CN111418601A - Citric acid disinfectant and preparation and application thereof - Google Patents
Citric acid disinfectant and preparation and application thereof Download PDFInfo
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- CN111418601A CN111418601A CN202010278721.4A CN202010278721A CN111418601A CN 111418601 A CN111418601 A CN 111418601A CN 202010278721 A CN202010278721 A CN 202010278721A CN 111418601 A CN111418601 A CN 111418601A
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- disinfectant
- citric acid
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of disinfectants, and particularly relates to a citric acid disinfectant, and preparation and application thereof. The citric acid disinfectant provided by the invention comprises the following components in parts by mass: 0.5-2 parts of guanidine disinfectant, 30-50 parts of citric acid, 20-40 parts of sodium citrate, 1-5 parts of malic acid, 1-5 parts of lactic acid, 0.04-1.0 part of benzoic acid and 50-80 parts of water. The invention does not add chlorine-containing substances, does not generate harmful residues in use and has high safety; in addition, citric acid and sodium citrate are used in a matched manner to form a stable weak acidity system, and fruit acid, lactic acid and benzoic acid are combined to maintain the weak acidity of the disinfectant, so that the irritation of the disinfectant is reduced, and the safety is improved. The embodiment shows that the citric acid disinfectant provided by the invention has killing performance on various bacteria and has lasting sterilizing performance; in addition, the citric acid disinfectant does not need to use expensive component raw materials, and the preparation cost is low.
Description
Technical Field
The invention belongs to the technical field of disinfectant, and particularly relates to a citric acid disinfectant and preparation and application thereof.
Background
Along with the improvement of the life quality of people, the hygiene consciousness of people is gradually improved, and the demand of disinfection and sterilization products is increased greatly. There is a need for disinfecting products, such as drinking water disinfection, food disinfection, disinfection of animal farming environments, skin surface disinfection, and the like.
Common disinfectants comprise chlorine-containing disinfectants such as liquid chlorine, hypochlorite and the like, and have the advantages of strong sterilization capability, low price and the like. However, chlorine disinfection generates a plurality of disinfection byproducts, and has a great risk in the processes of transportation, storage and use. In particular, when disinfected with chlorine-containing preparations, chlorine reacts readily with organic substances to form various organic halides such as trihalomethanes, and CHCl3And the like have been identified as carcinogens, which have restricted the development of sterilized products.
For another example, ethanol is a commonly used disinfectant, and has a rapid bactericidal effect due to the protein denaturation capability of the ethanol, but high-concentration ethanol has great stimulation to skin, mucous membrane, wound and wound surface, so that the application range of the disinfectant is limited.
Disclosure of Invention
In view of the above, the invention provides a citric acid disinfectant and application thereof, and the citric acid disinfectant provided by the invention has the advantages of wide bactericidal spectrum, good stability and high safety to human and animals.
In order to achieve the above purpose, the invention provides the following technical scheme:
the invention provides a citric acid disinfectant, which comprises the following components in parts by mass: 0.5-2 parts of guanidine disinfectant, 30-50 parts of citric acid, 20-40 parts of sodium citrate, 1-5 parts of malic acid, 1-5 parts of lactic acid, 0.04-1.0 part of benzoic acid and 50-80 parts of water.
Preferably, the citric acid disinfectant further comprises a solubilizer and an organic solvent.
Preferably, the organic solvent is one or more of ethanol, n-propanol, isopropanol, ethylene glycol and propylene glycol.
Preferably, the solubilizer is one or more of polyvinylpyrrolidone iodine, polyethylene glycol stearate, polyoxyethylene castor oil and polyoxyethylene hydrogenated castor oil.
Preferably, the solubilizer is 5-20 parts based on 30-50 parts of water; the mass ratio of the solubilizer to the organic solvent is 1-4: 1 to 2.
Preferably, the guanidine disinfectant is at least two of chlorhexidine gluconate, chlorhexidine acetate and polyhexamethylene biguanide.
Preferably, the mass ratio of the citric acid to the sodium citrate is 1-2: 1.
the invention provides a preparation method of the citric acid disinfectant in the technical scheme, which comprises the following steps:
mixing the components except the guanidine disinfectant to obtain primary disinfectant; and mixing the disinfectant with guanidine disinfectant to obtain the citric acid disinfectant.
The invention also provides the application of the citric acid disinfectant in the technical scheme in the disinfection of livestock breeding fields.
