CN112675119A - Antibacterial infant wash-free bubble hand sanitizer and preparation method thereof - Google Patents
Antibacterial infant wash-free bubble hand sanitizer and preparation method thereof Download PDFInfo
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- CN112675119A CN112675119A CN202110026655.6A CN202110026655A CN112675119A CN 112675119 A CN112675119 A CN 112675119A CN 202110026655 A CN202110026655 A CN 202110026655A CN 112675119 A CN112675119 A CN 112675119A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 27
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 23
- 239000003906 humectant Substances 0.000 claims abstract description 22
- 239000004094 surface-active agent Substances 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000003755 preservative agent Substances 0.000 claims abstract description 15
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- 239000008213 purified water Substances 0.000 claims abstract description 11
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- 230000002421 anti-septic effect Effects 0.000 claims abstract description 8
- -1 antiseptic Substances 0.000 claims abstract description 8
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 6
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- 238000000034 method Methods 0.000 claims description 6
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- 206010040880 Skin irritation Diseases 0.000 abstract description 13
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- 238000001354 calcination Methods 0.000 description 8
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- 239000003795 chemical substances by application Substances 0.000 description 7
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- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 5
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 238000013095 identification testing Methods 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
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- 241001103617 Pseudomonas aeruginosa ATCC 15442 Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
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- 239000002390 adhesive tape Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000011173 biocomposite Substances 0.000 description 1
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- 235000019864 coconut oil Nutrition 0.000 description 1
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- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
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- 239000002994 raw material Substances 0.000 description 1
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- 229910052709 silver Inorganic materials 0.000 description 1
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- 230000008591 skin barrier function Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229940095696 soap product Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical group [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
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Abstract
The application relates to an antibacterial infant washing-free bubble hand sanitizer and a preparation method thereof, wherein the antibacterial infant washing-free bubble hand sanitizer comprises the following components: antibacterial agent, surfactant, antiseptic, humectant and pH regulator; according to the total mass of the antibacterial infant wash-free bubble hand sanitizer, the antibacterial agent comprises 0.10-0.50% of HyCal powder and 0.10-0.20% of benzalkonium chloride; the surfactant comprises 1.00-5.00% coco glucoside, 1.00-10.00% cocamidopropyl betaine; the preservative comprises 0.05-0.25% of ethylparaben; the humectant comprises 1.00-5.00% of butanediol; the pH regulator comprises 0.01-0.02% of citric acid; the balance being purified water. The application has the effect of improving the skin irritation of the hand sanitizer without washing to infants.
Description
Technical Field
The application relates to the field of hand sanitizer, in particular to an antibacterial infant wash-free bubble hand sanitizer and a preparation method thereof.
Background
The no-clean hand sanitizer is a cleaning product which can clean hands without using towels, water and soap. The existing hand-washing-free disinfection gel contains a large amount of alcohol, and after the hand skin is used for multiple times, the skin barrier is damaged, so that the skin is dry, chapped, red and swollen, itchy and stabbing pain. The epidermis of the skin of infants is a single-pass cell, and the thickness of the epidermis is one tenth of that of the skin of adults, so that the infants are more sensitive to skin irritation. The disposable liquid soap product for infants has the defects at present.
In the prior art, another patent of the present inventor, publication No. CN105854823B, discloses a method for preparing a biocomposite antibacterial adsorbent material, which is characterized in that the preparation method comprises: 1) pretreating, namely soaking the shell in a sodium hydroxide solution, cleaning, drying and coarsely crushing to obtain coarse shell powder; 2) performing first calcination, namely calcining the shell coarse powder in the pretreatment step under a vacuum condition, wherein the calcination temperature is 300-800 ℃, and the calcination time is 1-5 h, so as to obtain first shell coarse powder; 3) second calcining, calcining the shell coarse powder in the pretreatment step in an oxidizing atmosphere, wherein the oxidizing atmosphere is a mixed gas of air and carbon dioxide, the volume ratio of the carbon dioxide to the air is 0.03-0.1%, the calcining temperature is 1000-1400 ℃, and the calcining time is 1-3 hours, so as to obtain second shell coarse powder; 4) crushing, namely cooling the first shell coarse powder and the second shell coarse powder, mixing the first shell coarse powder and the second shell coarse powder in proportion, and crushing to obtain shell micro powder with the particle size of 10-100 nm; 5) embedding, namely embedding the antibacterial polypeptide in the shell micro powder by using an embedding agent, wherein the embedding agent is a sodium polyacrylate solution with the mass concentration of 0.1-0.5% or a polylysine solution with the mass concentration of 0.01-0.1%, the shell micro powder and the antibacterial polypeptideThe mass ratio of the polypeptide is 108:1～106:1. The biological composite antibacterial adsorption material prepared by the preparation method is called HyCal powder. HyCal powder has good bactericidal effect, but is not yet incorporated into infant leave-on hand sanitizer products.
