CN109224037A - A kind of antibacterial cream of erysipelas and preparation method thereof - Google Patents
A kind of antibacterial cream of erysipelas and preparation method thereof Download PDFInfo
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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Abstract
The invention discloses a kind of antibacterial cream of erysipelas, belong to field of medicine preparing technology, the antibacterial cream fungistatic effect for solving the prior art is unobvious, it is difficult to the problem of effectively being treated to common fungal infection or bacterium infection, is characterized in that: including following raw material: Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric, the coptis, oil, beeswax and vaseline；The antibacterial cream of erysipelas of the invention has cool blood, anti-inflammatory, the effect promoted the production of body fluid；Promoting blood circulation, adjusts the effect of immunity of organisms；Promoting the circulation of qi is invigorated blood circulation, analgesic, the effect of promoting menstruation；Detoxify, reduce swelling, going negative effect；Purging intense heat detoxifies, quenches one's thirst, the effect of eliminating dampness；After smearing, inhibition bacterial growth can be played in the case where reducing skin injury；Capillary of skin can be expanded, promotes skin blood circulation, increases skin-nourishing, adjust the water and oil balance of skin, skin elasticity can be enhanced, it is natural without side-effects, it is easy to use, and effect is more preferable.
Description
Technical field
The present invention relates to field of medicine preparing technology, specifically a kind of antibacterial cream of erysipelas and preparation method thereof.
Background technique
Skin causes a more damp and hotter environment due to hidrosis, humidity, mentions for the growth and breeding of many microorganisms
Good condition is supplied.Ulcer, inflammation and damage etc. can all cause skin infection and cutaneous lesions and lead to skin disease, wherein skin
Skin disease caused by skin infects is more common.Skin infection is mainly caused by bacterium or fungi, such as staphylococcus aureus, big
Enterobacteria and Candida albicans etc..Therefore, it is generally used in dermopathic clinical treatment caused by skin infection and sterilizes, is antibacterial
Treatment method.
Existing Western medicine bacteriostatic has irritation effect, is not suitable for sensitive.Therefore, it is necessary to a kind of Chinese medicine sterilizings
Antibacterial cream of the erysipelas of ingredient and preparation method thereof, so that the antibacterial cream of the erysipelas of preparation reduces the irritation of bacteriostatic, naturally without pair
Effect, preferably treats skin infection and skin disease.
Summary of the invention
The purpose of the present invention is to provide antibacterial cream of a kind of erysipelas and preparation method thereof, to solve to mention in above-mentioned background technique
Out the problem of.
To achieve the above object, the invention provides the following technical scheme:
A kind of antibacterial cream of erysipelas, including below according to the raw material of parts by weight: 160-200 parts of Radix Angelicae Sinensis, 50-70 parts of Cortex Phellodendri,
160-200 parts yellow, 140-180 parts of turmeric, 50-70 parts of the coptis, 1800-2200 parts of oil, 1000-1300 parts of beeswax, vaseline
180-220 parts.
As a further solution of the present invention: including below according to the raw material of parts by weight: 170-190 parts of Radix Angelicae Sinensis, Cortex Phellodendri 55-
65 parts, it is 170-190 parts of glutinous rehmannia, 150-170 parts of turmeric, 55-65 parts of the coptis, 1900-2100 parts of oil, 1100-1200 parts of beeswax, all
190-210 parts of intellectual circle.
As the present invention further scheme: including below according to the raw material of parts by weight: 180 parts of Radix Angelicae Sinensis, 60 parts of Cortex Phellodendri,
180 parts of glutinous rehmannia, 160 parts of turmeric, 60 parts of the coptis, oily 2000 parts, 1150 parts of beeswax, 200 parts of vaseline.
