CN103977155A - Cleaning-free compound hand sanitizer and preparation method thereof - Google Patents
Cleaning-free compound hand sanitizer and preparation method thereof Download PDFInfo
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Abstract
The invention provides a cleaning-free compound hand sanitizer. The cleaning-free compound hand sanitizer is characterized by comprising the following components by mass-to-volume ratio: 0.45-0.55% of chlorhexidine, 0.05-0.15% of triclosan, 0.12-12% of Chinese herb extract compound, 50-60% of alcohols, 0.1-3% of nonionic surfactant, 0.5-2% of penetrant, and the balance of water. The cleaning-free compound hand sanitizer is stable in performance, broad-spectrum antibacterial, fast in sterilization, free of gooey feeling after hands are washed, good in moisturizing effect, mild in odor, and free of stimulation. The invention also discloses a preparation method of the cleaning-free compound hand sanitizer. The preparation method is simple and applicable to large-scale production and application.
Description
Technical field
The present invention relates to antibiotic and sterilizing field, more specifically, relate to hand sanitizing fluid field, particularly a kind of disposable compound recipe hand sanitizing fluid and preparation method thereof.
Background technology
Disposable handwashing liquid, do not need water to rinse the effect of washing one's hands of just playing, compared with general handwashing liquid, disposable handwashing liquid is not limited by or not water source, be suitable for, under hydropenia condition, hand is carried out to cleaning and disinfection use, be particularly useful for some crowd in outside work or outdoor travel, as geological prospecting personnel, driver, miner etc.As the renewal product of traditional handwashing liquid apparatus fancy soap, handwashing liquid has broad-spectrum antibacterial, avoids the advantages such as secondary pollution.In addition, being also applicable to health care personnel uses at some occasion handwashing disinfection.The solvent of disposable hand sanitizing fluid mainly adopts volatile organic solvent, and wherein conventional is alcoholic solvent, considers safety non-toxic requirement, especially adopts ethanol, isopropyl alcohol for maximum.Conveniently save trouble when this series products uses because of it Hen Shou consumer and medical worker welcomes, and sales volume is very large in recent years.
The kind of existing disposable handwashing liquid is more, in some handwashing liquid, taking the alcohols (exceeding 80%<v/v>) of high concentration as solvent, has strong sharp aroma, is difficult to be accepted by consumer; Some handwashing liquid antimicrobial components are single, are difficult to reach the effect of long-acting bacteriostatic.Patent CN10394909C has announced in a kind of disposable handwashing liquid and preparation method thereof and has introduced the abnormal smells from the patient with tea tree oil parcel ethanol, although played certain effect, its technique is more loaded down with trivial details, and production cost is higher.The primary raw material of the disposable antiseptic hand washing liquid and preparation method thereof of its announcement and proportioning for (percentage by weight) are: ethanol: 57%～65%; Tea tree oil: 0.1%～2%; Card ripple: 3%～5%; Antibacterial triclosan: 0.05%～0.1%, surplus is wetting agent, cosolvent, solubilizing agent etc., this formula utilizes tea tree oil by the abnormal smells from the patient parcel of ethanol, but also has added a large amount of surfactant card ripples, very glutinous greasy after making to wash one's hands, rapid-curing cutback weak effect, feels very bad.In the washing-free antibacterial hand sanitizer preparation method of announcing at Chinese invention patent CN101766552B, technologist joins skin protectant and chlorhexidine salt in ethanol, in the time of 30～70 DEG C of temperature, dissolves, and forms alcoholic solution; Thickening agent, surfactant and silver nitrate are added in deionized water, form aqueous solution; Then aqueous solution is joined in alcoholic solution, regulate its pH, make disposable handwashing liquid.This technique needs heating, has increased energy consumption; In addition, in handwashing liquid, add expensive silver nitrate, increased production cost, and handwashing liquid is in use drained into heavy metal silver ion in external environment condition unavoidably, to environment.
So a kind of sterilization is quick and durable, can potent kill bacteria, processing technology is simple, can rapid-curing cutback, with low cost can and not wash one's hands to environment after without sticky feel, the antibacterial disposable hand sanitizing fluid that good, the not dry hands of moistening effect there is no obvious sharp aroma is extremely to have practical value.
Summary of the invention
One object of the present invention is exactly the problems and shortcomings for above existence, provide a kind of stable performance, broad-spectrum antiseptic, sterilization fast, wash one's hands after without glutinous soapy feeling and moistening effect is good, abnormal smells from the patient is gentle, with low cost can be to the quick-acting antibacterial disposable compound recipe hand sanitizing fluids of the brute force of environment.
To achieve these goals, disposable compound recipe hand sanitizing fluid of the present invention, is characterized in, raw material comprises following component, and each constituent mass volume ratio is:
Chlorhexidine 0.45%～0.55%;
Triclosan 0.05%～0.15%;
Chinese herbal medicine extract complex 0.12%～12%;
Alcohols 50%～60%;
Non-ionic surface active agent 0.1%～3%;
Penetrating agent 0.5%～2%;
All the other are water.
