CN113491709B - Multifunctional high-efficiency compound disinfectant and preparation method thereof - Google Patents
Multifunctional high-efficiency compound disinfectant and preparation method thereof Download PDFInfo
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- CN113491709B CN113491709B CN202010256495.XA CN202010256495A CN113491709B CN 113491709 B CN113491709 B CN 113491709B CN 202010256495 A CN202010256495 A CN 202010256495A CN 113491709 B CN113491709 B CN 113491709B
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 63
- 150000001875 compounds Chemical class 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 14
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- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 7
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- 241000220317 Rosa Species 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims 3
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims 3
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- 238000012360 testing method Methods 0.000 description 19
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 14
- 230000000844 anti-bacterial effect Effects 0.000 description 14
- 230000002147 killing effect Effects 0.000 description 10
- 239000003899 bactericide agent Substances 0.000 description 8
- 238000001514 detection method Methods 0.000 description 8
- -1 polyhexamethylene monoguanidine Chemical class 0.000 description 8
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 7
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 7
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- 238000013095 identification testing Methods 0.000 description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
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- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 3
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
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- 239000000047 product Substances 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Chemical class CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- FNXLCIKXHOPCKH-UHFFFAOYSA-N bromamine Chemical compound BrN FNXLCIKXHOPCKH-UHFFFAOYSA-N 0.000 description 1
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- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical compound C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a multifunctional high-efficiency compound disinfectant and a preparation method thereof, wherein the disinfectant comprises the following main components: 0.01 to 2.0 percent of polyhexamethylene biguanide hydrochloride (PHMB), 0.05 to 0.2 percent of water-soluble quaternary ammonium salt, 0.1 to 2.0 percent of surfactant, 0.05 to 1.5 percent of thickener, 0.05 to 2.0 percent of humectant, 0.001 to 0.1 percent of essence, 0 to 40.0 percent of medical ethanol and the balance of pure water. The high-efficiency multifunctional compound disinfectant has the characteristics of wide sterilization spectrum (obvious sterilization effect on staphylococcus aureus, escherichia coli, candida albicans, influenza virus and other pathogens), wide application range, wide use method (sterilization during wiping, soaking and flushing), no toxicity, environmental protection, long acting and the like; the compound component has the advantages of low dosage and high activity, and the preparation cost is relatively low; the polyhexamethylene biguanide hydrochloride is used as a main active ingredient, is not absorbed by skin, does not remain, does not generate drug resistance to various microorganisms, has no toxic or side effect, and can meet the requirements of people on safety disinfectants.
Description
Technical Field
The invention relates to the technical field of disinfectant, in particular to a multifunctional high-efficiency compound disinfectant and a preparation method thereof.
Background
The existence of microorganisms such as viruses, bacteria, fungi and the like directly threatens the health of human beings and the development of society, so that the development of a disinfectant with broad spectrum, high efficiency, rapidness, low toxicity, convenient carrying, convenient use and wide application range becomes a current research hotspot. Currently, there are two problems with the study of disinfectants: firstly, the safe, efficient, environment-friendly and broad-spectrum ideal disinfectant has high research and development cost and great difficulty; second, the single chemical synthesis disinfectant is easy to generate drug resistance for microorganisms after long-term use.
Along with the continuous progress of society, the living standard of people is continuously improved, and the sanitary civilization consciousness is also continuously enhanced. Thus, people are more concerned about sanitation and safety in various public places. The sterilization composition and the sterilization dose affect the sterilization effect of the sterilization agent in various types. Resistance to bacteria, fungi, viruses, etc. also affects the bactericidal effect. Green chemistry has received attention from a vast number of scholars in the new century and has become one of the leading edges of international scientific research. Therefore, researchers of bactericides at home and abroad are focusing on research and development of ideal bactericides with safety, high efficiency, environmental protection and broad spectrum. Because of the high cost and great difficulty in developing the ideal bactericide, researchers mainly research the bactericide compounding, synergistic effect, action mechanism and the like.
Guanidine and quaternary ammonium salt disinfectants are novel environment-friendly disinfectants, have extremely strong sterilization and bacteriostasis properties, are broad-spectrum and efficient, have long effective period, have no toxic or side effect, have no corrosiveness and irritation, are safe to use, are degradable in natural environment, are environment-friendly and have no pollution, and are main components for developing novel disinfectants in recent years.
The quaternary ammonium salt bactericide comprises a single-chain (such as benzalkonium chloride and benzalkonium bromide) and a double-chain quaternary ammonium salt (such as bisdecanyl dimethyl ammonium chloride and DDAC), one end of the quaternary ammonium salt bactericide is positively charged, the other end of the quaternary ammonium salt bactericide is long-chain fatty alkane/aromatic hydrocarbon, and belongs to a cationic surface active disinfectant.
