CN108552173A - A kind of compound ortho-phthalaldehyde bactericidal agent and preparation method thereof - Google Patents
A kind of compound ortho-phthalaldehyde bactericidal agent and preparation method thereof Download PDFInfo
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- CN108552173A CN108552173A CN201810730647.8A CN201810730647A CN108552173A CN 108552173 A CN108552173 A CN 108552173A CN 201810730647 A CN201810730647 A CN 201810730647A CN 108552173 A CN108552173 A CN 108552173A
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- phthalaldehyde
- bactericidal agent
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
Abstract
The present invention provides a kind of compound ortho-phthalaldehyde bactericidal agents, science compounding is carried out by the components such as o-phthalaldehyde and bleeding agent and quaternary ammonium disinfectant, it highly shortened the time for killing gemma, the killing rate of bacillus subtilis black variety gemma is sterilized up to absolutely, satisfaction is medical to timeliness, the requirements at the higher level of safety；And product with stable quality, 37 DEG C, O-phthalic aldehyde average rate of decrease is no more than 5.26% after 90d；Substantially it has no irritating odor, it is substantially non-corrosive to metal, it is not damaged to instrument；Grey dye problem is avoided, using more convenient, safe and reliable.
Description
Technical field
The present invention relates to disinfectant technical field more particularly to a kind of compound ortho-phthalaldehyde bactericidal agent and its preparation sides
Method.
Background technology
O-phthalaldehyde has substantially non-stimulated gas as a kind of new and effective disinfectant, more traditional glutaraldehyde disinfectant
The advantages that taste, low toxicity, activity are low, service life is long, high-efficiency broad spectrum, low corrosion, in the disinfection especially soft scope in field
It is widely used in terms of disinfection.
However, existing O-phthalaldehyde disinfectant is faced with various problems in use：
1) effect for killing bacillus subtilis black variety gemma is faint, and 0.5% o-phthalaldehyde acts on it 10h, only
Kill 0.05log；
2) o-phthalaldehyde all has a degree of corrosivity to metals such as copper, aluminium, carbon steels；
3) o-phthalaldehyde is oxidizable to light and air-sensitive, oxidizable after being compounded with other raw materials, the term of validity is short；
4) o-phthalaldehyde is due to making protein fast denaturation, and unique colorization tips is shown after protein contacts
(it is commonly called as " ash dye ", it is light that " ash dye " phenomenon shows that the positions such as sink, metope, operating table surface, operating personnel's skin and fabric occur
Spot, the trace of grey, the ash that the different depths are will produce to unlike material contaminate), automatic endoscope cleaning machine can be made to colour.
Therefore, exploitation is a kind of can be achieved at the same time compound neighbour's benzene that sterilized, corrosivity is low, ashless dye and property are stablized
Dicarbaldehyde sterilizes liquid product, has great importance.
Invention content
The purpose of the present invention is to provide a kind of compound ortho-phthalaldehyde bactericidal agent, compound O-phthalic provided by the invention
Aldehyde bactericidal agent has the characteristics that sterilized, ashless dye, property stabilization and low corrosion.
In order to achieve the above-mentioned object of the invention, the present invention provides following technical scheme：
The present invention provides a kind of compound ortho-phthalaldehyde bactericidal agents, include the component of following mass fraction：
O-phthalaldehyde 0.3~10%, alcohol disinfectant 8~25%, quaternary ammonium disinfectant 0.2~5.0%, bleeding agent
0.5~10%, cosolvent 0.5~10%, corrosion inhibiter 0.2~5.0%, stabilizer 0.2~6.0%, pH adjusting agent 0.5~
12%, surplus is water.
Preferably, the alcohol disinfectant is ethyl alcohol, ethylene glycol, isopropanol or butanediol；The quaternary ammonium disinfectant
For benzalkonium chloride, benzalkonium bromide, double-chain quaternary ammonium salt or polyquaternium.
Preferably, the bleeding agent be poly alkyl alcohol oxyalkyl ether compound, disecoctylmaleate sodium sulfonate,
It is one or more in dimethyl sulfoxide (DMSO), azone and thiophene ketone.