Preferably, described Chinese herbal medicine extract complex comprises following component, and each component mass volume ratio in described disposable compound recipe hand sanitizing fluid is:
Tannin: 0.01%～1%;
Oleum Eucalypti: 0.01%～1%;
Oleum menthae: 0.01%～1%;
Oleum Camphora: 0.01%～1%;
Herba Violae: 0.01%～1%;
Flos Lonicerae extract: 0.01%～1%;
Radix Glycyrrhizae extract: 0.01%～1%;
Cortex Phellodendri extract: 0.01%～1%;
Fructus cnidii extract: 0.01%～1%;
Galla halepensis extract: 0.01%～1%;
Balsamiferou Blumea Herb extract: 0.01%～1%;
Herba Andrographis extract: 0.01%～1%.
Preferably, described alcohols comprises following component, and each component mass volume ratio in described disposable compound recipe hand sanitizing fluid is:
Ethanol: 50%～60%;
Dipropylene glycol: 0.5%～2%.
Preferably, described ionic surfactant pack is drawn together following component, and each component mass volume ratio in described disposable compound recipe hand sanitizing fluid is:
Alkyl polyglucoside: 0.1%～2%;
Polyvinylpyrrolidone: 0.01%～1%.
Preferably, described disposable compound recipe hand sanitizing fluid also comprises the component of following mass volume ratio:
Citric acid: 0.1%～2%;
Disodiumedetate: 0.01%～1%.
Beneficial effect of the present invention is: sterilize quick and durable, effect 2min, is all greater than 99.90% to antibacterial average kill ratio, kills logarithm value >5.00; The sticky feel of nothing after washing one's hands, good, the not dry hands of moistening effect; And without obvious sharp aroma.
Disposable hand sanitizing fluid of the present invention is owing to having adopted a kind of novel good non-ionic surface active agent alkyl-glucoside and polyvinylpyrrolidone as stabilizing agent, it has the effect of moisturizing concurrently, the chemical skin protectant that simultaneously adopts again multiple Chinese herbal medicine degerming skin care ingredient (such as tannin, Flos Lonicerae extract, Oleum Eucalypti etc.) and avoided using a large amount of greasy is as glycerol etc., make hand-washing effect excellent, imperceptible any glutinous soapy feeling.In addition, the addition of this formula handwashing liquid ethanol is quality volume fraction 50%～60%, can meet rapid-curing cutback effect, and simultaneously ethanol content is compared more on the low sidely with similar, and therefore penetrating odor is lighter.And in formula, add multiple herbal component, can reach the effect of extraordinary preserving moisture and protecting skin, made to use rear skin can not seem dry and astringent, more moistened care both hands.
A maximum advantage of disposable compound recipe hand sanitizing fluid of the present invention is rapidity, broad spectrum activity, the completeness of sterilization.Sterilization component in composition of raw materials comprises Chlorhexidine, triclosan, ethanol and Chinese herbal medicine extract complex, and their sterilization mechanism and bactericidal range are different.In formula, contain the ethanol of higher concentration, can destroy the cell wall of antibacterial and then act on antibacterial inside making its protein coagulating degeneration, hinder its metabolic function.The selected multiple herbal component with antibacterial or sterilizing function in formula, these Chinese herbal medicine extracts act on the cell membrane of antibacterial, hinder the absorption of antibacterial to nutrient substance such as growth essential amino acid, saccharide, inorganic matters, thus the generation of anti-bacteria; In addition, because can also stoping the breathing of antibacterial, these high molecular Chinese herbal medicine extracts reach the effect of killing antibacterial.Such as Oleum menthae is wherein rich in flavonoid glycoside and multiple organic acid, staphylococcus aureus, escherichia coli, streptococcus and Salmonella are had to stronger inhibitory action; Flos Lonicerae extract has obvious inhibitory action to staphylococcus aureus, Bacillus typhi, Diplococcus pneumoniae, bacillus pyocyaneus and influenza virus; The andrographolide containing in Herba Andrographis extract and neoandrographolide have obvious inhibitory action to escherichia coli; Some composition in Cortex Phellodendri extract can anti-bacteria breathing and RNA synthetic, the various bacteria such as staphylococcus aureus, streptococcus pneumoniae, tubercule bacillus, bacillus pyocyaneus, dysentery bacterium are all had to extraordinary inhibitory action.Chlorhexidine is as the main bactericidal component in formula, its sterilization mechanism is that it has cation surface activating, be easy to be adsorbed on electronegative bacterial cell membrane, cause the damage of breaking of bacterial cell membrane, make low-molecular-weight Cytoplasm become to distribute; In addition, the dehydrogenase that Chlorhexidine can anti-bacteria inside and oxidase isoreactivity enzyme synthetic, makes it that dysbolismus occur, thereby causes antibacterial death; Chlorhexidine is kill vegetative forms of bacteria effectively, but tubercule bacillus, fungus and bacterial spore are only had to inhibitory action, also invalid to virus.The bactericidal component of its pivotal role of another in formula is triclosan, and it is a kind of high-effective broad-spectrum fungicide, acts on the cell membrane of antibacterial, destroys cell membrane, its content is leaked and reaches the object of quick sterilization; Triclosan all has efficient inhibitory or killing effect to common antibacterial, fungus and virus, but all has good killing property for multiple gram positive bacteria and gram negative bacteria, and effect is lasting rapidly.As can be seen here, these several antibacterial compound recipes are fitted in together, the defect that used time fungicidal spectrum is narrow, germicidal efficiency is low of doing that makes up one-component that can be real, and reach a kind of Synergistic biocidal, work in coordination with the effect of entering altogether, thereby meet the sterilization " powerful quick-acting " of the disposable compound recipe hand sanitizing fluid of this formula.
