CN104206413B - A kind of thimerosal for haemodialysis control unit cleaning and sterilizing and preparation method thereof - Google Patents
A kind of thimerosal for haemodialysis control unit cleaning and sterilizing and preparation method thereof Download PDFInfo
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- CN104206413B CN104206413B CN201410411138.0A CN201410411138A CN104206413B CN 104206413 B CN104206413 B CN 104206413B CN 201410411138 A CN201410411138 A CN 201410411138A CN 104206413 B CN104206413 B CN 104206413B
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 title claims abstract description 79
- 229940033663 thimerosal Drugs 0.000 title claims abstract description 79
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 66
- 238000004140 cleaning Methods 0.000 title claims abstract description 64
- 238000001631 haemodialysis Methods 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 80
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims abstract description 70
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 claims abstract description 28
- MSFGZHUJTJBYFA-UHFFFAOYSA-M sodium dichloroisocyanurate Chemical compound [Na+].ClN1C(=O)[N-]C(=O)N(Cl)C1=O MSFGZHUJTJBYFA-UHFFFAOYSA-M 0.000 claims abstract description 22
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000001509 sodium citrate Substances 0.000 claims abstract description 18
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 18
- 239000007853 buffer solution Substances 0.000 claims description 28
- 238000003756 stirring Methods 0.000 claims description 19
- 238000013019 agitation Methods 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 7
- 239000012982 microporous membrane Substances 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 7
- 239000000645 desinfectant Substances 0.000 abstract description 13
- 238000005516 engineering process Methods 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 33
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
- 239000000047 product Substances 0.000 description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000001301 oxygen Substances 0.000 description 10
- 229910052760 oxygen Inorganic materials 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 9
- 230000000322 hemodialysis Effects 0.000 description 9
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 238000003860 storage Methods 0.000 description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 235000015165 citric acid Nutrition 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 238000013112 stability test Methods 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000023555 blood coagulation Effects 0.000 description 4
- 239000012459 cleaning agent Substances 0.000 description 4
- 230000007797 corrosion Effects 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
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- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 241000186216 Corynebacterium Species 0.000 description 3
- 241000726221 Gemma Species 0.000 description 3
- 241000191938 Micrococcus luteus Species 0.000 description 3
- 229920002413 Polyhexanide Polymers 0.000 description 3
- 241000191940 Staphylococcus Species 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
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- 238000004519 manufacturing process Methods 0.000 description 3
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- 108091005508 Acid proteases Proteins 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 102100031939 Erythropoietin Human genes 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000565675 Oncomelania Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000001877 deodorizing effect Effects 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 229940124274 edetate disodium Drugs 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- HQWDILUMZXPFNW-UHFFFAOYSA-N 2-cyano-2-nitroacetamide Chemical class NC(=O)C(C#N)[N+]([O-])=O HQWDILUMZXPFNW-UHFFFAOYSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 108090000394 Erythropoietin Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000295146 Gallionellaceae Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
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- 239000003599 detergent Substances 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 229940105423 erythropoietin Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
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- 150000004706 metal oxides Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- -1 metals salt Chemical class 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
- 229960001907 nitrofurazone Drugs 0.000 description 1
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- 150000002926 oxygen Chemical class 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
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- 238000001556 precipitation Methods 0.000 description 1
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- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
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- 210000003491 skin Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a kind of thimerosal for haemodialysis control unit cleaning and sterilizing, contain in components by weight percent this product: Peracetic acid 0.5%-1.0%, hydrogen peroxide 2.0%-5.0%, pyridine-2-formic acid 0.1%-0.5%, sodium citrate 0.01%-0.05%, sodium dichloro cyanurate 0.2%-2.0%, sulfamic acid 0.05%-1.0%, surplus is water.The present invention prepares that disinfectant preparation technology is simple, easy to use, process conditions are easy to realize, and product stability is good.
Description
Technical field
The present invention relates to a kind of thimerosal, be specifically related to a kind of thimerosal for haemodialysis control unit cleaning and sterilizing and preparation method thereof.