Preferably, the cosolvent is one or more in glycerine, propylene glycol and polyethylene glycol.
Preferably, the corrosion inhibiter is sodium metasilicate, sodium molybdate, phytic acid, benzotriazole, borate ester, polyethylene glycol, season
It is one or more in penta tetrol, calgon and sodium polyphosphate.
Preferably, the stabilizer includes chelating agent and antioxidant；The chelating agent is sodium ethylene diamine tetracetate, lemon
One or several kinds in acid, phytic acid, maltonic acid sodium, inorganic phosphate, organic phosphoric acid and organic phosphate；The antioxygen
Agent is one or more in ascorbyl palmitate, tert-butylhydroquinone and 2,6 di tert butyl 4 methyl phenol.
Preferably, the pH adjusting agent is inorganic strong alkali, carbonate, bicarbonate, boric acid, borax, potassium dihydrogen phosphate
With it is one or more in disodium hydrogen phosphate.
Preferably, the pH value of the compound ortho-phthalaldehyde bactericidal agent is 7.5~9.0.
The present invention provides the preparation methods of compound ortho-phthalaldehyde bactericidal agent described in above-mentioned technical proposal, including following step
Suddenly：
In a heated condition, part water is mixed with o-phthalaldehyde, cosolvent and stabilizer, stops heating, obtain the
One mixed liquor；
First mixed liquor is mixed with alcohol disinfectant, quaternary ammonium disinfectant, bleeding agent and corrosion inhibiter, obtains
Two mixed liquors；
Second mixed liquor is mixed with pH adjusting agent and remaining water, obtains compound ortho-phthalaldehyde bactericidal agent.
The present invention provides a kind of compound ortho-phthalaldehyde bactericidal agent, the present invention is by o-phthalaldehyde and bleeding agent and season
The components such as ammonium salt class disinfectant carry out science compounding, the time for killing gemma are highly shortened, to bacillus subtilis var
The killing rate of gemma is up to absolutely, and satisfaction medical treatment disinfection is to timeliness, the requirements at the higher level of safety；
The present invention enhances the inoxidizability of o-phthalaldehyde bactericidal agent and anti-gold by adding chelating agent and antioxidant
Belong to ion interference, product with stable quality, 14 days contents of continuous use are still 0.3% or more；
The present invention o-phthalaldehyde bactericidal agent have no irritating odor substantially, it is substantially non-corrosive to metal, to instrument without
Damage；
The o-phthalaldehyde bactericidal agent non-foam of the present invention can meet the needs of machine washing disinfection, avoid grey dye problem,
Using more convenient, safe and reliable.
Specific implementation mode
The present invention provides a kind of compound ortho-phthalaldehyde bactericidal agents, include the component of following mass fraction：
O-phthalaldehyde 0.3~10%, alcohol disinfectant 8~25%, quaternary ammonium disinfectant 0.2~5.0%, bleeding agent
0.5~10%, cosolvent 0.5~10%, corrosion inhibiter 0.2~5.0%, stabilizer 0.2~6.0%, pH adjusting agent 0.5~
12%, surplus is water.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention includes the o-phthalaldehyde that mass fraction is 0.3~10%,
Preferably 1.0~8.0%, more preferably 3.0~5.0%.The present invention is sent out using the aldehyde radical of o-phthalaldehyde with amino acid group
Raw cross-linking reaction, and penetrated into containing the more substance of lipid, such as cell membrane, Jin Ershi using the special efficacy of its aromatic hydrocarbon having
Existing bactericidal effect.The present invention does not have the source of the o-phthalaldehyde special limitation, selects those skilled in the art known
The o-phthalaldehyde in source.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention includes the alcohol disinfectant that mass fraction is 8~25%, excellent
It is selected as 10%.In the present invention, the alcohol disinfectant is preferably small molecule alcohol disinfectant, it is specific such as ethyl alcohol, it is ethylene glycol, different
Propyl alcohol or butanediol.The present invention plays the role of sterilization infiltration using alcohol disinfectant, inhibits foam.The present invention is to the alcohols
The source of disinfectant does not have special restriction, selects the mentioned component in the known source of those skilled in the art.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention includes that the quaternary ammonium salt that mass fraction is 0.2~5.0% disappears
Toxic agent, preferably 0.3%.In the present invention, the quaternary ammonium disinfectant is preferably benzalkonium chloride, benzalkonium bromide, double-strand season
Ammonium salt or polyquaternium.The present invention is using quaternary ammonium disinfectant as assisting sterilisation ingredient, with good surface-active,