In view of the above-mentioned related arts, the inventors consider that the current leave-on hand sanitizer is still insufficient in terms of skin irritation for infants.
Disclosure of Invention
In order to improve the skin irritation of the no-wash hand sanitizer to infants, the application provides an antibacterial no-wash bubble hand sanitizer for infants and a preparation method thereof.
The application provides an antibacterial infant wash-free bubble hand sanitizer and a preparation method thereof, and the following technical scheme is adopted:
an antibacterial infant wash-free bubble hand sanitizer comprises the following components: antibacterial agent, surfactant, antiseptic, humectant and pH regulator; according to the total mass of the antibacterial infant wash-free bubble hand sanitizer, the antibacterial agent comprises 0.10-0.50% of HyCal powder and 0.10-0.20% of benzalkonium chloride; the surfactant comprises 1.00-5.00% coco glucoside, 1.00-10.00% cocamidopropyl betaine; the preservative comprises 0.05-0.25% of ethylparaben; the humectant comprises 1.00-5.00% of butanediol; the pH regulator comprises 0.01-0.02% of citric acid; the balance being purified water.
By adopting the technical scheme, the HyCal powder contains shell micro powder and antibacterial polypeptide, the antibacterial polypeptide has a good sterilization effect, and is embedded in the shell micro powder, so that the prepared HyCal powder has strong antibacterial property, adsorbability and pesticide degradation performance; the antibacterial agent is prepared by HyCal powder and benzalkonium chloride according to a corresponding proportion, the benzalkonium chloride has broad-spectrum and efficient sterilization and algae killing capability, can effectively control the propagation of bacteria algae and the growth of slime in water, has good slime stripping effect and certain dispersion and permeation effects, has certain deoiling and deodorizing capability and corrosion inhibition effect, and further improves the antibacterial effect of the antibacterial agent; the surfactant comprises coco glucoside and cocoamidopropyl betaine, the coco glucoside has excellent decontamination, foaming, foam stabilizing, emulsifying, dispersing, solubilizing, wetting and penetrating abilities, the cocoamidopropyl betaine has excellent foamability and obvious thickening ability, and the cocoamidopropyl betaine is prepared by taking coconut oil as a raw material, has small irritation, so that the surfactant has good foaming performance, conforms to the mild performance of a human body, and has small irritation to the skin of the human body, particularly to infants; the preservative is ethylparaben, so that the bactericidal effect on fungi is strong; in conclusion, the antibacterial infant wash-free bubble hand sanitizer has a good sterilization effect, is a composition of a neutral and weakly acidic system, conforms to the acid-base property of the skin surface of a human body, is harmless to the health of the human body, has small irritation, is beneficial to improving the skin irritation of the infant, is in a bubble extrusion state, increases the interest of washing hands, can enable the infant to love the hand washing, and is suitable for the infant.
A preparation method of an antibacterial infant wash-free bubble hand sanitizer comprises the following steps:
1) adding purified water into a clean container, adding a surfactant under stirring, stirring and heating to 83 +/-2 ℃, and preserving heat for 10-20 minutes.
2) And (3) cooling the container, mixing and dissolving the humectant and the preservative in advance, adding the solution prepared by mixing and dissolving the humectant and the preservative into the container under the stirring condition when the temperature in the container is reduced to 55 +/-5 ℃, and then uniformly stirring.
3) The temperature in the container is reduced to 42 plus or minus 2 ℃, and the antibacterial agent and the pH regulator are added into the solution under the condition of stirring.
By adopting the technical scheme, the preparation method well combines all components in the antibacterial infant wash-free bubble hand sanitizer to prepare the hand sanitizer, protects the structures of all components, particularly antibacterial polypeptide in an antibacterial agent, and ensures the sterilization performance and safety of the antibacterial infant wash-free bubble hand sanitizer.
Preferably, the stirring speed is 30-50 r/min.
