CN111939172A - Disinfectant for women and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of gynecological nursing medicines, and discloses a disinfectant for women and a preparation method thereof, wherein raw materials are prepared according to parts by weight; dissolving polyhexamethylene guanidine hydrochloride, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol into purified deionized water, and stirring to obtain a homogeneous solution; adding purified deionized water to full volume, and performing constant volume and aging; inspecting the obtained intermediate product; if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product; and (5) inspecting the finished product, and storing the qualified product in a finished product warehouse. The invention has the characteristics of sterilization effect on staphylococcus aureus, pseudomonas aeruginosa and candida albicans, good stability, broad-spectrum and high-efficiency sterilization effect, mild and non-irritant effect, skin care, water retention, damp and heat removal, special use for women and good disinfection and sterilization effect.

Description

Disinfectant for women and preparation method thereof

Technical Field

The invention belongs to the technical field of gynecological nursing medicines, and particularly relates to a disinfectant for women and a preparation method thereof.

Background

The disinfectant is one of necessities for life, can ensure environmental sanitation, personal sanitation and object surface cleanness and sanitation, and has wide application range and large use amount. Especially, if the perineum of women and gynecology is not nursed properly, inflammation is easy to cause, which not only affects the health of the perineum, but also can cause embarrassment in public places. Vaginitis, pruritus vulvae and the like are common gynecological diseases, and the number of commonly used treatment medicines is not dozens. Accordingly, there is an increasing demand for feminine care products, not only for daily hygiene care, but also for self-healing after symptoms have developed.

The skin of the private part of the female is relatively fragile and easy to be damaged, so that the required disinfectant has the characteristics of mild effect, small irritation and low toxicity. In the current commercially available special disinfectant for women, a plurality of brands are favored by consumers, such as Fuyanjie, Jieeryin, gynecologic Qianjin and the like, wherein the Jieeryin disinfectant has broad-spectrum sterilization, but has strong irritation when being used in an internal infusion, and the gynecologic Qianjin disinfectant can not eliminate vaginal inflammation and has no effect on abnormal pudendum pruritus caused by damp heat. The Fuyanjie has the highest market share in the market at present, is used as a Chinese and western compound disinfectant, has the main component of chlorhexidine acetate for disinfection and sterilization, has the mechanism of destroying cell wall plasma membranes of pathogenic microorganisms and quickly killing gram-positive bacteria, gram-negative bacteria, bacterial spores, fungi, viruses and the like, and has the advantages of low toxicity, small toxic and side effects, no local stimulation, extremely rare allergic reaction and the like. Fuyanjie mainly has the bacteriostatic action on staphylococcus aureus, candida albicans, escherichia coli and the like, has relatively mild effect, is suitable for internal flushing, but has the defects of narrow antibacterial surface, incapability of treating inflammation and no curative effect on gynecological inflammation.

Therefore, the current commercially available special disinfectant for women has the technical defects of not ideal disinfection effect, narrow antibacterial surface, incapability of treating inflammation, no effect on symptoms caused by damp heat and strong irritation.

Disclosure of Invention

Aiming at the problems in the prior art, the invention provides a disinfectant for women and a preparation method thereof.

The disinfectant for women is prepared from, by weight, 0.2% -0.22% of polyhexamethylene guanidine hydrochloride, 0.2% of fatty alcohol-polyoxyethylene ether, 0.03% of hydroxypropyl methyl cellulose, 0.05% of peppermint oil, 2% of glycerol and the balance of purified deionized water.

Furthermore, the purity of the polyhexamethylene guanidine hydrochloride is 95%, the purity of the fatty alcohol-polyoxyethylene ether is 99%, the purity of the hydroxypropyl methyl cellulose is 99%, the purity of the peppermint oil is 50%, and the purity of the glycerol is 99%.

