CN115885991A - Disinfectant composition and production process thereof - Google Patents
Disinfectant composition and production process thereof Download PDFInfo
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- CN115885991A CN115885991A CN202211389136.7A CN202211389136A CN115885991A CN 115885991 A CN115885991 A CN 115885991A CN 202211389136 A CN202211389136 A CN 202211389136A CN 115885991 A CN115885991 A CN 115885991A
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The application provides a disinfectant composition and a production process thereof, and relates to the technical field of disinfectants. The disinfectant composition comprises the following components in parts by weight: 2-5 parts of glutaraldehyde, 2-8 parts of quaternary ammonium salt surfactant, 10-15 parts of ethanol, 1-3 parts of quicklime, 1-3 parts of organic acid, 1-3 parts of inorganic acid, 1-3 parts of disodium ethylene diamine tetraacetate and 5-15 parts of traditional Chinese medicine. Adopt glutaraldehyde as the main materials of disinfectant in this application, collocation quaternary ammonium salt surfactant active and quick lime, its motion ability that strengthens quaternary ammonium salt surfactant active and the ability that combines with the cell membrane, and then strengthened glutaraldehyde and got into the speed in the cell, further improved and taken effect speed, made it have the advantage that the effect is fast, the disinfection can be high as veterinary disinfectant.
Description
Technical Field
The application relates to the technical field of disinfectants, in particular to a disinfectant composition and a production process thereof.
Background
Along with the rapid development of the livestock and poultry industry in China in large scale and intensification, the biological safety work of the livestock and poultry farm is particularly important. Epidemic diseases are important problems which must be faced by modern breeding industry, and the infection of pathogens can cause death of animals, reduction of production performance and serious economic loss. The disinfection measures are the main scheme for solving the biological safety problem of the farm at present, and can kill pathogenic microorganisms in the livestock house and the surrounding environment through disinfection, thereby cutting off the propagation path and achieving the effect of preventing diseases.
Glutaraldehyde has surface tension property, can penetrate blood and exudate without coagulating protein, still has the activity of killing microorganisms in the presence of organic matters, has no corrosion effect on metal, rubber and plastics, is the first disinfectant for medical instruments afraid of high temperature and corrosion, and is used for disinfecting a plurality of medical instruments. Meanwhile, the disinfectant has the advantages of good disinfection effect and the like, and is a preferred disinfectant for the environment or the drivers in the farm. But it is limited in its application because it has moderate toxicity, strong irritation, causes allergy, conjunctival and nasal irritation, and is expensive, and it is generally required to reduce the glutaraldehyde content in the disinfectant for use. But when the glutaraldehyde in the disinfectant is reduced, the effect of the disinfectant is affected, so that the phenomena of slow effect taking and poor sterilization effect are generated.
In view of the above situation, the research of the veterinary disinfectant composition with quick response, good bactericidal effect and small irritation has great significance.
Disclosure of Invention
The application aims to provide a disinfectant composition which has the advantages of quick response and good bactericidal effect.
Another object of the present application is to provide a process for the production of a disinfectant composition, which has the advantage of simplicity and convenience.
The technical problem to be solved by the application is solved by adopting the following technical scheme.
In one aspect, the embodiments herein provide a disinfectant composition comprising the following components in parts by weight: 2-5 parts of glutaraldehyde, 2-8 parts of quaternary ammonium salt surfactant, 10-15 parts of ethanol, 1-3 parts of quicklime, 1-3 parts of organic acid, 1-3 parts of inorganic acid, 1-3 parts of disodium ethylene diamine tetraacetate and 5-15 parts of traditional Chinese medicine.
In another aspect, the present application provides a process for producing a disinfectant composition, comprising the steps of:
drying the Chinese medicinal materials, pulverizing, and sieving with 200 mesh sieve to obtain Chinese medicinal powder;
mixing the traditional Chinese medicine powder with glutaraldehyde, quaternary ammonium salt surfactant, ethanol, quicklime, organic acid, inorganic acid, disodium ethylene diamine tetraacetate and traditional Chinese medicine to obtain the disinfectant composition.