Can high concentration live in concentrated communities in phage surface, hinder its metabolism；Osmotic pressure, the membrane permeability for changing cell, make outside thalline endochylema substance
It oozes, it is hindered to be metabolized and play killing effect；Make protein denaturation, inhibit certain enzymatic activitys in bacterial body, and plays killing effect；Together
When can also play the role of reduce ash dye.The present invention does not have the source of the quaternary ammonium disinfectant special restriction, selects
The mentioned component in the known source of those skilled in the art.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention includes the bleeding agent that mass fraction is 0.5~10%, preferably
It is 1.0~8.0%, more preferably 3.0~6.0%.In the present invention, the bleeding agent is preferably poly alkyl alcohol oxyalkyl ethers
Compound (SF bleeding agents), disecoctylmaleate sodium sulfonate, dimethyl sulfoxide (DMSO), azone and one kind in thiophene ketone or
It is a variety of.The present invention utilizes the strength Penetration enhancing effect of bleeding agent, strengthen quaternary ammonium salt and o-phthalaldehyde to the attachment of gemma, hold
It stays, soak, spread, osmosis, that is, increasing their contact angles to spore surface, changing gemma knot using its osmosis
Structure promotes killing effect of the o-phthalaldehyde to gemma, and product is made to realize 30min sterilizings.The present invention is to the bleeding agent
Source there is no a special restriction, select the mentioned component in the known source of those skilled in the art.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention includes the cosolvent that mass fraction is 0.5~10%, preferably
It is 2~8%, more preferably 4~6%.In the present invention, the cosolvent is preferably in glycerine, propylene glycol and polyethylene glycol
It is one or more；The molecular weight of the polyethylene glycol is preferably 200~600.The present invention accelerates o-phthalaldehyde using cosolvent
With the solution rate of other compositions, avoids stirring and heating for a long time, reduce the loss of effective content and reduce energy consumption, improve
Production efficiency.The present invention does not have the source of the cosolvent special restriction, selects the known source of those skilled in the art
Mentioned component.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention includes the corrosion inhibiter that mass fraction is 0.2~5.0%, preferably
It is 1.0~4.0%, more preferably 2.0~3.0%.In the present invention, the corrosion inhibiter is preferably sodium metasilicate, sodium molybdate, plant
One kind or more in acid, benzotriazole, borate ester, polyethylene glycol, pentaerythrite, calgon and sodium polyphosphate
Kind.The present invention reduces o-phthalaldehyde and quaternary ammonium salt to corrosivity such as copper aluminium carbon steels using corrosion inhibiter, the present invention from
Compatibility, inhibition degree and cost angle consider, select respectively to copper, aluminium, the significant corrosion inhibiter of carbon steel corrosion mitigating effect into
Row compounding, is realized substantially non-corrosive to metal.The present invention does not have the source of the corrosion inhibiter special restriction, selects ability
The mentioned component in the known source of field technique personnel.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention includes the stabilizer that mass fraction is 0.2~6.0%, preferably
It is 1.0~5.0%, more preferably 2.0~4.0%.In the present invention, the stabilizer preferably includes chelating agent and anti-oxidant
Agent；The chelating agent is preferably disodium ethylene diamine tetraacetate, citric acid, phytic acid, maltonic acid sodium, inorganic phosphate, organic
One or several kinds in phosphoric acid and organic phosphate；The antioxidant is preferably ascorbyl palmitate, tertiary butyl pair
It is one or more in benzenediol and 2,6 di tert butyl 4 methyl phenol.The present invention enhances O-phthalic using stabilizer
The inoxidizability and anti-metal ion interference of aldehyde bactericidal agent, effectively delay the oxidation of o-phthalaldehyde so that product quality is steady
It is fixed.The present invention does not have the source of the stabilizer a special restriction, select the known source of those skilled in the art it is above-mentioned at
Point.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention includes the pH adjusting agent that mass fraction is 0.5~12%,
Preferably 2.0~10%, more preferably 5.0~8.0%.In the present invention, the pH adjusting agent is preferably inorganic strong alkali, carbon
It is one or more in hydrochlorate, bicarbonate, boric acid, borax, potassium dihydrogen phosphate and disodium hydrogen phosphate.
