CN101176700A - Antimicrobial disinfection hand cleanser and preparation method thereof - Google Patents
Antimicrobial disinfection hand cleanser and preparation method thereof Download PDFInfo
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- CN101176700A CN101176700A CNA2007100312249A CN200710031224A CN101176700A CN 101176700 A CN101176700 A CN 101176700A CN A2007100312249 A CNA2007100312249 A CN A2007100312249A CN 200710031224 A CN200710031224 A CN 200710031224A CN 101176700 A CN101176700 A CN 101176700A
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Abstract
The invention relates to antibacterial disinfection liquid soap and a preparation method, which is characterized in comprising steps as follows, (1) adding dodecyl sodium sulfate into the purified water, heating up till 70 to 80DEG C, cooling till the ambient temperature after the solution, to get liquid A; (2) dissolving povidone iodine in the liquid A, to get liquid B; (3) mixing and stirring well nonyl phenol polyethenoxy ether and dodecyl benzene sulfonic acid sodium salt, to get liquid C; (4) stirring well the liquid B and the liquid C, adding glycerin and stirring, to get the antibacterial disinfection liquid soap. The invention adopts povidone iodine which can kill the germ, the virus and the epiphyte efficiently, and combines with by the surface-active material which can remove the stains efficiently to make the liquid soap which has the effect of anti-bacterium, disinfection, decontamination, cleanliness, and no pungency. The invention is applicable to the families, the hotels, the workplaces and other places.
Description
Technical field
The present invention relates to a kind of daily detergent, especially a kind of handwashing liquid of antibiotic and sterilizing.
Background technology
People are in life and work, and both hands unavoidably can contact and have microorganism, even the article of pathogenic microorganism, thereby make the both hands microbiological contamination, as handwashing liquid with the decontamination of washing one's hands merely, only can the flush away pollutant, and can not thoroughly carry out disinfection.In addition, also have a kind of handwashing liquid in the decontamination of washing one's hands, to have sterilization, skin care effect concurrently, a kind of sterilization type handwashing liquid and preparation method thereof is disclosed as Chinese patent application number 03116842.6, it is made up of following component: glycerol, surfactant, 2,4,4-three chloro-2-hydroxyl-diphenyl ether, adjuvant, all the other are purified water or distilled water.And surfactant can be two or more the combination in sodium lauryl sulphate, dodecyl polyethenoxy ether sodium sulfate, betanin, the Cortex cocois radicis oil base diglycollic amide.Adjuvant then contains antiseptic, stabilizing agent etc.European Union is with 2,4, and the long-acting deleterious chlorophenols chemical substance of 4-three these classes of chloro-2-hydroxyl-diphenyl ether is classified " harm environment " material as.
Summary of the invention
Purpose of the present invention just provides a kind of handwashing liquid with antibiotic, sterilization, decontamination and preparation method thereof.
The present invention can realize in the following manner: antimicrobial disinfection hand cleanser is that the feedstock production by following weight parts forms: 1～5 part of povidone iodine, 12～20 parts of NPEs, 5～10 parts of dodecylbenzene sodium sulfonate, 5～10 parts of sodium lauryl sulphates, 1～5 part of glycerol, purified water 50-76 part.Its preparation method may further comprise the steps: (1) is got sodium lauryl sulphate and is added in the purified water, is heated to 70-80 ℃, and the dissolving postcooling gets A liquid to room temperature; (2) povidone iodine is dissolved in the A liquid, gets B liquid; (3) get NPE and mix with dodecylbenzene sodium sulfonate and mix thoroughly, (liquid; (4) with behind B liquid and the C liquid mixing, add the glycerol stirring and evenly mixing, promptly get antimicrobial disinfection hand cleanser.
Povidone iodine is red free flowable powder to brown, dissolving fully in cold water and ethanol, antibacterial, virus, fungus, mycete and spore all there is stronger killing action, stable performance, non-stimulated, be all kinds of first-selections that contain in the iodine microbicide, povidone iodine be developed country's first-selection contain iodine medical bactericide and health and epidemic prevention disinfectant; The aqueous solvent of non-ionic surface active agent NPE, dodecylbenzene sodium sulfonate and anionic can produce abundant foam when washing one's hands, decontamination is arranged; Glycerol is wetting agent.
The present invention's employing has the povidone iodine of efficient kill bacteria, virus, fungus effect, the surfactant that cooperates the high-effective cleansing effect, make have antibiotic, sterilization, decontamination, cleaning, non-irritating handwashing liquid, be applicable to uses such as family, hotel, office space.
