CN104940183B - A kind of disinfectant and preparation method thereof - Google Patents
A kind of disinfectant and preparation method thereof Download PDFInfo
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- CN104940183B CN104940183B CN201510296191.5A CN201510296191A CN104940183B CN 104940183 B CN104940183 B CN 104940183B CN 201510296191 A CN201510296191 A CN 201510296191A CN 104940183 B CN104940183 B CN 104940183B
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- quaternary ammonium
- ammonium salt
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- disinfectant
- glutaraldehyde solution
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 66
- 238000002360 preparation method Methods 0.000 title abstract description 12
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims abstract description 130
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 99
- 150000001875 compounds Chemical class 0.000 claims abstract description 77
- 239000004088 foaming agent Substances 0.000 claims abstract description 52
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 46
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 15
- 239000000126 substance Substances 0.000 claims abstract description 7
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 claims abstract 3
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 44
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 44
- -1 alkyl dimethyl chlorine Chemical compound 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 claims description 14
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 claims description 14
- 235000010081 allicin Nutrition 0.000 claims description 14
- 239000012452 mother liquor Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 10
- 239000008213 purified water Substances 0.000 claims description 9
- RLGGVUPWOJOQHP-UHFFFAOYSA-M decyl-(2-hydroxyethyl)-dimethylazanium;chloride Chemical class [Cl-].CCCCCCCCCC[N+](C)(C)CCO RLGGVUPWOJOQHP-UHFFFAOYSA-M 0.000 claims description 6
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical group Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 231100000167 toxic agent Toxicity 0.000 claims description 5
- 239000003440 toxic substance Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000000373 fatty alcohol group Chemical group 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 55
- 230000001954 sterilising effect Effects 0.000 abstract description 37
- 230000000694 effects Effects 0.000 abstract description 35
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 239000000243 solution Substances 0.000 description 93
- 230000000844 anti-bacterial effect Effects 0.000 description 20
- 241000894006 Bacteria Species 0.000 description 17
- 238000005187 foaming Methods 0.000 description 17
- 239000003093 cationic surfactant Substances 0.000 description 15
- 230000007547 defect Effects 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 13
- 239000006260 foam Substances 0.000 description 12
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 10
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 10
- 230000002708 enhancing effect Effects 0.000 description 10
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 10
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 238000002425 crystallisation Methods 0.000 description 6
- 230000008025 crystallization Effects 0.000 description 6
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 5
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of disinfectant and preparation method thereof, including compound glutaraldehyde solution and foaming agent, the volume ratio of the compound glutaraldehyde solution and foaming agent is 5:1, the compound glutaraldehyde solution includes：Glutaraldehyde, benzalkonium chloride, double-chain quaternary ammonium salt one, double-chain quaternary ammonium salt two, nonionic surfactant one and nonionic surfactant two, the double-chain quaternary ammonium salt one is different substances from double-chain quaternary ammonium salt two, the nonionic surfactant one is different substances from nonionic surfactant two, glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of nonionic surfactants are used cooperatively by the present invention, play synergistic effect, effect mutually enhances, and sterilization is comprehensive.
Description
Technical field
The present invention relates to disinfectant for animals and preparation method thereof fields, in particular to a kind of disinfectant and its preparation
Method.
Background technology
With being continuously increased for breeding scale, the concept of " disinfection " is gradually received by numerous raisers.In animal husbandry
In production, selection high-efficiency low-toxicity disinfectant profound significance with practical.In control feeding environment and in preventing animal epidemic,
Disinfection is to prevent and put out the most effective measure of infectious disease；And ideal disinfectant is selected, carry out Prevention of Infectious Diseases work
It is crucial.In past more than 100 years, mainly use single disinfection method agent, compound disinfectant seldom.Earlier 2000s so far,
The compounding of chemosterilant has become an important research direction, a variety of disinfectant factors compoundings, can mutual synergy, widen
The antimicrobial spectrum of disinfectant improves killing power of the disinfectant to pathogenic microorganism, forms a series of efficient, wide spectrum disinfections
Agent.
Glutaraldehyde belongs to high effect disinfectants, have wide spectrum, efficiently, low toxicity, it is small to metal protection, by organic substance influence
It is small, the features such as stability is good.But exclusive use glutaraldehyde disinfection sterilizing ability under acid-base condition is weak, and stability is poor.Quaternary ammonium salt
Cationoid surfactant has the function of sterilization, is widely used in disinfectant, presses down in various surfactants
Bacterium, bactericidal property it is most excellent be cationic quaternary ammonium salt disinfection sanitizer, including two class of single-stranded quaternary ammonium salt and double-chain quaternary ammonium salt,
Single-stranded quaternary ammonium salt can only kill certain bacterial propagules and fat eliminating virus, and double-chain quaternary ammonium salt can then kill multiple-microorganism, including
Bacterial propagule, fungi and virus, but single, double chain quaternary ammonium salt is with the use of can not still kill mycoplasma, gemma.Penta 2
Often add quaternary ammonium salt in aldehydes compound disinfectant, but when glutaraldehyde is used in combination with single-stranded quaternary ammonium salt benzalkonium chloride, due to
Benzalkonium chloride itself has certain crystallization to be precipitated in low temperature, therefore manufactured disinfectant character and stability are bad, need into one
Step improves；Glutaraldehyde is used in combination with double-chain quaternary ammonium salt easily to be acted on by organic matter and is failed.Therefore, disinfection effect cannot
It is satisfactory.