The guanidine bactericide comprises chlorhexidine acetate, glucose chlorhexidine, polyhexamethylene monoguanidine, polyhexamethylene biguanide salt derivatives and the like, and for example, chlorhexidine sold in the market comprises chlorhexidine acetate and glucose chlorhexidine compound preparations as main components. Guanidine sterilization mechanism is similar to quaternary ammonium salt, guanidine with a large amount of positive charges can be adsorbed on the surface of bacteria rapidly, and replace Mg2+ and Ca2+ which exist on the surface stably, and mainly interact with lipopolysaccharide, peptidoglycan components and cytoplasmic membranes on cell walls to change phospholipid environment of cell membranes, so that biological dysfunction of the cell membranes is caused, and the structure of the cytoplasmic membranes is destroyed, so that the microorganisms are killed. In addition, as a polymer, polyhexamethylene mono/biguanide (PHMG/PHMB) can form a membrane on the surface of the microorganism to close the respiratory passages, and thus the bacteria can die by choking. It is known that the single-component bactericidal spectrum is narrow, such as 100% of the doses of polyhexamethylene guanidine hydrochloride for E.coli, staphylococcus aureus and Candida albicans are only 200ppm, but not suitable for killing cell spores. For example, the quaternary ammonium salt has a certain bactericidal capacity to pseudomonas aeruginosa which is common in a hospital surgery room besides the bactericidal capacity which is the same as that of polyhexamethylene guanidine hydrochloride, wherein the dosage of 99.999 percent of the bactericidal capacity is only 39ppm, but the bactericidal effect to virus is weak. Researches show that when the active components are compounded in a certain proportion, the compounded disinfectant has a synergistic effect, the compounded disinfectant can broaden the sterilization group spectrum and enhance the sterilization capacity, for example, the literature reports that the disinfectant compounded by guanidine with ethanol, bisdodecyl dimethyl ammonium chloride, benzalkonium bromide and chlorhexidine acetate respectively has better effect, wherein the compounded disinfectant compounded by guanidine with bisdodecyl dimethyl ammonium chloride has the best sterilization effect. In addition: the compounded disinfectant can effectively reduce the dosage of the disinfectant under the condition of guaranteeing the sterilization standard, and achieves the purposes of high efficiency, low toxicity, economy and practicality.
Disclosure of Invention
Aiming at some problems existing in the current disinfectant, the invention purposefully develops a high-efficiency compound disinfectant, and aims to provide a multifunctional high-efficiency compound disinfectant which has good disinfection effect, is nontoxic, green and environment-friendly and has low cost.
The technical scheme for realizing the invention is as follows: the multifunctional high-efficiency compound disinfectant is characterized by being prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 0.01～2.0％ |
| Water-soluble quaternary ammonium salt | 0.05～0.2％ |
| Surface active agent | 0.1～2.0％ |
| Thickening agent | 0～1.5％ |
| Humectant type | 0～2.0％ |
| Essence | 0.001～0.1％ |
| Medical ethanol | 0～40.0％ |
| Pure water | Allowance of |
The multifunctional high-efficiency compound disinfectant is characterized in that: the dosage of the polyhexamethylene biguanide hydrochloride (PHMB) is 0.01-2.0%; the water-soluble quaternary ammonium salt is one of benzalkonium chloride/bromoamine, bisdodecyl dimethyl ammonium chloride (DDAC) and benzethonium bromide, and the dosage of the water-soluble quaternary ammonium salt is 0.05-0.2%.
The multifunctional high-efficiency compound disinfectant is characterized in that: the surfactant is one or more of polyoxyethylene ether (AEO/JFC/NP/OP/TX), glyceryl Monostearate (GM), cocamidopropyl betaine 8 (CAB) and Alkyl Polyglycoside (APG), and the dosage is 0.1-2.0%.
The hand-washing-free high-efficiency compound disinfectant is characterized in that: the thickening agent is one or more of polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyvinylpyrrolidone or carbomer, and the dosage of the thickening agent is 0.05-1.5%.
The multifunctional high-efficiency compound disinfectant is characterized in that: the humectant is one or more of glycerol, propylene glycol, aloe gel, sodium hyaluronate, carbamide, mel, sodium lactate, sorbitol, pyrrolidone carboxylic acid, and gelatin, and the dosage is 0.05-2.0%.
The multifunctional high-efficiency compound disinfectant is characterized in that: the essence is one of rose, jasmine, lavender, sandalwood, peppermint, strawberry and the like in the plant essence, and the dosage of the essence is 0.001-0.1%.
The multifunctional high-efficiency compound disinfectant is characterized in that: the preparation method comprises the following steps:
(1) Dissolving solid medicines in the component table in water in advance to prepare water solution with corresponding concentration for later use;
(2) Respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, surfactant, thickener, humectant, essence and medical ethanol into a reaction kettle with mechanical stirring, and then adding pure water to supplement to a certain volume;
(3) Mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) Filtering and sub-packaging the uniformly stirred solution to obtain the high-efficiency compound multifunctional disinfectant.
