CN104621104A - Disinfectant with low corrosiveness - Google Patents
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Abstract
The invention provides a disinfectant with low corrosiveness. The disinfectant comprises the following components by weight percent: 0.2-2.0% of ortho-phthalaldehyde, 1-10% of a synergist, 10-50% of a cosolvent, 0.5-5% of a buffering agent, 1-10% of a penetrant, 0.2-2% of a corrosion inhibitor, 0.1-5% of a chelating agent, 0.1-3% of a stabilizing agent and 45-80% of purified water. After the disinfectant is used, intestinal tract pathogenic bacteria, pyogenic coccus, hepatitis virus, H7N9 avian influenza virus, black variant spores of bacillus subtilis and other pathogenic microorganisms can be killed within a short time. Furthermore, the disinfectant adopts a slow release technique, thus having extremely low corrosiveness on metal and being very suitable for disinfecting medical equipment.
Description
Technical field
The invention belongs to disinfectant field, be specifically related to a kind of low-corrosiveness disinfectant.
Background technology
Along with the raising of medical technology and carrying out of hygiene industry, the kind of clinical surgical instrument also gets more and more, operating theater instruments belongs to high risk article,, in the process such as utilization, cleaning, sterilization, very easily there is rust staining, not easily eliminate in the body fluid of frequent contact patient and tissue, so both affect the service life of operating theater instruments, be difficult to again arrive effective sterilization effect, the utilization quality of operating theater instruments cannot be guaranteed, very easily form hospital-acquired infection.Very strong corrosion can be caused to medicine equipment when using severe corrosive disinfectant to carry out disinfection, its formed harm mainly contain following some: 1, affect wound healing or infection, the apparatus got rusty is as contact wound, wound healing rate can be caused reduce, the course of disease extends, and can form the tetanus infection of deep wound time serious.2, add patient's suffering, the appliance function of getting rusty is poor, as blade, scissors rust, with the addition of the friction to skin, increases patient's suffering.
The disinfectant being applicable to medicine equipment at present both at home and abroad mainly contains aldehyde disinfectant, peroxide sterilants and chlorine-containing disinfectant.From service condition, glutaraldehyde has wide spectrum, efficient, excitant is little, corrosivity is weak, the advantage of soluble in water, stable in properties, becomes topmost product in medical apparatus sterilizing liquid.Regulation in " endoscope cleaning disinfection technology working specification " (version in 2004), when needing the scope of sterilization to adopt 2% alkaline glutaric dialdehyde to sterilize, soak time is: gastroscope, intestines mirror, ERCP soak and be no less than 10 minutes; Bronchoscope soaks and is no less than 20 minutes; Scope after the special infected patient such as tubercle bacillus, other mycobacteriums uses soaks and is no less than 45 minutes.When needing the scope of sterilizing to adopt 2% alkaline glutaric dialdehyde sterilizing, 10 hours must be soaked.Adopt glutaraldehyde long to the scope not only disinfecting time that carries out disinfection, glutaraldehyde has certain toxicity simultaneously, irritant to skin and mucosa, the healing of wound can be delayed, especially corneal has damage, affects one's power of vision, and also has certain sensitization, glutaraldehyde also need in use to add there is carcinogenicity natrium nitrosum as corrosion inhibiter, to human body, there is potential carcinogenic risk.Peracetic acid is most popular one in peroxide disinfectant, and be a kind of wide spectrum, efficient, quick-acting bactericidal agents, peracetic acid soln all has stronger bactericidal action to bacterium, fungi, gemma and virus.But liquid peroxy acetic acid has strong acid, the feature of severe corrosive, peracetic acid soln is unstable simultaneously, easily decomposes at normal temperatures, even can set off an explosion during high temperature, all brings great inconvenience to its transport and use.Chlorine-containing disinfectant is owing to having stronger excitant, and its catabolite also can cause certain injury to environment simultaneously, is also subject to certain restrictions in actual use with this.
Chinese patent application CN102870814A discloses a kind of sterilization of medical instrument disinfectant, adopts the sterilization of medical instrument disinfectant of the compositions such as chlorination alkyl benzyl ammonium chloride, sodium perborate and glutaraldehyde.It mainly plays sterilization composition is glutaraldehyde, adding chlorination alkyl benzyl ammonium chloride is synergist, although can improve when traditional glutaraldehyde disinfectant uses and need activation, use loaded down with trivial details shortcoming, this disinfectant does not solve the shortcoming that glutaraldehyde disinfectant toxicity is large and corrosivity is strong.Chinese patent CN101828551A discloses a kind of stable peroxyacetic acid disinfectant, improves peroxyacetic acid disinfectant stability to a certain extent, but with the addition of glacial acetic acid and the concentrated sulfuric acid in disinfectant, makes disinfectant have severe corrosive.Chinese patent application CN1582661A discloses a kind of solid chlorine dioxide disinfectant, because adding oxalic acid and citric acid, makes this solid chlorine dioxide disinfectant have stronger corrosivity equally.
