CN110433130A - A kind of male's basic nursing liquid - Google Patents
A kind of male's basic nursing liquid Download PDFInfo
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- CN110433130A CN110433130A CN201910904606.0A CN201910904606A CN110433130A CN 110433130 A CN110433130 A CN 110433130A CN 201910904606 A CN201910904606 A CN 201910904606A CN 110433130 A CN110433130 A CN 110433130A
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- herba epimedii
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The present invention relates to hygiene article sectors, and in particular to arrives a kind of male's basic nursing liquid.A kind of male's basic nursing liquid, it is to be made by traditional Chinese medicinal components and matrix components blended under agitation, pass through the natural components such as ginger, cloves, sea urchin, Herba Epimedii, Lavender, Rosemary Oil, ginseng, tea seed, vitamin E of compounding special ratios in traditional Chinese medicinal components in the present invention, further enhance the restraining and sterilizing bacteria effect of conditioning liquid, and reduce its stimulation to skin, make conditioning liquid while there is Quick itch stopping, dredging the channel, discharging garbage from body and other effects, keep privates clearly comfortable.In addition, playing the ingredient in the Herba Epimedii in traditional Chinese medicinal components, cloves, sea urchin etc. effectively by the solubilizer and stabilizer that compound special ratios in matrix components, helps to improve blood plasma testosterone content, promotes gonad function.
Description
Technical field
The present invention relates to hygiene article sectors, and in particular to arrives a kind of male's basic nursing liquid.
Background technique
With the promotion of people's living standard and the continuous enhancing of health perception, people increasingly pay attention to the health of itself
Situation is focused on to the cleaning-nursing at secret.Traditional concept thinks that female private part is more fragile, various diseases easy to breed
Bacterium, and male genitals are not necessarily to special care due to special physiological make-up, so being various feminine cares mostly currently on the market
Liquid, male's conditioning liquid is less, and function is more single.Actually this is not so, on the one hand since the dressing of male is more conservative, another party
The face physiological characteristic born due to male's privates, and there is no self-cleaning function, it is easier to many dirts are kept, harmful bacteria is bred,
If less clean position, it is easy to breed bacterium, such as Candida albicans, staphylococcus aureus etc., cause prostatitis etc.
Various inflammation, while the friendship of these bacterium passabilities is transmitted to women, so that maid's sexuality contaminates gynecological disease.Male cleans oneself
Privates can not only protect the health of oneself, moreover it is possible to protect sex partner, so that sexual life is kept harmonious, therefore, male is to private
The cleaning and nursing at place are also increasingly paid attention to, and are being continuously increased for the demand of the cleaning-nursing liquid of male, and protect to male
The requirement for managing liquid is also higher and higher.
Most of male's conditioning liquids currently on the market, primary efficacy can be added thus a certain amount of for sterilizing and itch-relieving
Western medicine composition, such as metronidazole, chlorhexidine etc., or addition have irritating traditional Chinese medicine ingredients to reach preferable sterilizing
Effect, but since the skin of male's privates is more delicate, it is more sensitive to these ingredients, when use can generate stimulation, calcination,
The discomforts such as itch can even cause allergic reaction, and these sterilization components are used for a long time to destroy the bacterium of human body privates sometimes
The ecological balance is fallen, its self-control and recovery capability is reduced, is unfavorable for human health.In addition, present people's life and work pressure
Larger, psychology and mental element cause male's sexual to decline, though drug therapy has certain effect, its dependence and pair
Effect can generate certain influence to human body psychology and health, and more conservative male but will evade treatment, therefore need
Want a kind of external wash liquid that routine is easily purchased come the needs of meeting them, but existing male's washing lotion effect is more single, does not have
There is the effect of improving male's sexual, and be not easy to rinse well, experience sense is poor.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of male's basic nursing liquid, the conditioning liquid is by Chinese medicine
Component and matrix components blended under agitation are made；
The traditional Chinese medicinal components include following parts by weight of component: 5~20 parts of Herba Epimedii, 2~10 parts of cloves, 1~7 part of ginger,
1~8 part of Lavender, 1~7 part of Rosemary Oil, 1~8 part of sea urchin, 1~6 part of ginseng, 1~10 part of tea seed, vitamin E 0
~6 parts；
The matrix components include following parts by weight of component: 2~20 parts of water, 2~15 parts of solubilizer, 1~8 part of stabilizer.
As a preferred technical solution of the present invention, the traditional Chinese medicinal components include following parts by weight of component: Herba Epimedii 10
~15 parts, 5~8 parts of cloves, 3~5 parts of ginger, 2~5 parts of Lavender, 1~5 part of Rosemary Oil, 2~5 parts of sea urchin, people
Join 1~3 part, 3~7 parts of tea seed, vitamin e1~3 part；The matrix components include following parts by weight of component: 5~15 parts of water increases
5~10 parts of solvent, 2~5 parts of stabilizer.
As a preferred technical solution of the present invention, the weight ratio of the Herba Epimedii and ginger is (1~5): 1.
As a preferred technical solution of the present invention, the weight ratio of the Herba Epimedii and ginger is 3:1.
As a preferred technical solution of the present invention, the weight ratio of the sea urchin and Herba Epimedii is 1:(2~6).
As a preferred technical solution of the present invention, the weight ratio of the sea urchin and Herba Epimedii is 1:4.
As a preferred technical solution of the present invention, the solubilizer is glycosyl carboxylate fluorocarbon surfactant and Shuangzi
Surfactant.
As a preferred technical solution of the present invention, the Gemini surface active agent and glycosyl metal carboxylate surface-active
The weight ratio of agent is 1:(3~5).
As a preferred technical solution of the present invention, the Gemini surface active agent and glycosyl metal carboxylate surface-active
The weight ratio of agent is 1:4.
As a preferred technical solution of the present invention, the Gemini surface active agent be by ASPARTIC ACID and N- just
The glucosyl group Gemini surface active agent that octyl-D-Glucose amine is prepared.