Another object of the present invention is to provide the preparation method of the disposable compound recipe hand sanitizing fluid of knowing clearly, and its feature is, comprises the following steps:
Step 1: add successively the Chlorhexidine of 0.45%～0.55% mass volume ratio, the ethanol of 50%～60% mass volume ratio, then shake up, fully mix;
Step 2: the mixture of step 1 gained is added successively to the triclosan of 0.05%～0.15% mass volume ratio, the dipropylene glycol of 0.5%～2% mass volume ratio, the alkyl polyglucoside of 0.1%～2% mass volume ratio, the Chinese herbal medicine extract complex of 0.12%～12% mass volume ratio under constantly stirring, add the disodiumedetate of 0.01%～1% mass volume ratio after stirring;
Step 3: the polyvinylpyrrolidone of 0.01%～1% mass volume ratio is dissolved in the water, is added the about 30min of stirring and evenly mixing in the solution of step 2 gained;
Step 4: then the product of step 3 gained is added to essence, pigment, regulate between its pH to 7～9 with the citric acid solution of mass fraction 20%, supply the water of surplus, the disposable compound recipe hand sanitizing fluid that acquisition will be prepared.
The beneficial effect of above-mentioned preparation method is: this disposable hand sanitizing fluid production technology is simple, only need to simply stir, and does not need heating, and compared to the prior art, its method is simple to operate, and cost-saving.And because production technology is simple, be applicable to industrialized great production.
Detailed description of the invention
In order more clearly to understand technology contents of the present invention, describe in detail especially exemplified by following examples.
1 experimental section
1.1 experimental raw
1.2 experimental instrument and equipment
1000ml beaker, glass stirring rod, YP2000 type electronic balance, FA2004 type analysis balance, PHS-3C type pH meter, 250ml conical flask, L5S type ultraviolet-uisible spectrophotometer, 1000ml volumetric flask, 500ml volumetric flask, 200ml volumetric flask, 100ml volumetric flask, 50ml volumetric flask, stability test case.
The preparation of 1.3 disposable hand sanitizing fluids
Proportioning raw materials (w/v): Chlorhexidine: 0.45%～0.55%; Triclosan: 0.05～0.15%; Ethanol: 50%～60%; Dipropylene glycol: 0.5%～2%; Alkyl polyglucoside (APG0810): 0.1%～2%; Polyvinylpyrrolidone (PVP-K30): 0.01%～1%; Citric acid: 0.1%～2%; Disodiumedetate: 0.01%～1%; Chinese herbal medicine extract complex (tannin: 0.01%～1%, Oleum Eucalypti: 0.01%～1%, Oleum menthae: 0.01%～1%, Oleum Camphora: 0.01%～1%; Herba Violae: 0.01%～1%, Flos Lonicerae extract: 0.01%～1%, Radix Glycyrrhizae extract: 0.01%～1%, Cortex Phellodendri extract: 0.01%～1%, Fructus cnidii extract: 0.01%～1%, Galla halepensis extract: 0.01%～1%, Balsamiferou Blumea Herb extract: 0.01%～1%, Herba Andrographis extract: 0.01%～1%) essence, pigment are appropriate; Water surplus.
Add successively Chlorhexidine, ethanol by proportioning raw materials, then shake up, fully mix; Then under constantly stirring, add successively triclosan, dipropylene glycol, alkyl polyglucoside, Chinese herbal medicine extract complex, after stirring, add disodiumedetate; Polyvinylpyrrolidone is dissolved in appropriate water, adds the about 30min of stirring and evenly mixing in above-mentioned solution; Then add essence, pigment, regulating its pH with citric acid solution (mass fraction 20%) is between 7～9, supplies the water of surplus, obtains product.
The mensuration of 1.4 Chlorhexidine content
Adopt the Chlorhexidine content in ultraviolet-visible spectrophotometer L5S working sample.Chlorhexidine has characteristic peak at 260nm place.First, measure the standard curve of Chlorhexidine, taking basal liquid as solvent, first configure the Chlorhexidine of 5000mg/L, dilute with distilled water, make the concentration of preparing Chlorhexidine be respectively 5mg/L, 7.5mg/L, 10mg/L, 12.5mg/L, 25mg/L, 50mg/L, after visible-ultraviolet spectrophotometer L5S scanning, obtain its light absorption value, calculate standard regressive method by correlation and regression method.Sample solution is diluted to (concrete concentration is made by oneself), measure its absorbance, calculate its concentration.
1.5 Accelerated stability test methods
Operate according to the sterile products stability test method specifying in " disinfection technology standard " (version in 2002) Part II.Product is put in 37 DEG C of calorstats, to place after three months and take out, and with after deionized water dilution, measure according to the method described above its absorbance, then substitution standard regressive method, calculates its concentration.Then calculate its rate of descent, as stability experiment result.