The handwashing liquid of the present invention's preparation is a brownish red, and the thick liquid of slight iodine fishy smell is arranged.
One, the antimicrobial disinfection hand cleanser available iodine content is measured, and sees Table 1.
Table 1 antimicrobial disinfection hand cleanser available iodine content determination test
| The sample sequence number | The amount of sample (g) | Sample quota of expenditure solution usage (ml) | Available iodine content (g/L) |
| 1-1 1-2 2-1 2-2 3-1 3-2 | 19.6236 20.1164 20.0270 20.1580 19.9985 20.0903 | 3.87 3.95 3.93 3.95 3.95 3.98 | 2.85 2.84 2.83 2.83 2.85 2.86 |
| Meansigma methods | 2.84 |
Two, stability test:
(1) test that is valid for one year:
1, detects foundation: 2.2.1.2.2 in the Ministry of Public Health " disinfection technology standard " (version in 2002) (defending the method prison sends out [2002] No. 282).Taking by weighing sample 20.0g (being accurate to 0.0001g) tests.
2, detected temperatures: 26 ℃; Humidity: 65%.
3, after 54 ℃ of calorstat seasonings are put 14 days, the test that is valid for one year, its available iodine content rate of descent is 4.03%, sees Table 2.
Table 2 antimicrobial disinfection hand cleanser stability experiment result
| The sample sequence number | Available iodine content (g/L) before preserving | Preserve back available iodine content (mg/L) | Rate of descent (%) |
| 1-1 1-2 2-1 2-2 3-1 3-2 | 2.85 2.84 2.83 2.83 2.85 2.86 | 2.73 2.74 2.73 2.73 2.73 2.71 | |
| Meansigma methods | 2.84 | 2.73 | 4.03 |
(2) 2 years effect duration test:
1, detects foundation: 2.2.1.2.2 in the Ministry of Public Health " disinfection technology standard " (version in 2002) (defending the method prison sends out [2002] No. 282).Taking by weighing sample 20.0g (being accurate to 0.0001g) tests.
2, detected temperatures: 26 ℃; Humidity: 65%.
3,37 ℃ of calorstats were placed after 3 months, the test of 2 years effect duration, and its available iodine content rate of descent is 6.13%, sees Table 3.
Table 3 antimicrobial disinfection hand cleanser stability test result
| The sample sequence number | Available iodine content (g/L) before preserving | Preserve back available iodine content (mg/L) | Rate of descent (%) |
| 1-1 1-2 2-1 2-2 3-1 3-2 | 2.85 2.84 2.83 2.83 2.85 2.86 | 2.67 2.67 2.68 2.66 2.67 2.67 | |
| Meansigma methods | 2.84 | 2.67 | 6.13 |
Three, bactericidal assay:
(1) equipment
1, test specimen: antimicrobial disinfection hand cleanser of the present invention.
2, test strain: staphylococcus glucose coccus ATCC6538 (being called for short staphylococcus aureus down), escherichia coli 8099 are provided by Military Medical Science Institute.Above strain algebraically is 9-12 generation, and prepares bacteria suspension with PBS solution.
3, neutralization reagent: the 0.03mol/L PBS solution that contains 0.5% sodium thiosulfate+0.3% lecithin+2.0% tween 80.
4, measuring pipette (0.1ml, 1.0ml, 5.0ml, 10.0ml), middle test tube, plate, biochemical incubator (LRH-250A) etc.
(2) method
1, detects foundation: GB15979-2002 " disposable use hygienic article sanitary standard " appendix C product bactericidal property, bacteriostasis property and stability test method.Detect and repeat 3 times.
2, nertralizer qualification test: according to GB15979-2002 " disposable use hygienic article sanitary standard " appendix C 3.1.Test organisms is a staphylococcus aureus.Test is grouped into: (1) disinfectant+bacterium liquid; (2) (disinfectant+bacterium liquid)+nertralizer; (3) nertralizer+bacterium liquid; (4) (disinfectant+nertralizer)+bacterium liquid; (5) PBS+ bacterium liquid; (6) with batch PBS; (7) with batch nertralizer; (8) with batch culture medium.With disinfectant 3.13% diluent, 2min tested and repeated 3 times action time.20～22 ℃ of test temperatures.
3, C3.2 in bactericidal assay: GB15979-2002 " the disposable use hygienic article sanitary standard " appendix C.
