CN107468706A - A kind of disinfectant tamed iodine and preparation method thereof - Google Patents
A kind of disinfectant tamed iodine and preparation method thereof Download PDFInfo
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- CN107468706A CN107468706A CN201710937337.9A CN201710937337A CN107468706A CN 107468706 A CN107468706 A CN 107468706A CN 201710937337 A CN201710937337 A CN 201710937337A CN 107468706 A CN107468706 A CN 107468706A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
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Abstract
The invention discloses a kind of disinfectant tamed iodine, its raw material includes iodine, polyvinylpyrrolidone, NPE, sodium lactate, potassium dihydrogen phosphate, triethanolamine, deionized water；The invention also discloses a kind of preparation method of disinfectant tamed iodine, comprise the following steps：It is standby to prepare polyvinylpyrrolidonesolution solution；Sodium lactate, potassium dihydrogen phosphate are added into stirring and dissolving in deionized water, it is standby that solution A is made；Iodine is added in NPE, stirred 2.5 4 hours, adds solution A, stirs 12 hours, obtains solution B；Solution B is added in polyvinylpyrrolidonesolution solution, stirred 68 hours, adds triethanolamine, is stirred 0.5 1 hours, disinfectant tamed iodine is made.Disinfectant tamed iodine produced by the present invention has the characteristics of Disinfection Effect is good, stability is strong, non-stimulated to skin.
Description
Technical field
The present invention relates to disinfectant preparation field, more particularly to a kind of disinfectant tamed iodine and preparation method thereof.
Background technology
Iodophor is a kind of quick-acting, wide spectrum, disinfectant nontoxic, stimulation is small, can kill bacterial propagule, bacterial spore, disease
The pathogen such as poison, bacteriophage, mycobacteria, protozoon, fungi.Because Iodophor overcomes iodine and the tincture of iodine is insoluble in water, unstable, right
Skin and mucosa irritation is big, coloring the shortcomings of fugitive color does not need ethanol to take off iodine, and make iodine-containing disinfectant application achieve it is prominent
Broken property progress.
However, because the activity of iodine is higher, this also brings influence to the stability of iodine class preparation.Existing PVP-I
Solution typically uses polyvinylpyrrolidone as complexing agent, still, due to the Complexation conditions of polyvinylpyrrolidone and iodine ratio
Harsher, the difficult control of course of reaction, so that part material iodine can not be complexed completely or chelation structure is unstable, from
And the stability of Betagen Solution is influenced whether, and this also brings along detrimental effect for the Disinfection Effect of PVP-I.
The content of the invention
Based on technical problem existing for background technology, the present invention proposes a kind of disinfectant tamed iodine and preparation method thereof, this
Disinfectant tamed iodine made from invention has the characteristics of Disinfection Effect is good, stability is strong, non-stimulated to skin.
The present invention provides a kind of disinfectant tamed iodine, and its raw material includes by weight：Iodine 0.6-1.0 parts, polyvinylpyrrolidine
Ketone 4.5-7.0 parts, NPE 2.0-4.0 parts, sodium lactate 0.3-0.5 parts, potassium dihydrogen phosphate 0.5-1.2 parts, three
Monoethanolamine 0.1-0.4 parts, deionized water 110-150 parts.
Preferably, its raw material includes by weight：Iodine 0.7-0.9 parts, polyvinylpyrrolidone 4.8-6.0 parts, nonyl phenol
APEO 2.6-3.1 parts, sodium lactate 0.35-0.43 parts, potassium dihydrogen phosphate 0.6-1.0 parts, triethanolamine 0.15-0.25
Part, deionized water 120-135 parts.
Preferably, its raw material includes by weight：0.84 part of iodine, 5.53 parts of polyvinylpyrrolidone, NPE
2.81 parts, 0.39 part of sodium lactate, 0.76 part of potassium dihydrogen phosphate, 0.18 part of triethanolamine, 128.49 parts of deionized water.
Preferably, polyvinylpyrrolidone PVP-K30, pharmaceutical grade, purity >=99.5%.
Preferably, NPE TX-10, purity >=99.9%.
Preferably, iodine uses pharmaceutical grade iodine, purity >=99.5.