In order to adapt to the high frequency of utilization of modern hospital to medicine equipment, the effect of sterilization, sterilizing can be realized rapidly, reduce the labour intensity of health care worker, therefore so a kind of demand is existed to the sterilization of medicine equipment: the bacterium on medicine equipment, fungi, virus and other microorganisms can be killed within the extremely short time, also greatly will reduce the damage to medicine equipment simultaneously.
Summary of the invention
The object of this invention is to provide a kind of bacterium can killed within the extremely short time on medicine equipment, fungi, virus and other microorganisms, simultaneously little to the damage of medicine equipment disinfectant.
Low corrosion disinfectant of the present invention is made up of o-phthalaldehyde(OPA), synergist, cosolvent, buffer, bleeding agent, chelating agent, stabilizing agent and purified water, by mass percentage o-phthalaldehyde(OPA) 0.2% ~ 5.0%, synergist 1% ~ 10%, cosolvent 10% ~ 50%, buffer 0.1% ~ 5%, bleeding agent 1% ~ 10%, corrosion inhibiter 0.1% ~ 2%, chelating agent 0.1% ~ 5%, stabilizing agent 0. 1% ~ 3% and purified water 45% ~ 80%.
Described disinfectant, the composition playing main disinfective action is o-phthalaldehyde(OPA).
Described synergist is selected from least one in chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene guanide, poly hexamethylene biguanide, hexa, Triclosan, o-phenyl phenol, PCMX, Efficacious Disinfeitant, benzalkonium chloride, benzalkonium bromide, BCDMH, two octyldimethyl ammonium chloride, double-track suspended self-propelled conveyor, at least one preferably in chlorhexidine acetate, poly hexamethylene biguanide, benzalkonium bromide and double-track suspended self-propelled conveyor.
Described cosolvent is selected from least one in ethanol, propane diols, isopropyl alcohol.
Described buffer is selected from least one in tartaric acid, malic acid, citric acid, benzoic acid, salicylic acid, phthalic acid, phosphate, carbonate, borate, at least one preferably in phthalic acid, phosphate, carbonate, borate.
Described bleeding agent is selected from least one in fatty alcohol-polyoxyethylene ether, alkylphenol-polyethenoxy, fatty acid alkanol amides, polyoxyethylene polyoxypropylene propylene glycol, alkyl-glucoside, sucrose fatty ester, dimethyl sulfoxide (DMSO), at least one preferably in fatty alcohol-polyoxyethylene ether, alkylphenol-polyethenoxy and dimethyl sulfoxide (DMSO).
Described chelating agent is selected from sodium phosphate trimer, sodium polyphosphate, calgon, sodium pyrophosphate, edta and its sodium salt, polyacrylic acid, maleic acid, diethylene-triamine pentaacetic acid (DTPA), N-ethoxy ethamine triacetic acid (HEDTA), ethylene glycol-bis--(beta-amino ether)-N, N-tetraacethyl (EGTA), ATMP (ATMP), 1-hydroxyl ethylidene-1, 1-di 2 ethylhexyl phosphonic acid (HEDP), ethylene diamine tetra methylene phosphonic acid (EDTMP), diethylene triamine pentamethylene phosphonic (DTPMP), at least one in ATMP (ATP), preferably from calgon, edta and its sodium salt, at least one in polyacrylic acid and ethylene diamine tetra methylene phosphonic acid (EDTMP).
Described corrosion inhibiter is selected from least one in chromate, molybdate, tungstates, vanadate, orthophosphates, borate, phosphonic acids, phosphonate, phosphine carboxylic acid, mercaptobenzothiazoler, Sodium Benzoate, methenamine, triethanolamine, BTA, nitrous acid bicyclohexylamine, thiocarbamide, di-o-tolyl-thiourea, dibutyl thiourea, alkylpyridinium chlorides.At least one preferably in phosphonic acids, phosphonate, Sodium Benzoate, BTA.
Described stabilizing agent is selected from least one in sodium sulphite, sodium thiosulfate, pyrosulfurous acid ammonia, cysteine, ascorbic acid.At least one preferably in sodium thiosulfate, ascorbic acid.