Background technology
Haemodialysis control unit cleaning fluid is blood coagulation analyzer routine use and the reagent in safeguarding, cleans the counting pipeline of blood coagulation analyzer, colorimetric pool and gem hole etc. and makes instrument stabilizer, extends device longevity.Cleaning fluid can make the dirts such as blood clot dissolve, and rinses through dilution, thus reaches the object of cleaning blood coagulation analyzer counting pipe-line system.Haemodialysis control unit is a kind of Medical Instruments, in order to use safety, finishes using at every turn and all needs to clean machine and sterilize.Infection is one of Patients Treated with Long-term Hemodialysis common complication, and is the 2nd cause of disease (on average accounting for 25% of death) causing last kidney failure dialysis patient death eventually, is only second to angiocardiopathy (accounting for 50%).Infect to patient, family, hospital and society, cause serious impact, increase misery and the financial burden of patient.In order to reduce the generation that hemodialysis patient infects, improve its quality of life and survival rate, the positive prevention and nursing strengthening infecting is particularly important.Hemodialysis patient causes resistance to decline due to malnutritive, anaemia, and the store period such as dialysis, intubate, puncture very easily infect, and inflammatory conditions can cause erythropoietin(EPO) opposing and EMP, causes vicious circle.Therefore, every management of hemodialysis unit should be strengthened, standard operation flow process, strict implement hand hygiene specification and sterile working, the disinfection and isolation consciousness of strengthening medical personnel, payes attention to each link in Case treatment, ensure that each measure is all implemented completely, get hold of each link quality and close.
SYSMEXCA-500 model blood coagulation analyzer is applied widely at home, and required cleaning fluid demand is large, but cleaning fluid used mostly is import CACLEANI, expensive, complete dependence on import.Disclose a kind of cleaning fluid in US4745071, but this cleaning fluid composition is complicated, cost is high.In current city, in like product, the concentration of some product is higher, must carry out manual dilution, use inconvenience and increase work load during use, and dilution after product stability bad; Some product is binary preparation, needs to prepare when using again, and same uses inconvenience, and there is great limitation what disinfect dialysis machine pipe-line system; The product with same concentrations can't resolve again the stability problem of this series products, easily produces crystalline solid after unlatching, and impact uses, and therefore the use period of validity of product is not long; And although some external imported product solves the stability problem of this series products, expensive.
Peracetic acid and hydrogen peroxide are peroxide (-O-O), and they can manufacture oxygen (elementary oxygen) after contacting with organic matter, and elementary oxygen can be oxidized and kill microorganism and the metabolite decomposing microorganism, and remaining elementary oxygen becomes stable oxygen.The speed that decomposition of peracetic acid produces elementary oxygen is very fast, can play Disinfection Effect at short notice, and hydrogen peroxide can maintain the Disinfection Effect of long period and remove organic matter.The acetic acid that decomposition of peracetic acid produces can dissolve and remove calcium carbonate, and last acetic acid is oxidized to carbonic acid gas and water by elementary oxygen.Peracetic acid or hydrogen peroxide sterilization speed are fast, and nontoxic, noresidue, is suitable for the sterilization of this kind of medicine equipment of haemodialysis control unit, but they to be used alone sterilization cleaning performance undesirable.Particularly Peracetic acid excitant is large, is corrosive; Stability of Hydrogen Peroxide is poor, is easily subject to metal ion catalysis decomposition and discharges oxygen, make its oxidation disinfection Disability, bring much inconvenience to user.