In a further aspect, the present application also provides a use of the disinfectant composition in a disinfectant product for animals, which is prepared by the following steps: the disinfectant composition is mixed with water and then sprayed to the environment of poultry and livestock.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
in the application, glutaraldehyde is used as a main raw material of the disinfectant, intermolecular polymerization can be carried out when the disinfectant is used, an aldol type unsaturated polymer is formed, the polymer is mutually crosslinked with lysine in a bacterium body after being contacted with bacteria and fungi, and the glutaraldehyde enters the bacterium body, so that the membrane penetration brittleness is improved, the intracellular substances are leaked, and finally, the bacterium is cracked and killed. The cell surface sterilizing agent is characterized in that a quaternary ammonium salt surfactant is matched on the basis of glutaraldehyde, the quaternary ammonium salt surfactant is used as a carrier for the glutaraldehyde, the quaternary ammonium salt surfactant is provided with positive ions, a fungus cell membrane is provided with negative ions, and when sterilization is carried out, the quaternary ammonium salt surfactant can be combined with the surface of an anionic bacterium cell membrane, so that the surface tension of a solution is reduced, the combining capacity of the glutaraldehyde and cells is increased, and the glutaraldehyde and the cells are fed into the cells to act.
The quick lime is added on the basis of the glutaraldehyde and the quaternary ammonium salt surfactant, so that on one hand, the quick lime has the sterilization and disinfection effects and increases the disinfection effect of the final disinfectant composition; on the other hand, when in use, the quicklime is contacted with water to release heat, the temperature of the whole disinfectant is improved, the movement capacity of the quaternary ammonium salt surfactant and the capacity of combining with cell membranes are enhanced, the speed of glutaraldehyde entering cells is further enhanced, the onset rate is further improved, and the disinfectant has the advantages of quick onset and high disinfection capacity.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.
It should be noted that, in the present application, the embodiments and features of the embodiments may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
The disinfectant composition comprises the following components in parts by weight: 2-5 parts of glutaraldehyde, 2-8 parts of quaternary ammonium salt surfactant, 10-15 parts of ethanol, 1-3 parts of quicklime, 1-3 parts of organic acid, 1-3 parts of inorganic acid, 1-3 parts of disodium ethylene diamine tetraacetate and 5-15 parts of traditional Chinese medicine.
In the application, glutaraldehyde is used as a main raw material of the disinfectant, intermolecular polymerization can be carried out when the disinfectant is used, an aldol type unsaturated polymer is formed, the polymer is mutually crosslinked with lysine in a bacterium body after being contacted with the bacterium and the fungus, and the glutaraldehyde enters the bacterium body, so that the membrane penetration brittleness is improved, intracellular substances are leaked, and finally the bacterium is cracked and killed. The cell surface sterilizing agent is characterized in that a quaternary ammonium salt surfactant is matched on the basis of glutaraldehyde, the quaternary ammonium salt surfactant is used as a carrier for the glutaraldehyde, the quaternary ammonium salt surfactant is provided with positive ions, a fungus cell membrane is provided with negative ions, and when sterilization is carried out, the quaternary ammonium salt surfactant can be combined with the surface of an anionic bacterium cell membrane, so that the surface tension of a solution is reduced, the combining capacity of the glutaraldehyde and cells is increased, and the glutaraldehyde and the cells are fed into the cells to act.
The quick lime is added on the basis of the glutaraldehyde and the quaternary ammonium salt surfactant, so that on one hand, the quick lime has the sterilization and disinfection effects and increases the disinfection effect of the final disinfectant composition; on the other hand, when in use, the quicklime is contacted with water to release heat, the temperature of the whole disinfectant is improved, the movement capacity of the quaternary ammonium salt surfactant and the capacity of combining with cell membranes are enhanced, the speed of glutaraldehyde entering cells is further enhanced, the onset rate is further improved, and the disinfectant has the advantages of quick onset and high disinfection capacity.