The invention has the following advantages:
1. the main effective sterilization components of the multifunctional high-efficiency compound disinfectant provided by the invention are the non-toxic and environment-friendly polymer guanidine and double-chain quaternary ammonium salt, so that an effective protective film can be formed on the surface of skin, and the multifunctional high-efficiency compound disinfectant has the effects of high-efficiency sterilization and long-acting bacteriostasis.
2. The multifunctional high-efficiency compound disinfectant provided by the invention adopts a compound formula, fully utilizes the synergistic effect of all the components, and has the advantages of small dosage, good sterilization effect, wide sterilization spectrum and the like.
3. The multifunctional high-efficiency compound disinfectant provided by the invention contains the surfactant, can effectively enhance the sterilization effect of the main component, reduces the irritation, and has the advantages of no skin chapping and no peeling after use.
4. The multifunctional high-efficiency compound disinfectant provided by the invention contains components for moisturizing skin, and has the characteristics of good moisturizing effect, non-stickiness and high comfort level after use.
5. The multifunctional high-efficiency compound disinfectant provided by the invention has the advantages of simple preparation process, low equipment requirement and relatively low cost.
6. The multifunctional high-efficiency compound disinfectant provided by the invention is green, environment-friendly, free of toxic and side effects, and suitable for a wide range of people.
7. The multifunctional high-efficiency compound disinfectant provided by the invention is convenient and quick to use, is free of washing and can be carried about.
8. The multifunctional disinfectant provided by the invention can kill escherichia coli, staphylococcus aureus and candida albicans within 1min, and the killing rate of influenza virus pathogenic bacteria is up to more than 99.999%.
9. The multifunctional disinfectant provided by the invention can be prepared into the disinfectant suitable for surgical hands, sanitary hands, hard object surfaces, fabrics and other porous object surfaces according to the formula adjustment proportion, and has wide application range and strong adaptability.
Detailed Description
The following provides a further detailed description of the embodiments of the present invention.
Example 1
The multifunctional high-efficiency compound disinfectant of the embodiment is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) Dissolving solid medicines in the component table in water in advance to prepare water solution with corresponding concentration for later use;
(2) Respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and then adding pure water to supplement to a certain volume;
(3) Mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) Filtering and sub-packaging the uniformly stirred solution to obtain the high-efficiency compound multifunctional disinfectant.
Example 2
The multifunctional high-efficiency compound disinfectant of the embodiment is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) Dissolving solid medicines in the component table in water in advance to prepare water solution with corresponding concentration for later use;
(2) Respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and then adding pure water to supplement to a certain volume;
(3) Mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) Filtering and sub-packaging the uniformly stirred solution to obtain the high-efficiency compound hand-free disinfectant.
Example 3
The multifunctional high-efficiency compound disinfectant of the embodiment is prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 0.5％ |
| Didecaalkyl Dimethyl Ammonium Chloride (DDAC) | 0.15％ |
| Polyvinylpyrrolidone (PVP) | 1.5％ |
| Propylene glycol | 2.0％ |
| Alkyl Polyglucoside (APG) | 0.5％ |
| Rose essence | 0.01％ |
| Medical ethanol | 10.0％ |
| Deionized water | Allowance of |
The preparation method comprises the following steps:
(1) Dissolving solid medicines in the component table in water in advance to prepare water solution with corresponding concentration for later use;
(2) Respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and then adding pure water to supplement to a certain volume;
(3) Mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) Filtering and sub-packaging the uniformly stirred solution to obtain the high-efficiency compound hand-free disinfectant.
Example 4
The multifunctional high-efficiency compound disinfectant of the embodiment is prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 1％ |
| Didecaalkyl Dimethyl Ammonium Chloride (DDAC) | 0.2％ |
| Carbomer 934 | 1.5％ |
| Propylene glycol | 2.0％ |
| Cocamidopropyl betaine (CAB) | 0.5％ |
| Lemon essence | 0.01％ |
| Medical ethanol | 30.0％ |
| Deionized water | Allowance of |
The preparation method comprises the following steps:
(1) Dissolving solid medicines in the component table in water in advance to prepare water solution with corresponding concentration for later use;
(2) Respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and then adding pure water to supplement to a certain volume;
(3) Mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) Filtering and sub-packaging the uniformly stirred solution to obtain the high-efficiency compound hand-free disinfectant.