At present, thimerosal about haemodialysis control unit cleaning and sterilizing also has several existing patent, for the problems referred to above, publication number 101720760A(application number 200810157978.3) patent discloses a kind of multifunctional disinfectant for haemodialysis machine, its with Peracetic acid and hydrogen peroxide for primary raw material, add stabilizing agent salicylic acid, EDETATE DISODIUM, oxine mixes, concrete composition percentage by weight is: Peracetic acid 4.0%-6.0%, hydrogen peroxide 18.0%-22.0%, salicylic acid 0.3%-1.5%, EDETATE DISODIUM 0.3%-1.0%, oxine 0.3%-1.0%, surplus is water.Publication number 103766377A(application number 201210416140.8) patent discloses a kind of citric acid decalcification thimerosal being applied in dialysis machine and water treatment and preparation method thereof, this thimerosal comprises polyhexamethylene guanide, citric acid, lactic acid, malic acid, and surplus is deionized water.The component proportion of described thimerosal is polyhexamethylene guanide 0.001%-5.0%, citric acid 10%-50%, lactic acid 20.0%-40%, malic acid 10%-30%, surplus are deionized water.This thimerosal is that primary raw material is formulated by citric acid, polyhexamethylene guanide, lactic acid and malic acid.Publication number 101664043(application number 200910307991.7) patent discloses a kind of for sterilizing, the thimerosal of cleaning water channel of hemodialysis machine and preparation method thereof, be made up of citric acid, acid regulator, acid protease, high purity water and hydrogen peroxide; Wherein acid regulator sterilization, mass concentration in cleaning water channel of hemodialysis machine thimerosal be 2%-5%, the mass concentration of acid protease in sterilization, cleaning water channel of hemodialysis machine thimerosal be 3000-6000SAPU/100ml, the mass concentration of hydrogen peroxide in sterilization, cleaning water channel of hemodialysis machine thimerosal is 8%-10%, the mass concentration of citric acid in sterilization, cleaning water channel of hemodialysis machine thimerosal is 40%-50%.
The prior art comprising above-mentioned patent document also comes with some shortcomings, and first, existing correlation technique is also fewer, and only stability of thimerosal for haemodialysis control unit cleaning and sterilization is also poor.
Summary of the invention
The technical problem to be solved in the present invention is the shortcoming overcoming haemodialysis control unit cleaning and thimerosal poor stability in prior art, an object of the present invention be to provide a kind of formula rationally, stable performance, easy to use, safety, nontoxic stability are preferably for the thimerosal of haemodialysis control unit cleaning and sterilization.Another object is just to provide the preparation method of above-mentioned thimerosal.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of thimerosal for haemodialysis control unit cleaning and sterilizing, in components by weight percent: Peracetic acid 0.5%-1.0%, hydrogen peroxide 2.0%-5.0%, pyridine-2-formic acid 0.1%-0.5%, sodium citrate 0.01%-0.05%, sodium dichloro cyanurate 0.2%-2.0%(is preferred, sodium dichloro cyanurate 0.4%-1.6%; Be more preferably, sodium dichloro cyanurate 1.2%), sulfamic acid 0.05%-1.0%, surplus is water.
A kind of thimerosal for haemodialysis control unit cleaning and sterilizing, preferred scheme is, in components by weight percent: Peracetic acid 0.6%-0.9%, hydrogen peroxide 2.5%-4.5%, pyridine-2-formic acid 0.2%-0.4%, sodium citrate 0.02%-0.04%, sodium dichloro cyanurate 0.5%-1.5%, sulfamic acid 0.25%-0.8%, surplus is water.
For a thimerosal for haemodialysis control unit cleaning and sterilizing, the scheme be more preferably is, in components by weight percent: Peracetic acid 0.8%, hydrogen peroxide 3.0%, pyridine-2-formic acid 0.3%, sodium citrate 0.03%, sodium dichloro cyanurate 1.0%, sulfamic acid 0.5%, surplus is water.
The preparation method of above-mentioned thimerosal, step is as follows:
(1) pyridine-2-formic acid, sodium citrate and sodium dichloro cyanurate are added in Agitation Tank, after 2-6 minute, add water, stir at 40-60 DEG C after 0.5-1 hour and obtain buffer solution, then the temperature of buffer solution is down to-5-0 DEG C;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 0.3-1 hour, after it fully dissolves, add sulfamic acid again, be finally diluted with water to required concentration, obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
The preparation method of above-mentioned thimerosal, preferred scheme is: step (1) adds water (preferably, adding water after 4 minutes) after 3-5 minute.
