CN110403891A - A kind of Chinese herbal toothpaste with oral health effect - Google Patents
A kind of Chinese herbal toothpaste with oral health effect Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of Chinese herbal toothpastes, it is using fermented Chinese gall herb and tea leaves extracting solution as active constituent, in addition the toothpaste that acceptable auxiliary material or complementary ingredient are prepared on chemical product；The fermented Chinese gall herb and tea leaves extracting solution is that fermented Chinese gall herb and tea leaves Aqueous extracts are filtered, the medicinal extract being prepared is concentrated.The effect of for effect ingredient origin of the invention in natural plants, the Chinese herbal medicine type used is few, does not chemically react, and can farthest play prevention and treatment oral cavity anabrosis, canker sore, inflammation, saprodontia；For gallic acid functional component therein in the toothpaste matrix of slant acidity, stable effect is high.
Description
Technical field
The invention belongs to daily use chemicals technical fields, and in particular to one kind has prevention oral cavity anabrosis, canker sore, caries efficacy
Anti-inflammatory hemostatic analgesia Chinese herbal toothpaste and its preparation process.
Background technique
With enriching for food variety, the disease incidence of saprodontia is being improved.The tooth of the chemical substances such as sodium fluoride, strontium fluoride is added
Cream is called toothpaste with fluoride, these fluorides can be enhanced the ability that tooth resists saprodontia, but can not blindly using and it is long-term
It uses.Some areas, fluorinated volume is excessively high in water, and water as people's long-term drinking will cause chronic fluorine poisoning.Tooth after poisoning
On there is the fluorine spot of yellow, can also suffer from fluorosis of bone, make one bow-backed.In these areas, people cannot reuse fluorine-containing certainly
Toothpaste.And the skill of gargling of brushing teeth of baby is not yet controlled completely, when children brush teeth inevitably can wrong the case where swallowing,
Children's toothpaste is required using low fluorine or floride-free formula.Therefore need to develop other anti-caries teeth cream.
Although canker sore does not influence the normal life of people, but also it is more to add many painful and worry, canker sore
Sleep that irregular, operating pressure is big, fatigue is nervous, depressed, particular about food, have no appetite, physically weak immunity difference etc. due to having a meal
Factor causes, and is a kind of mucous membrane of mouth office that can occur with the characteristics of any position of mucous membrane of mouth is by cyclical recurrent
Sex-limited ulcerative lesions.Canker sore also has the characteristics that recurrent, self limiting, or even can influence appetite, to the daily of people
Diet brings inconvenience.
The Chinese herbal medicine extract or its active constituent are added in toothpaste matrix, while meeting cleaning oral cavity demand,
The effect of making Chinese herbal toothpaste increase other preventions and health care, but there is presently no fermented Chinese gall herb and tea leaves are used for toothpaste, with prevention and treatment
The research of mouth disease, especially canker sore and saprodontia.
Summary of the invention
To solve the above problems, the present invention provides a kind of Chinese herbal toothpaste, it be with fermented Chinese gall herb and tea leaves extracting solution for activity at
Point, in addition the toothpaste that acceptable auxiliary material or complementary ingredient are prepared on chemical product；
The fermented Chinese gall herb and tea leaves extracting solution is that fermented Chinese gall herb and tea leaves Aqueous extracts are filtered, the medicinal extract being prepared is concentrated.
Further, it is made of the raw material of following weight parts:
40~60 parts of fermented Chinese gall herb and tea leaves extracting solution, 40~60 parts of lotion of toothpaste matrix.
Further, the relative density of the fermented Chinese gall herb and tea leaves extracting solution is 1.1-1.3.
Further, the lotion of toothpaste matrix is made of the auxiliary material of following mass percents:
Silica 45-55%, glycerol 10-13%, xanthan gum 3-5%, carboxymethyl cellulose 1-3%, carbomer 1-
3%, laruyl alcohol sodium sulfovinate 3-5%, calcium monohydrogen phosphate 0.5-0.9%, methyl hydroxybenzoate 0.5-1.5%, saccharin sodium 0.5-1.5%,
Peppermint oil 2-4%, orange oil 2-4%, surplus are water.Further, the lotion of toothpaste matrix is by following mass percents
Auxiliary material composition:
Silica 50%, glycerol 12%, xanthan gum 4%, carboxymethyl cellulose 2%, carbomer 2%, laruyl alcohol sulfuric acid
Ester sodium 4%, calcium monohydrogen phosphate 0.7%, methyl hydroxybenzoate 1%, saccharin sodium 1%, peppermint oil 3%, orange oil 3%, surplus are water.
