3-0.5 part of vitamin C, 0.2-0.4 part of sodium chloride and 90-95 parts of water.
Preferably, the folium artemisiae argyi flavone-containing mouthwash is composed of the following components in parts by weight: 3 parts of folium artemisiae argyi flavone, 0.2 part of danshensu, 0.2 part of plant enzyme, 0.8 part of antibacterial agent, 1.5 parts of alkyl glycoside, 0.08 part of sodium carboxymethyl cellulose, 0.5 part of dipotassium glycyrrhizinate, 0.4 part of vitamin C, 0.3 part of sodium chloride and 92 parts of water.
The alkyl glycoside (CAS:141464-42-8) is a cleaning component of the mouthwash, has small irritation and is easy to biodegrade.
Folium artemisiae argyi flavone: the flavonoids extracted from folium Artemisiae Argyi have effects of scavenging free radicals, protecting intestinal canal, resisting allergy, inhibiting bacteria and virus, and the folium Artemisiae Argyi flavonoids applied in toothpaste has good antibacterial and antiinflammatory effects.
The extraction method of the folium artemisiae argyi flavone comprises the following steps: taking fresh folium artemisiae argyi, drying, crushing, adding 95% ethanol by volume fraction, performing ultrasonic extraction for 3h, taking filtrate, concentrating under reduced pressure, and performing freeze drying to obtain the folium artemisiae argyi-ethanol extract.
Danshensu: the salvianic acid is a water-soluble substance component contained in the salvia miltiorrhiza, has the effects of inhibiting platelet aggregation, resisting coagulation, expanding coronary artery, improving cardiac function, resisting atherosclerosis, resisting oxidative damage, reducing blood fat and the like, is applied to mouthwash, finds that the salvianic acid is beneficial to enhancing the anti-inflammatory effect of folium artemisiae argyi flavone in toothpaste, is beneficial to strengthening the pain feeling of gum swelling and pain, and has good analgesic effect.
Further, the plant ferment is prepared from papain, bromelain and laminarin in a weight ratio of 1-3: 1-3: 1.
Preferably, the plant ferment is prepared from papain, bromelain and laminarin in a weight ratio of 2: 2: 1.
The papain and the bromelain are beneficial to decomposition of protein substances in the oral cavity, fresh breath and stimulation of oral mucosa are avoided, and the laminaria enzyme in the plant enzyme is beneficial to regeneration of oral cells and has a good repairing effect on damage of the oral mucosa.
Further, the antibacterial agent is prepared from nisin, epsilon-polylysine hydrochloride and glycine according to a weight ratio of 2-4: 1-3: 1.
Preferably, the antibacterial agent is prepared from nisin, epsilon-polylysine hydrochloride and glycine in a weight ratio of 3: 2: 1. Wherein the nisin is a high-efficiency, nontoxic, safe and side-effect-free bactericide; the epsilon-polylysine hydrochloride (CAS:28211-04-3) is a novel bactericide, and the bactericidal effect of the toothpaste can be improved by using the glycine, the nisin and the epsilon-polylysine hydrochloride together.
The invention also provides a preparation method of the folium artemisiae argyi flavone-containing mouthwash, which comprises the following steps: dissolving alkyl glycoside, sodium carboxymethylcellulose, dipotassium glycyrrhizinate, tanshinol and sodium chloride in water completely, heating to 50-60 ℃, stirring for 15-20min at the stirring speed of 100-.
The invention also discloses application of the folium artemisiae argyi flavone-containing mouthwash in preparation of a medicine for assisting in treating oral mucosa damage.
The components of the invention are safe, the compatibility is reasonable and scientific, and the compatibility of the folium artemisiae argyi flavone and the danshensu with the plant enzyme is favorable for diminishing inflammation and easing pain of oral diseases, and can effectively solve the oral problems of halitosis, gum swelling and pain, oral mucosa and the like.
Compared with the prior art, the invention has the following advantages: (1) the components of the invention are all safe components, and the swallowing can not cause burden to the internal organs; (2) and (3) antibacterial type: the mouth wash containing folium artemisiae argyi flavone has good bactericidal performance on oral bacteria, and can prevent and treat decayed teeth; (3) anti-inflammatory: the invention can effectively prevent and treat oral inflammation.