The preparation method of above-mentioned thimerosal, preferred scheme is: step (1) stirs after 0.6-0.8 hour and obtains buffer solution (preferably, stirring obtained buffer solution after 0.7 hour at 50 DEG C) at 45-55 DEG C.
The preparation method of above-mentioned thimerosal, preferred scheme is: buffer solution temperature is down to-4 to-2 DEG C (preferably, buffer solution temperature being down to-3 DEG C) by step (1).
The preparation method of above-mentioned thimerosal, preferred scheme is: thimerosal (preferably, continue stirring and obtain thimerosal in 0.6 hour) is stirred 0.5-0.8 hour to obtain in step (2) continuation.
The preparation method of above-mentioned thimerosal, preferred scheme is: the aperture of step (3) described miillpore filter is 0.10-0.45 μm (preferably, aperture is 0.22 μm).
Being described below of each raw material:
Peracetic acid: be colourless liquid, has the typical scent of acetic acid.Peracetic acid is strong oxidizer.Medical industry is used as drinking-water, food and prevents the disinfectant of infectious disease.Peracetic acid is strong oxidizer, there is very strong oxidisability, meet organic matter release nascent oxygen and play oxidation, used by as medical treatment or life disinfecting drug with clorox (having another name called 84 thimerosals), bleaching powder etc., for efficient, quick-acting, low toxicity, wide-spectrum bactericide, all there is killing action to bacterial propagule, gemma, virus, mould.Therefore sterilization, sterilization can be carried out with it.In addition, because Peracetic acid has stronger volatility in atmosphere, carry out sterilization, sterilization has good effect, and low price to air, our sterilization when preventing SARS at present, disinfectant are exactly mainly Peracetic acid.
Hydrogen peroxide: be commonly called as hydrogen peroxide, has faint special odor, can be used as disinfectant.Pure hydrogen peroxide is nattier blue oily liquids.Can mix with any ratio with water, ethanol or ether.Hydrogen peroxide is the liquid of colourless irritant smell.Medically the hydrogen peroxide of conventional 3% carries out wound or tympanitis sterilization.When the wound of it and skin, oral cavity and mucous membrane, fester or dirt meet, decompose immediately and generate oxygen.This oxygen atom being not yet combined into oxygen molecule, has very strong oxidability, when contacting with bacterium, can destroy microorganism, kill bacterium.After kill bacteria, remaining material is without any murder by poisoning, water without any spread effect.Secondary pollution can not be formed.Therefore, hydrogen peroxide is the desirable disinfectant of wound disinfection.But it should be noted that and can not carry out wound disinfection with the hydrogen peroxide that concentration is large, in case skin ambustion and affected part.
Pyridine-2-formic acid: be the good organic ligand of a class, coordination can be carried out with various metals, also there is certain bactericidal action, be again can form stable material with peroxide by intermolecular hydrogen bonding effect simultaneously, play the effect of Stabilizing Hydrogen Peroxide and Peracetic acid.Make hydrogen peroxide and Peracetic acid bactericidal action insist on Kubo to hold, thus give play to better cleaning and bactericidal action.
Sodium citrate: outward appearance is that white arrives clear crystal, has the taste of suds, can be used as the auxiliary agent of non-toxic detergent, stabilizing agent.Can effectively regulate pH in product solution, buffer system can be formed to control the pH of product with the acidic materials (Peracetic acid and pyridine-2-formic acid) in system, thus play the effect of stabilizing agent.
Sodium dichloro cyanurate: be white powder or granular solid, being sterilization wide spectrum, efficient, safe disinfectant the most in oxidizing bactericide, is also the leading products in chlorated fulminuric acid class.Can the various invasive organism such as powerful kill bacteria gemma, bacterial propagule, fungi, there is special efficacy killing action to hepatitis viruse, have killing action thoroughly to sulfatereducting bacteria, iron bacteria, fungi etc.Sodium dichloro cyanurate 400-800mg is added in every 1L water, soaking disinfection 2min all can kill Escherichia coli, more than 8min can reach more than 98% to the killing rate of bacillus, 15min thoroughly can kill hepatitis b virus s antigen, in addition, sodium dichloro cyanurate also can be used for the sterilization of fruit, birds, beasts and eggs appearance, the disinfecting, deodorizing etc. of the deodorizing of refrigerator bactericide and toilet.