According to the application, traditional Chinese medicinal materials are added on the basis of the matching, and on one hand, the traditional Chinese medicinal materials can play a role in sterilization, and on the other hand, the functions of animals can be adjusted, so that the animals have better physical resistance to viruses and bacteria.
Organic acid, inorganic acid and disodium ethylene diamine tetraacetate are also added in the disinfectant, so that the antibacterial and antivirus effects are improved on one hand, and the pH value of the disinfectant is adjusted on the other hand.
In some embodiments of the present application, the disinfectant composition comprises the following components in parts by weight: 3 parts of glutaraldehyde, 5 parts of quaternary ammonium salt surfactant, 12 parts of ethanol, 2 parts of quicklime, 2 parts of organic acid, 2 parts of inorganic acid, 2 parts of disodium ethylene diamine tetraacetate and 10 parts of traditional Chinese medicine.
In some embodiments of the present application, the organic acid is one or more of citric acid, salicylic acid, oxalic acid, malic acid, and tartaric acid.
In some embodiments of the present application, the inorganic acid is one or more of hydrochloric acid, sulfuric acid, or phosphoric acid.
In some embodiments of the present application, the quaternary ammonium salt-based surfactant is an alkyl dimethyl benzyl ammonium-type surfactant or an alkyl trimethyl ammonium salt-type surfactant.
In some embodiments of the present application, the above-mentioned Chinese medicinal materials include at least two of argyi leaf, peppermint, clove, phellodendron bark, forsythia fruit, honeysuckle, houttuynia cordata and dandelion.
A process for producing a disinfectant composition comprising the steps of:
drying the Chinese medicinal materials, pulverizing, and sieving with 200 mesh sieve to obtain Chinese medicinal powder;
mixing the traditional Chinese medicine powder with glutaraldehyde, quaternary ammonium salt surfactant, ethanol, quicklime, organic acid, inorganic acid, disodium ethylene diamine tetraacetate and traditional Chinese medicine to obtain the disinfectant composition.
The application of a disinfectant composition in a veterinary disinfectant product comprises the following steps: the disinfectant composition is mixed with water and sprayed to poultry and livestock environment.
In some embodiments of the present application, the disinfectant composition is mixed with water in a ratio of 1: (10-50).
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A disinfectant composition is prepared by the following steps:
taking 20g of dried folium artemisiae argyi, 30g of mint and 50g of honeysuckle, grinding into powder, and sieving with a 200-mesh sieve to obtain traditional Chinese medicine powder;
mixing 30g of glutaraldehyde, 50g of alkyl trimethylammonium salt type surfactant, 120g of absolute ethyl alcohol, 20g of quick lime, 10g of citric acid, 10g of malic acid, 20g of hydrochloric acid and 20g of ethylene diamine tetraacetic acid with the traditional Chinese medicine powder to obtain the disinfectant composition of the embodiment.
The disinfectant composition of this example was stored in a low temperature, dark environment.
When in use, the disinfectant combination is mixed with water according to the ratio of 1:20, stirring and dissolving, and spraying.
Example 2
A disinfectant composition is prepared by the following steps:
taking 10g of dried folium artemisiae argyi and 40g of dried herba houttuyniae, grinding into powder, and sieving with a 200-mesh sieve to obtain traditional Chinese medicine powder;
the disinfectant composition of the present example was obtained by mixing the above-mentioned Chinese medicinal powders with 20g of glutaraldehyde, 40g of alkyltrimethylammonium salt type surfactant, 130g of anhydrous ethanol, 30g of quicklime, 10g of citric acid, 20g of oxalic acid, 20g of sulfuric acid and 30g of disodium ethylenediaminetetraacetate.
The disinfectant composition of this example was stored in a low temperature, dark environment.