2 results and discussion
2.1 hand-washing effects and production technology overall merit
The disposable hand sanitizing fluid of producing according to the preparation of this formula is owing to having adopted a kind of novel good non-ionic surface active agent alkyl-glucoside and polyvinylpyrrolidone to have the effect of moisturizing concurrently as stabilizing agent simultaneously, the chemical skin protectant that simultaneously adopts again multiple Chinese herbal medicine degerming skin care ingredient (such as tannin, Flos Lonicerae extract, Oleum Eucalypti etc.) and avoided using a large amount of greasy is as glycerol etc., make hand-washing effect excellent, imperceptible any glutinous soapy feeling.In addition, the addition of this formula handwashing liquid ethanol is quality volume fraction 50%～60%, can meet rapid-curing cutback effect, and simultaneously ethanol content is compared more on the low sidely with similar, and therefore penetrating odor is lighter.And in formula, add multiple herbal component, can reach the effect of extraordinary preserving moisture and protecting skin, made to use rear skin can not seem dry and astringent, more moistened care both hands.
The disposable hand sanitizing fluid production technology of this formula is simple, only need to simply stir, and does not need heating.
A maximum bright spot of the disposable compound recipe hand sanitizing fluid of this formula is rapidity, broad spectrum activity, the completeness of sterilization.Sterilization component in formula comprises Chlorhexidine, triclosan, ethanol and Chinese herbal medicine extract complex, and their sterilization mechanism and bactericidal range are different.In formula, contain the ethanol of higher concentration, can destroy the cell wall of antibacterial and then act on antibacterial inside making its protein coagulating degeneration, hinder its metabolic function.The selected multiple herbal component with antibacterial or sterilizing function in formula, these Chinese herbal medicine extracts act on the cell membrane of antibacterial, hinder the absorption of antibacterial to nutrient substance such as growth essential amino acid, saccharide, inorganic matters, thus the generation of anti-bacteria; In addition, because can also stoping the breathing of antibacterial, these high molecular Chinese herbal medicine extracts reach the effect of killing antibacterial.Such as Oleum menthae is wherein rich in flavonoid glycoside and multiple organic acid, staphylococcus aureus, escherichia coli, streptococcus and Salmonella are had to stronger inhibitory action; Flos Lonicerae extract has obvious inhibitory action to staphylococcus aureus, Bacillus typhi, Diplococcus pneumoniae, bacillus pyocyaneus and influenza virus; The andrographolide containing in Herba Andrographis extract and neoandrographolide have obvious inhibitory action to escherichia coli; Some composition in Cortex Phellodendri extract can anti-bacteria breathing and RNA synthetic, the various bacteria such as staphylococcus aureus, streptococcus pneumoniae, tubercule bacillus, bacillus pyocyaneus, dysentery bacterium are all had to extraordinary inhibitory action.Chlorhexidine is as the main bactericidal component in formula, its sterilization mechanism is that it has cation surface activating, be easy to be adsorbed on electronegative bacterial cell membrane, cause the damage of breaking of bacterial cell membrane, make low-molecular-weight Cytoplasm become to distribute; In addition, the dehydrogenase that Chlorhexidine can anti-bacteria inside and oxidase isoreactivity enzyme synthetic, makes it that dysbolismus occur, thereby causes antibacterial death; Chlorhexidine is kill vegetative forms of bacteria effectively, but tubercule bacillus, fungus and bacterial spore are only had to inhibitory action, also invalid to virus.The bactericidal component of its pivotal role of another in formula is triclosan, and it is a kind of high-effective broad-spectrum fungicide, acts on the cell membrane of antibacterial, destroys cell membrane, its content is leaked and reaches the object of quick sterilization; Triclosan all has efficient inhibitory or killing effect to common antibacterial, fungus and virus, but all has good killing property for multiple gram positive bacteria and gram negative bacteria, and effect is lasting rapidly.As can be seen here, these several antibacterial compound recipes are fitted in together, the defect that used time fungicidal spectrum is narrow, germicidal efficiency is low of doing that makes up one-component that can be real, and reach a kind of Synergistic biocidal, work in coordination with the effect of entering altogether, thereby meet the sterilization " powerful quick-acting " of the disposable compound recipe hand sanitizing fluid of this formula.
2.2 nertralizer authentication test results
It is Pseudomonas aeruginosa (ATCC 15442) that nertralizer qualification test is selected strain, use sterile distilled water 5ml, by the Pseudomonas aeruginosa (ATCC 15442) of cultivating through 24h, with being that the phosphate buffer (PSB) of the 0.03mol/L of 1% tryptone is diluted to bacteria suspension containing mass fraction, pH is 7.2～7.4.According to the test method of regulation in " disinfection technology standard " (version in 2002), set 6 groups of parallel tests, test by suspension quantitative method.Result is as following table:
| Group | Average bacterium number (cfu/ml) |
| Disinfectant+bacteria suspension → cultivation | 0 |
| (disinfectant+bacteria suspension)+nertralizer → cultivation | 56 |
| Nertralizer+bacteria suspension → cultivation | 25700000 |
| (disinfectant+nertralizer)+bacteria suspension → cultivation | 26100000 |
| Diluent+bacteria suspension → cultivation | 25900000 |
| Diluent+nertralizer+aseptic culture medium → cultivation | 0 |
In above-mentioned test, diluent is sterile distilled water.As seen from the above table, the 1st group long bacterium and the 2nd group be compared with more than the 1st group, but be few test organisms colony growth compared with the 3rd, 4,5 (groups); 3rd, 4,5 groups have analog quantity test organisms growth error rate to be no more than 15%, and between prescribed limit 1 × 107cfu/ml～5 × 107cfu/ml; The 6th group not long bacterium.Test that result is consistent in triplicate, illustrate that selected nertralizer and concentration are suitable.
