KR102037030B1 - Cosmetic composition for improving acne containing Phytosilica - Google Patents

Abstract

The present invention relates to a cosmetic composition for reducing acne containing phytosilica. More particularly, the present invention has an excellent effect on reducing acne by promoting skin regeneration due to activation of the immune system by containing phytosilica, which is a fine needle, extracted from plants and a natural complex extract as an active ingredient.

Description

Cosmetic composition for improving acne containing Phytosilica {Cosmetic composition for improving acne containing Phytosilica}

The present invention relates to a cosmetic composition for improving acne containing phytosilica, and more particularly, to contain acne phytosilica and natural complex extracts extracted from plants as an active ingredient acne by promoting skin regeneration by activating the immune system A cosmetic composition having an excellent effect on improvement.

Acne is an inflammatory skin disease that occurs in hair follicles and sebaceous glands. Acne causes increased sebum secretion by male hormones, increased exfoliated hair follicle walls, inflammation caused by the propagation of Propionibacterium acnes (P. acnes), skin barrier abnormalities, genetic and environmental factors, It can be caused by a combination of hair follicle reactivity.

Acne promotes sebaceous secretion of male hormones, and the pores, the pores, are filled with thick keratin. In order to cope with these reactions, the immune response begins, white blood cells accumulate, which causes inflammation, clogged pores, and the sebum and keratin are not mixed.

Treatments for acne can be divided into two categories: drug, pill and surgical treatment. Treatments for acne have been developed in terms of inhibiting sebum overproduction, preventing hyperkeratosis of hair follicle walls, inhibiting proliferation of P. acnes and preventing inflammatory reactions. However, currently used drugs such as erythromycin, isotretinoin, benzoyl peroxide, vitamin A acid, triclosan and azelaic acid are used for nasal mucosa and mucous membranes. In addition to the side effects of dryness, teratogenicity, blemishes or thrombosis, it is known that there are many problems such as the emergence of antibiotic resistant strains and recurrence when discontinuing treatment.

Surgical treatments include steroid injection, extrusion, dermabrasion, and photodynamic therapy. Also, the treatment of scars caused by acne includes chemical dermabrasion, fractional laser, filler, skin regeneration laser, scar resection, steroid injection therapy, and cryotherapy.

All the treatment methods described above have the disadvantage of accumulating physical and chemical stress on skin and cell tissues, and also causing trauma or bleeding.

 Meanwhile, a skin care cosmetic composition is disclosed using spongy bone fragments. It uses bone fragments of sponges that live in fresh water or in the sea. In order to utilize the spongy bone fragments, a chemical purification process using an acid or a base is used, and abrasives are contained, and thus there is a limit to use as a cosmetic. Sodium hydroxide residues during the refining process result in strong alkalis in the manufacture of cosmetics and may cause skin dryness, and may cause redness, excessive irritation, itching, allergies and troubles. In addition, skin immunity may decrease with prolonged use. The finer the sponge, the higher the price, and the higher the amount of sponges collected each year. However, due to the limitation of biological resources, productivity is irregular and there is a risk of extinction in the long term.

Therefore, there is a need for the development of natural plant-derived cosmetic products that are not only safe for the human body but also have excellent skin improvement effects for the treatment and improvement of acne.

KR1020060097013 A

The present invention is to solve the above problems of the prior art, an object of the present invention is to provide a cosmetic composition for improving acne containing phytosilica which is a plant-derived micro needle harmless to the human body.

Another object of the present invention is to provide a cosmetic composition for improving acne having an excellent effect on anti-acne and anti-inflammatory, skin regeneration, skin barrier function improvement by including phytosilica and complex extract as an active ingredient.

Still another object of the present invention is to provide a cosmetic composition for preventing and improving acne that is excellent in stability and can be safely used without any side effects on the skin.

In order to achieve the object, the present invention is phytosilica; And it provides a cosmetic composition for improving acne comprising a liver extract, yellow baekbaek extract, rhubarb extract, spectral extract, aloe vera extract, a loofah myoberry extract as an active ingredient.

In the present invention, the phytosilica is characterized in that it is obtained from plants as fine needles.

In addition, the plant is characterized in that Arkocaps phytosilica (Arkocaps phytosilica).

In addition, the average length of the particles of the phytosilica may be 100 to 300㎛, the width may be 10 to 20㎛.

In addition, the phytosilica may be contained 0.01 to 7.0% by weight based on the total weight of the composition.