The utility model has the advantages that the conditioning liquid is by traditional Chinese medicinal components and matrix group the present invention provides a kind of male's basic nursing liquid
Point blended under agitation obtains, and includes a variety of natural traditional Chinese medicine extracts, wherein ginger component can be effectively suppressed and kill Escherichia coli, Portugal
The pathogenic microorganisms such as grape coccus, Pseudomonas aeruginosa reduce the Probability of the diseases such as the prostatitis caused by bacterium infection, and excessive
The sheep leaves of pulse plants peomotes the secretion of sperm, can improve male's sexual.In addition, special by being compounded in traditional Chinese medicinal components in the present invention
The natural components such as sea urchin, Lavender, Rosemary Oil, cloves, ginseng, tea seed, the vitamin E of certainty ratio further increase
The strong effect of conditioning liquid restraining and sterilizing bacteria, and ginger, Lavender etc. are reduced to the excitement of skin, burning sensation and dry
The various discomforts such as astringent sense make conditioning liquid while having effects that Quick itch stopping, dredging the channel, facilitate discharging garbage from body, make private
It is clearly comfortable to locate skin.In addition, the present invention makes Chinese medicine by the solubilizer and stabilizer of the compounding special ratios in matrix components
Ingredient in Herba Epimedii, cloves, sea urchin in component etc. effectively plays, and helps to improve blood plasma testosterone content, promotes sexual gland function
Energy.
Specific embodiment
The detailed description for preferred implementation method of the invention below of participating in the election of and including embodiment this hair can be more easily to understand
Bright content.Unless otherwise defined, all technologies used herein and scientific term have common with fields of the present invention
The normally understood identical meaning of technical staff.When there is a conflict, the definition in this specification shall prevail.
Term "comprising" used herein, " comprising ", " having ", " containing " or its any other deformation, it is intended that covering
Non-exclusionism includes.For example, composition, step, method, product or device comprising listed elements are not necessarily limited to those and want
Element, but may include not expressly listed other elements or such composition, step, method, product or device it is intrinsic
Element.
Equivalent, concentration or other values or parameter are excellent with range, preferred scope or a series of upper limit preferred values and lower limit
When the Range Representation that choosing value limits, this should be understood as specifically disclosing by any range limit or preferred value and any range
Any pairing of lower limit or preferred value is formed by all ranges, regardless of whether the range separately discloses.For example, when open
When range " 1 to 5 ", described range should be interpreted as including range " 1 to 4 ", " 1 to 3 ", " 1 to 2 ", " 1 to 2 and 4 to
5 ", " 1 to 3 and 5 " etc..When numberical range is described herein, unless otherwise stated, otherwise the range is intended to include its end
Value and all integers and score in the range.
In addition, indefinite article "an" before element of the present invention or component and "one" quantitative requirement to element or component
(i.e. frequency of occurrence) unrestriction.Therefore "one" or "an" should be read as including one or at least one, and odd number
The element or component of form also include plural form, unless the obvious purport of the quantity refers to singular.
Heretofore described male's basic nursing liquid is used for male's privates daily nursing.
Heretofore described conditioning liquid is made by traditional Chinese medicinal components and matrix components blended under agitation, and wherein traditional Chinese medicinal components include
Following parts by weight of component: 5~20 parts of Herba Epimedii, 2~10 parts of cloves, 1~7 part of ginger, 1~8 part of Lavender, rosemary essence
Oily 1~7 part, 1~8 part of sea urchin, 1~6 part of ginseng, 1~10 part of tea seed, 0~6 part of vitamin E；Matrix components include following weight
Part component: 2~20 parts of water, 2~15 parts of solubilizer, 1~8 part of stabilizer.
In a preferred embodiment, the traditional Chinese medicinal components include following parts by weight of component: 10~15 parts of Herba Epimedii,
5~8 parts of cloves, 3~5 parts of ginger, 2~5 parts of Lavender, 1~5 part of Rosemary Oil, 2~5 parts of sea urchin, ginseng 1~3
Part, 3~7 parts of tea seed, vitamin e1~3 part；The matrix components include following parts by weight of component: 5~15 parts of water, solubilizer 5
~10 parts, 2~5 parts of stabilizer.
In a kind of preferred embodiment, the traditional Chinese medicinal components include following parts by weight of component: 12 parts of Herba Epimedii, fourth
5.5 parts fragrant, 4 parts of ginger, 3.5 parts of Lavender, 3 parts of Rosemary Oil, 3.5 parts of sea urchin, 2 parts of ginseng, 5 parts of tea seed, dimension life
It is E2 parts plain；The matrix components include following parts by weight of component: 10 parts of water, 7.5 parts of solubilizer, 3.5 parts of stabilizer.
The preparation of heretofore described male's basic nursing liquid includes the following steps:
S1: Chinese medicine each component is stirred at 40~60 DEG C；
S2: it after matrix each component is mixed at room temperature, is added in the S1 that temperature is 40~60 DEG C, is stirred up to this
Invent male's basic nursing liquid.
Herba Epimedii
Herba Epimedii, also known as Epimedium, Herba Epimedii, lotusc orniculatus L., trident wind, triangle lotus, be Berberidaceae plant Herba Epimedii,
The cauline leaf of Epimedium brevicornum or Epimedium sagittatum, acrid-sweet flavor is warm-natured, returns liver and kidney channel, and the light gas of body is male, and can rise can drop, and has and mends
The effect of kidney and enhancing body, dispelling wind and eliminating dampness, strong muscles and bones.Containing a large amount of icariine, epimedium flavone time glucoside in Herba Epimedii, facilitate
Promote the secretion of sperm, improves male's sexual.
Herba Epimedii of the present invention can be commercially available, such as the Herba Epimedii being available commercially includes but is not limited to purchase
Buy in Xi'an Bao Yifeng Biotechnology Co., Ltd product (Herba Epimedii stem-leaf extract, it is faint yellow to brownish-yellow powder, content
For 98%).
Cloves
Heretofore described cloves is also known as flos caryophylli, is the dry flower of plant clove of myrtaceae, acrid flavour is warm-natured, returns
Stomach, spleen, kidney channel can be used to the symptoms such as impotence caused by treating because of kidney-yang deficiency, premature ejaculation, waist be cold, furthermore in cloves containing waving
Hair oil, oil in contain a large amount of eugenols, therefore have good antibacterial action, can kill well fungi, staphylococcus and
The mushrooms such as dysentery bacillus, and mildly have no stimulation, it can be used for treating the discomforts such as more common skin infections.
Cloves of the present invention can be commercially available, for example, the cloves being available commercially include but is not limited to buy in
The Shaanxi source Hui Kang biological medicine Science and Technology Ltd., article No. are the product (brown ceramic powder) of DX.