In the present invention, the pH value of the compound ortho-phthalaldehyde bactericidal agent is preferably 7.5~9.0.The compound of the present invention
O-phthalaldehyde bactericidal agent belongs to alkaline bactericidal agent, and under alkaline condition, the bactericidal activity of o-phthalaldehyde and quaternary ammonium salt is all aobvious
It writes and improves, and the enhancing of alkalinity can accelerate reacting between o-phthalaldehyde and lysine, glycine and histidine；Exist simultaneously
Under alkaline condition, OH-Proton exchange can occur with the amino in bacterio protein upper amino acid group to react, increase ion
The ratio of state amino, to provide the more group with O-phthalic aldehyde reaction；In addition, under alkaline condition, can cause
Separation between bacillus subtilis black variety gemma shell and cortex, it is easier to which bactericidal agent, which penetrates into gemma, plays sterilization work
With.The present invention does not have the source of the pH adjusting agent special restriction, selects the upper of the known source of those skilled in the art
State ingredient.
The present invention provides the preparation methods of compound ortho-phthalaldehyde bactericidal agent described in above-mentioned technical proposal, including following step
Suddenly：
In a heated condition, part water is mixed with o-phthalaldehyde, cosolvent and stabilizer, stops heating, obtain the
One mixed liquor；
First mixed liquor is mixed with alcohol disinfectant, quaternary ammonium disinfectant, bleeding agent and corrosion inhibiter, obtains
Two mixed liquors；
Second mixed liquor is mixed with pH adjusting agent and remaining water, obtains compound ortho-phthalaldehyde bactericidal agent.
The present invention is mixed with o-phthalaldehyde, cosolvent and stabilizer in a heated condition, by part water, stops heating,
Obtain the first mixed liquor.In the present invention, the temperature of the heating condition is preferably 45~55 DEG C.The present invention is preferably in stirring bar
The mixing is carried out under part, the rotating speed of the stirring is preferably 150~250rpm.The present invention is preferably first by part water and chelating agent
Mixing, then sequentially adds o-phthalaldehyde, cosolvent and antioxidant in gained mixed liquor.
After obtaining the first mixed liquor, the present invention by first mixed liquor and alcohol disinfectant, quaternary ammonium disinfectant, ooze
Saturating agent and corrosion inhibiter mixing, obtain the second mixed liquor.The present invention preferably sequentially adds the alcohols disinfection in the first mixed liquor
Agent, quaternary ammonium disinfectant, bleeding agent and corrosion inhibiter.The present invention preferably carries out the mixing, the stirring under agitation
Condition with prepare the condition of the first mixed liquor it is identical.
After obtaining the second mixed liquor, the present invention mixes second mixed liquor with pH adjusting agent and remaining water, is answered
Square o-phthalaldehyde bactericidal agent.The present invention preferably carries out the mixing under agitation, the condition of the stirring with prepare the
The condition of one mixed liquor is identical.The present invention preferably first mixes the second mixed liquor with pH adjusting agent, then in gained mixed liquor
Remaining water mixing is added.After remaining water is added, the present invention preferably stands gained mixed liquor, obtains compound ortho-phthalaldehyde
Bactericidal agent.In the present invention, the time of the standing is preferably 1.5~2.5h.The present invention ensures that mixed liquor is each by standing
Component is evenly dispersed, product stable homogeneous.In the present invention, the volume ratio of the part water and remaining water is preferably 1:1.8~
2.2, more preferably 1:2.