In the present invention, main disinfection composition is o-phthalaldehyde(OPA), o-phthalaldehyde(OPA) mainly relies on the alkylating of its free aldehyde radical, directly or indirectly act on the different groups of bioprotein molecule, it is made to lose biologic activity, thus cause microbial death, have the advantages that sterilizing time is short, working concentration is low, toxicity is little, metal protection is little, and material compatibility is good, pathogenic microorganisms can be killed rapidly.Synergist mainly plays the effect of Synergistic biocidal, strengthens disinfectant to the penetration of pathogenic microorganisms, especially to the penetration of bacterial spore, strengthens disinfectant to the killing effect of bacterial spore.Cosolvent mainly plays the effect strengthening o-phthalaldehyde(OPA) solvability, can be dissolved in the water better, fat-soluble very strong due to o-phthalaldehyde(OPA), and cosolvent can reduce the surface tension of water, increases the solvability of o-phthalaldehyde(OPA) in water.Buffer mainly plays the effect regulating pH, strengthens o-phthalaldehyde(OPA) penetrating bacterial spore wall, changes the permeability of bacterial spore wall, makes o-phthalaldehyde(OPA) can penetrate into gemma inwall, alkylation gemma, causes gemma to lose the function of germinateing.Bleeding agent mainly plays the effect reducing thimerosal surface energy, strengthens the penetration of disinfectant cell membrane, strengthens the Disinfection Effect of disinfectant.Chelating agent mainly plays the effect reducing concentration of metal ions, reduces metal ion to the impact of disinfectant, plays the effect strengthening Disinfection Effect.Corrosion inhibiter mainly plays and reduces disinfectant to corrosion of metal effect, lowers o-phthalaldehyde(OPA) further to corrosion of metal, strengthens the service life of medicine equipment, reduce the comprehensive use cost of medicine equipment.Stabilizing agent mainly plays and reduces environmental factor to the impact of o-phthalaldehyde(OPA) stability, makes o-phthalaldehyde(OPA) not oxidized, strengthens its stability.
Low-corrosiveness disinfectant of the present invention, be specially adapted to medicine equipment as operating theater instruments, endoscope, the sterilization of catheter etc., compared with existing medical apparatus sterilizing agent, sterilizing ability of the present invention is strong, sterilizing time is short, the all microorganisms comprising Escherichia coli, staphylococcus aureus, Candida albicans can be killed in 5 minutes, the logarithm value > 5.0 of Bacillus subtilis endophyticus gemma can be killed in 60min, greatly save disinfection time of medical appliances.Disinfectant acute oral toxicity mouse LD of the present invention
50> 5000mg/kgbw, according to acute toxicity grading criteria, the nontoxic level in true border.The aqueous solution of disinfectant of the present invention to stainless steel, carbon steel, copper and aluminium all no corrosions, to medicine equipment not damaged.
Embodiment
Below by embodiment, disinfectant of the present invention is described, but the present invention is not limited to this.
Embodiment 1: o-phthalaldehyde(OPA) 0.5%, two octyldimethyl ammonium chloride 1.0%, propane diols 35%, sodium carbonate 3%, dimethyl sulfoxide (DMSO) 6%, BTA 1.5%, calgon 1%, sodium thiosulfate 0.5% and purified water 51.5%.
Embodiment 2: o-phthalaldehyde(OPA) 1.0%, two octyldimethyl ammonium chloride 3.0%, isopropyl alcohol 30%, borate 2%, alkylphenol polyoxyethylene 5%, phosphonic acids 1.0%, disodium EDTA 2.0%, ascorbic acid 1.0% and purified water 55%.
Embodiment 3: o-phthalaldehyde(OPA) 1.5%, benzalkonium chloride 3.0%, isopropyl alcohol 30%, borate 2%, alkylphenol polyoxyethylene 8%, Alendronate 1.5%, polyacrylic acid 3%, ascorbic acid 3% and purified water 48%.
Embodiment 4: o-phthalaldehyde(OPA) 2.0%, benzalkonium chloride 2.0%, ethanol 25%, sodium dihydrogen phosphate 3%, fatty alcohol-polyoxyethylene ether 4%, Sodium Benzoate 0.5%, ethylenediamine tetraacetic methene phosphine 4.0%, sodium thiosulfate 0.5% and purified water 59%.