2.3 Guantitative bactericidal test results
Its objective is at bacterial propagule and bacterial spore required dosage in experiment indoor measurement disinfectant is killed suspension or on carrier, to verify practical sterilization dose.The compound disinfectant that the disposable hand sanitizing fluid of this formula adopts Chlorhexidine, triclosan, Chinese herbal medicine extract complex and ethanol various sterilization composition system to join, Synergistic biocidal mutually, strong tens times and even hundreds of times of sterilizing ability during than single use, in addition fungicidal spectrum is also obviously widened, and has overcome the narrow defect of fungicidal spectrum of single component.Quantitative bacteric idal experiment result is specific as follows:
According to this formulated disinfectant solution, choose staphylococcus aureus (ATCC 6538), escherichia coli (8099), Candida albicans (ATCC 10231), Pseudomonas aeruginosa (ATCC 15442) and bacillus subtilis and prepare bacteria suspension as experimental strain and carry out quantitative bacteric idal experiment.This process is carried out according to the method step of " disinfection technology standard " (version in 2002), does not repeat them here.The disinfectant solution of preparing with the formula of embodiment tri-carries out quantitative disinfecting test, and experimental result is as following table:
Experimental data from above-mentioned table, in the time of effect 1min, this antibacterial disposable compound recipe hand sanitizing fluid to the average kill ratio of staphylococcus aureus, escherichia coli, Candida albicans and Pseudomonas aeruginosa all more than 99.95%, during to bacillus subtilis effect 2min, average kill ratio is all greater than 99.90%, kills the Dui Zhi of Shuoing≤5.00.And " disinfection technology standard " requires the sterile products for hands, skin and mucosa sterilization, staphylococcus aureus, escherichia coli and Candida albicans killed to the Dui Zhi of Shuoing≤5.00.
From experimental result, fast, bactericidal property is superior in disinfectant solution sterilization prepared by this formula.
3 conclusions
The present invention develops that a kind of technological operation is easy, and energy consumption is low, preparation formula and the production technology thereof of antibacterial disposable compound recipe hand sanitizing fluid with low cost.The factory formula (in every 100ml solution) of the method: Chlorhexidine: 0.45g～0.55g; Triclosan: 0.1 ± 0.05g; Ethanol: 55 ± 5g; Dipropylene glycol: 0.5g～2g; Alkyl polyglucoside (APG0810): 0.1g～2g; Disodiumedetate: 0.01g～1g; Polyvinylpyrrolidone (PVP-K30): 0.01g～1g; Citric acid: 0.1g～2g; Chinese herbal medicine extract complex (tannin: 0.01g～1g, Oleum Eucalypti: 0.01g～1g, Oleum menthae: 0.01g～1g, Oleum Camphora: 0.01g～1g, Herba Violae: 0.01g～1g, Flos Lonicerae extract: 0.01g～1g, Radix Glycyrrhizae extract: 0.01g～1g, Cortex Phellodendri extract: 0.01g～1g, Fructus cnidii extract: 0.01g～1g, Galla halepensis extract: 0.01g～1g, Balsamiferou Blumea Herb extract: 0.01g～1g, Herba Andrographis extract: 0.01g～1g) essence, pigment is appropriate; Water surplus.Its production technology: add successively Chlorhexidine, ethanol by proportioning raw materials, then shake up, fully mix; Then add successively triclosan, dipropylene glycol, alkyl polyglucoside, Chinese herbal medicine extract complex, after stirring, add disodiumedetate; Polyvinylpyrrolidone is dissolved in appropriate water, adds the about 30min of stirring and evenly mixing in above-mentioned solution; Then add essence, pigment, regulating its pH with citric acid solution (mass fraction 20%) is between 7～9, supplies the water of surplus, obtains product.This disposable hand sanitizing fluid sterilization fast, almost reaches the effect of complete sterilizing in effect 2min; Meanwhile, overcome on the market most of this series products penetrating odor large, the glutinous greasy defect of washing one's hands.In addition, disinfectant solution good stability, through depositing after three months effectively sterilization component degradation rate below 5% in 37 DEG C of calorstats.The extraction of the Chinese herbal medicine extract complex in formula is to utilize existing new technique---film extraction and separation technology, comprises shattering, separate, dewaxing, then filtration purification, concentrated the obtaining of process film extraction natural Chinese medicinal herb vegetable material.This production technology is easy and simple to handle, without heating, greatly reduces energy consumption, and applicable commercial production is promoted the use of.
Below in conjunction with embodiment, the present invention is further described.Enumerate embodiment below and be described more specifically the present invention, but the present invention is not subject to the restriction of these embodiment.
