CN109276475A - One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof - Google Patents
One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof Download PDFInfo
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- CN109276475A CN109276475A CN201811380557.7A CN201811380557A CN109276475A CN 109276475 A CN109276475 A CN 109276475A CN 201811380557 A CN201811380557 A CN 201811380557A CN 109276475 A CN109276475 A CN 109276475A
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- bletilla polysaccharide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The present invention discloses one kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof, Chinese medicinal toothpaste containing bletilla polysaccharide is made of by weight percentage following components: bletilla polysaccharide 1~5%, rheum emodin 0.1~0.5%, glycerol 5~20%, Sorbitol solution 30~60%, saccharin sodium 0.1~0.5%, sodium carboxymethylcellulose 1~5%, friction-type silica 1 0~25%, thickening type silica 5~10%, lauryl sodium sulfate 1~5%, menthol 0.5~1%, sodium benzoate 0.1~0.5%, surplus are deionized water.The flavour of a drug of Chinese medicinal toothpaste containing bletilla polysaccharide prepared by the present invention are few and active constituent is clear, and safely and effectively, compliance is good；Rheum emodin and bletilla polysaccharide have synergistic effect, and the energy oral problems such as comprehensively solve gingivitis and its caused bleeding gums, canker sore reach treating both manifestation and root cause of disease.
Description
Technical field
The present invention relates to detergents and cosmetic technical fields, and in particular to one kind can reduce gingivitis, prevention and treatment bleeding gums
And canker sore, the Chinese medicinal toothpaste containing bletilla polysaccharide for promoting oral cavity wound healing and preparation method thereof.
Background technique
Toothpaste is oral cleaning amenities indispensable in people's daily life, and basic function is to clean tooth
Tooth, fresh breath, to keep oral cleaning.With consumer healthcare realize constantly promoted, it is desirable that toothpaste in addition to clean the teeth function it
Outside, also there is the miscellaneous function of certain prevention or treatment mouth disease.
Gingivitis refers to marginal gingiva, papillary gingiva, attachment gingival disease, is limited only to gingiva tissue without damaging in the group of gum deep layer
It knits, gingivitis is common one of the illness of the department of stomatology, often shows as bleeding gums, red and swollen, distending pain.Modern dentistry thinks,
The plaque accumulated on facing near gum edge is the initiation factor of gingivitis, the Streptococcus gathered in plaque
The pathogenic bacteria such as mutans and Streptococcus sobrinus can cause, aggravate gingivitis.Gingivitis is bleeding gums
Common cause, in addition to this, the shortage of vitamin, the local stimulation of dental calculus, improperly the mechanical stimulus such as teeth brushing way can be led
Cause bleeding gums.
In order to meet consumer demand, that is developed using safely and effectively Chinese medical extract as active constituent has anti-inflammatory
The toothpaste of hemostasia effect has had disclosure.Chinese patent " a kind of toothpaste with anti-inflammation hemostasia effect ", publication number
CN107468620A discloses the component and preparation method of toothpaste.The component of the toothpaste is by weight percentage are as follows: rubbing agent 30
~50%, wetting agent 20~40%, adhesive 0.5~1.5%, surfactant 2~3%, Chinese medicine composition 1~3%, peppermint
1~2%, saccharin 1~2%, deionized water 20~40%, the sum of each component are 100%；Chinese medicine composition is bletilla, dalbergia wood, passes through
The combination of crowd, subprostrate sophora, myrrh, Callicarpa bodinieri Levl., Chinese medicine composition are decocted using deionized water, after middle drug filtrate is cooling with other groups
Part is prepared into lotion of toothpaste.But Chinese patent CN107468620A has the following disadvantages: (1) Chinese medicine composition only discloses
The combination dosage of the 6 taste Chinese medicine such as bletilla does not disclose the 6 specific dosages of taste Chinese medicine, can not implement and not be inconsistent with drug matching theory；
(2) bletilla in Chinese medicine composition, rhizome of cyrtomium, subprostrate sophora, myrrh, 5 taste Chinese medicine bitter of Callicarpa bodinieri Levl., the toothpaste prepared using its decocting liquid
Lotion has bitter taste, can reduce the compliance of toothpaste；(3) Chinese medicine dalbergia wood main component is volatile oil, deionized water decocts 20~
30min dalbergia wood volatile oil can lose significantly, and Chinese medicine composition extracting mode is unreasonable；(4) Chinese medicine composition taste number is more, square in advance
Formula is simple, leads to Chinese medicine composition extract ingredient complicated composition, and active principle is indefinite, and subprostrate sophora is toxic, reduces
The safety of toothpaste.