Ginger
Ginger, also known as ginger peel, ginger, race, Bailayun, another name for ginger, be Zingiber, zingiber herbaceos perennial fresh rhizome, i.e.,
Rhizoma zingiberis, acrid flavour, slightly warm in nature, return lung, spleen, stomach meridian.Contain zingiberol, zingiberene, phellandrene, citral, linalool, nonyl in ginger
The ingredients such as aldehyde, gingerol facilitate the inhibition of the pathogenic microorganisms such as Gold production staphylococcus, staphylococcus albus, Pseudomonas aeruginosa
With kill.
Ginger of the present invention can be commercially available, for example, the ginger being available commercially include but is not limited to buy in
Xi'an Ze Bang Biotechnology Co., Ltd, article No. be 78536764646 product (extract from the rhizome of Chinese catalpa zingiber, it is light
Yellow powder, content 10%).
Lavender
Lavender is refined by lavender, have clearing heat and detoxicating, cleaning skin, control oil, freckle removing and whitening,
The tender skin of anti-wrinkle, eye haustra -dsipelling black eye and other effects.In addition, in Lavender containing linalool, acetic acid linalool, cineole,
B- Luo Qin alkene has good antibacterial action to, ingredients such as acetic acid lavender ester, lavender alcohol, the pure and mild camphor of terpene -4-,
There is bacteriostasis to microorganisms such as Escherichia coli, bacillus subtilis, staphylococcus aureus, Mucor, trichoderma virides.
Lavender of the present invention can be commercially available, for example, the Lavender being available commercially include but
It is not limited to buy the product (water-soluble Lavender, faint yellow working fluid) in Jishui County Condar natural perfume material oil factory.
Rosemary Oil
Rosemary Oil is a kind of colourless to faint yellow volatile liquid refined from rosemary, is contained in main component
There are α-and nopinene, amphene, (R)-4-isopropenyl-1-methyl-1-cyclohexene, eucalyptus oil rope, dipentene, camphor, borneol, verbenone, bergamio, knot
The uncertain sesquiterpenoid etc. of structure has stronger astriction, can improve greasy unclean skin, and blood is promoted to follow
Ring mitigates dermohemia, edema, swelling etc..
Rosemary Oil of the present invention can be commercially available, for example, the Rosemary Oil being available commercially include but
Purchase is not limited in the permanent really natural perfume material oil Co., Ltd in Jiangxi, product that article No. is HCXL789 (extract from rosemary leaf and
Stem, weak yellow liquid).
Sea urchin
Sea urchin, also known as " Dragon Palace hedgehog ", with its gonad for food, gonad is also known as sea urchin egg, sea urchin seed, sea urchin Huang,
With nutritive value abundant, it is edible can medicine.Chinese medicine thinks that sea urchin egg taste is salty, mild-natured, the function with resolving hard lump, resolving sputum detumescence
Effect, while studying in discovery sea urchin egg containing the life active materials such as the distinctive structural proteins of a large amount of animal sexual glands, lecithin, tool
There is male sex hormone sample, sexual function can be improved and improve intelligence, monoglyceride, fatty olefin(e) acid are furthermore contained in sea urchin egg
The effective components such as cholesteryl ester, cholesterine, the campesterol of (such as 8,11,14- eicosatrienoic acids) help the antifouling equal function of antibacterial
Effect.
Sea urchin of the present invention can be commercially available, for example, the sea urchin being available commercially include but is not limited to buy in
The product (impurity 2% or so) of the new brightness medicine company in Shandong.
Ginseng
Heretofore described ginseng is ginseng adventitious root, is the adventitious root on Araliaceae ginseng roots, sweet in flavor, slight bitter,
Warm-natured, flat, returns spleen, lung channel, the heart channel of Hang-Shaoyin are known as the superfine product of " King of Herbs " " life is mended in enriching yin, is strengthened the body resistance to consolidate the constitution " from ancient times, contain a variety of soaps
Glucoside and polysaccharide component, leachate can expand capillary of skin, promote skin by skin slow-absorbing and without pessimal stimulation
Blood circulation increases skin-nourishing, adjusts the water and oil balance of skin, prevent skin dehydration, hardening, corrugation, ginseng active substance
The reducing property for inhibiting melanin, keeps skin pure white smooth, can enhance skin elasticity, obtains cell newborn, is to improve looks
Superfine product.
Ginseng can be commercially available in the present invention, such as the ginseng being available commercially includes but is not limited to buy in lake
Nan Langlin living resources limited liability company, article No. are the product of NAT-114.
Tea seed
Tea seed is the mature seed of Theaceae Camellia Plants tea tree, and the seed of tea oil tree can be divided into according to its growing state
With the seed of tea tree, i.e. tea seed and tea seeds, the two can extract oil.Tea-seed oil color is orange bright, fragrant, containing big
Measure unsaturated fatty acid, oleic acid, linoleic acid, the ingredients such as linolenic acid, with anti-aging, cleaning protection skin, improvement blood circulation
The effect of promoting endocrine function.
Tea seed of the present invention is tea-seed oil, can be commercially available, such as the tea seed being available commercially includes but not
It is limited to purchase in the permanent really natural perfume material oil Co., Ltd in Jiangxi, the product that article No. is HCXL4006 is (faint yellow saturating to yellow clarification
Prescribed liquid).
Vitamin E
Vitamin E is a kind of liposoluble vitamin, and it is one of most important antioxidant that hydrolysate, which is tocopherol,.
Vitamin E can promote sex hormone to secrete, and increase man's sperm motility and quantity, increase woman's female hormone concentration, improve
Fecundity, prevention of miscarriage.
Vitamin E of the present invention can be commercially available, such as the vitamin E being available commercially includes but unlimited
In purchase in Xi'an Long Mao Biotechnology Co., Ltd, the product (active principle content 99%) that article No. is 002.
In a preferred embodiment, the weight ratio of the Herba Epimedii and ginger is (1~5): 1；Preferably, institute
The weight ratio for stating Herba Epimedii and ginger is 3:1.
In a preferred embodiment, the weight ratio of the sea urchin and Herba Epimedii is 1:(2~6)；Preferably, institute
The weight ratio for stating sea urchin and Herba Epimedii is 1:4.