Invention content
For the above-mentioned prior art the problem of, the present invention provide a kind of comprehensively killing, stability good disinfectant
And preparation method thereof.
To achieve the above object, the present invention provides the following technical solutions：
A kind of disinfectant, including compound glutaraldehyde solution and foaming agent, the body of the compound glutaraldehyde solution and foaming agent
Product is than being 5:1, the compound glutaraldehyde solution includes：It is glutaraldehyde, benzalkonium chloride, double-chain quaternary ammonium salt one, double-chain quaternary ammonium salt two, non-
Ionic surface active agent one and nonionic surfactant two, the double-chain quaternary ammonium salt one are different objects from double-chain quaternary ammonium salt two
Matter, the nonionic surfactant one are different substances from nonionic surfactant two.
Further, according to mass fraction, the compound glutaraldehyde solution each component dosage is：Glutaraldehyde 15%-16%, benzene
Prick oronain 7%-8%, one 5%-6% of double-chain quaternary ammonium salt, two 4%-5% of double-chain quaternary ammonium salt, one 8%- of nonionic surfactant
9% and two 2%-4% of nonionic surfactant, surplus be purified water.
Further, the compound glutaraldehyde solution further includes allicin mother liquor, mass fraction 10%-12%.
Further, according to mass fraction, the compound glutaraldehyde solution each component dosage is：Glutaraldehyde 15.6%, benzene are pricked
Oronain 7.4%, double-chain quaternary ammonium salt one 5.5%, double-chain quaternary ammonium salt 2 4.6%, nonionic surfactant one 8.5%, nonionic
Surfactant 2 3% and allicin mother liquor 11%, surplus are purified water.
Further, the double-chain quaternary ammonium salt one is double decyl dimethyl hydroxyethyl ammonium chlorides, and the double-chain quaternary ammonium salt two is double
Alkyl dimethyl ammonium chloride.
Further, the carbon atom number of the alkyl in the Dialkyl dimethyl ammonium chloride is 8-10.
Further, the nonionic surfactant one is fatty alcohol Ethoxylate, the nonionic surfactant
Two be alkyl phenol polyoxyethylene ether.
Further, the foaming agent includes the gemini quaternary ammonium salt of Deciquam and polyoxyethylene ether diacetic acid ester group.
Further, the volume ratio of the gemini quaternary ammonium salt of the Deciquam and polyoxyethylene ether diacetic acid ester group is 2.8:1-
2.1:1。
In addition, preparing the method such as above-mentioned disinfectant the present invention also provides a kind of, include the following steps：
(1) each component of compound glutaraldehyde solution is mixed, obtains compound glutaraldehyde solution；By Deciquam and polyoxy second
The gemini quaternary ammonium salt of alkene ether diacetic acid ester group mixes, and obtains foaming agent；
(2) by compound glutaraldehyde solution and foaming agent according to volume ratio 5:1 mixing adjusts pH value to 3.0-4.0 to get institute
State disinfectant.
Beneficial effects of the present invention are as follows：
1, glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of nonionic surfactants are used cooperatively by the present invention, play association
Same-action, effect mutually enhance, and sterilization is comprehensive, has good bactericidal effect to bacterium, virus, mycoplasma, gemma etc.；
2, glutaraldehyde and a variety of cationic surfactants and nonionic surfactant are used cooperatively by the present invention, are made
Compound glutaraldehyde solution, compensate for be used alone glutaraldehyde sterilizing ability under acid-base condition it is weak, the disadvantage of stability difference；It makes up
Quaternary cationic surfactant is used alone and single, double chain quaternary ammonium salt be used cooperatively it is invalid to mycoplasma, gemma
Defect；Glutaraldehyde can be also made up simultaneously, and the defect for being acted on and being failed by organic matter is used in combination with double-chain quaternary ammonium salt；Glutaraldehyde
Solution dissolves in water and other multi-solvents, oozes under the action of cationic surfactant, nonionic surfactant
Enter and acted in crack, crackle, iron rust, the feather of chicken and various organic pollutions, and passes through Brownian movement and electrostatic attraction
Actively various pathogen are killed rapidly in trapping；
3, compound glutaraldehyde solution and foaming agent are used cooperatively by the present invention, and foaming agent is by Deciquam and polyoxyethylene ether
The gemini quaternary ammonium salt compounding of diacetic acid ester group is made, and improves glutaraldehyde well and coordinates with single-stranded quaternary ammonium salt, double-chain quaternary ammonium salt
Benzalkonium chloride low temperature has the shortcomings that crystallization is precipitated in use, greatly improves the Disinfection Effect and stability of disinfectant, also changes
It has been apt to cultivate the defect that field device is easily sterilized agent corrosion；
4, the allicin mother liquor bioactivity that the present invention uses is high, wide sterilization spectrum, adverse reaction very little, with glutaraldehyde, season
Ammonium salt class and nonionic surfactant fit applications, greatly enhance bactericidal effect, can kill pathogenic microorganism completely, and
And to metal class, plastic products, the corrosion-free effect of rubber product, efficacy time is long, environmental protection, belongs to safe efficient, green new
Type foamaseptic；
5, the addition of foaming agent makes the visual enhancing of disinfection, avoids disinfection blind area, be significantly reduced the wave of disinfectant
Take, reduces the liquid soakage of operating personnel, disinfection is evenly thorough, while enhancing the satisfaction of operating personnel；
6, compound glutaraldehyde solution and foaming agent are 5 according to volume ratio:1 uses, and foaming effect is best, can be remarkably reinforced
The bactericidal effect of compound glutaraldehyde solution；
7, the addition of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, make glutaraldehyde, two kinds of double-chain quaternary ammonium salt sun from
Sub- surfactant and two kinds of nonionic surfactants preferably play synergistic effect, and sterilization, dirt-removing power are stronger；And polyoxy
The gemini quaternary ammonium salt of vinethene diacetic acid ester group has higher foaming capacity and foam stabilizing ability and Deciquam fit applications pole
Big improves foaming effect, and visuality is stronger；
8, disinfectant of the invention also has a variety of effects such as deodorization, cleaning, algae removal.