Embodiment 1
First get Chlorhexidine 4.5g and join stirring and dissolving in 500g ethanol, then add successively triclosan 1.5g, 10g dipropylene glycol, 20g alkyl polyglucoside (APG0810), Chinese herbal medicine extract complex (0.1g tannin, 0.1g Oleum Eucalypti, 0.1g Oleum menthae, 0.1g Oleum Camphora, 0.1g Herba Violae, 0.1g Flos Lonicerae extract, 0.1g Radix Glycyrrhizae extract, 0.1g Cortex Phellodendri extract, 0.1g Fructus cnidii extract, 0.1g Galla halepensis extract, 0.1g Balsamiferou Blumea Herb extract, 0.1g Herba Andrographis extract) stirring and dissolving adds 0.1g disodiumedetate after completely, 0.1g polyvinylpyrrolidone (PVP-K30) is dissolved in appropriate water, adds in above-mentioned solution and mix, fully dissolve 30min, then add essence, pigment appropriate, regulating its pH with citric acid is between 7～9, adds deionized water to 1000ml.Be mixed with the antibacterial disposable compound recipe hand sanitizing fluid of 1000ml.
Embodiment 2
First get Chlorhexidine 5.0g and join stirring and dissolving in 500g ethanol, then add successively 1.0g triclosan, 15g dipropylene glycol, 20g alkyl polyglucoside (APG0810), Chinese herbal medicine extract complex (0.5g tannin, 0.5g Oleum Eucalypti, 0.5g Oleum menthae, 0.5g Oleum Camphora, 0.5g Herba Violae, 0.5g Flos Lonicerae extract, 0.5g Radix Glycyrrhizae extract, 0.5g Cortex Phellodendri extract, 0.1g Fructus cnidii extract, 0.1g Galla halepensis extract, 0.1g Balsamiferou Blumea Herb extract, 0.1g Herba Andrographis extract) stirring and dissolving adds 0.1g disodiumedetate after completely, 0.1g polyvinylpyrrolidone (PVP-K30) is dissolved in appropriate water, adds in above-mentioned solution and mix, fully dissolve 30min, then add essence, pigment appropriate, regulating its pH with citric acid is between 7～9, adds deionized water to 1000ml.Be mixed with the antibacterial disposable compound recipe hand sanitizing fluid of 1000ml.
Embodiment 3
First get Chlorhexidine 5.5g and join stirring and dissolving in 550g ethanol; Then add successively 0.5g triclosan, 10g dipropylene glycol, 10g alkyl polyglucoside (APG0810), Chinese herbal medicine extract complex (1g tannin, 1g Oleum Eucalypti, 1g Oleum menthae, 1g Oleum Camphora, 1g Herba Violae, 1g Flos Lonicerae extract, 1g Radix Glycyrrhizae extract, 1g Cortex Phellodendri extract, 1g Fructus cnidii extract, 1g Galla halepensis extract, 1g Balsamiferou Blumea Herb extract, 1g Herba Andrographis extract) stirring and dissolving to add 3.5g disodiumedetate completely; 5g polyvinylpyrrolidone (PVP-K30) is dissolved in appropriate water, adds in above-mentioned solution and mix, fully dissolve 30min; Then add essence, pigment appropriate, regulating its pH with citric acid is between 7～9, adds deionized water to 1000ml.Be mixed with the antibacterial disposable compound recipe hand sanitizing fluid of 1000ml.
Embodiment 4
First get Chlorhexidine 4.5g and join stirring and dissolving in 600g ethanol; Then add successively 1.5g triclosan, 5g dipropylene glycol, 10g alkyl polyglucoside (APG0810), Chinese herbal medicine extract complex (2g tannin, 2g Oleum Eucalypti, 2g Oleum menthae, 2g Oleum Camphora, 2g Herba Violae, 2g Flos Lonicerae extract, 2g Radix Glycyrrhizae extract, 2g Cortex Phellodendri extract, 2g Fructus cnidii extract, 2g Galla halepensis extract, 2g Balsamiferou Blumea Herb extract, 2g Herba Andrographis extract) stirring and dissolving to add 3.5g disodiumedetate completely; 10g polyvinylpyrrolidone (PVP-K30) is dissolved in appropriate water, adds in above-mentioned solution and mix, fully dissolve 30min; Then add essence, pigment appropriate, regulating its pH with citric acid is between 7～9, adds deionized water to 1000ml.Be mixed with the antibacterial disposable compound recipe hand sanitizing fluid of 1000ml.
Embodiment 5
First get Chlorhexidine 5.0g and join stirring and dissolving in 600g ethanol; Then add successively 1.0g triclosan, 10g dipropylene glycol, 10g alkyl polyglucoside (APG0810), Chinese herbal medicine extract complex (4g tannin, 4g Oleum Eucalypti, 4g Oleum menthae, 4g Oleum Camphora, 4g Herba Violae, 4g Flos Lonicerae extract, 4g Radix Glycyrrhizae extract, 4g Cortex Phellodendri extract, 4g Fructus cnidii extract, 4g Galla halepensis extract, 4g Balsamiferou Blumea Herb extract, 4g Herba Andrographis extract) stirring and dissolving to add 6.5g disodiumedetate completely; 10g polyvinylpyrrolidone (PVP-K30) is dissolved in appropriate water, adds in above-mentioned solution and mix, fully dissolve 30min; Then add essence, pigment appropriate, regulating its pH with citric acid is between 7～9, adds deionized water to 1000ml.Be mixed with the antibacterial disposable compound recipe hand sanitizing fluid of 1000ml.
