CN104940183A - Disinfectant and preparation method thereof - Google Patents
Disinfectant and preparation method thereof Download PDFInfo
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- CN104940183A CN104940183A CN201510296191.5A CN201510296191A CN104940183A CN 104940183 A CN104940183 A CN 104940183A CN 201510296191 A CN201510296191 A CN 201510296191A CN 104940183 A CN104940183 A CN 104940183A
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Abstract
The invention discloses a disinfectant and its preparation method. The disinfectant comprises a compound glutaraldehyde solution and a foaming agent. Volume ratio of the compound glutaraldehyde solution to the foaming agent is 5:1. The compound glutaraldehyde solution comprises glutaraldehyde, benzalkonium chloride, double-chain quaternary ammonium salt A, double-chain quaternary ammonium salt B, a nonionic surfactant A and a nonionic surfactant B. The double-chain quaternary ammonium salt A and the double-chain quaternary ammonium salt B are different substances. The nonionic surfactant A and the nonionic surfactant B are different substances. By cooperatively using glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of nonionic surfactants, the synergistic effect is achieved, effects are enhanced, and sterilization is comprehensive.
Description
Technical field
The present invention relates to disinfectant for animals and preparation method thereof field, in particular to a kind of disinfectant and preparation method thereof.
Background technology
Along with the continuous increase of breeding scale, the concept of " sterilization " gradually accept by numerous raisers.In Animal husbandry production, high-efficiency low-toxicity disinfectant is selected to have reality and profound significance.In control feeding environment and prevention animal epidemic, sterilization is prevention and puts out the most effective measures of infectious disease; And select desirable disinfectant, be the key carrying out Prevention of Infectious Diseases work.In in the past more than 100 year, mainly use single disinfection method agent, compound disinfectant is little.So far, chemosterilant composite has become an important research direction to earlier 2000s, and the multiple disinfectant factor is composite, can potentiation mutually, widen the antimicrobial spectrum of disinfectant, improve the killing power of disinfectant to pathogenic microorganism, define the disinfectant of a series of efficient, wide spectrum.
Glutaraldehyde belongs to high effect disinfectants, has wide spectrum, efficient, low toxicity, little to metal protection, little by organic substance influence, the features such as good stability.But it is weak to be used alone glutaraldehyde sterilization sterilizing ability under acid-base condition, poor stability.Quaternary cationic surfactant has the effect of sterilization, be widely used in disinfectant, what antibacterial in various surfactant, bactericidal property was the most excellent is cationic quaternary ammonium salt disinfection sanitizer, comprise strand quaternary ammonium salt and double-chain quaternary ammonium salt two class, strand quaternary ammonium salt can only kill some bacterial propagule and fat eliminating virus, double-chain quaternary ammonium salt then can kill multiple-microorganism, comprise bacterial propagule, fungus and virus, but single, double chain quaternary ammonium salt still cannot be killed with the use of to mycoplasma, spore.Often quaternary ammonium salt is added in glutaraldehyde class compound disinfectant, but when glutaraldehyde and strand quaternary ammonium salt benzalkonium chloride conbined usage, due to benzalkonium chloride this have certain crystallization in low temperature, the disinfectant character therefore made and stability bad, remain to be further improved; Glutaraldehyde and double-chain quaternary ammonium salt conbined usage are subject to Organic substance effect and lost efficacy.Therefore, disinfection effect all can not be satisfactory.
Summary of the invention
For above-mentioned problems of the prior art, the invention provides the disinfectant and preparation method thereof of a kind of comprehensively killing, good stability.
For achieving the above object, the invention provides following technical scheme:
A kind of disinfectant, comprise compound glutaraldehyde solution and foaming agent, the volume ratio of described compound glutaraldehyde solution and foaming agent is 5:1, described compound glutaraldehyde solution comprises: glutaraldehyde, benzalkonium chloride, double-chain quaternary ammonium salt one, double-chain quaternary ammonium salt two, non-ionic surface active agent one and non-ionic surface active agent two, described double-chain quaternary ammonium salt one is different materials from double-chain quaternary ammonium salt two, and described non-ionic surface active agent one is different materials from non-ionic surface active agent two.
Further, according to mass fraction, the each amounts of components of described compound glutaraldehyde solution is: glutaraldehyde 15%-16%, benzalkonium chloride 7%-8%, double-chain quaternary ammonium salt one 5%-6%, double-chain quaternary ammonium salt two 4%-5%, non-ionic surface active agent one 8%-9% and non-ionic surface active agent two 2%-4%, surplus is purified water.
Further, described compound glutaraldehyde solution also comprises garlicin mother solution, and mass fraction is 10%-12%.
Further, according to mass fraction, the each amounts of components of described compound glutaraldehyde solution is: glutaraldehyde 15.6%, benzalkonium chloride 7.4%, double-chain quaternary ammonium salt one 5.5%, double-chain quaternary ammonium salt 2 4.6%, non-ionic surface active agent one 8.5%, non-ionic surface active agent 2 3% and garlicin mother solution 11%, surplus is purified water.
Further, described double-chain quaternary ammonium salt one is two decyl dimethyl hydroxyethyl ammonium chloride, and described double-chain quaternary ammonium salt two is Dialkyl dimethyl ammonium chloride.
