CN103238595B - Special concentrated type glutaraldehyde disinfectant for endoscopes and preparation method of special concentrated type glutaraldehyde disinfectant - Google Patents
Special concentrated type glutaraldehyde disinfectant for endoscopes and preparation method of special concentrated type glutaraldehyde disinfectant Download PDFInfo
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- CN103238595B CN103238595B CN201310153880.1A CN201310153880A CN103238595B CN 103238595 B CN103238595 B CN 103238595B CN 201310153880 A CN201310153880 A CN 201310153880A CN 103238595 B CN103238595 B CN 103238595B
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Abstract
The invention relates to a disinfectant, and more particularly relates to a special concentrated type glutaraldehyde disinfectant for endoscopes and a preparation method of the special concentrated type glutaraldehyde disinfectant. The special concentrated type glutaraldehyde disinfectant comprises the following raw materials in percentage by mass: 24%-25% of glutaraldehyde, 20%-30% of antioxidant penetrating agent, 5%-10% of non-ionic surface active agent, 0.5%-1.5% of complexing agent, 5%-10% of dissolving additive and the balance of deionized water. After the special concentrated type glutaraldehyde disinfectant is diluted, the percentage composition of the glutaraldehyde is only 0.25%-0.35% in the using process of the special concentrated type glutaraldehyde disinfectant, and the special concentrated type glutaraldehyde disinfectant is short in acting time and disposable; compared with the corrosivity of the disinfectant for the endoscopes in the prior art, the corrosivity of the special concentrated type glutaraldehyde disinfectant is reduced; simultaneously, the special concentrated type glutaraldehyde disinfectant can be matched with a full-automatic endoscope cleaning sterilizer for use and can be used for effectively killing bacterial spores under a relatively mild condition. Experiments prove that when the special concentrated type glutaraldehyde disinfectant is matched with the full-automatic endoscope cleaning sterilizer for use, the kill ratio of the special concentrated type glutaraldehyde disinfectant for spores of bacillus subtilis var niger is higher than or equal to 99.9%. The special concentrated type glutaraldehyde disinfectant can meet the using requirements of the full-automatic endoscope cleaning sterilizer.
Description
Technical field
The present invention relates to a kind of disinfectant, be specifically related to special concentrated type glutaraldehyde disinfectant of a kind of scope and preparation method thereof.
Background technology
Sterilizing endoscope glutaral disinfectant solution commercially available is at present generally 2% alkaline glutaric dialdehyde solution, and product is polynary packaging and needs activation in use procedure, and process is loaded down with trivial details, excitant is large, can not meet full-automatic endoscope cleaning-disinfection machine spray soaks use.Glutaraldehyde content more than 20%, the glutaral disinfectant solution that full-automatic endoscope cleaning-disinfection machine can be coordinated to use also did not meet relevant report.
The sterilizing mechanisms of glutaraldehyde mainly by the alkylating of two active aldehyde radicals, directly or indirectly acts on the different groups of bioprotein, makes it lose biologically active and cause microbial death, specific as follows:
1. directly act on bacterium protein and zymoprotein molecule, destroy peptide glycan, change protein molecular structure, make it lose original biologically active, Cell uptake dysbolism causes cell death.In addition, interlinkage reaction between aldehyde radical and protein, can be there is, cause cell wall to solidify, close, bacterial respiratory and Nutrition and Metabolism obstacle can also be affected, make bacterial death.
2. glutaraldehyde can make pyridinedicarboxylic acid release difficulty in bacterial spore skin, thus stops bacterial spore to sprout; Interlinkage effect simultaneously can be again that gemma wall is closed, and causes gemma and fungal spore death.
3. glutaraldehyde acts on microbial nucleic acids matter DNA or RNA, can suppress rapidly the synthesis of biomolecule, and can change the ordered state of biomolecule subunit, destroy the integrality of biomolecular structure, cause the death of microorganism.And the factor affecting glutaraldehyde bactericidal effect mainly contains concentration, temperature, pH value, organic matter etc., generally require that glutaraldehyde concentration is not less than 2%, but glutaraldehyde has certain imbedibility toxicity and respiratory mucosa excitant, in air, maximum permissible concentration is 0.05ppm.