Chinese patent " a kind of Chinese herbal toothpaste of antibacterial anti hemorrhagic ", publication number CN105534805A disclose 5 taste such as bletilla
The toothpaste of Chinese medical extract and suitable adjuvants preparation, the raw material of toothpaste percentage are as follows: Chinese herbal medicine 1%~4%, auxiliary agent
64.8%~66.8%, surplus be deionized water, the Chinese herbal medicine by bletilla, Radix Angelicae Sinensis, Radix Astragali, ginkgo leaf, radix paeoniae rubra by weight
For the composition of 3~7:2~7:2~5:4~7:5~8.Radix Angelicae Sinensis has effects that replenishing and activating blood in the patent, and ginkgo leaf has promoting blood circulation
The effect of stagnation resolvation, disagrees with hemostasia effect described in its patent, can not protrude the hemostasia effect of bletilla.Chinese patent
" a kind of Chinese herbal toothpaste made from bletilla striata ", publication number 101380285A disclose the toothpaste of the bletilla striata or bletilla polysaccharide and Paeonol preparation,
Paeonol haves the defects that stability is poor there are volatile, oxidizable decomposition in the patent；Paeonol is to plant pathogenetic bacteria
Do not act on, there is certain inhibiting effect to plant pathogenic fungi, and the pathogenic bacteria Streptococcusmutans of plaque and
Streptococcus sobrinus etc. is bacterium.
Summary of the invention
The present invention provides one kind can reduce gingivitis, prevention and treatment bleeding gums and canker sore, promotes oral cavity wound
The Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof of healing.
A kind of Chinese medicinal toothpaste containing bletilla polysaccharide, active constituent are bletilla polysaccharide and rheum emodin, bletilla polysaccharide weight for 1~
5%, weight is in terms of medicinal material weight；Rheum emodin weight is 0.1~0.5%.The dosage of bletilla polysaccharide is in terms of Bletilla striata medicinal materials.
Preferably, bletilla polysaccharide and rheum emodin are compound；Compound is that bletilla polysaccharide aqueous solution and rheum emodin are organic molten
Liquid is freeze-dried and obtains.
Preferably, bletilla polysaccharide weight is 3%, and rheum emodin weight is 0.3%.
Preferably, toothpaste also contains rubbing agent, adhesive, moisturizer, foaming agent, sweetener, preservative, aromatic, pH
Regulator, water.
Preferably, rubbing agent be friction-type silica, adhesive be thickening type silica and sodium carboxymethylcellulose,
Moisturizer is Sorbitol solution and glycerol, and Sorbitol solution is the aqueous solution of 69%~71% sorbierite, and foaming agent is dodecyl sulphur
Sour sodium, sweetener are saccharin sodium；Preservative is sodium benzoate, and aromatic is menthol, and pH adjusting agent is citric acid, and solvent is to go
Ionized water.
Preferably, toothpaste component and weight percent are as follows: bletilla polysaccharide 1~5%, rheum emodin 0.1~0.5%, glycerol 5~
20%, Sorbitol solution 30~60%, saccharin sodium 0.1~0.5%, sodium carboxymethylcellulose 1~5%, friction-type silica 10
~25%, thickening type silica 5~10%, lauryl sodium sulfate 1~5%, menthol 0.5~1%, sodium benzoate 0.1
~0.5%, surplus is deionized water.The pH value of Chinese medicinal toothpaste containing bletilla polysaccharide is 6~7.
Preferably, the weight ratio of friction-type silica and thickening type silica is (2~3): 1.
The present invention provides the preparation methods of the Chinese medicinal toothpaste containing bletilla polysaccharide comprising following steps:
(1) bletilla polysaccharide, rheum emodin, saccharin sodium, Sorbitol solution, glycerol, sodium benzoate, mixing are added into deionized water
Uniformly, liquid material A is obtained；
(2) sodium carboxymethylcellulose, friction-type silica, thickening type silica, lauryl sodium sulfate are mixed
Uniformly, powder material B is obtained；
(3) it is added powder material B into liquid material A, and with lemon acid for adjusting pH to 6~7, vacuum mixer is stirred until homogeneous, and is obtained
To mixing paste；
(4) menthol is added into mixing paste, continues to be stirred under vacuum to homogeneous transparent, packs to obtain the final product.
Preferably, bletilla polysaccharide and rheum emodin are compound in step (1), and compound is bletilla polysaccharide aqueous solution and rheum officinale
Plain organic solution is freeze-dried and obtains.