(3) result
1, nertralizer qualification test:
The average growth of (1) group bacterium number is 0cfu/ml, and the average growth of (2) group bacterium number is 1.60 * 10
2Cfu/ml, (3), the average growth of (4), (5) group bacterium number is close, error rate is 3.73% between three groups.(6), (7), (8) group asepsis growth see Table 4.
Table 4 nertralizer qualification result
| Group | Each test growth bacterium is counted cfu/ml | Average growth bacterium number (cfu/ml) | ||
| 1 | 2 | 3 | ||
| 1 2 3 4 5 6 7 8 | 0 1.60×10 2 1.82×10 4 1.62×10 4 1.74×10 4 0 0 0 | 0 1.40×10 2 1.44×10 4 1.30×10 4 1.36×10 4 0 0 0 | 0 1.80×10 2 1.28×10 4 1.12×10 4 1.20×10 4 0 0 0 | 0 1.60×10 2 1.51×10 4 1.35×10 4 1.43×10 4 0 0 0 |
2, bactericidal assay:
Handwashing liquid 3.13% diluent of the present invention, effect 1min is respectively 95.29% and 98.32% to staphylococcus aureus and colibacillary killing rate, sees Table 5.
Table 5 anti-bacterial hand lotion is to Portugal coccus and colibacillary killing effect
| Strain | Decontaminant concentration (%) | The average bactericidal rate and the scope of effect different time (min) | Average control bacterium number (cfu/ml) | |||
| 1 | 2 | 3 | 4 | |||
| To Portugal coccus escherichia coli | 3.13 3.13 | 95.29 (93.49～ 96.3) 98.32 (97.53～ 99.04) | 99.08 (98.57～ 99.39) 100 (100) | 100 (100) 100 (100) | 100 (100) 100 (100) | 1.46×10 4 1.59×10 4 |
Negative control: diluent, the equal asepsis growth of culture medium.
Four, skin irritation test
(1) material and animal:
1, tried thing: antimicrobial disinfection hand cleanser of the present invention, liquid, stock solution is for examination.
2, animal: 3 in New Zealand man (regular grade) about body weight 2.5kg, provides (quality certification 2002A025 of Guangdong Province number) by Guangdong Medical Lab Animal Center.
3, test condition: regular grade zoopery environmental facility (Guangdong Province Science and Technology Commission: Guangdong probatio inspectionem pecuoarem book 2003C007 number).
(2) method:
1, test basis: " disinfection technology standard " (the 2002nd edition) (defending the method prison sends out [2002] No. 282).
2, method: 24h will respectively cut off about 3 * 3cm earlier before the experiment about the rabbit back wool
2Next day,, will be tried thing 0.5ml and evenly be spread upon a side 2.5 * 2.5cm determining medication under the no skin injury situation
2Unhairing district skin, opposite side is made blank.Use warm water flush away residue behind the drug of topical application 4h.Smear once continuous 14 days every day.Smearing back 24h observed result at every turn, calculating every animal average integral every day (stimulation index) and judge skin irritation intensity.
(3) experimental result:
In observation period, tried new zealand rabbit skin and erythema occurs, other symptom is not found in abnormal responses such as edema, and stimulation index=1.97 see Table 6.
Table 6 rabbit is skin irritation reaction scoring repeatedly
| Smear natural law | Number of animals (only) | The irritant reaction integration | ||||||
| Sample | Contrast | |||||||
| Erythema | Edema | Total points | Erythema | Edema | Total points | |||
| 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 3 | 3 | 3 | 0 | 3 | 0 | 0 | 0 | |
| 4 | 3 | 4 | 0 | 4 | 0 | 0 | 0 | |
| 5 | 3 | 4 | 3 | 7 | 0 | 0 | 0 | |
| 6 | 3 | 6 | 1 | 7 | 0 | 0 | 0 | |
| 7 | 3 | 6 | 4 | 10 | 0 | 0 | 0 | |
| 8 | 3 | 5 | 4 | 9 | 0 | 0 | 0 |
| 9 | 3 | 5 | 3 | 8 | 0 | 0 | 0 |
| 10 | 3 | 5 | 3 | 8 | 0 | 0 | 0 |
| 11 | 3 | 5 | 3 | 8 | 0 | 0 | 0 |
| 12 | 3 | 4 | 3 | 7 | 0 | 0 | 0 |
| 13 | 3 | 4 | 2 | 6 | 0 | 0 | 0 |
| 14 | 3 | 4 | 2 | 6 | 0 | 0 | 0 |
| Every day every integral mean value | 1.98 0 | ||||||
Conclusion: antimicrobial disinfection hand cleanser belongs to subexcite to the repeatedly skin irritation of new zealand rabbit.