Detailed Description
The present invention is further illustrated by the following examples, which will enable those skilled in the art to better understand the technical solutions of the present invention. The ingredients of the invention all belong to conventional products, wherein papain (specification of 20:1), bromelain (specification of 20:1) and laminaria enzyme (product: laminaria enzyme powder) are purchased from Simansuote biotechnology limited.
Example 1A mouthwash containing flavonoids of Artemisia argyi
The mouthwash containing the folium artemisiae argyi flavone is composed of the following components in parts by weight: 3 parts of folium artemisiae argyi flavone, 0.2 part of salvianic acid A, 0.2 part of plant enzyme, 0.8 part of antibacterial agent, 1.5 parts of alkyl glycoside, 0.08 part of sodium carboxymethyl cellulose, 0.5 part of dipotassium glycyrrhizinate, 0.4 part of vitamin C, 0.3 part of sodium chloride and 92 parts of water;
the plant ferment is prepared from papain, bromelain and kelp ferment in a weight ratio of (2): 2: 1, preparing a composition;
the antibacterial agent is prepared from nisin, epsilon-polylysine hydrochloride and glycine according to a weight ratio of 3: 2: 1, preparing a composition;
the extraction method of the folium artemisiae argyi flavone comprises the following steps: taking fresh folium artemisiae argyi, drying, crushing, adding 95% ethanol by volume fraction, performing ultrasonic extraction for 3h, taking filtrate, concentrating under reduced pressure, and performing freeze drying to obtain the folium artemisiae argyi-ethanol extract.
The preparation method of the folium artemisiae argyi flavone-containing mouthwash comprises the following steps: dissolving alkyl glycoside, sodium carboxymethylcellulose, dipotassium glycyrrhizinate, tanshinol and sodium chloride in water completely, heating to 55 deg.C, stirring for 18min at a stirring speed of 130r/min, cooling to 40 deg.C, adding vitamin C, folium Artemisiae Argyi flavone, plant ferment and antibacterial agent, stirring well, and cooling to room temperature to obtain the final product.
Example 2A mouthwash containing folium Artemisiae Argyi flavones
The mouthwash containing the folium artemisiae argyi flavone is composed of the following components in parts by weight: 2 parts of folium artemisiae argyi flavone, 0.3 part of salvianic acid A, 0.3 part of plant enzyme, 0.5 part of antibacterial agent, 1 part of alkyl glycoside, 0.05 part of sodium carboxymethyl cellulose, 0.6 part of dipotassium glycyrrhizinate, 0.5 part of vitamin C, 0.4 part of sodium chloride and 90 parts of water;
the plant ferment is prepared from papain, bromelain and kelp ferment in a weight ratio of 1: 3: 1, preparing a composition;
the antibacterial agent is prepared from nisin, epsilon-polylysine hydrochloride and glycine according to a weight ratio of 2: 3: 1, preparing a composition;
the extraction method of folium Artemisiae Argyi flavone is similar to example 1.
The preparation method of the mouthwash containing the folium artemisiae argyi flavone is similar to that of example 1.
Example 3A mouthwash containing folium Artemisiae Argyi flavones
The mouthwash containing the folium artemisiae argyi flavone is composed of the following components in parts by weight: 4 parts of folium artemisiae argyi flavone, 0.1 part of salvianic acid A, 0.1 part of plant enzyme, 1 part of antibacterial agent, 2 parts of alkyl glycoside, 0.1 part of sodium carboxymethyl cellulose, 0.4 part of dipotassium glycyrrhizinate, 0.3 part of vitamin C, 0.2 part of sodium chloride and 95 parts of water;
the plant ferment is prepared from papain, bromelain and kelp ferment in a weight ratio of (3): 1: 1, preparing a composition;
the antibacterial agent is prepared from nisin, epsilon-polylysine hydrochloride and glycine according to a weight ratio of 4: 1: 1, preparing a composition;
the extraction method of folium Artemisiae Argyi flavone is similar to example 1.
The preparation method of the mouthwash containing the folium artemisiae argyi flavone is similar to that of example 1.