Further, the water is deionized water.
The present invention also provides a kind of preparation methods of aforementioned fermented Chinese gall herb and tea leaves extracting solution, it includes the following steps:
Fermented Chinese gall herb and tea leaves medicinal material is taken, adds the water of 7~10 times of amounts to decoct 3 times, 1.5~2.0h, filtering, 70 DEG C of decompressions of filtrate are dense every time
Be reduced to relative density 1.2 to get.
The present invention also provides a kind of methods for preparing aforementioned toothpaste, it includes the following steps:
1) fermented Chinese gall herb and tea leaves extracting solution and lotion of toothpaste matrix are weighed according to the ratio；
2) take step 1) raw material mix, shear homogeneous to get.
Further, rate 20000r/min, the pressure 100MPa of the shearing homogeneous, cycle-index 8 times.
The present invention also provides a kind of application of aforementioned toothpaste in the chemical product that preparation has prevention oral cavity anabrosis.
The present invention also provides a kind of application of aforementioned toothpaste in the chemical product that preparation has prevention canker sore.
The present invention also provides a kind of application of aforementioned toothpaste in the chemical product that preparation has prevention oral inflammation.
The present invention finally provides a kind of application of aforementioned toothpaste in the chemical product that preparation has pre- anti-caries.
The effect of fermented Chinese gall herb and tea leaves toothpaste of the present invention, ingredient origin was in natural plants, and the Chinese herbal medicine type used is few, does not change
Reaction is learned, can farthest play prevention and treatment oral cavity anabrosis, the effect of canker sore, inflammation, saprodontia, gallic acid function therein
Ingredient is imitated in the toothpaste matrix of slant acidity, stable effect is high.
Through extracorporeal anti-inflammatory, analgesia, hemostasis experiment shows that anti-inflammatory Chinese herbal toothpaste of the invention, analgesia, haemostatic effect are aobvious
It writes；Can quickly be healed canker sore；Good preventive and therapeutic action, clean taste, health care and treatment can be played to saprodontia
Excellent effect.
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
Embodiment 1, fermented Chinese gall herb and tea leaves extracting solution of the present invention preparation
Fermented Chinese gall herb and tea leaves 10g is taken, adds 100ml water to decoct 3 times, each 2h, 70 DEG C of reduced pressure filtrate, obtains relative density after filtering
For 1.2 medicinal extract.
The preparation of embodiment 2, fermented Chinese gall herb and tea leaves extracting solution of the present invention
Fermented Chinese gall herb and tea leaves 10g is taken, adds 70ml water to decoct 3 times, each 1.5h, 70 DEG C of reduced pressure filtrate, obtains relatively close after filtering
The medicinal extract that degree is 1.2.
The preparation of embodiment 3, toothpaste of the present invention
Formula
Fermented Chinese gall herb and tea leaves extracting solution 50g, lotion of toothpaste matrix be 50g (lotion of toothpaste matrix composition are as follows: 50% silica,
12% glycerol, 4% xanthan gum, 2% carboxymethyl cellulose, 2% carbomer, 4% laruyl alcohol sodium sulfovinate, 0.7% calcium monohydrogen phosphate,
1% methyl hydroxybenzoate, 1% saccharin sodium, 3% peppermint oil, 3% orange oil, balance deionized water)
Preparation method:
1) fermented Chinese gall herb and tea leaves extracting solution and lotion of toothpaste matrix are weighed according to the ratio；
2) raw material mixes, shearing homogeneous (rate 20000r/min, pressure 100MPa, recycle 8 times) to get.