Embodiment 6
First get Chlorhexidine 4.5g and join stirring and dissolving in 600g ethanol; Then add successively 1.5g triclosan, 15g dipropylene glycol, 10g alkyl polyglucoside (APG0810), Chinese herbal medicine extract complex (6g tannin, 6g Oleum Eucalypti, 6g Oleum menthae, 6g Oleum Camphora, 6g Herba Violae, 6g Flos Lonicerae extract, 6g Radix Glycyrrhizae extract, 6g Cortex Phellodendri extract, 6g Fructus cnidii extract, 6g Galla halepensis extract, 6g Balsamiferou Blumea Herb extract, 6g Herba Andrographis extract) stirring and dissolving to add 6.5g disodiumedetate completely; 10g polyvinylpyrrolidone (PVP-K30) is dissolved in appropriate water, adds in above-mentioned solution and mix, fully dissolve 30min; Then add essence, pigment appropriate, regulating its pH with citric acid is between 7～9, adds deionized water to 1000ml.Be mixed with the antibacterial disposable compound recipe hand sanitizing fluid of 1000ml.
Embodiment 7
First get Chlorhexidine 5.0g and join stirring and dissolving in 550g ethanol; Then add successively 1g triclosan, 10g dipropylene glycol, 1g alkyl polyglucoside (APG0810), Chinese herbal medicine extract complex (8g tannin, 8g Oleum Eucalypti, 8g Oleum menthae, 8g Oleum Camphora, 8g Herba Violae, 8g Flos Lonicerae extract, 8g Radix Glycyrrhizae extract, 8g Cortex Phellodendri extract, 8g Fructus cnidii extract, 8g Galla halepensis extract, 8g Balsamiferou Blumea Herb extract, 8g Herba Andrographis extract) stirring and dissolving to add 10g disodiumedetate completely; 5.0g polyvinylpyrrolidone (PVP-K30) is dissolved in appropriate water, adds in above-mentioned solution and mix, fully dissolve 30min; Then add essence, pigment appropriate, regulating its pH with citric acid is between 7～9, adds deionized water to 1000ml.Be mixed with the antibacterial disposable compound recipe hand sanitizing fluid of 1000ml.
Embodiment 8
First get Chlorhexidine 5.5g and join stirring and dissolving in 500g ethanol; Then add successively 0.5g triclosan, 5.0g dipropylene glycol, 1g alkyl polyglucoside (APG0810), Chinese herbal medicine extract complex (10g tannin, 10g Oleum Eucalypti, 10g Oleum menthae, 10g Oleum Camphora, 10g Herba Violae, 10g Flos Lonicerae extract, 10g Radix Glycyrrhizae extract, 10g Cortex Phellodendri extract, 10g Fructus cnidii extract, 10g Galla halepensis extract, 10g Balsamiferou Blumea Herb extract, 10g Herba Andrographis extract) stirring and dissolving to add 10g disodiumedetate completely; 0.1g polyvinylpyrrolidone (PVP-K30) is dissolved in appropriate water, adds in above-mentioned solution and mix, fully dissolve 30min; Then add essence, pigment appropriate, regulating its pH with citric acid is between 7～9, adds deionized water to 1000ml.Be mixed with the antibacterial disposable compound recipe hand sanitizing fluid of 1000ml.
The usefulness of the embodiment of the present invention is: sterilize quick and durable, when effect 2min, antibacterial average kill ratio is all greater than to 99.90%, kill logarithm value >5.00; The sticky feel of nothing after washing one's hands, good, the not dry hands of moistening effect; And without obvious sharp aroma.
The disposable hand sanitizing fluid of the embodiment of the present invention is owing to having adopted a kind of novel good non-ionic surface active agent alkyl-glucoside and polyvinylpyrrolidone to have the effect of moisturizing concurrently as stabilizing agent simultaneously, the chemical skin protectant that simultaneously adopts again multiple Chinese herbal medicine degerming skin care ingredient (such as tannin, Flos Lonicerae extract, Oleum Eucalypti etc.) and avoided using a large amount of greasy is as glycerol etc., make hand-washing effect excellent, imperceptible any glutinous soapy feeling.In addition, the addition of this formula handwashing liquid ethanol is quality volume fraction 50%～60%, can meet rapid-curing cutback effect, and simultaneously ethanol content is compared more on the low sidely with similar, and therefore penetrating odor is lighter.And in formula, add multiple herbal component, can reach the effect of extraordinary preserving moisture and protecting skin, made to use rear skin can not seem dry and astringent, more moistened care both hands.
In this description, the present invention is described with reference to its specific embodiment.But, still can make various amendments and conversion obviously and not deviate from the spirit and scope of the present invention.Therefore, description is regarded in an illustrative, rather than a restrictive.
Claims (6)
1. a disposable compound recipe hand sanitizing fluid, is characterized in that, raw material comprises following component, and each constituent mass volume ratio is:
Chlorhexidine 0.45%～0.55%;
Triclosan 0.05%～0.15%;
Chinese herbal medicine extract complex 0.12%～12%;
Alcohols 50%～60%;
Non-ionic surface active agent 0.1%～3%;
Penetrating agent 0.5%～2%;
All the other are water.