Compound ortho-phthalaldehyde bactericidal agent provided by the invention is described in detail with reference to embodiment, but not
They can be interpreted as limiting the scope of the present invention.
Embodiment 1
The formula of the present embodiment is：O-phthalaldehyde 10g；Ethyl alcohol 100g；Benzalkonium chloride 3g；Bleeding agent：SF bleeding agents
10g；Cosolvent：Polyethylene glycol-400 6g；Corrosion inhibiter：Sodium metasilicate 0.5g, sodium molybdate 0.6g, benzotriazole 0.5g；Stabilizer：
Disodium ethylene diamine tetraacetate 3g, ascorbyl palmitate 0.1g；PH adjusting agent：Potassium dihydrogen phosphate 0.1g, disodium hydrogen phosphate
9.3g；Water 856.9g.
Above-mentioned formula is prepared into compound ortho-phthalaldehyde bactericidal agent according to following technological process：
Agitator tank is added in the water of total amount 1/3, opens heating and stirring, control mixing speed is 200rpm, controls water temperature
It is 50 DEG C, chelating agent is added and stirs to dissolving；It sequentially adds o-phthalaldehyde, cosolvent and antioxidant to stir to dissolving, stop
It only heats, obtains the first mixed solution；
Alcohol disinfectant, quaternary ammonium disinfectant, bleeding agent and corrosion inhibiter are sequentially added into first mixed liquor, is stirred
It mixes to mixing well, obtains the second mixed liquor；
Potassium dihydrogen phosphate, stirring to dissolving are added into second mixed liquor；Then disodium hydrogen phosphate is added, stirring is extremely
Dissolving, adds the water of surplus, and stirring stands 2h, obtain compound ortho-phthalaldehyde bactericidal agent to mixing well.
Embodiment 2
According to technological process described in embodiment 1, compound ortho-phthalaldehyde bactericidal agent is prepared according to the following formulation：
O-phthalaldehyde 10g；Ethyl alcohol 100g；Benzalkonium chloride 1g；Double decyl dimethyl ammonium bromide 1.5g；Bleeding agent：SF oozes
Saturating agent 10g；Cosolvent：Polyethylene glycol-400 6g；Corrosion inhibiter：Sodium metasilicate 0.5g, sodium molybdate 0.6g, benzotriazole 0.5g；Surely
Determine agent：Disodium ethylene diamine tetraacetate 3g, ascorbyl palmitate 0.1g；PH adjusting agent：Potassium dihydrogen phosphate 0.1g, phosphoric acid hydrogen
Disodium 9.3g；Water 857.4g.
Embodiment 3
According to technological process described in embodiment 1, compound ortho-phthalaldehyde bactericidal agent is prepared according to the following formulation：
O-phthalaldehyde 10g；Isopropanol 100g；Benzalkonium chloride 3g；Bleeding agent：SF bleeding agents 10g；Cosolvent：Poly- second two
Alcohol -4006g；Corrosion inhibiter：Sodium metasilicate 0.5g, sodium molybdate 0.6g, benzotriazole 0.5g；Stabilizer：Disodium ethylene diamine tetraacetate
3g, ascorbyl palmitate 0.1g；PH adjusting agent：Potassium dihydrogen phosphate 0.1g, disodium hydrogen phosphate 9.3g；Water 856.9g.
Comparative example
According to technological process described in embodiment 1, compound ortho-phthalaldehyde bactericidal agent is prepared according to the following formulation：
O-phthalaldehyde 10g；Ethyl alcohol 60g；Bleeding agent：SF bleeding agents 10g；Cosolvent：Polyethylene glycol-400 6g；Inhibition
Agent：Sodium metasilicate 0.5g, sodium molybdate 0.6g, benzotriazole 0.5g；Stabilizer：Disodium ethylene diamine tetraacetate 3g, ascorbic acid palm fibre
Glycerin monostearate 0.1g；PH adjusting agent：Potassium dihydrogen phosphate 0.1g, disodium hydrogen phosphate 9.3g；Water 899.9g.