Containing ingredients such as zingiberol, zingiberene, phellandrene, citral, linalool, aldehyde C-9, gingerols in ginger, facilitate gold
It the inhibition of the pathogenic microorganisms such as color staphylococcus, Pseudomonas aeruginosa and kills.Contain a large amount of epimedium flavone glucoside, excessive in Herba Epimedii
Sheep leaves of pulse plants flavones time glucoside, peomotes the secretion of sperm, improves male's sexual.Contain monoglyceride, fatty olefin(e) acid in sea urchin
The effective components such as cholesteryl ester, cholesterine, the campesterol of (such as 8,11,14- eicosatrienoic acids) have the antifouling equal function of antibacterial
Effect.But due to the effective component in ginger in addition to have effects that it is above-mentioned other than, also have certain stimulation to skin, and
Under interaction between Lavender, Rosemary Oil etc., double to the stimulation of skin, burning sensation, therefore, just
The conditioning liquid being often used needs its dosage of strict control.And in the present invention it is found by the applicant that ginger, Herba Epimedii, leading between sea urchin
After crossing being used in compounding of specified weight ratio, while guaranteeing good bactericidal effect, moreover it is possible to significantly reduce conditioning liquid to flesh
Excitement, burning sensation and the sensation of dryness of skin, reduce the generation of side effect.At the same time, applicant further found that passing through mentioned component
Being used in compounding between specified weight ratio, moreover it is possible to remove odors, improve male's sexual.May be due to ginger, Herba Epimedii,
And similarity and complementarity between sea urchin effective component between molecular structure, the effects of forming stronger Van der Waals force power,
To the synthesis of the different kinds of proteins such as hemoglobin in reinforcement, while avoiding citral, linalool, aldehyde C-9, gingerol again etc.
Ingredient weakens bactericidal effect since stronger intramolecular active force is reunited, and has the function that synergy well.
In some embodiments, the solubilizer is glycosyl carboxylate fluorocarbon surfactant and Gemini surface active agent.
In a preferred embodiment, the weight of the glycosyl carboxylate fluorocarbon surfactant and Gemini surface active agent
Amount ratio is (3~5): 1；Preferably, the weight ratio of the glycosyl carboxylate fluorocarbon surfactant and Gemini surface active agent
For 4:1.
It is found by the applicant that select the solubilizer of above-mentioned specific compounding, can Quick itch stopping, male's privates of releiving is because of dermatitis
Various discomforts caused by disease etc.；Can also dredging the channel, facilitate discharging garbage from body, keep privates skin clearly comfortable.Applicant
Speculate that it may be the conditioning liquid due under the interaction between Gemini surface active agent and glycosyl metal carboxylate surface-active
Surface tension be effectively reduced, increase the dispersibility and dissolubility of wherein traditional Chinese medicinal components, keep these traditional Chinese medicinal components better
It sprawls and penetrates into inside skin, dredging the channel soothes the skin inflammation.In addition, used glycosyl metal carboxylate surface-active
The groups such as the glucosides in agent molecule structure are similar with the corresponding construction in effective component of chinese medicine, can preferably will be in traditional Chinese medicinal components
Effective component is dispersed and dissolves, Herba Epimedii, cloves, the sea urchin under the action of above-mentioned compounding solubilizer, in traditional Chinese medicinal components
The active force between effective component in is further improved, and helps to improve blood plasma testosterone content, promotes sexual gland function
Energy.It additionally aids the inhibition to microorganism fungus kinds such as Escherichia coli, Candida albicans, Penicillium notatums simultaneously and kills, make to sterilize energy
Power is significantly improved.
Glycosyl carboxylate fluorocarbon surfactant
Surfactant, which refers to, is added the substance that significant change occurs for the interface state that can make its solution system on a small quantity, has
Fixed hydrophilic lipophilic group, hydrophilic radical are often polar group, such as carboxylic acid, sulfonic acid, sulfuric acid, amino or amido and its salt,
It is wherein carboxylate fluorocarbon surfactant by the surfactant of hydrophilic radical of carboxylate.Using glucide and its ramification as raw material
The carboxylate fluorocarbon surfactant of synthesis is glycosyl carboxylate fluorocarbon surfactant.
Further, the glycosyl carboxylate fluorocarbon surfactant selects glucosides ester salt.
Glucosides ester salt
Glucosides ester salt is using glucide and its ramification as raw material, using carboxylate as hydrophilic radical, with the compound containing carbochain
For an analog anion surfactants of hydrophobic grouping.
Further, the glucosides ester salt selects cocoyl-glucoside tartrate sodium.
Cocoyl-glucoside tartrate sodium
Cocoyl-glucoside tartrate sodium is a kind of comparatively gentle surfactant, has certain cleaning function,
Also it is commonly used for emulsifier, keeps the lotion of cosmetics evenly dispersed.
Heretofore described cocoyl-glucoside tartrate sodium can be commercially available, such as be available commercially
Cocoyl-glucoside tartrate sodium includes but is not limited to buy in Jining backbone Information technology Co., Ltd, article No. ZJ-
253 product.
Gemini surface active agent
Gemini surface active agent, also known as Anionic Gemini Surfactant, geminal surfactant, be by chemical bond by two or
More than two same or almost same surfactant monomer, with connection base near hydrophilic head base or close hydrophilic head base
This amphiphilic composition is linked together by group, a kind of surfactant of formation.The hydrophilic radical of Gemini surface active agent is generally normal
For polar group, such as the anionics such as quaternary ammonium salt, amides, amine cationic or carboxylate, sulfate, it can also
To be that glucosides, polyalcohol etc. are non-ionic, Gemini surface active agent can be divided into according to hydrophilic radical by anionic, cation
Type, non-ionic gemini surface active agent, wherein non-ionic gemini surface active agent includes glycosyl Gemini surface active agent.
Further, the Gemini surface active agent selects glycosyl Gemini surface active agent.
Glycosyl Gemini surface active agent
Glycosyl Gemini surface active agent is that a kind of novel green surface using glucide and its ramification as Material synthesis is living
Property agent, such surfactant generally using glycosyl as hydrophilic group, can also with glycosyl be connection base.
Further, the glycosyl Gemini surface active agent selects glucosyl group Gemini surface active agent.
