CN110403891B - A Chinese herbal toothpaste with oral health promoting effect - Google Patents
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Abstract
The invention discloses a Chinese herbal medicine toothpaste, which is prepared by taking a decocting extraction solution of Chinese herbal medicines as an active ingredient and adding auxiliary materials or auxiliary ingredients acceptable in daily chemicals; the decoction extract is an extract prepared by filtering and concentrating decoction water extract of the Chinese herbal medicines. The functional components of the invention are derived from natural plants, the used Chinese herbal medicines are few in variety, no chemical reaction occurs, and the effects of preventing and treating oral erosion, oral ulcer, inflammation and dental caries can be exerted to the maximum extent; the gallic acid has high stability in acidic matrix of toothpaste.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to an anti-inflammatory, hemostatic and analgesic Chinese herbal medicine toothpaste with the effects of preventing oral erosion, oral ulcer and dental caries and a preparation process thereof.
Background
With the abundance of food types, the incidence of dental caries is increasing. Toothpastes incorporating chemicals such as sodium fluoride, strontium fluoride, etc. are called fluoride toothpastes, and these fluorides enhance the tooth's ability to resist dental caries, but are not used blindly or for long periods of time. In some regions, the fluorine content in water is too high, and people can cause chronic fluorosis after drinking the water for a long time. Yellow dental plaque appears on teeth after poisoning, and also can cause fluorosis to cause humpback. In these areas, one can of course not use a toothpaste containing fluorine. Moreover, the tooth brushing and gargling skills of babies are not completely mastered, the children cannot avoid the situation of swallowing by mistake when brushing teeth, and the children toothpaste needs to adopt a low-fluorine or fluorine-free formula. Therefore, other anti-caries toothpastes need to be developed.
Although the oral ulcer does not affect the normal life of people, a lot of pain and trouble are added, and the oral ulcer is caused by irregular eating and sleeping, high working pressure, fatigue and tension, low mood, picky food, bad appetite, poor body constitution and immunity and other factors, and is the oral mucosa localized ulcer injury which can occur at any part of the oral mucosa and is characterized by periodic repeated attack. The oral ulcer also has the characteristics of relapse and self-limitation, and even can influence the appetite, thereby causing inconvenience to the daily diet of people.
The Chinese herbal medicine extract or the active ingredients thereof are added into the toothpaste matrix, so that the requirement of cleaning the oral cavity is met, and other prevention and health care effects are added to the Chinese herbal medicine toothpaste, but at present, the research of using the Chinese herbal medicine decoction for toothpaste to prevent and treat oral diseases, particularly oral ulcer and dental caries is not available.
Disclosure of Invention
In order to solve the problems, the invention provides a Chinese herbal medicine toothpaste, which is prepared by taking a decoction of Chinese herbal medicines extracting solution as an active ingredient and adding auxiliary materials or auxiliary ingredients acceptable in daily chemicals;
the Chinese gall leaven extracting solution is an extract prepared by filtering and concentrating Chinese gall leaven water extracting solution.
Further, the feed additive is composed of the following raw materials in parts by weight:
40-60 parts of a hundred-medicine decoction extract and 40-60 parts of a toothpaste matrix.
Furthermore, the relative density of the decoction extract of the Chinese herbal medicines is 1.1-1.3.
Further, the toothpaste matrix is composed of the following auxiliary materials in percentage by mass:
45-55% of silicon dioxide, 10-13% of glycerol, 3-5% of xanthan gum, 1-3% of carboxymethyl cellulose, 1-3% of carbomer, 3-5% of sodium lauryl sulfate, 0.5-0.9% of calcium hydrophosphate, 0.5-1.5% of methyl hydroxybenzoate, 0.5-1.5% of saccharin sodium, 2-4% of peppermint oil, 2-4% of orange oil and the balance of water. Furthermore, the toothpaste matrix is composed of the following auxiliary materials in percentage by mass:
50% of silicon dioxide, 12% of glycerol, 4% of xanthan gum, 2% of carboxymethyl cellulose, 2% of carbomer, 4% of sodium lauryl sulfate, 0.7% of calcium hydrophosphate, 1% of methylparaben, 1% of saccharin sodium, 3% of peppermint oil, 3% of orange oil and the balance of water.