Embodiment 4
According to version in 2002《Disinfection technology standard》Sterile products inspection technology specification, to Examples 1 to 3 and comparative example institute
Disinfection Effect, product stability, the metal protection for obtaining compound ortho-phthalaldehyde bactericidal agent are measured.
Measurement result shows：
The compound ortho-phthalaldehyde bactericidal agent effect 30min of the present invention can kill hay bacillus black on haemostatic clamp and become completely
Kind gemma (positive control average production bacterium number：1.67 × 106/ samples), reach sterilizing and requires；
37 DEG C of accelerated experimental method, O-phthalic aldehyde average rate of decrease is no more than 5.26% after 90d, (the term of validity
It is 24 months), illustrate that the product property of the compound ortho-phthalaldehyde bactericidal agent of the present invention is stablized；
Metal protection to stainless steel, carbon steel, copper, aluminium is no corrosion degree, shows that the compound of the present invention is adjacent
Phthalaldehyde bactericidal agent can break through use scope and the field of O-phthalaldehyde disinfectant；
The cotton of 15x15cm sizes diluted milk is impregnated 5 minutes, after simple cleaning, immerse respectively embodiment 1~
It swings back and forth and rinses in the 3 compound ortho-phthalaldehyde bactericidal agents prepared, visually observe and judge its ash dye phenomenon, find the present invention's
Compound ortho-phthalaldehyde bactericidal agent is not likely to produce ash dye phenomenon.
The embodiment of the present invention is compared with comparative example it is found that without addition quaternary ammonium disinfectant in comparative example,
Obtained bactericidal agent effect 30min can not realize sterilizing, and there have in the presence of dirt ash contaminate phenomenon to be serious, and the embodiment of the present invention 1
~3 gained bactericidal agents are used in compounding the components such as o-phthalaldehyde and quaternary ammonium disinfectant, it can be achieved that quick sterilization, and ashless
Contaminate phenomenon.
As seen from the above embodiment, the present invention provides a kind of compound ortho-phthalaldehyde bactericidal agent, pass through o-phthalaldehyde
Science compounding is carried out with components such as bleeding agent and quaternary ammonium disinfectants, the time for killing gemma is highly shortened, to withered
The killing rate of straw bacterium var. niger spores is up to absolutely, and satisfaction medical treatment disinfection is to timeliness, the requirements at the higher level of safety；And
And product with stable quality, 37 DEG C, O-phthalic aldehyde average rate of decrease is no more than 5.26% after 90d；Substantially nonirritant
Smell, it is substantially non-corrosive to metal, it is not damaged to instrument；Grey dye problem is avoided, using more convenient, safe and reliable.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (9)
1. a kind of compound ortho-phthalaldehyde bactericidal agent, includes the component of following mass fraction：
O-phthalaldehyde 0.3~10%, alcohol disinfectant 8~25%, quaternary ammonium disinfectant 0.2~5.0%, bleeding agent 0.5
~10%, cosolvent 0.5~10%, corrosion inhibiter 0.2~5.0%, stabilizer 0.2~6.0%, pH adjusting agent 0.5~12%,
Surplus is water.
2. compound ortho-phthalaldehyde bactericidal agent according to claim 1, which is characterized in that the alcohol disinfectant is second
Alcohol, ethylene glycol, isopropanol or butanediol；The quaternary ammonium disinfectant is benzalkonium chloride, benzalkonium bromide, double-chain quaternary ammonium salt or poly-
Quaternary ammonium salt.
3. compound ortho-phthalaldehyde bactericidal agent according to claim 1, which is characterized in that the bleeding agent is poly alkyl alcohol
Oxyalkyl ether compound, disecoctylmaleate sodium sulfonate, dimethyl sulfoxide (DMSO), azone and one kind in thiophene ketone or
It is a variety of.
4. compound ortho-phthalaldehyde bactericidal agent according to claim 1, which is characterized in that the cosolvent is glycerine, third
It is one or more in glycol and polyethylene glycol.