The present invention also provides a kind of preparation method of disinfectant tamed iodine, comprises the following steps：
S1, polyvinylpyrrolidone is added to stirring and dissolving in deionized water, stirring 6-10 minutes, obtained polyvinylpyrrolidone
Solution for standby；Sodium lactate, potassium dihydrogen phosphate are added into stirring and dissolving in deionized water, 3-5 minutes is stirred, it is standby that solution A is made；
S2, under normal temperature, condition of normal pressure, by iodine add NPE in, stir 2.5-4 hours, add solution
A, 1-2 hours are stirred, obtain solution B；
In S3, the polyvinylpyrrolidonesolution solution that will be obtained in the solution B obtained in S2 addition S1,6-8 hours are stirred, are added
Triethanolamine, 0.5-1 hours are stirred, disinfectant tamed iodine is made.
Preferably, polyvinylpyrrolidonesolution solution is prepared in S1 with preparing the weight ratio of deionized water used in solution A
For 3-4:1.
Preferably, polyvinylpyrrolidonesolution solution is prepared in S1 with preparing the weight ratio of deionized water used in solution A
For 3.3:1.
Preferably, the speed that solution B is added in polyvinylpyrrolidonesolution solution in S3 is 3-4 parts by weight/minute.
The invention provides the disinfectant tamed iodine that a kind of Disinfection Effect is good, stability is strong, iodine and carrier in disinfectant tamed iodine
It is good to be complexed effect, the iodine concentration that dissociates is stable, can kill pathogenic entero becteria, pyococcus and saccharomytes, be applied to
Washed one's hands before sanitary washing sterilization, surgery, the sterilization of skin of infusing, injection site skin, minor cut or wound surface of a wound.System provided by the invention
Preparation Method technique is simple, simple operation, can simply, efficiently prepare the iodophor solution with excellent stability.
Embodiment
Below, technical scheme is described in detail by specific embodiment.
Embodiment 1
A kind of disinfectant tamed iodine provided by the invention, its raw material include by weight：0.84 part of iodine, polyvinylpyrrolidone
（PVP-K30）5.53 parts, NPE（TX-10）2.81 parts, 0.39 part of sodium lactate, 0.76 part of potassium dihydrogen phosphate,
0.18 part of triethanolamine, 128.49 parts of deionized water.
Embodiment 2
A kind of disinfectant tamed iodine provided by the invention, its raw material include by weight：0.72 part of iodine, polyvinylpyrrolidone
（PVP-K30）5.91 parts, NPE（TX-10）2.63 parts, 0.36 part of sodium lactate, 0.94 part of potassium dihydrogen phosphate,
0.16 part of triethanolamine, 133.87 parts of deionized water.
Embodiment 3
A kind of disinfectant tamed iodine provided by the invention, its raw material include by weight：0.87 part of iodine, polyvinylpyrrolidone
（PVP-K30）4.85 parts, NPE（TX-10）3.04 parts, 0.42 part of sodium lactate, 0.63 part of potassium dihydrogen phosphate,
0.24 part of triethanolamine, 122.12 parts of deionized water.
Embodiment 4
A kind of disinfectant tamed iodine provided by the invention, its raw material include by weight：0.79 part of iodine, polyvinylpyrrolidone
（PVP-K30）5.36 parts, NPE（TX-10）2.71 parts, 0.38 part of sodium lactate, 0.82 part of potassium dihydrogen phosphate,
0.21 part of triethanolamine, 131.44 parts of deionized water.
Embodiment 5
A kind of disinfectant tamed iodine provided by the invention, its raw material include by weight：0.96 part of iodine, polyvinylpyrrolidone
（PVP-K30）6.79 parts, NPE（TX-10）2.13 parts, 0.32 part of sodium lactate, 1.16 parts of potassium dihydrogen phosphate,
0.37 part of triethanolamine, 146.54 parts of deionized water.
Embodiment 6
A kind of disinfectant tamed iodine provided by the invention, its raw material include by weight：0.61 part of iodine, polyvinylpyrrolidone
（PVP-K30）4.58 parts, NPE（TX-10）3.85 parts, 0.47 part of sodium lactate, 0.53 part of potassium dihydrogen phosphate,
0.11 part of triethanolamine, 112.04 parts of deionized water.