Further, the water is deionized water.
The invention also provides a preparation method of the Chinese herbal medicine decoction extract, which comprises the following steps:
decocting the Chinese herbal medicines with 7-10 times of water for 3 times, wherein each time lasts for 1.5-2.0 h, filtering, and concentrating the filtrate at 70 ℃ under reduced pressure until the relative density is 1.2 to obtain the Chinese herbal medicine.
The invention also provides a method for preparing the toothpaste, which comprises the following steps:
1) weighing the hundred-medicine decoction extract and the toothpaste matrix according to the proportion;
2) mixing the raw materials in the step 1), and shearing and homogenizing to obtain the product.
Further, the shearing homogenization rate is 20000r/min, the pressure is 100MPa, and the cycle time is 8 times.
The invention also provides an application of the toothpaste in preparing daily chemical products for preventing oral erosion.
The invention also provides an application of the toothpaste in preparing daily chemicals for preventing dental ulcer.
The invention also provides an application of the toothpaste in preparing daily chemicals for preventing oral inflammation.
The invention finally provides the application of the toothpaste in preparing daily chemical products for preventing decayed teeth.
The functional components of the Baiyao decocted toothpaste are derived from natural plants, the used Chinese herbal medicines are few in variety, no chemical reaction occurs, the effects of preventing and treating oral erosion, oral ulcer, inflammation and dental caries can be exerted to the maximum extent, and the functional components of the gallic acid in the gallic acid toothpaste matrix have high effect stability.
In vitro anti-inflammatory, analgesic and hemostatic experiments show that the Chinese herbal medicine toothpaste has obvious anti-inflammatory, analgesic and hemostatic effects; can quickly heal the dental ulcer; can play a good role in preventing and treating decayed teeth, has fresh and cool mouthfeel and excellent health-care and treatment effects.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
Example 1 preparation of the extract of the invention
Decocting 10g of the Chinese herbal medicines with 100ml of water for 3 times, each time for 2 hours, filtering, and concentrating the filtrate at 70 ℃ under reduced pressure to obtain an extract with the relative density of 1.2.
Example 2 preparation of the extract of the invention
Decocting 10g of the Chinese herbal medicines with 70ml of water for 3 times, each time for 1.5h, filtering, and concentrating the filtrate at 70 ℃ under reduced pressure to obtain an extract with the relative density of 1.2.
Example 3 preparation of a toothpaste according to the invention
Formulation of
50g of the Baiyao decoction extract and 50g of toothpaste matrix (the toothpaste matrix consists of 50 percent of silicon dioxide, 12 percent of glycerin, 4 percent of xanthan gum, 2 percent of carboxymethyl cellulose, 2 percent of carbomer, 4 percent of sodium lauryl sulfate, 0.7 percent of calcium hydrophosphate, 1 percent of methyl hydroxybenzoate, 1 percent of saccharin sodium, 3 percent of peppermint oil, 3 percent of orange oil and the balance of deionized water)
The preparation method comprises the following steps:
1) weighing the decoction extract and the toothpaste matrix according to the proportion;
2) mixing the raw materials, shearing and homogenizing (speed of 20000r/min, pressure of 100MPa, and circulating for 8 times).