Embodiment 5: o-phthalaldehyde(OPA) 3.5%, hexa 2.0%, Triclosan 4.0%, o-phenyl phenol 3.0%, ethanol 10.0%, propane diols 5.0%, malic acid 1.0%, citric acid 1.0%, sodium bicarbonate 2.0%, fatty acid alkanol amides 2.0%, polyoxyethylene polyoxypropylene propylene glycol 3.0%, alkyl-glucoside 4.0%, methenamine 1.0%, triethanolamine 0.5%, BTA 0.4%, N-tetraacethyl (EGTA) 1.5%, ATMP (ATMP) 2.5%, cysteine 1.5%, ascorbic acid 1.3%, with purified water 50.8%.
Embodiment 6: o-phthalaldehyde(OPA) 4.0%, benzalkonium bromide 1.0%, BCDMH 1.0%, two octyldimethyl ammonium chloride 3.0%, ethanol 5.0%, propane diols 5.0%, isopropyl alcohol 15.0%, phthalic acid 1.5%, sodium hydrogen phosphate 1.5%, sucrose fatty ester 1.0%, dimethyl sulfoxide (DMSO) 1.0%, sodium tungstate 0.5%, sodium vanadate 1.0%, calgon 1.0%, sodium pyrophosphate 2.0%, sodium thiosulfate 0.1%, pyrosulfurous acid ammonia 0.2% and purified water 56.2%.
Embodiment 7: o-phthalaldehyde(OPA) 0.3%, benzalkonium bromide 1.0%, BCDMH 2.0%, ethanol 15.0%, isopropyl alcohol 20.0%, malic acid 1.0%, sodium tetraborate 1.0%, fatty alcohol-polyoxyethylene ether 1.5%, alkylphenol-polyethenoxy 2.5%, thiocarbamide 0.2%, di-o-tolyl-thiourea 0.3%, polyacrylic acid 0.1%, maleic acid 0.4%, cysteine 0.5% and purified water 54.2%.
Embodiment 8: o-phthalaldehyde(OPA) 1.0%, two octyldimethyl ammonium chloride 1.0%, double-track suspended self-propelled conveyor 1.0%, ethanol 3.0%, propane diols 17.0%, benzoic acid 0.5%, sodium carbonate 0.5%, fatty acid alkanol amides 0.5%, dimethyl sulfoxide (DMSO) 1.5%, alkylpyridinium chlorides 0.1%, methenamine 0.1%, sodium polyphosphate 0.1%, calgon 0.1%, pyrosulfurous acid ammonia 0.1%, ascorbic acid 0.1% and purified water 73.4%.
germicidal test
Test basis: Ministry of Public Health's version " disinfection technology standard " in 2002.
Experimental strain: Escherichia coli (8099), staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231) and Bacillus subtilis endophyticus gemma (ATCC9372).
Test temperature: 20 DEG C.
Sterilizing time: Escherichia coli (8099), staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231) 5min; Bacillus subtilis endophyticus gemma (ATCC9372) 60min.
Under experimental conditions, in embodiment 1 ~ 8, arbitrary thimerosal is to Escherichia coli (8099), staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231) and Bacillus subtilis endophyticus gemma (ATCC9372), act on 5min and 60min respectively, all can reach desirable Disinfection Effect, experimental result is in table 1.
Table 1 kill oncomelania
2 acute oral toxicity tests
Test basis: Ministry of Public Health's version " disinfection technology standard " in 2002.
Germicidal efficacy: every day observes and records each treated animal poisoning manifestations and dead animal number, and general pathology inspection is carried out to the surviving animals in test when dead animal and off-test.14d off-test.
Experimental result shows, observe 14 days process small mouses in embodiment 1 ~ 8 after arbitrary thimerosal feeding mouse and all do not occur exception, death condition does not appear in mouse, and put to death mouse when 14d and dissect, general pathology checks without exception.Experimental result is in table 2.
Table 2 acute oral toxicity test
Experimental result shows medical apparatus sterilizing agent acute oral toxicity mouse LD of the present invention
50> 10000mg/kgbw, according to acute toxicity grading criteria, the nontoxic level in the true border of medical apparatus sterilizing powder provided by the invention.
metal protection is tested
Test basis: Ministry of Public Health's version " disinfection technology standard " in 2002.
Experiment material: stainless steel GB1220-75, carbon steel GB700-65, copper GB2060-80.
Test temperature: 20 DEG C.
Experimental result shows: the aqueous solution of medical apparatus sterilizing agent provided by the invention is to stainless steel, carbon steel and copper no corrosion.
Claims (8)
1. a low-corrosiveness disinfectant, it is characterized in that: be made up of o-phthalaldehyde(OPA), synergist, cosolvent, buffer, bleeding agent, chelating agent, stabilizing agent and purified water, by mass percentage o-phthalaldehyde(OPA) 0.2% ~ 2.0%, synergist 1% ~ 10%, cosolvent 10% ~ 50%, buffer 0.5% ~ 5%, bleeding agent 1% ~ 10%, corrosion inhibiter 0.2% ~ 2%, chelating agent 0.1% ~ 5%, stabilizing agent 0. 1% ~ 3% and purified water 45% ~ 80%.