Embodiment 7
A kind of preparation method of disinfectant tamed iodine provided by the invention, comprises the following steps：
S1,5.12 parts of polyvinylpyrrolidone PVP-K30 are added into stirring and dissolving in 96.38 parts of deionized waters, stirred 8 minutes,
Polyvinylpyrrolidone PVP-K30 solution for standby is made；0.41 part of sodium lactate, 0.70 part of potassium dihydrogen phosphate are added 29.21 parts
Stirring and dissolving in deionized water, stir 4 minutes, it is standby that solution A is made；
S2, under normal temperature, condition of normal pressure, 0.75 part of iodine is added in 2.73 parts of NPE TX-10, stirring 3.3
Hour, solution A is added, stirs 1.2 hours, obtains solution B；
S3, the solution B obtained in S2 added into S1 obtained polyvinylpyrrolidone with the speed of 3.4 parts by weight/minute
In PVP-K30 solution, stir 6.8 hours, add 0.22 part of triethanolamine, stir 0.7 hour, disinfectant tamed iodine is made.
Embodiment 8
A kind of preparation method of disinfectant tamed iodine provided by the invention, comprises the following steps：
S1,5.74 parts of polyvinylpyrrolidone PVP-K30 are added into stirring and dissolving in 102.24 parts of deionized waters, stirred 9 minutes,
Polyvinylpyrrolidone PVP-K30 solution for standby is made；0.37 part of sodium lactate, 0.88 part of potassium dihydrogen phosphate are added 29.21 parts
Stirring and dissolving in deionized water, stir 3 minutes, it is standby that solution A is made；
S2, under normal temperature, condition of normal pressure, 0.81 part of iodine is added in 2.94 parts of NPE TX-10, stirring 2.6
Hour, solution A is added, stirs 1.7 hours, obtains solution B；
S3, the solution B obtained in S2 added into S1 obtained polyvinylpyrrolidone with the speed of 3.7 parts by weight/minute
In PVP-K30 solution, stir 7.3 hours, add 0.20 part of triethanolamine, stir 0.9 hour, disinfectant tamed iodine is made.
Embodiment 9
A kind of preparation method of disinfectant tamed iodine provided by the invention, comprises the following steps：
S1,4.67 parts of polyvinylpyrrolidone PVP-K30 are added into stirring and dissolving in 113.38 parts of deionized waters, stirred 7 minutes,
Polyvinylpyrrolidone PVP-K30 solution for standby is made；0.49 part of sodium lactate, 0.57 part of potassium dihydrogen phosphate are added 29.84 parts
Stirring and dissolving in deionized water, stir 4.8 minutes, it is standby that solution A is made；
S2, under normal temperature, condition of normal pressure, 0.65 part of iodine is added in 3.38 parts of NPE TX-10, stirring 3.7
Hour, solution A is added, stirs 1.5 hours, obtains solution B；
S3, the solution B obtained in S2 added into S1 obtained polyvinylpyrrolidone with the speed of 3.1 parts by weight/minute
In PVP-K30 solution, stir 6.4 hours, add 0.31 part of triethanolamine, stir 0.6 hour, disinfectant tamed iodine is made.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (9)
1. a kind of disinfectant tamed iodine, it is characterised in that its raw material includes by weight：Iodine 0.6-1.0 parts, polyvinylpyrrolidone
4.5-7.0 parts, NPE 2.0-4.0 parts, sodium lactate 0.3-0.5 parts, potassium dihydrogen phosphate 0.5-1.2 parts, three second
Hydramine 0.1-0.4 parts, deionized water 110-150 parts.
2. a kind of disinfectant tamed iodine according to claim 1, it is characterised in that its raw material includes by weight：Iodine 0.7-
0.9 part, polyvinylpyrrolidone 4.8-6.0 parts, NPE 2.6-3.1 parts, sodium lactate 0.35-0.43 parts, phosphorus
Acid dihydride potassium 0.6-1.0 parts, triethanolamine 0.15-0.25 parts, deionized water 120-135 parts.