Specific implementation mode
In order to make those skilled in the art more fully understand technical scheme of the present invention, below to technical scheme of the present invention into
Clear, the complete description of row, based on the embodiment in the application, those of ordinary skill in the art are not making creative work
Under the premise of other similar embodiments for being obtained, shall fall within the protection scope of the present application.
Embodiment one：
A kind of disinfectant, including compound glutaraldehyde solution and foaming agent, the body of the compound glutaraldehyde solution and foaming agent
Product is than being 5:1, at this point, foaming effect is best, the bactericidal effect of compound glutaraldehyde solution, the compound glutaraldehyde can be remarkably reinforced
Solution includes：
Glutaraldehyde, two kinds of cationic surfactants and two kinds of nonionic surfactants are used cooperatively by the present invention, system
At compound glutaraldehyde solution, weak, the disadvantage of stability difference that is used alone glutaraldehyde sterilizing ability under acid-base condition is compensated for；More
Quaternary cationic surfactant exclusive use and single, double chain quaternary ammonium salt have been mended with the use of invalid to mycoplasma, gemma
Defect；Glutaraldehyde can be also made up simultaneously, and the defect for being acted on and being failed by organic matter is used in combination with double-chain quaternary ammonium salt；Penta 2
Aldehyde solution dissolves in water and other multi-solvents under the action of cationic surfactant, nonionic surfactant,
It penetrates into crack, crackle, iron rust, the feather of chicken and various organic pollutions and is acted on, and drawn by Brownian movement and electrostatic
Advocate to move to trap and kills various pathogen rapidly.
Allicin mother liquor bioactivity is high, wide sterilization spectrum, adverse reaction very little, with glutaraldehyde, quaternary ammonium salt and nonionic
Surfactant fit applications, greatly enhance bactericidal effect, can kill pathogenic microorganism completely, and to metal class, modeling
The corrosion-free effect of material products, rubber product, efficacy time is long, environmentally friendly, belongs to safe efficient, green novel foam disinfectant.
Wherein, DEQ is double decyl dimethyl hydroxyethyl ammonium chlorides, and double 8-10 are one kind in Dialkyl dimethyl ammonium chloride,
One kind in AEO-9 fatty alcohol Ethoxylates, TX-10 are nonylphenol polyoxyethylene ether, are in alkyl phenol polyoxyethylene ether
It is a kind of.Glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of nonionic surfactants are used cooperatively by the present invention, are played collaboration and are made
With effect mutually enhances, and sterilization is comprehensive.
Foaming agent includes：The gemini quaternary ammonium salt of 70% deciquam solution and polyoxyethylene ether diacetic acid ester group, volume ratio
It is 4:1, i.e. the volume ratio of the gemini quaternary ammonium salt of deciquam solution and polyoxyethylene ether diacetic acid ester group is 2.8:1.Foaming agent
Addition, make the visual enhancing of disinfection, avoid disinfection blind area, be significantly reduced the waste of disinfectant, reduce operating personnel's
Liquid soakage, disinfection is evenly thorough, while enhancing the satisfaction of operating personnel.
The preparation method of the disinfectant, includes the following steps：
(1) each component of compound glutaraldehyde solution is mixed, obtains compound glutaraldehyde solution；By 70% deciquam solution
It is mixed with the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, foaming agent is made；
(2) by compound glutaraldehyde solution and foaming agent according to volume ratio 5:1 mixing adjusts pH value and disappears to 3.0 to get described
Toxic agent.Compound glutaraldehyde solution is used cooperatively by the present invention with foaming agent, and foaming agent is by Deciquam and the double second of polyoxyethylene ether
The gemini quaternary ammonium salt compounding of perester radical is made, and improves glutaraldehyde well and is used cooperatively with single-stranded quaternary ammonium salt, double-chain quaternary ammonium salt
Middle benzalkonium chloride low temperature has the shortcomings that crystallization is precipitated, and greatly improves the Disinfection Effect and stability of disinfectant, also improves
Cultivation field device is easily sterilized the defect of agent corrosion.