Wherein: the preparation method of bletilla polysaccharide is
The deionized water of 10~50 times of amounts is added in bletilla powder, and refluxing extraction 1~3 hour, ethyl alcohol is added after filtrate concentration,
Make its ethanol content 10~25% (V/V), stands centrifugation.Supernatant is taken, is concentrated, ethyl alcohol is added in concentrate, contains its ethyl alcohol
Amount be 85~90% (V/V), stand, sediment with plus deionized water redissolve after vacuum freeze drying.
The preparation method of bletilla polysaccharide is not limited to the above method, can also be using its other party such as ultrasonic extraction, extractions
Method extracts；Also existing commercially available bletilla polysaccharide can be used.
The preparation method of bletilla polysaccharide and rheum emodin compound: bletilla polysaccharide is redissolved with deionized water, and ethyl alcohol dissolution is added
Rheum emodin solution, then be freeze-dried.
The present invention provides the purposes of above-mentioned Chinese medicine dentifrice composition, the Chinese medicine tooth prepared by the present invention containing bletilla polysaccharide
Cream has the function of substantially reduced gingivitis, prevention and treatment bleeding gums and canker sore, promotes oral cavity wound healing.
In embodiments of the invention, the bletilla is orchid bletilla Bletilla striata (Thunb.)
Reichb.f. dry tuber.Summer, the excavation of two season of autumn, fibrous root is removed, is cleaned, set and boil or steam in boiling water to without the white heart, shine to half
It is dry, crust is removed, is dried.Its major function of bletilla is astringing to arrest bleeding, detumescence and promoting granulation, for spitting blood, is spitted blood, traumatic hemorrhage, sore
Ulcer pyogenic infections, chapped skin.Bletilla styptic activity ingredient is bletilla polysaccharide, and bletilla polysaccharide is by glucose and mannose by certain ratio
The neutral heteropolysaccharide. that example is polymerized.
Bletilla polysaccharide has apparent anastalsis, and mechanism of action is the activity for enhancing blood platelet factor III, shortens
Fibrin ferment generates the time, inhibits the activity of plasmase.Bletilla polysaccharide freeze-drying can form loose porous reticular structure,
Duct size is uniform and is evenly distributed, and can wrap up rheum emodin.And be dried under reduced pressure, the white of loose porous reticular structure can not be formed
And polysaccharide.It is used as Recombinant human epidermal growth factor carrier in bletilla polysaccharide, can remarkably promote surface of a wound superficial cell DNA's
Synthesis, improves the proliferative capacity of cell, shortens the healing time of wound, accelerate the healing of wound.Bletilla polysaccharide is used for toothpaste,
The symptoms such as bleeding gums, canker sore can be alleviated rapidly.
Rheum emodin has the bacteriostasis of wide spectrum, and bacteriostasis is stronger, to intraoral Streptococcusmutans
Significantly inhibited with pathogenic bacteria such as Streptococcus sobrinus it is used, while to streptococcus mutans, grignard streptococcus, blood
Liquid streptococcus, micrococcus scarlatinae, staphylococcus aureus, actinomyces significantly inhibit effect, can inhibit the shape of plaque
At prevention or treatment gingivitis.Rheum emodin has the characteristic of distillation, and bletilla polysaccharide is rich sticky, and freeze-drying can be formed
Rheum emodin can be embedded the reduction of composition caused by wherein effectivelying prevent distilling because of rheum emodin by loose porous reticular structure
With the reduction of effect.
Gingivitis often results in bleeding gums, and rheum emodin can effectively prevent or treat gingivitis, and bletilla polysaccharide can effectively stop blooding
Healing with wound is promoted, and can be reduced the loss of rheum emodin and improves its fungistatic effect, have synergistic effect.Therefore by rheum officinale
Element compounds obtained toothpaste with bletilla polysaccharide and can complement each other, and can inhibit the formation of plaque and alleviate gum to go out
Blood, canker sore achieve the effect that treating both manifestation and root cause of disease, the oral problems such as comprehensively solve gingivitis and its caused bleeding.
For the pH of toothpaste prepared by the present invention between 6~7, pH adjusting agent used is citric acid.Citric acid is in the present invention
In play a key role: (1) weak acid property retention active constituent rheum emodin have good inhibitory effect；(2) human saliva
PH be 6.6~7.1, be in neutrality or faintly acid, lemon acid for adjusting pH to 6~7 coincide substantially with the pH of human saliva, can have
Physiology of oral cavity pH environment is kept, the biology for guaranteeing mucin in oral cavity, sticking polysaccharide, ptyalin, lysozyme, immunoglobulin
Activity especially can guarantee that there is lysozyme good bactericidal effect (can be stabilized in acid medium, in alkaline medium in oral cavity
Easy in inactivation).
