CN110583686A - Ultralow temperature resistant storage disinfection and disinsection compound preparation - Google Patents
Ultralow temperature resistant storage disinfection and disinsection compound preparation Download PDFInfo
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- CN110583686A CN110583686A CN201910798193.2A CN201910798193A CN110583686A CN 110583686 A CN110583686 A CN 110583686A CN 201910798193 A CN201910798193 A CN 201910798193A CN 110583686 A CN110583686 A CN 110583686A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
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- Pest Control & Pesticides (AREA)
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Abstract
The invention discloses an ultralow temperature storage-resistant disinfection and disinsection compound preparation which comprises the following components: (A) deltamethrin, bioallethrin or betathrin, synergistic ether, tributyl phosphate, emulsifier, ethanol and glycol; (B) triclosan, sodium bicarbonate or disodium hydrogen phosphate, sodium nitrite. The invention is prepared by adopting environment-friendly raw materials, can be degraded in the environment, has short half-life period and is easy to be degraded into low-toxicity and nontoxic substances. The preparation of the invention can be preserved for a long time at 40 ℃ below zero, and is suitable for plateau alpine regions. The preparation has good disinfection effect, has good killing effect on Escherichia coli (Escherichia coli) CMCC (B)44102), staphylococcus aureus (CMCC (B)26003), pseudomonas aeruginosa (CMCC (B)10104), Candida albicans (CMCC (F)98001) and Aspergillus niger (CMCC (F)98003), and also has good killing effect on Culex pipiens pallens and Aedes albopictus.
Description
Technical Field
The invention relates to a disinfection and disinsection compound preparation, in particular to an ultralow temperature storage-resistant disinfection and disinsection compound preparation.
Background
Insecticides are a class of chemical agents used to knock down or kill vector insects, thereby reducing blood-sucking disturbance and blocking the transmission of insect-borne infectious diseases. Pyrethroid insecticides become one of the high-efficiency insecticides widely applied to sanitary insecticide products by the advantages of high efficiency, low toxicity, quick knockdown, high killing efficiency, small environmental pollution and the like, and have been widely popularized and applied in various fields in the past decades. Because the insecticide is widely used in the agricultural and sanitary fields for a long time, domestic common vector insects have different degrees of resistance and cross resistance to organophosphorus and pyrethroid insecticides and the like, alternative application, alternate application and compound application are inevitable choices for improving pesticide effect, reducing cost, delaying development of resistance and prolonging service life of the existing insecticide.
Disinfectants are agents used to eliminate pathogenic microorganisms from various surfaces or media to the point of being inadequately harmful. Therefore, the disinfectant and the pesticide both act on a transmission medium or a medium to cut off a transmission path and reduce the occurrence of diseases, in some special occasions such as garbage harmless treatment, animal carcass treatment in disaster rescue, and anti-biological warfare and anti-biological terrorist attack, emergency treatment of vector organisms and quick killing of pathogens are needed, both the two kinds of agents are needed to be used, and in order to reduce the consumption of manpower and material resources and improve the use efficiency of the agents, the two kinds of agents are considered to be compounded. In the past, researchers also compound the low-efficiency disinfectant and the insecticide, the insecticidal effect is good, but the disinfection effect is still to be improved.
In addition, although various vector insects and pathogenic microorganisms are difficult to reproduce due to environmental factors in the alpine region of the plateau, vector insects and pathogenic microorganisms suitable for living in the alpine region of the plateau often have strong vitality and are difficult to kill. And the conventional disinfection insecticide is only suitable for being used at normal temperature, is easy to solidify in plateau alpine regions and cannot be used.
Disclosure of Invention
The invention aims to provide an ultralow temperature storage-resistant disinfection and disinsection compound preparation.
The technical scheme of the invention is as follows:
the ultra-low temperature resistant storage disinfection insecticidal compound preparation comprises the following components:
(A) deltamethrin, bioallethrin or betathrin, synergistic ether, tributyl phosphate, emulsifier, ethanol and glycol;
(B) triclosan, sodium bicarbonate or disodium hydrogen phosphate, sodium nitrite.
