CN109549948A - The application of root bark of tree peony polysaccharide, the toothpaste containing root bark of tree peony polysaccharide and preparation method thereof - Google Patents
The application of root bark of tree peony polysaccharide, the toothpaste containing root bark of tree peony polysaccharide and preparation method thereof Download PDFInfo
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- CN109549948A CN109549948A CN201910094609.2A CN201910094609A CN109549948A CN 109549948 A CN109549948 A CN 109549948A CN 201910094609 A CN201910094609 A CN 201910094609A CN 109549948 A CN109549948 A CN 109549948A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- Oral & Maxillofacial Surgery (AREA)
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Abstract
The present invention relates to the application of root bark of tree peony polysaccharide, toothpaste and preparation method thereof, wherein the toothpaste containing root bark of tree peony polysaccharide, including root bark of tree peony polysaccharide, by weight percentage, the root bark of tree peony polysaccharide accounts for the 0.2 ~ 0.5% of toothpaste total weight；It further include the menthol for accounting for toothpaste total weight 0.5 ~ 1%；The toothpaste base-material includes following raw material by weight percentage: accounting for the rubbing agent of toothpaste total weight 25 ~ 60%；Account for the wetting agent of toothpaste total weight 10 ~ 55%；Account for the adhesive of toothpaste total weight 0.3 ~ 1.5%；Account for the foaming agent of toothpaste total weight 1.5 ~ 2.5%；Account for 1.5 ~ 3.0% stabilizer of toothpaste total weight；Deionized water surplus.The present invention can it is anti-inflammatory it is antibacterial, go halitosis, repair canker sore, for effective component root bark of tree peony polysaccharide origin in cortex moutan, ingredient is natural.
Description
Technical field
The invention belongs to application, the toothpaste containing root bark of tree peony polysaccharide and its preparations of field of toothpaste more particularly to root bark of tree peony polysaccharide
Method.
Background technique
Canker sore is a kind of common mouth disease, caused by virus or bacterium, generally by streptococcus, golden yellow grape
Caused by coccus, Escherichia coli, it is a kind of oral mucosa limitation ulcerative lesions with the characteristics of cyclical recurrent, can sends out
Life is at any position of oral mucosa.It is common with the mucous membrane of the lip in oral cavity, cheek, soft palate or gums etc., occur single or more
A round or ellipse ulcer to differ in size, surface cover greyish white or yellow pseudomembrane, concavity, and clear border is around glued
Film is red and micro- swollen, and ulcer part cusalgia is obvious, has periodicity, the feature of recurrent, self limiting.Serious canker sore patient
It is also possible to complication such as swelling and aching of gum, bleeding gums.
The prevention and treatment of canker sore is mainly directly applied using chemicals at present and is used for ulcer surface, such as: tetrahydro
Folic acid, Bingpeng San, metronidazole, ketoconazole etc., when use, are easily swallowed and cause other adverse reactions, and it is chemicals pair
The irritation of the surface of a wound is bigger；
Toothpaste is requirement in daily life, there is very long history.With the continuous development of science and technology, technique fills
Standby to continuously improve and perfect, various types of toothpaste are come out one after another, and the quality and grade of product is continuously improved, present toothpaste product
Kind develops into great variety of goods by single clean type toothpaste, vdiverse in function.Find a kind of natural life that can prevent and treat ulcer
Object ingredient, and be applied in toothpaste, seem most important in canker sore for repairing.
Summary of the invention
It is an object of the invention to overcome the deficiencies of existing technologies, the application of root bark of tree peony polysaccharide is provided, containing root bark of tree peony polysaccharide
Toothpaste and preparation method thereof.
To achieve the goals above, the technical solution adopted by the present invention is as follows:
Technical solution one:
Application of the root bark of tree peony polysaccharide as drug activity ingredient in preparation prevention and treatment stomatocace medicine.
Technical solution two:
Root bark of tree peony polysaccharide is preparing the application in anti-treating dental ulcer toothpaste as drug activity ingredient.
