CN106361875A

CN106361875A - Composition with sweating stopping and odor removing functions

Info

Publication number: CN106361875A
Application number: CN201610957004.8A
Authority: CN
Inventors: 王明媚; 王文信
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-11-04
Filing date: 2016-11-04
Publication date: 2017-02-01

Abstract

The invention provides a composition with sweating stopping and odor removing functions. The main ingredients of the composition are plant extracts including an ash bark extract, a magnolia flower extract, a Chinese magnoliavine fruit extract, a radix sophorae flavescentis extract, a mulberry leaf extract and the like. The composition has the sweating stopping and odor removing functions, the effects are rapid to achieve and lasting, the purpose can be achieved through multiple modes, and meanwhile experiment results show that the safety of the composition is good.

Description

The compositionss that a kind of hidroschesis eliminates the unusual smell

Technical field

The invention belongs to chemical field, be related to a kind of there is hidroschesis eliminate the unusual smell the compositionss of function, more particularly to a kind of The hidroschesis that has containing plant extract eliminates the unusual smell the compositionss of function.

Background technology

Perspire is that a lot of mammals including humans maintain and control the extremely important physiological function of body temperature.Row Antiperspirant by aqueous water being become the phase change of water vapour and water vapour being evaporated the heat to distribute in body, thus preventing body Temperature is too high, makes animal existence in hot environment.

The mankind are organized as sweat gland, including eccrine gland and two kinds of apocrine gland for perspire.Eccrine gland is used for adjusting body temperature, number Measure as 2,000,000-400 ten thousand/people.Eccrine gland in foot distribution at most, is distributed less, its major function is to be arranged by skin at back Antiperspirant, moisture evaporation make body temperature control at 37 DEG C about.The pressure of spiritual aspect also can cause the response of eccrine gland, causes to slap The heart and sole perspire.Eccrine gland secretes the perspiration of 1-2l daily under normal circumstances.The composition of the perspiration of eccrine secretion depends on The speed by sweat duct for the juice, its main component is water, and solids content (part by weight) is 0.03%-0.08%, and solid becomes Divide and include sodium chloride, micro lactic acid and carbamide.

Apocrine gland be secretion abnormal smells from the patient body of gland, unrelated with thermoregulation, focus primarily upon oxter, circumference of eyes, scalp and The positions such as genitals.Emotion changes can affect the secretion of apocrine gland.Eccrine gland can be with the substantial amounts of perspiration of rapid secretion, and apocrine gland Perspiration is secreted with slower speed.The perspiration of apocrine secretion is viscous milk sample shape emulsion, containing protein, lipid, carbon water Compound and salt.

In perspiring produced problem, the most bothersome is the abnormal flavour that oxter perspires generation.Perspiration be in itself aseptic, Tasteless and colourless liquid, the secretions containing big eccrine gland.The generation of abnormal flavour is relevant with oxter bacterial number, its main source It is the less apocrine secretion thing containing Organic substance of secretory volume.Eccrine secretion thing provides necessary moisture for bacterial growth, Armpit hair provides, for apocrine gland perspiration, the place assembled again simultaneously, increases and is suitable to vegetative area.

At present, treatment body surface abnormal flavour mainly has fragrant screening method, antiperspirant method, sterilization several method.Fragrant screening method only relies on fragrance Agent is difficult to complete covering smell；Antiperspirant method perspires to eliminate abnormal flavour using Drug inhibition such as aluminium salt, but medicine acting duration Not long, body surface regenerates abnormal flavour after recovering to perspire；Sterilization adopts antibiotic etc to kill the antibacterial on pedal skin Or funguses, make perspiration cannot decompose generation abnormal flavour, but sweat gland secretion perspiration is not acted on.All there is certain lacking in these methods Fall into, therapeutic effect is unsatisfactory.