2. disposable compound recipe hand sanitizing fluid according to claim 1, is characterized in that, described Chinese herbal medicine extract complex comprises following component, and each component mass volume ratio in described disposable compound recipe hand sanitizing fluid is:
Tannin: 0.01%～1%;
Oleum Eucalypti: 0.01%～1%;
Oleum menthae: 0.01%～1%;
Oleum Camphora: 0.01%～1%;
Herba Violae: 0.01%～1%;
Flos Lonicerae extract: 0.01%～1%;
Radix Glycyrrhizae extract: 0.01%～1%;
Cortex Phellodendri extract: 0.01%～1%;
Fructus cnidii extract: 0.01%～1%;
Galla halepensis extract: 0.01%～1%;
Balsamiferou Blumea Herb extract: 0.01%～1%;
Herba Andrographis extract: 0.01%～1%.
3. disposable compound recipe hand sanitizing fluid according to claim 1, is characterized in that, described alcohols comprises following component, and each component mass volume ratio in described disposable compound recipe hand sanitizing fluid is:
Ethanol: 50%～60%;
Dipropylene glycol: 0.5%～2%.
4. disposable compound recipe hand sanitizing fluid according to claim 1, is characterized in that, described ionic surfactant pack is drawn together following component, and each component mass volume ratio in described disposable compound recipe hand sanitizing fluid is:
Alkyl polyglucoside: 0.1%～2%;
Polyvinylpyrrolidone: 0.01%～1%.
5. disposable compound recipe hand sanitizing fluid according to claim 1, is characterized in that, described disposable compound recipe hand sanitizing fluid also comprises the component of following mass volume ratio:
Citric acid: 0.1%～2%;
Disodiumedetate: 0.01%～1%.
6. a preparation method for disposable compound recipe hand sanitizing fluid, is characterized in that, comprises the following steps:
Step 1: add successively the Chlorhexidine of 0.45%～0.55% mass volume ratio, the ethanol of 50%～60% mass volume ratio, then shake up, fully mix;
Step 2: the mixture of step 1 gained is added successively to the triclosan of 0.05%～0.15% mass volume ratio, the dipropylene glycol of 0.5%～2% mass volume ratio, the alkyl polyglucoside of 0.1%～2% mass volume ratio, the Chinese herbal medicine extract complex of 0.12%～12% mass volume ratio under constantly stirring, add the disodiumedetate of 0.01%～1% mass volume ratio after stirring;
Step 3: the polyvinylpyrrolidone of 0.01%～1% mass volume ratio is dissolved in the water, is added the about 30min of stirring and evenly mixing in the solution of step 2 gained;
Step 4: then the product of step 3 gained is added to essence, pigment, regulate between its pH to 7～9 with the citric acid solution of mass fraction 20%, supply the water of surplus.
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| CN104382807A (en) * | 2014-12-09 | 2015-03-04 | 南阳市汇博生物技术有限公司 | Alcohol-free washing-free antibacterial hand sanitizer and preparation method thereof |
| CN104490659A (en) * | 2014-12-02 | 2015-04-08 | 成都顺发消洗科技有限公司 | Hand sanitizer |
| CN104593169A (en) * | 2015-01-20 | 2015-05-06 | 中国日用化学工业研究院 | Disinfectant cleaning agent containing guanidine salt and preparation method of disinfectant cleaning agent |
| CN111150697A (en) * | 2020-03-02 | 2020-05-15 | 达威控股有限公司 | Wash-free antibacterial hand sanitizer and preparation method thereof |
| US10683121B2 (en) | 2015-08-18 | 2020-06-16 | Biosystems Technology Limited | Method for preparation of research organisms |
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| CN111789796A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Disinfectant with liposome-encapsulated bactericidal component and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490659A (en) * | 2014-12-02 | 2015-04-08 | 成都顺发消洗科技有限公司 | Hand sanitizer |
| CN104382807A (en) * | 2014-12-09 | 2015-03-04 | 南阳市汇博生物技术有限公司 | Alcohol-free washing-free antibacterial hand sanitizer and preparation method thereof |
| CN104593169A (en) * | 2015-01-20 | 2015-05-06 | 中国日用化学工业研究院 | Disinfectant cleaning agent containing guanidine salt and preparation method of disinfectant cleaning agent |
| CN104593169B (en) * | 2015-01-20 | 2017-12-08 | 中国日用化学工业研究院 | A kind of disinfection cleaning agent containing guanidinesalt and preparation method thereof |
| US10683121B2 (en) | 2015-08-18 | 2020-06-16 | Biosystems Technology Limited | Method for preparation of research organisms |
| CN111150697A (en) * | 2020-03-02 | 2020-05-15 | 达威控股有限公司 | Wash-free antibacterial hand sanitizer and preparation method thereof |
| CN111789796A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Disinfectant with liposome-encapsulated bactericidal component and preparation method thereof |
| CN113967185A (en) * | 2020-07-22 | 2022-01-25 | 山东菏泽三仪生物工程有限公司 | No-clean disinfectant and preparation method thereof |
| CN111714424A (en) * | 2020-08-07 | 2020-09-29 | 泰州市榕兴医疗用品股份有限公司 | Hand-washing-free disinfection gel |
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Application publication date: 20140813 |