Example 4 preparation of a toothpaste according to the invention
Formulation of
40g of the Baiyao decoction extract and 60g of toothpaste matrix (the toothpaste matrix consists of 50 percent of silicon dioxide, 12 percent of glycerin, 4 percent of xanthan gum, 2 percent of carboxymethyl cellulose, 2 percent of carbomer, 4 percent of sodium lauryl sulfate, 0.7 percent of calcium hydrophosphate, 1 percent of methyl hydroxybenzoate, 1 percent of saccharin sodium, 3 percent of peppermint oil, 3 percent of orange oil and the balance of deionized water)
The preparation method comprises the following steps:
1) weighing the decoction extract and the toothpaste matrix according to the proportion;
2) mixing the raw materials, shearing and homogenizing (speed of 20000r/min, pressure of 100MPa, and circulating for 8 times).
Example 5 preparation of a toothpaste according to the invention
Formulation of
The weight percentage of the decocted herbal medicine extract is 60g, and the toothpaste matrix is 40g (the toothpaste matrix comprises 50% of silicon dioxide, 12% of glycerol, 4% of xanthan gum, 2% of carboxymethyl cellulose, 2% of carbomer, 4% of sodium lauryl sulfate, 0.7% of calcium hydrophosphate, 1% of methylparaben, 1% of saccharin sodium, 3% of peppermint oil, 3% of orange oil and the balance of deionized water)
The preparation method comprises the following steps:
1) weighing the decoction extract and the toothpaste matrix according to the proportion;
2) mixing the raw materials, shearing, and homogenizing (speed 20000r/min, pressure 100MPa, circulation for 8 times).
The advantageous effects of the present invention are described below by way of test examples.
Experimental example 1 efficacy comparison study of Baiyao decocted toothpaste and Yunnan white powder toothpaste
First, research purpose
The observation and test shows that the toothpaste (containing the decoction extract of the Chinese herbal medicines) and the Yunnan white drug powder toothpaste have the effects of resisting inflammation, stopping bleeding, promoting ulcer healing and preventing and treating dental caries.
II, testing the sample
1. A multi-drug toothpaste [ 100% toothpaste sample (toothpaste prepared in example 3), 75% toothpaste sample (toothpaste prepared in example 3 mixed with toothpaste base at 3: 1), 50% toothpaste sample (toothpaste prepared in example 3 mixed with toothpaste base at 1: 1), 25% toothpaste sample (toothpaste prepared in example 3 mixed with toothpaste base at 1: 3), 10% toothpaste sample (toothpaste prepared in example 3 mixed with toothpaste base at 1: 9), wherein the toothpaste base consists of: 50% silicon dioxide, 12% glycerol, 4% xanthan gum, 2% carboxymethylcellulose, 2% carbomer, 4% sodium lauryl sulfate, 0.7% calcium hydrogen phosphate, 1% methyl hydroxybenzoate, 1% saccharin sodium, 3% peppermint oil, 3% orange oil, and the balance deionized water); 120 g/piece, prepared by processing laboratories of Chengdu Chinese medicine university.
2. Yunnan white drug powder toothpaste (Spearmint type), 180 g/piece, batch number: 20181229F19, available from Yunnan white drug products group Ltd.
3. A blank matrix of the Baiyao decocted toothpaste is prepared by processing laboratories of Chengdu traditional Chinese medicine university.
Third, research methods and results
1. Anti-inflammatory action
1.1 Effect of Paraxylene on swelling of mouse auricles
(1) The method comprises the following steps:
the experiment was divided into 4 groups (10/group) each of which was: firstly, a model control group is given physiological saline; ② decocting toothpaste group with various Chinese herbal medicines; ③ Yunnan white-drug toothpaste group; and fourthly, a negative control group (a blank matrix group of the hundred-drug-decocting toothpaste).
After all mice are bred adaptively for 3 days, 20 mu L of dimethylbenzene is uniformly coated on the right ears of the mice, 0.2g of toothpaste, matrix or 0.2mL of physiological saline is uniformly coated on the inflamed right ears after 30min, the mice are killed after 1h of continuous action, and the ears on the left and the right sides are cut off. And taking down the two circular lug pieces at the same positions of the two lug pieces by using a puncher with the diameter of 8mm, and precisely weighing the weight of the two circular lug pieces. The difference (mg) between the weight of the right ear minus the weight of the left ear was taken as the degree of swelling.