Further, the carbon atom number of the alkyl in described Dialkyl dimethyl ammonium chloride is 8-10.
Further, described non-ionic surface active agent one is fatty alcohol Ethoxylate, and described non-ionic surface active agent two is alkylphenol polyoxyethylene.
Further, described foaming agent comprises first bromine ammonium and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group in the last of the ten Heavenly stems.
Further, described last of the ten Heavenly stems first bromine ammonium and the volume ratio of gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group be 2.8:1-2.1:1.
Separately, the present invention also provides a kind of method preparing disinfectant described above, comprises the following steps:
(1) by each component mixing of compound glutaraldehyde solution, compound glutaraldehyde solution is obtained; By the last of the ten Heavenly stems first bromine ammonium and polyoxyethylene ether diacetic acid ester group gemini quaternary ammonium salt mixing, obtain foaming agent;
(2) compound glutaraldehyde solution and foaming agent are mixed according to volume ratio 5:1, adjust ph, to 3.0-4.0, obtains described disinfectant.
Beneficial effect of the present invention is as follows:
1, the present invention by glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of non-ionic surface active agents with the use of, play synergism, effect strengthens mutually, and sterilization comprehensively, all has good bactericidal effect to antibacterial, virus, mycoplasma, spore etc.;
2, the present invention by glutaraldehyde and multiple cationic surfactant and non-ionic surface active agent with the use of, make compound glutaraldehyde solution, compensate for that to be used alone glutaraldehyde sterilizing ability under acid-base condition weak, the shortcoming of poor stability; Compensate for quaternary cationic surfactant be used alone and single, double chain quaternary ammonium salt with the use of to mycoplasma, defect that spore is invalid; Also can make up glutaraldehyde simultaneously and be subject to Organic substance effect with double-chain quaternary ammonium salt conbined usage and the defect that lost efficacy; Glutaraldehyde solution is under the effect of cationic surfactant, non-ionic surface active agent, be dissolved in rapidly water and other multi-solvents, act in the feather of infiltration crack, crackle, rust, chicken and various organic pollution, and kill rapidly various pathogen by Brownian movement and electrostatic attraction active trapping;
3, the present invention by compound glutaraldehyde solution and foaming agent with the use of, foaming agent is by first bromine ammonium and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group is composite makes in the last of the ten Heavenly stems, well improve glutaraldehyde and strand quaternary ammonium salt, double-chain quaternary ammonium salt have crystallization shortcoming with the use of middle Benzalkonii Chloridum low temperature, greatly improve Disinfection Effect and the stability of disinfectant, also improve the defect that plant's equipment is easily sterilized agent corrosion;
4, the garlicin mother solution biological activity of the present invention's employing is high, fungicidal spectrum is wide, untoward reaction is very little, with glutaraldehyde, quaternary ammonium salt and non-ionic surface active agent fit applications, enhance bactericidal effect greatly, energy is pathogenic microbe killing completely, and to metal species, plastic, the corrosion-free effect of rubber, effective drug duration is long, environmental protection, belongs to safe, efficient, green novel foam disinfectant;
5, the adding of foaming agent, the visuality of sterilization is strengthened, avoid blind area of sterilizing, reduce the waste of disinfectant greatly, reduce the medicinal liquid suction volume of operator, sterilization is evenly thoroughly, enhance the gratification of operator simultaneously;
6, compound glutaraldehyde solution and foaming agent are that 5:1 uses according to volume ratio, and foaming effect is best, obviously can strengthen the bactericidal effect of compound glutaraldehyde solution;
7, the adding of gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, make glutaraldehyde, two kinds of double-chain quaternary ammonium salt cationic surfactants and two kinds of non-ionic surface active agents better play synergism, sterilization, dirt-removing power are stronger; And the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group has higher foaming capacity and steady bubble ability, and the last of the ten Heavenly stems, first bromine ammonium fit applications greatly improved foaming effect, and visuality is stronger;
8, disinfectant of the present invention also has the multiple effects such as deodorization, clean, algae removal.
Detailed description of the invention
Technical scheme of the present invention is understood better in order to make those skilled in the art; clear, complete description is carried out to technical scheme of the present invention below; based on the embodiment in the application; other roughly the same embodiment that those of ordinary skill in the art obtain under the prerequisite not making creative work, all should belong to the scope of the application's protection.
Embodiment one:
A kind of disinfectant, comprise compound glutaraldehyde solution and foaming agent, the volume ratio of described compound glutaraldehyde solution and foaming agent is 5:1, and now, foaming effect is best, obviously can strengthen the bactericidal effect of compound glutaraldehyde solution, and described compound glutaraldehyde solution comprises:
The present invention by glutaraldehyde, two kinds of cationic surfactants and two kinds of non-ionic surface active agents with the use of, make compound glutaraldehyde solution, compensate for that to be used alone glutaraldehyde sterilizing ability under acid-base condition weak, the shortcoming of poor stability; Compensate for quaternary cationic surfactant be used alone and single, double chain quaternary ammonium salt with the use of to mycoplasma, defect that spore is invalid; Also can make up glutaraldehyde simultaneously and be subject to Organic substance effect with double-chain quaternary ammonium salt conbined usage and the defect that lost efficacy; Glutaraldehyde solution is under the effect of cationic surfactant, non-ionic surface active agent, be dissolved in rapidly water and other multi-solvents, act in the feather of infiltration crack, crackle, rust, chicken and various organic pollution, and kill rapidly various pathogen by Brownian movement and electrostatic attraction active trapping.