Sulfamic acid: be white powder, at normal temperatures, do not contact as long as keep dry with water, the sulfamic acid of solid is non-hygroscopic, more stable.The aqueous solution of sulfamic acid has the highly acid equal with hydrochloric acid, sulfuric acid etc., therefore another name is solid sulphuric acid again, and it has non-volatile, odorless and the feature minimum to human toxicity.Aqueous sulfamic acid is comparatively slow to corrosion of metal effects such as iron, can add some sodium chloride, make it to be equivalent to be converted into hydrochloric acid, thus dissolved iron is dirty effectively.Aqueous sulfamic acid can remove the water scale and corrosion product of the equipment surface that the materials such as iron, steel, copper, stainless steel manufacture.In addition, it still uniquely can be used as the acid of galvanized metal surfaces cleaning.The maximum field of current China sulfamic acid consumption is cleaning agent, and sulfamic acid is as cleaning agent, because it is solid, has storage, convenient transportation, easily the lot of advantages such as preparation, particularly suitable far way use.Amino owing to containing in sulfamic acid molecule; much more weak than inorganic acid to metal protection; if add corrosion inhibiter again in cleaning agent formula; its corrosivity can reduce further; sulfamic acid can with the reaction such as various metals salt, metal oxide, carbonate, generate soluble-salt, diaphragm can be formed in metal surface; alleviate the corrosion of metallic matrix, to remove the oxide of metal surface and dirty class material.The sulfamic acid cleaning agent scope of application is very wide.In addition, there is no the formation of solid sediment after sulfamic acid cleaning, greatly can shorten cleaning process, and as the solid strong acid of a kind of nonhygroscopic, burning and blast, transport with store all fool proof and convenient.
The present invention is used for the thimerosal of haemodialysis control unit cleaning and sterilizing compared with prior art, and tool has the following advantages and effect:
(1) transparent, the physical and chemical index stable performance of the thimerosal appearance colorless of haemodialysis control unit cleaning and sterilizing of the present invention's development, have no crystallization, muddiness, precipitation during use, every physical and chemical index performance is stable.
(2) production cost is low, preparation technology is simple, process conditions are easy to realize, and product stability is good.
(3) the present invention is used for the essentially no peculiar smell of thimerosal of haemodialysis control unit cleaning and sterilizing, environmentally safe, and be easy to accept, the disinfective action duration is long.
(4) the present invention be used for haemodialysis control unit cleaning and sterilizing thimerosal stablize, the half life period is more than 1.5 years, preservation with application in without the need to lucifuge with close, easy to use.
Embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1for a thimerosal for haemodialysis control unit cleaning and sterilizing, in components by weight percent: Peracetic acid 0.5%, hydrogen peroxide 2.0%, pyridine-2-formic acid 0.1%, sodium citrate 0.01%, sodium dichloro cyanurate 0.2%, sulfamic acid 0.05%, surplus is water.
For a preparation method for the thimerosal of haemodialysis control unit cleaning and sterilizing, step is as follows:
(1) pyridine-2-formic acid, sodium citrate and sodium dichloro cyanurate are added in Agitation Tank, after 2 minutes, add water, stir at 40 DEG C after 0.5 hour and obtain buffer solution, then the temperature of buffer solution is down to-5 DEG C;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue stirring 0.3 hour, after it fully dissolves, add sulfamic acid again, be finally diluted with water to required concentration, obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
stability test 1:get the thimerosal for haemodialysis control unit cleaning and sterilizing of above-described embodiment 1 gained, carry out stability test, storage condition with reference to " disinfection technology standard " 2002 editions: place at 37 DEG C.Testing environment: temperature 30 DEG C, relative moisture 40%-44%.Result is as shown in table 1 below:
Table 1
Proved by 37 DEG C of accelerated tests, the active ingredient Peracetic acid of the thimerosal for haemodialysis control unit cleaning and sterilizing of embodiment 1 gained and the content of hydrogen peroxide do not decline substantially, only have a small amount of hydrogen peroxide to decompose; Show the having good stability of thimerosal of the present invention for haemodialysis control unit cleaning and sterilizing, in storage and transportation, a large amount of decomposition can not occur.