By adopting the technical scheme, the stirring speed is 30-50r/min, which is beneficial to ensuring the diffusion rate of the components.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the antibacterial infant wash-free bubble hand sanitizer has a good sterilization effect, is a composition of a neutral and weakly acidic system, conforms to the acid-base property of the skin surface of a human body, is harmless to the health of the human body, has small irritation, and is beneficial to improving the skin irritation of the infant;
2. the preparation method well combines all components in the antibacterial infant no-clean bubble hand sanitizer to prepare the hand sanitizer, protects the structures of all components, particularly antibacterial polypeptide in an antibacterial agent, and ensures the sterilization performance and safety of the antibacterial infant no-clean bubble hand sanitizer.
Detailed Description
The present application will be described in further detail with reference to examples 1 to 3 and comparative examples 1 to 2.
The embodiment of the application discloses an antibacterial infant wash-free bubble hand sanitizer and a preparation method thereof.
Example 1
An antibacterial infant wash-free bubble hand sanitizer comprises the following components: antibacterial agent, surfactant, antiseptic, humectant and pH regulator; according to the total mass of the antibacterial infant wash-free bubble hand sanitizer, the antibacterial agent comprises 0.50% of HyCal powder and 0.20% of benzalkonium chloride; the surfactant comprises 5.00% coco glucoside, 10.00% cocoamidopropyl betaine; the preservative comprises 0.25% ethylparaben; the humectant comprises 5.00% butylene glycol; the pH regulator comprises 0.02% of citric acid; the balance being purified water.
A preparation method of an antibacterial infant wash-free bubble hand sanitizer comprises the following steps:
1) adding purified water into a clean container, adding a surfactant under stirring, stirring and heating to 83 +/-2 ℃, and preserving heat for 10-20 minutes.
2) And (3) cooling the container, mixing and dissolving the humectant and the preservative in advance, adding the solution prepared by mixing and dissolving the humectant and the preservative into the container under the stirring condition when the temperature in the container is reduced to 55 +/-5 ℃, and then uniformly stirring.
3) The temperature in the container is reduced to 42 plus or minus 2 ℃, and the antibacterial agent and the pH regulator are added into the solution under the condition of stirring.
Example 2
An antibacterial infant wash-free bubble hand sanitizer comprises the following components: antibacterial agent, surfactant, antiseptic, humectant and pH regulator; according to the total mass of the antibacterial infant wash-free bubble hand sanitizer, the antibacterial agent comprises 0.10% of HyCal powder and 0.10% of benzalkonium chloride; the surfactant comprises 1.00% coco glucoside, 1.00% cocoamidopropyl betaine; the preservative comprises 0.05% of ethylparaben; the humectant comprises 1.00% butylene glycol; the pH regulator comprises 0.01% of citric acid; the balance being purified water.
Wherein, the preparation method of the antibacterial infant wash-free bubble hand sanitizer is the same as the embodiment 1.
Example 3
An antibacterial infant wash-free bubble hand sanitizer comprises the following components: antibacterial agent, surfactant, antiseptic, humectant and pH regulator; according to the total mass of the antibacterial infant wash-free bubble hand sanitizer, the antibacterial agent comprises 0.35% of HyCal powder and 0.17% of benzalkonium chloride; the surfactant comprises 3.57% coco glucoside, 3.57% cocoamidopropyl betaine; the preservative comprises 0.14% ethylparaben; the humectant comprises 3.21% butanediol; the pH regulator comprises 0.015% of citric acid; the balance being purified water.
Wherein, the preparation method of the antibacterial infant wash-free bubble hand sanitizer is the same as the embodiment 1.
Comparative example 1
An antibacterial infant wash-free bubble hand sanitizer comprises the following components: antibacterial agent, surfactant, antiseptic, humectant and pH regulator; according to the total mass of the antibacterial infant wash-free bubble hand sanitizer, the antibacterial agent comprises 0.35% of HyCal powder and 0.33% of benzalkonium chloride; the surfactant comprises 6.7% coco glucoside, 12.57% cocoamidopropyl betaine; the preservative comprises 0.14% ethylparaben; the humectant comprises 3.21% butanediol; the pH regulator comprises 0.015% of citric acid; the balance being purified water.
Comparative example 2
An antibacterial infant wash-free bubble hand sanitizer comprises the following components: antibacterial agent, surfactant, antiseptic, humectant and pH regulator; according to the total mass of the antibacterial infant wash-free bubble hand sanitizer, the antibacterial agent comprises 0.05% of HyCal powder and 0.33% of benzalkonium chloride; the surfactant comprises 6.7% coco glucoside, 12.57% cocoamidopropyl betaine; the preservative comprises 0.14% ethylparaben; the humectant comprises 3.21% butanediol; the pH regulator comprises 0.015% of citric acid; the balance being purified water.