Garlicin mother solution biological activity is high, fungicidal spectrum is wide, untoward reaction is very little, with glutaraldehyde, quaternary ammonium salt and non-ionic surface active agent fit applications, enhance bactericidal effect greatly, energy is pathogenic microbe killing completely, and to metal species, plastic, the corrosion-free effect of rubber, effective drug duration is long, environmental protection, belongs to safe, efficient, green novel foam disinfectant.
Wherein, DEQ is two decyl dimethyl hydroxyethyl ammonium chloride, and two 8-10 is the one in Dialkyl dimethyl ammonium chloride, the one in AEO-9 fatty alcohol Ethoxylate, and TX-10 is NPE, is the one in alkylphenol polyoxyethylene.The present invention by glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of non-ionic surface active agents with the use of, play synergism, effect strengthens mutually, and sterilization is comprehensively.
Foaming agent comprises: 70% the last of the ten Heavenly stems first bromine ammonium salt solution and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, volume ratio is 4:1, namely the last of the ten Heavenly stems first bromine ammonium salt solution and the volume ratio of gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group be 2.8:1.Adding of foaming agent, the visuality of sterilization is strengthened, avoid blind area of sterilizing, reduce the waste of disinfectant greatly, reduce the medicinal liquid suction volume of operator, sterilization is evenly thoroughly, enhance the gratification of operator simultaneously.
The preparation method of described disinfectant, comprises the following steps:
(1) by each component mixing of compound glutaraldehyde solution, compound glutaraldehyde solution is obtained; By 70% the last of the ten Heavenly stems first bromine ammonium salt solution and the gemini quaternary ammonium salt mixing of polyoxyethylene ether diacetic acid ester group, obtained foaming agent;
(2) compound glutaraldehyde solution and foaming agent are mixed according to volume ratio 5:1, adjust ph to 3.0, obtains described disinfectant.The present invention by compound glutaraldehyde solution and foaming agent with the use of, foaming agent is by first bromine ammonium and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group is composite makes in the last of the ten Heavenly stems, well improve glutaraldehyde and strand quaternary ammonium salt, double-chain quaternary ammonium salt have crystallization shortcoming with the use of middle Benzalkonii Chloridum low temperature, greatly improve Disinfection Effect and the stability of disinfectant, also improve the defect that plant's equipment is easily sterilized agent corrosion.
The mixing of each component of compound glutaraldehyde solution comprises the following steps:
(1) by glutaraldehyde, garlicin mother solution, AEO-9 and TX-10 mix and blend, make its mix homogeneously and dissolve completely, leaving standstill, obtain mixed liquor one;
(2) in mixed liquor one, add benzalkonium chloride, DEQ and two 8-10, stir, obtain mixed liquor two.
(3) in mixed liquor two, add purified water to 1L, obtain compound glutaraldehyde solution.
Adding of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, make two kinds of double-chain quaternary ammonium salt cationic surfactants and two kinds of non-ionic surface active agents better play synergism, sterilization, dirt-removing power are stronger; And the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group has higher foaming capacity and steady bubble ability, and the last of the ten Heavenly stems, first bromine ammonium fit applications greatly improved foaming effect, and visuality is stronger.
Disinfectant of the present invention also has the multiple effects such as deodorization, clean, algae removal.
Embodiment two:
A kind of disinfectant, comprise compound glutaraldehyde solution and foaming agent, the volume ratio of described compound glutaraldehyde solution and foaming agent is 5:1, and now, foaming effect is best, obviously can strengthen the bactericidal effect of compound glutaraldehyde solution, and described compound glutaraldehyde solution comprises:
The present invention by glutaraldehyde, two kinds of cationic surfactants and two kinds of non-ionic surface active agents with the use of, make compound glutaraldehyde solution, compensate for that to be used alone glutaraldehyde sterilizing ability under acid-base condition weak, the shortcoming of poor stability; Compensate for quaternary cationic surfactant be used alone and single, double chain quaternary ammonium salt with the use of to mycoplasma, defect that spore is invalid; Also can make up glutaraldehyde simultaneously and be subject to Organic substance effect with double-chain quaternary ammonium salt conbined usage and the defect that lost efficacy; Glutaraldehyde solution is under the effect of cationic surfactant, non-ionic surface active agent, be dissolved in rapidly water and other multi-solvents, act in the feather of infiltration crack, crackle, rust, chicken and various organic pollution, and kill rapidly various pathogen by Brownian movement and electrostatic attraction active trapping.
Garlicin mother solution biological activity is high, fungicidal spectrum is wide, untoward reaction is very little, with glutaraldehyde, quaternary ammonium salt and non-ionic surface active agent fit applications, enhance bactericidal effect greatly, energy is pathogenic microbe killing completely, and to metal species, plastic, the corrosion-free effect of rubber, effective drug duration is long, environmental protection, belongs to safe, efficient, green novel foam disinfectant.