When in use, the disinfectant combination is mixed with water according to the ratio of 1: mixing at a mass ratio of 50, stirring to dissolve, and spraying.
Example 3
A disinfectant composition is prepared by the following steps:
taking 30g of dried clove, 20g of fructus forsythiae, 20g of dandelion and 20g of phellodendron, grinding into powder, and sieving with a 200-mesh sieve to obtain traditional Chinese medicine powder;
mixing 50g of glutaraldehyde, 80g of alkyl dimethyl ammonium salt type surfactant, 100g of absolute ethyl alcohol, 25g of quicklime, 10g of citric acid, 20g of sulfuric acid and 20g of ethylene diamine tetraacetic acid with the traditional Chinese medicine powder to obtain the disinfectant composition of the embodiment.
The disinfectant composition of this example was stored in a low temperature, dark environment.
When in use, the disinfectant combination is mixed with water according to the ratio of 1:30, stirring and dissolving, and spraying.
Example 4
A disinfectant composition is prepared by the following steps:
taking 150g of dried mint, grinding into powder, and sieving with a 200-mesh sieve to obtain traditional Chinese medicine powder;
mixing 30g of glutaraldehyde, 50g of alkyl trimethylammonium salt type surfactant, 150g of absolute ethyl alcohol, 10g of quick lime, 20g of tartaric acid, 20g of hydrochloric acid and 25g of ethylene diamine tetraacetic acid with the traditional Chinese medicine powder to obtain the disinfectant composition of the embodiment.
The disinfectant composition of this example was stored in a low temperature, dark environment.
When in use, the disinfectant combination is mixed with water according to the ratio of 1:40, stirring and dissolving, and spraying.
Example 5
A disinfectant composition is prepared by the following steps:
taking 50g of dried clove and 20g of phellodendron bark and 10g of honeysuckle, grinding into powder, and sieving with a 200-mesh sieve to obtain traditional Chinese medicine powder;
mixing 40g of glutaraldehyde, 60g of alkyl trimethylammonium salt type surfactant, 130g of absolute ethyl alcohol, 10g of quick lime, 20g of tartaric acid, 10g of hydrochloric acid and 15g of ethylene diamine tetraacetic acid with the traditional Chinese medicine powder to obtain the disinfectant composition of the embodiment.
The disinfectant composition of this example was stored in a low temperature, dark environment.
When in use, the disinfectant combination is mixed with water according to the ratio of 1:40, stirring and dissolving, and spraying.
Example 6
A disinfectant composition is prepared by the following steps:
taking 40g of dried clove, 20g of folium artemisiae argyi and 20g of honeysuckle, grinding into powder, and sieving with a 200-mesh sieve to obtain traditional Chinese medicine powder;
mixing 40g of glutaraldehyde, 50g of alkyl trimethyl ammonium salt type surfactant, 100g of absolute ethyl alcohol, 10g of quicklime, 20g of salicylic acid, 10g of citric acid, 10g of hydrochloric acid and 20g of ethylene diamine tetraacetic acid with the above traditional Chinese medicine powder to obtain the disinfectant composition of the embodiment.
The disinfectant composition of this example was stored in a low temperature, dark environment.
When in use, the disinfectant combination is mixed with water according to the ratio of 1:20, stirring and dissolving, and spraying.
Example 7
A disinfectant composition is prepared by the following steps:
taking 60g of dried folium artemisiae argyi and 40g of dried honeysuckle, grinding into powder, and sieving with a 200-mesh sieve to obtain traditional Chinese medicine powder;
mixing 50g of glutaraldehyde, 80g of alkyl trimethylammonium salt surfactant, 100g of absolute ethyl alcohol, 10g of quicklime, 10g of salicylic acid, 10g of citric acid, 30g of phosphoric acid and 20g of disodium ethylenediamine tetraacetic acid with the above traditional Chinese medicine powder to obtain the disinfectant composition of the embodiment.
The disinfectant composition of this example was stored in a low temperature, dark environment.