In above-mentioned Chinese medicine composition of the invention, selected raw material effect and effect are as follows:
1) glutinous rehmannia: cool in nature, sweet-bitter flavor；With enriching yin and nourishing kidney, the effect of blood-nourishing is enriched blood, cool blood；All deficiency of Yin deficiency of blood kidney deficiency persons
It is eaten, it is quite helpful；In addition, glutinous rehmannia plays the role of heart tonifying diuresis, antipyretic anti-inflammatory, promotes blood clotting and reduces blood glucose；Matching
Side the inside has cool blood, anti-inflammatory, the effect promoted the production of body fluid.
2) Radix Angelicae Sinensis: sweet in flavor to invigorate blood circulation with enriching blood, menstruction regulating and pain relieving can cure mainly all diseases of the deficiency of blood；There is promoting blood circulation in formula, adjust
The effect of immunity of organisms.
3) turmeric: acrid flavour, bitter, warm-natured, promoting blood circulation and stopping pain, stagnation resolvation, promoting the circulation of qi, promoting menstruation, wind-dispelling；There is promoting the circulation of qi in formula, it is living
Blood, analgesic, the effect of promoting menstruation.
4) Cortex Phellodendri: bitter is trembled with fear；Effect: heat-clearing, eliminating dampness, purging intense heat, removing toxic substances；The major functions: damp-heat dysentery, diarrhea, jaundice, nocturnal emission,
Stranguria with turbid discharge, leukorrhagia, hectic fever due to yin labor heat, night sweat, aphthae, red eye, swell pain, skin sore, skin eczema；There is solution in recipe
Poison, the effect reduced swelling, remove yin.
5) coptis: bitter is trembled with fear；Effect: heat-clearing and damp-drying drug, purging fire for removing toxin are used for damp and hot feeling of fullness, vomit acid regurgitation, and dysentery is yellow
Subcutaneous ulcer, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst；There is purging intense heat, solution in recipe
Poison is quenched one's thirst, the effect of eliminating dampness.
As further scheme of the invention: Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric, the coptis are all that medicine materical crude slice is used as medicine.
Based on the preparation method of the antibacterial cream of the erysipelas, steps are as follows:
1) Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric and the medicine materical crude slice of the coptis are taken by weight, adds the water of 5~7 times of weight, impregnate 30 points
Then clock decocts 50~70 minutes, filter to get filtrate A and the dregs of a decoction；
2) water for adding 3~5 times of weight in the dregs of a decoction again, decocts 30~50 minutes, and filter to get filtrate B,
3) merge filtrate A and liquor B twice, be concentrated under reduced pressure, freeze-drying obtains powdered extract；
4) above-mentioned powdered extract is poured into blender, and oil, beeswax and vaseline is added, stirred in blender
Uniformly, the antibacterial cream of erysipelas can be obtained.
As further scheme of the invention: in step 4), agitator speed is to carry out under the conditions of 120~250r/min
Stir 15min.
The antibacterial cream of the erysipelas is preparing the antibacterial of skin and/or analgesic and/or promoting blood circulation and/or removing toxic substances and/or detumescence
And/or the purposes in the drug of anti-inflammatory.
Compared with prior art, the beneficial effects of the present invention are:
Using the antibacterial cream of erysipelas prepared by method of the invention, there is cool blood, anti-inflammatory, the effect promoted the production of body fluid；Promoting blood circulation is adjusted
The effect of immunity of organisms；Promoting the circulation of qi is invigorated blood circulation, analgesic, the effect of promoting menstruation；Detoxify, reduce swelling, going negative effect；Purging intense heat detoxifies, disappears
Yearningly, the effect of eliminating dampness；After smearing, inhibition bacterial growth can be played in the case where reducing skin injury；Skin capillary can be expanded
Blood vessel promotes skin blood circulation, increases skin-nourishing, adjust the water and oil balance of skin, can enhance skin elasticity, naturally without pair
Effect, it is easy to use, and effect is more preferable.
Specific embodiment
Technical solution of the present invention is described in more detail With reference to embodiment.