Content of the invention

For the defect overcoming " background technology " part to be reflected, the present invention provides a kind of having containing plant extract Hidroschesis eliminates the unusual smell the compositionss of function, and the main component of said composition is Cortex Fraxini, Flos Magnoliae, Fructus Schisandrae Chinensis, Radix Sophorae Flavescentiss, Folium Mori extract.

The compositionss that a kind of hidroschesis eliminates the unusual smell, including Cortex Fraxini, Flos Magnoliae, Fructus Schisandrae Chinensis, Radix Sophorae Flavescentiss, Folium Mori extract, Cortex Fraxini, pungent The name for ancient tribes in the east, Fructus Schisandrae Chinensis, Radix Sophorae Flavescentiss, the parts by weight of Folium Mori extract are:

Cortex Fraxini extract 0.01-5 part；

Flos Magnoliae extract 0.01-5 part；

Fructus Schisandrae Chinensis extrat 0.01-5 part；

Radix Sophorae Flavescentis extract 0.01-5 part；

Folium Mori extract 0.01-5 part.

Preferred version, Cortex Fraxini, Flos Magnoliae, Fructus Schisandrae Chinensis, Radix Sophorae Flavescentiss, the parts by weight of Folium Mori extract are:

Cortex Fraxini extract 0.01-3 part；

Flos Magnoliae extract 0.01-3 part；

Fructus Schisandrae Chinensis extrat 0.01-3 part；

Radix Sophorae Flavescentis extract 0.01-3 part；

Folium Mori extract 0.01-3 part.

More preferably scheme, Cortex Fraxini, Flos Magnoliae, Fructus Schisandrae Chinensis, Radix Sophorae Flavescentiss, the parts by weight of Folium Mori extract are:

Cortex Fraxini extract 0.01-1 part；

Flos Magnoliae extract 0.01-1 part；

Fructus Schisandrae Chinensis extrat 0.01-1 part；

Radix Sophorae Flavescentis extract 0.01-1 part；

Folium Mori extract 0.01-1 part.

Cortex Fraxini nature and flavor bitter cold, is heat clearing and damp drying Chinese medicine, has heat clearing and damp drying, astringent therapy effect.Modern pharmacological research shows the Qin The fraxetin that skin contains being capable of effective hidroschesis.Fructus Schisandrae Chinensis sweet in the mouth, acid, warm in nature, tool is astringed the lung, and nourishing kidney is promoted the production of body fluid, receipts antiperspirant, arresting seminal emission effect, For body void hidrosis, spontaneous perspiration, the disease such as night sweat.Flos Magnoliae is pungent, temperature, dispersing wind and cold, killing parasites for relieving itching.Radix Sophorae Flavescentiss heat clearing and damp drying, wind dispelling insecticide, main Control skin pruritus, noxious dampness skin infection.Folium Mori are sweet, bitter, tremble with fear, dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.Modern study shows Folium Mori Extract has strong inhibitory action to methioninase, and methioninase is to decompose the human chitinase that Methionine is methanthiol, first sulfur Alcohol is to lead to one of main component of bed body smell, therefore Folium Mori have the effect of significantly eliminating the unusual smell.Cortex Fraxini, the five tastes in composite formula Son is monarch drug, restrains hidroschesis；Radix Sophorae Flavescentiss, Folium Mori are ministerial drug, heat clearing and damp drying；Flos Magnoliae is adjuvant drug, scattered wind anthelmintic.All medicines are worked in coordination with, and play altogether Hidroschesis, the effect of eliminate the unusual smell.