The preparation of embodiment 4, toothpaste of the present invention
Formula
Fermented Chinese gall herb and tea leaves extracting solution 40g, lotion of toothpaste matrix be 60g (lotion of toothpaste matrix composition are as follows: 50% silica,
12% glycerol, 4% xanthan gum, 2% carboxymethyl cellulose, 2% carbomer, 4% laruyl alcohol sodium sulfovinate, 0.7% calcium monohydrogen phosphate,
1% methyl hydroxybenzoate, 1% saccharin sodium, 3% peppermint oil, 3% orange oil, balance deionized water)
Preparation method:
1) fermented Chinese gall herb and tea leaves extracting solution and lotion of toothpaste matrix are weighed according to the ratio；
2) raw material mixes, shearing homogeneous (rate 20000r/min, pressure 100MPa, recycle 8 times) to get.
The preparation of embodiment 5, toothpaste of the present invention
Formula
Fermented Chinese gall herb and tea leaves extracting solution 60g, lotion of toothpaste matrix be 40g (lotion of toothpaste matrix composition are as follows: 50% silica,
12% glycerol, 4% xanthan gum, 2% carboxymethyl cellulose, 2% carbomer, 4% laruyl alcohol sodium sulfovinate, 0.7% calcium monohydrogen phosphate,
1% methyl hydroxybenzoate, 1% saccharin sodium, 3% peppermint oil, 3% orange oil, balance deionized water)
Preparation method:
1) fermented Chinese gall herb and tea leaves extracting solution and lotion of toothpaste matrix are weighed according to the ratio；
2) raw material mixes, shearing homogeneous (rate 20000r/min, pressure 100MPa, recycle 8 times) to get.
Illustrate beneficial effects of the present invention below by way of test example.
1 fermented Chinese gall herb and tea leaves toothpaste of test example and the comparative study of mica filled polypropylene effect
One, research purpose
Observation test toothpaste (toothpaste containing fermented Chinese gall herb and tea leaves extracting solution) and mica filled polypropylene are burst in anti-inflammatory, hemostasis, promotion
Effect contrast in terms of ulcer healing and prevention and treatment saprodontia.
Two, given the test agent
1. fermented Chinese gall herb and tea leaves toothpaste [100% toothpaste sample (toothpaste prepared by embodiment 3), (make 75% toothpaste sample by embodiment 3
Standby toothpaste is mixed with lotion of toothpaste matrix with 3:1), 50% toothpaste sample (embodiment 3 prepare toothpaste and lotion of toothpaste matrix
Mixed with 1:1), 25% toothpaste sample (embodiment 3 prepare toothpaste mixed with lotion of toothpaste matrix with 1:3), 10% toothpaste sample
Product (toothpaste prepared by embodiment 3 is mixed with lotion of toothpaste matrix with 1:9), wherein lotion of toothpaste matrix forms are as follows: 50% dioxy
SiClx, 12% glycerol, 4% xanthan gum, 2% carboxymethyl cellulose, 2% carbomer, 4% laruyl alcohol sodium sulfovinate, 0.7% phosphoric acid
Hydrogen calcium, 1% methyl hydroxybenzoate, 1% saccharin sodium, 3% peppermint oil, 3% orange oil, balance deionized water)；120g/ branch, by Chengdu Chinese medicine
Medicine university processes making in laboratory.
2. mica filled polypropylene (spearmint type), 180g/ branch, lot number: 20181229F19, by Yunnan Baiyao group share
Co., Ltd produces.
3. fermented Chinese gall herb and tea leaves toothpaste bare substrate, processes making in laboratory by Chengdu University of Traditional Chinese Medicine.
Three, research method and result
1. anti-inflammatory effect
The influence of 1.1 paraxylene induced mice auricle edemas
(1) method:
4 groups (10/group) of experiment point, be respectively: 1. model control group gives physiological saline；2. fermented Chinese gall herb and tea leaves toothpaste group；
3. mica filled polypropylene group；4. negative control group (fermented Chinese gall herb and tea leaves toothpaste bare substrate group).
After all mouse adaptive feeding 3d, 20 μ L dimethylbenzene is taken to be spread evenly across mouse right ear, in inflammation after 30min
Auris dextra is equably coated with 0.2g toothpaste, matrix or 0.2mL physiological saline, puts to death mouse after continuous action 1h, cuts left and right two
The ear on side.Two panels circle auricle is removed with the punch of diameter 8mm in the identical position of two ears, precision weighs two round auricles
Weight.The difference (mg) of left auricle weight is subtracted as inflammation swelling using auris dextra sheet weight.