Glucosyl group Gemini surface active agent
Glucosyl group Gemini surface active agent is using glucose using its derivative as the Gemini surface active agent of Material synthesis.
Further, the Gemini surface active agent is by ASPARTIC ACID and N- n-octyl-D-Glucose amine preparation
Obtained by glucosyl group Gemini surface active agent.
In a preferred embodiment, the preparation of the glucosyl group Gemini surface active agent includes the following steps:
S1: acetone, water and L-Aspartic acid are added in the three-necked bottle with stirring, suitable triethylamine is added, adjusts pH
Di-tert-butyl dicarbonate is slowly added dropwise at 0 DEG C to 8~9 in value, the reaction was continued 2h.Reaction mixture removes acetone, residual solution under reduced pressure
It being extracted with ethyl acetate, water phase uses 1mol/L hydrochloric acid tune pH to 2~3 in ice bath, is washed with ethyl acetate, merge organic layer,
Saturated common salt water washing, anhydrous sodium sulfate are dry.Vacuum distillation, n-hexane recrystallization, be freeze-dried white powder uncle
Butoxy carbonyl-L-Aspartic acid.
S2: by tertbutyloxycarbonyl-L-Aspartic acid, N, N '-dicyclohexylcarbodiimide, n-hydroxysuccinimide are added
It fills in the three-necked bottle of methylene chloride, 2h is stirred in ice bath, 10h is stirred at room temperature.End of reaction is filtered to remove white precipitate, steams
Evaporate, solid is rinsed with ethyl alcohol, decompression filter, be freeze-dried white powder tertbutyloxycarbonyl-L-Aspartic acid Acibenzolar.
It takes Acibenzolar, N- n-octyl-D-Glucose amine to be added in the three-necked bottle for filling acetone, appropriate triethylamine tune solution is added dropwise to micro- alkali
Property, 30 DEG C are stirred to react 48h, and reaction mixture decompression filters, distillation removal solvent, are rinsed respectively with n-hexane and acetonitrile.It is cold
It is lyophilized dry, obtains white N- n-octyl-D-Glucose amine Gemini surface active agent.
It is found by the applicant that when using specific glucosyl group Gemini surface active agent as solubilizer, even with highly concentrated
The ingredients such as Rosemary Oil, Lavender, the cloves of degree, it is more sensitive for skin, it is easy to cause the uncomfortable use such as inflammation
Object will not cause the symptoms such as apparent allergy or discomfort.On the contrary, salubrious degree, comfort level are further enhanced.It may
It is the glucosyl group Gemini surface active agent molecule being prepared due to raw materials such as aspartic acid, N- n-octyl-D-Glucose amine
Glucosides in structure, the groups such as great amount of hydroxy group can adsorb the ingredient for easily causing stimulation and inflammation in traditional Chinese medicinal components, avoid these
The ingredient patch volt property high because of the specific region of its specific molecular structure and skin surface, causes skin surface region property high
Concentration high active ingredient effect, to cause inflammation and allergy.Moreover, by using ASPARTIC ACID by N- n-octyl-D-
Gucosamine connects, and enhances the interaction between n-octyl alkyl chain, simultaneously because on gucosamine molecular structure
The aquation of the hydrophilic radicals such as great amount of hydroxy group forms solubilization micelle, by the effective component of the easy cause allergy in traditional Chinese medicinal components
Cladding is got up, and avoids the effective component of high concentration from directly contacting with skin, so as to cause allergy and stimulation.Simultaneously as above-mentioned
The coating function of glucosyl group Gemini surface active agent, can be with the effective component rapid osmotic in conditioning liquid into skin
Portion can quickly play sterilization and releive and other effects, and due to slowly discharging effective component during infiltration, not hurt
And skin, moreover it is possible to the case where avoiding the absorption of effective component slow and can not playing original effect generation.
In a preferred embodiment, the stabilizer is PEG-60 rilanit special and hydroxyethyl cellulose；Institute
The weight ratio for stating PEG-60 rilanit special and hydroxyethyl cellulose is 1:1.
PEG-60 rilanit special
PEG-60 rilanit special is a kind of common efficient solubilizing agents, can be by essence, the oily matters such as essential oil, equably
It is distributed in water, forms stable, transparent solution.
PEG-60 rilanit special of the present invention can be commercially available, such as the PEG-60 hydrogenation being available commercially
Castor oil includes but is not limited to buy in Qingdao excellent rope chemistry Science and Technology Ltd., and (content is for product that article No. is 1271514
99%).
Hydroxyethyl cellulose
Hydroxyethyl cellulose is a kind of white or faint yellow, tasteless, nontoxic threadiness or pulverulent solids, is soluble in
Water has the characteristics such as good thickening, suspension, dispersion, emulsification, and No. CAS is 9004-62-0.
Hydroxyethyl cellulose of the present invention can be commercially available, such as the hydroxyethyl cellulose packet being available commercially
It includes but is not limited to purchase in the luxuriant chemical products firm in Zhengzhou City Jinshui District, the product that article No. is 113.
Stabilizer in the present invention selects PEG-60 rilanit special and hydroxyethyl cellulose, with Gemini surface active agent and
By Herba Epimedii, cloves, ginger, ginseng, sea urchin, essential oil etc. under interaction between glycosyl carboxylate fluorocarbon surfactant etc.
Effective component in traditional Chinese medicinal components is evenly dispersed, forms the conditioning liquid of stable homogeneous, avoids conditioning liquid in environment such as higher temperatures
The unstable situations such as lower appearance flocculation, precipitating.Simultaneously as under interaction between above-mentioned specific components, it being capable of shape
At more stable, uniform micella, the effective component in traditional Chinese medicinal components preferably can be coated and be sustained by these micellas, be avoided
While stimulation and allergy that the ingredients such as high concentration essential oil directly occur with human contact, additionally it is possible to keep these ingredients better
Synergy improves prostate bactericidal property and salubrious comfort.
Embodiment
Embodiment 1
Embodiment 1 provides a kind of male's basic nursing liquid, and the conditioning liquid is stirred by traditional Chinese medicinal components and matrix components
It is blended and is made；The traditional Chinese medicinal components include following parts by weight of component: 5 parts of Herba Epimedii, 2 parts of cloves, 1 part of ginger, Lavender 1
Part, 1 part of Rosemary Oil, 1 part of sea urchin, 1 part of ginseng, 1 part of tea seed；The matrix components include following parts by weight of component: water 2
Part, 2 parts of solubilizer, 1 part of stabilizer.