Embodiment 1
A kind of antibacterial cream of erysipelas, including below according to the raw material of parts by weight: 160 parts of Radix Angelicae Sinensis, 50 parts of Cortex Phellodendri, 160 parts of glutinous rehmannia,
140 parts of turmeric, 50 parts of the coptis, oily 1800 parts, 1000 parts of beeswax, 180 parts of vaseline.
Further, Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric, the coptis are all that medicine materical crude slice is used as medicine.
Based on the preparation method of the antibacterial cream of the erysipelas, steps are as follows:
1) Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric and the medicine materical crude slice of the coptis are taken by weight, adds the water of 5 times of weight, are impregnated 30 minutes,
Then it decocts 50 minutes, filter to get filtrate A and the dregs of a decoction；
2) water for adding 3 times of weight in the dregs of a decoction again, decocts 30 minutes, and filter to get filtrate B,
3) merge filtrate A and liquor B twice, be concentrated under reduced pressure, freeze-drying obtains powdered extract；
4) above-mentioned powdered extract is poured into blender, and oil, beeswax and vaseline is added, stirred in blender
Uniformly, the antibacterial cream of erysipelas can be obtained.
As further scheme of the invention: in step 4), agitator speed is to be stirred under the conditions of 120r/min
15min。
Embodiment 2
A kind of antibacterial cream of erysipelas, including below according to the raw material of parts by weight: 170 parts of Radix Angelicae Sinensis, 55 parts of Cortex Phellodendri, 170 parts of glutinous rehmannia,
150 parts of turmeric, 55 parts of the coptis, oily 1900 parts, 1100 parts of beeswax, 190 parts of vaseline.
Further, Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric, the coptis are all that medicine materical crude slice is used as medicine.
Based on the preparation method of the antibacterial cream of the erysipelas, steps are as follows:
1) Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric and the medicine materical crude slice of the coptis are taken by weight, adds the water of 7 times of weight, are impregnated 30 minutes,
Then it decocts 70 minutes, filter to get filtrate A and the dregs of a decoction；
2) water for adding 5 times of weight in the dregs of a decoction again, decocts 50 minutes, and filter to get filtrate B,
3) merge filtrate A and liquor B twice, be concentrated under reduced pressure, freeze-drying obtains powdered extract；
4) above-mentioned powdered extract is poured into blender, and oil, beeswax and vaseline is added, stirred in blender
Uniformly, the antibacterial cream of erysipelas can be obtained.
As further scheme of the invention: in step 4), agitator speed is to be stirred under the conditions of 250r/min
15min。
Embodiment 3
A kind of antibacterial cream of erysipelas, including below according to the raw material of parts by weight: 180 parts of Radix Angelicae Sinensis, 60 parts of Cortex Phellodendri, 180 parts of glutinous rehmannia,
160 parts of turmeric, 60 parts of the coptis, oily 2000 parts, 1150 parts of beeswax, 200 parts of vaseline.
Further, Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric, the coptis are all that medicine materical crude slice is used as medicine.
Based on the preparation method of the antibacterial cream of the erysipelas, steps are as follows:
1) Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric and the medicine materical crude slice of the coptis are taken by weight, adds the water of 6 times of weight, are impregnated 30 minutes,
Then it decocts 60 minutes, filter to get filtrate A and the dregs of a decoction；
2) water for adding 4 times of weight in the dregs of a decoction again, decocts 40 minutes, and filter to get filtrate B,
3) merge filtrate A and liquor B twice, be concentrated under reduced pressure, freeze-drying obtains powdered extract；
4) above-mentioned powdered extract is poured into blender, and oil, beeswax and vaseline is added, stirred in blender
Uniformly, the antibacterial cream of erysipelas can be obtained.
As further scheme of the invention: in step 4), agitator speed is to be stirred under the conditions of 180r/min
15min。
Embodiment 4
A kind of antibacterial cream of erysipelas, including below according to the raw material of parts by weight: 190 parts of Radix Angelicae Sinensis, 65 parts of Cortex Phellodendri, 190 parts of glutinous rehmannia,
170 parts of turmeric, 65 parts of the coptis, oily 2100 parts, 1200 parts of beeswax, 210 parts of vaseline.
