CN101548683B - Liquid disinfectant and method of producing the same - Google Patents
Liquid disinfectant and method of producing the same Download PDFInfo
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- CN101548683B CN101548683B CN 200910114009 CN200910114009A CN101548683B CN 101548683 B CN101548683 B CN 101548683B CN 200910114009 CN200910114009 CN 200910114009 CN 200910114009 A CN200910114009 A CN 200910114009A CN 101548683 B CN101548683 B CN 101548683B
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Abstract
The invention discloses a liquid disinfectant suitable for hospital and other places, and method of producing the same. The method adopts polyamine propyl biguanide with strong sterilizing force, goodstability and no skin hypersusceptibility phenomena as the main ingredient; selects nonylphenol polyethenoxy ether as surfactant, which can not only enhances the bactericidal effect, but also increas es the product stability; adds fragrance to make the disinfectant have the fragrance smell, the simple proportioning reaches the same disinfecting effect. The invention has advantage of low fabricating cost and simple preparation technique, and is simultaneously non-toxic non-corrosive, thereby minimizing the impact on the surrounding environment.
Description
Technical field
The present invention relates to the disinfectant field, especially be applicable to the liquid disinfectant in the places such as hospital.
Background technology
Natural world exists various microorganisms, comprise various bacterial propagules, fungi, gemma, virus etc., the pathogenic microorganism that wherein human body is worked the mischief must be killed removing, therefore, outside 20th-century disease pathogenic microorganism is carried out timely and effective sterilization, prevent disease is propagated, and control inside-hospital infection and guarantee health of people are of great significance.
Can select the number of chemical disinfectant to environment disinfected at present, commonly used have chloride class disinfectant, aldehyde disinfectant, peroxide disinfectant, iodine class disinfectant, alcohol disinfectant, a quaternary ammonium disinfectant etc., they have respectively pluses and minuses separately, remarkable such as chloride class disinfectant, aldehyde disinfectant, peroxide sanitizer disinfecting effect, belong to high effect disinfectants, but the corrosivity to article is higher, especially not only corrosivity is strong for chloride class disinfectant, aldehyde disinfectant, and tanginess, larger to skin and mucous membrane irritation, stability is also relatively poor; In recent years, biguanides disinfectant more and more is taken seriously, the scope of application is also more and more extensive, it not only has stronger killing action to bacterium and germ, and have colourless, tasteless, nontoxic, non-corrosive good characteristic, can be widely used in the disinfection of body surface, air, skin and mucous membrane.
Have much about biguanides disinfectant at present, prescription is complicated mostly, and composition is on the high side.(application number: 03139646.1), composition comprised 9 kinds of quaternary ammonium salt, biguanides, aldehydes, surfactant, urea, EDETATE SODIUM salt etc. such as disclosed Chinese patent application on February 25 " liquid disinfectant " in 2004; November in 2006 Granted publication on the 8th United States Patent (USP) " fast acting disinfectant and cleaner " (application number: 00802830.3) composition comprises the Multiple components such as poly double-guanidine, quaternary ammonium salt, multivalent intercalating agent and surfactant, not only cause preparation technology numerous and diverse, and increased production cost.
Summary of the invention
The invention provides a kind of liquid disinfectant, under the prerequisite that does not reduce sterilization effect, solved that sanitizer formulations complicated component in the past, preparation are numerous and diverse, the problem of high expensive.
Another object of the present invention provides the preparation method of aforesaid liquid disinfectant.
Liquid disinfectant of the present invention, said composition is composed of the following components by weight percentage:
Biguanides in the above-mentioned component is PHMB.
Surfactant in the above-mentioned component is polyoxyethylene nonylphenol ether.
Prepare the method for disinfectant of the present invention, mainly may further comprise the steps:
(1) surfactant is mixed with biguanides, stirred 15 minutes;
(2) essence is joined in the mixed liquor, stirred 5 minutes;
(3) ionized water is joined in the mentioned solution, stirred 10 minutes;
Above steps is all carried out at normal temperatures and pressures.
The present invention is by selecting sterilizing power strong, good stability and be main component without the PHMB of allergic phenomena to skin, select polyoxyethylene nonylphenol ether as surfactant, thereby disinfectant is adsorbed on prolongs its time of contact on the carrier, not only strengthened bactericidal effect, and increased the stability of product, add essence so that disinfectant possesses faint scent, simple proportioning reaches same Disinfection Effect, therefore to have a production cost low in the present invention, the simple advantage of preparation technology, simultaneously because nontoxic non-corrosiveness has reduced the impact on surrounding enviroment to greatest extent.