The Herba Epimedii purchase is in Xi'an Bao Yifeng Biotechnology Co., Ltd；The cloves purchase is raw in the Shaanxi source Hui Kang
Object Pharmaceutical Technology Co., Ltd, article No. DX；In Xi'an Ze Bang Biotechnology Co., Ltd, article No. is for the ginger purchase
78536764646；The Lavender purchase is in Jishui County Condar natural perfume material oil factory；The Rosemary Oil purchase is in river
Western permanent really natural perfume material oil Co., Ltd, article No. HCXL789；The sea urchin purchase is in the new brightness medicine company in Shandong；The ginseng purchase
It buys in Hunan Lang Lin living resources limited liability company, article No. NAT-114；The tea seed purchase is in the permanent sincere natural perfume material in Jiangxi
Oily Co., Ltd, article No. HCXL4006；In Xi'an Long Mao Biotechnology Co., Ltd, article No. is for the vitamin E purchase
002。
The solubilizer is glucosyl group Gemini surface active agent and cocoyl-glucoside tartrate sodium, the two weight
Than for 1:3.
The cocoyl-glucoside tartrate sodium purchase is in Jining backbone Information technology Co., Ltd, article No. ZJ-
253。
The preparation of the glucosyl group Gemini surface active agent includes the following steps:
S1: 40ml acetone, 4mL water and 10mmol L-Aspartic acid are added in the 100mL three-necked bottle with stirring, added
Enter suitable triethylamine, adjusts pH value to 8,11mmol di-tert-butyl dicarbonate is slowly added dropwise at 0 DEG C, the reaction was continued 2h.Reaction is mixed
It closes liquid and removes acetone under reduced pressure, residual solution is extracted with ethyl acetate, and water phase uses 1mol/L hydrochloric acid tune pH to 2 in ice bath, uses acetic acid
Ethyl ester washing merges organic layer, saturated common salt water washing, anhydrous sodium sulfate drying.Vacuum distillation, n-hexane recrystallization, freezing
Tertbutyloxycarbonyl-L-Aspartic acid of dry white powder.
S2: by 7.5mmol tertbutyloxycarbonyl-L-Aspartic acid, 15mmol N, N '-dicyclohexylcarbodiimide, 15mmol
N-hydroxysuccinimide is added in the 250mL three-necked bottle for filling 100ml methylene chloride, and 2h is stirred in ice bath, is stirred at room temperature
10h.End of reaction is filtered to remove white precipitate, and distillation, solid is rinsed with ethyl alcohol, and decompression filters, and is freeze-dried to obtain white powder
The tertbutyloxycarbonyl of shape-L-Aspartic acid Acibenzolar.1g Acibenzolar, 2mol N- n-octyl-D-Glucose amine addition is taken to fill
In the 250mL three-necked bottle of 90mL acetone, appropriate triethylamine tune solution is added dropwise to alkalescence, 30 DEG C are stirred to react 48h, reaction mixing
Liquid decompression filters, and distillation removal solvent is rinsed with n-hexane and acetonitrile respectively.Freeze-drying, obtains the white Portugal N- n-octyl-D-
Grapes glucosamine Gemini surface active agent.
The stabilizer be PEG-60 rilanit special and hydroxyethyl cellulose, the two weight ratio be 1:1, buy respectively in
Qingdao excellent rope chemistry Science and Technology Ltd., article No. is 1271514 and the luxuriant chemical products firm in Zhengzhou City Jinshui District, article No. are
113。
The preparation of male's basic nursing liquid includes the following steps:
S1: Chinese medicine each component is stirred at 50 DEG C；
S2: it at room temperature after mixing by matrix each component, is added in the S1 that temperature is 50 DEG C, is stirred up to this
Invent male's basic nursing liquid.
Embodiment 2
Embodiment 2 provides a kind of male's basic nursing liquid, and the conditioning liquid is stirred by traditional Chinese medicinal components and matrix components
It is blended and is made；The traditional Chinese medicinal components include following parts by weight of component: 20 parts of Herba Epimedii, 10 parts of cloves, 7 parts of ginger, lavender essence
Oily 8 parts, 7 parts of Rosemary Oil, 8 parts of sea urchin, 6 parts of ginseng, 10 parts of tea seed, 6 parts of vitamin E；The matrix components include as follows
Parts by weight of component: 20 parts of water, 15 parts of solubilizer, 8 parts of stabilizer.
The solubilizer is glucosyl group Gemini surface active agent and cocoyl-glucoside tartrate sodium, the two weight
Than for 1:5.
Other are the same as embodiment 1.
Embodiment 3
Embodiment 3 provides a kind of male's basic nursing liquid, and the conditioning liquid is stirred by traditional Chinese medicinal components and matrix components
It is blended and is made；The traditional Chinese medicinal components include following parts by weight of component: 10 parts of Herba Epimedii, 5 parts of cloves, 3 parts of ginger, Lavender
2 parts, 1 part of Rosemary Oil, 2 parts of sea urchin, 1 part of ginseng, 3 parts of tea seed, 7 parts of vitamin E；The matrix components include following weight
Measure part component: 5 parts of water, 5 parts of solubilizer, 2 parts of stabilizer.
The solubilizer is glucosyl group Gemini surface active agent and cocoyl-glucoside tartrate sodium, the two weight
Than for 1:4.
Other are the same as embodiment 1.
Embodiment 4
Embodiment 4 provides a kind of male's basic nursing liquid, and the conditioning liquid is stirred by traditional Chinese medicinal components and matrix components
It is blended and is made；The traditional Chinese medicinal components include following parts by weight of component: 15 parts of Herba Epimedii, 8 parts of cloves, 5 parts of ginger, Lavender
5 parts, 5 parts of Rosemary Oil, 5 parts of sea urchin, 3 parts of ginseng, 7 parts of tea seed, 3 parts of vitamin E；The matrix components include following weight
Measure part component: 15 parts of water, 10 parts of solubilizer, 5 parts of stabilizer.
The solubilizer is glucosyl group Gemini surface active agent and cocoyl-glucoside tartrate sodium, the two weight
Than for 1:4.
Other are the same as embodiment 1.