Friction-type silica and thickening type silica are bought from DENTSIL company, wherein friction-type silica
Make rubbing agent, thickening type silica makees thickener.Friction-type silica frictional force is stronger, for removing tooth stain, whitening；Thickening
Type silica mainly plays thickening power, and the transparency that can not only improve toothpaste (connects with the index of refraction of friction-type silica
Closely), make toothpaste entirety crystal clear, it is more beautiful, while can be reduced sodium carboxymethylcellulose it is filling when generate wire drawing phenomenon, side
Just filling.
Menthol is aromatic, and menthol has effects that fresh breath, refreshes the mind.
Compared with prior art, the present invention having the following beneficial effects:
1. toothpaste flavour of a drug prepared by the present invention are few and active constituent is clear, it is ensured that the stabilization of effect and the safety used
Property, can avoid kinds of traditional Chinese medicines extract poor taste the drawbacks of, improve compliance；Furthermore bletilla polysaccharide and rheum emodin are natural plants
Extraction obtains, abundance and renewable, environmentally protective.
2. rheum emodin and bletilla polysaccharide have synergistic effect, the rich sticking loose porous reticular structure energy of bletilla polysaccharide
Rheum emodin is embedded, the reduction of rheum emodin and the reduction of effect are effectively prevent；Rheum emodin can effectively prevent or treat gingivitis, bletilla
Polysaccharide effectively can stop blooding and promote the healing of wound, can the oral problems such as comprehensively solve gingivitis and its caused bleeding,
Reach treating both manifestation and root cause of disease.
3. Chinese medicinal toothpaste containing bletilla polysaccharide prepared by the present invention has suitable pH value, close with human saliva pH, can protect
Physiology of oral cavity pH environment is held, can guarantee that lysozyme has good bactericidal effect in oral cavity；The weak acid property retention rheum officinale of appropriateness
Plain bacteriostatic activity does not decline.
4. friction-type silica and the collaboration of thickening type silica use, the transparency of toothpaste can not only be improved, make it
Character transparent and homogeneous；And it is avoided that generation wire drawing phenomenon when sodium carboxymethylcellulose is filling, be conducive to filling.
Specific embodiment
Combined with specific embodiments below, the Chinese medicinal toothpaste containing bletilla polysaccharide that the present invention will be described in detail, but guarantor of the invention
Range is protected, it is not limited to this.In following examples, related percentage is with weight percent unless otherwise indicated
It calculates.
Embodiment
Embodiment 1
Bletilla polysaccharide 2%, rheum emodin 0.5%, glycerol 20%, Sorbitol solution 30%, saccharin sodium 0.3%, carboxymethyl cellulose
Plain sodium 1.5%, friction-type silica 25%, thickening type silica 1 0%, lauryl sodium sulfate 2%, menthol
0.6%, sodium benzoate 0.5%, deionized water 7.6% is weight percentage.
Preparation method:
(1) by 2 parts by weight bletilla polysaccharides, 0.5 parts by weight rheum emodin, 0.3 parts by weight saccharin sodium, 30 parts by weight sorbierites
Liquid, 20 parts by weight of glycerin, 0.5 parts by weight sodium are sufficiently dissolved with 7.6 parts by weight of deionized water, are uniformly mixed, are obtained liquid
Expect A；
(2) by 1.5 parts by weight sodium carboxymethylcelluloses, 25 parts by weight of friction type silica, 10 parts by weight thickening types two
Silica, 2 parts by weight lauryl sodium sulfate are uniformly mixed, and obtain powder material B；
(3) it is added powder material B into liquid material A, and with lemon acid for adjusting pH to 6.8, vacuum mixer is stirred until homogeneous, and is obtained
Mixing paste.
(4) be added 0.6 parts by weight menthol into mixing paste, be stirred under vacuum to uniformly it is translucent to obtain the final product.
Embodiment 2
Bletilla polysaccharide 3%, rheum emodin 0.3%, glycerol 15%, Sorbitol solution 45%, saccharin sodium 0.3%, carboxymethyl cellulose
Plain sodium 1%, friction-type silica 1 5%, thickening type silica 5%, lauryl sodium sulfate 5%, menthol 1%, benzene first
Sour sodium 0.3%, deionized water 9.1% are weight percentage.