Further, Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric, the coptis are all that medicine materical crude slice is used as medicine.
Based on the preparation method of the antibacterial cream of the erysipelas, steps are as follows:
1) Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric and the medicine materical crude slice of the coptis are taken by weight, adds the water of 7 times of weight, are impregnated 30 minutes,
Then it decocts 70 minutes, filter to get filtrate A and the dregs of a decoction；
2) water for adding 5 times of weight in the dregs of a decoction again, decocts 50 minutes, and filter to get filtrate B,
3) merge filtrate A and liquor B twice, be concentrated under reduced pressure, freeze-drying obtains powdered extract；
4) above-mentioned powdered extract is poured into blender, and oil, beeswax and vaseline is added, stirred in blender
Uniformly, the antibacterial cream of erysipelas can be obtained.
As further scheme of the invention: in step 4), agitator speed is to be stirred under the conditions of 250r/min
15min。
Embodiment 5
A kind of antibacterial cream of erysipelas, including below according to the raw material of parts by weight: 200 parts of Radix Angelicae Sinensis, 70 parts of Cortex Phellodendri, 200 parts of glutinous rehmannia,
180 parts of turmeric, 70 parts of the coptis, oily 2200 parts, 1300 parts of beeswax, 220 parts of vaseline.
Further, Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric, the coptis are all that medicine materical crude slice is used as medicine.
Based on the preparation method of the antibacterial cream of the erysipelas, steps are as follows:
1) Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric and the medicine materical crude slice of the coptis are taken by weight, adds the water of 5 times of weight, are impregnated 30 minutes,
Then it decocts 50 minutes, filter to get filtrate A and the dregs of a decoction；
2) water for adding 3 times of weight in the dregs of a decoction again, decocts 30 minutes, and filter to get filtrate B,
3) merge filtrate A and liquor B twice, be concentrated under reduced pressure, freeze-drying obtains powdered extract；
4) above-mentioned powdered extract is poured into blender, and oil, beeswax and vaseline is added, stirred in blender
Uniformly, the antibacterial cream of erysipelas can be obtained.
As further scheme of the invention: in step 4), agitator speed is to be stirred under the conditions of 120r/min
15min。
The antibacterial cream of the erysipelas that the embodiment of the present invention 1 is prepared to embodiment 5, by function assessment test come system evaluation
Its effect.
1, the fungistatic effect of the antibacterial cream of erysipelas
Test method: the antibacterial cream of erysipelas and 1 group of commercially available suppression that 100g embodiment 1 is prepared to embodiment 5 are weighed respectively
Bacterium cream as a control group, and carries out adding bacterium operation (including staphylococcus aureus, Escherichia coli and Candida albicans), adds each thin
Bacterium amount is 1 × (107~108), is adding the bacteria containing amount in the after bacterium the 0th day, the 5th day and the 10th day sampling analysis sample.
Evaluation method: survival bacterium is greater than 0.1%, and sample does not pass through test.
Test result: concrete outcome is as shown in table 1 below.
From result above as can be seen that table 1 statistics indicate that the antibacterial cream of erysipelas of the invention, there is good antibacterial effect
Fruit after smearing, can play inhibition bacterial growth in the case where reducing skin injury；Capillary of skin can be expanded, skin is promoted
Skin blood circulation increases skin-nourishing, adjusts the water and oil balance of skin, can enhance skin elasticity, natural without side-effects, user
Just, and effect is more preferable.
2, toxicity test
Selecting weight is small white mouse 20 of 20 ± 3g, and half male and half female is divided into 5 groups, every group of male and female each 2.By each small white mouse
Back shaving, every shaving area are 2cm × 3cm, then smear what embodiment 1- embodiment 5 was prepared in back shaving area
The antibacterial cream of erysipelas, applying dose is about 3.0g/, continuous coating 30 days.When during coating and 1 week after being discontinued, observation white mouse growth
State and activity and diet, identification hematology, blood biochemical analysis, organ tissue structure and routine urinalysis etc..