Technical solution three:
A kind of toothpaste containing root bark of tree peony polysaccharide, including root bark of tree peony polysaccharide, by weight percentage, the root bark of tree peony polysaccharide account for toothpaste
The 0.2~0.5% of total weight；
It further, by weight percentage, further include the menthol for accounting for toothpaste total weight 0.5~1%.
Further, by weight percentage, further include following raw material: accounting for the friction of toothpaste total weight 25~60%
Agent；Account for the wetting agent of toothpaste total weight 10~55%；Account for the adhesive of toothpaste total weight 0.3~1.5%；Account for toothpaste total weight
1.5~2.5% foaming agent；Account for the stabilizer of toothpaste total weight 1.5~3.0%；Deionized water surplus.
Further, the rubbing agent include dicalcium phosphate dihydrate, hydrated silica, calcium carbonate, in aluminium hydroxide
One or more；
The wetting agent includes one or more of glycerol, propylene glycol, sorbierite；
The foaming agent includes one or more of laruyl alcohol sodium sulfovinate, sodium N-lauroyl sarcosinate；
Described adhesive includes sodium carboxymethylcellulose, carboxyethyl cellulose, xanthan gum, melon Lovell glue, one in carragheen
Kind is several；
The stabilizer uses tetrasodium pyrophosphate.
Technical solution four:
A kind of preparation method of the toothpaste containing root bark of tree peony polysaccharide, specifically includes the following steps:
Step 1: weighing each raw material in proportion, after root bark of tree peony polysaccharide deionized water dissolving, obtains root bark of tree peony polysaccharide solution, to
With；
Step 2: rubbing agent, foaming agent, adhesive, wetting agent and other auxiliary materials are added sequentially to made from step 1
Root bark of tree peony polysaccharide solution selectively adds menthol after stirring 10min, continues stirring to mixing well, cream is made in grinding, degassing
Body to get.
Technical solution five:
A kind of toothpaste containing root bark of tree peony polysaccharide is repairing the application in canker sore.
Technical solution six:
A kind of toothpaste containing root bark of tree peony polysaccharide it is anti-inflammatory it is antibacterial, go halitosis, repair the application in canker sore.
Compared with prior art, advantages of the present invention are as follows:
Root bark of tree peony polysaccharide is the pharmacological active substance that extracts in cortex moutan, can inhibiting bacteria and diminishing inflammation, promote ulcer healing, and disappear
Scorching, analgesic, fresh breath menthol be used cooperatively, play the role of jointly it is anti-inflammatory it is antibacterial, go halitosis, repair canker sore.
Specific embodiment
Further details of narration is carried out to the present invention with reference to embodiments.
The preparation method of root bark of tree peony polysaccharide, specifically includes the following steps:
Step 1 is extracted: it weighs cortex moutan, after ultramicro grinding, crosses 200 meshes, add distilled water by 1:20-30 mass fraction,
60min is impregnated, heating boils and keeps 30min, 10000rpm to be centrifuged 10min, take supernatant, in triplicate, merge supernatant,
The dehydrated alcohol that 5 times of volumes are added is centrifuged 5min in precipitation at room temperature 12h, 10000rpm, collects precipitating, volatilizes to solvent, collects
Solid obtains Thick many candies；
Step 2, Thick many candies take off albumen: will be configured to the aqueous solution of 100mg/ml after Thick many candies plus distilled water dissolution, be added
The chloroform of 1/5 volume 5:1v/v: n-butanol acutely vibrates, and 4000rpm is centrifuged 20min, abandons precipitating, repeatedly until centrifugation
Solvent interface is without precipitating afterwards；
Step 3, Thick many candies dephenolize: the Thick many candies after taking de- albumen are added isometric acetone soln, shake well,
4000rpm is centrifuged 20min, collects precipitating and (detects through phenol-dense sulphuric acid method, the mass content of root bark of tree peony polysaccharide to get root bark of tree peony polysaccharide
More than or equal to 80%)；Wherein, the acetone is anhydrous propanone.