The mixing of compound glutaraldehyde solution each component includes the following steps：
(1) glutaraldehyde, allicin mother liquor, AEO-9 and TX-10 are mixed, it is made to be uniformly mixed and be completely dissolved, it is quiet
It sets, obtains mixed liquor one；
(2) benzalkonium chloride, DEQ and double 8-10 are added into mixed liquor one, stirring obtains mixed liquor two.
(3) purified water is added into mixed liquor two to 1L, obtains compound glutaraldehyde solution.
The addition of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group makes two kinds of double-chain quaternary ammonium salt cation surface activatings
Agent and two kinds of nonionic surfactants preferably play synergistic effect, and sterilization, dirt-removing power are stronger；And the double second of polyoxyethylene ether
There is the gemini quaternary ammonium salt of perester radical higher foaming capacity and foam stabilizing ability and Deciquam fit applications to greatly improve
Foaming effect, it is visual stronger.
The disinfectant of the present invention also has a variety of effects such as deodorization, cleaning, algae removal.
Embodiment two：
A kind of disinfectant, including compound glutaraldehyde solution and foaming agent, the body of the compound glutaraldehyde solution and foaming agent
Product is than being 5:1, at this point, foaming effect is best, the bactericidal effect of compound glutaraldehyde solution, the compound glutaraldehyde can be remarkably reinforced
Solution includes：
Glutaraldehyde, two kinds of cationic surfactants and two kinds of nonionic surfactants are used cooperatively by the present invention, system
At compound glutaraldehyde solution, weak, the disadvantage of stability difference that is used alone glutaraldehyde sterilizing ability under acid-base condition is compensated for；More
Quaternary cationic surfactant exclusive use and single, double chain quaternary ammonium salt have been mended with the use of invalid to mycoplasma, gemma
Defect；Glutaraldehyde can be also made up simultaneously, and the defect for being acted on and being failed by organic matter is used in combination with double-chain quaternary ammonium salt；Penta 2
Aldehyde solution dissolves in water and other multi-solvents under the action of cationic surfactant, nonionic surfactant,
It penetrates into crack, crackle, iron rust, the feather of chicken and various organic pollutions and is acted on, and drawn by Brownian movement and electrostatic
Advocate to move to trap and kills various pathogen rapidly.
Allicin mother liquor bioactivity is high, wide sterilization spectrum, adverse reaction very little, with glutaraldehyde, quaternary ammonium salt and nonionic
Surfactant fit applications, greatly enhance bactericidal effect, can kill pathogenic microorganism completely, and to metal class, modeling
The corrosion-free effect of material products, rubber product, efficacy time is long, environmentally friendly, belongs to safe efficient, green novel foam disinfectant.
Wherein, DEQ is double decyl dimethyl hydroxyethyl ammonium chlorides, and double 8-10 are one kind in Dialkyl dimethyl ammonium chloride,
AEO-9 is one kind in fatty alcohol Ethoxylate, and TX-10 is nonylphenol polyoxyethylene ether, is in alkyl phenol polyoxyethylene ether
One kind.Glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of nonionic surfactants are used cooperatively by the present invention, are played collaboration and are made
With effect mutually enhances, and sterilization is comprehensive.
Foaming agent includes：The gemini quaternary ammonium salt of 70% deciquam solution and polyoxyethylene ether diacetic acid ester group, volume ratio
It is 4:1, i.e. the volume ratio of the gemini quaternary ammonium salt of deciquam solution and polyoxyethylene ether diacetic acid ester group is 2.8:1.Foaming agent
Addition, make the visual enhancing of disinfection, avoid disinfection blind area, be significantly reduced the waste of disinfectant, reduce operating personnel's
Liquid soakage, disinfection is evenly thorough, while enhancing the satisfaction of operating personnel.
The preparation method of the disinfectant, including：
(1) each component of compound glutaraldehyde solution is mixed, obtains compound glutaraldehyde solution；By 70% deciquam solution
It is mixed with the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, foaming agent is made；
(2) by compound glutaraldehyde solution and foaming agent according to volume ratio 5:1 mixing adjusts pH value and disappears to 3.5 to get described
Toxic agent.Compound glutaraldehyde solution is used cooperatively by the present invention with foaming agent, and foaming agent is by Deciquam and the double second of polyoxyethylene ether
The gemini quaternary ammonium salt compounding of perester radical is made, and improves glutaraldehyde well and is used cooperatively with single-stranded quaternary ammonium salt, double-chain quaternary ammonium salt
Middle benzalkonium chloride low temperature has the shortcomings that crystallization is precipitated, and greatly improves the Disinfection Effect and stability of disinfectant, also improves
Cultivation field device is easily sterilized the defect of agent corrosion.
The mixing of compound glutaraldehyde solution each component includes the following steps：
(1) glutaraldehyde, allicin mother liquor, AEO-9 and TX-10 are mixed, it is made to be uniformly mixed and be completely dissolved, it is quiet
It sets, obtains mixed liquor one；
(2) benzalkonium chloride, DEQ and double 8-10 are added into mixed liquor one, stirring obtains mixed liquor two.
(3) purified water is added into mixed liquor two to 1L, obtains compound glutaraldehyde solution.
The addition of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group makes two kinds of double-chain quaternary ammonium salt cation surface activatings
Agent and two kinds of nonionic surfactants preferably play synergistic effect, and sterilization, dirt-removing power are stronger；And the double second of polyoxyethylene ether
There is the gemini quaternary ammonium salt of perester radical higher foaming capacity and foam stabilizing ability and Deciquam fit applications to greatly improve
Foaming effect, it is visual stronger.