Inflammation inhibiting rate (%)=[(control group swelling-administration group swelling)/control group swelling] × 100%.
(2) result: it is shown in Table 1.
The influence of 1 fermented Chinese gall herb and tea leaves toothpaste paraxylene induced mice auricle inflammation swelling of table
As shown in Table 1, the tool of auricle inflammation swelling caused by fermented Chinese gall herb and tea leaves toothpaste and mica filled polypropylene paraxylene is apparent
Inhibiting effect and fermented Chinese gall herb and tea leaves toothpaste group (inhibiting rate 53.3%) are slightly better than mica filled polypropylene group (inhibiting rate 51.1%), but the two
There was no significant difference；Auricle inflammation swelling caused by fermented Chinese gall herb and tea leaves toothpaste paraxylene has certain inhibiting effect trend, to inflammation
Disease swelling inhibiting rate 17.4% (P > 0.05).
The influence of 1.2 Carrageenans cause rat paw edema
(1) method: 4 groups (10/group) of experiment point, be respectively: 1. model control group gives physiological saline；2. hundred medicines
Decoct toothpaste group；3. mica filled polypropylene group；4. negative control group (fermented Chinese gall herb and tea leaves toothpaste bare substrate group).
After all rat adaptive feeding 3d, with the left back sufficient volume of toes capacity measurer measurement rat.Only by 0.1mL/
1% carrageenan normal saline suspension is injected after rat left hind vola pedis is subcutaneous, uniformly smears 0.7mL physiological saline or phase
Each 0.7g of toothpaste and matrix answered, then left hind is wrapped up with adhesive plaster.Applied substance is put on the skin only after continuous action 3h, uses toes again
Capacity measurer measures the left back vola pedis volume of rat.Two panels circle is removed with the punch of diameter 8mm in the identical position of two ears
Auricle, precision weigh two round auricle weight.Cause the vola pedis volume difference (mL) of scorching front and back as inflammation swelling using it.
Inflammation inhibiting rate (%)=[(control group swelling-administration group swelling)/control group swelling] × 100% (2)
As a result: being shown in Table 2.
The influence of 2 fermented Chinese gall herb and tea leaves toothpaste Carrageenan of table cause rat paw edema
As shown in Table 2, the tool of foot swelling caused by fermented Chinese gall herb and tea leaves toothpaste and mica filled polypropylene Carrageenan is apparent inhibits
It acts on but fermented Chinese gall herb and tea leaves toothpaste group (inhibiting rate 43.3%) is slightly below mica filled polypropylene group (inhibiting rate 52.2%), but the two is without aobvious
Write sex differernce；Foot swelling caused by fermented Chinese gall herb and tea leaves toothpaste Carrageenan has certain inhibiting effect trend, presses down to inflammation swelling
Rate 13.4% (P > 0.05) processed.
2. analgesic activity: Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction
(1) method: 4 groups (10/group) of experiment point, be respectively: 1. model control group gives physiological saline；2. hundred medicines
Decoct toothpaste group；3. mica filled polypropylene group；4. negative control group (fermented Chinese gall herb and tea leaves toothpaste bare substrate group).All mouse adaptability are raised
After supporting 3d, belly shaving (2cm × 2cm).0.4mL physiological saline or corresponding is equably smeared at hair respectively at picking after 24 hours
Toothpaste and each 0.4g of matrix, then picked at hair with gauze package covering, with physiological saline clean up drug after keeping 1h.Continuously
3d is administered.0.6% acetum (0.2mL/ is only) is injected intraperitoneally after last dose 30 minutes, the writhing for observing mouse immediately is anti-
It answers number and calculates writhing response number reduced rate.
Writhing response number reduced rate (%)=[(control group writhing number-administration group writhing number)/control group writhing
Number] × 100%.
(2) 3 result: are shown in Table.