In addition, the complex extract is a liver extract, yellow white extract, rhubarb extract, spectral extract, aloe vera extract and scrubber fruit extract is 0.9 to 1.1: 0.4 to 0.6: 0.4 to 0.6: 0.09 to 0.11: 0.09 to 0.11: 0.09 to 0.11 It is included as a weight ratio of, the content of the complex extract may be contained 0.1 to 10% by weight relative to the total weight of the composition.

In addition, the complex extract is water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, hexane and mixtures thereof Solvent extraction method using an extraction solvent selected from the group consisting of; And high temperature vacuum extraction; It may be extracted through any one extraction method selected from among.

In addition, the liver liver extract, sulfur white extract, yellow lotus extract and spectral extract, the liver, yellow white, yellow lotus and the crowd, respectively, (a) washing step; (b) 20 to 50 minutes steaming at 80 to 100 ℃ and then hot air dried at 50 to 70 ℃ for 7 to 9 hours; (c) secondary steaming at 80-100 ° C. for 20-50 minutes; (d) lyophilized and milled; (e) mixing the solvent to prepare a mixed solution; (f) refining the mixed solution with an ultrasonic mill; And, (g) after centrifugation, the supernatant is recovered and dried after filtration.

In one embodiment of the present invention, the total weight of the composition may further comprise 0.1 ~ 1.5% by weight of Bacopamonniera extract, 0.05 ~ 0.15% by weight tea tree oil, 0.2 ~ 3% by weight of niacinamide.

In one embodiment of the present invention, the cosmetic composition is a rosemary leaf extract, green tea extract, bergamot leaf extract, lavender flower extract, Western rose flower extract, Centella asiatica extract, Rhododendron extract, golden extract, Spanish licorice root extract, chamomile flowers Extract, may be extracted may further include a herb extract consisting of one or more extracts selected from the group consisting of extracts, gooseberry seed extract, mugwort extract.

In one embodiment of the present invention, the cosmetic composition may further comprise one or more of Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF).

In one embodiment of the present invention, the composition may be for improving acne having antibacterial, anti-inflammatory, skin soothing, whitening, sebum secretion and skin regeneration promoting function.

In one embodiment of the present invention, it is selected from the group consisting of softening cream, nutrient cream, nutrition cream, gel, ampoule, eye cream, cream, gel, cleansing foam, cleansing water, pack, massage cream, essence, spray and powder It may be formulated in one or more.

The cosmetic composition according to the present invention has an effect of making phytosilica, which is a microneedle extracted from a plant, into healthy skin by activating the skin's immune system, promoting skin regeneration, and promoting the turnover cycle of the skin.

In addition, phytosilica is obtained from plants and is free of skin irritation and is safe for human body.

In addition, phytosilica can maximize the synergistic effect of the composite extract and the herbal extract as an effective delivery means of the active ingredient in the skin.

The cosmetic composition according to the present invention has excellent antibacterial and anti-inflammatory effects, and has an excellent effect on acne relief and improvement.

In addition, it is effective in improving skin elasticity, whitening, skin moisturizing, skin soothing.

1 is an electron micrograph showing phytosilica according to the present invention.
(a) is a 100-fold magnification of phytosilica, (b) a 300-fold magnification of phytosilica, and (c) a 400-fold magnification of phytosilica.
Figure 2 is a chart showing the visual evaluation results suitable for use on acne skin according to the evaluation scale of the global acne grading system (GAGS) according to an embodiment of the present invention.
3 is a diagram showing a result of sebum improvement evaluation by Sebumeter according to an embodiment of the present invention.
4 is a table showing skin tone improvement evaluation results by SkinColorCatch and a video microscope according to an embodiment of the present invention.
Figure 5 is a photograph of the test analysis suitable for use on acne skin according to an embodiment of the present invention.
Figure 6 is a photograph of skin tone analysis before and after use of the composition according to an embodiment of the present invention.
Figure 7 is a photograph before and after skin tone analysis of the composition according to an embodiment of the present invention.
Figure 8 is a photograph before and after skin tone analysis of the composition according to an embodiment of the present invention.

The terminology used herein is to select general terms as widely used as possible in consideration of the functions in the present invention, but may vary according to the intention or precedent of the person skilled in the art, the emergence of new technologies and the like. In addition, in certain cases, there is a term arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the corresponding description of the invention. Therefore, the terms used in the present invention should be defined based on the meanings of the terms and the contents throughout the present invention, rather than the names of the simple terms.

