CN111436430A - Digestive endoscope disinfectant and preparation method thereof - Google Patents
Digestive endoscope disinfectant and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
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Abstract
The invention relates to a digestive endoscope disinfectant and a preparation method thereof, wherein phthalic dicarboxaldehyde, isopropanol, trichloro-hydroxy diphenyl ether and magnolol are compounded, and sterilization and disinfection components with different mechanisms directly or indirectly act on biological protein of pathogenic microorganisms to enhance the penetration effect on the pathogenic microorganisms such as fungi, bacteria, spores and the like, so that the killing effect of the disinfectant on the microorganisms is enhanced, and the high-level disinfection of precision medical instruments such as a digestive endoscope and the like is realized. Meanwhile, the disinfectant disclosed by the invention also has the advantages of good stability, obvious shortening of soaking time, small corrosivity to medical instruments such as an endoscope and the like.
Description
Technical Field
The invention relates to a digestive endoscope disinfectant and a preparation method thereof, belonging to the field of disinfectant.
Background
Digestive endoscopy is a precision examination instrument used repeatedly and is an important diagnosis and treatment means in the field of digestion. However, since the digestive endoscopy is expensive and needs to enter the human body for examination and treatment, the disinfection problem has become one of the important problems for ensuring the health of patients and preventing iatrogenic infections.
At present, the disinfection of the digestive endoscopy mainly comprises two types of chemical liquid medicine and gas, wherein the chemical liquid medicine soaking is a more common disinfection method. Chemical disinfectants are widely available, such as benzalkonium bromide (benzalkonium bromide), chlorine-containing disinfectants, glutaraldehyde, peracetic acid, and the like. They have the functions of inactivating various bacteria and a few spore bacteria, can also inactivate fungi and viruses, and have no corrosiveness. Benzalkonium bromide has a killing effect on viruses, but the disinfection time is long, otherwise, the disinfection effect is poor, so that the benzalkonium bromide is not advocated for use at present; the chlorine-containing disinfectant can damage the endoscope hose after long-term use and is less used clinically. Glutaraldehyde is a disinfectant commonly used at present in China, but the glutaraldehyde is large in smell, harmful to both human bodies and the environment, long in soaking time, and various problems that the glutaraldehyde damages health of doctors and patients, drug-resistant bacteria occur in clinical application and the like. The peroxyacetic acid has obviously improved disinfection rate and effect on the digestive endoscopy, but still has pungent smell. The o-phthalaldehyde serving as a high-efficiency disinfection sterilizing agent has the advantages of high efficiency, high speed, low toxicity, low irritation and the like, and is increasingly concerned and widely used. However, currently, the prior art has a few ortho-phthalaldehyde products to choose from.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the digestive endoscope disinfectant which has the characteristics of high-level disinfection, short soaking time, small irritation and the like, and has a remarkable killing effect on fungi, bacteria, spores and the like.
In order to realize the invention, the technical scheme is that the digestive endoscope disinfectant comprises, by mass, 0.5-5% of o-phthalaldehyde, 5-10% of isopropanol, 0.5-2% of trichloro-hydroxy-diphenyl ether, 1.5-5% of magnolol, 1-10% of a surfactant, 0.5-10% of a cosolvent, 0.2-5% of a corrosion inhibitor, 0.2-6% of a stabilizer, a proper amount of a pH regulator and the balance of water.
In a preferred embodiment, the surfactant is selected from one or more of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene, fatty acid alkanolamide, polyoxyethylene polyoxypropylene propylene glycol ether, cetyl trimethylammonium bromide, dioctadecyl dimethylammonium bromide, sodium laureth sulfate, sodium myristyl polyether sulfate, or cocamidopropyl betaine.
In a preferred embodiment, the co-solvent is selected from one or more of ethanol, glycerol, propylene glycol and polyethylene glycol.
In a preferred embodiment, the corrosion inhibitor is selected from one or more of silicates, molybdates, phytic acid, pentaerythritol, sodium hexametaphosphate and sodium polyphosphate.
In a preferred embodiment, the stabilizer may include a chelating agent and/or an antioxidant; the chelating agent is one or more selected from ethylenediamine tetraacetic acid and sodium salt thereof, sodium tripolyphosphate, sodium polyphosphate, sodium hexametaphosphate, sodium pyrophosphate, ethylenediamine tetraacetic acid and sodium thereof; the antioxidant is selected from one or more of ascorbic acid, ascorbyl palmitate, sodium sulfite, sodium thiosulfate, ammonium metabisulfite and cysteine.