The invention also provides application of the citric acid disinfectant in the technical scheme in disinfection of a hemodialysis machine.
The citric acid disinfectant provided by the invention comprises the following components in parts by mass: 0.5-2 parts of guanidine disinfectant, 30-50 parts of citric acid, 20-40 parts of sodium citrate, 1-5 parts of malic acid, 1-5 parts of lactic acid, 0.04-1.0 part of benzoic acid and 50-80 parts of water. The invention does not add chlorine-containing substances, does not generate harmful residues in use and has high safety; in addition, citric acid and sodium citrate are used in a matched manner to form a stable weak acidity system, and fruit acid, lactic acid and benzoic acid are combined to maintain the weak acidity of the disinfectant, so that the irritation of the disinfectant is reduced, and the safety is improved. The guanidine disinfectant can stably and continuously exert the bactericidal property in a weak acid system, expand the antibacterial spectrum range and prevent the generation of drug-resistant strains.
The data of the embodiment show that the citric acid disinfectant provided by the invention has killing performance on various bacteria and has lasting killing performance; in addition, the citric acid disinfectant does not need to use expensive component raw materials, and the preparation cost is low.
Detailed Description
The invention provides a citric acid disinfectant, which comprises the following components in parts by mass: 0.5-2 parts of guanidine disinfectant, 30-50 parts of citric acid, 20-40 parts of sodium citrate, 1-5 parts of malic acid, 1-5 parts of lactic acid, 0.04-1.0 part of benzoic acid and 50-80 parts of water.
Unless otherwise specified, the components of the citric acid disinfectant of the present invention are commercially available products well known to those skilled in the art; the well-known products meeting the requirements of pharmacopoeia are adopted.
The citric acid disinfectant comprises, by mass, 50-80 parts of water, preferably 35-50 parts of water, and more preferably 45-50 parts of water.
Based on the mass parts of the water, the citric acid disinfectant provided by the invention comprises 0.5-2 parts of guanidine disinfectant, preferably 0.5-1 part, and further preferably 0.6-0.8 part. In the present invention, the guanidine disinfectant is preferably at least two of chlorhexidine gluconate, chlorhexidine acetate and polyhexamethylene biguanide, and is further preferably a mixture of chlorhexidine gluconate, chlorhexidine acetate and polyhexamethylene biguanide; when the guanidine disinfectant is a mixture of chlorhexidine gluconate, chlorhexidine acetate and polyhexamethylene biguanide, the mass ratio of the mixture of chlorhexidine gluconate, chlorhexidine acetate and polyhexamethylene biguanide is preferably 1:1: 1 to 3.
The guanidine disinfectant is combined with the citric acid, the sodium citrate, the malic acid and other components, so that the antibacterial property is strong and wide, and the drug-resistant bacteria are not easy to generate; the guanidine disinfectant can be rapidly and powerfully sterilized and is not influenced by the temperature, pH and the like of the use environment. In addition, the compound of chlorhexidine gluconate, chlorhexidine acetate and polyhexamethylene biguanide in a specific ratio is adopted, so that the drug effect is more durable.
The citric acid disinfectant provided by the invention comprises 30-50 parts of citric acid, preferably 30-45 parts of citric acid, and further preferably 30-40 parts of citric acid by mass of water.
The citric acid disinfectant provided by the invention comprises 20-40 parts of sodium citrate, preferably 25-40 parts of sodium citrate, and further preferably 30-40 parts of sodium citrate by mass. In the invention, the mass ratio of citric acid to sodium citrate is preferably 1-2: 1, more preferably 1: 1. on the basis of the matched use of citric acid and sodium citrate, the dosage proportion of the citric acid and the sodium citrate is further controlled, so that the weak acid environment of the citric acid disinfectant is more stable and durable.
Based on the mass parts of the water, the citric acid disinfectant provided by the invention comprises 1-5 parts of malic acid, preferably 2-4.09 parts of malic acid, and further preferably 3-4 parts of malic acid.
The citric acid disinfectant provided by the invention comprises 1-5 parts of lactic acid, preferably 2-4.77 parts of lactic acid, and more preferably 3-4 parts of lactic acid based on the mass parts of water.
The invention utilizes the solubility of lactic acid to organic matters to ensure the disinfection characteristic of the citric acid disinfectant in conventional occasions and can also fully remove organic matters such as protein and the like; moreover, the malic acid can effectively inhibit the propagation of bacteria and effectively prolong the storage life.