The application aims at the test and detection of the sterilization effectiveness of the antibacterial infant wash-free bubble hand sanitizer prepared in the examples 1-3 and the comparative examples 1-2. The following description will be made only by taking the procedure of the sterilization test of the antibacterial hands-free bubble washing solution for infants in example 3 as an example, and the procedure is as follows:
first, equipment
1. Test strains: coli 8099, pseudomonas aeruginosa ATCC15442, staphylococcus aureus ATCC6538, candida albicans ATCC 10231.
2. Neutralizing agent: D/E neutralizes the broth.
3. And (3) disinfection solution: and (4) stock solution.
Second, method
1. The inspection basis is as follows: the neutralizer identification test and the quantitative sterilization test are respectively carried out according to 2.1.1.5 and 2.1.1.7 and 2.1.1.9 of disinfection technical Specification (2002 edition) of Ministry of health. The standard requirement of killing log value KL is as follows: escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus are more than or equal to 5.00; candida albicans is greater than or equal to 4.00.
2. And (3) identification test of a neutralizer: the neutralizing agent D/E used neutralizes the broth. The action time of the test stock solution is 0.5min, the test is repeated for three times, and the test strain is candida albicans.
Three, result in
1. Neutralizer identification test
Group 1: adding 1.0mL of bacterial suspension to 4.0mL of test sample liquid, acting for a preset time, adding 0.5mL of uniformly mixed liquid into 4.5mL of diluent, sucking 1.0mL, and culturing and counting.
Group 2: adding 1.0mL of bacterial suspension to 4.0mL of test sample liquid, acting for a preset time, adding 4.5mL of neutralizer into 0.5mL of uniformly mixed liquid, uniformly mixing for l0min, sucking 1.0mL, culturing, counting, and diluting by 10 times of diluent.
Group 3: adding 0.4mL of hard water into 0.1mL of bacterial suspension, uniformly mixing, adding 4.5mL of neutralizing agent, uniformly mixing for 10min, absorbing 1.0mL of culture count, and diluting with 10 times of neutralizing agent.
Group 4: 0.1mL of the bacterial suspension was added to 4.9mL of the neutralized product, mixed and incubated for l0min, 1.0mL of the suspension was aspirated and counted, diluted 10-fold with the neutralized product.
Group 5: adding 0.1mL of bacterial suspension into 0.4mL of hard water, mixing, adding 4.5mL of diluent, mixing for 10min, sucking 1.0mL, culturing, counting, and diluting with 10 times of diluent.
Group 6: diluent, neutralizer and hard water were each 1.0mL inoculated into plates.
The results are shown in Table 1.
TABLE 1 neutralizer identification test results
Groups 3, 4, and 5 had similar amounts of test bacteria grown and had a group error rate of 6.7% (< 15%), group 6 was aseptically grown and the neutralizer was rated acceptable.
2. Killing effect on test bacteria
Adding 0.5mL of organic interfering substance into 0.5mL of bacterial suspension, uniformly mixing in a water bath for 5min, adding 4.0mL of disinfectant, acting for a preset time, adding 0.5mL of mixed solution into 4.5mL of neutralizer, uniformly mixing, taking a proper dilution, inoculating 1.0mL of neutralizing agent into a plate, performing viable bacteria culture counting, and simultaneously performing a control sample. The results are detailed in table 2.
TABLE 2 log kill of the samples to the test bacteria KL
Fourth, conclusion
The results of three repeated tests show that the stock solution of the sample acts for 0.5min, 1.0min and 1.5min, the killing log values of escherichia coli, staphylococcus aureus and pseudomonas aeruginosa are all greater than 5.00, and the killing log values of candida albicans are all greater than 4.00, so that the sample has the killing effect on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and candida albicans.
The application also aims at the skin irritation test of the antibacterial infant wash-free bubble hand sanitizer prepared in the examples 1-3 and the comparative examples 1-2. The following description is given by way of example only of the multiple complete skin irritation test for the antibacterial, baby-wash-free bubble hand sanitizer of example 3, and is as follows:
materials and methods
1. Test article
1.1. Subject information:
subject name: the baby wash-free bubble hand sanitizer.
Preparing a test substance: applied as is.
The dosage is as follows: 0.5 mL.
1.2. And (4) comparing no information: none.
2. Laboratory animals and breeding environments
2.1. Laboratory animal information
The species are as follows: new Zealand rabbits. Grade: a normal stage.
Animal number and sex: 3, 1 male and 2 female.