Preferably, the weight ratio of each component is as follows:
preferably, the emulsifier comprises the following components in percentage by weight: the special phenethyl phenol formaldehyde resin polyoxyethylene ether accounts for 25 wt%; calcium dodecyl sulfonate accounting for 25 wt%; styryl phenyl polyoxyethylene ether accounting for 25 wt%; alkylphenol formaldehyde resin polyoxyethylene ether accounts for 25 wt%.
Deltamethrin, bioallethrin or betavalinate have the main effects of quickly killing or knocking down vector insects, deltamethrin has the knocking down effect on insects, but the killing effect is particularly outstanding, and bioallethrin or betavalinate has a very good knocking down effect on insects.
The synergistic ether is a synergist and is mainly used for overcoming the metabolic resistance of insects and effectively exerting the insecticidal effect of the insecticide.
Tributyl phosphate is used as a defoaming agent, and when the tributyl phosphate is used in a proper amount, the concentrated solution does not generate foam basically.
The emulsifier is a surfactant and consists of special phenethyl phenol formaldehyde resin polyoxyethylene ether, calcium dodecyl sulfonate, styryl phenyl polyoxyethylene ether and alkylphenol formaldehyde resin polyoxyethylene ether, the component is used for overcoming the problem that an original drug (oily substance) and water cannot be mixed, the hydrophilic ester group of the emulsifier is combined with the oily effective component deltamethrin, bioallethrin or betathrin, and the hydrophilic group at the other end is combined with water, so that the oily effective component can be uniformly dispersed in the water.
Ethanol has two purposes, namely, the dissolution of the original medicine is promoted, and the low-temperature storage is promoted. The ethylene glycol and ethanol together promote low temperature storage, reaching a minimum of-40 ℃.
Triclosan is a surfactant with a bactericidal effect, has a good killing and inhibiting effect on escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, candida albicans, aspergillus niger and the like, and sodium bicarbonate or disodium hydrogen phosphate is mainly used for buffering a solution system to reduce the denaturation of the insecticide caused by the oxidability of the disinfectant.
The sodium nitrite has the function of slowing down the corrosion of the disinfectant on the disinfected equipment. The components of the compound are an organic whole, and the functions of low-temperature storage, vector insect knockdown and pathogen killing are realized together.
The invention has the following beneficial effects:
1. the invention is prepared by adopting environment-friendly raw materials, can be degraded in the environment, has short half-life period and is easy to be degraded into low-toxicity and nontoxic substances.
2. The preparation of the invention can be preserved for a long time at 40 ℃ below zero, and is suitable for plateau alpine regions.
3. The preparation of the invention has good disinfection effect, and has good killing effect on culex pipiens pallens and aedes albopictus.
Detailed Description
For better understanding of the present invention, the technical solution of the present invention will be described in detail with specific examples, but the present invention is not limited thereto.
Examples 1 to 2:
the formulation of the ultra-low temperature storage-resistant disinfection and disinsection compound preparation is shown in the table 1.
Table 1: formulation tables for examples 1-2
Low temperature storage experiment:
two bottles of each of the formulations of example 1 and example 2, 10ml each, were placed in a freezer at a predetermined temperature (20 degrees below zero, 40 degrees below zero), and after 24 hours, they were taken out and the liquids of the two formulations were observed to be solidified.
The experimental results are as follows: the formulations of example 1 and example 2 did not set when stored at-20 ℃ for 24 hours.
The formulations of example 1 and example 2 did not set when stored at-40 ℃ for 24 hours.
And (3) detecting the disinfection effect:
1 test bacterial liquid:
escherichia coli (Escherichia coli) CMCC (B)44102
Staphylococcus aureus (Staphylococcus aureus) CMCC (B)26003
Pseudomonas aeruginosa (Pseudomonas aeruginosa) CMCC (B)10104
Candida albicans (Candida albicans) CMCC (F)98001
Aspergillus niger (Aspergillus niger) CMCC (F)98003
2, preparing a bacterial liquid:
respectively diluting the nutrient broth liquid culture of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa cultured at 35 deg.C for 18 hr to 10% with 0.9% sterile sodium chloride solution-5200ml of bacterial liquid containing about 50-100cfu/ml of bacteria is reserved.