The disinfectant of the present invention also has a variety of effects such as deodorization, cleaning, algae removal.
Embodiment three：
A kind of disinfectant, including compound glutaraldehyde solution and foaming agent, the body of the compound glutaraldehyde solution and foaming agent
Product is than being 5:1, at this point, foaming effect is best, the bactericidal effect of compound glutaraldehyde solution, the compound glutaraldehyde can be remarkably reinforced
Solution includes：
Glutaraldehyde, two kinds of cationic surfactants and two kinds of nonionic surfactants are used cooperatively by the present invention, system
At compound glutaraldehyde solution, compensates for and be used alone that glutaraldehyde disinfection sterilizing ability under acid-base condition is weak, and stability difference lacks
Point；It compensates for quaternary cationic surfactant exclusive use and single, double chain quaternary ammonium salt is used cooperatively to mycoplasma, gemma
Invalid defect；Glutaraldehyde can be also made up simultaneously, and the defect for being acted on and being failed by organic matter is used in combination with double-chain quaternary ammonium salt；
Glutaraldehyde solution dissolves in water and other is a variety of under the action of cationic surfactant, nonionic surfactant
Solvent penetrates into crack, crackle, iron rust, is acted in the feather of chicken and various organic pollutions, and passes through Brownian movement and quiet
Actively various pathogen are killed rapidly in trapping to electric attraction.
Allicin mother liquor bioactivity is high, wide sterilization spectrum, adverse reaction very little, with glutaraldehyde, quaternary ammonium salt and nonionic
Surfactant fit applications, greatly enhance bactericidal effect, can kill pathogenic microorganism completely, and to metal class, modeling
The corrosion-free effect of material products, rubber product, efficacy time is long, environmentally friendly, belongs to safe efficient, green novel foam disinfectant.
Wherein, DEQ is double decyl dimethyl hydroxyethyl ammonium chlorides, and double 8-10 are one kind in Dialkyl dimethyl ammonium chloride,
AEO-9 is one kind in fatty alcohol Ethoxylate, and TX-10 is nonylphenol polyoxyethylene ether, is in alkyl phenol polyoxyethylene ether
One kind.Glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of nonionic surfactants are used cooperatively by the present invention, are played collaboration and are made
With effect mutually enhances, and sterilization is comprehensive.
Foaming agent includes：The gemini quaternary ammonium salt of 70% deciquam solution and polyoxyethylene ether diacetic acid ester group, volume ratio
It is 3.5:1, i.e. the volume ratio of the gemini quaternary ammonium salt of deciquam solution and polyoxyethylene ether diacetic acid ester group is 2.45:1.Foaming
The addition of agent makes the visual enhancing of disinfection, avoids disinfection blind area, be significantly reduced the waste of disinfectant, reduce operating personnel
Liquid soakage, disinfection is evenly thorough, while enhancing the satisfaction of operating personnel.
The preparation method of the disinfectant, including：
(1) each component of compound glutaraldehyde solution is mixed, obtains compound glutaraldehyde solution；By 70% deciquam solution
It is mixed with the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, foaming agent is made；
(2) by compound glutaraldehyde solution and foaming agent according to volume ratio 5:1 mixing adjusts pH value and disappears to 3.2 to get described
Toxic agent.Compound glutaraldehyde solution is used cooperatively by the present invention with foaming agent, and foaming agent is by Deciquam and the double second of polyoxyethylene ether
The gemini quaternary ammonium salt compounding of perester radical is made, and improves glutaraldehyde well and is used cooperatively with single-stranded quaternary ammonium salt, double-chain quaternary ammonium salt
Middle benzalkonium chloride low temperature has the shortcomings that crystallization is precipitated, and greatly improves the Disinfection Effect and stability of disinfectant, also improves
Cultivation field device is easily sterilized the defect of agent corrosion.
The mixing of compound glutaraldehyde solution each component includes the following steps：
(1) glutaraldehyde, allicin mother liquor, AEO-9 and TX-10 are mixed, it is made to be uniformly mixed and be completely dissolved, it is quiet
It sets, obtains mixed liquor one；
(2) benzalkonium chloride, DEQ and double 8-10 are added into mixed liquor one, stirring obtains mixed liquor two.
(3) purified water is added into mixed liquor two to 1L, obtains compound glutaraldehyde solution.
The addition of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group makes two kinds of double-chain quaternary ammonium salt cation surface activatings
Agent and two kinds of nonionic surfactants preferably play synergistic effect, and sterilization, dirt-removing power are stronger；And the double second of polyoxyethylene ether
There is the gemini quaternary ammonium salt of perester radical higher foaming capacity and foam stabilizing ability and Deciquam fit applications to greatly improve
Foaming effect, it is visual stronger.
The disinfectant of the present invention also has a variety of effects such as deodorization, cleaning, algae removal.