Cortex Fraxini is Oleaceae plants fraxinus rhynchophylla Hance fraxinus rhynchophylla hance, Chinese ash fraxinus Chinensis roxb., sharp leaf Chinese ash fraxinus szaboana lingelsh. or place post Chinese ash fraxinus Stylosa lingelsh. is dried branch skin or dried bark.Fructus Schisandrae Chinensis are magnoliaceae schisandra schisandra Chinensis (turcz.) baill.'s or schisandra chinensis schisandra sphenanthera rehd.et wils. is dry Dry mature fruit.Flos Magnoliae is Magnoliacea plant Flos Magnoliae magnolia biondii pamp., Magnolia denudata magnolia denudata Desv. or Flos Magnoliae magnolia sprengeri pamp. dry flower.Radix Sophorae Flavescentiss are leguminous plant Radix Sophorae Flavescentiss sophora The dry root of flavescens ait..Folium Mori are the dried leaves of moraceae plants mulberry morus alba l..Above-mentioned Chinese medicine is all existing The extracting solution of commercialization or extract, can directly buy from relevant market.

Further, compositionss also include antiperspirant, and antiperspirant can make compositionss have more excellent antiperspirant performance.Only Diaphoretic is selected from the mixture of aluminium salt, zirconates or aluminum/zirconates, such as chlorination hydroxyl zirconium aluminum complex, the cooperation of chlorination hydroxyl zirconium aluminum glycine One or more of thing, aluminum chloride.Antiperspirant is specifically chosen any or which is planted and is not particularly limited, people in the art Member is practiced according to art technology routine.The parts by weight of antiperspirant are 5-25 part, and more preferably 5-20 part is optimum Elect 10-18 part as.

Further, compositionss also include having skin moistening, releive, antiinflammatory, pain relieving, promote the conventional plant of wound healing function Thing extract, such as hamamelis extract, sage extract, Aloe extract, Herba Equiseti Hiemalis extract, camomile extract, perfume (or spice) Thatch extract.Aloe extract has the effect of skin moistening, Tramal.Camomile extract has that anti-inflammation and sterilization, Tramal are antipruritic, helps The effect of wound healing.Hamamelis extract have antiinflammatory releive, restrain, the effect of antibacterial, can restrain pore, adjust oils and fatss and divide Secrete, play moisturizing and only act in vain.Sage extract is astringent, peculiar smell removal agent, skin conditioner, skin protective agent, tool Console, nourish, eliminate the unusual smell effect.Herba Equiseti Hiemalis extract be isostearyl glyceryl pentaerythrityl ether, skin conditioner, have console, nourishing effect.Herba Cymbopogonis Citrari carries Thing tool sterilization fragrance is taken to eliminate the unusual smell effect.Above plant extract is specifically chosen any or which is planted and its in the composition Parts by weight are not particularly limited, and those skilled in the art are practiced according to art technology routine.

Further, compositionss also include quintessence oil, such as Radix Vladimiriae quintessence oil, Herba Pogostemoniss quintessence oil, Cortex cinnamomi japonici (Ramulus Cinnamomi) quintessence oil, cinnamon spirit Oil, Basil Essential, Herba Lysimachiae foenum-graeci quintessence oil, Flos Rosae Rugosae quintessence oil, sandalwood essential oil, Peppermint essential oil, cubeb litsen tree quintessence oil, Oleum Anisi Stellati, Herba Origani Vulgaris quintessence oil, Tea tree ethereal oil, rosemary ethereal oil, further strengthen fragrance eliminate the unusual smell, bactericidal effect.Above-mentioned quintessence oil can use mill run, Microencapsulation product can partly or entirely be adopted.Quintessence oil is specifically chosen any or which is planted and its weight portion in the composition Number is not particularly limited, and those skilled in the art are practiced according to art technology routine.

Further, compositionss also include one of wetting agent, emollient, surfactant, antibacterial, preservative or Multiple.Antibacterial can make compositionss have more excellent bactericidal property.Antibacterial include benzalkonium chloride, Bian rope oronain, poly- six One or more of di-2-ethylhexylphosphine oxide guanidine hydrochloride, iodo propinyl n-butyl carbamate.Wetting agent can be trehalose, thoroughly The conventional wetting agents such as bright matter acid sodium.Emollient can be hydro carbons, glyceride, ethers, fatty alcohol and silicone derivative etc..Sterilization Agent, wetting agent, emollient, surfactant, the concrete species of preservative, composition and its parts by weight in the composition are no special Different restriction, those skilled in the art are practiced according to art technology routine.