Animal sources: professional cooperative society of silver sea animal husbandry in Tongxiang city.
The supplier produces a license number: SCXK (Zhe) 2018-.
Weight: 2.4 kg-2.5 kg.
2.2. Feeding and environmental information
Animal use license number: SYXK (threo) 2018-0028.
The feed source is as follows: taicanu Anmu fly Biotechnology Ltd.
Feed production license number: threo-feed (2019) 05030.
Room temperature: 23.4-25.4 ℃.
Relative humidity: 45.1 to 64.5 percent.
Drinking water: the water is freely drunk.
Illumination: 12h light/12 h dark.
And (3) ventilation frequency: not less than 8 times/h.
3. The test method comprises the following steps:
the samples submitted by the offeror were subjected to a number of complete skin irritation tests in accordance with the Disinfection protocol (2002 edition). The test animals were shaved on both sides of the spinal column of the back 24h before the test without damaging the skin. The dehairing range was about 3cm by 3cm on each of the left and right.
The following day, the test article was applied directly to the 3cm x 3cm right depilated intact skin, covered with a layer of non-irritating oilpaper, and then secured with a non-irritating adhesive tape. The depilated skin on the other side was coated with 0.5ml of distilled water as a control. The application time was 4 h. Removing residual test substance with warm water or non-irritant solvent. Once daily, apply 14d continuously. The hair should be cut as necessary before each application and the results observed at 24h after each application, the control and test areas were treated the same.
The average score is calculated according to the formula by scoring the irritation response according to Table 2-11 in Disinfection Specification (2002 edition), and the level of the irritation intensity of the test substance to the animal skin is evaluated according to Table 2-12 in the Specification.
TABLE 3 results of multiple skin irritation tests of test substances on rabbits
And (4) checking and concluding: under the test condition, the test result of the test object on home immunity repeated complete skin irritation is nonirritant.
In summary, the results of the sterilization effectiveness and skin irritation tests of the plant extract-containing no-wash hand sanitizer gels of examples 1-3 and comparative examples 1-2 are shown in the following table:
TABLE 4
In conclusion, the antibacterial infant washing-free bubble hand sanitizer disclosed by the embodiments 1 to 3 has a good sterilization effect, and has no irritation to skin and high safety.
The implementation principle of the antibacterial infant wash-free bubble hand sanitizer and the preparation method thereof in the embodiment of the application is as follows: the antibacterial infant wash-free bubble hand sanitizer has a good sterilization effect, is a composition of a neutral and weakly acidic system, accords with the acid-base property of the skin surface of a human body, is harmless to the health of the human body, has small irritation, and is beneficial to improving the skin irritation of the hand sanitizer to infants.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.
Claims (3)
1. An antibacterial infant wash-free bubble hand sanitizer is characterized by comprising the following components: antibacterial agent, surfactant, antiseptic, humectant and pH regulator; according to the total mass of the antibacterial infant wash-free bubble hand sanitizer, the antibacterial agent comprises 0.10-0.50% of HyCal powder and 0.10-0.20% of benzalkonium chloride; the surfactant comprises 1.00-5.00% coco glucoside, 1.00-10.00% cocamidopropyl betaine; the preservative comprises 0.05-0.25% of ethylparaben; the humectant comprises 1.00-5.00% of butanediol; the pH regulator comprises 0.01-0.02% of citric acid; the balance being purified water.
2. The preparation method of the antibacterial infant wash-free bubble hand sanitizer according to claim 1, wherein the preparation method comprises the following steps: the method comprises the following steps:
1) adding purified water into a clean container, adding a surfactant under stirring, stirring and heating to 83 +/-2 ℃, and preserving heat for 10-20 minutes.
2) And (3) cooling the container, mixing and dissolving the humectant and the preservative in advance, adding the solution prepared by mixing and dissolving the humectant and the preservative into the container under the stirring condition when the temperature in the container is reduced to 55 +/-5 ℃, and then uniformly stirring.
3) The temperature in the container is reduced to 42 plus or minus 2 ℃, and the antibacterial agent and the pH regulator are added into the solution under the condition of stirring.
3. The preparation method of the antibacterial infant wash-free bubble hand sanitizer according to claim 2, wherein the preparation method comprises the following steps: the stirring speed is 30-50 r/min.
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Cited By (1)
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| CN114159352A (en) * | 2021-12-16 | 2022-03-11 | 广州温雅日用化妆品有限公司 | Bacteriostatic and itching-relieving foam shampoo |
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Application publication date: 20210420 |