Example IV：
A kind of disinfectant, including compound glutaraldehyde solution and foaming agent, the body of the compound glutaraldehyde solution and foaming agent
Product is than being 5:1, at this point, foaming effect is best, the bactericidal effect of compound glutaraldehyde solution, the compound glutaraldehyde can be remarkably reinforced
Solution includes：
Glutaraldehyde, two kinds of cationic surfactants and two kinds of nonionic surfactants are used cooperatively by the present invention, system
At compound glutaraldehyde solution, compensates for and be used alone that glutaraldehyde disinfection sterilizing ability under acid-base condition is weak, and stability difference lacks
Point；It compensates for quaternary cationic surfactant exclusive use and single, double chain quaternary ammonium salt is used cooperatively to mycoplasma, gemma
Invalid defect；Glutaraldehyde can be also made up simultaneously, and the defect for being acted on and being failed by organic matter is used in combination with double-chain quaternary ammonium salt；
Glutaraldehyde solution dissolves in water and other is a variety of under the action of cationic surfactant, nonionic surfactant
Solvent penetrates into crack, crackle, iron rust, is acted in the feather of chicken and various organic pollutions, and passes through Brownian movement and quiet
Actively various pathogen are killed rapidly in trapping to electric attraction.
Allicin mother liquor bioactivity is high, wide sterilization spectrum, adverse reaction very little, with glutaraldehyde, quaternary ammonium salt and nonionic
Surfactant fit applications, greatly enhance bactericidal effect, can kill pathogenic microorganism completely, and to metal class, modeling
The corrosion-free effect of material products, rubber product, efficacy time is long, environmentally friendly, belongs to safe efficient, green novel foam disinfectant.
Wherein, DEQ is double decyl dimethyl hydroxyethyl ammonium chlorides, and double 8-10 are one kind in Dialkyl dimethyl ammonium chloride,
AEO-9 is one kind in fatty alcohol Ethoxylate, and TX-10 is nonylphenol polyoxyethylene ether, is in alkyl phenol polyoxyethylene ether
One kind.Glutaraldehyde, two kinds of double-chain quaternary ammonium salts and two kinds of nonionic surfactants are used cooperatively by the present invention, are played collaboration and are made
With effect mutually enhances, and sterilization is comprehensive.
Foaming agent includes：The gemini quaternary ammonium salt of 70% deciquam solution and polyoxyethylene ether diacetic acid ester group, volume ratio
It is 3:1, i.e. the volume ratio of the gemini quaternary ammonium salt of deciquam solution and polyoxyethylene ether diacetic acid ester group is 2.1:1.Foaming agent
Addition, make the visual enhancing of disinfection, avoid disinfection blind area, be significantly reduced the waste of disinfectant, reduce operating personnel's
Liquid soakage, disinfection is evenly thorough, while enhancing the satisfaction of operating personnel.
The preparation method of the disinfectant, including：
(1) each component of compound glutaraldehyde solution is mixed, obtains compound glutaraldehyde solution；By 70% deciquam solution
It is mixed with the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group, foaming agent is made；
(2) by compound glutaraldehyde solution and foaming agent according to volume ratio 5:1 mixing adjusts pH value and disappears to 3.0 to get described
Toxic agent.Compound glutaraldehyde solution is used cooperatively by the present invention with foaming agent, and foaming agent is by Deciquam and the double second of polyoxyethylene ether
The gemini quaternary ammonium salt compounding of perester radical is made, and improves glutaraldehyde well and is used cooperatively with single-stranded quaternary ammonium salt, double-chain quaternary ammonium salt
Middle benzalkonium chloride low temperature has the shortcomings that crystallization is precipitated, and greatly improves the Disinfection Effect and stability of disinfectant, also improves
Cultivation field device is easily sterilized the defect of agent corrosion.
The mixing of compound glutaraldehyde solution each component includes the following steps：
(1) glutaraldehyde, allicin mother liquor, AEO-9 and TX-10 are mixed, it is made to be uniformly mixed and be completely dissolved, it is quiet
It sets, obtains mixed liquor one；
(2) benzalkonium chloride, DEQ and double 8-10 are added into mixed liquor one, stirring obtains mixed liquor two.
(3) purified water is added into mixed liquor two to 1L, obtains compound glutaraldehyde solution.
The addition of the gemini quaternary ammonium salt of polyoxyethylene ether diacetic acid ester group makes two kinds of double-chain quaternary ammonium salt cation surface activatings
Agent and two kinds of nonionic surfactants preferably play synergistic effect, and sterilization, dirt-removing power are stronger；And the double second of polyoxyethylene ether
There is the gemini quaternary ammonium salt of perester radical higher foaming capacity and foam stabilizing ability and Deciquam fit applications to greatly improve
Foaming effect, it is visual stronger.
The disinfectant of the present invention also has a variety of effects such as deodorization, cleaning, algae removal.
Contrast test one：
The preparation of bacteria suspension：Escherichia coli (ATCC8099), staphylococcus aureus (ATCC6538), Candida albicans
(ATCC10231), bacillus subtilis (ATCC6633), mycoplasma hyorhinis (ATCC17981) fresh slant culture, with dilution
Liquid (tryptone normal saline solution) 5mL is washed down and is configured to bacteria suspension.Bacteria suspension and 3% bovine serum albumin are made when experiment
Half-and-half dilute.