According to an aspect of the invention, phytosilica; And it provides a cosmetic composition for improving acne comprising a liver extract, yellow baekbaek extract, rhubarb extract, spectral extract, aloe vera extract, a loofah myoberry extract as an active ingredient.

Since the cosmetic composition contains a natural extract as an active ingredient, the skin improving effect, antibacterial, anti-inflammatory effect and skin regeneration effect is excellent and the acne improvement effect is very excellent. In particular, the cosmetic composition may be significantly improved skin improvement effect compared to the cosmetic composition containing a single extract individually due to the synergistic effect of each component contained in the complex extract. In addition, since the cosmetic composition includes the phytosilica, the penetration rate of the active ingredient of the complex extract in the skin may be significantly increased.

Phytosilica (Phytosilica) can be obtained in powder form as a crystalline genus and biologically active substance in the form of microneedle extracted from plants.

The phytosilica is a bio-new material that is harmless to the human body. It is a needle-like structure with capillaries. Make.

In addition, the needle-like structure in which the capillary tube of the phytosilica is formed may penetrate the skin layer to form a micro passage, thereby significantly increasing the penetration effect of the applied cosmetic component.

The phytosilica may be obtained from Arkocaps phytosilica. The Arkocaps phytosilica is a plant native to Europe, and belongs to rice and grass, and is called Birdseed grass or Canary grass. It is distributed in the tropics mainly in the temperate zone of the northern hemisphere and grows in the grass of fields or watersides. It was grown as a herb in Sweden in 1749 and in parts of Northern Europe around 1850. Root stems grow to the side, and the stem grows straight to 70 ~ 180cm in height. The leaf body is 20 ~ 30cm long and 12mm wide. The leaf is membranous and 3 ~ 4mm. Conical inflorescences are about 15cm long and bloom in June. Small spikes are densely lined with short branches. Small spikes are 4-5mm long, flat to the left and right, with one full flower in the middle. The glume is membranous, 3 ~ 3.5mm long, with 3 veins. Fruiting externals are about 3mm long, hairy, and cheap. Unfaithful external hair, hairy, about 1mm long, 3 surgeries. Fruits ripen in October and are widely used as a cow grass.

The phytosilica is safe and harmless to humans because it is a natural vegetable raw material without undergoing chemical purification of acid or base as in animal sponges.

The phytosilica is an effective means of skin regeneration, it can be used to improve hyperpigmentation, fine wrinkles, sun damage and superficial scars, scrim, acne. The fine pores of phytosilica contain the active ingredients and are released after application to the skin to achieve a lasting effect. The phytosilica is micro-sized to reduce stress on skin tissues and cells, and stimulating fibroblasts using simple stimulation promotes blood flow and oxygen transfer, thereby activating the immune system. Increases skin elasticity by promoting collagen production in the dermis. Improves acne's rapid improvement, activates skin cells, improves troubles, improves skin tone, boosts autoimmunity and accelerates skin turnover cycle

In one embodiment, the average length of the particles of the phytosilica may be 100 to 300㎛, the width may be 10 to 20㎛. Preferably the average length is 250 μm and the width may be 15 μm. If the average particle length is less than 100 μm, it may not effectively penetrate into the skin to form a fine stimulus, and if the mean particle size is 300 μm, dispersibility may be degraded or excessive stimulation may be caused to the skin.

In one embodiment, the phytosilica may be contained from 0.01 to 7.0% by weight relative to the total weight of the composition. If the content of the phytosilica is less than 0.01% by weight, the skin penetration improvement effect is not sufficiently realized, and if the content of phytosilica is greater than 7.0% by weight, side effects or skin problems may be caused by skin irritation. Preferably it may be contained in 2 to 4% by weight, more preferably 3% by weight.

On the other hand, the extract refers to a solvent in which the active ingredient contained in the extract material is transferred by contacting the solvent and the extract material under specific conditions. If the extract is a material obtained by extracting a component contained in the raw material from natural products, All may be included, regardless of type. For example, water and an organic solvent may be used to extract all components that are dissolved in a solvent from natural products, specific components of natural products, such as those obtained by extracting only specific components such as oil.

The liver is a stem stem of perennial herbaceous plants belonging to the iris family, and is used as a medicine as a stem (射干), which has anti-inflammatory effect on sore throat, tonsillitis, and lymphadenitis around the neck. It contains isoflavones, tannins and saponins, and promotes the synthesis of hyaluronic acid and the synthesis of collagen.