Wherein, DEQ is two decyl dimethyl hydroxyethyl ammonium chloride, and two 8-10 is the one in Dialkyl dimethyl ammonium chloride, and AEO-9 is the one in fatty alcohol Ethoxylate, and TX-10 is NPE, is the one in alkylphenol polyoxyethylene.The present invention by glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of non-ionic surface active agents with the use of, play synergism, effect strengthens mutually, and sterilization is comprehensively.
Foaming agent comprises: 70% the last of the ten Heavenly stems first bromine ammonium salt solution and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, volume ratio is 4:1, namely the last of the ten Heavenly stems first bromine ammonium salt solution and the volume ratio of gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group be 2.8:1.Adding of foaming agent, the visuality of sterilization is strengthened, avoid blind area of sterilizing, reduce the waste of disinfectant greatly, reduce the medicinal liquid suction volume of operator, sterilization is evenly thoroughly, enhance the gratification of operator simultaneously.
The preparation method of described disinfectant, comprising:
(1) by each component mixing of compound glutaraldehyde solution, compound glutaraldehyde solution is obtained; By 70% the last of the ten Heavenly stems first bromine ammonium salt solution and the gemini quaternary ammonium salt mixing of polyoxyethylene ether diacetic acid ester group, obtained foaming agent;
(2) compound glutaraldehyde solution and foaming agent are mixed according to volume ratio 5:1, adjust ph to 3.5, obtains described disinfectant.The present invention by compound glutaraldehyde solution and foaming agent with the use of, foaming agent is by first bromine ammonium and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group is composite makes in the last of the ten Heavenly stems, well improve glutaraldehyde and strand quaternary ammonium salt, double-chain quaternary ammonium salt have crystallization shortcoming with the use of middle Benzalkonii Chloridum low temperature, greatly improve Disinfection Effect and the stability of disinfectant, also improve the defect that plant's equipment is easily sterilized agent corrosion.
The mixing of each component of compound glutaraldehyde solution comprises the following steps:
(1) by glutaraldehyde, garlicin mother solution, AEO-9 and TX-10 mix and blend, make its mix homogeneously and dissolve completely, leaving standstill, obtain mixed liquor one;
(2) in mixed liquor one, add benzalkonium chloride, DEQ and two 8-10, stir, obtain mixed liquor two.
(3) in mixed liquor two, add purified water to 1L, obtain compound glutaraldehyde solution.
Adding of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, make two kinds of double-chain quaternary ammonium salt cationic surfactants and two kinds of non-ionic surface active agents better play synergism, sterilization, dirt-removing power are stronger; And the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group has higher foaming capacity and steady bubble ability, and the last of the ten Heavenly stems, first bromine ammonium fit applications greatly improved foaming effect, and visuality is stronger.
Disinfectant of the present invention also has the multiple effects such as deodorization, clean, algae removal.
Embodiment three:
A kind of disinfectant, comprise compound glutaraldehyde solution and foaming agent, the volume ratio of described compound glutaraldehyde solution and foaming agent is 5:1, and now, foaming effect is best, obviously can strengthen the bactericidal effect of compound glutaraldehyde solution, and described compound glutaraldehyde solution comprises:
The present invention by glutaraldehyde, two kinds of cationic surfactants and two kinds of non-ionic surface active agents with the use of, make compound glutaraldehyde solution, compensate for that to be used alone glutaraldehyde sterilization sterilizing ability under acid-base condition weak, the shortcoming of poor stability; Compensate for quaternary cationic surfactant be used alone and single, double chain quaternary ammonium salt with the use of to mycoplasma, defect that spore is invalid; Also can make up glutaraldehyde simultaneously and be subject to Organic substance effect with double-chain quaternary ammonium salt conbined usage and the defect that lost efficacy; Glutaraldehyde solution is under the effect of cationic surfactant, non-ionic surface active agent, be dissolved in rapidly water and other multi-solvents, act in the feather of infiltration crack, crackle, rust, chicken and various organic pollution, and kill rapidly various pathogen by Brownian movement and electrostatic attraction active trapping.
Garlicin mother solution biological activity is high, fungicidal spectrum is wide, untoward reaction is very little, with glutaraldehyde, quaternary ammonium salt and non-ionic surface active agent fit applications, enhance bactericidal effect greatly, energy is pathogenic microbe killing completely, and to metal species, plastic, the corrosion-free effect of rubber, effective drug duration is long, environmental protection, belongs to safe, efficient, green novel foam disinfectant.
Wherein, DEQ is two decyl dimethyl hydroxyethyl ammonium chloride, and two 8-10 is the one in Dialkyl dimethyl ammonium chloride, and AEO-9 is the one in fatty alcohol Ethoxylate, and TX-10 is NPE, is the one in alkylphenol polyoxyethylene.The present invention by glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of non-ionic surface active agents with the use of, play synergism, effect strengthens mutually, and sterilization is comprehensively.