2. disinfectant according to claim 1, is characterized in that described synergist is at least one in chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene guanide, poly hexamethylene biguanide, hexa, Triclosan, o-phenyl phenol, PCMX, Efficacious Disinfeitant, benzalkonium chloride, benzalkonium bromide, BCDMH, two octyldimethyl ammonium chloride, double-track suspended self-propelled conveyor.
3. disinfectant according to claim 1, is characterized in that described cosolvent is selected from least one in ethanol, propane diols, isopropyl alcohol.
4. disinfectant according to claim 1, is characterized in that described buffer is selected from least one in tartaric acid, malic acid, citric acid, benzoic acid, salicylic acid, phthalic acid, phosphate, carbonate, borate.
5. disinfectant according to claim 1, is characterized in that described bleeding agent is selected from least one in fatty alcohol-polyoxyethylene ether, alkylphenol-polyethenoxy, fatty acid alkanol amides, polyoxyethylene polyoxypropylene propylene glycol, alkyl-glucoside, sucrose fatty ester, dimethyl sulfoxide (DMSO).
6. disinfectant according to claim 1, it is characterized in that: described chelating agent is selected from sodium phosphate trimer, sodium polyphosphate, calgon, sodium pyrophosphate, edta and its sodium salt, polyacrylic acid, maleic acid, diethylene-triamine pentaacetic acid DTPA, N-ethoxy ethamine triacetic acid HEDTA, ethylene glycol-bis--(beta-amino ether-N, N-tetraacethyl EGTA, ATMP ATMP, 1-hydroxyl ethylidene-1, 1-di 2 ethylhexyl phosphonic acid HEDP, ethylene diamine tetra methylene phosphonic acid EDTMP, diethylene triamine pentamethylene phosphonic DTPMP, at least one in ATMP ATP.
7. disinfectant according to claim 1, is characterized in that: described corrosion inhibiter is selected from least one in chromate, molybdate, tungstates, vanadate, orthophosphates, borate, phosphonic acids, phosphonate, phosphine carboxylic acid, coloured glaze base benzothiazole, Sodium Benzoate, methenamine, triethanolamine, BTA, nitrous acid bicyclohexylamine, thiocarbamide, di-o-tolyl-thiourea, dibutyl thiourea, alkylpyridinium chlorides.
8. disinfectant according to claim 1, it is characterized in that described stabilizing agent be selected from sodium sulphite, sodium thiosulfate, pyrosulfurous acid ammonia, cysteine, ascorbic acid, at least one.
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| CN105016492A (en) * | 2015-07-09 | 2015-11-04 | 潍坊友容实业有限公司 | Corrosion and scale inhibitor and application thereof in saline-alkali soil brackish water desalting plant |
| CN105379712A (en) * | 2015-12-15 | 2016-03-09 | 山东消博士消毒科技股份有限公司 | Phthalic dicarboxaldehyde disinfectant for endoscope cleaning and preparation technology thereof |
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| CN106614579A (en) * | 2016-10-12 | 2017-05-10 | 南京金甙尔生物技术有限公司 | Disinfectant and application thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439261A (en) * | 2003-03-14 | 2003-09-03 | 杨书堂 | Composition of phthalyl diformaldehyde disinfectant |
| CN1613308A (en) * | 2004-09-24 | 2005-05-11 | 北京长江脉医药科技有限责任公司 | Antiseptics and preparation thereof |
| US20060293542A1 (en) * | 2005-06-28 | 2006-12-28 | Karlheinz Giselbrecht | Process for preparing high-purity, halogen-free o-phthaladehyde |
| CN101785460A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
-
2015
- 2015-02-02 CN CN201510050389.5A patent/CN104621104A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439261A (en) * | 2003-03-14 | 2003-09-03 | 杨书堂 | Composition of phthalyl diformaldehyde disinfectant |
| CN1613308A (en) * | 2004-09-24 | 2005-05-11 | 北京长江脉医药科技有限责任公司 | Antiseptics and preparation thereof |
| US20060293542A1 (en) * | 2005-06-28 | 2006-12-28 | Karlheinz Giselbrecht | Process for preparing high-purity, halogen-free o-phthaladehyde |
| CN101785460A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 程胜中等: "复方邻苯二甲醛消毒液杀菌效果的观察", 《中国消毒学杂志》 * |
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