3 fermented Chinese gall herb and tea leaves toothpaste Dichlorodiphenyl Acetate of table causes the influence of mouse writhing reaction
As shown in Table 3, the reaction of mouse writhing caused by fermented Chinese gall herb and tea leaves toothpaste and mica filled polypropylene Dichlorodiphenyl Acetate tool is bright certain
Inhibiting effect trend, but fermented Chinese gall herb and tea leaves toothpaste group (reduced rate 15.1%) and mica filled polypropylene group (reduced rate 13.0%) are without aobvious
The inhibition of pain of work acts on, and there was no significant difference for the two.
3. anastalsis: performing the operation to mouse and cause the influence of liver surface of a wound bleeding
(1) method: 4 groups (10/group) of experiment point, be respectively: 1. model control group gives physiological saline；2. hundred medicines
Decoct toothpaste group；3. mica filled polypropylene group；4. negative control group (fermented Chinese gall herb and tea leaves toothpaste bare substrate group).
Experimental drug (fermented Chinese gall herb and tea leaves toothpaste, mica filled polypropylene and fermented Chinese gall herb and tea leaves toothpaste bare substrate) is used into normal saline
At the medical fluid of 0.1g/mL, matching while using.It is after all Animal adaptability raising 3d, mouse is water-soluble with 8% chloraldurate physiology salt
After (0.3mL/100g) anesthesia, with alcohol to abdominal cut after abdomen disinfection, exposure liver is standardized in liver surface with scalpel
Block is about 1.5cm, and the opening of deep about 0.3cm is uniformly smeared above-mentioned 3 kinds of medical fluids or physiological saline respectively, observed every 10 seconds
And record bleeding time and the bleeding time of calculating reduced rate of wound.
Bleeding time reduced rate (%)=[(control group bleeding time-administration group the bleeding time)/control group bleeding time]
× 100%.
(2) 4 result: are shown in Table.
4 fermented Chinese gall herb and tea leaves toothpaste of table, which performs the operation to mouse, causes the influence in liver surface of a wound bleeding time
As shown in Table 4, fermented Chinese gall herb and tea leaves toothpaste and mica filled polypropylene all have the mouse liver surgical wound bleeding time
Significant shortening effect, bleeding time reduced rate are respectively 30.0% (P < 0.01), 33.6% (P < 0.01), but the two is without significant
Sex differernce；The toothpaste bare substrate mouse liver surgical wound bleeding time acts on almost without shortening.
4. promoting ulcer healing effect: the influence of Pyrogentisinic Acid's cause rat stomatocace
(1) method: 9 groups (10/group) of experiment point are respectively: 1. Normal group, without modeling；2. model pair
According to group；3. 100% toothpaste group of fermented Chinese gall herb and tea leaves；4. 75% toothpaste group of fermented Chinese gall herb and tea leaves；5. 50% toothpaste group of fermented Chinese gall herb and tea leaves；6. 25% tooth of fermented Chinese gall herb and tea leaves
Cream group；7. 10% toothpaste group of fermented Chinese gall herb and tea leaves；8. mica filled polypropylene group；9. negative control group (fermented Chinese gall herb and tea leaves toothpaste bare substrate group).
All Animal adaptabilities raise 3d.In addition to Normal group, 8% chloraldurate normal saline solution is injected intraperitoneally in remaining each group
(0.3ml/100g) anesthetized rat.Rat oral cavity center cheek mucous membrane 30min is burnt with 95% phenol solution.It is observed after 24~48h
It was found that being cauterized that position occurs deep and big ulcer lesion, diameter are about 3~5mm, while rat subtracts with food ration amount of drinking water
Less, the success of the symptoms such as burnout, lip swelling, as modeling.The successful rat of modeling is randomly divided into model control group and each
Administration group.It is each with the fermented Chinese gall herb and tea leaves toothpaste of physiological saline or various concentration, mica filled polypropylene, fermented Chinese gall herb and tea leaves toothpaste bare substrate
0.1mL is uniformly smeared and is cauterized position, once a day, continues 5d.Every other day observation is cauterized the recovery situation at position, takes pictures
Record ulcer picture and the area that the surface of a wound is accurately calculated using IPP software.
Ulcer healing rate (100%)=[(0 day ulcer area-same day ulcer area)/0 day ulcer area] ×
100%.