The structural formula of glutaraldehyde is: CHO-CH
2cH
2cH
2-CHO, wherein CHO is sterilizing activity group.
Summary of the invention
The object of this invention is to provide special concentrated type glutaraldehyde disinfectant of a kind of scope and preparation method thereof, this product, without the need to activation, directly dilutes use, effectively reduces disinfectant for the toxicity of respiratory tract and excitant; Invention also provides its preparation method.
The special concentrated type glutaraldehyde disinfectant of scope of the present invention, be made up of the raw material of following mass percent:
Described anti-oxidant bleeding agent is the mixture of methyl alcohol, ethanol and isopropyl alcohol, and the mass ratio of methyl alcohol, ethanol, isopropyl alcohol is 1:2:2.
Described non-ionic surface active agent is block polyether, preferred Shanghai Chi Chen Industrial Co., Ltd. GALLOPEN CC29.
Described dissolution aids is functional many alcohol, 2-methyl-2,4-pentanediol, preferred Shanghai Suo Kai Industrial Co., Ltd. HEXASOL.
Described complexing agent is the mixture of salicylic acid and EDTA, and the mass ratio of salicylic acid, EDTA is 10:1.
Adopting water concentrated type glutaraldehyde disinfectant to be diluted to glutaraldehyde percentage composition during use is 0.25 ~ 0.35%.
The preparation method of described concentrated type glutaraldehyde scope appropriative disinfector, comprises the steps:
Be dissolved in by glutaraldehyde solution in deionized water, stir and make it be dissolved to clarification completely, then dissolution aids, anti-oxidant bleeding agent, non-ionic surface active agent, complexing agent are joined successively in above-mentioned solution, mixing rear pH value is 4 ~ 5, filling obtained finished product.
The present invention has following features:
(1) adopt senaside, use procedure without the need to activation, namely without the need to adding preservative and adjust ph; The present invention directly can dilute use (namely adopting unitary packaging, composite without the need to being carried out in use by several material), can kill gemma;
(2) traditional glutaral disinfectant solution generally adds poly alkyl alcohol oxyethanol ether and is used for increasing effect as surfactant, but after adding poly alkyl alcohol oxyethanol ether in the present invention, because severe blister causes full-automatic endoscope cleaning-disinfection machine not use, and rinsing is not thorough; The present invention adopts block polyether, shows as sterilization and works in coordination with and low bubble.
(3) certainty ratio of complexing agent and anti-oxidant bleeding agent (methyl alcohol, ethanol and isopropyl alcohol) adds bubble not only can be suppressed to produce, and improves cell permeability, serves collaborative bactericidal action, enhances the stability of product simultaneously.Sterilising conditions of the present invention is that in prior art, any one commercially available glutaraldehyde disinfectant is beyond one's reach.
In order to change the glutaraldehyde disinfectant problem such as concentration and transport in use, we have developed this novel concentrated type glutaraldehyde scope appropriative disinfector.The great advantage of this disinfectant can coordinate full-automatic endoscope cleaning-disinfection machine to use exactly.During use, adopt water to carry out diluting (after dilution, glutaraldehyde percentage composition is generally 0.25 ~ 0.35%), use the content reducing glutaraldehyde in scope disinfectant in the past after dilution, effectively reduce respiratory tract imbedibility toxicity and excitant.Add the non-ionic surface active agent block polyether of stoichiometric, block polyether molecule can be adsorbed onto bacterial body surface simultaneously, changes cell permeability, bactericidal action shows as synergy, and the low bubble of product, be easy to rinsing.The oxidation that the adding of quantitative short chain alcohol (methyl alcohol, ethanol) effectively can prevent glutaraldehyde thus strengthen the self stability of solution, simultaneously ethanol can strengthen Premeabilisation of cells, strengthens glutaraldehyde to the killing effect of microorganism and enhances the Disinfection Effect of thimerosal; Quantitative isopropyl alcohol add the foaming phenomena that can effectively suppress in rinse cycle, ensure that the completeness of rinsing; Quantitative complexing agent add the staining reaction effectively can alleviating glutaraldehyde.As known from the above, the present invention has played good Synergistic biocidal effect and using function.