Repeatedly the skin irritation test shows: handwashing liquid of the present invention belongs to subexcite to the repeatedly skin irritation of new zealand rabbit.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described, but it is not represented as unique embodiment of the present invention.
Embodiment one
Get 5 gram sodium lauryl sulphates and add 60 gram purified water, be heated to 70 ℃, the dissolving postcooling gets A liquid to room temperature; Get 5 gram povidone iodine and be dissolved in the A solution, get B liquid; Get 20 gram NPEs and mix with 5 gram dodecylbenzene sodium sulfonate, must C liquid; With B liquid and C liquid mixed evenly after, add 5 gram glycerol stirring and evenly mixings, promptly get antimicrobial disinfection hand cleanser.
Embodiment two
Get 10 gram sodium lauryl sulphates and add 66 gram purified water, be heated to 80 ℃, the dissolving postcooling gets A liquid to room temperature; Get 1 gram povidone iodine and be dissolved in the A solution, get B liquid; Get 12 gram NPEs and mix with 10 gram dodecylbenzene sodium sulfonate, must C liquid; With B liquid and C liquid mixed evenly after, add 1 gram glycerol stirring and evenly mixing, promptly get antimicrobial disinfection hand cleanser.
Claims (2)
1. an antimicrobial disinfection hand cleanser is characterized in that being made up of following components by part by weight: 1～5 part of povidone iodine, 12～20 parts of NPEs, 5～10 parts of dodecylbenzene sodium sulfonate, 5～10 parts of sodium lauryl sulphates, 1～5 part of glycerol, purified water 50-76 part.
2. the preparation method of an antimicrobial disinfection hand cleanser is characterized in that may further comprise the steps:
(1) get sodium lauryl sulphate and add in the purified water, be heated to 70-80 ℃, the dissolving postcooling gets A liquid to room temperature;
(2) povidone iodine is dissolved in the A liquid, gets B liquid;
(3) get NPE and mix with dodecylbenzene sodium sulfonate and mix thoroughly, C liquid;
(4) with behind B liquid and the C liquid mixing, add glycerol and mix thoroughly, promptly get antimicrobial disinfection hand cleanser.
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| CNB2007100312249A CN100531706C (en) | 2007-10-29 | 2007-10-29 | Antimicrobial disinfection hand cleanser and preparation method thereof |
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| CNB2007100312249A CN100531706C (en) | 2007-10-29 | 2007-10-29 | Antimicrobial disinfection hand cleanser and preparation method thereof |
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| CN101176700A true CN101176700A (en) | 2008-05-14 |
| CN100531706C CN100531706C (en) | 2009-08-26 |
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| CN101766543A (en) * | 2010-02-10 | 2010-07-07 | 北京欧凯纳斯科技有限公司 | Hand sanitizer containing chlorine dioxide |
| CN101475879B (en) * | 2009-01-19 | 2011-04-06 | 广东拉芳日化有限公司 | Sterilizing skin-protective hand cleanser |
| CN101548983B (en) * | 2009-04-25 | 2011-08-03 | 广西佳华医疗卫生用品有限公司 | Skin disinfectant and method of producing the same |
| CN102475678A (en) * | 2010-11-24 | 2012-05-30 | 江苏省勤奋药业有限公司 | 5% povidone iodine solution |
| CN101548683B (en) * | 2009-04-25 | 2013-02-13 | 广西佳华医疗卫生用品有限公司 | Liquid disinfectant and method of producing the same |
| CN103006464A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing disinfection hand cleaner without water |
| CN103893043A (en) * | 2012-12-28 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | Method for manufacturing disinfectant hand cleaner |
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| CN105154517A (en) * | 2015-07-12 | 2015-12-16 | 上海博优测试技术有限公司 | Method for detecting disinfection effects of liquid soap |
| CN107468706A (en) * | 2017-09-30 | 2017-12-15 | 蚌埠科卫消毒药剂有限公司 | A kind of disinfectant tamed iodine and preparation method thereof |