Preparation method:
(1) by 3 parts by weight bletilla polysaccharides, 0.3 parts by weight rheum emodin, 0.3 parts by weight saccharin sodium, 45 parts by weight sorbierites
Liquid, 15 parts by weight of glycerin, 0.3 parts by weight sodium are sufficiently dissolved with 9.1 parts by weight of deionized water, are uniformly mixed, are obtained liquid
Expect A；
(2) by 1 parts by weight sodium carboxymethylcellulose, 15 parts by weight of friction type silica, 5 parts by weight thickening type titanium dioxides
Silicon, 5 parts by weight lauryl sodium sulfate are uniformly mixed, and obtain powder material B；
(3) it is added powder material B into liquid material A, and with lemon acid for adjusting pH to 6.6, vacuum mixer is stirred until homogeneous, and is obtained
Mixing paste.
(4) be added 1 parts by weight menthol into mixing paste, be stirred under vacuum to uniformly it is translucent to obtain the final product.
Embodiment 3
Bletilla polysaccharide 1%, rheum emodin 0.1%, glycerol 10%, Sorbitol solution 50%, saccharin sodium 0.5%, carboxymethyl cellulose
Plain sodium 5%, friction-type silica 1 8%, thickening type silica 8%, lauryl sodium sulfate 4%, menthol 0.8%, benzene
Sodium formate 0.1%, deionized water 2.5%, is weight percentage.
Preparation method:
(1) by bletilla polysaccharide and rheum emodin compound (1 parts by weight bletilla polysaccharide, 0.1 parts by weight rheum emodin), 0.5 weight
Part saccharin sodium, 50 parts by weight Sorbitol solutions, 10 parts by weight of glycerin, 0.1 parts by weight sodium are filled with 2.5 parts by weight of deionized water
Divide dissolution, is uniformly mixed, obtains liquid material A；
(2) by 5 parts by weight sodium carboxymethylcelluloses, 18 parts by weight of friction type silica, 8 parts by weight thickening type titanium dioxides
Silicon, 4 parts by weight lauryl sodium sulfate are uniformly mixed, and obtain powder material B；
(3) it is added powder material B into liquid material A, and with lemon acid for adjusting pH to 6.7, vacuum mixer is stirred until homogeneous, and is obtained
Mixing paste.
(4) be added 0.8 parts by weight menthol into mixing paste, be stirred under vacuum to uniformly it is translucent to obtain the final product.
Embodiment 4
Bletilla polysaccharide 5%, rheum emodin 0.1%, glycerol 5%, Sorbitol solution 60%, saccharin sodium 0.1%, carboxymethyl cellulose
Sodium 3%, friction-type silica 1 0%, thickening type silica 5%, lauryl sodium sulfate 1%, menthol 0.5%, benzene first
Sour sodium 0.3%, deionized water 10% are weight percentage.
Preparation method:
(1) by 5 parts by weight bletilla polysaccharides, 0.1 parts by weight rheum emodin, 0.1 parts by weight saccharin sodium, 60 parts by weight sorbierites
Liquid, 5 parts by weight of glycerin, 0.3 parts by weight sodium are sufficiently dissolved with 10 parts by weight of deionized water, are uniformly mixed, are obtained liquid material
A；
(2) by 3 parts by weight sodium carboxymethylcelluloses, 10 parts by weight of friction type silica, 5 parts by weight thickening type titanium dioxides
Silicon, 1 parts by weight lauryl sodium sulfate are uniformly mixed, and obtain powder material B；
(3) it is added powder material B into liquid material A, and with lemon acid for adjusting pH to 6.9, vacuum mixer is stirred until homogeneous, and is obtained
Mixing paste.
(4) be added 0.5 parts by weight menthol into mixing paste, be stirred under vacuum to uniformly it is translucent to obtain the final product.
Embodiment 5
Bletilla polysaccharide 4%, rheum emodin 0.3%, glycerol 15%, Sorbitol solution 40%, saccharin sodium 0.2%, carboxymethyl cellulose
Plain sodium 2%, friction-type silica 20%, thickening type silica 7%, lauryl sodium sulfate 3%, menthol 0.6%, benzene
Sodium formate 0.2%, deionized water 7.7%, is weight percentage.