The baekbaek is a word that leads to the bark of the yellow wall, medicinal hwangpyeongpi. Peel the bark from the trunk before or after the summer to remove the rough skin or cut it and dry it in the sun. This peel is used as a medicine to lower blood sugar. In addition, pneumococcal pneumoniae, pneumococcal tuberculosis, staphylococcus, etc., while inhibiting the development of tumor cells, and inhibits the growth and sterilization.

Huangshan is native to China and is grown in Korea, Japan and China for herbal medicine. It grows on eczema ground in the shade of forests in the mountains. In oriental medicine, the roots of the 5-6 year old Hwangnyeon and Dwarf Soybeans were harvested and dried in the sun, called Hwangnyeon (黄 건).

The spectators are root stems of the perennial herbaceous plant (Dryopteris crassirhizoma Nakai), which grows in shaded wet land in a relatively deep mountain forest of almost all areas of Korea. Young leaves are used for edible, and oriental medicine uses root stem as a medicine. The crowd exhibits antiparasitic, antipyretic, detoxification, cold virus suppression, and antibacterial and anticancer activity, while the decoction of water is known to inhibit skin fungi.

Aloe vera is native to the Mediterranean and Africa. Gel-containing sap contained in the leaves is known to be effective in treating burns and arthritis. It is used for various purposes such as raw materials for food and medicine, edible, etc., and it has been found to be effective in disinfection, fatigue recovery and skin neutralization, antipyretic, constipation and ulcer.

The scrubber is so cold that it cuts away phlegm, which causes a lot of heat in the body. By cooling hot blood, it promotes blood circulation, and it is effective for inflammation of acne, sweat, etc., which is anti-inflammatory. It has a soothing effect, prevents excessive secretion of sebum, and prevents clogging of pores. It is known to supply enough moisture and to prevent itching. It is also known for its anti-obesity, antioxidant, antibacterial and skin cell regeneration effects.

In one embodiment, the complex extract is a liver extract, yellow white extract, rhubarb extract, spectral extract, aloe vera extract and scrubber fruit extract is 0.9 to 1.1: 0.4 to 0.6: 0.4 to 0.6: 0.09 to 0.11: 0.09 to 0.11 It is included in a weight ratio of 0.09 to 0.11, the content of the complex extract may be contained 0.1 to 10% by weight based on the total weight of the composition.

When the complex extract has a large variation in the mixing ratio, the skin improvement effect derived from the active ingredient of each extract may not be properly implemented, and the mixing ratio may be appropriately controlled in consideration of the quality of the final product. Preferably, the complex extract is mixed with liver weight extract, yellowish white extract, yellow lotus extract, spectral extract, aloe vera extract and scrubber fruit extract in a weight ratio of 1: 0.5: 0.5: 0.1: 0.1: 0.1, and the content of the complex extract The silver composition may be contained in an amount of 2 to 3% by weight based on the total weight of the composition, and an optimum skin improvement effect may be realized in the above range.

In one embodiment, the extract of the complex extract may be prepared by a conventional extraction method in the art, preferably water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin , Acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, hexane and a solvent extraction method using an extraction solvent selected from the group consisting of a mixture thereof, can be extracted by high temperature vacuum extraction.

In one embodiment, the aloe vera extract and the scrubber fruit extract may be extracted by high temperature vacuum extraction. The high temperature vacuum extraction method has the advantage of not needing an organic solvent, and can obtain a high-purity undiluted extract, so it is more resistant to bacterial and fungal contamination than the general extraction method, thereby reducing the content of natural preservatives.

In one embodiment, the liver liver extract, yellowish white extract, yellow lotus extract and spectral extract, the liver, yellow white, yellow lotus and the crowd, respectively, (a) washing step; (b) steaming for 20 to 50 minutes at 80 to 100 ° C and drying the hot air at 50 to 70 ° C for 7 to 9 hours; (c) secondary steaming at 80-100 ° C. for 20-50 minutes; (d) freeze drying and grinding; (e) mixing the solvent to prepare a mixed liquid; (f) miniaturizing the mixture with an ultrasonic mill; And, (g) after the centrifuged, the supernatant is recovered and dried after filtration; may be extracted.

The liver, yellowish white, rhubarb and the crowd remove the toxicity through the repeated process of steaming and drying, the steaming process is known as a process to change the components using steam to create a new compound or maximize the useful component dissolution. Steaming and drying the liver, yellowish white, yellow lotus and the crowd can enhance the physiological activity.