Embodiment 1
A kind of toothpaste containing root bark of tree peony polysaccharide, including following raw material based on percent by weight:
Root bark of tree peony polysaccharide 0.35%；
Menthol 0.75%；
Rubbing agent: two water object 45% of calcium monohydrogen phosphate；
Wetting agent: glycerol 13%；
Wetting agent: sorbierite 19%
Adhesive: sodium carboxymethylcellulose 0.6%；
Foaming agent: laruyl alcohol sodium sulfovinate 2.0%；
Stabilizer: tetrasodium pyrophosphate 2.5%；
Deionized water: 16.8%.
Preparation method are as follows:
Step 1: weighing each raw material in proportion, to after root bark of tree peony polysaccharide deionized water dissolving, obtains root bark of tree peony polysaccharide solution, to
With；
Step 2: by rubbing agent, foaming agent, adhesive, wetting agent and other auxiliary material stabilizers, it is added sequentially to step 1
After stirring 10min, menthol is added in root bark of tree peony polysaccharide solution obtained, continues stirring to mixing well, cream is made in grinding, degassing
Body to get；The revolving speed of the stirring is 1000r/min.
Embodiment 2
Root bark of tree peony polysaccharide 0.2%；
Menthol 0.5%；
Rubbing agent: two water object 45% of calcium monohydrogen phosphate；
Wetting agent: glycerol 13%；
Wetting agent: sorbierite 19%
Adhesive: sodium carboxymethylcellulose 0.6%；
Foaming agent: laruyl alcohol sodium sulfovinate 2.0%；
Stabilizer: tetrasodium pyrophosphate 2.5%；
Deionized water: 17.2%.
Preparation method are as follows: with embodiment 1；
Embodiment 3
Root bark of tree peony polysaccharide 0.5%；
Menthol 1%；
Rubbing agent: two water object 45% of calcium monohydrogen phosphate；
Wetting agent: glycerol 13%；
Wetting agent: sorbierite 19%
Adhesive: sodium carboxymethylcellulose 0.6%；
Foaming agent: laruyl alcohol sodium sulfovinate 2.0%；
Stabilizer: tetrasodium pyrophosphate 2.5%；
Deionized water: 16.4%.
Preparation method are as follows: with embodiment 1；
Embodiment 4
A kind of toothpaste containing root bark of tree peony polysaccharide, including following raw material based on percent by weight:
Root bark of tree peony polysaccharide 0.35%；
Rubbing agent: two water object 45% of calcium monohydrogen phosphate；
Wetting agent: glycerol 13%；
Wetting agent: sorbierite 19%
Adhesive: sodium carboxymethylcellulose 0.6%；
Foaming agent: laruyl alcohol sodium sulfovinate 2.0%；
Stabilizer: tetrasodium pyrophosphate 2.5%；
Deionized water: 17.55%.
Preparation method are as follows:
Step 1: weighing each raw material in proportion, after root bark of tree peony polysaccharide deionized water dissolving, obtains root bark of tree peony polysaccharide solution, to
With；
Step 2: by rubbing agent, foaming agent, adhesive, wetting agent and other auxiliary material stabilizers, it is added sequentially to step 1
In root bark of tree peony polysaccharide solution obtained, stirring is persistently stirred with 1000r/min revolving speed to mixing well, lotion is made in grinding, degassing,
To obtain the final product.
Comparative example 1
A kind of toothpaste, including following raw material based on percent by weight:
Menthol 0.5%；
Rubbing agent: two water object 45% of calcium monohydrogen phosphate；
Wetting agent: glycerol 13%；
Wetting agent: sorbierite 19%
Adhesive: sodium carboxymethylcellulose 0.6%；
Foaming agent: laruyl alcohol sodium sulfovinate 2.0%；
Stabilizer: tetrasodium pyrophosphate 2.5%；
Deionized water: 17.4%.
The Chinese medical extract the preparation method comprises the following steps: with embodiment 1；
Preparation method are as follows:
Rubbing agent, foaming agent, adhesive, wetting agent and other auxiliary material stabilizers are sequentially added in deionized water, stir
After 10min, menthol is added, continues stirring to mixing well, grinding, degassing be made lotion to get；The revolving speed of the stirring is
1000r/min。
Comparative example 2
A kind of toothpaste, including following raw material based on percent by weight:
Rubbing agent: two water object 45% of calcium monohydrogen phosphate；
Wetting agent: glycerol 13%；
Wetting agent: sorbierite 19%
Adhesive: sodium carboxymethylcellulose 0.6%；
Foaming agent: laruyl alcohol sodium sulfovinate 2.0%；
Stabilizer: tetrasodium pyrophosphate 2.5%；
Deionized water: 17.9%.