Beneficial effect of the present invention is as follows:
In disinfectant dilution use procedure of the present invention, glutaraldehyde percentage composition is only 0.25 ~ 0.35%, action time short and single use, reduce the corrosivity of sterilizing endoscope agent of the prior art, full-automatic endoscope cleaning-disinfection machine can be coordinated to use simultaneously, can under relatively mild condition, effective kill bacteria gemma.
Experiment prove, when coordinating full-automatic endoscope cleaning-disinfection machine to use, the present invention 44 ~ 46 DEG C, time 5min, flushing soaking disinfection condition under, for black hay bacillus mutation gemma killing rate >=99.9%; Can meet and coordinate full-automatic endoscope cleaning-disinfection machine instructions for use.
Embodiment
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1
The preparation method of the special concentrated type glutaraldehyde disinfectant of described scope, comprises the steps:
50% glutaraldehyde water solution 500g is dissolved in deionized water, stirring makes it be dissolved to clarification completely, again dissolution aids 75g, short chain alcohol (methyl alcohol, ethanol and isopropyl alcohol) 200g, block polyether 100g, salicylic acid and EDTA10g are joined in above-mentioned solution successively, add deionized water to 1kg, mixing rear pH value is 4 ~ 5, filling obtained finished product.
Embodiment 2
The preparation method of the special concentrated type glutaraldehyde disinfectant of described scope, comprises the steps:
50% glutaraldehyde water solution 500g is dissolved in deionized water, stirring makes it be dissolved to clarification completely, again dissolution aids 75g, short chain alcohol (methyl alcohol, ethanol and isopropyl alcohol) 300g, block polyether 50g, salicylic acid and EDTA10g are joined in above-mentioned solution successively, add deionized water to 1kg, mixing rear pH value is 4 ~ 5, filling obtained finished product.
Embodiment 3
The preparation method of the special concentrated type glutaraldehyde disinfectant of described scope, comprises the steps:
50% glutaraldehyde water solution 500g is dissolved in deionized water, stirring makes it be dissolved to clarification completely, again dissolution aids 75g, short chain alcohol (methyl alcohol, ethanol and isopropyl alcohol) 250g, block polyether 75g, salicylic acid and EDTA10g are joined in above-mentioned solution successively, add deionized water to 1kg, mixing rear pH value is 4 ~ 5, filling obtained finished product.
Embodiment 4
The preparation method of the special concentrated type glutaraldehyde disinfectant of described scope, comprises the steps:
50% glutaraldehyde water solution 500g is dissolved in deionized water, stirring makes it be dissolved to clarification completely, again dissolution aids 50g, short chain alcohol (methyl alcohol, ethanol and isopropyl alcohol) 200g, block polyether 50g, salicylic acid and EDTA10g are joined in above-mentioned solution successively, add deionized water to 1kg, mixing rear pH value is 4 ~ 5, filling obtained finished product.
Embodiment 5
The preparation method of the special concentrated type glutaraldehyde disinfectant of described scope, comprises the steps:
50% glutaraldehyde water solution 500g is dissolved in deionized water, stirring makes it be dissolved to clarification completely, again dissolution aids 50g, short chain alcohol (methyl alcohol, ethanol and isopropyl alcohol) 300g, block polyether 100g, salicylic acid and EDTA10g are joined in above-mentioned solution successively, add deionized water to 1kg, mixing rear pH value is 4 ~ 5, filling obtained finished product.
The mass ratio of the methyl alcohol described in embodiment 1-5, ethanol, isopropyl alcohol is 1:2:2.
Described block polyether is Shanghai Chi Chen Industrial Co., Ltd. GALLOPEN CC29.
Described dissolution aids is functional many alcohol, is Shanghai Suo Kai Industrial Co., Ltd. HEXASOL.
Described salicylic acid, the mass ratio of EDTA are 10:1.