Embodiment
Liquid disinfectant of the present invention is take biguanides as main component, ratio in prescription joins PHMB to polyoxyethylene nonylphenol ether, stirred 15 minutes at reactor under the normal temperature and pressure, make it to form compound chemical thimerosal 1, then add essence, continue to stir 5 minutes at reactor, form thimerosal 2, then add ionized water, stir and to obtain disinfectant of the present invention in 10 minutes.
Get disinfectant of the present invention and carry out sterilization, sterilization, metal erosion, the test such as allergic, embodiment is as follows:
Embodiment 1: for the Escherichia coli killing effect
Under 19 ℃ of-20 ℃ of conditions of temperature, with containing PHMB 0.8%, 0.85%, 1.0% thimerosal of the present invention to enterobacteria effect 15min, 30min, 45min, test repeats 3 times respectively, on average kills logarithm value all＞5.00, be judged to be sterilization qualified, the results are shown in Table 1:
Table 1 thimerosal is to colibacillary killing effect
Embodiment 2: to the Candida albicans killing effect
Under 19 ℃ of-20 ℃ of conditions of temperature, respectively with containing PHMB 0.8%, 0.85%, 1.0% thimerosal of the present invention to Candida albicans effect 15min, 30min, 45min, test repeats 3 times, on average kill logarithm value to be respectively＞3.51,＞4.00,＞4.00, the results are shown in Table 2:
Annotate: the negative control asepsis growth
Table 2 thimerosal is to the killing effect of Candida albicans
Embodiment 3: to the surface disinfection field trial
Under 22 ℃ of conditions of temperature, respectively with containing PHMB 0.8%, 0.85%, 1.0% thimerosal of the present invention to the effects such as desktop, table top, go-cart surface, refrigerator be surperficial 30 minutes, test repeats 3 times, and the logarithm value of on average killing of natural bacteria is 1.27, the results are shown in Table 3:
Table 3 thimerosal is to the surface disinfection site test results
Embodiment 4: to the ground sterilization field trial
Under 22 ℃ of conditions of temperature, respectively with containing PHMB 0.8%, 0.85%, 1.0% thimerosal effect of the present invention 30 minutes, be 1.03 to the logarithm value of on average killing of cement flooring, smooth earth natural bacteria, the results are shown in Table 4:
Table 4 thimerosal is to the ground sterilization site test results
Embodiment 5: to metal corrosion test
Under 22 ℃ of conditions of temperature, respectively with contain PHMB 0.8%, 0.85%, 1.0% thimerosal is tested, stainless corrosion rate is 0.0041mm/a, the corrosion rate of carbon steel is 0.1339mm/a, copper corrosion speed is 0.0806mm/a, is 0.0705mm/a to Corrosion of Al speed, and the control group corrosion rate is 0.016mm/a.The results are shown in following table 5:
| Metal species | Average weight (g/ sheet) before the test | Average weight (g/ sheet) after the test | Corrosion rate (mm/a) |
| Stainless steel | 3.4620 | 3.4618 | 0.0041 |
| Carbon steel | 3.4110 | 3.4026 | 0.1339 |
| Copper | 3.6367 | 3.6312 | 0.0806 |
| Aluminium | 1.1389 | 1.1374 | 0.0705 |
| Contrast | 3.43329 | 3.4328 | 0.0016 |
Table 5 thimerosal is to the corrosion of metal degree
Embodiment 6: the test of rat acute toxicity on inhalation
1. tested material: contain PHMB 0.8%, 0.85%, 1.0% thimerosal of the present invention;
2. animal and feed: animal is 20 of Adult SD kind big white mouse, and body weight is 180-220g, animal housing's temperature: 22-25 ℃, and relative moisture: 55-70%.
3. test method: issue " disinfection technology standard " (version in 2002) 2.3.2 acute inhalation toxicity experimental technique according to the Ministry of Public Health.Adopt nearly formula contamination method, operation instruction is per sample established 10000mg/m
3A concentration.Test is put into 0.81*0.81*0.91m with 10 rats (female male half and half) at every turn at twice
3(volume 0.6m
3) airtight lucite cabinet in, spray into the 6g sample solution with sprayer, start simultaneously the small fan in the cabinet, contaminated 2 hours, the poisoning manifestations of observed and recorded animal is weighed weekly once, observes 14 day time, off-test is dissected animal and is carried out gross examination of skeletal muscle, and the acute toxicity of pressing toxicity grading standard evaluation tested material is strong and weak.