| CN107496448A (en) * | 2017-09-30 | 2017-12-22 | 蚌埠科卫消毒药剂有限公司 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
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| CN111991317A (en) * | 2020-09-21 | 2020-11-27 | 青岛格林维尔环保技术有限公司 | Hand-washing-free gel containing Chinese herbal medicine components and preparation method thereof |
| CN112450220A (en) * | 2020-12-09 | 2021-03-09 | 北京中科东亚纳米材料科技有限公司 | Low-temperature disinfection material and preparation method thereof |
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| WO2021151403A3 (en) * | 2021-03-24 | 2022-02-17 | 厦门大开生物科技有限公司 | Disinfectant composition containing povidone-iodine and uses thereof |
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Family Cites Families (3)
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| DE19959122A1 (en) * | 1999-12-02 | 2001-06-07 | Spree Chemie Gmbh | Hand cleaner comprises surfactants, solvents, parting compounds, additives, a film-former and/or materials with adhesive properties |
| CN1357613A (en) * | 2001-11-22 | 2002-07-10 | 成都洁利康实业发展有限公司 | Completely fused paper soap and its making process |
| CN1827086A (en) * | 2005-10-18 | 2006-09-06 | 郑起平 | Foaming agent of povidone iodine and method for preparing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101475879B (en) * | 2009-01-19 | 2011-04-06 | 广东拉芳日化有限公司 | Sterilizing skin-protective hand cleanser |
| CN101548983B (en) * | 2009-04-25 | 2011-08-03 | 广西佳华医疗卫生用品有限公司 | Skin disinfectant and method of producing the same |
| CN101548683B (en) * | 2009-04-25 | 2013-02-13 | 广西佳华医疗卫生用品有限公司 | Liquid disinfectant and method of producing the same |
| CN101766543A (en) * | 2010-02-10 | 2010-07-07 | 北京欧凯纳斯科技有限公司 | Hand sanitizer containing chlorine dioxide |
| CN101766543B (en) * | 2010-02-10 | 2012-02-01 | 北京欧凯纳斯科技有限公司 | Hand sanitizer containing chlorine dioxide |
| CN102475678A (en) * | 2010-11-24 | 2012-05-30 | 江苏省勤奋药业有限公司 | 5% povidone iodine solution |
| JP2014518865A (en) * | 2011-05-11 | 2014-08-07 | エイエルシー・セラピューティクス・エルエルシー | Antifungal composition for the treatment of skin and nails |
| CN103006464A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing disinfection hand cleaner without water |
| CN103893043A (en) * | 2012-12-28 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | Method for manufacturing disinfectant hand cleaner |
| CN105154517A (en) * | 2015-07-12 | 2015-12-16 | 上海博优测试技术有限公司 | Method for detecting disinfection effects of liquid soap |
| CN107468706A (en) * | 2017-09-30 | 2017-12-15 | 蚌埠科卫消毒药剂有限公司 | A kind of disinfectant tamed iodine and preparation method thereof |
| CN107496448A (en) * | 2017-09-30 | 2017-12-22 | 蚌埠科卫消毒药剂有限公司 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
| CN110184134A (en) * | 2018-02-22 | 2019-08-30 | 罗曙东 | A kind of formula and preparation method thereof of harmless sterilizable Environmentally-friedisinfection disinfection laundry liquid |
| CN111249220A (en) * | 2020-02-17 | 2020-06-09 | 李立和 | Formula of hand-washing-free efficient disinfection gel |
| CN111991317A (en) * | 2020-09-21 | 2020-11-27 | 青岛格林维尔环保技术有限公司 | Hand-washing-free gel containing Chinese herbal medicine components and preparation method thereof |
| CN112450220A (en) * | 2020-12-09 | 2021-03-09 | 北京中科东亚纳米材料科技有限公司 | Low-temperature disinfection material and preparation method thereof |
| WO2021151403A3 (en) * | 2021-03-24 | 2022-02-17 | 厦门大开生物科技有限公司 | Disinfectant composition containing povidone-iodine and uses thereof |
| CN113491268A (en) * | 2021-05-31 | 2021-10-12 | 山东消博士消毒科技股份有限公司 | Low-temperature hydrogen peroxide disinfectant and preparation method thereof |
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Address after: 514031, on the west side of Ring Road, Meizhou, Guangdong Patentee after: GUANGDONG KELUN PHARMACEUTICAL CO., LTD. Address before: 514031, on the west side of Ring Road, Meizhou, Guangdong Patentee before: Guangdong Qingfa Pharmaceutical Industry Co., Ltd. |