By DEQ, double 8-10, AEO-9 purifying water dissolution, TX-10 is diluted with purified water, and it is 40mg/L's to obtain concentration
DEQ, double 8-10, AEO-9 and solution individually or after being combined with each other obtain 13 groups of experimental groups, penta are added into each group of experimental group
Dialdehyde solution, addition are the 15% of overall solution volume, and 13 groups of experimental groups are then respectively acting on staphylococcus aureus, big
Enterobacteria, Candida albicans, bacillus subtilis and mycoplasma hyorhinis bacteria suspension 20min, sample and poured into and connect with culture medium
Kind, it is cultivated under the conditions of 37 DEG C, 48h is cultivated for staphylococcus aureus, Escherichia coli, for Candida albicans, withered grass bud
Spore bacillus and mycoplasma hyorhinis culture 72h.
Control group：Disinfectant solution is replaced with dilution (tryptone normal saline solution), by above-mentioned same step
It is tested.Acquired results represent the original concentration of bacterium solution, using it as the initial concentration for calculating sterilization logarithm.As a result such as 1 institute of table
Show.
Calculate the viable bacteria concentration (cfumL of each group-1), and it is scaled logarithm, killing logarithm is calculated as follows.
Kill logarithm-experimental group viable bacteria concentration logarithm of logarithm (KL)=control group viable bacteria concentration.
KL values are the logarithm of microorganism reduction before and after disinfection when micro organism quantity is expressed in logarithmic, KL value generations
The table power of disinfectant sterilizing ability.KL values are bigger, and the sterilizing ability of disinfectant is stronger, conversely, weaker.
Table 1：Use the KL values of different surfaces activating agent
This experimental data is provided by Shandong Sinder Technology Co., Ltd. laboratory
As can be seen from Table 1, good bactericidal effect cannot all be reached by any of which surfactant being used alone,
And after being applied in combination for wherein arbitrary two or three, the sterilizing ability of composition improves, by glutaraldehyde, DEQ, double 8-10,
After AEO-9 and TX-10 combinations, bactericidal effect significantly improves, and four play apparent synergistic function with glutaraldehyde, sterilize
Ability significantly improves.
Contrast test two：
Test method：
Using artificial contaminated bacteria samples metope as sterilization objects, bacterium used is Escherichia coli 8099.When microbiological contamination, the portion that article is more flat is selected
Position is stained with bacteria suspension with sterile cotton swab in the space of dimension board center and uniformly smears 3 blocks for being tested surface (area is respectively
25cm2).The preparation method of bacteria suspension is tested with contrast test one after spontaneously drying.
Each group disinfectant is sparged body surface by a certain concentration dilution to carry out disinfection.After disinfection, by sterile cotton swab in
It is bedewed in neutralizer containing 5ml (neutralizer is 500mlPBS+2.5g glycine+2.5g lecithin+2.5g Tween 80s) test tube, respectively
Swabing sampling is carried out to 3 disinfection blocks, it is vertical and horizontal each 8 times round-trip per block.After sampling, cotton swab is sampled in a manner of sterile working
End is cut in former neutralizer test tube, rapping 200 times, acts on 10min.Make appropriate dilution with neutralizer when necessary.By every part of sample
1.0ml is drawn, plate is inoculated with agar tilt-pour process, each sample is inoculated with 1 plate, puts in 37 DEG C of insulating boxs and cultivate 48h, observes
Final result.
The gemini quaternary ammonium salt of 70% deciquam solution and polyoxyethylene ether diacetic acid ester group is with 4:1 volume ratio mixes conduct
Foaming agent is tested, and control group is divided into 5 groups：Peace kills spraying group (1:200 times dilution), compound glutaraldehyde solution spraying group
(1:200 times dilution), compound glutaraldehyde solution+Deciquam foam group (1:100 times of dilutions, 5L compound glutaraldehydes+70% last of the ten Heavenly stems first
Bromine ammonium salt solution 1L), the gemini quaternary ammonium salt foam group (1 of compound glutaraldehyde solution+polyoxyethylene ether diacetic acid ester group:100 times dilute
Release, the gemini quaternary ammonium salt 1kg of 5L compound glutaraldehydes+polyoxyethylene ether diacetic acid ester group), foaming agent group (1:350 times of dilutions,
The gemini quaternary ammonium salt 1kg of 70% Deciquam 4L+ ethylene oxide ether diacetic acid ester groups).Each control group disinfectant institute of this contrast test
Compound glutaraldehyde solution is identical as each component of two compound glutaraldehyde solution of the embodiment of the present invention and amounts of components.Experimental group
For the embodiment of the present invention one to four, and compound glutaraldehyde solution+foaming agent (1:200 times of dilutions), each group sterilizing rate result is such as
The following table 2.