When in use, the disinfectant combination is mixed with water according to the ratio of 1:30, stirring and dissolving, and spraying.
Example 8
A disinfectant composition is prepared by the following steps:
taking 40g of dried clove, 20g of folium artemisiae argyi, 10g of golden cypress, 10g of houttuynia cordata, 10g of fructus forsythiae and 10g of honeysuckle, grinding into powder, and sieving with a 200-mesh sieve to obtain traditional Chinese medicine powder;
30g of glutaraldehyde, 50g of alkyl trimethylammonium salt surfactant, 100g of absolute ethyl alcohol, 30g of quicklime, 10g of salicylic acid, 10g of citric acid, 10g of phosphoric acid and 10g of disodium ethylene diamine tetraacetate are mixed with the traditional Chinese medicine powder to obtain the disinfectant composition of the embodiment.
The disinfectant composition of this example was stored in a low temperature, dark environment.
When in use, the disinfectant combination is mixed with water according to the ratio of 1:30, stirring and dissolving, and spraying.
Comparative example 1
This comparative example is substantially the same as example 1 except that it does not contain an alkyltrimethylammonium salt type surfactant.
Comparative example 2
This comparative example is substantially the same as example 1 except that a nonionic surfactant is used in place of the alkyltrimethylammonium salt type surfactant.
Comparative example 3
This comparative example is substantially the same as example 1 except that quicklime was not added to this comparative example.
Comparative example 4
This comparative example is substantially the same as example 1 except that no traditional Chinese medicinal materials are added.
Test examples
This test example tests the disinfectant compositions of the examples and comparative examples of the present application against escherichia coli, staphylococcus aureus and candida albicans.
According to the relevant regulations in GB 4789.2-2010 food safety national standard food microbiology test colony number determination, when interacting with disinfectant, the concentration of bacteria liquid is ensured to be 1 multiplied by 10 7 -5×10 8 cfu/mL, therefore, before the test, the bacterial fluid was diluted with sterile 0.03mol/L PBS to the concentration required for the test.
In this test example, 5 experimental groups (3 parallel experiments for each experimental group) were provided, and 4.5mL of a bacterial solution (concentration 1.5X 10) was added to each EP tube 7 cfu/mL), then 1mL of the disinfectant composition prepared in example 1 and comparative examples 1-4 was added, shaken, 0.5mL of the mixed solution was taken out with a pipette after 3min, 10min and 20min, respectively, spread on a medium, cultured at 37 ℃ for 24h, and then counted and sterilized. The results are shown in tables 1 to 3.
TABLE 1 bactericidal Effect of disinfectants on E.coli
TABLE 2 bactericidal Effect of disinfectants on Staphylococcus aureus
TABLE 3 germicidal Effect of disinfectants on Candida albicans
Note: the data above are the average of 3 replicates.
As can be seen from tables 1 to 3, the disinfectant composition prepared in example 1 of the present application has a strong killing ability against Escherichia coli, staphylococcus aureus and Candida albicans, and can basically achieve a strong effect within 3min, which indicates that the disinfectant composition prepared in example 1 of the present application has the advantage of a fast onset of action.
In comparative example 1, no quaternary ammonium salt surfactant is added, the sterilization rate of the composition is kept to be increased within 20min, and the sterilization rate of the composition is close to 100% within 20min, which shows that the composition has strong sterilization capability within 20min but takes effect slowly.
In comparative example 2, the effect of the nonionic surfactant is not much different from that of comparative example 2, which indicates that the nonionic surfactant has no effect in the disinfectant of the present application.
The absence of quicklime and the traditional Chinese medicines in comparative examples 3 and 4 has a certain negative effect on the disinfectant.