On the other hand, the kind of the solvent used in the extraction is not particularly limited, various solvents may be used if necessary. In addition, the extraction may be performed using conventional methods in the art, such as cold needle, warm needle, heating using the solvent.

The extract is composed of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, hexane and mixtures thereof It may be extracted with one or more solvents selected from, and the alcohol may be ethanol at a concentration of 60 to 90% (v / v). In other words, the active ingredient included in the raw material may be different in the extraction ratio according to the polarity of the solvent, the ethanol may be realized an optimal skin improvement effect in the extraction of physiologically active substances of natural raw materials, but is not limited thereto. .

On the other hand, the cosmetic composition may further comprise bacopamonniera extract, tea tri oil, niacinamide.

The Bacopa monnier is a small species of Bacopa, native to Southeast Asian Indians living relatively small and long ovate leaves. Stem is straight, has round leaves, and grows well in acid to neutral water quality. The Bacopamonniera extract contains ingredients such as saponin to give conditioning to the skin and give vitality. It also has antioxidant and anti-inflammatory effects

The tea tree is composed of monoterpene alcohol (monoterpene alcohol) and cineol (cineol) as a major component, it is known to have the effect of antimicrobial, antiviral and immune enhancing.

The niacinamide is a whitening functional ingredient approved by the Korea Food and Drug Administration as a cosmetic safety grade 1, inhibits skin tone improvement and trouble generation, and shows the effect of whitening and skin barrier improvement. In addition, applying it to areas where scars, blemishes, or trouble marks are likely to occur, or areas that are strongly exposed to UV rays, helps to reduce pigmentation.

Specifically, the total amount of the cosmetic composition may include 0.1 ~ 1.5% by weight of Bacopamonniera extract, 0.05 ~ 0.15% by weight of tea tree leaf oil, 0.2 ~ 3% by weight of niacinamide.

If the variation of the ratio of the Bacopamonniera extract, tea tree oil, niacinamide is large, the skin improvement effect derived from each active ingredient may not be properly implemented, the optimum skin derived from the active ingredient in the weight range Improvement effects can be implemented.

In addition, the cosmetic composition may be accompanied by additional skin improvement effects of various aspects such as skin moisturizing and skin soothing effect, skin irritation reducing effect due to the synergistic effect of the additional extract. The cosmetic composition is rosemary leaf extract, green tea extract, bergamot leaf extract, lavender flower extract, western rose flower extract, centella extract, rhododendron extract, golden extract, Spanish liquorice root extract, chamomile flower extract, portuguese extract, citrus seed extract It may further comprise a herb extract consisting of one or more extracts selected from the group consisting of mugwort extract.

Phytosilica can help penetrate these components. Phytosilica makes fine micro holes in the skin and penetrates the active ingredients into the skin. When phytosilica is used to infiltrate the components of herbal extracts, a more positive effect is obtained.

Specifically, the herb extract is rosemary leaf extract 0.01 ~ 2% by weight, green tea extract 0.01 ~ 2% by weight, bergamot leaf extract 0.01 ~ 2% by weight, lavender flower extract 0.01 ~ 2% by weight, Western rose flower extract 0.01 ~ 2% by weight , Centella asiatica extract 0.01 ~ 2% by weight, ephedra root extract 0.01 ~ 2% by weight, golden extract 0.01 ~ 2% by weight, Spanish licorice root extract 0.01 ~ 2% by weight, chamomile flower extract 0.01 ~ 2% by weight, gusset extract 0.01 It may be at least one selected from the group consisting of ~ 2% by weight, citrus seed extract 0.01 ~ 2% by weight, mugwort extract 0.01 ~ 2% by weight.

When the variation in the mixing ratio of each extract is large, since the skin improvement effect derived from the active ingredient of each extract may not be properly implemented, the herbal extract implements the optimal skin improvement effect derived from the active ingredient in the weight range. Can be.

The herbal extract is selected from the group consisting of water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, petroleum ether, ethyl acetate, butyl acetate, trichloromethane, dichloromethane, chloroform, hexane and 1,3-butylene glycol It may be extracted with one or more solvents selected, and the alcohol may be ethanol at a concentration of 60 to 90% (v / v).

The cosmetic composition may further include one or more of epidermal growth factor (EGF) and fibroblast growth factor (FGF).