Foaming agent comprises: 70% the last of the ten Heavenly stems first bromine ammonium salt solution and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, volume ratio is 3.5:1, namely the last of the ten Heavenly stems first bromine ammonium salt solution and the volume ratio of gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group be 2.45:1.Adding of foaming agent, the visuality of sterilization is strengthened, avoid blind area of sterilizing, reduce the waste of disinfectant greatly, reduce the medicinal liquid suction volume of operator, sterilization is evenly thoroughly, enhance the gratification of operator simultaneously.
The preparation method of described disinfectant, comprising:
(1) by each component mixing of compound glutaraldehyde solution, compound glutaraldehyde solution is obtained; By 70% the last of the ten Heavenly stems first bromine ammonium salt solution and the gemini quaternary ammonium salt mixing of polyoxyethylene ether diacetic acid ester group, obtained foaming agent;
(2) compound glutaraldehyde solution and foaming agent are mixed according to volume ratio 5:1, adjust ph to 3.2, obtains described disinfectant.The present invention by compound glutaraldehyde solution and foaming agent with the use of, foaming agent is by first bromine ammonium and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group is composite makes in the last of the ten Heavenly stems, well improve glutaraldehyde and strand quaternary ammonium salt, double-chain quaternary ammonium salt have crystallization shortcoming with the use of middle Benzalkonii Chloridum low temperature, greatly improve Disinfection Effect and the stability of disinfectant, also improve the defect that plant's equipment is easily sterilized agent corrosion.
The mixing of each component of compound glutaraldehyde solution comprises the following steps:
(1) by glutaraldehyde, garlicin mother solution, AEO-9 and TX-10 mix and blend, make its mix homogeneously and dissolve completely, leaving standstill, obtain mixed liquor one;
(2) in mixed liquor one, add benzalkonium chloride, DEQ and two 8-10, stir, obtain mixed liquor two.
(3) in mixed liquor two, add purified water to 1L, obtain compound glutaraldehyde solution.
Adding of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, make two kinds of double-chain quaternary ammonium salt cationic surfactants and two kinds of non-ionic surface active agents better play synergism, sterilization, dirt-removing power are stronger; And the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group has higher foaming capacity and steady bubble ability, and the last of the ten Heavenly stems, first bromine ammonium fit applications greatly improved foaming effect, and visuality is stronger.
Disinfectant of the present invention also has the multiple effects such as deodorization, clean, algae removal.
Embodiment four:
A kind of disinfectant, comprise compound glutaraldehyde solution and foaming agent, the volume ratio of described compound glutaraldehyde solution and foaming agent is 5:1, and now, foaming effect is best, obviously can strengthen the bactericidal effect of compound glutaraldehyde solution, and described compound glutaraldehyde solution comprises:
The present invention by glutaraldehyde, two kinds of cationic surfactants and two kinds of non-ionic surface active agents with the use of, make compound glutaraldehyde solution, compensate for that to be used alone glutaraldehyde sterilization sterilizing ability under acid-base condition weak, the shortcoming of poor stability; Compensate for quaternary cationic surfactant be used alone and single, double chain quaternary ammonium salt with the use of to mycoplasma, defect that spore is invalid; Also can make up glutaraldehyde simultaneously and be subject to Organic substance effect with double-chain quaternary ammonium salt conbined usage and the defect that lost efficacy; Glutaraldehyde solution is under the effect of cationic surfactant, non-ionic surface active agent, be dissolved in rapidly water and other multi-solvents, act in the feather of infiltration crack, crackle, rust, chicken and various organic pollution, and kill rapidly various pathogen by Brownian movement and electrostatic attraction active trapping.
Garlicin mother solution biological activity is high, fungicidal spectrum is wide, untoward reaction is very little, with glutaraldehyde, quaternary ammonium salt and non-ionic surface active agent fit applications, enhance bactericidal effect greatly, energy is pathogenic microbe killing completely, and to metal species, plastic, the corrosion-free effect of rubber, effective drug duration is long, environmental protection, belongs to safe, efficient, green novel foam disinfectant.
Wherein, DEQ is two decyl dimethyl hydroxyethyl ammonium chloride, and two 8-10 is the one in Dialkyl dimethyl ammonium chloride, and AEO-9 is the one in fatty alcohol Ethoxylate, and TX-10 is NPE, is the one in alkylphenol polyoxyethylene.The present invention by glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of non-ionic surface active agents with the use of, play synergism, effect strengthens mutually, and sterilization is comprehensively.
Foaming agent comprises: 70% the last of the ten Heavenly stems first bromine ammonium salt solution and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, volume ratio is 3:1, namely the last of the ten Heavenly stems first bromine ammonium salt solution and the volume ratio of gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group be 2.1:1.Adding of foaming agent, the visuality of sterilization is strengthened, avoid blind area of sterilizing, reduce the waste of disinfectant greatly, reduce the medicinal liquid suction volume of operator, sterilization is evenly thoroughly, enhance the gratification of operator simultaneously.