The citric acid disinfectant provided by the invention comprises 0.04-1.0 part of benzoic acid, preferably 0.05-0.5 part of benzoic acid, and more preferably 0.06-0.1 part of benzoic acid based on the mass parts of water.
In the present invention, the citric acid disinfectant preferably further comprises a solubilizer and an organic solvent. On the basis of the mass parts of the water, the citric acid disinfectant provided by the invention preferably comprises 5-20 parts of solubilizer, and further preferably 5-15 parts; the mass ratio of the solubilizer to the organic solvent is preferably 1-4: 1-2, more preferably 1-2: 1. in the invention, the solubilizer and the organic solvent are used in combination, so that the solubilizing effect is remarkable, and the cleaning of organic matters and the like in the application of the disinfectant is facilitated.
The invention provides a preparation method of the citric acid disinfectant in the technical scheme, which comprises the following steps:
mixing the components except the guanidine disinfectant to obtain primary disinfectant; and mixing the disinfectant with guanidine disinfectant to obtain the citric acid disinfectant.
The components except the guanidine disinfectant are mixed firstly, and then the disinfectant is prepared by mixing the obtained mixed solution with the guanidine disinfectant, so that a stable weak acid environment can be created in advance for the disinfection characteristics of the guanidine disinfectant, the guanidine disinfectant can be dissolved easily, the disinfection characteristics of the guanidine disinfectant can be maintained easily, and the lasting disinfection performance of the citric acid disinfectant can be improved.
The present invention has no particular requirement for the manner of mixing the components other than the guanidine disinfectant, and may be accomplished by solution mixing as is well known to those skilled in the art. In the invention, the citric acid is preferably provided as citric acid monohydrate, and the mass purity of the citric acid monohydrate raw material is preferably more than or equal to 99.5%; the raw material quality purity of the malic acid component is preferably more than or equal to 99%; the raw material quality purity of the lactic acid component is preferably 85-92%; the raw material quality purity of the benzoic acid component is preferably more than or equal to 99%.
The invention also provides the application of the citric acid disinfectant in the technical scheme in livestock breeding field disinfection. The invention can adopt the mode of being prepared and used at present, is not convenient to operate and can also lead the medicine to take effect quickly. In the present invention, the citric acid disinfectant is preferably applied to livestock farm disinfection in a manner that: spraying the citric acid disinfectant on the ground of the livestock farm; the spraying amount is preferably 0.5-5 g/m2More preferably 1.5 to 5g/m2. The citric acid is further preferably diluted by adding water to facilitate uniform spraying. The citric acid disinfectant is suitable for disinfecting breeding places such as cattle, sheep, horses and the like, has no irritation to livestock, and does not influence the ingestion.
The invention also provides application of the citric acid disinfectant in the technical scheme in disinfection of a hemodialysis machine. The citric acid disinfectant is preferably adopted as cleaning fluid to be circularly cleaned in the hemodialysis machine, so that bacteria in a flow path of the hemodialysis machine are removed, and organic matters such as fat, protein and the like in the flow path of the hemodialysis machine can be digested.
In order to further illustrate the present invention, the following detailed description will be made of a citric acid disinfectant and its preparation and application with reference to the examples, which should not be construed as limiting the scope of the present invention.
Example 1
Mixing the components shown in the table 1, namely mixing the components except the guanidine disinfectant under stirring, standing for 30min, adding the guanidine disinfectant, and uniformly stirring and mixing to obtain the citric acid disinfectant; wherein the guanidine disinfectant is polyhexamethylene biguanide and chlorhexidine acetate (added in equal amount).
TABLE 1 compositions and amounts (parts by mass) of citric acid disinfectant of examples 1 to 5
Example 2
The citric acid disinfectant was prepared according to the amounts shown in table 1, wherein the guanidine disinfectant was chlorhexidine gluconate and chlorhexidine acetate, and the procedure was otherwise the same as in example 1.
Example 3
Citric acid disinfectant solutions were prepared in the amounts shown in table 1, wherein the guanidine disinfectant was chlorhexidine gluconate and polyhexamethylene biguanide, otherwise the same as in example 1.
Example 4
The citric acid disinfectant solution was prepared in the amount shown in table 1, and further contains 5 parts by mass of povidone iodine and 5 parts by mass of ethanol, and the rest was the same as in example 1.