Live in above-described antiperspirant, conventional plant extract, quintessence oil and microencapsulation quintessence oil, wetting agent, emollient, surface Property agent, antibacterial, preservative etc. all have been realized in commercialization, can directly from relevant market buy.

Compositions as described above, can be used in preparing the medicine that hidroschesis eliminates the unusual smell or health product (have hidroschesis remove different Function of odor but other products of being not belonging to medicine can be considered as health product, for example there is hidroschesis and eliminate the unusual smell the specific use of function Cosmetics).Said composition can realize, by various ways, the purposes that hidroschesis eliminates the unusual smell, for example, be configured to water preparation, gel, cream Agent, emulsion formulations, spray agent, ballpoint preparation or stick formulation, wet tissue etc..

The compositionss that the hidroschesis that the present invention provides eliminates the unusual smell, have hidroschesis and the two kinds of functions that eliminate the unusual smell concurrently, rapid-action, effect is held Long.The main component of compositionss is plant extract, test result indicate that the safety of said composition is good.

Specific embodiment

Below by embodiment, embodiments of the present invention are further illustrated.It should be noted that the present invention Scope be not limited to described embodiment.Any technology essential factor in described embodiment is carried out identical or equivalent Replace obtain technical scheme or those skilled in the art on the basis of described embodiment without creative work just The technical scheme that can obtain, all should be contemplated as falling within protection scope of the present invention.

Compositionss embodiment 1-10:

Illustrate:

1st, the corresponding digital expression component parts by weight in the composition of each component in table.

2nd, the brij-35 in table represents Brij-35.

Embodiment 1-10 preparation method: weigh raw material by above formula, sequentially add, stirring and dissolving uniformly obtains final product medicinal liquid. Above-mentioned medicinal liquid is loaded spray bottle, packs and obtain final product spray；Above-mentioned medicine liquid irrigation is loaded liniment bottle, obtains final product liniment；Will be above-mentioned Medicinal liquid sprays or is impregnated on non-woven fabrics, and cutting sealing packaging obtains final product wet tissue.

Compositionss embodiment 11-17:

Illustrate:

2nd, the brij-35 in table represents Brij-35.

Embodiment 11-17 preparation method: weigh raw material by above formula, sequentially add, stirring and dissolving uniformly obtains final product medicinal liquid. Above-mentioned medicinal liquid is sprayed or is impregnated on non-woven fabrics, cutting sealing packaging obtains final product wet tissue.

Compositionss embodiment 18-20:

Embodiment	18	19	20
				Cortex Fraxini extract	0.2	0.2	0.2
Flos Magnoliae extract	0.2	0.2	0.2
				Fructus Schisandrae Chinensis extrat	0.2	0.2	0.2
Radix Sophorae Flavescentis extract	0.2	0.2	0.2
				Folium Mori extract	0.2	0.2	0.2
brij-35	4	10	12
				Propylene glycol	5	5	5
Chlorination hydroxyl zirconium aluminum aminoacetic acid complex	20	20	20
				Aloe extract	\	\	0.1
Sage extract	0.1	0.1	0.1
				Tea tree ethereal oil	0.02	0.02	0.02
Trehalose	1	1	1
				Bian rope oronain	0.05	0.05	0.05
Vitamin e	0.5	0.5	0.5
				Jojoba oil	3	15	3
Peg-26 glycerin ether	3	3	3
				D- pantothenylol	0.5	0.5	0.5
8% arabic gum	8	4	4
				Glyceryl stearate	\	5	\
Water	68.33	62.33	60.23
				Dosage form	Gel	Emulsifiable paste	Ballpoint

Illustrate:

2nd, the brij-35 in table represents Brij-35.