Table 2：The bactericidal effect of different disinfectants
This experimental data is provided by Shandong Sinder Technology Co., Ltd. laboratory
As can be seen from Table 2, almost 100% sterilization can be reached by removing (compound glutaraldehyde+foaming agent foam group) of the invention
Outside rate, remaining each group cannot kill the Escherichia coli of this experiment completely.Also, it is also that glutaraldehyde and quaternary ammonium salt are multiple that peace, which is killed,
Fungicide made of matching, sterilizing rate are only 94.7%, and the bactericidal effect of the compound glutaraldehyde solution spraying group of the present invention is
96.7%, hence it is evident that killed higher than peace.The gemini quaternary ammonium salt of Deciquam or polyoxyethylene ether diacetic acid ester group is individually selected to carry out
When foaming, it is below sterilizing rate of the two combination as foaming agent, therefore, compounding foaming agent of the invention and compound glutaraldehyde are molten
Liquid is used cooperatively, and significantly enhances the disinfection effect of disinfectant of the present invention, can be played to bacterium and almost 100% be killed.Separately
Outside, the bactericidal effect of the embodiment of the present invention one to four is superior to existing disinfectant peace and kills, illustrate the bactericidal effect of the present invention with
The prior art is compared, and is improved really.Also, for general disinfectant on the market, sterilizing rate reaches 98% or more
It is very difficult, and the sterilizing rate of the embodiment of the present invention one to four is 98% or more, it is almost reachable to the sterilizing rate of bacterium
100%.
By contrast test one as it can be seen that the disinfectant of the present invention is to staphylococcus aureus, Candida albicans, mycoplasma, bud
Spore etc. has preferable bactericidal effect, and sterilization mechanism is with to the same or like of Escherichia coli, and therefore, this contrast test is killed
Bacterium effect can represent bactericidal effect of the present invention to other bacteriums and virus.
Experiment three：
The experiment of disinfectant stability test with reference to Chinese veterinary pharmacopoeia one annex of version in 2010, mainly investigate its high temperature,
Appearance character, acid-base value, clarity of solution and color, clarity under the conditions of illumination and deepfreeze, in relation to substance and content.
To peace kill the disinfectant of disinfectant and the embodiment of the present invention two 60 DEG C, 4500LX ± 500LX illuminance, low temperature
It is placed under refrigerated condition, as a result see the table below 3 and table 4 compared with 0 day data in the 5th, 10 day sample detection indices.
3 disinfectant stability test result of the present invention of table
This experimental data is provided by Shandong Sinder Technology Co., Ltd. laboratory
The peace of table 4 kills stability test result
This experimental data is provided by Shandong Sinder Technology Co., Ltd. laboratory
By 3 test result of table it is found that the disinfectant of the embodiment of the present invention two is into after crossing high temperature, low temperature and photo-irradiation treatment,
The measurement result of indices meets regulation, and active ingredient glutaraldehyde and allicin are largely all stabilized, pH value model
It is 3.0~4.0 to enclose still, and appearance and clarity have no significant change, and illustrates that the disinfectant stability of the present invention is good.
By 4 test result of table it is found that peace kills placement 10 days, after high temperature, low temperature and illumination, active ingredient glutaraldehyde
It is a large amount of to decompose, there is color change, precipitation and muddiness, illustrates that the stability that peace is killed is poor, high temperature, low temperature and illumination can influence
Its stability leads to the reduction of its sterilizing rate.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (4)
1. a kind of disinfectant, which is characterized in that including compound glutaraldehyde solution and foaming agent, the compound glutaraldehyde solution and hair
The volume ratio of infusion is 5:1, according to mass fraction, the compound glutaraldehyde solution each component dosage is：Glutaraldehyde 15%-
16%, benzalkonium chloride 7%-8%, one 5%-6% of double-chain quaternary ammonium salt, two 4%-5% of double-chain quaternary ammonium salt, nonionic surfactant
One 8%-9%, two 2%-4% of nonionic surfactant and allicin mother liquor 10%-12%, surplus are purified water, described double
Chain quaternary ammonium salt one is different substances, the nonionic surfactant one and nonionic surfactant from double-chain quaternary ammonium salt two
Two be different substances；
The double-chain quaternary ammonium salt one is double decyl dimethyl hydroxyethyl ammonium chlorides, and the double-chain quaternary ammonium salt two is double alkyl dimethyl chlorine
Change ammonium, the nonionic surfactant one is fatty alcohol Ethoxylate, and the nonionic surfactant two is alkyl phenol
Polyoxyethylene ether；
The foaming agent includes the gemini quaternary ammonium salt of Deciquam and polyoxyethylene ether diacetic acid ester group, the Deciquam and poly-
The volume ratio of the gemini quaternary ammonium salt of ethylene oxide ether diacetic acid ester group is 2.8:1-2.1:1.
2. disinfectant according to claim 1, which is characterized in that according to mass fraction, the compound glutaraldehyde solution is each
Amounts of components is：It is glutaraldehyde 15.6%, benzalkonium chloride 7.4%, double-chain quaternary ammonium salt one 5.5%, double-chain quaternary ammonium salt 2 4.6%, non-
Ionic surface active agent one 8.5%, nonionic surfactant 2 3% and allicin mother liquor 11%, surplus are purified water.
3. disinfectant according to claim 2, which is characterized in that the carbon of the alkyl in the Dialkyl dimethyl ammonium chloride
Atom number is 8-10.
4. a kind of method preparing disinfectant as described in any one of claims 1-3, which is characterized in that include the following steps：
(1) each component of compound glutaraldehyde solution is mixed, obtains compound glutaraldehyde solution；By Deciquam and polyoxyethylene ether
The gemini quaternary ammonium salt of diacetic acid ester group mixes, and obtains foaming agent；
(2) by compound glutaraldehyde solution and foaming agent according to volume ratio 5:1 mixing adjusts pH value and disappears to 3.0-4.0 to get described
Toxic agent.
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