embodiment 2for a thimerosal for haemodialysis control unit cleaning and sterilizing, in components by weight percent: Peracetic acid 1.0%, hydrogen peroxide 5.0%, pyridine-2-formic acid 0.5%, sodium citrate 0.05%, sodium dichloro cyanurate 2.0%, sulfamic acid 1.0%, surplus is water.
For a preparation method for the thimerosal of haemodialysis control unit cleaning and sterilizing, step is as follows:
(1) pyridine-2-formic acid, sodium citrate and sodium dichloro cyanurate are added in Agitation Tank, after 6 minutes, add water, stir at 60 DEG C after 1 hour and obtain buffer solution, then the temperature of buffer solution is down to-5-0 DEG C;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue stirring 1 hour, after it fully dissolves, add sulfamic acid again, be finally diluted with water to required concentration, obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
stability test 2:get the thimerosal for haemodialysis control unit cleaning and sterilizing of above-described embodiment 2 gained, carry out stability test, storage condition with reference to " disinfection technology standard " 2002 editions: 37 DEG C of placements.Testing environment: temperature 30 DEG C, relative moisture 40%-44%.Result is as shown in table 2 below:
Table 2
Proved by 37 DEG C of accelerated tests, the active ingredient Peracetic acid of the thimerosal for haemodialysis control unit cleaning and sterilizing of embodiment 2 gained and the content of hydrogen peroxide do not decline substantially, only have a small amount of hydrogen peroxide to decompose; Show the having good stability of thimerosal of the present invention for haemodialysis control unit cleaning and sterilizing, in storage and transportation, a large amount of decomposition can not occur.
embodiment 3for a thimerosal for haemodialysis control unit cleaning and sterilizing, in components by weight percent: Peracetic acid 0.6%, hydrogen peroxide 2.5%, pyridine-2-formic acid 0.2%, sodium citrate 0.02%, sodium dichloro cyanurate 0.5%, sulfamic acid 0.25%, surplus is water.
For a preparation method for the thimerosal of haemodialysis control unit cleaning and sterilizing, step is as follows:
(1) pyridine-2-formic acid, sodium citrate and sodium dichloro cyanurate are added in Agitation Tank, after 3 minutes, add water, stir at 45 DEG C after 0.6 hour and obtain buffer solution, then the temperature of buffer solution is down to-4 DEG C;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue stirring 0.5 hour, after it fully dissolves, add sulfamic acid again, be finally diluted with water to required concentration, obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
stability test 3:get the thimerosal for haemodialysis control unit cleaning and sterilizing prepared by above-described embodiment 3, carry out stability test, storage condition with reference to " disinfection technology standard " 2002 editions: place at 37 DEG C.Testing environment: temperature 30 DEG C, relative moisture 40%-44%.Result is as shown in table 3 below:
Table 3
Proved by 37 DEG C of accelerated tests, the active ingredient Peracetic acid of the thimerosal for haemodialysis control unit cleaning and sterilizing of embodiment 3 gained and the content of hydrogen peroxide do not decline substantially, only have a small amount of hydrogen peroxide to decompose; Show the having good stability of thimerosal of the present invention for haemodialysis control unit cleaning and sterilizing, in storage and transportation, a large amount of decomposition can not occur.
embodiment 4for a thimerosal for haemodialysis control unit cleaning and sterilizing, in components by weight percent: Peracetic acid 0.9%, hydrogen peroxide 4.5%, pyridine-2-formic acid 0.4%, sodium citrate 0.04%, sodium dichloro cyanurate 1.5%, sulfamic acid 0.8%, surplus is water.