In a preferred embodiment, the pH adjusting agent is one or more of strong inorganic bases, carbonates, bicarbonates, boric acid, borax, potassium dihydrogen phosphate and disodium hydrogen phosphate.
In a preferred embodiment, the pH value of the disinfection solution for digestive endoscopy is 7.5-8.5.
The invention also aims to provide a preparation method of the digestive endoscope disinfectant, which comprises the following steps:
mixing o-phthalaldehyde, isopropanol, a corrosion inhibitor and a stabilizer with part of water, heating while stirring to obtain a mixed solution 1;
mixing trichloro-hydroxy-diphenyl ether, magnolol, surfactant, cosolvent and residual water, and stirring while heating to obtain a mixed solution 2;
and mixing the mixed solution 1 and the mixed solution 2, uniformly stirring, and adding a pH regulator until the pH value is 7.5-8.5 to obtain the digestive endoscope disinfectant.
Advantageous effects
The invention applies magnolol as an effective component to the disinfection field of the digestive endoscopy for the first time. The invention compounds o-phthalaldehyde, isopropanol, trichloro-hydroxy diphenyl ether and magnolol, adopts different mechanisms of sterilization and disinfection components to directly or indirectly act on biological protein of pathogenic microorganisms, enhances the penetration effect on the pathogenic microorganisms such as fungi, bacteria, spores and the like, further enhances the killing effect of the disinfectant on the microorganisms, and realizes high-level disinfection of precision medical instruments such as digestive endoscopy and the like. Meanwhile, the disinfectant disclosed by the invention also has the advantages of good stability, obvious shortening of soaking time, small corrosivity to medical instruments such as an endoscope and the like.
The disinfectant also comprises the components of a surfactant, a cosolvent, a corrosion inhibitor, a stabilizer and the like. The contact area of the effective components to the surfaces of pathogenic microorganisms is increased by utilizing the wetting, penetration promoting and other effects of the surfactant, and the killing effect of the effective components to the pathogenic microorganisms is promoted. The cosolvent accelerates the dissolution and mutual fusion speed of the components such as o-phthalaldehyde, trichloro-hydroxy-diphenyl ether, magnolol and the like, and avoids the unstable effect caused by uneven mixing of the effective components and the loss of the effective components caused by long-time stirring and heating. The corrosion of the digestive endoscope containing the phthalaldehyde and other components is reduced by adding the corrosion inhibitor. The stabilizer enhances the oxidation resistance of the digestive juice and ensures the stable quality of the product.
Detailed Description
The invention may be further understood by reference to the following examples, which illustrate some methods of making or using. However, it is to be understood that these examples do not limit the present invention. Variations of the invention, now known or further developed, are considered to fall within the scope of the invention as described herein and claimed below.
Example 1
A digestive endoscope disinfectant comprises, by mass, 2.5% of o-phthalaldehyde, 6% of isopropanol, 1% of trichloro-hydroxy-diphenyl ether, 2.5% of magnolol, 5% of polyoxyethylene polyoxypropylene propylene glycol ether, 3% of propylene glycol, 1% of sodium silicate, 1.5% of sodium hexametaphosphate, 1.5% of ascorbyl palmitate, a proper amount of a pH regulator and the balance of water.
The preparation method of the digestive juice comprises the following steps:
mixing phthalaldehyde, isopropanol, sodium silicate, sodium hexametaphosphate and ascorbyl palmitate with part of water, and stirring while heating to obtain a mixed solution 1;
mixing trichlorohydroxydiphenyl ether, magnolol, polyoxyethylene polyoxypropylene propylene glycol ether, propylene glycol and residual water, heating while stirring to obtain a mixed solution 2;
and mixing the mixed solution 1 and the mixed solution 2, uniformly stirring, and adding a pH regulator until the pH value is 8.5 to obtain the digestive endoscope disinfectant.
Example 2
A digestive endoscope disinfectant comprises, by mass, 2% of o-phthalaldehyde, 5% of isopropanol, 1.5% of trichloro-hydroxy-diphenyl ether, 3% of magnolol, 6% of sodium laureth sulfate, 2.5% of polyethylene glycol, 2% of sodium molybdate, 1.5% of sodium ethylene diamine tetracetate, 1.5% of cysteine, a proper amount of a pH regulator and the balance of water.
The preparation method of the digestive juice comprises the following steps:
mixing phthalaldehyde, isopropanol, sodium molybdate, sodium ethylene diamine tetracetate and cysteine with part of water, and stirring while heating to obtain a mixed solution 1;
mixing trichloro-hydroxy-diphenyl ether, magnolol, sodium laureth sulfate, polyethylene glycol and residual water, and stirring while heating to obtain a mixed solution 2;
and mixing the mixed solution 1 and the mixed solution 2, uniformly stirring, and adding a pH regulator until the pH value is 8.5 to obtain the digestive endoscope disinfectant.