Example 5
The multifunctional high-efficiency compound disinfectant of the embodiment is prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 2.0％ |
| Didecaalkyl Dimethyl Ammonium Chloride (DDAC) | 0.2％ |
| Polyvinylpyrrolidone (PVP) | 1.5％ |
| Glycerol | 0 |
| Cocamidopropyl betaine (CAB) | 0.5％ |
| Rose essence | 0.01％ |
| Medical ethanol | 0 |
| Deionized water | Allowance of |
The preparation method comprises the following steps:
(1) Dissolving solid medicines in the component table in water in advance to prepare water solution with corresponding concentration for later use;
(2) Respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and then adding pure water to supplement to a certain volume;
(3) Mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) Filtering and sub-packaging the uniformly stirred solution to obtain the high-efficiency compound hand-free disinfectant.
Example 6
The following is an analysis and detection report by a third party detection agency (Engelt detection technology service (Shanghai) Inc.), the test item is a complete skin irritation experiment of the disinfection product, and the sample is the multifunctional high-efficiency compound disinfectant of example 3.
Sample state: has normal appearance and no obvious defect.
The following is an analysis and detection report by a third party detection agency (Engell detection technology service (Shanghai) Inc.), the test items are a neutralizer identification test (Candida albicans) and a fungus quantitative killing test (Candida albicans), and the sample is the multifunctional high-efficiency compound disinfectant of example 3.
1. Equipment and method for manufacturing the same
1. Test strain: candida albicans was supplied by engel detection technology service (Shanghai) limited, generation 5-6 fresh slant cultures.
2. Test sample: the multifunctional high-efficiency compound disinfectant of example 3.
3. Neutralizing agent: D/E broth.
4. Other: organic interferents at a concentration of 3%, standard hard water, etc.
2. Method of
1. The detection basis is as follows: the neutralizer identification test and the quantitative fungus killing test were carried out in accordance with the ministry of health, disinfection technical Specification (2002 edition) 2.1.1.5.5 and 2.1.1.9.
2. Neutralization agent identification test: the test samples were reacted with standard hard water 1:4 dilutions and candida albicans for 0.5min. The test temperature was 19-21℃and the test was repeated 3 times.
3. Quantitative fungus killing test: the test sample stock solution is used, and the action time is respectively 1.25min, 2.5min and 3.75min. The test temperature was 19-21℃and the test was repeated 3 times.
3. Results
1. Neutralization agent identification test
In 3 repeated experiments, the error rates of the recovered colonies of the three groups of 3, 4 and 5 are 9.87%, 5.62% and 9.46% respectively. The results are shown in Table 2.
Table 2 neutralization agent identification test results
Note that: the negative control group was grown aseptically.
2. Killing effect on test bacteria
The results of 3 repeated tests show that the multifunctional compound disinfectant has the effect on candida albicans for 1.25min, 2.5min and 3.75min, the killing logarithmic value is more than 4.00, and the results are shown in table 3.
TABLE 3 quantitative test results of fungi killing
4. Conclusion(s)
1. The result of 3 repeated tests shows that the D/E broth neutralizer can neutralize the sterilizing component in the compound disinfectant, and the neutralizer and the neutralization product have no obvious influence on the growth of test bacteria and the culture medium. The neutralizer is suitable for quantitative killing test of candida albicans by the test sample.
2. 3 repeated experiments show that the hand-free disinfectant has the effect on candida albicans in suspension for 1.25min, 2.5min and 3.75min, and the killing logarithmic values are all more than 4.00.
The above specific examples are only some of the embodiments of the present invention, and improvements and modifications can be made to the formulation and preparation method of the present invention without departing from the scope of the present invention, and such improvements and modifications are also considered to be within the scope of the present invention.
Claims (2)
1. The multifunctional high-efficiency compound disinfectant is characterized by comprising the following main components: polyhexamethylene biguanide hydrochloride (PHMB) 0.5%, didecyl Dimethyl Ammonium Chloride (DDAC) 0.15%, alkyl Polyglycoside (APG) 0.5%, polyvinylpyrrolidone 1.5%, propylene glycol 2.0%, rose essence 0.01%, medical ethanol 10%, and deionized water in balance.
2. The multifunctional high-efficiency compound disinfectant as set forth in claim 1, wherein the preparation method comprises the following steps:
(1) Dissolving solid medicines in the component table in water in advance, and preparing an aqueous solution with corresponding concentration for later use;
(2) Respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), bisdecanyl dimethyl ammonium chloride (DDAC), alkyl Polyglycoside (APG), polyvinylpyrrolidone, propylene glycol, rose essence and medical ethanol into a reaction kettle with mechanical stirring, and adding deionized water to supplement to a certain volume;
(3) Mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) Filtering and sub-packaging the uniformly stirred solution to obtain the multifunctional high-efficiency compound disinfectant.
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| CN114631538A (en) * | 2022-04-22 | 2022-06-17 | 中国大熊猫保护研究中心 | Disinfectant for panda colony house, preparation method and disinfection method |
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