For a preparation method for the thimerosal of haemodialysis control unit cleaning and sterilizing, step is as follows:
(1) pyridine-2-formic acid, sodium citrate and sodium dichloro cyanurate are added in Agitation Tank, after 5 minutes, add water, stir at 55 DEG C after 0.8 hour and obtain buffer solution, then the temperature of buffer solution is down to-2 DEG C;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue stirring 0.8 hour, after it fully dissolves, add sulfamic acid again, be finally diluted with water to required concentration, obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
embodiment 5for a thimerosal for haemodialysis control unit cleaning and sterilizing, in components by weight percent: Peracetic acid 0.8%, hydrogen peroxide 3.0%, pyridine-2-formic acid 0.3%, sodium citrate 0.03%, sodium dichloro cyanurate 1.0%, sulfamic acid 0.5%, surplus is water.
For a preparation method for the thimerosal of haemodialysis control unit cleaning and sterilizing, step is as follows:
(1) pyridine-2-formic acid, sodium citrate and sodium dichloro cyanurate are added in Agitation Tank, after 4 minutes, add water, stir at 50 DEG C after 0.7 hour and obtain buffer solution, then the temperature of buffer solution is down to-3 DEG C;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue stirring 0.7 hour, after it fully dissolves, add sulfamic acid again, be finally diluted with water to required concentration, obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product.
test example 1:to the thimerosal for haemodialysis control unit cleaning and sterilizing of embodiment 5 gained with bacillus subtilis black variety gemma bacterium, corynebacterium, staphylococcus, diphtheroid and the micrococcus luteus sterilization Simulation field test to medicine equipment:
Get black Bacillus suspension, corynebacterium suspension, staphylococcus suspension, diphtheroid suspension and micrococcus luteus suspension respectively to drip and contaminate in the coating of polyfluortetraethylene pipe inside evenly, be placed in 37 DEG C of constant incubators dry, prepare bacterial carrier.Then carrier is put into haemodialysis control unit pipeline, with the thimerosal for haemodialysis control unit cleaning and sterilizing of embodiment 5 gained for disinfectant, carry out cleaning and sterilizing according to haemodialysis control unit operation instructions sterilization code, result is as shown in table 4 below:
Table 4
Known with reference to " disinfection technology standard ", even if Disinfection Effect is extraordinary when reaching 4.0 to the kill oncomelania of bacterium, and as can be seen from Table 4, with the thimerosal for haemodialysis control unit cleaning and sterilizing of embodiment 5 gained, various bacteria is tested, it all reaches more than 5.50 to the kill oncomelania of bacterium, and bactericidal effect is good.
test example 2:more effective than the cleaning and sterilizing of existing disinfectant in order to verify that the present invention is used for the cleaning and sterilizing effect of the thimerosal of haemodialysis control unit cleaning and sterilizing, we have done comparative trial.Control group and experimental group are got 0.02ml black Bacillus suspension, 0.02ml corynebacterium suspension, 0.02ml staphylococcus suspension, 0.02ml diphtheroid suspension and 0.02ml micrococcus luteus suspension respectively and are dripped and contaminate in the coating of polyfluortetraethylene pipe inside evenly, be placed in 37 DEG C of constant incubators dry, prepare bacterial carrier.Then be put on haemodialysis control unit by carrier, experimental group is with the thimerosal for haemodialysis control unit cleaning and sterilizing of embodiment 5 gained for disinfectant, and control group uses other disinfectant (such as nitrofurazone, geramine etc.).Observe the sterilization rate of two groups of tests, result is as shown in table 5:
Table 5
As can be seen from the data of table 5, the sterilization rate using embodiment 5 gained to be used for the thimerosal of haemodialysis control unit cleaning and sterilizing all reaches more than 99.993%, and use the control group of other disinfectants to reach 95.578%, so the bactericidal effect of the experimental group of the thimerosal for haemodialysis control unit cleaning and sterilizing of embodiment 5 gained is used to be much better than the control group using other disinfectants.Can say, the thimerosal for haemodialysis control unit cleaning and sterilizing of gained of the present invention is a kind of better thimerosal.