Furthermore, every 1000kg of the disinfectant for women consists of 2kg of polyhexamethylene guanidine hydrochloride with the purity of 95%, 2kg of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.3kg of hydroxypropyl methyl cellulose with the purity of 99%, 0.5kg of peppermint oil with the purity of 50%, 20kg of glycerin with the purity of 99%, and the balance of purified deionized water.

The invention also aims to provide a preparation method of the disinfectant for women, which comprises the following steps:

preparing raw materials in parts by weight: 0.2-0.22% of polyhexamethylene guanidine hydrochloride with the purity of 95%, 0.2% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.03% of hydroxypropyl methyl cellulose with the purity of 99%, 0.05% of peppermint oil with the purity of 50%, 2% of glycerin with the purity of 99% and the balance of purified deionized water;

dissolving polyhexamethylene guanidine hydrochloride, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol, and stirring to obtain a homogeneous solution;

adding purified deionized water to full volume, and performing constant volume and aging;

step four, inspecting the obtained intermediate product;

step five, if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;

and step six, inspecting the finished products, and storing the qualified products in a finished product warehouse.

The invention aims to overcome the defects that the existing commercially available disinfectant has narrow antibacterial surface, no effect on symptoms caused by damp heat and strong irritation, and an ideal disinfection product which has broad and efficient sterilization spectrum and mild effect and can remove damp heat is obtained by adding other components, so that the defects of the prior art are overcome.

The invention is realized by the following main components, including polyhexamethylene guanidine hydrochloride, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose and peppermint oil, and is characterized by containing the polyhexamethylene guanidine hydrochloride, and the mechanism is as follows: (1) guanidine compounds have higher activity, polymers are electropositive, and various bacteria and viruses are easy to adsorb because of electronegativity, so that the bacteria and the viruses cannot divide and reproduce and lose activity; (2) the structure of the cell membrane is collapsed to form a transmembrane pore, the cell membrane is broken to destroy the energy metabolism of the microorganism, and the activity of the bacterial virus is lost; (3) the polymer can form a layer of film to seal the breathing channel of the microorganism, so that the microorganism is suffocated; the sterilization mechanism is independent of the form and the species of the microorganism, the effect of the microorganism cannot be influenced even if the microorganism is variant or variant, and the microorganism does not generate drug resistance to the polyhexamethylene guanidine salt; the fatty alcohol-polyoxyethylene ether has the main functions of improving the affinity of oil stain and water and providing detergency, has the characteristics of good detergency, insensitivity to hard water, small foam and the like as a nonionic surfactant, and is more convenient for clean cleaning of private parts of women; the hydroxypropyl methyl cellulose has the main functions of an emulsifier, a thickener and a dispersant, so that the disinfectant is more viscous as a whole, and the components are well and uniformly dispersed; the main function of the peppermint oil is to make the smell fresh and comfortable and to have the efficacy of dispelling damp and heat; the glycerin has the main functions of retaining water and moistening the skin and has the function of nursing the skin mucosa; water is the solvent.