Diluting Candida albicans liquid culture cultured at 35 deg.C for 18 hr to 10% with 0.9% sterile sodium chloride solution-5200ml of bacterial liquid containing about 50-100cfu/ml of bacteria is reserved.
Taking Aspergillus niger slant culture, diluting with 0.9% sterile sodium chloride solution to 10-5200ml of bacterial liquid containing about 50-100cfu/ml of bacteria is reserved.
3 test solution 0.9% sterile sodium chloride solution
4 nutrient medium nutrient agaricus medium, sodium rose sodium medium and nutrient broth medium, which are all commercial dry powder culture media.
Test method 5
(1) Bare hand sampling method
The 10 test persons were divided into two groups and tested with the test article and the reference article. The tester smears the contact finger surface of both hands, which were not sterilized with a disinfectant, on the surface of the medium of the sampling plate. Removing 5ml of venom from palm, and kneading with strong force until the liquid covers the whole surface of hand, and acting for 1 min. After the disinfectant on the hands is dried, the surfaces of the fingers contacted by the hands are smeared on the surface of the culture medium of the other sampling flat plate. And (4) inverting the sampling plate, culturing in a constant-temperature incubator at 35.0 ℃ for 48h, taking out and checking. The sampled media plates were also subjected to blank control experiments.
(2) Glovebacteria sampling method:
a bacterial liquid group: the experimenter wears sterile gloves, completely immerses hands in 200ml of bacteria solution, keeps the bacteria solution for 1min, lifts the hands out of the bacteria solution, uses a sterile absorbent cotton swab soaked by 0.9% sterile sodium chloride solution to wipe the hands, and then evenly coats the swab on the surface of the culture medium of the sampling plate.
A disinfectant group: the experimenter wears sterile gloves, completely immerses hands in 200ml of bacteria solution, keeps for 1min, lifts the hands out of the bacteria solution, cancels 5ml of the bacteria solution in the palm, forcibly rubs the hands until the liquid covers the whole hand surface, acts for 1min, wipes the hands with a sterile absorbent cotton swab soaked by 0.9% sterile sodium chloride solution after the bacteria solution on the hands is completely volatilized, and then evenly coats the swab on the surface of a culture medium of a sampling plate. The test sample and the reference sample were subjected to test operation using 5 kinds of fungal solutions, respectively.
Blank control group: the experimenter wears sterile gloves, swabs both hands with sterile absorbent cotton swabs soaked with 0.9% sterile sodium chloride solution, and then spread the swabs evenly on the surface of the medium on the sampling plate.
And (4) inverting the sampling plate, culturing in a constant-temperature incubator at 35.0 ℃ for 48h, taking out and checking.
TABLE 2 Experimental results of bare hand sampling method
TABLE 3 gloomycotes sampling test results
Note: the blank group was grown aseptically and the experiment was established.
And (3) detecting the insecticidal effect:
according to the requirements of the national ministry of agriculture for indoor pesticide efficacy test and evaluation of sanitary insecticides for pesticide registration (GB/T13917-2009), the insecticidal test mainly detects winged insects (light color library and mosquito aedes albopictus standard test insects) in national ministry of agriculture standard test.
The female adults and the halves of the females which do not suck blood from 3 days to 5 days after the test insects of culex pipiens pallens and aedes albopictus emerge are standard sensitive strain insects raised in insect raising rooms in the disease prevention and control center of the eastern war.
The compounding agent is prepared by compounding pesticide stock solution into 50 times of mother solution according to a preset scheme and a pre-test result, and the mother solution is diluted by 1:49 when in use.
TABLE 4 observation of the efficacy of the binary formulations of examples 1-2 against Culex pipiens pallens
TABLE 5 observation of the efficacy of the binary formulations of examples 1-2 against Aedes albopictus
Examples 3 to 4:
the formulation of the ultra-low temperature storage-resistant disinfection and disinsection compound preparation is shown in the table 6.