The inflammation inhibition ratio (%) is [ (degree of swelling in control group-degree of swelling in administration group)/degree of swelling in control group ] × 100%.
(2) As a result: see table 1.
TABLE 1 Effect of herbal toothpastes on swelling of mouse ear inflammation caused by xylene
As can be seen from table 1, the Baiyao toothpaste and the Yunnan white drug powder toothpaste have obvious inhibition effect on auricle inflammation swelling caused by xylene, and the Baiyao toothpaste group (inhibition rate 53.3%) is slightly superior to the Yunnan white drug powder toothpaste group (inhibition rate 51.1%), but the two have no significant difference; the Chinese herbal medicine decocted toothpaste has certain inhibition effect trend on auricle inflammation and swelling caused by dimethylbenzene, and the inhibition rate on the inflammation and swelling is 17.4 percent (P is more than 0.05).
1.2 Effect on carrageenan-induced foot swelling in rats
(1) The method comprises the following steps: the experiment was divided into 4 groups (10/group) each of which was: firstly, a model control group is given physiological saline; ② decocting toothpaste group with various Chinese herbal medicines; ③ Yunnan white-drug toothpaste group; and fourthly, a negative control group (a blank matrix group of the hundred-drug-decocting toothpaste).
After all rats were acclimatized for 3 days, the left hind paw volume of the rat was measured with a toe volume measuring instrument. Injecting 1% carrageenan physiological saline suspension 0.1 mL/one, smearing 0.7mL physiological saline or corresponding toothpaste and matrix 0.7g each, and wrapping left hind limb with adhesive plaster. After 3h, the applied substance was wiped off, and the volume of the left hind paw of the rat was measured again with a toe volume meter. And taking down the two circular lug pieces at the same positions of the two lug pieces by using a puncher with the diameter of 8mm, and precisely weighing the weight of the two circular lug pieces. The difference (mL) in the volume of the plantar area before and after inflammation was taken as the degree of swelling.
Inflammation inhibition (%) (results of [ (control swelling degree-administration swelling degree)/control swelling degree ] × 100% (2): see table 2.
TABLE 2 hundredInfluence of decoction toothpaste on rat foot swelling caused by carrageenan
As can be seen from table 2, the Baiyao toothpaste and the Yunnan white drug powder toothpaste have obvious inhibition effect on the swelling of feet caused by carrageenan, but the Baiyao toothpaste group (inhibition rate 43.3%) is slightly lower than the Yunnan white drug powder toothpaste group (inhibition rate 52.2%), but the two have no significant difference; the Chinese herbal medicine decocted toothpaste has certain inhibition effect trend on foot swelling caused by carrageenan, and the inhibition rate on inflammation swelling is 13.4% (P is more than 0.05).
2. The analgesic effect is as follows: influence on acetic acid induced writhing response of mice
(1) The method comprises the following steps: the experiment was divided into 4 groups (10/group) each of which was: firstly, a model control group is given physiological saline; ② decocting toothpaste group with various Chinese herbal medicines; ③ Yunnan white-drug toothpaste group; and fourthly, a negative control group (a blank matrix group of the hundred-drug-decocting toothpaste). After all mice were acclimatized for 3d, the abdomen was shaved (2 cm. times.2 cm). After 24 hours, respectively and uniformly smearing 0.4mL of physiological saline or 0.4g of corresponding toothpaste and matrix at the hair removal positions, wrapping the hair removal positions with gauze, keeping for 1 hour, and then cleaning the medicine with the physiological saline. The administration was continued for 3 d. 30 minutes after the last administration, 0.6% acetic acid solution (0.2 mL/mouse) was intraperitoneally injected, and the number of writhing reactions of the mice was immediately observed and the rate of decrease in the number of writhing reactions was calculated.