The raw materials of the invention are polyhexamethylene guanidine hydrochloride, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol respectively, and purified deionized water is used as a solvent. Considering that the components need to be prepared into homogeneous solution, so that the components need good water solubility and cannot generate adverse reaction or adverse effect mutually, and the components respectively play due roles, such as good water solubility of the polyhexamethylene guanidine hydrochloride and obvious sterilization effect, the recommended dosage of different purposes of various manufacturers is considered, generally, the recommended dosage of personal care products such as antibacterial fabrics is 0.3-0.6%, the recommended dosage of wet tissue products such as non-woven fabrics or wet towels is 0.2-0.3%, the recommended dosage of the mixed aqueous solution is 0.05-0.5%, the recommended dosage and the application object of the invention are female sensitive areas, and the moderate and low dosages are suitable, so the dosage range of the polyhexamethylene guanidine hydrochloride used in the invention is 0.2-0.22%; the fatty alcohol-polyoxyethylene ether is a good nonionic surfactant, has the characteristics of degreasing, safety, no toxicity, no irritation to skin, small foam generation amount, insensitivity to hard water and the like, is good in water solubility, easy to rinse and easy to mix with other substances, and usually the surfactant plays roles of sterilization, synergism, emulsification, foaming and the like in a disinfectant, the dosage is usually not more than 1%, and the dosage is preferably 0.2% in consideration of the action object of the invention and no foaming or emulsifying effect; hydroxypropyl methylcellulose is a good dispersing agent and thickening agent, although the water solubility is slightly poor, the hydroxypropyl methylcellulose can be completely dissolved in water by a proper dissolving method, so that the system viscosity is increased while the uniform dispersion of the system is assisted, and the thickening effect is extremely obvious, and the sanitation standard is not described, so that the dispersing and thickening purposes can be realized by using extremely small amount of hydroxypropyl methylcellulose, and 0.03 percent of hydroxypropyl methylcellulose is selected as the using amount; the peppermint oil is colorless or light yellow clear liquid, has good water solubility and special cool fragrance, can kill insects and mites, has the effect of refreshing and restoring consciousness, is usually used as an additive, does not specifically describe the peppermint oil according to various technical requirements, is usually used as the additive by referring to patents or description conditions of other disinfection products, has the addition amount of 0.02-2 percent, and is suitable for using a lower addition amount in consideration of the action object of the peppermint oil, so 0.05 percent is selected as the addition amount; the glycerin is chemically named as glycerol, is miscible with water in any proportion, has the effects of water retention and skin moistening, is commonly used in detergents, cosmetics and medicines, refers to patents or descriptions of other disinfection products, and is usually used as an additive, the addition amount is usually 1-5%, the use object of the invention does not need to be frequently used, and the requirements on skin moistening and water retention are not high, so that the addition amount of 2% is more suitable. By combining the characteristics of the components, the water solubility can meet the requirements, no incompatibility occurs between the components, no adverse reaction or adverse effect occurs, the components can respectively play the roles of respective fields, and a homogeneous solution with the expected effect can be obtained.

The disinfectant disclosed by the invention belongs to an environment-friendly high-molecular polymer sterilization disinfectant, has broad-spectrum and high-efficiency sterilization effect, is mild and non-irritant in effect, is convenient to clean and remove dirt, nurses the skin, preserves water and moistens the skin, has fresh smell and dispels damp-heat, and is an ideal special female disinfection product with three effects of sterilization, cleaning and nursing and dispelling damp-heat.

Drawings

FIG. 1 is a flow chart of the method for preparing the disinfectant for women according to the embodiment of the present invention.

FIG. 2 is a flow chart of the production process of the disinfectant for women according to the embodiment of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The technical solution of the present invention is described in detail below with reference to the accompanying drawings.

The disinfectant for women provided by the embodiment of the invention comprises, by weight, 0.2% -0.22% of polyhexamethylene guanidine hydrochloride with the purity of 95%, 0.2% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.03% of hydroxypropyl methyl cellulose with the purity of 99%, 0.05% of peppermint oil with the purity of 50%, 2% of glycerol with the purity of 99%, and the balance of purified deionized water.

The disinfectant for women provided by the embodiment of the invention is prepared from the following components in every 1000 kg: 2kg of polyhexamethylene guanidine hydrochloride with the purity of 95 percent, 2kg of fatty alcohol-polyoxyethylene ether with the purity of 99 percent, 0.3kg of hydroxypropyl methyl cellulose with the purity of 99 percent, 0.05kg of peppermint oil with the purity of 50 percent, 20kg of glycerin with the purity of 99 percent and the balance of purified deionized water.

In a preferred embodiment of the invention, polyhexamethyleneguanidine hydrochloride, fatty alcohol-polyoxyethylene ether, hydroxypropylmethylcellulose, peppermint oil, glycerin are technical grade.