(2) result
1. the influence to rat canker sore healing rate: being shown in Table 5.
The influence of 5 fermented Chinese gall herb and tea leaves toothpaste Pyrogentisinic Acid of table cause rat canker sore healing rate
Note: compared with model control group, P < 0.01 * P < 0.05, * *；Data in bracket be each time point respectively with model
The change rate that control group compares.
As shown in Table 5, after being administered 1 day, each administration group is compared with model control group, in addition to 10% toothpaste group of fermented Chinese gall herb and tea leaves is shown
Outside the effect for significantly promoting ulcer healing out, remaining each group Pyrogentisinic Acid causes the healing rate of rat canker sore, and that there are no significant is poor
It is different, P is equal > and 0.05.After administration 3 days, each administration group is compared with model control group, 100% toothpaste group (P < 0.05) of fermented Chinese gall herb and tea leaves, hundred medicines
It is aobvious that pan-fried 10% toothpaste group (P < 0.01) and mica filled polypropylene group (P < 0.05) Pyrogentisinic Acid cause the healing rate of rat canker sore to have
Write sex differernce.In addition to fermented Chinese gall herb and tea leaves toothpaste matrix group, remaining each group has the tendency that promoting the healing rate of rat canker sore.Administration 5
After it, in addition to fermented Chinese gall herb and tea leaves toothpaste bare substrate group, compared with model control group, remaining each administration group Pyrogentisinic Acid causes rat oral cavity to burst
The healing rate of ulcer, which has, promotes increased trend；Each administration group compared with model control group, 100% toothpaste group of fermented Chinese gall herb and tea leaves (P <
0.01), 75% toothpaste group (P < 0.01) of fermented Chinese gall herb and tea leaves, 10% toothpaste group (P < 0.01) of fermented Chinese gall herb and tea leaves and mica filled polypropylene group (P <
0.05) the good effect for promoting ulcer healing is shown, the effect that wherein fermented Chinese gall herb and tea leaves toothpaste group promotees ulcer healing is better than Yunnan
Baiyao toothpaste group.
5. preventing and treating saprodontia: the inhibiting effect research to cariogenic bacteria
Experimental strain (streptococcus mutans Ingbritt, streptococcus sobrinus 6715, actinomyces viscosus ATCC19246) and culture
Base is (BHI culture medium (brain heart infusion), light saliva agar medium (mitis-salivarus agar, MS), general
Logical blood agar culture-medium).
The property chosen qualitative filter paper is sub-packed in the glass dish of clean dried with the disk that puncher breaks into 6mm, xeothermic
120 DEG C of sterilizing 2h are spare.80 scraps of paper are put in a small container, medical fluid 1mL is added under sterile working, sets in refrigerator and impregnated
Night is subsequently placed in and is drained in frozen vacuum dryer up to the scraps of paper of 10% fermented Chinese gall herb and tea leaves toothpaste are contained, and 4 DEG C or less are sealed.
Strain is inoculated in 3mLBHI liquid, 95%N2, 5%CO2, 37 DEG C of Anaerobic culturel 18h adjust using Maxwell than turbid standard
Saving its concentration is 108CFU/mL, takes 50 μ L to be inoculated in 90mm plate, streptococcus mutans Ingbritt, streptococcus sobrinus 6715
It is inoculated on MSB, actinomyces viscosus ATCC19246 is inoculated on common blood agar culture-medium, is smoothened with sterile triangle glass rod, so
The 10% fermented Chinese gall herb and tea leaves toothpaste scraps of paper are clamped with aseptic nipper afterwards and are placed on agar surface, and light paper-pressing sheet contacts it suitably with agar, respectively
Spacing is equal between the scraps of paper.In 95%N2, 5%CO2, cultivate 48h at 37 DEG C, the inhibition zone size of each scraps of paper is surveyed with vernier caliper, is tied
Fruit is shown in Table 6.
Influence (mm) of the 6 fermented Chinese gall herb and tea leaves toothpaste of table to cariogenic bacteria inhibition zone size
As can be seen from Table 6, fermented Chinese gall herb and tea leaves toothpaste has good inhibiting effect to cariogenic bacteria.