Embodiment 18-20 preparation method: weigh raw material by above formula, prepare by the common process of dosage form described in table, This dosage form can be obtained.

Embodiment skin irritation evaluation experimental:

From healthy rabbits, male and female half and half, it is administered first 24 hours by back part of animal spinal column both sides with operating scissorss cropping not Injured skin, goes gross area to be 10 × 10cm², after unhairing, animal is randomly divided into intact skin group and damaged skin group, every group 5 Only, hair-fields will be gone on the left of intact skin group rabbit to give embodiment product, consumption 4g, right side blank (containing only pure water), after administration Covered with one layer of sterilization oilpaper and two-layer antiseptic gauze, immobilization with adhesive tape.Before the administration of damaged skin group animal, skin coarse sandpaper is wiped Hinder the skin of the left and right sides, to abrade epidermis, make similar toenail scrape the scratch grabbing generation, but must not bleeding, only scratch angle Matter layer and lossless skin corium, medication is the same.Be administered latter 6 hours remove cover, observe respectively and record 1,24,48 hours to Medicine position has or not situations such as erythema and edema.Every animal test results carry out skin irritation reaction scoring by table 1, calculate flat All score values, embodiment appraisal result is shown in Table 2, table 3.

Table 1 skin irritation reacts standards of grading

Table 2 embodiment is to intact skin irritative response result

Table 3 embodiment is to damaged skin irritative response result

Test result indicate that, example composition is zero to rabbit normal skin irritant reaction score value, shows nonirritant. The average response value that example composition stimulates to injured skin is also zero, shows to injured skin also nonirritant.

Embodiment eliminate the unusual smell effect assessment experiment:

Using olfactory test method, 20 bromhidrosis volunteers, age 18-30 year, patient is divided with slight/severe, i.e. opposite Check apart from 30cm, exposed can smell abnormal smells from the patient person be slight, directly smell abnormal smells from the patient the greater for severe, every 4 patients are one group, Include 1 severe volunteer, 3 slight volunteers respectively.Apply oxter with example composition respectively, consumption is 4g, Ran Houjin Row is evaluated, and the elimination abnormal flavour persistent period averages.Carry out next group experiment, until whole embodiments compositionss are evaluated after 15 days Complete.Embodiment evaluation result is shown in Table 4.

Table 4 embodiment eliminates the unusual smell effect

Embodiment	Onset time	Persistent period
			1	Immediately	2 days
2	Immediately	2 days
			3	Immediately	3 days
4	Immediately	3 days
			5	Immediately	3 days
6	Immediately	3 days
			7	Immediately	2 days
8	Immediately	3 days
			9	Immediately	4 days
10	Immediately	4 days
			11	Immediately	4 days
12	Immediately	4 days
			13	Immediately	4 days
14	Immediately	4 days
			15	Immediately	4 days
16	Immediately	4 days
			17	Immediately	4 days
18	Immediately	4 days
			19	Immediately	4 days
20	Immediately	4 days

Test result indicate that, example composition has splendid dispelling abnormal flavor effect.Meanwhile, no any in experimentation Situations such as one embodiment cenesthesia exception, red swelling of the skin, occurs it was demonstrated that embodiment product is to armpit skin nonirritant.

Embodiment antiperspirancy performance evaluation experimental:

Using 2003 editions methods of fda " otc hidroschesis medicine validity test standard ", example composition antiperspirancy performance is entered Row test.3g example composition is sprayed or is coated in the oxter of 30 female volunteers, carry out the experiment of hot room, calculate average antiperspirant weight Decrement.Every 5 volunteers of embodiment, carry out next group experiment, until whole embodiments compositionss evaluation completes after 15 days.Real Test and the results are shown in Table 5.

Table 5 embodiment of the present invention antiperspirancy performance

Test result indicate that, example composition is respectively provided with splendid antiperspirant efficacy.Meanwhile, stingless in experimentation Swash, allergy situations such as occur it was demonstrated that the safety of example composition is good.