Example 3
A digestive endoscope disinfectant comprises, by mass, 1.5% of o-phthalaldehyde, 7% of isopropanol, 1% of trichloro-hydroxydiphenyl ether, 2% of magnolol, 8% of cocamidopropyl betaine, 5% of glycerol, 2.5% of sodium polyphosphate, 3% of ascorbyl palmitate, a proper amount of a pH regulator and the balance of water.
The preparation method of the digestive juice comprises the following steps:
mixing o-phthalaldehyde, isopropanol, sodium polyphosphate and ascorbyl palmitate with part of water, and stirring while heating to obtain a mixed solution 1;
mixing trichlorohydroxydiphenyl ether, magnolol, cocamidopropyl betaine, glycerol and the rest water, and stirring while heating to obtain a mixed solution 2;
and mixing the mixed solution 1 and the mixed solution 2, uniformly stirring, and adding a pH regulator until the pH value is 8.5 to obtain the digestive endoscope disinfectant.
Comparative example 1
A disinfection solution for a digestive endoscope comprises, by mass, 1.5% of o-phthalaldehyde, 6% of isopropanol, 1% of trichloro-hydroxy-diphenyl ether, 2.5% of benzalkonium bromide, 5% of polyoxyethylene polyoxypropylene propylene glycol ether, 3% of propylene glycol, 1% of sodium silicate, 1.5% of sodium hexametaphosphate, 1.5% of ascorbyl palmitate, a proper amount of a pH regulator and the balance of water.
The preparation method of the digestive juice comprises the following steps:
mixing phthalaldehyde, isopropanol, sodium silicate, sodium hexametaphosphate and ascorbyl palmitate with part of water, and stirring while heating to obtain a mixed solution 1;
mixing trichloro hydroxy diphenyl ether, benzalkonium bromide, polyoxyethylene polyoxypropylene propylene glycol ether, propylene glycol and the rest water, heating while stirring to obtain a mixed solution 2;
and mixing the mixed solution 1 and the mixed solution 2, uniformly stirring, and adding a pH regulator until the pH value is 8.5 to obtain the digestive endoscope disinfectant.
Comparative example 2:
a digestive endoscope disinfectant comprises, by mass, 1.5% of o-phthalaldehyde, 6% of ethanol, 1% of trichloro-hydroxy-diphenyl ether, 2.5% of magnolol, 5% of polyoxyethylene polyoxypropylene propylene glycol ether, 3% of propylene glycol, 1% of sodium silicate, 1.5% of sodium hexametaphosphate, 1.5% of ascorbyl palmitate, a proper amount of a pH regulator and the balance of water.
The preparation method of the digestive juice comprises the following steps:
mixing phthalaldehyde, ethanol, sodium silicate, sodium hexametaphosphate and ascorbyl palmitate with part of water, and stirring while heating to obtain a mixed solution 1;
mixing trichlorohydroxydiphenyl ether, magnolol, polyoxyethylene polyoxypropylene propylene glycol ether, propylene glycol and residual water, heating while stirring to obtain a mixed solution 2;
and mixing the mixed solution 1 and the mixed solution 2, uniformly stirring, and adding a pH regulator until the pH value is 8.5 to obtain the digestive endoscope disinfectant.
Comparative example 3:
a digestive endoscope disinfectant comprises, by mass, 1.5% of glutaraldehyde, 6% of isopropanol, 1% of trichlorohydroxydiphenyl ether, 2.5% of magnolol, 5% of polyoxyethylene polyoxypropylene propylene glycol ether, 3% of propylene glycol, 1% of sodium silicate, 1.5% of sodium hexametaphosphate, 1.5% of ascorbyl palmitate, a proper amount of a pH regulator and the balance of water.
The preparation method of the digestive juice comprises the following steps:
mixing glutaraldehyde, isopropanol, sodium silicate, sodium hexametaphosphate and ascorbyl palmitate with part of water, heating while stirring to obtain a mixed solution 1;
mixing trichlorohydroxydiphenyl ether, magnolol, polyoxyethylene polyoxypropylene propylene glycol ether, propylene glycol and residual water, heating while stirring to obtain a mixed solution 2;
and mixing the mixed solution 1 and the mixed solution 2, uniformly stirring, and adding a pH regulator until the pH value is 8.5 to obtain the digestive endoscope disinfectant.