The rate of decrease in the number of writhing reaction (%) [ (number of writhing in control group-number of writhing in administration group)/number of writhing in control group ] × 100%.
(2) As a result: see table 3.
TABLE 3 influence of the herbal toothpastes on the acetic acid-induced writhing response in mice
As can be seen from table 3, the Baiyao toothpaste and the Yunnan Baiyao toothpaste have a certain inhibitory effect tendency on the writhing reaction of mice caused by acetic acid, but the Baiyao toothpaste group (reduction rate of 15.1%) and the Yunnan Baiyao toothpaste group (reduction rate of 13.0%) have no significant inhibitory effect on pain, and the two groups have no significant difference.
3. Hemostasis effect: influence on liver wound bleeding caused by mouse operation
(1) The method comprises the following steps: the experiment was divided into 4 groups (10/group) each of which was: firstly, a model control group is given physiological saline; ② decocting toothpaste group with various Chinese herbal medicines; ③ Yunnan white-drug toothpaste group; and fourthly, a negative control group (a blank matrix group of the hundred-drug-decocting toothpaste).
The experimental medicines (the Baiyao toothpaste, the Yunnan white powder toothpaste and the blank matrix of the Baiyao toothpaste) are prepared into 0.1g/mL liquid medicine by using normal saline, and the liquid medicine is prepared at present when the liquid medicine is used. After all animals were bred for 3 days, the mice were anesthetized with 8% chloral hydrate physiological saline solution (0.3mL/100g), the abdomen was disinfected with alcohol, the abdomen was cut open, the liver was exposed, an opening with a length of about 1.5cm and a depth of about 0.3cm was made on the surface of the liver with a scalpel, the above 3 kinds of medicinal solutions or physiological saline were uniformly applied, bleeding time of the wound was observed and recorded every 10 seconds, and the bleeding time reduction rate was calculated.
The bleeding time reduction rate (%) [ (control bleeding time-administration bleeding time)/control bleeding time ] × 100%.
(2) As a result: see table 4.
TABLE 4 Effect of the herbal toothpastes on bleeding time of the liver wound surface due to mouse surgery
As can be seen from table 4, the herbal toothpaste and the yunnan white herbal toothpaste both have significant effects of shortening the bleeding time of the operative wounds of the liver of the mouse, and the bleeding time reduction rates are respectively 30.0% (P <0.01) and 33.6% (P <0.01), but the two have no significant difference; the bleeding time of the liver surgical wound of the mouse with the toothpaste blank matrix is almost not shortened.
4. Promoting ulcer healing: influence on phenol-induced ulcer of oral mucosa of rat
(1) The method comprises the following steps: the experiment was divided into 9 groups (10/group) each of which was: firstly, a normal control group is not molded; model comparison group; ③ decocting 100 percent of toothpaste with various Chinese herbal medicines; fourthly, decocting 75 percent of toothpaste by using the Chinese herbal medicines; decocting the Chinese medicines with 50% of toothpaste group; sixthly, decocting the Chinese medicines to 25 percent of toothpaste group; seventhly, decocting 10 percent of toothpaste; eighty percent of Yunnan white drug powder toothpaste group; ninthly, negative control group (blank matrix group of the hundred-medicine decoction toothpaste). All animals were acclimatized for 3 d. Except for the normal control group, the rats were anesthetized with 8% chloral hydrate physiological saline solution (0.3ml/100g) by intraperitoneal injection. The mucous membrane of the median buccal cavity of the rat mouth is cauterized for 30min by using 95% phenol solution. After 24-48 h, the burned part is observed to have deep and large ulcer focus with the diameter of about 3-5 mm, and the rat is accompanied by the symptoms of reduced food intake and water intake, burnout, swollen lips and the like, namely the molding success is obtained. The rats successfully modeled were randomly divided into a model control group and each administration group. Uniformly smearing the burnt part with 0.1mL of physiological saline or Chinese traditional medicine decoction toothpaste, Yunnan white-drug powder toothpaste, and Chinese traditional medicine decoction toothpaste blank matrix respectively, once per day for 5 days. And (4) observing the recovery condition of the burned part every other day, taking a picture to record an ulcer picture and accurately calculating the area of the wound surface by using IPP software.