In summary, the disinfectant composition and the production process thereof provided by the embodiment of the application have the following advantages:
in the application, glutaraldehyde is used as a main raw material of the disinfectant, intermolecular polymerization can be carried out when the disinfectant is used, an aldol type unsaturated polymer is formed, the polymer is mutually crosslinked with lysine in a bacterium body after being contacted with the bacterium and the fungus, and the glutaraldehyde enters the bacterium body, so that the membrane penetration brittleness is improved, intracellular substances are leaked, and finally the bacterium is cracked and killed. The cell surface sterilizing agent is characterized in that a quaternary ammonium salt surfactant is matched on the basis of glutaraldehyde, the quaternary ammonium salt surfactant is used as a carrier for the glutaraldehyde, the quaternary ammonium salt surfactant is provided with positive ions, a fungus cell membrane is provided with negative ions, and when sterilization is carried out, the quaternary ammonium salt surfactant can be combined with the surface of an anionic bacterium cell membrane, so that the surface tension of a solution is reduced, the combining capacity of the glutaraldehyde and cells is increased, and the glutaraldehyde and the cells are fed into the cells to act.
The quick lime is added on the basis of the glutaraldehyde and the quaternary ammonium salt surfactant, so that on one hand, the quick lime has the sterilization and disinfection effects and increases the disinfection effect of the final disinfectant composition; on the other hand, when in use, the quicklime is contacted with water to release heat, the temperature of the whole disinfectant is improved, the movement capacity of the quaternary ammonium salt surfactant and the capacity of combining with cell membranes are enhanced, the speed of glutaraldehyde entering cells is further enhanced, the onset rate is further improved, and the disinfectant has the advantages of quick onset and high disinfection capacity.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (9)
1. The disinfectant composition is characterized by comprising the following components in parts by weight: 2-5 parts of glutaraldehyde, 2-8 parts of quaternary ammonium salt surfactant, 10-15 parts of ethanol, 1-3 parts of quicklime, 1-3 parts of organic acid, 1-3 parts of inorganic acid, 1-3 parts of disodium ethylene diamine tetraacetate and 5-15 parts of traditional Chinese medicine.
2. The disinfectant composition according to claim 1, comprising the following components in parts by weight: 3 parts of glutaraldehyde, 5 parts of quaternary ammonium salt surfactant, 12 parts of ethanol, 2 parts of quicklime, 2 parts of organic acid, 2 parts of inorganic acid, 2 parts of disodium ethylene diamine tetraacetate and 10 parts of traditional Chinese medicine.
3. A disinfectant composition according to claim 1 or 2 wherein said organic acid is one or more of citric acid, salicylic acid, oxalic acid, malic acid and tartaric acid.
4. A disinfectant composition according to claim 1 or 2 wherein said inorganic acid is one or more of hydrochloric acid, sulphuric acid or phosphoric acid.
5. A disinfectant composition according to claim 1 or 2, wherein said quaternary ammonium salt surfactant is an alkyldimethylbenzyl ammonium type surfactant or an alkyltrimethylammonium salt type surfactant.
6. A disinfectant composition according to claim 1 or 2, wherein said Chinese medicinal materials comprise at least two of argyi leaf, peppermint, clove, phellodendron bark, forsythia fruit, honeysuckle, houttuynia cordata and dandelion.
7. A process for the production of a disinfectant composition according to any one of claims 1 to 6, comprising the steps of:
drying the Chinese medicinal materials, pulverizing, and sieving with 200 mesh sieve to obtain Chinese medicinal powder;
mixing the traditional Chinese medicine powder with glutaraldehyde, quaternary ammonium salt surfactant, ethanol, quicklime, organic acid, inorganic acid, disodium ethylene diamine tetraacetate and traditional Chinese medicine to obtain the disinfectant composition.
8. Use of a disinfectant composition according to any of claims 1 to 6 in a veterinary disinfectant product, in a method of use comprising: the disinfectant composition is mixed with water and sprayed to poultry and livestock environment.
9. Use of a disinfectant composition according to claim 8 in a veterinary disinfectant product, wherein the disinfectant composition is mixed with water in a ratio of 1: (10-50).
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