Epidermal growth factor (EGF) and fibroblast growth factor (FGF) are a kind of peptide that is a natural skin regeneration material that restores damaged skin tissue of the skin epidermis and dermis. EGF is a growth factor that acts on the skin's epidermis, helps skin regeneration, protects skin from external stimuli, and develops its natural strength. FGF acts on the dermal layer of the skin and activates structures such as collagen and elastin in the skin and is a growth factor component that controls wrinkles, sagging and dryness that are directly related to aging.

Phytosilica can help penetrate these active ingredients. Phytosilica makes fine micro holes in the skin and penetrates the active ingredients into the skin. The use of phytosilica to penetrate the cosmetic ingredients of EGF and FGF has a more positive effect. Induces skin regeneration, promotes skin improvement, and secures skin regeneration effect without side effects. In addition, it creates a collagen production system of skin tissue to quickly restore the elasticity increase, skin regeneration, skin turnover cycle.

The cosmetic composition may be for improving acne, characterized in that it has antibacterial, anti-inflammatory, skin soothing, whitening, sebum secretion suppression and skin regeneration promoting function. The cosmetic composition may be effectively penetrating and acting on the skin by the microneedle containing the complex extract containing the skin improvement effect significantly.

The cosmetic composition is one or more selected from the group consisting of flexible cosmetics, nourishing cosmetics, nutrition cream, gel, ampoule, eye cream, cream, gel, cleansing cream, cleansing foam, cleansing water, pack, massage cream, essence, spray and powder It can be formulated as.

The cosmetic composition may be appropriately blended with other ingredients within the range of not impairing the object according to the present invention according to the kind or purpose of use of the formulation in each formulation.

In addition, the cosmetic composition according to the quality or function of the final product, fatty substances, organic solvents, solubilizers, thickeners, softeners, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water commonly used in the industry With ionic or nonionic emulsifiers, fillers, metal ion sequestrants, chelating agents, preservatives, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, and any other ingredients commonly used in cosmetics. It may additionally contain adjuvants commonly used in the same cosmetic or dermatology field.

Hereinafter, the present invention will be described in detail with reference to Examples and Manufacturing Examples. However, embodiments and preparations according to the present invention can be modified in many different forms, the scope of the invention should not be construed as limited to the embodiments and preparations detailed below. Examples and preparations of the present invention are provided to more fully explain the present invention to those skilled in the art.

Preparation Example Preparation of Complex Extract

Preparation Example 1 Preparation of Aloe Vera Extract and Smear Cucumber Fruit Extract

After filling the aloe vera and scrubber fruit with the high temperature vacuum steamer in anhydrous state by using the high temperature vacuum extraction method, the temperature of the heating vessel was heated to 250 ~ 300 ℃ and cooled to 30 ~ 70 ℃ to apply vacuum pressure in the container. Then, the mixture was heated and extracted for 24 hours.

Preparation Example 2 Preparation of Liver Extract, Yellowish White Extract, Rhododendron Extract and Spectrum Extract

After washing the mortar and steaming for 30 minutes at 90 ℃, dried for 8 hours at 60 ℃ in a hot air dryer, and then steamed again at 90 ℃ for 30 minutes, lyophilized and ground to prepare a powder. 2 g of the ground powder was mixed in 1 L of 70% ethanol and refined with an ultrasonic grinder. After centrifugation of the finely divided sand mixture, the supernatant was recovered, filtered and dried to obtain a sand ash extract.

In the same way, the yellow white, yellow lotus and the crowd were extracted.

Preparation Example 1 and Preparation Example 2 were mixed to finally produce a composite extract.

(Example) 0.5 parts by weight of sulfur white extract, 0.5 parts by weight of rhubarb extract, 0.1 parts by weight of aloe vera extract, 0.1 parts by weight of scrubber fruit extract, 0.1 parts by weight of complex extract and phytosilica 3 To prepare a gel in a conventional manner according to the composition of Table 1 including parts by weight (unit: parts by weight)

Ingredient EXAMPLE Purified water 78.000 Phytosilica 3.000 Sagan extract 1.000 Yellow White Extract 0.500 Yellow lotus extract 0.500 Aloe vera extract 0.100 Scrubber Cucumber Extract 0.100 Spectator extract 0.100 Bacopamonniera Extract 1.000 Tea Tree Leaf Oil 0.100 Niacinamide 2.000 Herb Extract 1.900 EGF 0.005 Butylene Glycol 3.000 glycerin 2.000 Sodium hyaluronate 1.000 Carbomer 0.300 Dimethylsulfone 0.100 Allantoin 0.100 Dipotassium glycylizate 0.100 Disodium ID 0.030

In order to evaluate the effect as a cosmetic of the embodiment according to the present invention, the human dermatological research was carried out through the Korean Dermatological Research Institute suitable for use on acne skin, skin tone improvement.