The product obtained by embodiment 1-5, adopts deionized water to dilute with the mass ratio of 1:100, tests under full-automatic endoscope cleaning-disinfection machine standardization program.Full-automatic endoscope cleaning-disinfection machine standardization program is that prerinse-cleaning-enzyme washes-rinsing-sterilization-three times rinsing-drying.Wherein, disinfectant program be 44 ~ 46 DEG C, disinfecting time 5min, rinse soaking disinfection condition under carry out, Disinfection Effect is as shown in table 1 below:
Table 1 bactericidal effect table
From data in table 1, use the present invention, at 44 ~ 46 DEG C, flushing soaking disinfection 5min, the high sterilisation level of medicine equipment can be reached.
Claims (1)
1. the special concentrated type glutaraldehyde disinfectant of scope, is characterized in that being made up of the raw material of following mass percent:
Glutaraldehyde 24 ~ 25%
Anti-oxidant bleeding agent 20 ~ 30%
Non-ionic surface active agent 5 ~ 10%
Complexing agent 0.5 ~ 1.5%
Dissolution aids 5 ~ 10%
Deionized water surplus;
Anti-oxidant bleeding agent is the mixture of methyl alcohol, ethanol and isopropyl alcohol, and the mass ratio of methyl alcohol, ethanol, isopropyl alcohol is 1:2:2;
Non-ionic surface active agent is block polyether, is selected from Shanghai Chi Chen Industrial Co., Ltd. GALLOPEN CC 29;
Complexing agent is the mixture of salicylic acid and EDTA, and the mass ratio of salicylic acid, EDTA is 10:1;
Dissolution aids is 2-methyl-2,4-pentanediol;
Adopting water concentrated type glutaraldehyde disinfectant to be diluted to glutaraldehyde percentage composition during use is 0.25 ~ 0.35%;
The preparation method of the special concentrated type glutaraldehyde disinfectant of described scope, comprises the steps:
Glutaraldehyde solution is dissolved in deionized water, stirring makes it be dissolved to clarification completely, dissolution aids, anti-oxidant bleeding agent, non-ionic surface active agent, complexing agent are joined successively in above-mentioned solution, mixing rear pH value is 4 ~ 5, filling obtained finished product again.
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| CN201310153880.1A CN103238595B (en) | 2013-04-28 | 2013-04-28 | Special concentrated type glutaraldehyde disinfectant for endoscopes and preparation method of special concentrated type glutaraldehyde disinfectant |
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| CN201310153880.1A CN103238595B (en) | 2013-04-28 | 2013-04-28 | Special concentrated type glutaraldehyde disinfectant for endoscopes and preparation method of special concentrated type glutaraldehyde disinfectant |
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| CN103238595B true CN103238595B (en) | 2015-02-18 |
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| CN110934137A (en) * | 2018-09-21 | 2020-03-31 | 上海利康消毒高科技有限公司 | Composite glutaraldehyde disinfectant and preparation method thereof |
| CN112931502A (en) * | 2019-12-11 | 2021-06-11 | 山东菏泽三仪生物工程有限公司 | Compound glutaraldehyde reinforced disinfectant and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4748279A (en) * | 1986-06-27 | 1988-05-31 | Whiteley Reginald K | Liquid sterilizing composition |
| US6525101B2 (en) * | 1996-11-01 | 2003-02-25 | Reginald Keith Whiteley | Ready-to-use glutaraldehyde concentrates |
| CN101238816A (en) * | 2007-02-06 | 2008-08-13 | 上海利康消毒高科技有限公司 | Single-component activation pentanedial disinfecting agent and preparation thereof |
| CN101932342A (en) * | 2007-03-28 | 2010-12-29 | 怀特利集团控股有限公司 | Sterilizing composition |
-
2013
- 2013-04-28 CN CN201310153880.1A patent/CN103238595B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4748279A (en) * | 1986-06-27 | 1988-05-31 | Whiteley Reginald K | Liquid sterilizing composition |
| US6525101B2 (en) * | 1996-11-01 | 2003-02-25 | Reginald Keith Whiteley | Ready-to-use glutaraldehyde concentrates |
| CN101238816A (en) * | 2007-02-06 | 2008-08-13 | 上海利康消毒高科技有限公司 | Single-component activation pentanedial disinfecting agent and preparation thereof |
| CN101932342A (en) * | 2007-03-28 | 2010-12-29 | 怀特利集团控股有限公司 | Sterilizing composition |
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