Preparation method:
(1) by bletilla polysaccharide and rheum emodin compound (4 parts by weight bletilla polysaccharides, 0.3 parts by weight rheum emodin), 0.2 weight
Part saccharin sodium, 40 parts by weight Sorbitol solutions, 15 parts by weight of glycerin, 0.2 parts by weight sodium are filled with 7.7 parts by weight of deionized water
Divide dissolution, is uniformly mixed, obtains liquid material A；
(2) by 2 parts by weight sodium carboxymethylcelluloses, 20 parts by weight of friction type silica, 7 parts by weight thickening type titanium dioxides
Silicon, 2 parts by weight lauryl sodium sulfate are uniformly mixed, and obtain powder material B；
(3) it is added powder material B into liquid material A, and with lemon acid for adjusting pH to 6.8, vacuum mixer is stirred until homogeneous, and is obtained
Mixing paste.
(4) be added 0.6 parts by weight menthol into mixing paste, be stirred under vacuum to uniformly it is translucent to obtain the final product.Comparative example 1
Rheum emodin 0.5%, glycerol 20%, Sorbitol solution 30%, saccharin sodium 0.3%, sodium carboxymethylcellulose 1.5% rub
Wiping type silica 25%, thickening type silica 1 0%, lauryl sodium sulfate 2%, menthol 0.6%, sodium benzoate
0.5%, deionized water 9.6% is weight percentage.
Preparation method:
(1) by 0.5 parts by weight rheum emodin, 0.3 parts by weight saccharin sodium, 30 parts by weight Sorbitol solutions, 20 parts by weight of glycerin,
0.5 parts by weight sodium is sufficiently dissolved with 9.6 parts by weight of deionized water, is uniformly mixed, is obtained liquid material A；
(2) by 1.5 parts by weight sodium carboxymethylcelluloses, 25 parts by weight of friction type silica, 10 parts by weight thickening types two
Silica, 2 parts by weight lauryl sodium sulfate are uniformly mixed, and obtain powder material B；
(3) it is added powder material B into liquid material A, and with lemon acid for adjusting pH to 6.8, vacuum mixer is stirred until homogeneous, and is obtained
Mixing paste.
(4) be added 0.6 parts by weight menthol into mixing paste, be stirred under vacuum to uniformly it is translucent to obtain the final product.Comparative example 2
Bletilla polysaccharide 2%, rheum emodin 0.5%, glycerol 20%, Sorbitol solution 30%, saccharin sodium 0.3%, carboxymethyl cellulose
Plain sodium 1.5%, friction-type silica 25%, thickening type silica 1 0%, lauryl sodium sulfate 2%, menthol
0.6%, sodium benzoate 0.5%, deionized water 7.6% is weight percentage.
Preparation method:
(1) by 2 parts by weight bletilla polysaccharides, 0.5 parts by weight rheum emodin, 0.3 parts by weight saccharin sodium, 30 parts by weight sorbierites
Liquid, 20 parts by weight of glycerin, 0.5 parts by weight sodium are sufficiently dissolved with 7.6 parts by weight of deionized water, are uniformly mixed, are obtained liquid
Expect A；
(2) by 1.5 parts by weight sodium carboxymethylcelluloses, 25 parts by weight of friction type silica, 10 parts by weight thickening types two
Silica, 2 parts by weight lauryl sodium sulfate are uniformly mixed, and obtain powder material B；
(3) powder material B is added into liquid material A, vacuum mixer is stirred until homogeneous, and obtains mixing paste.
(4) be added 0.6 parts by weight menthol into mixing paste, be stirred under vacuum to uniformly it is translucent to obtain the final product.Comparative example 3
Containing bletilla polysaccharide, the component of rheum officinale dentifrice and weight percent are as follows: bletilla polysaccharide 4%, rheum emodin 0.3% are sweet
Oil 15%, Sorbitol solution 40%, saccharin sodium 0.2%, sodium carboxymethylcellulose 2%, friction-type silica 20%, dodecyl
Sodium sulphate 3%, menthol 0.6%, sodium benzoate 0.2%, deionized water 14.7%.
Preparation method:
(1) by 4 parts by weight bletilla polysaccharides, 0.2 parts by weight rheum emodin, 0.2 parts by weight saccharin sodium, 40 parts by weight sorbierites
Liquid, 15 parts by weight of glycerin, 0.2 parts by weight sodium are sufficiently dissolved with 14.7 parts by weight of deionized water, are uniformly mixed, are obtained liquid
Expect A；
(2) by 2 parts by weight sodium carboxymethylcelluloses, 20 parts by weight of friction type silica, 2 parts by weight dodecyl sulphates
Sodium is uniformly mixed, and obtains powder material B；
(3) it is added powder material B into liquid material A, and with lemon acid for adjusting pH to 6.8, vacuum mixer is stirred until homogeneous, and is obtained
Mixing paste.