As a result, it has been found that the health existence of all small white mouses, without any side effects；Blood picture, liver function, each dirty is dissected and observed
Device structural state, the indifference compared with normal small white mouse.
It is demonstrated experimentally that the antibacterial cream of erysipelas provided by the invention has no toxic side effect, can use safely.
Better embodiment of the invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be without departing from the purpose of the present invention
It makes a variety of changes.
Claims (7)
1. a kind of antibacterial cream of erysipelas, which is characterized in that including below according to the raw material of parts by weight: 160-200 parts of Radix Angelicae Sinensis, Cortex Phellodendri
50-70 parts, 160-200 parts of glutinous rehmannia, 140-180 parts of turmeric, 50-70 parts of the coptis, 1800-2200 parts of oil, beeswax 1000-1300
Part, 180-220 parts of vaseline.
2. the antibacterial cream of erysipelas according to claim 1, which is characterized in that including below according to the raw material of parts by weight: Radix Angelicae Sinensis
170-190 parts, 55-65 parts of Cortex Phellodendri, 170-190 parts of glutinous rehmannia, 150-170 parts of turmeric, 55-65 parts of the coptis, 1900-2100 parts of oil,
1100-1200 parts of beeswax, 190-210 parts of vaseline.
3. the antibacterial cream of erysipelas according to claim 2, which is characterized in that including below according to the raw material of parts by weight: Radix Angelicae Sinensis
180 parts, 60 parts of Cortex Phellodendri, 180 parts of glutinous rehmannia, 160 parts of turmeric, 60 parts of the coptis, oily 2000 parts, 1150 parts of beeswax, 200 parts of vaseline.
4. the antibacterial cream of erysipelas according to claim 3, which is characterized in that Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric, the coptis are drink
Piece is used as medicine.
5. a kind of preparation method of the antibacterial cream of erysipelas as described in claim 1-4 is any, which is characterized in that steps are as follows:
1) Radix Angelicae Sinensis, Cortex Phellodendri, glutinous rehmannia, turmeric and the medicine materical crude slice of the coptis are taken by weight, adds the water of 5~7 times of weight, are impregnated 30 minutes,
Then it decocts 50~70 minutes, filter to get filtrate A and the dregs of a decoction；
2) water for adding 3~5 times of weight in the dregs of a decoction again, decocts 30~50 minutes, filter to get filtrate B；
3) merge filtrate A and liquor B twice, be concentrated under reduced pressure, freeze-drying obtains powdered extract；
4) above-mentioned powdered extract is poured into blender, and oil, beeswax and vaseline is added, stirred in blender equal
It is even, the antibacterial cream of erysipelas can be obtained.
6. the preparation method of the antibacterial cream of erysipelas according to claim 5, which is characterized in that in step 4), agitator speed
It is to be stirred 15min under the conditions of 120~250r/min.
7. a kind of antibacterial cream of erysipelas as described in claim 1-4 is any is preparing the antibacterial of skin and/or analgesic and/or promoting blood circulation
And/or removing toxic substances and/or detumescence and/or anti-inflammatory drug in purposes.
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Cited By (1)
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| CN112156147A (en) * | 2020-11-10 | 2021-01-01 | 湖南省卿和玖安中医药科技有限公司 | Detoxicating and anti-inflammatory ointment |
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| CN108553620A (en) * | 2018-05-30 | 2018-09-21 | 武汉润禾生物医药有限公司 | A kind of bacteriostasis spray and preparation method thereof for treating skin psoriasis |
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| CN112156147A (en) * | 2020-11-10 | 2021-01-01 | 湖南省卿和玖安中医药科技有限公司 | Detoxicating and anti-inflammatory ointment |
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Application publication date: 20190118 |