The subjects were performed on 20 adult male and female 20-32 year olds with acne on the voluntarily recruited facial areas as shown in Table 2. The test subject wears a finger wrap after washing the face once a day in the first week of the five weeks of testing, and every other evening from the second week, and crosses the same amount of the embodiment according to the present invention as a test substance to the designated test site of the face. Apply by spreading by pressing.

In order to make the measurement conditions of the test subjects the same, it was measured after stabilization in a constant temperature and humidity room (temperature: 22 ± 2 ℃, humidity: 50 ± 5%) for 30 minutes after washing with the same face wash at the Korean Dermatological Research Institute.

The measurement method consisted of the evaluation of sebum improvement by Sebumeter and the naked eye evaluation suitable for acne skin according to the evaluation scale of Global acne grading system (GAGS).

(Test 1) Visual evaluation suitable for use on acne skin according to the evaluation scale of Global acne grading system (GAGS)

For the visual evaluation of the test substance suitable for use on acne skin, the investigator performed a visual evaluation according to the degree of acne lesions based on the GAGS evaluation scale. Evaluate and derive the severity of acne by the 0-4 points (0 = Nil, 1 = Comedone, 2 = Papule, 3 = Pustule, 4 = Nodule) according to the severity of acne lesions. The mean value of one score was calculated and used for analysis. The decrease in severity of acne compared to before use of test substance means that it is suitable for use on acne skin. Evaluations were made before use of the test substance, after 2 weeks, after 4 weeks, and after 5 weeks. The evaluation results are as shown in Tables 3 to 5 and FIG. 2.

The severity of acne decreased by 53.04% after 2 weeks, 62.86% after 4 weeks, and 70.41% after 5 weeks. In addition, it was statistically significant after 2 weeks, 4 weeks, and 5 weeks after the use of the test substance (p <.001). The test substance was found to be suitable for acne skin.

(Test 2) Sebum improvement evaluation by Sebumeter

Sebumeter (SKIN-OMAT, Cosmomed GmbH, Germany) was applied to evaluate the sebum improvement of acne skin. In the measurement of sebum amount, the same test personnel contacted the probe cassette with oil adsorption tape on the left nostril of all subjects at the same pressure for 30 seconds, adsorbed the oil, and then inserted it into the main body. Sebumeter analyzes the amount of oil that comes out after attaching a special semi-transparent lipid absorbing tape to the skin by using photometric reflection. The unit of measurement is ㎍ / ㎠ and the maximum value is 350. As the measured value decreased compared to before the test substance was used, sebum improved. Instrument measurements were taken before, after 2 weeks, after 4 weeks, and after 5 weeks of use. Evaluation results are as shown in Tables 6 to 8 below.

As a result of sebum improvement analysis using sebumeter, sebum volume decreased by 40.51% after 2 weeks, 42.92% after 4 weeks, and 47.40% after 5 weeks compared to before using test substance. It was. In addition, after 2 weeks, 4 weeks, and 5 weeks after the use of the test substance, it was statistically significant (p <.001), and it was confirmed that the test substance helped to improve sebum.

(Test 3) Skin tone improvement evaluation by SkinColorCatch and video microscope

SkinColorCatch (Delfin Technologies Ltd., Finland) and video microscope (KONG PC Camera, Bomtech, Korea) were used to evaluate skin tone improvement. SkinColorCatch was measured by contacting the probe vertically to the acne area of all the subjects, and the white LED light inside the probe was irradiated at 45 ° to detect the light reflected by the skin with an RGB color sensor. SkinColorCatch measurement consists of 5 factors: L *, a *, b *, melanin index, and erythema index. The L * value is brightness, the a * value is redness, and the b * value is Yellowness, melanin index indicates the amount of melanin present in the skin, and erythema index indicates the amount of skin erythema. As a measure of skin tone improvement of the test substance, L * value representing the brightness of the skin was used in the analysis, and it means that the skin tone improved as the measured value increased compared with before using the test substance. Video microscopes used the same investigator to measure acne in all subjects by 80 times in uniform illumination and in the same position for consistent imaging. Instrument measurements were taken before the test substance and after 4 weeks and after 5 weeks. The evaluation results are as shown in Tables 9 to 12 and FIG. 4.