When the medicine being eliminated the unusual smell using the hidroschesis of example composition preparation or health product, original amounts can be according to except different 3g-4g compositionss are once sprayed or are coated in body by the usage amount in the experiment of taste effect assessment or antiperspirancy performance evaluation experimental Table, afterwards Different Individual suitably increase and decrease consumption according to practical effect.

Claims

1. the compositionss that a kind of hidroschesis eliminates the unusual smell are it is characterised in that described compositionss include Cortex Fraxini, Flos Magnoliae, Fructus Schisandrae Chinensis, hardship Ginseng, Folium Mori extract, described Cortex Fraxini, Flos Magnoliae, Fructus Schisandrae Chinensis, Radix Sophorae Flavescentiss, the parts by weight of Folium Mori extract are:

Cortex Fraxini extract 0.01-5 part；

Flos Magnoliae extract 0.01-5 part；

Fructus Schisandrae Chinensis extrat 0.01-5 part；

Radix Sophorae Flavescentis extract 0.01-5 part；

Folium Mori extract 0.01-5 part.

2. compositionss according to claim 1 are it is characterised in that described Cortex Fraxini, Flos Magnoliae, Fructus Schisandrae Chinensis, Radix Sophorae Flavescentiss, Folium Mori carry Take thing parts by weight be:

Cortex Fraxini extract 0.01-3 part；

Flos Magnoliae extract 0.01-3 part；

Fructus Schisandrae Chinensis extrat 0.01-3 part；

Radix Sophorae Flavescentis extract 0.01-3 part；

Folium Mori extract 0.01-3 part.

3. compositionss according to claim 1 are it is characterised in that described Cortex Fraxini, Flos Magnoliae, Fructus Schisandrae Chinensis, Radix Sophorae Flavescentiss, Folium Mori carry The parts by weight taking thing are:

Cortex Fraxini extract 0.01-1 part；

Flos Magnoliae extract 0.01-1 part；

Fructus Schisandrae Chinensis extrat 0.01-1 part；

Radix Sophorae Flavescentis extract 0.01-1 part；

Folium Mori extract 0.01-1 part.

4. the compositionss according to any one of claim 1-3 are it is characterised in that described compositionss also include antiperspirant, Described antiperspirant is one or more of chlorination hydroxyl zirconium aluminum complex, chlorination hydroxyl zirconium aluminum aminoacetic acid complex, aluminum chloride, The parts by weight of described antiperspirant are 5-25 part.

5. compositionss according to claim 4 are it is characterised in that the parts by weight of described antiperspirant are 10-18 part.

6. compositionss according to claim 4 are it is characterised in that described compositionss also include hamamelis extract, Mus One or more of tail grass extract, Aloe extract, Herba Equiseti Hiemalis extract, camomile extract, Herba Cymbopogonis Citrari extract.

7. compositionss according to claim 6 are it is characterised in that described compositionss also include quintessence oil, described quintessence oil For Radix Vladimiriae quintessence oil, Herba Pogostemoniss quintessence oil, Cortex cinnamomi japonici (Ramulus Cinnamomi) quintessence oil, cinnamon essential oil, Basil Essential, Herba Lysimachiae foenum-graeci quintessence oil, Flos Rosae Rugosae quintessence oil, Lignum Santali Albi essence One or more of oil, Peppermint essential oil, Oleum Anisi Stellati, Herba Origani Vulgaris quintessence oil, tea tree ethereal oil, rosemary ethereal oil.

8. compositionss according to claim 7 are it is characterised in that described quintessence oil is partly or entirely microencapsulation quintessence oil.

9. compositionss according to claim 7 are it is characterised in that described compositionss also include wetting agent, emollient, table One or more of face activating agent, antibacterial, preservative.

10. the compositionss described in any one of claim 1-9 are for preparing the purposes of the medicine that hidroschesis eliminates the unusual smell or health product.