Ulcer healing rate (100%) [ (ulcer area on day-ulcer area on day)/ulcer area on day 0 ] × 100%.
(2) As a result, the
Influence on the rate of healing of oral ulcers in rats: see table 5.
TABLE 5 Effect of the herbal toothpastes on the healing Rate of phenol induced oral ulcers in rats
Note: p <0.05, P <0.01, compared to model control; the data in parentheses are the rates of change at each time point compared to the model control.
As can be seen from Table 5, after 1 day of administration, each administration group showed significant ulcer healing promoting effect compared with the model control group, except that the toothpaste group with 10% of the decoction of the Chinese herbal medicines showed significant ulcer healing promoting effect, the healing rates of the phenol-induced oral ulcer of the rats were not significantly different, and P was greater than 0.05. After 3 days of administration, compared with the model control group, the one-hundred-medicine-decoction 100% toothpaste group (P <0.05), the one-hundred-medicine-decoction 10% toothpaste group (P <0.01) and the Yunnan white-medicine toothpaste group (P <0.05) have significant difference on the healing rate of the phenol-induced rat dental ulcer. Except the group of the Chinese herbal medicine decoction toothpaste matrix, the other groups have the tendency of promoting the healing rate of the oral ulcer of the rat. After 5 days of administration, except the blank matrix group of the Chinese herbal medicine decoction toothpaste, compared with the model control group, the other administration groups have the tendency of promoting the increase of the healing rate of the phenol-induced rat dental ulcer; compared with the model control group, the toothpaste group with 100 percent of the Chinese herbal medicine decoction (P <0.01), the toothpaste group with 75 percent of the Chinese herbal medicine decoction (P <0.01), the toothpaste group with 10 percent of the Chinese herbal medicine decoction (P <0.01) and the toothpaste group with white drug in Yunnan province (P <0.05) have good effect of promoting ulcer healing, wherein the effect of promoting the ulcer healing of the Chinese herbal medicine decoction toothpaste group is better than that of the toothpaste group with white drug in Yunnan province.
5. And (3) preventing and treating dental caries: study on inhibitory action of cariogenic bacteria
The experimental strains (Streptococcus mutans Ingbrit, Streptococcus trichotomus 6715, Actinomyces viscosus ATCC19246) and the medium (BHI medium (broad heart infusion), light saliva agar medium (mitis-salivarus agar, MS), common blood agar medium).
Selecting neutral qualitative filter paper, beating into 6mm round pieces with a puncher, subpackaging in clean and dry glass plates, and sterilizing for 2h at 120 ℃ in dry heat for later use. Placing 80 pieces of paper in a small container, adding 1mL of medicinal liquid under aseptic condition, soaking in refrigerator overnight, placing in a freeze vacuum drier, and pumping to obtain paper containing 10% of Chinese gall leaven toothpaste, and sealing at below 4 deg.C for storage.
The strains were inoculated in 3ml LBHI medium at 95% N2、5％CO2Carrying out anaerobic culture at 37 ℃ for 18h, applying the Mai's turbidimetric standard, adjusting the concentration to 108CFU/mL, inoculating 50 μ L of the mixture into a 90mm plate, inoculating Streptococcus mutans Ingbbritt and Streptococcus tricholobus 6715 on MSB, inoculating actinomyces viscosus ATCC19246 on a common blood agar culture medium, uniformly coating the mixture by using a sterile triangular glass rod, clamping 10% of hundred-drug-decocted toothpaste paper by using a sterile forceps, placing the hundred-drug-decocted toothpaste paper on the surface of agar, and slightly pressing the paper to enable the paper to be in proper contact with the agar, wherein the intervals among the paper are equal. At 95% N2、5％CO2The cells were cultured at 37 ℃ for 48 hours, and the size of the zone of inhibition was measured with a vernier caliper, and the results are shown in Table 6.