As a result of analyzing skin tone improvement of acne area by using SkinColorCatch and video microscope, L * value indicating skin brightness increased 1.61% after 4 weeks and 2.14% after 5 weeks compared to before using test substance. Change. In addition, it was statistically significant after 4 weeks and 5 weeks after the use of the test substance (p <.01), and it was confirmed that the test substance helped to improve skin tone.

(Test 4) Evaluation of skin reactions

The investigator is responsible for erythema, edema, scaling, itching, stinging, burning, stiffness, and stinging that are abnormal skin at the test site. The results were prepared by observing whether or not skin abnormalities appeared and marking the grade. In addition, a questionnaire survey of skin adverse events was conducted.

No adverse reactions to allergic contact dermatitis or irritant contact dermatitis were observed after using the test substance in the subject.

Table 13 shows the skin adverse events reported by the test subjects.

In a survey of subjects, no specific skin reactions were observed.

Claims (13)

Vegetable microneedle powder obtained from Arkocaps phytosilica;
Moringa extract 0.9 to 1.1: sulfur white extract 0.4 to 0.6: rhubarb extract 0.4 to 0.6: tract extract 0.09 to 0.11: aloe vera extract 0.09 to 0.11: scrubber fruit extract complex consisting of 0.09 to 0.11 by weight ratio; And
At least one of Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF) as an active ingredient,
The content of the complex extract is contained 0.1 to 10% by weight based on the total weight of the composition,
The aloe vera extract and scrubber fruit extract is filled with aloe vera and scrubber fruit in a high-temperature vacuum steamer and heated the temperature of the heating vessel of the steamer to 250 ~ 300 ℃, the temperature of the heated steamer 30 Cooling to ~ 70 ℃ to take a vacuum pressure, and then the cosmetic composition for acne improvement characterized in that the extraction by heating the steamer for 24 hours. delete delete The method of claim 1,
The average length of the particles of the phytosilica is 100 to 300㎛, the width 10 to 20㎛ cosmetic composition. The method of claim 1,
The phytosilica is 0.01 to 7.0% by weight relative to the total weight of the composition. delete The method of claim 1,
The composite extract,
Water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, hexane and mixtures thereof Acne improvement cosmetic composition, characterized in that the extraction through the solvent extraction method using an extraction solvent. The method of claim 1,
The liver liver extract, yellow white extract, yellow lotus extract and spectral extract,
The shrine, the yellow white, the yellow lotus, and the crowd,
(a) a washing step;
(b) 20 to 50 minutes steaming at 80 to 100 ℃ and then hot air dried at 50 to 70 ℃ for 7 to 9 hours;
(c) secondary steaming at 80-100 ° C. for 20-50 minutes;
(d) lyophilized and milled;
(e) mixing the solvent to prepare a mixed solution;
(f) refining the mixed solution with an ultrasonic mill; And,
(g) after centrifugation, the supernatant is recovered and dried after filtration; acne improvement cosmetic composition characterized in that it is extracted. The method of claim 1,
Bacopamonniera extract 0.1 ~ 1.5% by weight, tea tree leaf oil 0.05 ~ 0.15% by weight, niacinamide 0.2 ~ 3% by weight based on the total weight of the composition. The method of claim 1,
Rosemary Leaf Extract, Green Tea Extract, Bergamot Leaf Extract, Lavender Flower Extract, Western Rose Flower Extract, Centella Extract, Rhododendron Extract, Golden Extract, Spanish Liquorice Root Extract, Chamomile Flower Extract, March Extract, Cider Extract, Mugwort Extract Acne improvement cosmetic composition further comprises a herbal extract consisting of one or more extracts selected from the group consisting of. delete The method of claim 1,
The composition is an anti-acne, anti-inflammatory, skin soothing, whitening, sebum secretion and skin rejuvenation promoting function, characterized in that the cosmetic composition for improving. The method according to any one of claims 1, 4 to 5, 7 to 10 and 12,
One or more formulated acne selected from the group consisting of softening cream, nourishing cream, nourishing cream, gel, ampoule, eye cream, cream, gel, cleansing cream, cleansing foam, cleansing water, pack, massage cream, essence, spray and powder Improvement cosmetic composition.

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