Example 5
The citric acid disinfectant solution was prepared in the amount shown in table 1, and further contains 5 parts by mass of povidone iodine, 5 parts by mass of polyoxyethylene castor oil, 5 parts by mass of isopropyl alcohol, and the same as in example 1.
Example 6
The citric acid disinfectant is prepared according to the dosage of table 1, wherein the guanidine disinfectant is a mixture of chlorhexidine gluconate, chlorhexidine acetate and polyhexamethylene biguanide, the mass ratio of the chlorhexidine gluconate to the chlorhexidine acetate to the polyhexamethylene biguanide is 1:1:2, and the rest is the same as that in example 1.
The antibacterial property of the citric acid disinfectant obtained in the examples 1 to 6 was tested:
taking water for a water plant, testing the bacteria content to be 30CFU/m L, averagely dividing the water for the test into 6 parts, dropwise adding the citric acid disinfectant obtained in the embodiment 1-6 in an amount of 0.5 g/L, testing the bacteria content in the water after one day of dropwise adding, wherein the bacteria content is respectively 3CFU/m L, 2.5CFU/m L, 2.2CFU/m L, 1.7CFU/m L, 1.0CFU/m L and 0.8CFU/m L, the visible bacteria removal rate is as high as 97.3 percent, and the water is quick in sterilization and small in dosage.
In order to further verify the property of the citric acid disinfectant for inhibiting drug-resistant bacteria, the bacteria content of 6 parts of test water is continuously detected, the obtained citric acid disinfectant is dropwise added every day, the bacteria in each part of test water do not rebound, and the bacteria content measured every day is almost equal, and the test results on the 6 th day are respectively 2.8CFU/m L, 2.8CFU/m L, 2.5CFU/m L, 1.9CFU/m L, 1.1CFU/m L and 1.2CFU/m L.
The disinfection spectrum of the citric acid disinfectant obtained in the embodiment 1-6 is verified:
bacterial suspensions of escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa are prepared, and the killing logarithm values of the disinfectant obtained in the embodiment on different bacteria are tested when the disinfectant acts for 50s at normal temperature. The test results are shown in table 2.
TABLE 2 the kill log values of the citric acid disinfectant obtained in different examples for different bacteria
As can be seen from Table 2, the citric acid disinfectant provided by the invention has excellent inhibitory effect on different bacteria and high killing efficiency.
The cleaning and disinfecting characteristics of the citric acid disinfectant hemodialysis machine obtained in the embodiment 1-6 are tested:
taking 6 dialysis machines of the same type and batch, and respectively taking light transmission tubes of the 6 dialysis machines before use to test the light transmission rate; the cleaning solution is normally used at any time, after the cleaning solution works for one week, the citric acid cleaning solutions obtained in the embodiments 1-6 are respectively adopted for cleaning, and then the light transmission tubes are removed for testing the light transmission rate; and the power of the transmission tester in the test is set to be 110 mW. Meanwhile, the bacterial content of the surface of the light-transmitting tube after cleaning is tested, and the test results are shown in table 3.
TABLE 3 transmittance of citric acid disinfectant solution obtained in different examples before and after cleaning
As can be seen from Table 3, the citric acid disinfectant provided by the invention can be used for disinfecting and cleaning the hemodialysis machine.
Meanwhile, the citric acid disinfectant obtained in the embodiments 1-6 is tested for the disinfection effect of livestock breeding sites, specifically, the bacteria content in the environment air of 4 corner of a 6-cow shed is randomly tested before the disinfectant is sprayed (a nutrient agar culture medium is placed at a specified position in advance, the number of bacterial colonies in the culture medium is tested after 60 min), then the citric acid disinfectant obtained in different embodiments is diluted according to the proportion of 1g to 1L, and then 5g/m2The amount of the disinfectant is sprayed in 6 cattle sheds (each cattle shed is sprayed with the citric acid disinfectant obtained in the same example), and the bacterial content of the same position is tested after 10min and 60 min. The test results are shown in table 4 as the average of the test at four positions.
TABLE 4 colony count in the medium before and after spraying citric acid disinfectant solution obtained in different examples (× 10)3CFU/m3)
As can be seen from Table 4, the citric acid disinfectant provided by the invention can effectively sterilize and disinfect livestock breeding sites, the sterilization rate is as high as 97.81%, and the citric acid disinfectant provided by the invention has long duration of sterilization and disinfection performance.