Comparative example 1A mouthwash containing folium Artemisiae Argyi flavones
The mouthwash containing the folium artemisiae argyi flavone is composed of the following components in parts by weight: 3.2 parts of folium artemisiae argyi flavone, 0.2 part of plant enzyme, 0.8 part of antibacterial agent, 1.5 parts of alkyl glycoside, 0.08 part of sodium carboxymethyl cellulose, 0.5 part of dipotassium glycyrrhizinate, 0.4 part of vitamin C, 0.3 part of sodium chloride and 92 parts of water;
the plant ferment is prepared from papain, bromelain and kelp ferment in a weight ratio of (2): 2: 1, preparing a composition;
the antibacterial agent is prepared from nisin, epsilon-polylysine hydrochloride and glycine according to a weight ratio of 3: 2: 1, preparing a composition;
the extraction method of folium Artemisiae Argyi flavone is similar to example 1.
The preparation method of the mouthwash containing the folium artemisiae argyi flavone is similar to that of example 1.
The difference from the embodiment 1 is that the content of folium artemisiae argyi flavone is increased without adding danshensu.
Comparative example 2A mouthwash containing Ailanthus altissima flavone
The mouthwash containing the folium artemisiae argyi flavone is composed of the following components in parts by weight: 3 parts of folium artemisiae argyi flavone, 0.2 part of salvianic acid A, 0.2 part of plant enzyme, 0.8 part of antibacterial agent, 1.5 parts of alkyl glycoside, 0.08 part of sodium carboxymethyl cellulose, 0.5 part of dipotassium glycyrrhizinate, 0.4 part of vitamin C, 0.3 part of sodium chloride and 92 parts of water;
the plant ferment is prepared from papain and bromelain in a weight ratio of 2: 2, preparing a composition;
the antibacterial agent is prepared from nisin, epsilon-polylysine hydrochloride and glycine according to a weight ratio of 3: 2: 1, preparing a composition;
the extraction method of folium Artemisiae Argyi flavone is similar to example 1.
The preparation method of the mouthwash containing the folium artemisiae argyi flavone is similar to that of example 1.
The difference from example 1 is that no laminarin was added to the plant ferment.
Comparative example 3A mouthwash containing Ailanthus altissima flavone
The mouthwash containing the folium artemisiae argyi flavone is composed of the following components in parts by weight: 3 parts of folium artemisiae argyi flavone, 0.2 part of salvianic acid A, 0.2 part of plant enzyme, 0.8 part of antibacterial agent, 1.5 parts of alkyl glycoside, 0.08 part of sodium carboxymethyl cellulose, 0.5 part of dipotassium glycyrrhizinate, 0.4 part of vitamin C, 0.3 part of sodium chloride and 92 parts of water;
the plant ferment is prepared from papain, bromelain and kelp ferment in a weight ratio of (2): 2: 1, preparing a composition;
the antibacterial agent is prepared from nisin and epsilon-polylysine hydrochloride according to a weight ratio of 3: 2, preparing a composition;
the extraction method of folium Artemisiae Argyi flavone is similar to example 1.
The preparation method of the mouthwash containing the folium artemisiae argyi flavone is similar to that of example 1.
The difference from example 1 is that glycine is not added to the antibacterial agent.
Test example 1 anti-inflammatory test
Test subjects: the mouthwashes containing the flavonoids of mugwort prepared in examples 1 to 3 and comparative examples 1 to 3;
the test method comprises the following steps: 60 Kunming mice, each half of male and female, with the weight of 25-30 g, are randomly divided into 6 groups according to the weight, each group comprises 10 mice, the mice are anesthetized by ether, 20 mul of dimethylbenzene is uniformly coated on the right ear of the mice, after 30min, 0.5ml of mouthwash is coated on the inflammation part of the right ear of the mice, 10min is carried out once and 6 times continuously, the left ear is not treated, after 4 hours, the mice are killed, the two ears are cut off immediately, the ear sheets at the same part are taken by an 8mm puncher, weighing is carried out, and the swelling degree and the swelling rate are calculated; the swelling rate is right ear piece weight-left ear piece weight, and the swelling rate is swelling rate/left ear piece weight, and the results are shown in table 1 by averaging.
TABLE 1 Effect of mouthwash on swelling of mouse pinna by xylene
| Group of | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Swelling degree (mg) | 5.45 | 5.71 | 5.76 | 6.15 | 6.10 | 6.26 |
| Swelling Rate (%) | 70.25 | 72.66 | 72.95 | 76.82 | 76.62 | 77.01 |
As can be seen from Table 1, the anti-inflammatory effects of examples 1-3 of the present invention are significantly different from those of comparative examples 1-3, indicating that the mouth wash of the present invention has a good anti-inflammatory effect.