Test example 1: the sterilizing effect and the endoscope sterilizing simulation field effect of the disinfectant are inspected.
1. Material
The test indicator bacteria are staphylococcus aureus (ATCC 6538), bacillus subtilis var niger (ATCC9372), escherichia coli (8099) and candida albicans (ATCC 10231), and are provided by China general microbiological culture collection.
Preparing a bacterial suspension and a bacterial infection carrier: taking each test strain, performing enrichment culture, taking a single typical colony to inoculate a nutrient agar culture medium inclined plane, washing down the lawn on the inclined plane after culture, and preparing bacterial suspension with required concentration by using diluent for later use; culturing black variant spore suspension of Bacillus subtilis according to 2002 edition "Disinfection technical Specification", placing sterilized polytetrafluoroethylene tube carrier, contaminating bacterial spore in the tube, requiring the recovered bacterial number to reach relevant regulation requirement, and air drying for use.
2. Method of producing a composite material
2.1 quantitative sterilization test of suspension: the disinfectant of the present invention (examples 1 to 3) and the disinfectant of comparative examples 1 to 3 were placed in a water bath (20 ℃) together with the bacterial suspension and kept at a constant temperature for 5 minutes. 4ml of the disinfectant of examples 1 to 3 of the present invention and the disinfectant of comparative examples 1 to 3 were respectively sucked by a sterile pipette and injected into six identical sterile test tubes, 0.5ml of the bacterial suspension and 0.5ml of 3% bovine serum albumin were respectively sucked and added into the two sterile test tubes, and the two sterile test tubes were mixed to form a uniform bacterial-drug mixture. The bacteria and medicine mixed liquor is interacted for a fixed time, 0.5ml of the bacteria and medicine mixed liquor is absorbed and added into 4.5ml of neutralizing agent, and the mixture is evenly mixed. Neutralizing for 10min, counting viable bacteria, and calculating killing logarithm value. The test was performed 3 times.
2.2 endoscope disinfection simulation field test: according to the requirements of technical specification (trial) for testing the disinfection effect of endoscope cleaning and disinfecting machines, the disinfection solutions of examples 1-3 and comparative examples 1-3 are filled in a disinfection tank of the endoscope cleaning and disinfecting machine, the pipelines of the simulated endoscope body are cut at the positions of 50nm, 500nm and 950nm, the carriers of the infectious microbes are respectively connected at the positions of 50nm, 500nm and 950nm, and the simulated endoscope body is filled in the endoscope cleaning and disinfecting machine. Treating according to disinfection program (initial washing for 2min, enzyme washing for 2min, washing for 1min, soaking for 5min, and final washing for 2min), and taking off the carrier after the program is finished to perform viable bacteria culture counting. The test was performed 3 times.
3. Test results
3.1 quantitative bactericidal Effect of suspension
Test results show that the disinfectant disclosed by the invention acts on escherichia coli, staphylococcus aureus and candida albicans in suspension for 1min and 3min respectively, and killing log values are shown in the following table 1. The bacillus subtilis black variety spores were affected for 30min and 60min, and the average killing log values are shown in table 2 below. The disinfectant of the embodiment 1 of the invention is obviously superior to that of the comparative example 1 in escherichia coli, staphylococcus aureus and candida albicans. For the action of the black variant spores of the bacillus subtilis, the disinfectant of the embodiment 1 of the invention can achieve the effect of average killing logarithm value >5 only by acting for 30min, and the acting time is obviously shortened compared with that of the comparative example 1.
TABLE 1 comparison of the killing effect of the disinfectant of the present invention on pathogenic bacteria
TABLE 2 comparison of the killing effect of the disinfectant of the present invention on the black variety spores of Bacillus subtilis
3.2 simulation of on-site effects of endoscope sterilization
Test results show that the disinfectant of the invention is filled in an endoscope cleaning and disinfecting machine to simulate on-site disinfection, and after treatment according to disinfection procedures (initial washing for 2min, enzyme washing for 2min, washing for 1min, soaking and disinfecting for 5min and final washing for 2min), the effect of eliminating artificially polluted bacillus subtilis black variant spores on a carrier is obviously superior to that of comparative example 1.
TABLE 3 simulation of site test results for disinfection of digestive endoscopy
Test example 2: the stability and the metal corrosiveness of the disinfectant of the invention are examined
1. Stability survey
The hermetically packaged disinfectant of example 1 of the present invention was stored in a 37 ℃ constant temperature and humidity cabinet for 90 days. Sampling before and after placing, measuring the content of the o-phthalaldehyde, and calculating the reduction rate. The calculated ortho-phthalaldehyde content decreased by about 1%.