The embodiment shows that the citric acid disinfectant provided by the invention has the advantages of wide bactericidal spectrum, good stability and high safety to human and animals.
Although the present invention has been described in detail with reference to the above embodiments, it is only a part of the embodiments of the present invention, not all of the embodiments, and other embodiments can be obtained without inventive step according to the embodiments, and the embodiments are within the scope of the present invention.
Claims (10)
1. The citric acid disinfectant comprises the following components in parts by mass: 0.5-2 parts of guanidine disinfectant, 30-50 parts of citric acid, 20-40 parts of sodium citrate, 1-5 parts of malic acid, 1-5 parts of lactic acid, 0.04-1.0 part of benzoic acid and 50-80 parts of water.
2. The citric acid disinfectant of claim 1, further comprising a solubilizer and an organic solvent.
3. The citric acid disinfectant of claim 2, wherein the organic solvent is one or more of ethanol, n-propanol, isopropanol, ethylene glycol and propylene glycol.
4. The citric acid disinfectant of claim 2, wherein said solubilizer is one or more of povidone iodine, polyethylene glycol stearate, polyoxyethylene castor oil and polyoxyethylene hydrogenated castor oil.
5. The citric acid disinfectant as set forth in any one of claims 2 to 3, wherein said solubilizer is present in an amount of 5 to 20 parts based on 30 to 50 parts of water; the mass ratio of the solubilizer to the organic solvent is 1-4: 1 to 2.
6. The citric acid disinfectant of claim 1 wherein said guanidine disinfectant is at least two of chlorhexidine gluconate, chlorhexidine acetate, and polyhexamethylene biguanide.
7. The citric acid disinfectant solution according to claim 1, wherein the mass ratio of the citric acid to the sodium citrate is 1-2: 1.
8. the method for preparing the citric acid disinfectant as set forth in any one of claims 1 to 7, comprising the steps of:
mixing the components except the guanidine disinfectant to obtain primary disinfectant; and mixing the disinfectant with guanidine disinfectant to obtain the citric acid disinfectant.
9. Use of the citric acid disinfectant liquid according to any one of claims 1 to 7 for disinfecting livestock farm.
10. Use of the citric acid disinfectant of any one of claims 1 to 7 in hemodialysis machine disinfection.
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| CN202010278721.4A CN111418601A (en) | 2020-04-10 | 2020-04-10 | Citric acid disinfectant and preparation and application thereof |
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| CN202010278721.4A CN111418601A (en) | 2020-04-10 | 2020-04-10 | Citric acid disinfectant and preparation and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114052021A (en) * | 2021-12-09 | 2022-02-18 | 江苏奥迈生物科技有限公司 | Liquid acidity regulator for livestock and poultry farm disinfection |
| WO2023142221A1 (en) * | 2022-01-26 | 2023-08-03 | 上海交通大学 | Disinfection product based on citric acid and natural naphthoquinone compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665307A (en) * | 1991-03-27 | 1997-09-09 | Fresenius Ag | Aqueous disinfecting agent |
| CN103766377A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Citric acid decalcified disinfectant applied to dialysis machinery and water treatment and preparation method of citric acid decalcified disinfectant |
| CN104206413A (en) * | 2014-08-20 | 2014-12-17 | 张光荣 | Disinfectant for cleaning and disinfecting hemodialysis machine and preparation method of disinfectant |
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2020
- 2020-04-10 CN CN202010278721.4A patent/CN111418601A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665307A (en) * | 1991-03-27 | 1997-09-09 | Fresenius Ag | Aqueous disinfecting agent |
| CN103766377A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Citric acid decalcified disinfectant applied to dialysis machinery and water treatment and preparation method of citric acid decalcified disinfectant |
| CN104206413A (en) * | 2014-08-20 | 2014-12-17 | 张光荣 | Disinfectant for cleaning and disinfecting hemodialysis machine and preparation method of disinfectant |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114052021A (en) * | 2021-12-09 | 2022-02-18 | 江苏奥迈生物科技有限公司 | Liquid acidity regulator for livestock and poultry farm disinfection |
| WO2023142221A1 (en) * | 2022-01-26 | 2023-08-03 | 上海交通大学 | Disinfection product based on citric acid and natural naphthoquinone compound |
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