4. experimental result: after contamination process and contamination finish, have no animal and poisoning symptom occurs, without animal dead, the gross examination of skeletal muscle no abnormality seen is dissected in off-test.
Embodiment 7: the skin irritatin test
1. tested material: contain PHMB 0.8%, 0.85%, 1.0% thimerosal of the present invention;
2. animal and feed: provide by Guangxi Medical University experimental animal center.Animal is 4 of healthy adult white rabbit, body weight 2.0-2.4kg, female, male dual-purpose, animal housing's temperature: 22-25 ℃, relative moisture: 55-75%.
3. test method: issue " disinfection technology standard " (version in 2002) 2.3.3 skin irritatin test method according to the Ministry of Public Health, adopt a time skin irritatin test method.24h cuts twice mao on family's rabbit back backbone before the experiment, left and right each the about 9cm of unhairing scope
2Get the 0.5mL sample solution and be applied on the one side skin of unhairing of rabbit back, then scope 2.5cm*2.5cm covers with two layers of gauze of the same area and one deck glassine paper, fixes with medical proof fabric again, and opposite side skin compares.Applied ointment or plaster 4 hours, and then removed tested material, clean skin, observation skin reaction in 1,24 and 48 hour after removing tested material.
4. experimental result: after removing tested material, each is observed the tested skin of time point rabbit and is showed no unusually, and contrast skin no abnormality seen press disinfectant the skin irritatin intensity evaluation is stipulated, this sample is to rabbit skin nonirritant.Result of the test sees the following form 6:
Stimulus intensity classification: nonirritant
Table 6 tested material is to irritant reaction grade form of rabbit skin
Claims (2)
1. liquid disinfectant, said composition is composed of the following components by weight percentage:
PHMB 0.8%
Polyoxyethylene nonylphenol ether 0.2%
Essence 0.06%
Ionized water 98.94%.
2. the method for preparing the described disinfectant of claim 1 is characterized in that the method may further comprise the steps composition:
(a) PHMB is mixed with polyoxyethylene nonylphenol ether, stirred 15 minutes, form mixed liquor 1;
(b) essence is joined in the mixed liquor 1, stirred 5 minutes, obtain mixed liquor 2;
(c) ionized water is joined in the mixed liquor 2, stir and to obtain described thimerosal in 10 minutes;
Above steps is all carried out at normal temperatures and pressures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910114009 CN101548683B (en) | 2009-04-25 | 2009-04-25 | Liquid disinfectant and method of producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910114009 CN101548683B (en) | 2009-04-25 | 2009-04-25 | Liquid disinfectant and method of producing the same |
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| Publication Number | Publication Date |
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| CN101548683A CN101548683A (en) | 2009-10-07 |
| CN101548683B true CN101548683B (en) | 2013-02-13 |
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| CN 200910114009 Expired - Fee Related CN101548683B (en) | 2009-04-25 | 2009-04-25 | Liquid disinfectant and method of producing the same |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104170879A (en) * | 2014-08-01 | 2014-12-03 | 青岛蓬勃石油技术服务有限公司 | Anticorrosive bactericide for oilfield reinjection water and preparation method of anticorrosive bactericide |
| CN111374142A (en) * | 2020-03-12 | 2020-07-07 | 天天向上(宁波)医疗科技有限公司 | Disinfecting emulsion, preparation method thereof and disinfecting wet tissue prepared from disinfecting emulsion |
| CN112741116A (en) * | 2021-01-15 | 2021-05-04 | 四川恒博生物科技有限公司 | Silver ion composite disinfection and sterilization sporicide based on hydrogen peroxide |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1391809A (en) * | 2002-08-12 | 2003-01-22 | 杨生 | Skin sterilizing agent before operation |
| CN1476761A (en) * | 2003-07-02 | 2004-02-25 | 刘瑞源 | Liquid disinfectant |
| CN101176700A (en) * | 2007-10-29 | 2008-05-14 | 广东庆发药业有限公司 | Antimicrobial disinfection hand cleanser and preparation method thereof |
-
2009
- 2009-04-25 CN CN 200910114009 patent/CN101548683B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1391809A (en) * | 2002-08-12 | 2003-01-22 | 杨生 | Skin sterilizing agent before operation |
| CN1476761A (en) * | 2003-07-02 | 2004-02-25 | 刘瑞源 | Liquid disinfectant |
| CN101176700A (en) * | 2007-10-29 | 2008-05-14 | 广东庆发药业有限公司 | Antimicrobial disinfection hand cleanser and preparation method thereof |
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| CN101548683A (en) | 2009-10-07 |
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