As shown in fig. 1, the method for preparing a disinfectant solution for women according to an embodiment of the present invention includes the following steps:

s101: preparing raw materials in parts by weight: 0.2-0.22% of polyhexamethylene guanidine hydrochloride with the purity of 95%, 0.2% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.03% of hydroxypropyl methyl cellulose with the purity of 99%, 0.05% of peppermint oil with the purity of 50%, 2% of glycerin with the purity of 99% and the balance of purified deionized water;

s102: dissolving polyhexamethylene guanidine hydrochloride, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol in purified deionized water, and stirring to obtain a homogeneous solution;

s103: adding purified deionized water to full volume, and performing constant volume and aging;

s104: inspecting the obtained intermediate product;

s105: if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;

s106: and (5) inspecting the finished product, and storing the qualified product in a finished product warehouse.

The technical solution of the invention is further described below with reference to specific embodiments.

Example (b):

the prescription of 1000kg of the product comprises:

the product mainly has the bactericidal effect, and the component of the product is polyhexamethylene guanidine hydrochloride, so that the killing rate of staphylococcus aureus, escherichia coli, candida albicans and gonococcus reaches 100%. The product has the following experimental and performance test results:

list of polyhexamethylene guanidine toxicities

In situ sterilization test

Test site	Basis of judgment	EXAMPLES results	Result judgment
				Surface of an object	The national regulation is more than 90 percent	99.83％	Meet the requirements
Surface of palm	The national regulation is more than 90 percent	97.65％	Meet the requirements

Polyhexamethylene guanidine stability

Comparison of various disinfectant products

By combining the data, the disinfectant disclosed by the invention belongs to an environment-friendly high-molecular polymer sterilization disinfectant, has a sterilization effect on staphylococcus aureus, pseudomonas aeruginosa and candida albicans, is good in stability, has a broad-spectrum and high-efficiency sterilization effect, is mild and non-irritant in effect, is convenient to clean and remove dirt, nurses the skin, preserves water and moistens the skin, has fresh smell, removes damp heat, and is an ideal female disinfection product with three effects of sterilization, cleaning and nursing and removing damp heat.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (5)

1. The disinfectant for women is characterized by comprising, by weight, 0.2% -0.22% of polyhexamethylene guanidine hydrochloride, 0.2% of fatty alcohol-polyoxyethylene ether, 0.03% of hydroxypropyl methyl cellulose, 0.05% of peppermint oil, 2% of glycerol and the balance of purified deionized water, wherein the balance is made up by supplementing to 100%.

2. The disinfectant for women according to claim 1, wherein the purity of the salt of polyhexamethylene guanidine is 95%, the purity of fatty alcohol-polyoxyethylene ether is 99%, the purity of hydroxypropyl methyl cellulose is 99%, the purity of peppermint oil is 50%, and the purity of glycerin is 99%.

3. The disinfectant solution for women according to claim 1, wherein each 1000kg of the disinfectant solution for women comprises 2kg of 95% pure polyhexamethylene guanidine hydrochloride, 2kg of 99% pure fatty alcohol-polyoxyethylene ether, 0.3kg of 99% pure hydroxypropyl methylcellulose, 0.5kg of 50% pure peppermint oil, 20kg of 99% pure glycerin, and the balance of purified deionized water.

4. The method for preparing the disinfectant solution for women according to claim 1, wherein the method for preparing the disinfectant solution for women comprises the following steps:

preparing raw materials in parts by weight: 0.2-0.22% of polyhexamethylene guanidine hydrochloride with the purity of 95%, 0.2% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.03% of hydroxypropyl methyl cellulose with the purity of 99%, 0.05% of peppermint oil with the purity of 50%, 2% of glycerin with the purity of 99% and the balance of purified deionized water;

dissolving polyhexamethylene guanidine hydrochloride, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol in purified deionized water, and stirring to obtain a homogeneous solution;

adding purified deionized water to full volume, and performing constant volume and aging;

step four, inspecting the obtained intermediate product;

step five, if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;

and step six, inspecting the finished products, and storing the qualified products in a finished product warehouse.

5. A nursing medicine prepared from the disinfectant liquid for women according to any one of claims 1 to 3.

Images