Test example 2 bacteriostatic test
Test subjects: the mouthwash containing the flavonoids in the mugwort prepared in examples 1-3 and comparative example 3 and the negative control were 0.9% by mass of normal saline;
test bacteria: candida albicans, Streptococcus sanguis, Streptococcus mutans, and Actinomyces viscosus;
the test method comprises the following steps: 0.2ml of mouthwash is dripped into a volume of 10ml of culture medium (surface area of 10 cm)23% solid agar obtained by mixing tryptose soy broth and agar), Candida albicans, Streptococcus sanguis, Streptococcus mutans and Actinomyces viscosus were inoculated, respectively, placed in a constant temperature incubator at 37 deg.C for 24 hours, and culturedCircular antibacterial rings were formed on the base surface, and the antibacterial ability was evaluated by measuring the diameters of the rings, as shown in Table 2.
TABLE 2 diameter of the antibacterial ring (unit: mm)
| Group of | Candida albicans | Streptococcus sanguis | Streptococcus mutans | Actinomyces viscosus |
| Example 1 | 10.26 | 21.03 | 30.42 | 26.35 |
| Example 2 | 9.63 | 19.56 | 28.93 | 24.45 |
| Example 3 | 9.25 | 18.99 | 27.95 | 23.87 |
| Comparative example 3 | 6.51 | 15.63 | 24.39 | 20.35 |
| Negative control | 0 | 0 | 0 | 0 |
As can be seen from Table 2, the negative control physiological saline does not produce any antibacterial ring, while the examples 1-3 and the comparative example 3 produce obvious antibacterial rings, wherein the mouthwash prepared by the examples 1-3 of the invention has better antibacterial effect than the comparative example 3, the antibacterial effect of the example 1 is the best, and the dental caries caused by Streptococcus mutans can be effectively prevented.
Test example 3 analgesic test
Test subjects: the gargle containing the folium artemisiae argyi flavone prepared in the example-3 and the comparative example 1 and the negative control are 0.9 mass percent of normal saline;
mouse hot plate pain model: female mice weighing about 22g are placed on a hot plate pain measuring instrument, 100 qualified mice are screened (the time for licking the feet is less than 5s or more than 30s and the mice are discarded, the cut-off time is set for preventing the feet from being scalded, the cut-off time is generally 60s), the latency period of the reaction of adding the feet to the mice is taken as the pain threshold index, and 40 female mice are divided into 4 groups and 10 groups, namely, the groups of examples 1-3 and the group of comparative example 1.
The test method comprises the following steps: applying collutory 0.5ml on the scalded foot part of mouse once for 10min, 6 times per day for 2 days, and measuring the time of foot addition within 60min and 120min after the last time, as shown in Table 3.
TABLE 3 mouse licking response time (unit: min)
| Group of | Example 1 | Example 2 | Example 3 | Comparative example 1 | Negative control |
| Within 60min | 6.3 | 7.9 | 8.2 | 10.6 | 13.2 |
| Within 120min | 13.0 | 14.2 | 14.6 | 19.5 | 26.3 |
As can be seen from Table 3, after the mouthwash is applied to the mice for 1 hour and 2 hours, the time for foot addition of the mice after the mouthwash prepared in examples 1-3 of the invention is applied is obviously shorter than that of comparative example 3, which shows that the time for foot addition of the mice can be reduced by the mouthwash of the invention, and further shows that the compatibility of the folium artemisiae argyi flavone contained in the components of the invention and the active components in the danshensu has good analgesic effect.
Test example 4, Effect test
4.1 test for prevention and treatment of halitosis
Test subjects: the mugwort leaf flavonoid-containing mouthwashes prepared in examples 1 to 3.
And (3) testing: 18 men and women, respectively, suffer from halitosis caused by oral inflammation.
The test method comprises the following steps: the test results are shown in table 4, wherein the test results are carried out after one month, and the test results are carried out after one month.
Indexes are as follows: by adopting a 6-level intensity representation method, (0 level: no odor, 1 level: slightly odor feeling (detected by an instrument), 2 level: slightly odor feeling (olfactory perception), 3 level: obvious odor, 4 level: strong odor, and 5 level: strong odor), two persons with the largest and the smallest odor change are removed, and the average value of the rest 10 persons is taken.