(4) be added 0.6 parts by weight menthol into mixing paste, be stirred under vacuum to uniformly it is translucent to obtain the final product.Experimental example
The pharmaceutical research of 1 bletilla polysaccharide of experimental example
Given the test agent: bletilla polysaccharide is configured to the solution for standby of respective concentration with deionized water before use.
1, to the anastalsis of mouse liver local woanded surface damage
Healthy female KM kind mouse 20 are bought by Hubei Province Animal Experimental Study center, 18~22g of weight, mouse presses body
It is randomly divided into four groups, i.e. blank control group (deionized water), bletilla polysaccharide low dose group (1% bletilla polysaccharide solution), bletilla again
Polysaccharide middle dose group (2% bletilla polysaccharide solution) and bletilla polysaccharide high dose group (3% bletilla polysaccharide solution).With chloraldurate fiber crops
After liquor-saturated mouse, abdomen is opened, exposure liver cuts off one piece in liver surface with scissors and is about 1cm, the tissue of wide about 0.2cm will be coated with
The gauze covering of given the test agent is got on, primary every 15s observation, is recorded bleeding stopping period, is recorded and carry out statistics t inspection, ties
Fruit is shown in Table 4.
Haemostatic effect (mean ± SD) of 4 bletilla polysaccharide of table to KM mouse liver local woanded surface bleeding due to trauma
| Group | Experimental animal number | Bleeding stopping period (s) |
| Blank group | 5 | 168.6±22.2 |
| Low dose group | 5 | 108.4±13.5* |
| Middle dose group | 5 | 86.2±4.5* |
| High dose group | 5 | 55.0±5.1* |
Note: compared with blank group, * P < 0.05.
The experimental results showed that bletilla polysaccharide has apparent haemostatic effect, bletilla to mouse liver local woanded surface bleeding due to trauma
Polysaccharide can substantially reduce the animals surface damage bleeding time.
2, to the anastalsis of mouse docking
Healthy female KM kind mouse 20 are bought by Hubei Province Animal Experimental Study center, 18~22g of weight, mouse presses body
It is randomly divided into four groups, i.e. blank control group (deionized water) again, bletilla polysaccharide low dose group (0.2mg/g), agent in bletilla polysaccharide
Amount group (0.4mg/g) and bletilla polysaccharide high dose group (0.8mg/g).0.2ml/10g is raised in every group of filling, and one time a day, continuous fill raises 7
It.After last fills feeding 1 hour, mouse is fixed, away from being cut at tail point 5mm, blood is dipped in filter paper, dips within every 15 seconds once, with filter
There is no the time of bloodstain to be determined as the mouse bleeding time on paper, records and carry out statistics t inspection, the results are shown in Table 5.
Haemostatic effect (mean ± SD) of 5 bletilla polysaccharide of table to the docking bleeding of KM mouse
| Group | Experimental animal number | Bleeding stopping period |
| Blank group | 5 | 345.0±49.9 |
| Low dose group | 5 | 177.6±14.8* |
| Middle dose group | 5 | 115.5±8.6* |
| High dose group | 5 | 93.0±7.3* |
Note: compared with blank group, * P < 0.05.
Test result shows that bletilla polysaccharide has apparent haemostatic effect to mouse docking bleeding, and bletilla polysaccharide can be significant
Reduce animal tail bleeding times.
It is examined by statistics t, by each group of data compared with blank group, calculated result P < 0,05, that is, think and blank group
With significant difference compared with each group, that is, there is apparent haemostatic effect.The symptom of canker sore first is that bleeding gums, because
The effect of this hemostasis, can mitigate bleeding gums and canker sore, the healing for promoting oral cavity wound.
Therefore, it is possible to judge that a kind of Chinese medicinal toothpaste proposed by the invention has obvious substantially reduced gingivitis, prevention and treatment
Bleeding gums and canker sore, the effect for promoting oral cavity wound healing.
Test example 2
Sample prepared by the sample and comparative example 1~2 for taking the embodiment of the present invention 1~5 to prepare carries out pH value measurement, and will be real
It applies example and comparative example to place 3 months under the conditions of 25 ± 2 DEG C, then using HPLC method measurement emodin content and uses paper
As a result piece diffusion method see the table below according to inhibition zone size measurement bacteriostatic activity.
Test result shows that in amount ranges, rheum emodin has significant fungistatic effect, can inhibit the formation of plaque,
Prevention or treatment gingivitis.