The preparation method of described disinfectant, comprising:
(1) by each component mixing of compound glutaraldehyde solution, compound glutaraldehyde solution is obtained; By 70% the last of the ten Heavenly stems first bromine ammonium salt solution and the gemini quaternary ammonium salt mixing of polyoxyethylene ether diacetic acid ester group, obtained foaming agent;
(2) compound glutaraldehyde solution and foaming agent are mixed according to volume ratio 5:1, adjust ph to 3.0, obtains described disinfectant.The present invention by compound glutaraldehyde solution and foaming agent with the use of, foaming agent is by first bromine ammonium and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group is composite makes in the last of the ten Heavenly stems, well improve glutaraldehyde and strand quaternary ammonium salt, double-chain quaternary ammonium salt have crystallization shortcoming with the use of middle Benzalkonii Chloridum low temperature, greatly improve Disinfection Effect and the stability of disinfectant, also improve the defect that plant's equipment is easily sterilized agent corrosion.
The mixing of each component of compound glutaraldehyde solution comprises the following steps:
(1) by glutaraldehyde, garlicin mother solution, AEO-9 and TX-10 mix and blend, make its mix homogeneously and dissolve completely, leaving standstill, obtain mixed liquor one;
(2) in mixed liquor one, add benzalkonium chloride, DEQ and two 8-10, stir, obtain mixed liquor two.
(3) in mixed liquor two, add purified water to 1L, obtain compound glutaraldehyde solution.
Adding of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, make two kinds of double-chain quaternary ammonium salt cationic surfactants and two kinds of non-ionic surface active agents better play synergism, sterilization, dirt-removing power are stronger; And the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group has higher foaming capacity and steady bubble ability, and the last of the ten Heavenly stems, first bromine ammonium fit applications greatly improved foaming effect, and visuality is stronger.
Disinfectant of the present invention also has the multiple effects such as deodorization, clean, algae removal.
Contrast test one:
The preparation of bacteria suspension: escherichia coli (ATCC8099), staphylococcus aureus (ATCC6538), (ATCC10231), the bacillus subtilis (ATCC6633) of Candida albicans, mycoplasma hyorhinis (ATCC17981) fresh slant culture, washes down with diluent (tryptone normal saline solution) 5mL and is mixed with bacteria suspension.During test, bacteria suspension and 3% bovine serum albumin are done half-and-half to dilute.
By DEQ, two 8-10, AEO-9 purified water is dissolved, TX-10 purified water is diluted, obtain the DEQ that concentration is 40mg/L, two 8-10, AEO-9 and solution, obtain 13 groups of experimental grouies separately or after mutually combining, glutaraldehyde solution is added in each group experimental group, addition is 15% of overall solution volume, then 13 groups of experimental grouies are acted on staphylococcus aureus respectively, escherichia coli, Candida albicans, the bacteria suspension 20min of bacillus subtilis and mycoplasma hyorhinis, sampling also pours into inoculation by culture medium, cultivate under 37 DEG C of conditions, for staphylococcus aureus, escherichia coli cultivate 48h, for Candida albicans, bacillus subtilis and mycoplasma hyorhinis cultivate 72h.
Matched group: replace disinfectant solution with diluent (tryptone normal saline solution), test by above-mentioned same step.Acquired results represents the original concentration of bacterium liquid, using it as the initial concentration calculating sterilization logarithm.Result is as shown in table 1.
Calculate the viable bacteria concentration (cfumL of each group
-1), and be scaled logarithm value, be calculated as follows kill oncomelania.
Logarithm value-experimental group viable bacteria concentration the logarithm value of kill oncomelania (KL)=matched group viable bacteria concentration.
KL value is when micro organism quantity is expressed in logarithmic, and the logarithm value that before and after disinfection, microorganism reduces, KL value represents the power of disinfectant sterilizing ability.KL value is larger, and the sterilizing ability of disinfectant is stronger, otherwise, more weak.
Table 1: the KL value using different surfaces activating agent
This experimental data is provided by Shandong Sinder Technology Co., Ltd.'s laboratory
As can be seen from Table 1, be used alone wherein any one surfactant and all can not reach good bactericidal effect, and will wherein any two or three combinationally use after, the sterilizing ability of compositions improves, after glutaraldehyde, DEQ, two 8-10, AEO-9 and TX-10 combination, bactericidal effect significantly improves, and four serve obvious synergistic function with glutaraldehyde, and sterilizing ability significantly improves.
Contrast test two:
Test method:
With artificial contaminated bacteria samples metope for sterilization objects, antibacterial used is escherichia coli 8099.During microbiological contamination, select the position that article are more flat, wipe with sterile cotton in dimension board central authorities space and be stained with 3 blocks on the tested surface of bacteria suspension uniform application that (area is respectively for 25cm
2).The preparation method of bacteria suspension, with contrast test one, is tested after natural drying.
Each group of disinfectant is sparged body surface by finite concentration dilution carry out disinfection.After sterilization, wiped by sterile cotton in bedewing containing in 5ml nertralizer (nertralizer is 500mlPBS+2.5g glycine+2.5g lecithin+2.5g Tween 80) test tube, carry out swabing sampling to 3 sterilization blocks respectively, every block comes and goes each 8 times anyhow.After sampling, in sterile working's mode, cotton is wiped sampling end and cut into former nertralizer in vitro, rapping 200 times, effect 10min.Suitably dilution is done if desired with nertralizer.Every part, sample is drawn 1.0ml, and with agar tilt-pour process inoculation plate, 1 plate inoculated by each sample, puts in 37 DEG C of calorstats and cultivates 48h, observes final result.
