CN110637813A

CN110637813A - Aldehyde disinfectant

Info

Publication number: CN110637813A
Application number: CN201910813991.8A
Authority: CN
Inventors: 蔡美萍; 罗小清; 伍冶; 郭祥义; 赖伙发; 曹小英; 邹冰洁; 胡建华
Original assignee: JIANGXI ZHENGBANG ANIMAL HEALTH PRODUCTS CO Ltd
Current assignee: JIANGXI ZHENGBANG ANIMAL HEALTH PRODUCTS CO Ltd
Priority date: 2019-08-30
Filing date: 2019-08-30
Publication date: 2020-01-03

Abstract

The invention provides an aldehyde disinfectant, which consists of the following raw materials in percentage by weight: 3% -8% of glutaraldehyde, 3% -5% of decamethylammonium bromide, 801% -4% of tween, 1% -4% of a smell purifying agent, 3% -10% of alcohol and the balance of water. The aldehyde disinfectant has the advantages of good stability and no pungent smell, and is suitable for disinfecting farms.

Description

Aldehyde disinfectant

Technical Field

The invention relates to the technical field of disinfectants, in particular to an aldehyde disinfectant.

Background

Disinfectant means a formulation that kills pathogenic microorganisms in a transmission medium, thereby rendering it harmless. At present, the disinfectant in the market is various in types, and different disinfectants have different disinfection efficacies. In order to overcome the defect of single component, improve the disinfection effect and meet the requirements of broad spectrum, high efficiency, proper cost and the like of an ideal disinfectant as much as possible, most of the disinfectants in the market are compound disinfectants.

Glutaraldehyde is aldehyde disinfectant, and can kill bacteria propagule, spore, fungus and virus. Decamethyl ammonium bromide is a double-long-chain cationic surfactant, and quaternary ammonium cations of the decamethyl ammonium bromide can actively attract negatively charged bacteria and viruses and cover the surfaces of the negatively charged bacteria and viruses, so that the bacterial metabolism is blocked, and the permeability of a membrane is changed. The glutaraldehyde and the ammonium decamethylammonium bromide are compounded for use, so that the glutaraldehyde can easily enter bacteria and viruses, the protein and the enzyme activity are damaged, and the quick and efficient disinfection effect is achieved.

A glutaraldehyde decamethylammonium bromide compound disinfectant is available on the market, the concentration of the disinfectant is that each 100mL contains 5g of glutaraldehyde and 5g of decamethylammonium bromide, and the disinfectant is mainly used for disinfecting farms, public places and equipment instruments. Before use, the disinfectant is diluted by water according to a certain proportion, disinfected in a conventional environment, diluted by water according to the proportion of 1: 2000-4000 and sprayed; when epidemic diseases occur, the environment is disinfected, and the disinfectant and water are diluted according to the proportion of 1: 500-1000 and then sprayed. Disinfecting instruments and equipment, and diluting and soaking the instruments and the equipment with disinfectant and water according to the proportion of 1: 1500-3000.

However, the disinfectant has irritant odor and poor stability, and can be separated, suspended and turbid after long-term storage, and the sterilization effect is reduced when the disinfectant is used again.

Disclosure of Invention

The invention aims to provide an aldehyde disinfectant with good stability and no pungent smell.

In order to achieve the purpose, the aldehyde disinfectant provided by the invention comprises the following raw materials in percentage by weight: 3% -8% of glutaraldehyde, 3% -5% of decamethylammonium bromide, 801% -4% of tween, 1% -4% of a smell purifying agent, 3% -10% of alcohol and the balance of water.

Preferably, the aldehyde disinfectant consists of the following raw materials in percentage by weight: 5% of glutaraldehyde, 5% of decamethylammonium bromide, 801% of tween, 1% of smell cleaning agent, 7% of alcohol and the balance of water.

Preferably, the aldehyde disinfectant consists of the following raw materials in percentage by weight: glutaraldehyde 8%, decamethylammonium bromide 3%, tween 802%, a smell purifying agent 2%, alcohol 3% and the balance of water.

Preferably, the aldehyde disinfectant consists of the following raw materials in percentage by weight: 5% of glutaraldehyde, 3% of decamethylammonium bromide, 804% of tween, 4% of a smell purifying agent, 10% of alcohol and the balance of water.

Further, the odor purifying agent is at least one selected from geraniol, phenethyl alcohol, linalool, hydroxycitronellal alcohol and terpineol.

Further, the alcohol is one of anhydrous alcohol, 95% alcohol and 70% alcohol.

The invention has the beneficial effects that:

1. the odor purifying agent in the aldehyde disinfectant can effectively remove peculiar smell, so that the aldehyde disinfectant has no pungent smell, and the environmental comfort of the aldehyde disinfectant in use is improved.

2. The Tween 80 in the aldehyde disinfectant greatly improves the stability, and is favorable for storage and maintenance of efficient sterilization and disinfection effects.

3. The aldehyde disinfectant can effectively kill escherichia coli, staphylococcus aureus and candida albicans, and provides a good disinfection environment for a farm.

Detailed Description

The present invention will be described in further detail below with reference to examples.

[ examples 1 to 3 ]

Referring to table 1, table 1 shows the composition of the raw materials of the aldehyde-based disinfectants of examples 1 to 3 of the present invention, and the following data are the amounts of the raw materials required for preparing 100ml of the aldehyde-based disinfectants.