5. compound ortho-phthalaldehyde bactericidal agent according to claim 1, which is characterized in that the corrosion inhibiter be sodium metasilicate,
In sodium molybdate, phytic acid, benzotriazole, borate ester, polyethylene glycol, pentaerythrite, calgon and sodium polyphosphate
It is one or more.
6. compound ortho-phthalaldehyde bactericidal agent according to claim 1, which is characterized in that the stabilizer includes chelating agent
And antioxidant；The chelating agent is sodium ethylene diamine tetracetate, citric acid, phytic acid, maltonic acid sodium, inorganic phosphate, has
One or several kinds in machine phosphoric acid and organic phosphate；The antioxidant is ascorbyl palmitate, tertiary butyl to benzene
It is one or more in diphenol and 2,6 di tert butyl 4 methyl phenol.
7. compound ortho-phthalaldehyde bactericidal agent according to claim 1, which is characterized in that the pH adjusting agent is inorganic
It is one or more in highly basic, carbonate, bicarbonate, boric acid, borax, potassium dihydrogen phosphate and disodium hydrogen phosphate.
8. compound ortho-phthalaldehyde bactericidal agent according to claim 1, which is characterized in that the compound ortho-phthalaldehyde goes out
The pH value of microbial inoculum is 7.5~9.0.
9. the preparation method of any one of the claim 1~8 compound ortho-phthalaldehyde bactericidal agent, includes the following steps：
In a heated condition, part water is mixed with o-phthalaldehyde, cosolvent and stabilizer, stops heating, it is mixed to obtain first
Close liquid；
First mixed liquor is mixed with alcohol disinfectant, quaternary ammonium disinfectant, bleeding agent and corrosion inhibiter, it is mixed to obtain second
Close liquid；
Second mixed liquor is mixed with pH adjusting agent and remaining water, obtains compound ortho-phthalaldehyde bactericidal agent.
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Cited By (3)
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| WO2020096890A1 (en) | 2018-11-05 | 2020-05-14 | Medivators Inc. | Composition for cleaning and assessing cleanliness in real-time |
| CN111436430A (en) * | 2020-05-20 | 2020-07-24 | 佳木斯大学 | Digestive endoscope disinfectant and preparation method thereof |
| CN112931505A (en) * | 2021-01-22 | 2021-06-11 | 海韵一剑大卫生科技有限公司 | Phthalic dicarboxaldehyde disinfectant, preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103960236A (en) * | 2013-11-19 | 2014-08-06 | 中国人民解放军疾病预防控制所 | OPA (ortho-phthalaldehyde)-containing compound disinfectant as well as preparation method and application thereof |
| CN105379712A (en) * | 2015-12-15 | 2016-03-09 | 山东消博士消毒科技股份有限公司 | Phthalic dicarboxaldehyde disinfectant for endoscope cleaning and preparation technology thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103960236A (en) * | 2013-11-19 | 2014-08-06 | 中国人民解放军疾病预防控制所 | OPA (ortho-phthalaldehyde)-containing compound disinfectant as well as preparation method and application thereof |
| CN105379712A (en) * | 2015-12-15 | 2016-03-09 | 山东消博士消毒科技股份有限公司 | Phthalic dicarboxaldehyde disinfectant for endoscope cleaning and preparation technology thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020096890A1 (en) | 2018-11-05 | 2020-05-14 | Medivators Inc. | Composition for cleaning and assessing cleanliness in real-time |
| EP3852943A4 (en) * | 2018-11-05 | 2022-06-08 | Medivators Inc. | Composition for cleaning and assessing cleanliness in real-time |
| CN111436430A (en) * | 2020-05-20 | 2020-07-24 | 佳木斯大学 | Digestive endoscope disinfectant and preparation method thereof |
| CN112931505A (en) * | 2021-01-22 | 2021-06-11 | 海韵一剑大卫生科技有限公司 | Phthalic dicarboxaldehyde disinfectant, preparation method and application thereof |
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| CN108552173B (en) | 2021-12-03 |
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