Preparation method are as follows:
Step 2: rubbing agent, foaming agent, adhesive, wetting agent and other auxiliary materials are added sequentially in deionized water,
Stirred with 1000r/min revolving speed to mixing well, grinding, degassing be made lotion to get.
The ulcer healing of 1 root bark of tree peony polysaccharide of effect example is tested
Healthy guinea pig 30, half male and half female, 1.5~1.7kg of weight, all animals give full price by Experimental Animal Center
Pellet is unified to raise.One cotton pellet is placed in and directly passes through glass tube one end (being allowed to concordant with nozzle) for 5mm, then by glass
Pipe is placed in 90% carbolic acid solution, and medical fluid is made to be impregnated with cotton balls, and the cotton balls end of glass tube is then placed in cavy side cheek mucous membrane
On burn 60s, observed after 24~48h, occur the ulcer directly through about 5mm on cavy mucous membrane of mouth.By ulcerated 30 globefish
Mouse is randomly divided into 3 groups, and every group 10, blank control group: without any drug therapy；Test group: the external application of root bark of tree peony polysaccharide is used
Treatment, drug control group: Bingpeng San external curing.3d starts medication and records the variation of ulcer area, observes skin surface
Redness degree around infection conditions and ulcer, and ulcer diameter average value is calculated, it the results are shown in Table 1.
Table 1
From the data in the table, root bark of tree peony polysaccharide has the effect of promoting ulcer healing.
Effect example 2
This tests 400 people of screening, and patient age 15-70 years old, canker sore of the seizure frequency less than 30 days was frequently sent out
Canker sore stage of attack is in when making patient, and participating in test, it is desirable that it can understand the effect of expression test front and back, and not have
Other similar experimental study is participated in simultaneously., must not be within the gestational period and nursing period if it is women, 400 people are divided into 4 groups, often
100 people of group；Effect before and after record detection use；It heals in 5 days, and without recurrence in 90 days, for effectively control；Symptom in 5 days
Mitigate, and heal in 15 days, and recurrent number is less than or equal to 1 time in 90 days, is remission；Symptom object variation or 15 in 5 days
In it disunion or in 90 days recurrent number be more than or equal to 2 times, then be it is invalid, the results are shown in Table 2.
It is grouped situation:
Test one group: behind toothpaste 90 days of the continuous use preparation of the embodiment of the present invention 1 (once in the morning and once at night)；
Test two groups: behind toothpaste 90 days of the continuous use preparation of the embodiment of the present invention 4 (once in the morning and once at night)；
Compare one group: behind toothpaste 90 days of the continuous use preparation of comparative example 1 of the present invention (once in the morning and once at night)；
Compare two groups: behind toothpaste 90 days of the continuous use preparation of comparative example 2 of the present invention (once in the morning and once at night)；
Table 2
| Effectively control number | Remission number | Invalid number | |
| Test one group | 63 | 37 | 0 |
| Test two groups | 45 | 52 | 3 |
| Compare one group | 0 | 29 | 71 |
| Compare two groups | 0 | 5 | 95 |
Embodiment described above is merely a preferred embodiment of the present invention, and the simultaneously exhaustion of the feasible implementation of non-present invention.It is right
For persons skilled in the art, any aobvious to made by it under the premise of without departing substantially from the principle of the invention and spirit and
The change being clear to should be all contemplated as falling within claims of the invention.
Claims (9)
1. application of the root bark of tree peony polysaccharide as drug activity ingredient in preparation prevention and treatment stomatocace medicine.
2. root bark of tree peony polysaccharide is preparing the application in anti-treating dental ulcer toothpaste as drug activity ingredient.