Embodiment 5
Embodiment 5 provides a kind of male's basic nursing liquid, and the conditioning liquid is stirred by traditional Chinese medicinal components and matrix components
It is blended and is made；The traditional Chinese medicinal components include following parts by weight of component: 12 parts of Herba Epimedii, 6 parts of cloves, 4 parts of ginger, Lavender
4 parts, 3 parts of Rosemary Oil, 3 parts of sea urchin, 2 parts of ginseng, 5 parts of tea seed, 2 parts of vitamin E；The matrix components include following weight
Measure part component: 10 parts of water, 8 parts of solubilizer, 4 parts of stabilizer.
The solubilizer is glucosyl group Gemini surface active agent and cocoyl-glucoside tartrate sodium, the two weight
Than for 1:4.
Other are the same as embodiment 1.
Embodiment 6
Compared with Example 5, the parts by weight of ginger are 12 parts to embodiment 6 in traditional Chinese medicinal components, other are same as Example 5.
Embodiment 7
Compared with Example 5, without ginger in traditional Chinese medicinal components, other are same as Example 5 for embodiment 7.
Embodiment 8
Compared with Example 5, the parts by weight of sea urchin are 12 parts to embodiment 8 in traditional Chinese medicinal components, other are same as Example 5.
Embodiment 9
Compared with Example 5, without sea urchin in traditional Chinese medicinal components, other are same as Example 5 for embodiment 9.
Embodiment 10
Embodiment 10 compared with Example 5, cocoyl-glucoside tartrate sodium and glucosyl group Shuangzi in matrix components
The weight ratio of surfactant is 1:1, other are same as Example 5.
Embodiment 11
Embodiment 11 compared with Example 5, cocoyl-glucoside tartrate sodium and glucosyl group Shuangzi in matrix components
The weight ratio of surfactant is 6:1, other are same as Example 5.
Embodiment 12
Glucosyl group Gemini surface active agent compared with Example 5, is replaced with cocoyl-in matrix components by embodiment 12
Glucoside tartrate sodium, other are same as Example 5.
Embodiment 13
Cocoyl-glucoside tartrate sodium compared with Example 5, is replaced with glucose in matrix components by embodiment 13
Base Gemini surface active agent, other are same as Example 5.
Embodiment 14
Glucosyl group Gemini surface active agent compared with Example 5, is replaced with Shuangzi sun in matrix components by embodiment 14
Ionic surface active agent (purchase is in Shanghai Shen Rong Chemical Industry Science Co., Ltd), other are same as Example 5.
Embodiment 15
PEG-60 rilanit special compared with Example 5, is replaced with hydroxyethyl cellulose in matrix components by embodiment 15,
Other are same as Example 5.
Embodiment 16
Hydroxyethyl cellulose compared with Example 4, is replaced with PEG-60 rilanit special in matrix components by embodiment 16,
Other are same as Example 5.
Embodiment 17
Compared with Example 4, without cloves in traditional Chinese medicinal components, other are same as Example 5 for embodiment 17.
Embodiment 18
Compared with Example 4, without Lavender in traditional Chinese medicinal components, other are same as Example 5 for embodiment 18.
Performance evaluation
1, fungistatic effect
Referring to " sterile products Hygienic safety evaluation technical requirements " WS 628-2018 and disinfection technology standard (2002 years
Version), extracorporeal bacteria inhibitor test is carried out to the male's basic nursing liquid prepared in embodiment.
(1) material and bacteria suspension preparation
1) test strain
Escherichia coli (8099 or ATCC 11229), staphylococcus aureus (ATCC6538), Candida albicans
(ATCC10231), Penicillium notatum clinical separation strain.
2) preparation of bacteria suspension
Strain tube is opened in a manner of sterile working, and adequate nutrition broth bouillon, soft pressure-vaccum number is added with capillary syring
It is secondary, so that strain is melted dispersion.The test tube containing 5.0~10.0mL nutrient broth medium is taken, a little bacteria suspension is instilled, sets 37 DEG C of trainings
Feeding 18~for 24 hours.Take the bacteria suspension of 1st generation culture with oese, streak inoculation is on nutrient agar plate, setting 37 DEG C of trainings
Feeding 18~for 24 hours.Or from microbank take out a bacterium pearl be inoculated on plate, set 37 DEG C culture 18~for 24 hours, picking is above-mentioned
Colonies typical in 2nd generation culture, is inoculated in nutrient agar slopes, set 37 DEG C culture 18~for 24 hours, as the 3rd generation culture.Weight
Multiple several generations.The fresh slant culture for taking the nutrient agar culture 18 in the 3rd~6 generation~for 24 hours, is drawn with 5.0mL suction pipe
3.0~5.0mL dilution (generally using TPS, acidifying water physiological saline) is added in slant tube, and pressure-vaccum, washes lower lawn repeatedly.
Then, washing lotion is moved in another sterile test tube with 5.0mL suction pipe, with electronic vortex mixer mixing 20s, or rapping 80 on palm
It is secondary, so that bacterial suspension is uniform.Bacteria suspension made of preliminary, first with the bigness scale of bacterial concentration nephelometry, it contains bacteria concentration, so
Afterwards with diluted to required concentration.
(2) bacteriostatic test
1) preparation of bacteria inhibition tablet
Sterile and dry filter paper is taken, every is added dropwise the about 5 μ L of male's basic nursing liquid prepared in embodiment respectively, so
Filter paper is lain against in clean sterilized petri dishes afterwards, uncaps to set in constant incubator (37 DEG C) and dry, or is set natural at room temperature
It is spare after drying.
2) inoculation of test organisms
Dipping concentration with sterile cotton swab is that 5 × 105~5 × 106cfu/mL tests bacteria suspension, in nutrient agar
Planar surface is uniformly smeared 3 times.Every to smear 1 time, plate should rotate 60 °, finally smear cotton swab one week around plate edge.Lid
Good plate, sets drying at room temperature 5min.
3) bacteriostatic agent print is placed with
Test is placed with 1 microbiological contamination plate every time, and each plate is placed with 4 test prints.It is placed with aseptic nipper coupongs
In planar surface.At a distance of 25mm or more between each print center, the periphery with plate is at a distance of 15mm or more.After being placed with, with nothing
The light pressure-like piece of bacterium tweezers, makes it be tightly attached to planar surface.Plate is covered, 37 DEG C of constant incubators, culture 16~18h observation knot are set
Fruit.With the diameter (including patch) of vernier caliper measurement antibacterial ring size and record.Test is repeated 3 times, and records and calculates average value.