3. a kind of disinfectant tamed iodine according to claim 1, it is characterised in that its raw material includes by weight：Iodine 0.84
Part, 5.53 parts of polyvinylpyrrolidone, 2.81 parts of NPE, 0.39 part of sodium lactate, 0.76 part of potassium dihydrogen phosphate,
0.18 part of triethanolamine, 128.49 parts of deionized water.
4. a kind of disinfectant tamed iodine according to claim 1, it is characterised in that the polyvinylpyrrolidone is PVP-
K30。
5. a kind of disinfectant tamed iodine according to claim 1, it is characterised in that the NPE is TX-
10。
6. a kind of preparation method of disinfectant tamed iodine, it is characterised in that comprise the following steps：
S1, polyvinylpyrrolidone is added to stirring and dissolving in deionized water, stirring 6-10 minutes, obtained polyvinylpyrrolidone
Solution for standby；Sodium lactate, potassium dihydrogen phosphate are added into stirring and dissolving in deionized water, 3-5 minutes is stirred, it is standby that solution A is made；
S2, under normal temperature, condition of normal pressure, by iodine add NPE in, stir 2.5-4 hours, add solution
A, 1-2 hours are stirred, obtain solution B；
In S3, the polyvinylpyrrolidonesolution solution that will be obtained in the solution B obtained in S2 addition S1,6-8 hours are stirred, are added
Triethanolamine, 0.5-1 hours are stirred, disinfectant tamed iodine is made.
7. a kind of preparation method of disinfectant tamed iodine according to claim 6, it is characterised in that prepare polyethylene in the S1
Pyrrolidone solution is 3-4 with the weight ratio for preparing deionized water used in solution A:1.
8. a kind of preparation method of disinfectant tamed iodine according to claim 6, it is characterised in that prepare polyethylene in the S1
Pyrrolidone solution is 3.3 with the weight ratio for preparing deionized water used in solution A:1.
9. a kind of preparation method of disinfectant tamed iodine according to claim 6, it is characterised in that solution B adds in the S3
Speed in polyvinylpyrrolidonesolution solution is 3-4 parts by weight/minute.
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| CN201710937337.9A CN107468706A (en) | 2017-09-30 | 2017-09-30 | A kind of disinfectant tamed iodine and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114652899A (en) * | 2022-04-12 | 2022-06-24 | 深圳职业技术学院 | A self-growing artificial skin with antibacterial effect for burn, and its preparation method |
| CN118058298A (en) * | 2024-04-19 | 2024-05-24 | 四川大学华西医院 | Iodine-containing cleaning disinfectant for flushing endoscope lens in operation process and preparation method thereof |
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| CN101176700A (en) * | 2007-10-29 | 2008-05-14 | 广东庆发药业有限公司 | Antimicrobial disinfection hand cleanser and preparation method thereof |
| CN101785477A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | Polyoxyethylene nonyl phenyl ether iodine complex disinfecting solution and preparation method thereof |
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| CN106265729A (en) * | 2016-10-11 | 2017-01-04 | 重庆市普康消毒用品有限公司 | A kind of disinfectant tamed iodine |
| CN106386853A (en) * | 2016-08-30 | 2017-02-15 | 四川创美克科技有限公司 | Multi-effect active iodine disinfectant as well as preparation method and application thereof |
| CN106821974A (en) * | 2017-03-29 | 2017-06-13 | 佛山市南海东方澳龙制药有限公司 | The preparation method of Betagen Solution and the Betagen Solution prepared by the method |
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- 2017-09-30 CN CN201710937337.9A patent/CN107468706A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3911107A (en) * | 1972-12-18 | 1975-10-07 | Flow Pharma Inc | Iodine composition and dissipating solution |
| CN101176700A (en) * | 2007-10-29 | 2008-05-14 | 广东庆发药业有限公司 | Antimicrobial disinfection hand cleanser and preparation method thereof |
| CN101785477A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | Polyoxyethylene nonyl phenyl ether iodine complex disinfecting solution and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114652899A (en) * | 2022-04-12 | 2022-06-24 | 深圳职业技术学院 | A self-growing artificial skin with antibacterial effect for burn, and its preparation method |
| CN118058298A (en) * | 2024-04-19 | 2024-05-24 | 四川大学华西医院 | Iodine-containing cleaning disinfectant for flushing endoscope lens in operation process and preparation method thereof |
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