Test example 3
Sample prepared by the sample and comparative example 3 for taking the embodiment of the present invention 4~5 to prepare carries out the investigation of character and characteristic,
As a result it see the table below.
| Character | Wire drawing | |
| Embodiment 4 | It is transparent | Without wire drawing phenomenon |
| Embodiment 5 | It is transparent | Without wire drawing phenomenon |
| Comparative example 3 | Poor transparency | There are wire drawing phenomenons |
Claims (10)
1. a kind of Chinese medicinal toothpaste containing bletilla polysaccharide, which is characterized in that active constituent is bletilla polysaccharide and rheum emodin, and the bletilla is more
Sugar weight is 1~5%, and weight is in terms of medicinal material weight；The rheum emodin weight is 0.1~0.5%.
2. Chinese medicinal toothpaste containing bletilla polysaccharide according to claim 1, which is characterized in that the bletilla polysaccharide is with rheum emodin
Compound, the compound are that bletilla polysaccharide aqueous solution and rheum emodin organic solution are freeze-dried and obtain.
3. Chinese medicinal toothpaste containing bletilla polysaccharide according to claim 1, which is characterized in that the bletilla polysaccharide weight is 3%,
The rheum emodin weight is 0.3%.
4. Chinese medicinal toothpaste containing bletilla polysaccharide according to claim 1, which is characterized in that also contain rubbing agent, adhesive, guarantor
Humectant, foaming agent, sweetener, preservative, aromatic, pH adjusting agent, solvent.
5. Chinese medicinal toothpaste containing bletilla polysaccharide according to claim 4, which is characterized in that the rubbing agent is friction-type dioxy
SiClx, described adhesive are thickening type silica and sodium carboxymethylcellulose, and the moisturizer is Sorbitol solution and glycerol, institute
The aqueous solution that Sorbitol solution is 69%~71% sorbierite is stated, the foaming agent is lauryl sodium sulfate, and the sweetener is
Saccharin sodium, the preservative are sodium benzoate, and the aromatic is menthol, and the pH adjusting agent is citric acid, the solvent
For deionized water.
6. Chinese medicinal toothpaste containing bletilla polysaccharide according to claim 5, which is characterized in that the Chinese medicinal toothpaste containing bletilla polysaccharide
The weight percent of component are as follows: bletilla polysaccharide 1~5%, rheum emodin 0.1~0.5%, glycerol 5~20%, Sorbitol solution 30~
60%, saccharin sodium 0.1~0.5%, sodium carboxymethylcellulose 1~5%, friction-type silica 1 0~25%, thickening type dioxy
SiClx 5~10%, lauryl sodium sulfate 1~5%, menthol 0.5~1%, sodium benzoate 0.1~0.5%, surplus be go from
Sub- water；
The pH value of Chinese medicinal toothpaste containing bletilla polysaccharide is 6~7.
7. Chinese medicinal toothpaste containing bletilla polysaccharide according to claim 6, which is characterized in that the friction-type silica and increasing
The weight ratio of thick type silica is (2~3): 1.
8. a kind of preparation method of Chinese medicinal toothpaste containing bletilla polysaccharide, which comprises the following steps:
(1) bletilla polysaccharide, rheum emodin, saccharin sodium, Sorbitol solution, glycerol, sodium benzoate are added into deionized water, mixing is equal
It is even, obtain liquid material A；
(2) sodium carboxymethylcellulose, friction-type silica, thickening type silica, lauryl sodium sulfate are uniformly mixed,
Obtain powder material B；
(3) it is added powder material B into the liquid material A, and with lemon acid for adjusting pH to 6~7, vacuum mixer is stirred until homogeneous, and is obtained
To mixing paste；
(4) menthol is added into the mixing paste, continues to be stirred under vacuum to homogeneous transparent, pack to obtain the final product.
9. preparation method according to claim 8, which is characterized in that bletilla polysaccharide described in step (1) is with rheum emodin
Compound, the compound are that bletilla polysaccharide aqueous solution and rheum emodin organic solution are freeze-dried and obtain.
10. any Chinese medicinal toothpaste is for mitigating gingivitis, prevention and treatment bleeding gums and oral cavity according to claim 1~7
Ulcer, the purposes for promoting oral cavity wound healing.
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| CN117323241A (en) * | 2023-10-24 | 2024-01-02 | 金三江(肇庆)硅材料股份有限公司 | Silica particles for oral cavity as well as preparation method and application thereof |
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