TABLE 1

Composition (I)	Example 1	Example 2	Example 3
				Glutaraldehyde/g	5	8	5
Decamethyl ammonium Bromide/g	5	3	3
				Tween 80/g	1	2	4
Odor eliminating agent/g	1	2	4
				Alcohol/g	7	3	10
Water (W)	Balance of	Balance of	Balance of

Wherein the odor purifying agent is at least one of geraniol, phenethyl alcohol, linalool, hydroxycitronellal alcohol and terpineol.

The alcohol is one of anhydrous alcohol, 95% alcohol and 70% alcohol.

The preparation method of the aldehyde disinfectant comprises the following steps:

s1, adding alcohol and a smell cleaning agent with corresponding weight into 50ml of water, and uniformly mixing to obtain a mixture A;

s2, adding glutaraldehyde and ammonium decamethylammonium bromide with corresponding weights into the mixture A obtained in the step S1, uniformly mixing, adding Tween 80 with corresponding weights, and uniformly mixing to obtain a mixture B;

s3, adjusting the pH value of the mixture B obtained in the step S2 to 5.10, adding water to a constant volume of 100ml, uniformly mixing, and subpackaging after passing inspection to obtain the traditional Chinese medicine composition.

[ COMPARATIVE EXAMPLES 1 to 2 ]

Referring to table 2, table 2 is a raw material composition table of the aldehyde-based disinfectant of comparative examples 1 to 2, and the following data are the amounts of raw materials required for each preparation of 100ml of the aldehyde-based disinfectant.

TABLE 2

Composition (I)	Comparative example 1	Comparative example 2
			Glutaraldehyde/g	5	5
Decamethyl ammonium Bromide/g	5	5
			Tween 80/g	0	1
Odor eliminating agent/g	1	0
			Alcohol/g	7	7
Water (W)	Balance of	Balance of

The alcohol is one of anhydrous alcohol, 95% alcohol and 70% alcohol.

Comparative examples 1-2 the preparation methods of examples 1-3 were referenced.

1. Stability test

The aldehyde disinfectants of example 1, comparative example 1 and comparative example 2 were left for 0, 5 and 10 days at high temperature (60 ℃), light (illuminance 4500LX ± 500LX) and low temperature (4 ℃), and their appearance, odor, pH, glutaraldehyde content and decamethylammonium bromide content were examined, respectively, and the test results are shown in table 3.

TABLE 3

As can be seen from comparison of the test data of example 1 and comparative example 1, the aldehyde disinfectant of example 1 added with tween 80 has the advantages of unchanged appearance and smell, small change of pH value, and small change range of the contents of the effective components glutaraldehyde and the ammonium decamethylammonium bromide after being placed for 10 days under the conditions of high temperature, illumination and low temperature, which indicates that the aldehyde disinfectant of example 1 of the present invention has good stability. The aldehyde disinfectant of the comparative example 1 without tween 80 is placed under the conditions of high temperature, light and low temperature for 10 days, the phenomena of layering, suspended matters and turbidity gradually appear, the pH value continuously rises, the pH value rises from 5.03 to 6.93 when the disinfectant is placed under the high temperature condition to the 10 th day, and the content of the effective components is greatly reduced by measuring the effective components of glutaraldehyde and decamethylammonium bromide. Therefore, the addition of the Tween 80 effectively improves the stability of the aldehyde disinfectant, and is beneficial to long-term storage.

As can be seen from comparison of experimental data of example 1 and comparative example 2, the aldehyde disinfectant of example 1 to which the odor eliminating agent was added had no pungent odor, while the aldehyde disinfectant of comparative example 2 to which the odor eliminating agent was not added had a stronger pungent odor, and it can be seen that the odor eliminating agent used in the aldehyde disinfectant of the present invention had a better odor eliminating effect.

2. Sterilization test

The aldehyde disinfectant of example 1 was diluted by a certain ratio and then subjected to a sterilization test, and the test results are shown in table 4.

TABLE 4

From the test results of table 4, it can be seen that the aldehyde disinfectant of the present invention can kill escherichia coli by 100%; the maximum dilution multiple of 100% for killing staphylococcus aureus and candida albicans is 1:10000, which shows that the aldehyde disinfectant has better sterilization effect.

Finally, it should be emphasized that the above-described preferred embodiments of the present invention are merely examples of implementations, rather than limitations, and that many variations and modifications of the invention are possible to those skilled in the art, without departing from the spirit and scope of the invention.

Claims

1. The aldehyde disinfectant is characterized by comprising the following raw materials in percentage by weight:

2. the aldehyde disinfectant as set forth in claim 1, which is characterized by comprising the following raw materials in percentage by weight:

3. the aldehyde disinfectant as set forth in claim 1, which is characterized by comprising the following raw materials in percentage by weight:

4. the aldehyde disinfectant as set forth in claim 1, which is characterized by comprising the following raw materials in percentage by weight:

5. the aldehyde disinfectant according to any one of claims 1 to 4, characterized in that:

the odor purifying agent is at least one selected from geraniol, phenethyl alcohol, linalool, hydroxycitronellal alcohol and terpineol.

6. The aldehyde disinfectant according to any one of claims 1 to 4, characterized in that:

the alcohol is one of anhydrous alcohol, 95% alcohol and 70% alcohol.