(3) evaluation regulation
1) bacteriostasis judges
Inhibition zone diameter is greater than 7mm person, has been judged to bacteriostasis；Inhibition zone diameter is less than or equal to 7mm person, is judged to no suppression
Bacterium effect.
2) 3 repetition tests, which reach, bacteriostasis result person, is judged to qualification.
(4) fungistatic effect
Table 1 is bacteriostatic diameter (mm) of the different groups of male's basic nursing liquid to different microorganisms.
The test of 1 bacteriostasis property of table
2, using organoleptic test
72 test males are equally divided into 18 groups, give test group sample at random by " double blind " test, it is desirable that tester
Member uses (i.e. the dosage of male's conditioning liquid, usage mode, flushing period is without limitation) by itself daily habits, and successively evaluation makes
Irritation, salubrious degree, cleaning force.Tester according to oneself feel score, standards of grading using 5 points system, wherein
Irritation is with 1 point to be best, and 5 points are worst calculating, and salubrious degree and cleaning force are worst with 1 point, and 5 points preferably calculate, finally with flat
Equal records of values each group sensory effects scoring, is shown in Table 2.
3, stability
(high temperature) is placed 6 months at a temperature of conditioning liquid obtained in embodiment is respectively placed in room temperature and 40 DEG C, at 6
Month when observation nursing liquid whether go bad, than such as whether water-oil separation, condensation cure, thinning change water phenomenon and color occur gentle
Whether taste changes.10 test mans according to it is above-mentioned it is rotten description respectively to every group of conditioning liquid room temperature and high temperature stability
Score, standards of grading are using 5 points of systems, wherein with 1 point to be worst, 5 points preferably to calculate, it is finally each with mean values record
Stability scoring under group room temperature and high temperature, is shown in Table 2.
Table 2 uses organoleptic test and estimation of stability
According to embodiment 1-6 in table 1 as it can be seen that special component and ratio compound in the present invention traditional Chinese medicinal components and matrix components
So that male's basic nursing liquid has preferable bacteriostasis.In addition, according to table 2 as it can be seen that conditioning liquid is not only in the present invention
It is mildly non-stimulated, and there is preferable salubrious degree and cleaning force, embodiment 1-6 and embodiment 7-18 is as it can be seen that originally in contrast table 2
Prepared conditioning liquid has preferable stability under room temperature and hot conditions in invention, is unlikely to deteriorate, relatively more strong to human body
Health.
Example above-mentioned is merely illustrative, and is used to explain the present invention some features of the method.Appended right is wanted
The range as wide as possible for being intended to require to be contemplated that is sought, and embodiments as presented herein is only according to all possible implementation
The explanation of the embodiment of the combined selection of example.Therefore, the purpose of applicant is that the attached claims are not illustrated this hair
The exemplary selectional restriction of bright feature.Some numberical ranges used also include sub- model in the claims
It encloses, the variation in these ranges should also be construed to be covered by the attached claims in the conceived case.
Claims (10)
1. a kind of male's basic nursing liquid, which is characterized in that the conditioning liquid is by traditional Chinese medicinal components and matrix components blended under agitation
It is made；
The traditional Chinese medicinal components include following parts by weight of component: 5~20 parts of Herba Epimedii, 1~7 part of ginger, smokes clothing at 2~10 parts of cloves
1~8 part of careless essential oil, 1~7 part of Rosemary Oil, 1~8 part of sea urchin, 1~6 part of ginseng, 1~10 part of tea seed, vitamin E 0~6
Part；
The matrix components include following parts by weight of component: 2~20 parts of water, 2~15 parts of solubilizer, 1~8 part of stabilizer.
2. male's basic nursing liquid according to claim 1, which is characterized in that the traditional Chinese medicinal components include following parts by weight
Component: 10~15 parts of Herba Epimedii, 5~8 parts of cloves, 3~5 parts of ginger, 2~5 parts of Lavender, 1~5 part of Rosemary Oil,
2~5 parts of sea urchin, 1~3 part of ginseng, 3~7 parts of tea seed, vitamin e1~3 part；
The matrix components include following parts by weight of component: 5~15 parts of water, 5~10 parts of solubilizer, 2~5 parts of stabilizer.
3. male's basic nursing liquid according to claim 2, which is characterized in that the weight ratio of the Herba Epimedii and ginger
For (1~5): 1.
4. male's basic nursing liquid according to claim 3, which is characterized in that the weight ratio of the Herba Epimedii and ginger
For 3:1.
5. male's basic nursing liquid according to claim 4, which is characterized in that the weight ratio of the sea urchin and Herba Epimedii
For 1:(2~6).
6. male's basic nursing liquid according to claim 5, which is characterized in that the weight ratio of the sea urchin and Herba Epimedii
For 1:4.
7. male's basic nursing liquid according to claim 1 or 2, which is characterized in that the solubilizer is glycosyl carboxylate
Class surfactant and Gemini surface active agent.
8. male's basic nursing liquid according to claim 7, which is characterized in that the Gemini surface active agent and glycosyl carboxylic
The weight ratio of Barbiturates surfactant is 1:(3~5).
9. male's basic nursing liquid according to claim 8, which is characterized in that the Gemini surface active agent and glycosyl carboxylic
The weight ratio of Barbiturates surfactant is 1:4.
10. male's basic nursing liquid according to claim 9, which is characterized in that the Gemini surface active agent is by L-
The glucosyl group Gemini surface active agent that asparatate and N- n-octyl-D-Glucose amine are prepared.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112842970A (en) * | 2021-03-29 | 2021-05-28 | 重庆文理学院 | Children skin lotion and preparation method and application thereof |
| CN114762673A (en) * | 2021-05-10 | 2022-07-19 | 山东华中生物科技有限公司 | Preparation method of private care solution |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112842970A (en) * | 2021-03-29 | 2021-05-28 | 重庆文理学院 | Children skin lotion and preparation method and application thereof |
| CN114762673A (en) * | 2021-05-10 | 2022-07-19 | 山东华中生物科技有限公司 | Preparation method of private care solution |
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Application publication date: 20191112 |