70% the last of the ten Heavenly stems first bromine ammonium salt solution and polyoxyethylene ether diacetic acid ester group gemini quaternary ammonium salt using 4:1 volume ratio mixing test as foaming agent, matched group is divided into 5 groups: peace kills spraying group (1:200 doubly dilutes), compound glutaraldehyde solution spray group (1:200 doubly dilutes), (1:100 doubly dilutes compound glutaraldehyde solution+last of the ten Heavenly stems first bromine ammonium foam group, 5L compound glutaraldehyde+70% first in last of the ten Heavenly stems bromine ammonium salt solution 1L), (1:100 doubly dilutes the gemini quaternary ammonium salt foam group of compound glutaraldehyde solution+polyoxyethylene ether diacetic acid ester group, the gemini quaternary ammonium salt 1kg of 5L compound glutaraldehyde+polyoxyethylene ether diacetic acid ester group), (1:350 doubly dilutes foaming agent group, 70% the last of the ten Heavenly stems first bromine ammonium 4L+ oxygen vinyl Ether diacetic acid ester group gemini quaternary ammonium salt 1kg).Each component and the amounts of components of this contrast test each matched group disinfectant compound glutaraldehyde solution used and the embodiment of the present invention two compound glutaraldehyde solution are identical.Experimental group is the embodiment of the present invention one to four, and compound glutaraldehyde solution+foaming agent (1:200 doubly dilutes), each group sterilizing rate result is as following table 2.
Table 2: the bactericidal effect of different disinfectant
This experimental data is provided by Shandong Sinder Technology Co., Ltd.'s laboratory
As can be seen from Table 2, except the present invention's (compound glutaraldehyde+foaming agent foam group) can reach almost except 100% sterilizing rate, all can not kill completely the escherichia coli of this test for all the other each group.Further, it is also the composite antibacterial of glutaraldehyde and quaternary ammonium salt that peace is killed, and its sterilizing rate is only 94.7%, and the bactericidal effect of compound glutaraldehyde solution spray group of the present invention is 96.7%, kills apparently higher than peace.Select separately first bromine ammonium or the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group when foaming in the last of the ten Heavenly stems, all lower than the sterilizing rate of both combinations as foaming agent, therefore, composite foaming agent of the present invention and compound glutaraldehyde solution with the use of, significantly enhance the disinfection effect of disinfectant of the present invention, can play antibacterial and almost 100% kill.In addition, the bactericidal effect of the embodiment of the present invention one to four is all better than existing disinfectant peace and kills, and bactericidal effect of the present invention is described compared with prior art, is really improved.Further, for general disinfectant on the market, it is very difficult that sterilizing rate reaches more than 98%, and the sterilizing rate of the embodiment of the present invention one to four is all more than 98%, almost can reach 100% to the sterilizing rate of antibacterial.
From contrast test one, disinfectant of the present invention all has good bactericidal effect to staphylococcus aureus, Candida albicans, mycoplasma, spore etc., its sterilization mechanism with to colibacillary identical or similar, therefore, the bactericidal effect of this contrast test can represent the present invention to other antibacterials and viral bactericidal effect.
Test three:
Disinfectant stability test test reference Chinese veterinary pharmacopoeia version in 2010 annex, paper examines its appearance character, acid-base value, clarity of solution and color, clarity, related substance and content under high temperature, illumination and deepfreeze condition.
The disinfectant that disinfectant and the embodiment of the present invention two killed to peace 60 DEG C, 4500LX ± 500LX illuminance, to place under deepfreeze condition, detect indices in sampling in the 5th, 10 day, compare with the data of 0 day, the results are shown in following table 3 and table 4.
Table 3 disinfectant stability test of the present invention result
This experimental data is provided by Shandong Sinder Technology Co., Ltd.'s laboratory
Table 4 peace kills stability test result
This experimental data is provided by Shandong Sinder Technology Co., Ltd.'s laboratory
From table 3 result of the test, after the disinfectant of the embodiment of the present invention two entered high temperature, low temperature and photo-irradiation treatment, the measurement result of its indices all conforms with the regulations, effective ingredient glutaraldehyde and garlicin major part all stable existences, its pH value range is still 3.0 ~ 4.0, outward appearance and clarity have no significant change, and disinfectant good stability of the present invention is described.
From table 4 result of the test, peace kills placement 10 days, after high temperature, low temperature and illumination, its effective ingredient glutaraldehyde decomposes in a large number, occurs color change, precipitation and muddiness, the poor stability of pacifying and killing is described, high temperature, low temperature and illumination all can affect its stability, cause its sterilizing rate to reduce.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (10)
1. a disinfectant, it is characterized in that, comprise compound glutaraldehyde solution and foaming agent, the volume ratio of described compound glutaraldehyde solution and foaming agent is 5:1, described compound glutaraldehyde solution comprises: glutaraldehyde, benzalkonium chloride, double-chain quaternary ammonium salt one, double-chain quaternary ammonium salt two, non-ionic surface active agent one and non-ionic surface active agent two, described double-chain quaternary ammonium salt one is different materials from double-chain quaternary ammonium salt two, and described non-ionic surface active agent one is different materials from non-ionic surface active agent two.