3. a kind of toothpaste containing root bark of tree peony polysaccharide, which is characterized in that including root bark of tree peony polysaccharide, by weight percentage, the root bark of tree peony
Polysaccharide accounts for the 0.2~0.5% of toothpaste total weight.
4. a kind of toothpaste containing root bark of tree peony polysaccharide according to claim 3, which is characterized in that by weight percentage, also
Menthol including accounting for toothpaste total weight 0.5~1%.
5. a kind of toothpaste containing root bark of tree peony polysaccharide according to claim 3, which is characterized in that
By weight percentage, further include following raw material: accounting for the rubbing agent of toothpaste total weight 25~60%；Account for toothpaste gross weight
The wetting agent of amount 10~55%；Account for the adhesive of toothpaste total weight 0.3~1.5%；Account for the hair of toothpaste total weight 1.5~2.5%
Infusion；Account for the stabilizer of toothpaste total weight 1.5~3.0%；Deionized water surplus.
6. a kind of toothpaste containing root bark of tree peony polysaccharide according to claim 5, which is characterized in that
The rubbing agent includes one or more of dicalcium phosphate dihydrate, hydrated silica, calcium carbonate, aluminium hydroxide；
The wetting agent includes one or more of glycerol, propylene glycol, sorbierite；
The foaming agent includes one or more of laruyl alcohol sodium sulfovinate, sodium N-lauroyl sarcosinate；
Described adhesive include one of sodium carboxymethylcellulose, carboxyethyl cellulose, xanthan gum, melon Lovell glue, carragheen or
It is several；
The stabilizer uses tetrasodium pyrophosphate.
7. according to a kind of described in any item preparation methods of the toothpaste containing root bark of tree peony polysaccharide of claim 3~6, feature exists
In, specifically includes the following steps:
Step 1: weighing each raw material in proportion, after root bark of tree peony polysaccharide deionized water dissolving, obtains root bark of tree peony polysaccharide solution, for use；
Step 2: by rubbing agent, foaming agent, adhesive, wetting agent and other auxiliary materials, it is added sequentially to the root bark of tree peony made from step 1
Polysaccharide solution selectively adds menthol after stirring 10min, continues stirring to mixing well, lotion is made in grinding, degassing, i.e.,
?.
8. according to a kind of described in any item the answering in reparation canker sore of the toothpaste containing root bark of tree peony polysaccharide of claim 3~6
With.
9. a kind of toothpaste containing root bark of tree peony polysaccharide according to claim 4 it is anti-inflammatory it is antibacterial, go halitosis, repair canker sore
In application.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823721A (en) * | 2006-01-09 | 2006-08-30 | 张英强 | Compounding of peony natural organic compound series tooth paste product and its preparation method |
| CN102670442A (en) * | 2012-05-14 | 2012-09-19 | 云南云科药业有限公司 | Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof |
| CN107260578A (en) * | 2017-06-15 | 2017-10-20 | 广州暨南生物医药研究开发基地有限公司 | A kind of children's toothpaste containing argyi leaf polysaccharide and preparation method thereof |
| CN108704006A (en) * | 2018-07-31 | 2018-10-26 | 卫招辉 | A kind of tree peony cell activity liquid and preparation method thereof |
| CN109276475A (en) * | 2018-11-20 | 2019-01-29 | 湖北中医药大学 | One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof |
-
2019
- 2019-01-31 CN CN201910094609.2A patent/CN109549948A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823721A (en) * | 2006-01-09 | 2006-08-30 | 张英强 | Compounding of peony natural organic compound series tooth paste product and its preparation method |
| CN102670442A (en) * | 2012-05-14 | 2012-09-19 | 云南云科药业有限公司 | Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof |
| CN107260578A (en) * | 2017-06-15 | 2017-10-20 | 广州暨南生物医药研究开发基地有限公司 | A kind of children's toothpaste containing argyi leaf polysaccharide and preparation method thereof |
| CN108704006A (en) * | 2018-07-31 | 2018-10-26 | 卫招辉 | A kind of tree peony cell activity liquid and preparation method thereof |
| CN109276475A (en) * | 2018-11-20 | 2019-01-29 | 湖北中医药大学 | One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof |
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Application publication date: 20190402 |