Table 6: formulation tables for examples 3 to 4
Low temperature storage experiment:
two bottles of each of the formulations of example 3 and example 4, 10ml each, were placed in a freezer at a predetermined temperature (20 degrees below zero, 40 degrees below zero), and after 24 hours, they were taken out and the liquids of the two formulations were observed to be solidified.
The experimental results are as follows: the formulations of example 3 and example 4 did not set when stored at-20 ℃ for 24 hours.
The formulations of example 3 and example 4 did not set when stored at-40 ℃ for 24 hours.
Claims (3)
1. An ultralow temperature storage-resistant disinfection and disinsection compound preparation comprises the following components:
(A) deltamethrin, bioallethrin or betathrin, synergistic ether, tributyl phosphate, emulsifier, ethanol and glycol;
(B) triclosan, sodium bicarbonate or disodium hydrogen phosphate, sodium nitrite.
2. The ultra-low temperature resistant storage disinfection insecticidal compound preparation according to claim 1, characterized in that: the weight ratio of each component is as follows:
insecticide: 5-8 parts of deltamethrin
Insecticide: 5-8 parts of bioallethrin or beta-cypermethrin
A synergist: 8-10 parts of synergistic ether
Defoaming agent: 1-1.5 parts of tributyl phosphate
Surfactant (b): 28-35 parts of emulsifier
Lysis-promoting and low temperature factors: 20-30 parts of ethanol
Low temperature factor: 2-5 parts of ethylene glycol
A disinfectant: 20-25 parts of triclosan
A stabilizer: 2-4 parts of sodium bicarbonate or disodium hydrogen phosphate
Corrosion inhibitor: 1-2 parts of sodium nitrite.
3. The ultra-low temperature resistant storage disinfection insecticidal compound preparation according to claim 1 or 2, characterized in that: the emulsifier comprises the following components in percentage by weight:
the special phenethyl phenol formaldehyde resin polyoxyethylene ether accounts for 25 percent;
25% of calcium dodecyl sulfonate;
styryl phenyl polyoxyethylene ether accounting for 25 percent;
25% of alkylphenol formaldehyde resin polyoxyethylene ether.
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| CN201910798193.2A CN110583686A (en) | 2019-08-27 | 2019-08-27 | Ultralow temperature resistant storage disinfection and disinsection compound preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113545357A (en) * | 2021-06-29 | 2021-10-26 | 中国人民解放军总医院第一医学中心 | Ultra-low temperature storage high-efficiency disinfection pesticide |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090118367A1 (en) * | 2007-11-07 | 2009-05-07 | Bayer Cropscience Lp | Insecticidal compositions with disinfectant |
| CN102318639A (en) * | 2011-05-15 | 2012-01-18 | 覃终 | Preparation and application with compound Alevaire of sterilization and insecticidal function |
| CN102630699A (en) * | 2012-04-01 | 2012-08-15 | 江苏扬农化工股份有限公司 | Compound insecticidal preparation containing d-trans-prallethrin chloride and application thereof |
| CN103891760A (en) * | 2012-12-25 | 2014-07-02 | 谭伟龙 | Efficient disinfectant pesticides |
-
2019
- 2019-08-27 CN CN201910798193.2A patent/CN110583686A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090118367A1 (en) * | 2007-11-07 | 2009-05-07 | Bayer Cropscience Lp | Insecticidal compositions with disinfectant |
| CN102318639A (en) * | 2011-05-15 | 2012-01-18 | 覃终 | Preparation and application with compound Alevaire of sterilization and insecticidal function |
| CN102630699A (en) * | 2012-04-01 | 2012-08-15 | 江苏扬农化工股份有限公司 | Compound insecticidal preparation containing d-trans-prallethrin chloride and application thereof |
| CN103891760A (en) * | 2012-12-25 | 2014-07-02 | 谭伟龙 | Efficient disinfectant pesticides |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113545357A (en) * | 2021-06-29 | 2021-10-26 | 中国人民解放军总医院第一医学中心 | Ultra-low temperature storage high-efficiency disinfection pesticide |
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