2. disinfectant according to claim 1, it is characterized in that, according to mass fraction, the each amounts of components of described compound glutaraldehyde solution is: glutaraldehyde 15%-16%, benzalkonium chloride 7%-8%, double-chain quaternary ammonium salt one 5%-6%, double-chain quaternary ammonium salt two 4%-5%, non-ionic surface active agent one 8%-9% and non-ionic surface active agent two 2%-4%, surplus is purified water.
3. disinfectant according to claim 2, is characterized in that, described compound glutaraldehyde solution also comprises garlicin mother solution, and mass fraction is 10%-12%.
4. disinfectant according to claim 3, it is characterized in that, according to mass fraction, the each amounts of components of described compound glutaraldehyde solution is: glutaraldehyde 15.6%, benzalkonium chloride 7.4%, double-chain quaternary ammonium salt one 5.5%, double-chain quaternary ammonium salt 2 4.6%, non-ionic surface active agent one 8.5%, non-ionic surface active agent 2 3% and garlicin mother solution 11%, surplus is purified water.
5. according to the arbitrary described disinfectant of claim 1-4, it is characterized in that, described double-chain quaternary ammonium salt one is two decyl dimethyl hydroxyethyl ammonium chloride, and described double-chain quaternary ammonium salt two is Dialkyl dimethyl ammonium chloride.
6. disinfectant according to claim 5, is characterized in that, the carbon atom number of the alkyl in described Dialkyl dimethyl ammonium chloride is 8-10.
7., according to the arbitrary described disinfectant of claim 1-4, it is characterized in that, described non-ionic surface active agent one is fatty alcohol Ethoxylate, and described non-ionic surface active agent two is alkylphenol polyoxyethylene.
8. according to the arbitrary described disinfectant of claim 1-4, it is characterized in that, described foaming agent comprises first bromine ammonium and the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group in the last of the ten Heavenly stems.
9. disinfectant according to claim 8, is characterized in that, described last of the ten Heavenly stems first bromine ammonium and the volume ratio of gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group be 2.8:1-2.1:1.
10. prepare as arbitrary in claim 1-9 as described in the method for disinfectant, it is characterized in that, comprise the following steps:
(1) by each component mixing of compound glutaraldehyde solution, compound glutaraldehyde solution is obtained; By the last of the ten Heavenly stems first bromine ammonium and polyoxyethylene ether diacetic acid ester group gemini quaternary ammonium salt mixing, obtain foaming agent;
(2) compound glutaraldehyde solution and foaming agent are mixed according to volume ratio 5:1, adjust ph, to 3.0-4.0, obtains described disinfectant.
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| CN105961386A (en) * | 2016-05-06 | 2016-09-28 | 佛山科学技术学院 | Glutaraldehyde foam disinfectant and preparation method thereof |
| CN106135202A (en) * | 2016-06-17 | 2016-11-23 | 广州市兴达动物药业有限公司 | The preparation method of a kind of foamaseptic and using method thereof |
| EP3410854A4 (en) * | 2016-02-05 | 2019-07-03 | Dow Global Technologies Llc | Microbicidal composition |
| CN110637813A (en) * | 2019-08-30 | 2020-01-03 | 江西正邦动物保健品有限公司 | Aldehyde disinfectant |
| CN113197202A (en) * | 2021-05-14 | 2021-08-03 | 湖南伟达科技有限公司 | Composite glutaraldehyde foam disinfectant and preparation method thereof |
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| CN115039774A (en) * | 2022-06-29 | 2022-09-13 | 苏州艾科尔化工科技有限公司 | Compound disinfectant for controlling banana march disease and panama disease and application thereof |
| CN115885991A (en) * | 2022-11-08 | 2023-04-04 | 四川成康动物药业有限公司 | Disinfectant composition and production process thereof |
| CN115039774B (en) * | 2022-06-29 | 2024-04-30 | 苏州艾科尔化工科技有限公司 | Compound disinfectant for controlling banana equine diseases and panama diseases and application thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3410854A4 (en) * | 2016-02-05 | 2019-07-03 | Dow Global Technologies Llc | Microbicidal composition |
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| CN110637813A (en) * | 2019-08-30 | 2020-01-03 | 江西正邦动物保健品有限公司 | Aldehyde disinfectant |
| CN113331186A (en) * | 2021-04-26 | 2021-09-03 | 广州迈高化学有限公司 | Foam disinfectant and preparation method thereof |
| CN113197202A (en) * | 2021-05-14 | 2021-08-03 | 湖南伟达科技有限公司 | Composite glutaraldehyde foam disinfectant and preparation method thereof |
| CN115039774A (en) * | 2022-06-29 | 2022-09-13 | 苏州艾科尔化工科技有限公司 | Compound disinfectant for controlling banana march disease and panama disease and application thereof |
| CN115039774B (en) * | 2022-06-29 | 2024-04-30 | 苏州艾科尔化工科技有限公司 | Compound disinfectant for controlling banana equine diseases and panama diseases and application thereof |
| CN115885991A (en) * | 2022-11-08 | 2023-04-04 | 四川成康动物药业有限公司 | Disinfectant composition and production process thereof |
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