With reference to embodiments of the invention, explanation is given to the present invention above.But these embodiments are only for illustrative purposes, and are not intended to limit the scope of the invention.Scope of the present invention is by claims and equivalents thereof.Do not depart from the scope of the present invention, those skilled in the art can make a variety of substitutions and modifications, and these substitutions and modifications all should fall within the scope of the present invention.
Claims (6)
1. for a preparation method for the thimerosal of haemodialysis control unit cleaning and sterilizing, it is characterized in that, comprise the following steps:
(1) pyridine-2-formic acid, sodium citrate and sodium dichloro cyanurate are added in Agitation Tank, after 3-5 minute, add water, stir at 45-55 DEG C after 0.6-0.8 hour and obtain buffer solution, then the temperature of buffer solution is down to-4 to-2 DEG C;
(2) hydrogen peroxide and Peracetic acid are added drop-wise in step (1) gained buffer solution, continue to stir 0.5-0.8 hour, after it fully dissolves, add sulfamic acid again, be finally diluted with water to required concentration, obtain thimerosal;
(3) by step (2) gained thimerosal by filtering with microporous membrane, packing and get final product, the aperture of described miillpore filter is 0.10-0.45 μm;
Gained is used for the thimerosal of haemodialysis control unit cleaning and sterilizing, and in components by weight percent: Peracetic acid 0.8%, hydrogen peroxide 3.0%, pyridine-2-formic acid 0.3%, sodium citrate 0.03%, sodium dichloro cyanurate 1.0%, sulfamic acid 0.5%, surplus is water.
2. preparation method according to claim 1, is characterized in that: step added water after (1) 4 minute.
3. preparation method according to claim 1, is characterized in that: step (1) stirs after 0.7 hour and obtains buffer solution at 50 DEG C.
4. preparation method according to claim 1, is characterized in that: buffer solution temperature is down to-3 DEG C by step (1).
5. preparation method according to claim 1, is characterized in that: step (2) continues stirring and obtains thimerosal in 0.6 hour.
6. preparation method according to claim 1, is characterized in that: step (3) aperture is 0.22 μm.
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| AU2016369505B2 (en) | 2015-12-16 | 2019-08-15 | Ecolab Usa Inc. | Peroxyformic acid compositions for membrane filtration cleaning |
| WO2017181005A1 (en) | 2016-04-15 | 2017-10-19 | Ecolab Usa Inc. | Performic acid biofilm prevention for industrial co2 scrubbers |
| BR112019010464B1 (en) | 2016-12-15 | 2024-02-06 | Ecolab Usa Inc | METHOD FOR REMOVING MICRO-ORGANISMS AND MINERAL DEPOSITS IN A MEMBRANE SYSTEM |
| CN109122715A (en) * | 2017-06-27 | 2019-01-04 | 德州绿能水处理科技有限公司 | Potassium hydrogen peroxymonosulfate compound disinfectant |
| CN107593763A (en) * | 2017-10-13 | 2018-01-19 | 吉林省富生医疗器械有限公司 | A kind of thimerosal of haemodialysis control unit and preparation method thereof |
| BR112021002549A2 (en) | 2018-08-22 | 2021-05-04 | Ecolab Usa Inc. | stabilized peroxycarboxylic acid composition, and, method of reducing a microbial population using a stabilized peroxycarboxylic acid composition. |
| CN109258641A (en) * | 2018-10-23 | 2019-01-25 | 广西润帮和医疗科技有限公司 | A kind of multifunctional disinfectant and preparation method thereof for haemodialysis control unit cleaning and sterilizing |
| CN111418601A (en) * | 2020-04-10 | 2020-07-17 | 海南万力德生物科技有限公司 | Citric acid disinfectant and preparation and application thereof |
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