TABLE 6 influence of decoction of herbs on the size of the zone of inhibition of cariogenic bacteria (mm)
As can be seen from Table 6, the herbal toothpaste has a good inhibitory effect on cariogenic bacteria.
In conclusion, the multi-herb decocted toothpaste can exert the effects of preventing and treating oral erosion, oral ulcer, inflammation and dental caries to the maximum extent, and has high stability of the effects; in vitro anti-inflammatory, analgesic and hemostatic experiments show that the multi-herb decocted toothpaste has obvious anti-inflammatory, analgesic and hemostatic effects; can quickly heal the dental ulcer; can play a good role in preventing and treating decayed teeth, and the effect is superior to that of Yunnan Baiyao toothpaste with high market acceptance; has fresh taste and excellent health care and treatment effects.
Claims (10)
1. A Chinese herbal medicine toothpaste is characterized in that: the composition is prepared from the following raw materials in parts by weight:
40-60 parts of a hundred-medicine decoction extract and 40-60 parts of a toothpaste matrix;
the decoction extract is an extract prepared by filtering and concentrating decoction water extract of the Chinese herbal medicines; the toothpaste matrix consists of the following auxiliary materials in percentage by mass:
45-55% of silicon dioxide, 10-13% of glycerol, 3-5% of xanthan gum, 1-3% of carboxymethyl cellulose, 1-3% of carbomer, 3-5% of sodium lauryl sulfate, 0.5-0.9% of calcium hydrophosphate, 0.5-1.5% of methyl hydroxybenzoate, 0.5-1.5% of saccharin sodium, 2-4% of peppermint oil, 2-4% of orange oil and the balance of water.
2. The toothpaste according to claim 1, wherein: the relative density of the Chinese gall decoction extract is 1.1-1.3.
3. The toothpaste according to claim 1, wherein: the toothpaste matrix consists of the following auxiliary materials in percentage by mass:
50% of silicon dioxide, 12% of glycerol, 4% of xanthan gum, 2% of carboxymethyl cellulose, 2% of carbomer, 4% of sodium lauryl sulfate, 0.7% of calcium hydrophosphate, 1% of methylparaben, 1% of saccharin sodium, 3% of peppermint oil, 3% of orange oil and the balance of water.
4. The toothpaste according to claim 1 to 3, wherein: the water is deionized water.
5. The toothpaste according to claim 1 to 3, wherein: the preparation method of the decoction of the hundred Chinese herbal medicines comprises the following steps:
decocting the Chinese herbal medicines with 7-10 times of water for 3 times, wherein each time lasts for 1.5-2.0 h, filtering, and concentrating the filtrate at 70 ℃ under reduced pressure until the relative density is 1.2 to obtain the Chinese herbal medicine.
6. A method of preparing a toothpaste according to claims 1 to 3 wherein: it comprises the following steps:
1) weighing the decoction extract and the toothpaste matrix according to the proportion;
2) mixing the raw materials in the step 1), and shearing and homogenizing to obtain the product.
7. The method of claim 6, wherein: the shearing homogenizing speed is 20000r/min, the pressure is 100MPa, and the cycle times are 8 times.
8. Use of the toothpaste of claims 1 to 3 for the preparation of a daily chemical for the prevention of oral erosion.
9. Use of a toothpaste according to claims 1 to 3 for the preparation of a daily chemical product for the prevention of mouth ulcers, oral inflammations and/or dental caries.
10. Use according to claim 9, characterized in that: the dental caries preventing is inhibiting Streptococcus mutans, Streptococcus cornu Cervi Pantotrichum, and/or Actinomyces viscosus.
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