To sum up, fermented Chinese gall herb and tea leaves toothpaste of the present invention can farthest play prevention and treatment oral cavity anabrosis, canker sore, inflammation, saprodontia
The effect of, and stable effect is high；Through extracorporeal anti-inflammatory, analgesia, hemostasis experiment show fermented Chinese gall herb and tea leaves toothpaste of the present invention it is anti-inflammatory, analgesia,
Haemostatic effect is significant；Can quickly be healed canker sore；Good preventive and therapeutic action can be played to saprodontia, and effect is better than city
The high hundred medicine toothpaste of Yunnan of field acceptance；Clean taste, health care and therapeutic effect are excellent.
Claims (12)
1. a kind of Chinese herbal toothpaste, it is characterised in that: it is using fermented Chinese gall herb and tea leaves extracting solution as active constituent, in addition can connect on chemical product
The toothpaste that the auxiliary material or complementary ingredient received are prepared；
The fermented Chinese gall herb and tea leaves extracting solution is that fermented Chinese gall herb and tea leaves Aqueous extracts are filtered, the medicinal extract being prepared is concentrated.
2. toothpaste according to claim 1, it is characterised in that: it is made of the raw material of following weight parts:
40~60 parts of fermented Chinese gall herb and tea leaves extracting solution, 40~60 parts of lotion of toothpaste matrix.
3. toothpaste according to claim 1 or 2, it is characterised in that: the relative density of the fermented Chinese gall herb and tea leaves extracting solution is 1.1-
1.3。
4. toothpaste according to claim 2, it is characterised in that: the lotion of toothpaste matrix is by following mass percents
Auxiliary material composition:
Silica 45-55%, glycerol 10-13%, xanthan gum 3-5%, carboxymethyl cellulose 1-3%, carbomer 1-3%, the moon
Cinnamic alcohol sodium sulfovinate 3-5%, calcium monohydrogen phosphate 0.5-0.9%, methyl hydroxybenzoate 0.5-1.5%, saccharin sodium 0.5-1.5%, peppermint oil
2-4%, orange oil 2-4%, surplus are water.
5. toothpaste according to claim 4, it is characterised in that: the lotion of toothpaste matrix is by following mass percents
Auxiliary material composition:
Silica 50%, glycerol 12%, xanthan gum 4%, carboxymethyl cellulose 2%, carbomer 2%, laruyl alcohol sodium sulfovinate
4%, calcium monohydrogen phosphate 0.7%, methyl hydroxybenzoate 1%, saccharin sodium 1%, peppermint oil 3%, orange oil 3%, surplus is water.
6. toothpaste according to claim 4 or 5, it is characterised in that: the water is deionized water.
7. the preparation method of fermented Chinese gall herb and tea leaves extracting solution described in a kind of claims 1 to 3, it is characterised in that: it includes the following steps:
Fermented Chinese gall herb and tea leaves medicinal material is taken, adds the water of 7~10 times of amounts to decoct 3 times, 1.5~2.0h, is filtered, 70 DEG C of filtrate are concentrated under reduced pressure into every time
Relative density 1.2 to get.
8. a kind of method for preparing claim 1~6 toothpaste, it is characterised in that: it includes the following steps:
1) fermented Chinese gall herb and tea leaves extracting solution and lotion of toothpaste matrix are weighed according to the ratio；
2) take step 1) raw material mix, shear homogeneous to get.
9. preparation method according to claim 8, it is characterised in that: the rate 20000r/min of the shearing homogeneous, pressure
Strong 100MPa, cycle-index 8 times.
10. application of the toothpaste described in Claims 1 to 4 in the chemical product that preparation has prevention oral cavity anabrosis.
11. toothpaste described in Claims 1 to 4 is in the chemical product that preparation has prevention canker sore, oral inflammation and/or saprodontia
Application.
12. application according to claim 11, it is characterised in that: the pre- anti-caries are to inhibit streptococcus mutans, fine hair
Streptococcus and/or actinomyces viscosus.
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| CN112717030A (en) * | 2021-01-26 | 2021-04-30 | 成都中医药大学附属医院 | Pharmaceutical composition for preventing and treating oral diseases and preparation method and application thereof |
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