2. Corrosion test of metals
Preparing stainless steel, aluminum and carbon steel into round pieces with diameter (20 + -1) mm, thickness of 1.0mm and middle hole with diameter of 15mm, grinding surface oxide layer with sand paper, soaking in detergent for 10min, and cleaning; degreasing again by using absolute ethyl alcohol. Dried at 50 ℃ for 1h, weighed and soaked in the disinfectant (100 ml/tablet) of the invention in the embodiment 1 for 72h, and the disinfectant is replaced regularly for 1 time every day. The control group was continuously soaked in distilled water. And (3) taking out the metal sheet after soaking, repeatedly cleaning the metal sheet by using distilled water and a soft brush, sucking the metal sheet by using filter paper, drying the metal sheet at 50 ℃ for 1 hour, weighing the metal sheet, and calculating the corrosion rate. Through detection, the corrosion rate of the disinfectant in the embodiment 1 of the invention to stainless steel is 0.0065mm/a, the corrosion rate to aluminum is 0.0077mm/a, and the corrosion rate to carbon steel is 0.0051mm/a, which are all in the level of no corrosion basically.
Based on the test results, the disinfection effect of the disinfection solution on bacteria and the like is obviously enhanced after magnolol is prepared, the killing time on spores is obviously shortened, the stability is kept, no corrosion is caused to metals, and the disinfection effect is obviously better than that of the prior art.
This summary merely illustrates some embodiments which are claimed, wherein one or more of the features recited in the claims can be combined with any one or more of the embodiments, and such combined embodiments are also within the scope of the present disclosure as if they were specifically recited in the disclosure.
Claims (8)
1. The digestive endoscope disinfectant is characterized by comprising, by mass, 0.5-5% of phthalaldehyde, 5-10% of isopropanol, 0.5-2% of trichloro hydroxy diphenyl ether, 1.5-5% of magnolol, 1-10% of a surfactant, 0.5-10% of a cosolvent, 0.2-5% of a corrosion inhibitor, 0.2-6% of a stabilizer, a proper amount of a pH regulator and the balance of water.
2. The disinfectant solution of claim 1, wherein the surfactant is selected from one or more of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene, fatty acid alkanolamide, polyoxyethylene polyoxypropylene propylene glycol ether, cetyl trimethylammonium bromide, dioctadecyl dimethylammonium bromide, sodium laureth sulfate, sodium myristyl ether sulfate, and cocamidopropyl betaine.
3. The disinfecting solution of claim 1, wherein the cosolvent is selected from one or more of ethanol, glycerol, propylene glycol, and polyethylene glycol.
4. The disinfecting solution of claim 1, wherein the corrosion inhibitor is selected from one or more of silicates, molybdates, phytic acid, pentaerythritol, sodium hexametaphosphate, and sodium polyphosphate.
5. The disinfecting solution of claim 1, wherein the stabilizer comprises a chelating agent and/or an antioxidant; the chelating agent is one or more selected from ethylenediamine tetraacetic acid and sodium salt thereof, sodium tripolyphosphate, sodium polyphosphate, sodium hexametaphosphate, sodium pyrophosphate, ethylenediamine tetraacetic acid and sodium thereof; the antioxidant is selected from one or more of ascorbic acid, ascorbyl palmitate, sodium sulfite, sodium thiosulfate, ammonium metabisulfite and cysteine.
6. The disinfecting solution of claim 1, wherein the pH regulator is one or more of strong inorganic bases, carbonates, bicarbonates, boric acid, borax, potassium dihydrogen phosphate and disodium hydrogen phosphate.
7. The disinfectant liquid according to claim 1, wherein the pH value of the disinfectant liquid for digestive endoscopy is 7.5-8.5.
8. The method of preparing the disinfecting solution of claim 1, comprising the steps of:
mixing o-phthalaldehyde, isopropanol, a corrosion inhibitor and a stabilizer with part of water, heating while stirring to obtain a mixed solution 1;
mixing trichloro-hydroxy-diphenyl ether, magnolol, surfactant, cosolvent and residual water, and stirring while heating to obtain a mixed solution 2;
and mixing the mixed solution 1 and the mixed solution 2, uniformly stirring, and adding a pH regulator until the pH value is 7.5-8.5 to obtain the digestive endoscope disinfectant.
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| CN112244020A (en) * | 2020-09-16 | 2021-01-22 | 山东利尔康医疗科技股份有限公司 | Low-foam low-odor phthalic dicarboxaldehyde formula and preparation method thereof |
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