TABLE 4 results against halitosis
| Grade | Example 1 | Example 2 | Example 3 |
| Before use | 3.5 | 3.4 | 3.7 |
| After use | 0.9 | 1.3 | 1.4 |
As can be seen from Table 4, the mouthwashes prepared in examples 1-3 of the present disclosure are effective in resolving bad breath problems.
4.2 swelling and aching of gum, damage to oral mucosa
Test subjects: 60 men and women in 15-35 years old are randomly divided into 3 groups, each group has 40 people, each group uses a mouthwash, the mouthwash is used 1h after meal, each time gargles for 45s, and the specific results are tested after 3 months, and the table 5 shows.
Wherein, 20 patients have swollen and painful gums (the disease course is 3 months without damaged nerves), and 20 patients have damaged oral mucosa (the disease course is 3 months without damaged nerves);
the treatment effect is as follows: curative, effective and ineffective. The therapeutic effects obtained are shown in table 5.
TABLE 5 prevention and treatment effects of mouthwashes prepared in examples 1-3 on oral diseases
As can be seen from Table 5, the mouthwash provided by the invention has good prevention and treatment effects on gum swelling and pain and oral mucosa damage after being continuously used for 3 months, and in addition, the product is simple in manufacturing process, low in raw material price, universal, convenient to purchase, remarkable in effect, and has certain economical efficiency, practicability and social prospect in the future market.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (4)
1. The mouthwash containing the flavonoids in the artemisia argyi is characterized by mainly comprising the following components in parts by weight: 2-4 parts of folium artemisiae argyi flavone, 0.1-0.3 part of danshensu, 0.1-0.3 part of plant enzyme, 0.5-1 part of antibacterial agent, 1-2 parts of alkyl glycoside, 0.05-0.1 part of sodium carboxymethylcellulose, 0.4-0.6 part of dipotassium glycyrrhizinate, 0.3-0.5 part of vitamin C, 0.2-0.4 part of sodium chloride and 90-95 parts of water, wherein the plant enzyme is prepared from papain, bromelain and kelp enzyme according to a weight ratio of 2: 2: 1, wherein the antibacterial agent is prepared from nisin, epsilon-polylysine hydrochloride and glycine according to a weight ratio of 3: 2: 1.
2. The folium artemisiae argyi flavone-containing mouthwash according to claim 1, which is characterized by comprising the following components in parts by weight: 3 parts of folium artemisiae argyi flavone, 0.2 part of danshensu, 0.2 part of plant enzyme, 0.8 part of antibacterial agent, 1.5 parts of alkyl glycoside, 0.08 part of sodium carboxymethyl cellulose, 0.5 part of dipotassium glycyrrhizinate, 0.4 part of vitamin C, 0.3 part of sodium chloride and 92 parts of water.
3. The method for preparing the folium artemisiae argyi flavone-containing mouthwash according to claim 1 or 2, characterized by comprising the steps of: dissolving alkyl glycoside, sodium carboxymethylcellulose, dipotassium glycyrrhizinate, tanshinol and sodium chloride in water completely, heating to 50-60 ℃, stirring for 15-20min at the stirring speed of 100-.
4. Use of the folium artemisiae argyi flavone-containing mouthwash according to any one of claims 1 to 3 for the preparation of a medicament for the adjuvant treatment of oral mucosa damage.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710454065.7A CN107242983B (en) | 2017-06-15 | 2017-06-15 | Mouth wash containing folium artemisiae argyi flavone and preparation method thereof |
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| CN201710454065.7A CN107242983B (en) | 2017-06-15 | 2017-06-15 | Mouth wash containing folium artemisiae argyi flavone and preparation method thereof |
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| CN107242983A CN107242983A (en) | 2017-10-13 |
| CN107242983B true CN107242983B (en) | 2020-04-10 |
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| CN114557932A (en) * | 2022-03-03 | 2022-05-31 | 李时珍医药集团有限公司 | Toothpaste containing folium artemisiae argyi and rosemary leaf extracts and preparation method thereof |
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| CN102579313B (en) * | 2012-03-28 | 2013-12-25 | 罗妃 | External liquid preparation capable of preventing secondary chromatosis from happening after skin trauma operations |
| CN105326656A (en) * | 2015-10-29 | 2016-02-17 | 山东省药学科学院 | Oral antibacterial composition containing nisin and polylysine and preparation method thereof |
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